Detailed information for compound 1455676

Basic information

Technical information
  • TDR Targets ID: 1455676
  • Name: 3,4-dihydro-2H-quinolin-1-yl-(4-propan-2-ylox yphenyl)methanone
  • MW: 295.376 | Formula: C19H21NO2
  • H donors: 0 H acceptors: 1 LogP: 4.1 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(Oc1ccc(cc1)C(=O)N1CCCc2c1cccc2)C
  • InChi: 1S/C19H21NO2/c1-14(2)22-17-11-9-16(10-12-17)19(21)20-13-5-7-15-6-3-4-8-18(15)20/h3-4,6,8-12,14H,5,7,13H2,1-2H3
  • InChiKey: PMGCIROJKPOQBT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3,4-dihydro-2H-quinolin-1-yl-(4-isopropoxyphenyl)methanone
  • SMR000106138
  • MLS000110207
  • AK-968/15360133
  • BIM-0046575.P001
  • ZINC00442689
  • IVK/9090140
  • Oprea1_083347
  • CBMicro_046423

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi heat shock protein 90, putative 0.0041 0.0043 0.4916
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0109 0.0141 0.014
Brugia malayi intermediate filament protein 0.0033 0.003 0.0029
Plasmodium falciparum histone acetyltransferase GCN5 0.0041 0.0043 0.1681
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0023 0.0022
Brugia malayi Cell death protein 3 precursor 0.0032 0.003 0.0029
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0045 0.0049 0.9145
Plasmodium falciparum sentrin-specific protease 1 0.0014 0.0002 0.0059
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0004
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0089 0.0112 0.0111
Loa Loa (eye worm) hypothetical protein 0.0207 0.0285 0.0284
Trichomonas vaginalis heat shock protein, putative 0.0035 0.0034 0.0356
Loa Loa (eye worm) intermediate filament protein 0.0033 0.003 0.0029
Plasmodium vivax multidomain scavenger receptor, putative 0.0021 0.0013 0.0482
Echinococcus granulosus intermediate filament protein 0.0033 0.003 0.003
Onchocerca volvulus Peroxidase homolog 0.0028 0.0023 0.1298
Schistosoma mansoni hypothetical protein 0.6849 1 1
Echinococcus multilocularis endoplasmin 0.0045 0.0049 0.0049
Onchocerca volvulus Peroxidasin homolog 0.0028 0.0023 0.1298
Treponema pallidum replicative DNA helicase (dnaB) 0.0406 0.0576 0.6348
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0038 0.0405
Echinococcus granulosus cpg binding protein 0.0032 0.0029 0.0029
Echinococcus granulosus RUN 0.0021 0.0013 0.0013
Trichomonas vaginalis endoplasmin, putative 0.0035 0.0034 0.0356
Onchocerca volvulus 0.0033 0.003 0.1727
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0021 0.082
Echinococcus granulosus geminin 0.0355 0.0503 0.0503
Brugia malayi follicle stimulating hormone receptor 0.028 0.0392 0.0391
Schistosoma mansoni microtubule-associated protein tau 0.0724 0.1042 0.1042
Brugia malayi Smad1 0.0017 0.0008 0.0007
Schistosoma mansoni Replicative DNA helicase 0.0406 0.0576 0.0576
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0022
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.03 0.0421 0.0799
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0022
Toxoplasma gondii Hsp90 domain-containing protein 0.0182 0.0249 1
Giardia lamblia Heat shock protein HSP 90-alpha 0.0041 0.0043 0.046
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0002 0.0001
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.007 0.0084 0.0935
Loa Loa (eye worm) hypothetical protein 0.0113 0.0147 0.0146
Trypanosoma brucei heat shock protein, putative 0.0048 0.0053 1
Echinococcus multilocularis protein dispatched 1 0.0101 0.0131 0.0131
Entamoeba histolytica hypothetical protein 0.0075 0.0093 0.1033
Loa Loa (eye worm) hypothetical protein 0.0015 0.0005 0.0004
Plasmodium falciparum heat shock protein 90, putative 0.0182 0.0249 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0007 0.0007
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0006 0.0006
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0008 0.0008
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.0023 0.0022
Onchocerca volvulus 0.0021 0.0013 0.0704
Brugia malayi CHE-14 protein 0.0089 0.0112 0.0111
Brugia malayi hypothetical protein 0.0026 0.0021 0.002
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0048 0.0521
Brugia malayi hypothetical protein 0.0021 0.0013 0.0012
Plasmodium vivax sentrin-specific protease 1, putative 0.0014 0.0002 0.0059
Brugia malayi Doublecortin family protein 0.0021 0.0013 0.0012
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.0392 0.0391
Schistosoma mansoni peroxidasin 0.0028 0.0023 0.0023
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.6849 1 1
Loa Loa (eye worm) hypothetical protein 0.0129 0.0171 0.017
Trypanosoma cruzi Heat shock protein 83, putative 0.0048 0.0053 0.6153
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0017 0.0007 0.088
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0014 0.0002 0.0059
Echinococcus granulosus endoplasmin 0.0045 0.0049 0.0049
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.003 0.0029
Echinococcus granulosus histone acetyltransferase KAT2B 0.0148 0.0199 0.0199
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0038 0.0037
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.003 0.0029
Trypanosoma cruzi heat shock protein 85, putative 0.0041 0.0043 0.4916
Leishmania major heat shock protein 83-1 0.0048 0.0053 1
Brugia malayi Peroxidasin 0.0028 0.0023 0.0022
Toxoplasma gondii heat shock protein HSP90 0.0048 0.0053 0.2095
Echinococcus multilocularis lamin 0.0033 0.003 0.003
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0038 0.0405
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0613 0.0879 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0007 0.088
Loa Loa (eye worm) heat shock protein 75 0.0032 0.0029 0.0028
Onchocerca volvulus 0.0038 0.0038 0.2177
Schistosoma mansoni patched 1 0.0089 0.0112 0.0112
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0017 0.0007 0.0542
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0007 0.088
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3265 0.4758 0.9174
Brugia malayi Blistered cuticle protein 3 0.0028 0.0023 0.0022
Schistosoma mansoni cpg binding protein 0.003 0.0027 0.0027
Brugia malayi beta-lactamase family protein 0.0038 0.0038 0.0037
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.03 0.0421 0.226
Schistosoma mansoni hypothetical protein 0.0085 0.0108 0.0108
Schistosoma mansoni hypothetical protein 0.0032 0.003 0.003
Treponema pallidum fructose-bisphosphate aldolase 0.0613 0.0879 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0007 0.0006
Loa Loa (eye worm) RNA binding protein 0.0066 0.008 0.0079
Loa Loa (eye worm) hypothetical protein 0.0026 0.0021 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0038 0.4329
Echinococcus granulosus sentrin specific protease 1 0.0014 0.0002 0.0002
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0241 0.0336 0.0635
Brugia malayi Niemann-Pick C1 protein precursor 0.0207 0.0285 0.0284
Trypanosoma cruzi heat shock protein 85, putative 0.0048 0.0053 0.6153
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.007 0.0084 0.0935
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0613 0.0879 1
Entamoeba histolytica hypothetical protein 0.0075 0.0093 0.1033
Onchocerca volvulus Peroxidase homolog 0.0028 0.0023 0.1298
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0022
Echinococcus granulosus lamin 0.0033 0.003 0.003
Trypanosoma brucei heat shock protein, putative 0.0048 0.0053 1
Brugia malayi CXXC zinc finger family protein 0.003 0.0027 0.0026
Echinococcus multilocularis expressed conserved protein 0.0194 0.0266 0.0266
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0017 0.0007 0.0238
Schistosoma mansoni hypothetical protein 0.0085 0.0108 0.0108
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0066 0.008 0.0079
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.007 0.0084 0.0084
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0093 0.0093
Trypanosoma brucei heat shock protein 90, putative 0.0048 0.0053 1
Echinococcus granulosus GPCR family 2 0.0017 0.0007 0.0007
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0014 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0001
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0038 0.0405
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0002 0.0001
Echinococcus granulosus heat shock protein 90 0.0048 0.0053 0.0053
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0038 0.006
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0022
Leishmania major heat shock protein 83-1 0.0048 0.0053 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0006 0.0005
Loa Loa (eye worm) hypothetical protein 0.0038 0.0038 0.0037
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0022
Mycobacterium tuberculosis Conserved protein 0.0038 0.0038 0.006
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0045 0.0049 0.0063
Loa Loa (eye worm) heat shock protein 90 0.0048 0.0053 0.0052
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0089 0.0112 0.0111
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0032 0.0029 0.0029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0613 0.0879 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0022
Onchocerca volvulus 0.0014 0.0002 0.0086
Toxoplasma gondii heat shock protein 90, putative 0.0048 0.0053 0.2095
Plasmodium vivax heat shock protein, putative 0.0182 0.0249 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0048 0.1901
Schistosoma mansoni Smad4 0.0017 0.0008 0.0008
Brugia malayi beta-lactamase family protein 0.0038 0.0038 0.0037
Leishmania major heat shock protein 83-1 0.0048 0.0053 1
Brugia malayi acetyltransferase, GNAT family protein 0.0152 0.0205 0.0204
Echinococcus granulosus muscleblind protein 0.0313 0.0441 0.0441
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0052 0.0059 0.0058
Loa Loa (eye worm) hypothetical protein 0.0129 0.0171 0.017
Trichomonas vaginalis esterase, putative 0.0038 0.0038 0.0405
Echinococcus granulosus Polycystic kidney disease protein 0.0021 0.0013 0.0013
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0124 0.0164 0.0164
Onchocerca volvulus 0.0021 0.0013 0.0704
Brugia malayi heat shock protein 90 0.0048 0.0053 0.0052
Leishmania major heat shock protein 83-1 0.0048 0.0053 1
Echinococcus granulosus Protein patched homolog 1 0.0089 0.0112 0.0112
Brugia malayi MH1 domain containing protein 0.0017 0.0008 0.0007
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0049 0.0526
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0007 0.0007
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.0112 0.1253
Echinococcus multilocularis transcription factor eb 0.0113 0.0148 0.0148
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0613 0.0879 1
Mycobacterium leprae Conserved hypothetical protein 0.1196 0.1732 1
Brugia malayi Muscleblind-like protein 0.0313 0.0441 0.044
Brugia malayi MH1 domain containing protein 0.0017 0.0008 0.0007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0613 0.0879 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0093 0.0093
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0021 0.23
Leishmania major hypothetical protein, conserved 0.0026 0.0021 0.3738
Echinococcus multilocularis RUN 0.0021 0.0013 0.0013
Brugia malayi RNA binding protein 0.0066 0.008 0.0079
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0007 0.0007
Schistosoma mansoni peroxidasin 0.0028 0.0023 0.0023
Echinococcus multilocularis sentrin specific protease 8 0.007 0.0084 0.0084
Echinococcus multilocularis heat shock protein 0.0048 0.0053 0.0053
Leishmania major heat shock protein 83-1 0.0048 0.0053 1
Echinococcus multilocularis muscleblind protein 0.0313 0.0441 0.0441
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0048 0.0521
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0038 0.7035
Echinococcus multilocularis apoptotic protease activating factor 1 0.0032 0.003 0.003
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0027 0.0026
Trypanosoma cruzi heat shock protein 85, putative 0.0048 0.0053 0.6153
Onchocerca volvulus 0.0033 0.003 0.1727
Echinococcus granulosus Niemann Pick C1 protein 0.0295 0.0414 0.0414
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0022
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0017 0.0007 0.0007
Mycobacterium ulcerans heat shock protein 90 0.0045 0.0049 0.0198
Plasmodium falciparum LCCL domain-containing protein 0.0021 0.0013 0.0482
Echinococcus multilocularis Niemann Pick C1 protein 0.0295 0.0414 0.0414
Schistosoma mansoni hypothetical protein 0.6849 1 1
Echinococcus granulosus heat shock protein 90 0.0041 0.0043 0.0043
Entamoeba histolytica heat shock protein 90, putative 0.0048 0.0053 0.0575
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0014 0.0002 0.0059
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0124 0.0164 0.0164
Echinococcus multilocularis tar DNA binding protein 0.0066 0.008 0.008
Brugia malayi isocitrate dehydrogenase 0.0017 0.0007 0.0006
Leishmania major heat shock protein 83-1 0.0048 0.0053 1
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0013 0.0013
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.007 0.0084 0.0935
Plasmodium vivax heat shock protein 86, putative 0.0048 0.0053 0.2095
Trypanosoma brucei heat shock protein 90, putative 0.0048 0.0053 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0038 0.006
Schistosoma mansoni hypothetical protein 0.0021 0.0013 0.0013
Onchocerca volvulus 0.0038 0.0038 0.2177
Loa Loa (eye worm) hypothetical protein 0.0038 0.0038 0.0037
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0021 0.082
Schistosoma mansoni tar DNA-binding protein 0.0066 0.008 0.008
Brugia malayi Hsp90 protein 0.0032 0.0029 0.0028
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0048 0.0048
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0038 0.1491
Brugia malayi hypothetical protein 0.0075 0.0093 0.0092
Schistosoma mansoni intermediate filament proteins 0.0033 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0085 0.0108 0.0108
Toxoplasma gondii ABC1 family protein 0.0038 0.0038 0.1491
Brugia malayi RNA recognition motif domain containing protein 0.0066 0.008 0.0079
Giardia lamblia Fructose-bisphosphate aldolase 0.0613 0.0879 1
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0014 0.0002 0.0002
Plasmodium falciparum endoplasmin, putative 0.0035 0.0034 0.1318
Echinococcus granulosus caspase 2 0.0032 0.003 0.003
Mycobacterium tuberculosis Conserved protein 0.0038 0.0038 0.006
Leishmania major heat shock protein 83-1 0.0048 0.0053 1
Echinococcus granulosus lamin dm0 0.0033 0.003 0.003
Entamoeba histolytica hypothetical protein 0.0075 0.0093 0.1033
Leishmania major heat shock protein 83-1 0.0048 0.0053 1
Brugia malayi MH2 domain containing protein 0.0017 0.0008 0.0007
Schistosoma mansoni tar DNA-binding protein 0.0066 0.008 0.008
Giardia lamblia Histone acetyltransferase GCN5 0.0041 0.0043 0.0459
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0023 0.0022
Echinococcus multilocularis sentrin specific protease 7 0.0014 0.0002 0.0002
Schistosoma mansoni tar DNA-binding protein 0.0066 0.008 0.008
Chlamydia trachomatis replicative DNA helicase 0.0406 0.0576 1
Onchocerca volvulus Cell death protein 3 homolog 0.0032 0.003 0.1711
Schistosoma mansoni cpg binding protein 0.0032 0.0029 0.0029
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1701 0.2471 0.2471
Echinococcus multilocularis muscleblind protein 1 0.0313 0.0441 0.0441
Wolbachia endosymbiont of Brugia malayi recombinase A 0.0113 0.0148 0.1891
Onchocerca volvulus 0.0028 0.0023 0.1298
Trichomonas vaginalis heat shock protein, putative 0.0041 0.0043 0.046
Schistosoma mansoni smad1 5 8 and 0.0017 0.0008 0.0008
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0038 0.0038
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0035 0.0034
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0014 0.0002 0.0059
Leishmania major heat shock protein 83-1 0.0048 0.0053 1
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.6849 1 1
Mycobacterium ulcerans recombinase A 0.0113 0.0148 0.2052
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.0023 0.0022
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0007 0.0238
Onchocerca volvulus 0.0028 0.0023 0.1298
Leishmania major heat shock protein 83-1 0.0048 0.0053 1
Echinococcus granulosus sentrin specific protease 8 0.007 0.0084 0.0084
Loa Loa (eye worm) hypothetical protein 0.0038 0.0038 0.0037
Brugia malayi hypothetical protein 0.0017 0.0008 0.0007
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0038 0.0038
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0021 0.23
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0008 0.0008
Schistosoma mansoni smad1 5 8 and 0.0017 0.0008 0.0008
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0406 0.0576 1
Schistosoma mansoni loxhd1 0.0021 0.0013 0.0013
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0038 0.006
Echinococcus multilocularis sentrin specific protease 1 0.0014 0.0002 0.0002
Loa Loa (eye worm) endoplasmin 0.0048 0.0053 0.0052
Trypanosoma brucei heat shock protein, putative 0.0048 0.0053 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0059 0.0058
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0613 0.0879 1
Leishmania major heat shock protein, putative 0.0032 0.0029 0.5328
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0022
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0048 0.1901
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0017 0.0007 0.0007
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0038 0.006
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0059 0.0058
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0207 0.0285 0.3219
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0008 0.0008
Echinococcus granulosus expressed conserved protein 0.0194 0.0266 0.0266
Echinococcus granulosus sterol regulatory element binding protein 0.0089 0.0112 0.0112
Echinococcus multilocularis heat shock protein 90 0.0048 0.0053 0.0053
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0007 0.0006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0012
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0032 0.0029 0.0307
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0013 0.0013
Loa Loa (eye worm) hypothetical protein 0.0021 0.0013 0.0012
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0022
Leishmania major heat shock protein 83-1 0.0048 0.0053 1
Brugia malayi Endoplasmin precursor 0.0048 0.0053 0.0052
Trypanosoma brucei heat shock protein, putative 0.0048 0.0053 1
Echinococcus multilocularis Polycystic kidney disease protein 0.0021 0.0013 0.0013
Schistosoma mansoni lamin 0.0033 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0007
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.0023 0.0022
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0406 0.0576 0.3176
Echinococcus multilocularis GPCR, family 2 0.0017 0.0007 0.0007
Leishmania major heat shock protein 83-1 0.0048 0.0053 1
Echinococcus multilocularis sterol regulatory element binding protein 0.0089 0.0112 0.0112
Toxoplasma gondii heat shock protein 75, putative 0.0032 0.0029 0.1143
Echinococcus granulosus smad 0.0017 0.0008 0.0008
Brugia malayi TAR-binding protein 0.0066 0.008 0.0079
Loa Loa (eye worm) Smad1 0.0017 0.0008 0.0007
Entamoeba histolytica heat shock protein 90, putative 0.0048 0.0053 0.0575
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0022
Schistosoma mansoni tar DNA-binding protein 0.0066 0.008 0.008
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0613 0.0879 1
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0113 0.0148 0.0147
Schistosoma mansoni lipoxygenase 0.0087 0.0109 0.0109
Onchocerca volvulus Huntingtin homolog 0.0129 0.0171 1
Echinococcus multilocularis geminin 0.0355 0.0503 0.0503
Trypanosoma cruzi hypothetical protein 0.007 0.0084 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0038 0.0405
Echinococcus granulosus apoptotic protease activating factor 1 0.0032 0.003 0.003
Schistosoma mansoni lipoxygenase 0.0124 0.0164 0.0164
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0023 0.0022
Brugia malayi hypothetical protein 0.0129 0.0171 0.017
Echinococcus granulosus sentrin specific protease 7 0.0014 0.0002 0.0002
Trypanosoma cruzi DNA repair protein, putative 0.0035 0.0034 0.3807
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.007 0.0084 0.0083
Schistosoma mansoni polycystin 1-related 0.0021 0.0013 0.0013
Trypanosoma cruzi DNA repair protein, putative 0.0035 0.0034 0.3807
Schistosoma mansoni hypothetical protein 0.0355 0.0503 0.0503
Echinococcus granulosus microtubule associated protein 2 0.0724 0.1042 0.1042
Brugia malayi MH2 domain containing protein 0.025 0.0349 0.0348
Onchocerca volvulus Peroxidasin homolog 0.0028 0.0023 0.1298
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.0113 0.0148 0.0652
Schistosoma mansoni heat shock protein 0.0048 0.0053 0.0053
Brugia malayi beta-lactamase 0.0038 0.0038 0.0037
Plasmodium falciparum heat shock protein 90 0.0048 0.0053 0.2095
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0006
Onchocerca volvulus 0.003 0.0027 0.1514
Loa Loa (eye worm) hypothetical protein 0.0038 0.0038 0.0037
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0006 0.0006
Loa Loa (eye worm) Ulp1 protease 0.007 0.0084 0.0083
Loa Loa (eye worm) MH2 domain-containing protein 0.025 0.0349 0.0348
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0032 0.0029 0.167
Trichomonas vaginalis Sentrin-specific protease, putative 0.007 0.0084 0.0935
Echinococcus multilocularis lipoxygenase domain containing protein 0.0021 0.0013 0.0013
Trypanosoma brucei heat shock protein 84, putative 0.0032 0.0029 0.5328
Echinococcus granulosus lipoxygenase domain containing protein 0.0021 0.0013 0.0013
Echinococcus granulosus peroxidasin 0.0028 0.0023 0.0023
Plasmodium vivax endoplasmin, putative 0.0048 0.0053 0.2095
Loa Loa (eye worm) hypothetical protein 0.0313 0.0441 0.044
Echinococcus granulosus transcription factor eb 0.0113 0.0148 0.0148
Chlamydia trachomatis recombinase RecA 0.0113 0.0148 0.2544
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0014 0.0002 0.0002
Onchocerca volvulus 0.0032 0.003 0.1711
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0038 0.006
Echinococcus multilocularis cpg binding protein 0.0032 0.0029 0.0029
Echinococcus multilocularis caspase 2 0.0032 0.003 0.003
Leishmania major hypothetical protein, conserved 0.0038 0.0038 0.7035
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0024 0.024
Onchocerca volvulus 0.0038 0.0038 0.2177
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0032 0.0029 0.0029
Schistosoma mansoni heat shock protein 0.0048 0.0053 0.0053
Trypanosoma cruzi heat shock protein 85, putative 0.0048 0.0053 0.6153
Leishmania major heat shock protein 83-1 0.0048 0.0053 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.003 0.0029
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0007
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0038 0.0038
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0038 0.0405
Leishmania major heat shock protein 83-1 0.0048 0.0053 1
Onchocerca volvulus Dual oxidase homolog 0.0028 0.0023 0.1298
Trypanosoma brucei heat shock protein, putative 0.0048 0.0053 1
Schistosoma mansoni hypothetical protein 0.0085 0.0108 0.0108
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0007 0.0007
Trypanosoma cruzi heat shock protein 90, putative 0.0048 0.0053 0.6153
Treponema pallidum recombinase A 0.0113 0.0148 0.1201
Leishmania major heat shock protein 83-1 0.0048 0.0053 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0017 0.0007 0.0006
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0007
Loa Loa (eye worm) hypothetical protein 0.0038 0.0038 0.0037
Echinococcus multilocularis peroxidasin 0.0028 0.0023 0.0023
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0001
Loa Loa (eye worm) doublecortin family protein 0.0021 0.0013 0.0012
Schistosoma mansoni hypothetical protein 0.0075 0.0093 0.0093
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0038 0.006
Schistosoma mansoni cpg binding protein 0.0032 0.0029 0.0029
Echinococcus granulosus Smad4 0.0017 0.0008 0.0008
Schistosoma mansoni caspase-7 (C14 family) 0.0032 0.003 0.003
Loa Loa (eye worm) TAR-binding protein 0.0066 0.008 0.0079
Loa Loa (eye worm) hypothetical protein 0.0038 0.0038 0.0037
Giardia lamblia Grp94/Hsp90 0.0045 0.0049 0.0526
Trypanosoma brucei heat shock protein, putative 0.0048 0.0053 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0613 0.0879 1
Loa Loa (eye worm) twinkle helicase 0.0116 0.0152 0.0151
Loa Loa (eye worm) acetyltransferase 0.0152 0.0205 0.0204
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0017 0.0007 0.0007
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0064 0.0076 0.0076
Trypanosoma brucei heat shock protein, putative 0.0048 0.0053 1
Trypanosoma cruzi heat shock protein 90, putative 0.002 0.0012 0.1174
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0008 0.0007
Onchocerca volvulus Huntingtin homolog 0.0129 0.0171 1
Echinococcus multilocularis dnaJ subfamily B 0.0429 0.061 0.061
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.0035 0.0034 0.6188
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0038 0.006
Echinococcus multilocularis musashi 0.0033 0.003 0.003
Echinococcus granulosus dnaJ subfamily B 0.0429 0.061 0.061
Loa Loa (eye worm) hypothetical protein 0.0033 0.003 0.0029
Echinococcus multilocularis Smad4 0.0017 0.0008 0.0008
Schistosoma mansoni rab6-interacting 0.0021 0.0013 0.0013
Plasmodium vivax sentrin-specific protease 2, putative 0.0014 0.0002 0.0059
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0008 0.0008
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.03 0.0421 0.7115
Plasmodium vivax heat shock protein 90, putative 0.0032 0.0029 0.1143
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0007 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0038 0.4329
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0059 0.0058
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0406 0.0576 1
Loa Loa (eye worm) transcription factor SMAD2 0.025 0.0349 0.0348
Schistosoma mansoni endoplasmin 0.0048 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.0036 0.0035 0.0035
Schistosoma mansoni niemann-pick C1 (NPC1) 0.021 0.0289 0.0289
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0021 0.082
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0017 0.0007 0.0007
Toxoplasma gondii isocitrate dehydrogenase 0.0017 0.0007 0.0238
Giardia lamblia Heat shock protein HSP 90-alpha 0.0048 0.0053 0.0575
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0113 0.0147 0.0146
Schistosoma mansoni endoplasmin 0.0048 0.0053 0.0053
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0021 0.082
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0049 0.0526
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0022
Loa Loa (eye worm) blistered cuticle protein 3 0.0028 0.0023 0.0022
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0152 0.0205 0.0205
Loa Loa (eye worm) Ulp1 protease 0.0014 0.0002 0.0001
Leishmania major heat shock protein 83-1 0.0048 0.0053 1
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0041 0.0043 0.0043
Loa Loa (eye worm) hypothetical protein 0.0036 0.0035 0.0034
Trypanosoma brucei heat shock protein, putative 0.0048 0.0053 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0038 0.006
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0038 0.0038
Entamoeba histolytica acetyltransferase, GNAT family 0.0041 0.0043 0.0459
Mycobacterium tuberculosis Probable replicative DNA helicase DnaB 0.3558 0.5186 1
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0021 0.3738
Loa Loa (eye worm) hypothetical protein 0.0032 0.0029 0.0028
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0023 0.0022
Schistosoma mansoni hypothetical protein 0.0017 0.0007 0.0007
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0008 0.0007
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.6849 1 1
Echinococcus multilocularis heat shock protein 90 0.0041 0.0043 0.0043
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0014 0.0002 0.0001
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0017 0.0007 0.0238
Echinococcus granulosus tar DNA binding protein 0.0066 0.008 0.008
Schistosoma mansoni smad1 5 8 and 0.0017 0.0008 0.0008
Schistosoma mansoni tar DNA-binding protein 0.0066 0.008 0.008
Plasmodium falciparum heat shock protein 90, putative 0.0028 0.0024 0.0908
Brugia malayi Animal haem peroxidase family protein 0.0028 0.0023 0.0022
Echinococcus multilocularis microtubule associated protein 2 0.0724 0.1042 0.1042
Echinococcus granulosus Niemann Pick C1 protein 0.0207 0.0285 0.0285
Echinococcus multilocularis smad 0.0017 0.0008 0.0008
Loa Loa (eye worm) animal heme peroxidase 0.0028 0.0023 0.0022
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0022
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.007 0.0084 0.0935
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0007 0.0007
Schistosoma mansoni lamin 0.0033 0.003 0.003
Trichomonas vaginalis heat shock protein, putative 0.0048 0.0053 0.0575
Schistosoma mansoni hypothetical protein 0.0355 0.0503 0.0503
Schistosoma mansoni smad 0.0017 0.0008 0.0008
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0017 0.0007 0.0542
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0152 0.0205 0.0205
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0008 0.0007
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0045 0.0049 0.0081
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0613 0.0879 1
Echinococcus multilocularis lamin dm0 0.0033 0.003 0.003
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0093 0.0093
Entamoeba histolytica hypothetical protein 0.0075 0.0093 0.1033
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0048 0.1901
Brugia malayi MH2 domain containing protein 0.0017 0.0008 0.0007
Schistosoma mansoni hypothetical protein 0.0429 0.061 0.061
Leishmania major heat shock protein 83-1 0.0048 0.0053 1
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0072 0.2846
Schistosoma mansoni rab6-interacting 0.0021 0.0013 0.0013
Loa Loa (eye worm) beta-lactamase 0.0038 0.0038 0.0037
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0022
Echinococcus multilocularis Niemann Pick C1 protein 0.0207 0.0285 0.0285
Echinococcus multilocularis protein patched 0.0089 0.0112 0.0112
Loa Loa (eye worm) hypothetical protein 0.0032 0.003 0.0029
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0613 0.0879 1
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0007 0.0006
Brugia malayi hypothetical protein 0.0028 0.0023 0.0022
Loa Loa (eye worm) hypothetical protein 0.0313 0.0441 0.044
Trypanosoma cruzi heat shock protein, putative 0.0032 0.0029 0.3278
Brugia malayi hypothetical protein 0.0032 0.003 0.0029
Trypanosoma brucei Heat shock protein 83, putative 0.0048 0.0053 1
Echinococcus granulosus heat shock protein 0.0048 0.0053 0.0053
Onchocerca volvulus Chorion peroxidase homolog 0.0028 0.0023 0.1298
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0038 0.0037
Loa Loa (eye worm) hypothetical protein 0.0028 0.0023 0.0022
Brugia malayi hypothetical protein 0.0021 0.0013 0.0012
Schistosoma mansoni heat shock protein 0.0032 0.0029 0.0029
Onchocerca volvulus 0.0028 0.0023 0.1298

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 13.1154 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 22.3872 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 23.1093 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (binding) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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