Detailed information for compound 1456747

Basic information

Technical information
  • TDR Targets ID: 1456747
  • Name: 2-(8-methoxy-4-methyl-1-oxo-[1,2,4]triazino[4 ,5-a]indol-2-yl)-N-(2-phenylethyl)acetamide
  • MW: 390.435 | Formula: C22H22N4O3
  • H donors: 1 H acceptors: 2 LogP: 2.99 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc2c(c1)cc1n2c(C)nn(c1=O)CC(=O)NCCc1ccccc1
  • InChi: 1S/C22H22N4O3/c1-15-24-25(14-21(27)23-11-10-16-6-4-3-5-7-16)22(28)20-13-17-12-18(29-2)8-9-19(17)26(15)20/h3-9,12-13H,10-11,14H2,1-2H3,(H,23,27)
  • InChiKey: LREQKJIWHVWNLV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(1-keto-8-methoxy-4-methyl-[1,2,4]triazino[4,5-a]indol-2-yl)-N-(2-phenylethyl)acetamide
  • 2-(8-methoxy-4-methyl-1-oxo-[1,2,4]triazino[4,5-a]indol-2-yl)-N-(2-phenylethyl)ethanamide
  • C786-3371
  • NCGC00112908-01

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0033 0.0014 0.003
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0036 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0134 0.0128 0.0473
Echinococcus multilocularis FTZ F1 alpha 0.0036 0.0018 0.0016
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0066 0.0051 0.0049
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0478 0.0512 0.189
Loa Loa (eye worm) phosphatidylinositol 3 0.003 0.0011 0.0043
Toxoplasma gondii ABC1 family protein 0.018 0.0179 0.0644
Brugia malayi jmjC domain containing protein 0.0124 0.0116 0.0419
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0246 0.0253 0.0927
Trichomonas vaginalis PIKK family atypical protein kinase 0.0061 0.0045 0.1707
Echinococcus granulosus AMP activated protein kinase gamma regulatory 0.0063 0.0048 0.0046
Brugia malayi PHD-finger family protein 0.0028 0.0009 0.0019
Echinococcus granulosus geminin 0.0183 0.0182 0.018
Mycobacterium ulcerans hypothetical protein 0.0063 0.0048 0.0164
Trypanosoma cruzi target of rapamycin kinase 3 0.0072 0.0058 0.0174
Trichomonas vaginalis bromodomain-containing protein, putative 0.0044 0.0027 0.0927
Loa Loa (eye worm) hypothetical protein 0.0085 0.0073 0.027
Loa Loa (eye worm) jmjC domain-containing protein 0.0124 0.0116 0.0431
Brugia malayi Steroid receptor seven-up type 2 0.0036 0.0018 0.0055
Brugia malayi cytoplasmic intermediate filament protein 0.0073 0.0059 0.0208
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0018 0.0055
Loa Loa (eye worm) hypothetical protein 0.0033 0.0014 0.0052
Brugia malayi chloride channel protein 7 0.0063 0.0048 0.0164
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.2429 0.2696 0.2694
Brugia malayi jmjC domain containing protein 0.0033 0.0014 0.0039
Brugia malayi Voltage gated chloride channel family protein 0.0063 0.0048 0.0164
Onchocerca volvulus 0.0199 0.0201 0.1725
Schistosoma mansoni chloride channel protein 0.0063 0.0048 0.0048
Echinococcus granulosus L aminoadipate semialdehyde 0.009 0.0078 0.0076
Brugia malayi ecdysteroid receptor 0.0036 0.0018 0.0055
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0036 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0053 0.2017
Echinococcus granulosus H:Cl exchange transporter 4 0.0063 0.0048 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0011 0.0284
Loa Loa (eye worm) hypothetical protein 0.0063 0.0049 0.018
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0015 0.0014
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.018 0.0179 0.0652
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0068
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0122 0.0114 0.0112
Treponema pallidum Mg2+ transport protein (mgtE) 0.0063 0.0048 0.0826
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0221 0.0225 0.0824
Plasmodium falciparum thioredoxin reductase 0.0034 0.0015 0.0036
Schistosoma mansoni peptidase Clp (S14 family) 0.0478 0.0512 0.0512
Chlamydia trachomatis CBS domain-containing protein 0.0063 0.0048 0.0826
Mycobacterium tuberculosis Conserved protein 0.0063 0.0048 0.0164
Echinococcus granulosus tumor protein p63 0.1364 0.1504 0.1502
Loa Loa (eye worm) hypothetical protein 0.0063 0.0049 0.018
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.009 0.0079 0.0271
Mycobacterium leprae conserved hypothetical protein 0.0025 0.0006 0.0009
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.018 0.0179 0.0664
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0032 0.1149
Loa Loa (eye worm) chloride channel 3 0.0063 0.0048 0.0177
Trypanosoma brucei Voltage-gated Chloride channel Like 1 0.0063 0.0048 0.0155
Brugia malayi Bromodomain containing protein 0.0076 0.0063 0.0222
Mycobacterium tuberculosis Conserved protein 0.0063 0.0048 0.0164
Schistosoma mansoni hypothetical protein 0.0144 0.0138 0.0138
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.002 0.0634
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0036 0.0091
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0037 0.1372
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0018 0.0016
Leishmania major chloride channel protein, putative 0.0063 0.0048 0.0164
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0221 0.0225 0.0824
Trichomonas vaginalis penicillin-binding protein, putative 0.018 0.0179 0.7311
Trypanosoma cruzi chloride channel protein, putative 0.0063 0.0048 0.0135
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.2429 0.2696 1
Brugia malayi beta-lactamase family protein 0.018 0.0179 0.0652
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0081 0.0068 0.0212
Echinococcus multilocularis musashi 0.0137 0.013 0.0128
Brugia malayi beta-NAC-like protein 0.0038 0.002 0.0061
Brugia malayi Pre-SET motif family protein 0.003 0.0011 0.0028
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0032 0.1152
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.009 0.0079 0.5573
Brugia malayi Pre-SET motif family protein 0.0208 0.0211 0.077
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0033 0.0014 0.0009
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0036 0.0018 0.0018
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0875 0.0957 0.0955
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0079 0.3104
Echinococcus granulosus histone acetyltransferase KAT2B 0.0044 0.0027 0.0025
Loa Loa (eye worm) hypothetical protein 0.0069 0.0054 0.0202
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0165 0.0162 0.308
Toxoplasma gondii LsmAD domain-containing protein 0.0052 0.0036 0.0112
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0144 0.0139 0.0139
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0036 0.0018 0.0068
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0371 0.0393 0.0391
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0031 0.0105
Onchocerca volvulus 0.0137 0.013 0.1111
Toxoplasma gondii target of rapamycin (TOR), putative 0.0067 0.0053 0.0175
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0053 0.2017
Trypanosoma brucei transcription factor BTF3, putative 0.0038 0.002 0.0052
Plasmodium falciparum JmjC domain-containing protein, putative 0.0033 0.0014 0.0031
Entamoeba histolytica hypothetical protein 0.0025 0.0006 0.0182
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.0211 0.0782
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0002 0.0002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0053 0.2017
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0036 0.0018 0.0018
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.2429 0.2696 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0036 0.0018 0.0016
Trichomonas vaginalis penicillin-binding protein, putative 0.018 0.0179 0.7311
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.009 0.0079 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0059 0.0043 0.1616
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.2429 0.2696 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0053 0.2017
Schistosoma mansoni hypothetical protein 0.0048 0.0031 0.0031
Brugia malayi hypothetical protein 0.0085 0.0073 0.0258
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0011 0.0011
Echinococcus multilocularis neuropeptide receptor A26 0.0481 0.0515 0.0513
Trypanosoma brucei hypothetical protein, conserved 0.018 0.0179 0.0644
Echinococcus granulosus intermediate filament protein 0.0137 0.013 0.0128
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0114 0.0105 0.0379
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.018 0.0179 0.0179
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.2429 0.2696 1
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.2366 0.2626 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0025 0.0006 0.0009
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0031 0.0029
Loa Loa (eye worm) hypothetical protein 0.0114 0.0105 0.0391
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.1108 0.1218 0.451
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0246 0.0253 0.0927
Onchocerca volvulus 0.02 0.0201 0.1728
Leishmania major hypothetical protein, conserved 0.0052 0.0036 0.0121
Treponema pallidum hemolysin (tlyC) 0.0063 0.0048 0.0826
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0014 0.0052
Echinococcus multilocularis GPCR, family 2 0.0048 0.0031 0.0029
Echinococcus granulosus ubiquitin specific protease 41 0.0081 0.0068 0.0066
Brugia malayi Probable ClpP-like protease 0.0478 0.0512 0.189
Brugia malayi hypothetical protein 0.0114 0.0105 0.0379
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0033 0.0014 0.003
Loa Loa (eye worm) hypothetical protein 0.018 0.0179 0.0664
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0478 0.0512 0.1933
Schistosoma mansoni lamin 0.0137 0.013 0.013
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0063 0.0048 0.0177
Loa Loa (eye worm) hypothetical protein 0.0046 0.003 0.011
Loa Loa (eye worm) ICD-1 protein 0.0038 0.002 0.0073
Echinococcus granulosus JmjC domain containing protein 4 0.0033 0.0014 0.0012
Giardia lamblia 5-AMP-activated protein kinase, gamma-1 subunit 0.0063 0.0048 0.511
Wolbachia endosymbiont of Brugia malayi Mg2+/Co2+ transporter 0.0063 0.0048 0.0155
Giardia lamblia GTOR 0.009 0.0079 1
Brugia malayi nuclear hormone receptor 0.0036 0.0018 0.0055
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0165 0.0162 0.0588
Schistosoma mansoni jumonji domain containing protein 0.0122 0.0114 0.0114
Mycobacterium tuberculosis Probable hydrolase 0.018 0.0179 0.0652
Leishmania major CBS domain protein, conserved 0.0063 0.0048 0.0164
Mycobacterium leprae Probable lipase LipE 0.018 0.0179 0.0652
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.1321 0.1456 0.5394
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0122 0.0114 0.0112
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.003 0.003
Leishmania major hypothetical protein, conserved 0.0063 0.0048 0.0164
Plasmodium falciparum thioredoxin reductase 0.0097 0.0086 0.0307
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.003 0.0011 0.0021
Onchocerca volvulus Putative GMP reductase 0.1045 0.1147 1
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0063 0.0048 0.0164
Loa Loa (eye worm) hypothetical protein 0.0114 0.0105 0.0391
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0017 0.0015
Schistosoma mansoni coup transcription factor 0.0036 0.0018 0.0018
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0063 0.0048 0.0048
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0199 0.0201 0.0733
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.003 0.0011 0.003
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0046 0.003 0.003
Schistosoma mansoni hypothetical protein 0.0048 0.0031 0.0031
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0031 0.0029
Schistosoma mansoni hypothetical protein 0.0183 0.0182 0.0182
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0478 0.0512 0.1882
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0051 0.0178
Toxoplasma gondii NADPH-glutathione reductase 0.0034 0.0015 0.0035
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0114 0.0105 0.0391
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.2429 0.2696 1
Loa Loa (eye worm) hypothetical protein 0.0137 0.013 0.0484
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0038 0.1397
Echinococcus granulosus thioredoxin glutathione reductase 0.0097 0.0086 0.0084
Plasmodium vivax hypothetical protein, conserved 0.018 0.0179 0.0661
Onchocerca volvulus 0.003 0.0011 0.0067
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0058 0.2236
Schistosoma mansoni RAR-like nuclear receptor 0.0036 0.0018 0.0018
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0014 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0036 0.0018 0.0055
Brugia malayi acetyltransferase, GNAT family protein 0.0144 0.0139 0.0503
Mycobacterium tuberculosis Probable dehydrogenase 0.0221 0.0225 0.0824
Trichomonas vaginalis set domain proteins, putative 0.0237 0.0243 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0081 0.0068 0.2668
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0058 0.2236
Onchocerca volvulus 0.0199 0.0201 0.1725
Brugia malayi beta-lactamase 0.018 0.0179 0.0652
Toxoplasma gondii NAC domain-containing protein 0.0038 0.002 0.0052
Trypanosoma brucei GMP reductase 0.2429 0.2696 1
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0036 0.0018 0.0016
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0084 0.0084
Mycobacterium leprae Probable cystathionine beta-synthase CBS (Serine sulfhydrase) (Beta-thionase) (Hemoprotein H-450) 0.0063 0.0048 0.0164
Brugia malayi Nuclear hormone receptor-like 1 0.0036 0.0018 0.0055
Brugia malayi nuclear receptor NHR-88 0.0036 0.0018 0.0055
Schistosoma mansoni thyroid hormone receptor 0.0408 0.0434 0.0434
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0015 0.0035
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0095 0.0084 0.03
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0036 0.0018 0.0068
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.2366 0.2626 1
Loa Loa (eye worm) glutathione reductase 0.0097 0.0086 0.0319
Loa Loa (eye worm) acetyltransferase 0.0144 0.0139 0.0515
Echinococcus multilocularis ecdysone induced protein 78C 0.0036 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.0033 0.0014 0.0052
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0036 0.0018 0.0055
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0034 0.0015 0.0044
Schistosoma mansoni thyroid hormone receptor 0.0408 0.0434 0.0434
Mycobacterium ulcerans beta-lactamase 0.018 0.0179 0.0652
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0018 0.0055
Loa Loa (eye worm) hypothetical protein 0.0052 0.0036 0.0133
Loa Loa (eye worm) IMP dehydrogenase 1 0.2429 0.2696 1
Mycobacterium tuberculosis Probable conserved transmembrane alanine and leucine rich protein 0.0063 0.0048 0.0164
Brugia malayi GMP reductase 0.1045 0.1147 0.425
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0081 0.0068 0.0066
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0114 0.0105 0.0379
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.002 0.0634
Onchocerca volvulus 0.0199 0.0201 0.1725
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0221 0.0225 0.0824
Brugia malayi hypothetical protein 0.0052 0.0036 0.0121
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0478 0.0512 0.1882
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.009 0.0078 0.0277
Brugia malayi hypothetical protein 0.0144 0.0138 0.0502
Brugia malayi LBP / BPI / CETP family, N-terminal domain containing protein 0.0199 0.0201 0.0733
Echinococcus multilocularis thyroid hormone receptor alpha 0.0408 0.0434 0.0432
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0036 0.0018 0.0055
Toxoplasma gondii hypothetical protein 0.0165 0.0162 0.058
Onchocerca volvulus 0.0114 0.0105 0.0893
Onchocerca volvulus Protein ultraspiracle homolog 0.0036 0.0018 0.013
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.2429 0.2696 0.2694
Schistosoma mansoni hypothetical protein 0.0371 0.0393 0.0393
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.018 0.0179 0.0652
Wolbachia endosymbiont of Brugia malayi Mg/Co/Ni transporter MgtE 0.0063 0.0048 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.0077 0.0064 0.2484
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0084 0.0082
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0025 0.0006 0.0009
Plasmodium vivax thioredoxin reductase, putative 0.0097 0.0086 0.0307
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0246 0.0253 0.0927
Echinococcus multilocularis JmjC domain containing protein 4 0.0033 0.0014 0.0012
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.0051 0.0178
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0034 0.0015 0.0044
Onchocerca volvulus 0.0237 0.0243 0.2094
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0012
Brugia malayi CBS domain containing protein 0.0063 0.0048 0.0164
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0031 0.0029
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0036 0.0018 0.0016
Onchocerca volvulus 0.018 0.0179 0.1534
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0018 0.0016
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0478 0.0512 0.1933
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0114 0.0105 0.0391
Mycobacterium tuberculosis Probable reductase 0.0221 0.0225 0.0824
Toxoplasma gondii IMP dehydrogenas 0.2429 0.2696 1
Schistosoma mansoni cellular tumor antigen P53 0.02 0.0201 0.0201
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0014 0.0052
Leishmania major chloride channel protein, putative 0.0063 0.0048 0.0164
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0221 0.0225 0.0824
Loa Loa (eye worm) steroid hormone receptor 0.0036 0.0018 0.0068
Schistosoma mansoni steroid hormone receptor ad4bp 0.0036 0.0018 0.0018
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0478 0.0512 1
Trypanosoma brucei PAB1-binding protein , putative 0.0052 0.0036 0.0112
Echinococcus multilocularis lysine specific demethylase 5A 0.0122 0.0114 0.0112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0053 0.2017
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0044 0.0027 0.0927
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.0046 0.0044
Trypanosoma cruzi trypanothione reductase, putative 0.0034 0.0015 0.0014
Trichomonas vaginalis D-aminoacylase, putative 0.018 0.0179 0.7311
Brugia malayi intermediate filament protein 0.0137 0.013 0.0472
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0031 0.0117
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0036 0.0018 0.0016
Onchocerca volvulus 0.0085 0.0073 0.0607
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.0148 0.0537
Schistosoma mansoni chloride channel protein 0.0063 0.0048 0.0048
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.002 0.0031
Trichomonas vaginalis D-aminoacylase, putative 0.018 0.0179 0.7311
Mycobacterium tuberculosis Probable lipase LipD 0.018 0.0179 0.0652
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0017 0.0015
Echinococcus granulosus H:Cl exchange transporter 7 0.0063 0.0048 0.0046
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0081 0.0068 0.0241
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0044 0.0027 0.0078
Brugia malayi Intermediate filament tail domain containing protein 0.0137 0.013 0.0472
Leishmania major phosphatidylinositol 3-related kinase, putative 0.003 0.0011 0.003
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0033 0.0014 0.003
Trypanosoma brucei Voltage-gated Chloride channel Like 3 0.0063 0.0048 0.0155
Plasmodium vivax JmjC domain containing protein 0.0033 0.0014 0.0031
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.0234 0.0232
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0034 0.0015 0.0013
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.0015 0.0035
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0221 0.0225 0.0824
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0313 0.0328 0.1206
Echinococcus granulosus histone lysine methyltransferase setb 0.0046 0.003 0.0027
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0478 0.0512 0.1882
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0034 0.0015 0.0036
Echinococcus multilocularis zinc finger protein 0.0023 0.0003 0.0001
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0036 0.0018 0.0055
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0036 0.0018 0.0016
Schistosoma mansoni lamin 0.0137 0.013 0.013
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0081 0.0068 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0036 0.0018 0.0068
Toxoplasma gondii CBS family protein 0.0063 0.0048 0.0155
Schistosoma mansoni jumonji/arid domain-containing protein 0.0124 0.0116 0.0116
Echinococcus granulosus neuropeptide receptor A26 0.0481 0.0515 0.0513
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.018 0.0179 0.0652
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0046 0.003 0.0027
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0034 0.0015 0.0035
Trypanosoma cruzi transcription factor btf3, putative 0.0038 0.002 0.0031
Toxoplasma gondii chloride transporter, chloride channel (ClC) family protein 0.0063 0.0048 0.0155
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0144 0.0138 0.0136
Brugia malayi loechrig isoform VII 0.0063 0.0048 0.0164
Loa Loa (eye worm) hypothetical protein 0.0085 0.0073 0.027
Loa Loa (eye worm) hypothetical protein 0.0114 0.0105 0.0391
Schistosoma mansoni zinc finger protein 0.0023 0.0003 0.0003
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.0234 0.0232
Loa Loa (eye worm) LBP/BPI/CETP family domain-containing protein 0.0199 0.0201 0.0745
Schistosoma mansoni jumonji/arid domain-containing protein 0.0124 0.0116 0.0116
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0036 0.0018 0.0068
Echinococcus granulosus neuropeptide s receptor 0.0481 0.0515 0.0513
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0478 0.0512 0.189
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0034 0.0015 0.0036
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0011 0.0009
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0036 0.0018 0.0055
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.009 0.0079 0.0077
Schistosoma mansoni hypothetical protein 0.0047 0.003 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0058 0.2236
Schistosoma mansoni intermediate filament proteins 0.0137 0.013 0.013
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.1108 0.1218 0.451
Echinococcus multilocularis ubiquitin specific protease 41 0.0081 0.0068 0.0066
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0015 0.0014
Mycobacterium tuberculosis Probable lipase LipE 0.018 0.0179 0.0652
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0038 0.1397
Loa Loa (eye worm) hypothetical protein 0.0114 0.0105 0.0391
Loa Loa (eye worm) hypothetical protein 0.0063 0.0048 0.0177
Brugia malayi CLC chloride channel protein 0.0063 0.0048 0.0164
Onchocerca volvulus 0.0199 0.0201 0.1725
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0084 0.0082
Brugia malayi hypothetical protein 0.0229 0.0234 0.0855
Toxoplasma gondii thioredoxin reductase 0.0097 0.0086 0.0299
Echinococcus multilocularis L aminoadipate semialdehyde 0.009 0.0078 0.0076
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0072 0.0058 0.0194
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0025 0.0006 0.0009
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.009 0.0079 0.028
Mycobacterium ulcerans cystathionine beta-synthase 0.0063 0.0048 0.0164
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.009 0.0079 0.0079
Schistosoma mansoni hypothetical protein 0.0048 0.0031 0.0031
Mycobacterium tuberculosis Hypoxic response protein 1 Hrp1 0.0063 0.0048 0.0164
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0011 0.0284
Brugia malayi jmjC domain containing protein 0.0122 0.0114 0.0411
Schistosoma mansoni nuclear hormone receptor 0.0036 0.0018 0.0018
Onchocerca volvulus 0.018 0.0179 0.1534
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0033 0.0014 0.0009
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0044 0.0027 0.008
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.009 0.0078 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0081 0.0068 0.2668
Mycobacterium tuberculosis Conserved protein 0.0063 0.0048 0.0164
Trichomonas vaginalis conserved hypothetical protein 0.0085 0.0073 0.2859
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.003 0.0011 0.0009
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0478 0.0512 1
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0063 0.0048 0.511
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0058 0.0042 0.0156
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0034 0.0015 0.0013
Brugia malayi steroid hormone receptor 0.0036 0.0018 0.0055
Echinococcus multilocularis H(+):Cl() exchange transporter 4 0.0063 0.0048 0.0046
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0036 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.0033 0.0014 0.0052
Trichomonas vaginalis D-aminoacylase, putative 0.018 0.0179 0.7311
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0036 0.0115
Schistosoma mansoni bromodomain containing protein 0.0065 0.005 0.005
Schistosoma mansoni protein phosphatase 2C 0.0033 0.0014 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0032 0.1149
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.1045 0.1147 0.425
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0034 0.0015 0.0044
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0036 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0068
Mycobacterium tuberculosis Probable conserved lipoprotein 0.018 0.0179 0.0652
Wolbachia endosymbiont of Brugia malayi hemolysin 0.0063 0.0048 0.0155
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0036 0.0018 0.0016
Echinococcus granulosus 5' AMP activated protein kinase subunit gamma 0.0063 0.0048 0.0046
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0034 0.0015 0.0044
Echinococcus granulosus zinc finger protein 0.0023 0.0003 0.0001
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0313 0.0328 0.1206
Echinococcus granulosus ecdysone induced protein 78C 0.0036 0.0018 0.0016
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0015 0.0014
Loa Loa (eye worm) hypothetical protein 0.0063 0.0048 0.0177
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0063 0.0048 0.0048
Loa Loa (eye worm) loechrig isoform VII 0.0063 0.0048 0.0177
Trypanosoma cruzi chloride channel protein, putative 0.0063 0.0048 0.0135
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0478 0.0512 0.051
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0034 0.0016 0.0014
Echinococcus granulosus lysine specific demethylase 6a 0.0033 0.0014 0.0012
Brugia malayi beta-lactamase family protein 0.018 0.0179 0.0652
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.2429 0.2696 1
Loa Loa (eye worm) hypothetical protein 0.02 0.0201 0.0746
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0032 0.1152
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.018 0.0179 0.0652
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0079 0.3104
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0095 0.0084 0.0312
Brugia malayi hypothetical protein 0.0114 0.0105 0.0379
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0066 0.0051 0.0051
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.2366 0.2626 0.974
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0063 0.0048 0.0135
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0053 0.2017
Loa Loa (eye worm) hypothetical protein 0.0045 0.0028 0.0103
Schistosoma mansoni survival motor neuron protein 0.0047 0.003 0.003
Onchocerca volvulus 0.0047 0.003 0.0231
Loa Loa (eye worm) beta-lactamase 0.018 0.0179 0.0664
Plasmodium falciparum glutathione reductase 0.0097 0.0086 0.0307
Mycobacterium tuberculosis Conserved protein 0.018 0.0179 0.0652
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.0148 0.0549
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0068
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.018 0.0179 0.0179
Entamoeba histolytica hypothetical protein 0.0144 0.0138 1
Loa Loa (eye worm) hypothetical protein 0.0066 0.0051 0.019
Plasmodium falciparum ataxin-2 like protein, putative 0.0052 0.0036 0.0115
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.009 0.0079 0.025
Echinococcus granulosus lysine specific demethylase 5A 0.0124 0.0116 0.0114
Mycobacterium ulcerans hypothetical protein 0.0063 0.0048 0.0164
Echinococcus granulosus H:Cl exchange transporter 3 0.0063 0.0048 0.0046
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.002 0.0811
Onchocerca volvulus 0.0137 0.013 0.1111
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0018 0.0055
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0081 0.0068 0.0232
Echinococcus granulosus GPCR family 2 0.0048 0.0031 0.0029
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0038 0.002 0.0051
Leishmania major basic transcription factor 3a, putative 0.0038 0.002 0.0061
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0025 0.0005 0.0007
Loa Loa (eye worm) hypothetical protein 0.018 0.0179 0.0664
Mycobacterium leprae conserved hypothetical protein 0.0063 0.0048 0.0164
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.0148 0.0537
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0034 0.0015 0.0035
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0034 0.0015 0.0035
Echinococcus granulosus lamin dm0 0.0137 0.013 0.0128
Plasmodium falciparum basic transcription factor 3b, putative 0.0038 0.002 0.0053
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0066 0.0051 0.0178
Brugia malayi LBP/BPI 0.0085 0.0073 0.0258
Onchocerca volvulus 0.0199 0.0201 0.1725
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0036 0.0018 0.0016
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0478 0.0512 0.189
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0036 0.0018 0.0068
Echinococcus multilocularis transcription factor btf3 0.0038 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.018 0.0179 0.0664
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0011 0.0284
Trypanosoma cruzi hypothetical protein, conserved 0.018 0.0179 0.0624
Trichomonas vaginalis PIKK family atypical protein kinase 0.0054 0.0038 0.1397
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0032 0.1152
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.2429 0.2696 1
Trypanosoma brucei AMP-activated protein kinase, gamma regulatory subunit 0.0063 0.0048 0.0155
Schistosoma mansoni hypothetical protein 0.0183 0.0182 0.0182
Leishmania major phosphatidylinositol 3-kinase, putative 0.003 0.0011 0.003
Loa Loa (eye worm) hypothetical protein 0.0199 0.0201 0.0745
Echinococcus multilocularis tumor protein p63 0.1364 0.1504 0.1502
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0478 0.0512 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0034 0.0015 0.0035
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0073 0.0059 0.0221
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0033 0.0014 0.0014
Schistosoma mansoni protein kinase subunit gamma 0.0063 0.0048 0.0048
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0031 0.0029
Plasmodium vivax SET domain protein, putative 0.003 0.0011 0.002
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0068
Schistosoma mansoni jumonji domain containing protein 0.0033 0.0014 0.0014
Brugia malayi glutathione reductase 0.0097 0.0086 0.0307
Schistosoma mansoni phd/f-box containing protein 0.0033 0.0014 0.0014
Echinococcus multilocularis lamin dm0 0.0137 0.013 0.0128
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0081 0.0068 0.0066
Mycobacterium ulcerans esterase/lipase LipP 0.018 0.0179 0.0652
Loa Loa (eye worm) hypothetical protein 0.0043 0.0026 0.0096
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0068
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0066 0.0051 0.0178
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.009 0.0079 0.028
Treponema pallidum NADH oxidase 0.0034 0.0015 0.0185
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0036 0.0018 0.0055
Trypanosoma cruzi chloride channel protein, putative 0.0063 0.0048 0.0135
Leishmania major phosphopantetheinyl transferase-like protein 0.0025 0.0006 0.0009
Trypanosoma brucei trypanothione reductase 0.0097 0.0086 0.0299
Entamoeba histolytica hypothetical protein 0.0144 0.0138 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0067 0.0053 0.2017
Schistosoma mansoni retinoic acid receptor RXR 0.0036 0.0018 0.0018
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.2429 0.2696 0.2696
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0011 0.0284
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0015 0.0014
Brugia malayi jmjC domain containing protein 0.0033 0.0014 0.0039
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0137 0.013 0.0484
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0015 0.0044
Echinococcus granulosus lamin 0.0137 0.013 0.0128
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0036 0.0018 0.0016
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0165 0.0162 0.0595
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0015 0.0014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0036 0.0018 0.0068
Onchocerca volvulus 0.0199 0.0201 0.1725
Loa Loa (eye worm) hypothetical protein 0.0063 0.0048 0.0177
Brugia malayi jmjC domain containing protein 0.0033 0.0014 0.0039
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0031 0.0105
Giardia lamblia Manganese-dependent inorganic pyrophosphatase, putative 0.0063 0.0048 0.511
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0043 0.0025 0.0073
Plasmodium vivax ataxin-2 like protein, putative 0.0052 0.0036 0.0115
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.002 0.1256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0058 0.2236
Loa Loa (eye worm) hypothetical protein 0.0048 0.0031 0.0117
Echinococcus granulosus transcription factor btf3 0.0038 0.002 0.0018
Entamoeba histolytica transcription factor BTF3, putative 0.0038 0.002 0.1217
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0004 0.0002
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0034 0.0015 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0072 0.0058 0.2236
Plasmodium falciparum glutathione reductase 0.0034 0.0015 0.0036
Loa Loa (eye worm) chloride channel protein 7 0.0063 0.0048 0.0177
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0081 0.0068 0.0068
Trypanosoma cruzi Domain of unknown function DUF21, putative 0.0063 0.0048 0.0135
Trichomonas vaginalis mercuric reductase, putative 0.0034 0.0015 0.044
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0034 0.0015 0.0044
Onchocerca volvulus 0.0063 0.0048 0.0387
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0034 0.0015 0.0014
Echinococcus multilocularis H(+):Cl() exchange transporter 3 0.0063 0.0048 0.0046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0084 0.0084
Echinococcus granulosus jumonji domain containing 1A 0.0033 0.0014 0.0012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0032 0.1152
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0036 0.0018 0.0055
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0066 0.0051 0.0049
Mycobacterium tuberculosis Possible penicillin-binding protein 0.1149 0.1264 0.4682
Brugia malayi jmjC domain containing protein 0.0033 0.0014 0.0039
Mycobacterium ulcerans lipase LipD 0.018 0.0179 0.0652
Echinococcus granulosus SNF4:AMP activated protein kinase gamma subunit 0.0063 0.0048 0.0046
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0036 0.0018 0.0055
Brugia malayi ancient conserved domain protein 4 0.0063 0.0048 0.0164
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0081 0.0068 0.0212
Leishmania major guanosine monophosphate reductase 0.2429 0.2696 1
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0051 0.0049
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0034 0.0015 0.0015
Echinococcus multilocularis jumonji domain containing 1A 0.0033 0.0014 0.0012
Loa Loa (eye worm) hypothetical protein 0.0229 0.0234 0.0867
Plasmodium falciparum protein MAM3, putative 0.0063 0.0048 0.016
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0034 0.0015 0.0185
Schistosoma mansoni phosphatidylserine receptor 0.0033 0.0014 0.0014
Loa Loa (eye worm) hypothetical protein 0.0037 0.0019 0.0072
Trypanosoma cruzi trypanothione reductase, putative 0.0097 0.0086 0.0278
Onchocerca volvulus 0.009 0.0078 0.0652
Chlamydia trachomatis GutQ/KpsF family sugar-phosphate isomerase 0.0063 0.0048 0.0826
Echinococcus multilocularis peptidase Clp (S14 family) 0.0313 0.0328 0.0326
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0478 0.0512 0.19
Mycobacterium ulcerans transcriptional regulator 0.0063 0.0048 0.0164
Schistosoma mansoni hypothetical protein 0.0048 0.0031 0.0031
Schistosoma mansoni chloride channel protein 0.0063 0.0048 0.0048
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0095 0.0084 0.0082
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0165 0.0162 0.0595
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0034 0.0015 0.0035
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.0051 0.0049
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0072 0.0058 0.0203
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0034 0.0015 0.0036
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.003 0.0011 0.0011
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0036 0.0018 0.0018
Mycobacterium tuberculosis Conserved hypothetical membrane protein 0.0063 0.0048 0.0164
Leishmania major inosine-5-monophosphate dehydrogenase 0.2429 0.2696 1
Plasmodium vivax glutathione reductase, putative 0.0097 0.0086 0.0307
Echinococcus granulosus histone acetyltransferase KAT2B 0.0138 0.0132 0.013
Echinococcus multilocularis lamin 0.0137 0.013 0.0128
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.0051 0.0178
Schistosoma mansoni transcription factor LCR-F1 0.0144 0.0138 0.0138
Echinococcus multilocularis H(+):Cl() exchange transporter 7 0.0063 0.0048 0.0046
Leishmania major hypothetical protein, conserved 0.0033 0.0014 0.0039
Loa Loa (eye worm) thioredoxin reductase 0.0097 0.0086 0.0319
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0371 0.0393 0.0391
Mycobacterium ulcerans hypothetical protein 0.0063 0.0048 0.0164
Echinococcus granulosus beta LACTamase domain containing family member 0.018 0.0179 0.0177
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0011 0.0011
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0034 0.0015 0.0014
Echinococcus multilocularis lysine specific demethylase 6a 0.0033 0.0014 0.0012
Echinococcus multilocularis 5' AMP activated protein kinase subunit gamma 0.0063 0.0048 0.0046
Trichomonas vaginalis esterase, putative 0.018 0.0179 0.7311
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0081 0.0068 0.4804
Echinococcus multilocularis thioredoxin glutathione reductase 0.0097 0.0086 0.0084
Trypanosoma cruzi GMP reductase 0.2429 0.2696 1
Loa Loa (eye worm) hypothetical protein 0.018 0.0179 0.0664
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0036 0.0018 0.013
Loa Loa (eye worm) hypothetical protein 0.0085 0.0073 0.027
Loa Loa (eye worm) GMP reductase 0.1045 0.1147 0.4257
Brugia malayi Bromodomain containing protein 0.0041 0.0023 0.0073
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0036 0.0018 0.0068
Leishmania major trypanothione reductase 0.0097 0.0086 0.0307
Schistosoma mansoni AMP-activated protein kinase gamma regulatory subunit 0.0063 0.0048 0.0048
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0081 0.0068 0.0066
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.009 0.0079 0.5573
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0004 0.0002
Entamoeba histolytica hypothetical protein 0.0038 0.002 0.1217
Loa Loa (eye worm) hypothetical protein 0.018 0.0179 0.0664
Schistosoma mansoni transcription factor btf3 0.0038 0.002 0.002
Mycobacterium ulcerans hypothetical protein 0.018 0.0179 0.0652
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0036 0.0018 0.0018
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0097 0.0086 0.0307
Trypanosoma cruzi chloride channel protein, putative 0.0063 0.0048 0.0135
Mycobacterium leprae conserved hypothetical protein 0.018 0.0179 0.0652
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0144 0.0139 0.0137
Chlamydia trachomatis Mg++ transporter 0.0063 0.0048 0.0826
Onchocerca volvulus Bile acid receptor homolog 0.0036 0.0018 0.013
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0081 0.0068 0.2668
Trypanosoma cruzi PAB1-binding protein , putative 0.0052 0.0036 0.0091
Onchocerca volvulus 0.0114 0.0105 0.0893
Echinococcus multilocularis beta LACTamase domain containing family member 0.018 0.0179 0.0177
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0081 0.0068 0.0241
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0144 0.0138 0.0136
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.009 0.0079 0.028
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.2429 0.2696 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0068
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0081 0.0068 0.8364
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.003 0.0098
Entamoeba histolytica hypothetical protein 0.0144 0.0138 1
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0094 0.0337
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.002 0.0634
Toxoplasma gondii CBS domain-containing protein 0.0063 0.0048 0.0155
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.1321 0.1456 0.5394
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.003 0.0011 0.0009
Brugia malayi photoreceptor-specific nuclear receptor 0.0036 0.0018 0.0055
Mycobacterium tuberculosis Probable esterase LipL 0.018 0.0179 0.0652
Brugia malayi hypothetical protein 0.0034 0.0015 0.0044
Trypanosoma cruzi GMP reductase 0.2429 0.2696 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0012
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.003 0.0011 0.0021
Onchocerca volvulus 0.018 0.0179 0.1534
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0034 0.0016 0.0014
Mycobacterium tuberculosis Conserved protein 0.018 0.0179 0.0652
Loa Loa (eye worm) phosphatidylinositol 3 0.009 0.0079 0.0292
Toxoplasma gondii CBS domain-containing protein 0.0063 0.0048 0.0155
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0095 0.0084 0.0084
Trypanosoma cruzi hypothetical protein, conserved 0.018 0.0179 0.0624
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0011 0.0284
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0063 0.0048 0.0164
Plasmodium vivax basic transcription factor 3b, putative 0.0038 0.002 0.0053
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.001 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0037 0.1372
Entamoeba histolytica hypothetical protein 0.0144 0.0138 1
Schistosoma mansoni hypothetical protein 0.0023 0.0004 0.0004
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0036 0.0018 0.0055
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0095 0.0084 0.0082
Echinococcus multilocularis phd:f box containing protein 0.0033 0.0014 0.0012
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0068
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0034 0.0015 0.0036
Loa Loa (eye worm) hypothetical protein 0.0081 0.0068 0.0253
Trypanosoma cruzi AMP-activated protein kinase, gamma regulatory subunit 0.0063 0.0048 0.0135
Schistosoma mansoni microtubule-associated protein tau 0.8956 1 1
Schistosoma mansoni hypothetical protein 0.0104 0.0094 0.0094
Trichomonas vaginalis glutathione reductase, putative 0.0034 0.0015 0.044
Echinococcus multilocularis microtubule associated protein 2 0.8956 1 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0018 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0032 0.1149
Echinococcus multilocularis geminin 0.0183 0.0182 0.018
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0034 0.0015 0.0044
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.002 0.0055
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.1045 0.1147 0.425
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.2429 0.2696 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.0046 0.0044
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0025 0.0005 0.0007
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0114 0.0105 0.0379
Mycobacterium tuberculosis Conserved protein 0.018 0.0179 0.0652
Leishmania major hypothetical protein, conserved 0.018 0.0179 0.0652
Loa Loa (eye worm) hypothetical protein 0.009 0.0078 0.0289
Brugia malayi ancient conserved domain protein 2 0.0063 0.0048 0.0164
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0034 0.0015 0.0044
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.009 0.0079 0.025
Loa Loa (eye worm) hypothetical protein 0.0104 0.0094 0.0349
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0011 0.0019
Brugia malayi Thioredoxin reductase 0.0097 0.0086 0.0307
Brugia malayi LBP / BPI / CETP family, C-terminal domain containing protein 0.0199 0.0201 0.0733
Loa Loa (eye worm) hypothetical protein 0.0152 0.0148 0.0549
Echinococcus granulosus phd:f box containing protein 0.0033 0.0014 0.0012
Mycobacterium tuberculosis Probable oxidoreductase 0.0246 0.0253 0.0927
Onchocerca volvulus 0.0199 0.0201 0.1725
Loa Loa (eye worm) hypothetical protein 0.0023 0.0003 0.0012
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0478 0.0512 0.051
Echinococcus granulosus peptidase Clp S14 family 0.0313 0.0328 0.0326
Onchocerca volvulus 0.0199 0.0201 0.1725
Echinococcus multilocularis neuropeptide s receptor 0.0481 0.0515 0.0513
Loa Loa (eye worm) intermediate filament protein 0.0137 0.013 0.0484
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.009 0.0079 0.0271
Giardia lamblia Hypothetical protein 0.0063 0.0048 0.511
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0313 0.0328 0.1206
Onchocerca volvulus 0.0036 0.0018 0.013
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0081 0.0068 0.0068
Loa Loa (eye worm) hypothetical protein 0.0114 0.0105 0.0391
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0036 0.0018 0.0016
Echinococcus multilocularis SNF4:AMP activated protein kinase gamma subunit 0.0063 0.0048 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.009 0.0079 0.3104
Echinococcus granulosus FTZ F1 alpha 0.0036 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.0085 0.0073 0.027
Mycobacterium tuberculosis Probable cystathionine beta-synthase Cbs (serine sulfhydrase) (beta-thionase) (hemoprotein H-450) 0.0063 0.0048 0.0164
Loa Loa (eye worm) hypothetical protein 0.018 0.0179 0.0664
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0036 0.0018 0.0055
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0044 0.0027 0.0078

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.5623 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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