Detailed information for compound 1456987

Basic information

Technical information
  • TDR Targets ID: 1456987
  • Name: TULIP016380
  • MW: 400.428 | Formula: C20H24N4O5
  • H donors: 0 H acceptors: 4 LogP: 2.91 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1ccc(cc1)Oc1nc2c(n1CCC(C)C)c(=O)n(c(=O)n2C)C
  • InChi: 1S/C20H24N4O5/c1-12(2)10-11-24-15-16(22(3)20(27)23(4)17(15)25)21-19(24)29-14-8-6-13(7-9-14)18(26)28-5/h6-9,12H,10-11H2,1-5H3
  • InChiKey: PRGBMCGFMMBVKT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • MLS000096968
  • SMR000074774
  • methyl 4-{[1,3-dimethyl-7-(3-methylbutyl)-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]oxy}benzoate
  • ZINC01130904

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens survival of motor neuron 2, centromeric Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Rattus norvegicus Inositol monophosphatase 1 Starlite/ChEMBL No references
Homo sapiens nuclear factor, erythroid 2-like 2 Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania mexicana myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium ulcerans extragenic suppressor protein SuhB Get druggable targets OG5_126810 All targets in OG5_126810
Entamoeba histolytica myo-inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania braziliensis myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi hypothetical protein Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Inositol-1 Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus multilocularis survival motor neuron protein 1 Get druggable targets OG5_132873 All targets in OG5_132873
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis myo inositol monophosphatase, putative Get druggable targets OG5_126810 All targets in OG5_126810
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative Get druggable targets OG5_126810 All targets in OG5_126810
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni inositol monophosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Echinococcus granulosus inositol monophosphatase 1 Get druggable targets OG5_126810 All targets in OG5_126810
Neospora caninum hypothetical protein Get druggable targets OG5_126810 All targets in OG5_126810
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase Get druggable targets OG5_126810 All targets in OG5_126810
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma japonicum ko:K01092 myo-inositol-1(or 4)-monophosphatase [EC3.1.3.25], putative Get druggable targets OG5_126810 All targets in OG5_126810
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 307 aa 22.5 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Trypanosoma brucei gambiense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 309 aa 27.8 %
Onchocerca volvulus Inositol monophosphatase 1   277 aa 238 aa 22.7 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase 1 Inositol monophosphatase 1   277 aa 275 aa 22.2 %
Schistosoma japonicum ko:K01082 3'(2'), 5'-bisphosphate nucleotidase [EC3.1.3.7], putative Inositol monophosphatase 1   277 aa 275 aa 21.5 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 258 aa 21.7 %
Onchocerca volvulus Putative 28S ribosomal protein S10, mitochondrial Inositol monophosphatase 1   277 aa 271 aa 46.1 %
Trypanosoma congolense inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 28.9 %
Trichomonas vaginalis diphosphonucleoside phosphohydrolase, putative Inositol monophosphatase 1   277 aa 263 aa 21.7 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 306 aa 22.5 %
Trypanosoma cruzi inositol polyphosphate 1-phosphatase, putative Inositol monophosphatase 1   277 aa 291 aa 23.7 %
Schistosoma mansoni pap-inositol-14-phosphatase Inositol monophosphatase 1   277 aa 279 aa 22.9 %
Trichomonas vaginalis myo inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 276 aa 21.4 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 287 aa 22.3 %
Loa Loa (eye worm) hypothetical protein Inositol monophosphatase 1   277 aa 298 aa 23.8 %
Trypanosoma brucei inositol-1(or 4)-monophosphatase, putative Inositol monophosphatase 1   277 aa 304 aa 27.3 %
Trichomonas vaginalis inositol monophosphatase, putative Inositol monophosphatase 1   277 aa 268 aa 22.4 %
Trypanosoma cruzi myo-inositol-1 phosphatase, putative Inositol monophosphatase 1   277 aa 284 aa 30.6 %
Onchocerca volvulus Putative trans-2-enoyl-CoA reductase 1, mitochondrial Inositol monophosphatase 1   277 aa 278 aa 23.0 %
Brugia malayi Inositol monophosphatase family protein Inositol monophosphatase 1   277 aa 238 aa 21.8 %
Dictyostelium discoideum 3',5'-bisphosphate nucleotidase Inositol monophosphatase 1   277 aa 230 aa 25.2 %
Candida albicans one of two closely related genes similar to S. cerevisiae MET22/HAL2 (YOL064C) bisphosphate-3'-nucleotidase, implicated in salt Inositol monophosphatase 1   277 aa 300 aa 22.0 %
Entamoeba histolytica 3(2),5-bisphosphate nucleotidase, putative Inositol monophosphatase 1   277 aa 263 aa 24.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0817 0.0799
Loa Loa (eye worm) cyclin domain-containing protein 0.0049 0.0875 0.0875
Loa Loa (eye worm) RNA binding protein 0.0126 0.2861 0.2861
Entamoeba histolytica protein kinase, putative 0.0045 0.077 0.0753
Leishmania major mitotic cyclin, putative 0.0049 0.0875 0.0859
Schistosoma mansoni tyrosine kinase 0.0148 0.3427 0.3427
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0107 0.0107
Schistosoma mansoni serine/threonine kinase 0.0021 0.0168 0.0168
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0016 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0049 0.0875 0.0875
Schistosoma mansoni tar DNA-binding protein 0.0126 0.2861 0.2861
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0829 0.0811
Schistosoma mansoni tyrosine kinase 0.0016 0.0026 0.0026
Trichomonas vaginalis cyclin B3, putative 0.0049 0.0875 0.0857
Loa Loa (eye worm) TK/EGFR protein kinase 0.022 0.527 0.527
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.051 0.0491
Echinococcus multilocularis tar DNA binding protein 0.0126 0.2861 0.2861
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0404 1 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0404 1 1
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0018 0.007 0.0051
Schistosoma mansoni tyrosine kinase 0.0143 0.3297 0.3297
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0016 0.0026 0.0026
Echinococcus granulosus tyrosine protein kinase Fyn 0.0016 0.0026 0.0026
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0029 0.037 0.037
Echinococcus granulosus cyclin b3 0.0203 0.4831 0.4831
Trichomonas vaginalis AGC family protein kinase 0.0045 0.077 0.0752
Plasmodium falciparum cyclin dependent kinase binding protein, putative 0.0049 0.0875 0.0859
Echinococcus multilocularis cdk5 and abl1 enzyme substrate 1 0.0049 0.0875 0.0875
Giardia lamblia Hypothetical protein 0.0203 0.4831 0.4595
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.004 0.0643 0.5
Schistosoma mansoni cyclin B3 0.0203 0.4831 0.4831
Trypanosoma brucei cyclin 9 0.0049 0.0875 0.0859
Trypanosoma cruzi CYC2-like cyclin, putative 0.0229 0.5491 0.5482
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0034 0.0491 0.0473
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0107 0.0107
Echinococcus multilocularis cyclin B3 1 0.0203 0.4831 0.4831
Schistosoma mansoni tyrosine kinase 0.0143 0.3297 0.3297
Onchocerca volvulus Cyclin L homolog 0.0049 0.0875 0.0626
Trichomonas vaginalis cyclin B, putative 0.0229 0.5491 0.5482
Brugia malayi Protein kinase domain containing protein 0.0021 0.0168 0.0168
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0203 0.4831 0.4831
Onchocerca volvulus Cyclin L homolog 0.0049 0.0875 0.0626
Loa Loa (eye worm) raf kinase 0.0224 0.5375 0.5375
Echinococcus multilocularis inositol monophosphatase 1 0.0045 0.0763 0.0763
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.1501 0.1486
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0016 0.0026 0.0026
Echinococcus granulosus epidermal growth factor receptor 0.0148 0.3427 0.3427
Entamoeba histolytica hypothetical protein 0.0049 0.0875 0.0859
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0422 0.0403
Trichomonas vaginalis cyclin A, putative 0.0229 0.5491 0.5482
Giardia lamblia Cyclin A 0.0203 0.4831 0.4595
Trichomonas vaginalis cyclin B, putative 0.0229 0.5491 0.5482
Loa Loa (eye worm) hypothetical protein 0.0019 0.0107 0.0107
Toxoplasma gondii cyclin 4, putative 0.0049 0.0875 0.0859
Echinococcus granulosus raf serine:threonine protein kinase 0.0229 0.5505 0.5505
Echinococcus multilocularis cyclin y 0.0049 0.0875 0.0875
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0021 0.0168 0.0168
Echinococcus multilocularis activin receptor type 0.0016 0.0018 0.0018
Onchocerca volvulus Tyrosine kinase homolog 0.0151 0.3496 0.5949
Brugia malayi Protein kinase domain containing protein 0.0189 0.4466 0.4466
Echinococcus granulosus nervana 2 0.0021 0.0165 0.0165
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0049 0.0875 0.0859
Trichomonas vaginalis AGC family protein kinase 0.0045 0.077 0.0752
Schistosoma mansoni serine/threonine protein kinase 0.0404 1 1
Giardia lamblia Hypothetical protein 0.0049 0.0875 0.0459
Brugia malayi Protein kinase domain containing protein 0.0404 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0817 0.0817
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.051 0.0491
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.005 0.0905 0.0888
Schistosoma mansoni tyrosine kinase 0.0143 0.3297 0.3297
Toxoplasma gondii AGC kinase 0.0043 0.0715 0.0698
Trichomonas vaginalis cyclins, putative 0.0049 0.0875 0.0857
Trichomonas vaginalis cyclin B, putative 0.0229 0.5491 0.5482
Trypanosoma cruzi cdc2-related kinase 1 0.0404 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0404 1 1
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0021 0.0168 0.0168
Giardia lamblia G2/mitotic-specific cyclin B 0.0229 0.5491 0.5285
Trichomonas vaginalis cyclin B, putative 0.0049 0.0875 0.0857
Schistosoma mansoni serine/threonine-protein kinase 0.0034 0.0491 0.0491
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.002 0.0001
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.1501 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0675 0.0675
Entamoeba histolytica cyclin, putative 0.0229 0.5491 0.5482
Echinococcus multilocularis Glutaredoxin protein 5 0.0021 0.0165 0.0165
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0404 1 1
Echinococcus multilocularis cyclin b3 0.0203 0.4831 0.4831
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.009 0.009
Trichomonas vaginalis cyclins, putative 0.0049 0.0875 0.0857
Trichomonas vaginalis AGC family protein kinase 0.0021 0.0168 0.0148
Echinococcus granulosus cyclin G2 0.0049 0.0875 0.0875
Loa Loa (eye worm) TK/INSR protein kinase 0.0189 0.4466 0.4466
Plasmodium vivax protein kinase Crk2 0.0404 1 1
Brugia malayi hypothetical protein 0.0043 0.0734 0.0734
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0334 0.0315
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.051 0.0492
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.002 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0572 0.0553
Schistosoma mansoni hypothetical protein 0.0019 0.0107 0.0107
Echinococcus granulosus inositol monophosphatase 1 0.0045 0.0763 0.0763
Brugia malayi Cyclin, N-terminal domain containing protein 0.0049 0.0875 0.0875
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0043 0.0715 0.0715
Trichomonas vaginalis cyclin B3, putative 0.0049 0.0875 0.0857
Echinococcus multilocularis serine:threonine protein kinase N2 0.0021 0.0168 0.0168
Trypanosoma cruzi cyclin 6, putative 0.0229 0.5491 0.5482
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0016 0.0026 0.0026
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.1779 0.1779
Echinococcus multilocularis GPCR, family 2 0.0019 0.0107 0.0107
Loa Loa (eye worm) cyclin domain-containing protein 0.0049 0.0875 0.0875
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.051 0.0491
Echinococcus granulosus cyclins 0.0203 0.4831 0.4831
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0021 0.0165 0.0165
Echinococcus multilocularis rac serine:threonine kinase 0.0034 0.0491 0.0491
Brugia malayi Cyclin, N-terminal domain containing protein 0.0049 0.0875 0.0875
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0116 0.0097
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0265 0.0246
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0043 0.0728 0.0711
Echinococcus multilocularis cyclins 0.0203 0.4831 0.4831
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0334 0.0315
Loa Loa (eye worm) hypothetical protein 0.0026 0.0277 0.0277
Loa Loa (eye worm) cyclin domain-containing protein 0.0049 0.0875 0.0875
Entamoeba histolytica hypothetical protein 0.0043 0.0734 0.0717
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0921 0.0903
Loa Loa (eye worm) hypothetical protein 0.0049 0.0875 0.0875
Brugia malayi Protein kinase domain containing protein 0.0079 0.1654 0.1654
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0021 0.0168 0.0168
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0016 0.002 0.0001
Brugia malayi Protein kinase domain containing protein 0.0045 0.077 0.077
Toxoplasma gondii hypothetical protein 0.0154 0.3573 0.3561
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0016 0.002 0.0001
Loa Loa (eye worm) hypothetical protein 0.0393 0.9729 0.9729
Echinococcus granulosus cyclin A3 4 0.0049 0.0875 0.0875
Brugia malayi Cyclin, N-terminal domain containing protein 0.0049 0.0875 0.0875
Echinococcus multilocularis cyclin A3 4 0.0049 0.0875 0.0875
Loa Loa (eye worm) hypothetical protein 0.006 0.1164 0.1164
Trichomonas vaginalis CMGC family protein kinase 0.0404 1 1
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0817 0.0817
Loa Loa (eye worm) AGC/AKT protein kinase 0.0045 0.077 0.077
Schistosoma mansoni hypothetical protein 0.0049 0.0875 0.0875
Trichomonas vaginalis cyclin D, putative 0.0203 0.4831 0.4821
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0058 0.1114 0.1114
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1779 0.1763
Echinococcus granulosus cyclins 0.0203 0.4831 0.4831
Echinococcus granulosus Glutaredoxin protein 5 0.0021 0.0165 0.0165
Schistosoma mansoni serine/threonine-protein kinase 0.0034 0.0491 0.0491
Entamoeba histolytica cell division protein kinase 2, putative 0.0404 1 1
Echinococcus multilocularis chromobox protein 1 0.0084 0.1779 0.1779
Echinococcus multilocularis geminin 0.0205 0.4875 0.4875
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0168 0.0168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0265 0.0246
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0763 0.0746
Echinococcus granulosus cyclin t1 0.0049 0.0875 0.0875
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0043 0.0728 0.0711
Schistosoma mansoni pyruvate dehydrogenase 0.0124 0.2795 0.2795
Brugia malayi Tyrosine-protein kinase abl-1 0.0016 0.0026 0.0026
Schistosoma mansoni hypothetical protein 0.0205 0.4875 0.4875
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0327 0.0308
Echinococcus multilocularis roundabout 2 0.0015 0.001 0.001
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1501 1
Loa Loa (eye worm) TAR-binding protein 0.0126 0.2861 0.2861
Entamoeba histolytica protein kinase, putative 0.0021 0.0168 0.015
Brugia malayi Protein kinase domain containing protein 0.0018 0.009 0.009
Toxoplasma gondii cyclin dependent kinase binding protein 0.0049 0.0875 0.0859
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0475 0.0456
Entamoeba histolytica cyclin C, putative 0.0049 0.0875 0.0859
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.037 0.037
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0734 0.0734
Echinococcus granulosus chromobox protein 1 0.0084 0.1779 0.1779
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1501 0.1501
Schistosoma mansoni chromobox protein 0.0084 0.1779 0.1779
Echinococcus multilocularis cyclin y 0.0049 0.0875 0.0875
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.1501 0.1486
Echinococcus granulosus Cyclin L1 0.0049 0.0875 0.0875
Echinococcus granulosus cyclin dependent kinase 5 0.0404 1 1
Echinococcus granulosus chromobox protein 1 0.0084 0.1779 0.1779
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0572 0.0553
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.1164 0.1164
Echinococcus multilocularis cyclins 0.0203 0.4831 0.4831
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0817 0.0799
Loa Loa (eye worm) hypothetical protein 0.0047 0.0829 0.0829
Brugia malayi hypothetical protein 0.0286 0.6955 0.6955
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.1501 0.1501
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0875 0.0857
Echinococcus granulosus c src tyrosine kinase 0.0016 0.0026 0.0026
Loa Loa (eye worm) cyclin domain-containing protein 0.0203 0.4831 0.4831
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0021 0.0168 0.0168
Schistosoma mansoni protein kinase 0.0016 0.0018 0.0018
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0016 0.0026 0.0026
Trichomonas vaginalis cyclins, putative 0.0229 0.5491 0.5482
Entamoeba histolytica PH domain containing protein kinase, putative 0.0034 0.0491 0.0473
Trypanosoma cruzi mitotic cyclin, putative 0.0049 0.0875 0.0859
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0018 0.009 0.009
Loa Loa (eye worm) MH2 domain-containing protein 0.0137 0.3143 0.3143
Echinococcus granulosus serine threonine protein kinase nrc 0.0032 0.0436 0.0436
Brugia malayi Cyclin, N-terminal domain containing protein 0.0049 0.0875 0.0875
Echinococcus granulosus oligomeric golgi complex subunit 3 0.0049 0.0875 0.0875
Echinococcus multilocularis cyclins 0.0203 0.4831 0.4831
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.037 0.037
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0016 0.0026 0.0026
Brugia malayi protein kinase C3,putative 0.0018 0.009 0.009
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.6804 0.6804
Schistosoma mansoni cyclins 0.0203 0.4831 0.4831
Schistosoma mansoni pyruvate dehydrogenase 0.0117 0.2618 0.2618
Trypanosoma cruzi cdc2-related kinase 3 0.0404 1 1
Brugia malayi SRC-1 0.0016 0.0026 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0264 0.0245
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0124 0.2795 0.2795
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0016 0.002 0.0001
Schistosoma mansoni cyclin B 0.0229 0.5491 0.5491
Echinococcus multilocularis chromobox protein 1 0.0084 0.1779 0.1779
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0124 0.2795 0.2782
Schistosoma mansoni cyclin k 0.0049 0.0875 0.0875
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0045 0.0763 0.0746
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0021 0.0168 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0875 0.0857
Trypanosoma brucei cyclin 3 0.0049 0.0875 0.0859
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0029 0.037 0.037
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0043 0.0728 0.0711
Brugia malayi Cyclin, N-terminal domain containing protein 0.0049 0.0875 0.0875
Loa Loa (eye worm) cyclin domain-containing protein 0.0049 0.0875 0.0875
Onchocerca volvulus Protein CNPPD1 homolog 0.0049 0.0875 0.0626
Onchocerca volvulus 0.0049 0.0875 0.0626
Brugia malayi Hr1 repeat family protein 0.0021 0.0168 0.0168
Echinococcus granulosus twitchin 0.0023 0.0201 0.0201
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0763 0.0745
Giardia lamblia Kinase, CMGC CDK 0.0404 1 1
Echinococcus granulosus activin receptor type 0.0016 0.0018 0.0018
Trichomonas vaginalis cyclin B, putative 0.0229 0.5491 0.5482
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.051 0.0491
Schistosoma mansoni cyclin G2 0.0049 0.0875 0.0875
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0168 0.0168
Loa Loa (eye worm) AGC/PKN protein kinase 0.0021 0.0168 0.0168
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.1164 0.1164
Brugia malayi hypothetical protein 0.0049 0.0875 0.0875
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0404 1 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0016 0.0026 0.0026
Brugia malayi Immunoglobulin I-set domain containing protein 0.0161 0.3762 0.3762
Echinococcus granulosus cyclin G2 0.0049 0.0875 0.0875
Loa Loa (eye worm) CYL-1 protein 0.0049 0.0875 0.0875
Echinococcus granulosus Protein kinase C brain isozyme 0.0029 0.037 0.037
Loa Loa (eye worm) hypothetical protein 0.0124 0.2795 0.2795
Echinococcus granulosus survival motor neuron protein 1 0.0286 0.6955 0.6955
Brugia malayi Cyclin, N-terminal domain containing protein 0.0203 0.4831 0.4831
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0032 0.0436 0.0418
Trypanosoma cruzi cyclin, putative 0.0229 0.5491 0.5482
Leishmania major developmentally regulated phosphoprotein-like protein 0.0124 0.2795 0.2782
Trichomonas vaginalis cyclins, putative 0.0229 0.5491 0.5482
Brugia malayi protein kinase C II. 0.0029 0.037 0.037
Echinococcus granulosus tyrosine protein kinase Src64B 0.0016 0.0026 0.0026
Schistosoma mansoni tyrosine kinase 0.0016 0.0026 0.0026
Echinococcus granulosus retinoblastoma protein 1 0.0084 0.1769 0.1769
Loa Loa (eye worm) hypothetical protein 0.0056 0.106 0.106
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.002 0.002
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0168 0.0168
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0817 0.0799
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0572 0.0553
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0573 0.0555
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0817 0.08
Echinococcus multilocularis c src tyrosine kinase 0.0016 0.0026 0.0026
Schistosoma mansoni cyclin d 0.0049 0.0875 0.0875
Echinococcus multilocularis protein kinase c epsilon type 0.0029 0.037 0.037
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0572 0.0553
Schistosoma mansoni tyrosine kinase 0.022 0.527 0.527
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.002 0.002
Trypanosoma brucei mitotic cyclin 0.0049 0.0875 0.0859
Echinococcus multilocularis tyrosine protein kinase Abl 0.0016 0.0026 0.0026
Brugia malayi kinase, mitochondrial precursor 0.0124 0.2795 0.2795
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0734 0.0734
Loa Loa (eye worm) hypothetical protein 0.0037 0.0567 0.0567
Echinococcus granulosus tar DNA binding protein 0.0126 0.2861 0.2861
Schistosoma mansoni g1/s-specific cyclin C 0.0049 0.0875 0.0875
Loa Loa (eye worm) transcription factor SMAD2 0.0137 0.3143 0.3143
Brugia malayi MH2 domain containing protein 0.0137 0.3143 0.3143
Loa Loa (eye worm) cyclin C 0.0049 0.0875 0.0875
Echinococcus granulosus geminin 0.0205 0.4875 0.4875
Loa Loa (eye worm) hypothetical protein 0.0049 0.0875 0.0875
Trichomonas vaginalis cyclin B, putative 0.0203 0.4831 0.4821
Echinococcus granulosus cyclin B 0.0229 0.5491 0.5491
Echinococcus multilocularis retinoblastoma protein 1 0.0084 0.1769 0.1769
Trichomonas vaginalis AGC family protein kinase 0.0045 0.077 0.0752
Brugia malayi Protein kinase domain containing protein 0.0021 0.0168 0.0168
Echinococcus multilocularis Cyclin L1 0.0049 0.0875 0.0875
Loa Loa (eye worm) AGC/NDR protein kinase 0.0021 0.0168 0.0168
Onchocerca volvulus 0.0058 0.1114 0.111
Echinococcus granulosus cyclins 0.0049 0.0875 0.0875
Loa Loa (eye worm) SRC-1 0.0016 0.0026 0.0026
Toxoplasma gondii cyclin, N-terminal domain-containing protein 0.0049 0.0875 0.0859
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.051 0.0491
Giardia lamblia Cyclin fold protein 1, putative 0.0049 0.0875 0.0459
Plasmodium vivax hypothetical protein, conserved 0.0049 0.0875 0.0459
Echinococcus multilocularis cyclin G2 0.0049 0.0875 0.0875
Echinococcus granulosus serine/threonine protein kinase 0.0034 0.0491 0.0491
Plasmodium falciparum cyclin 1 0.0049 0.0875 0.0859
Trichomonas vaginalis AGC family protein kinase 0.0045 0.077 0.0752
Echinococcus granulosus nervana 2 0.0021 0.0165 0.0165
Trichomonas vaginalis AGC family protein kinase 0.0024 0.0223 0.0203
Leishmania major mitotic cyclin, putative 0.0049 0.0875 0.0859
Schistosoma mansoni hypothetical protein 0.0205 0.4875 0.4875
Leishmania major cyclin 0.0229 0.5491 0.5482
Trypanosoma cruzi Protein kinase B 0.0034 0.0491 0.0473
Trichomonas vaginalis AGC family protein kinase 0.0045 0.077 0.0752
Schistosoma mansoni tyrosine kinase 0.0148 0.3427 0.3427
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0829 0.0532
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0107 0.0107
Echinococcus granulosus serine:threonine protein kinase N2 0.0021 0.0168 0.0168
Loa Loa (eye worm) inositol-1 0.0045 0.0763 0.0763
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Trichomonas vaginalis cyclins, putative 0.0203 0.4831 0.4821
Schistosoma mansoni survival motor neuron protein 0.0058 0.1114 0.1114
Brugia malayi Furin-like cysteine rich region family protein 0.022 0.527 0.527
Echinococcus granulosus cyclins 0.0203 0.4831 0.4831
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0197 0.4686 0.4686
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0817 0.0817
Schistosoma mansoni hypothetical protein 0.0084 0.1769 0.1769
Trichomonas vaginalis cyclins, putative 0.0229 0.5491 0.5482
Schistosoma mansoni tyrosine kinase 0.0189 0.4466 0.4466
Giardia lamblia Kinase, CMGC CDK 0.0404 1 1
Echinococcus multilocularis 0.0066 0.1307 0.1307
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0817 0.08
Schistosoma mansoni serine/threonine protein kinase 0.0018 0.009 0.009
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0016 0.0026 0.0026
Schistosoma mansoni serine/threonine protein kinase 0.0029 0.037 0.037
Entamoeba histolytica protein kinase, putative 0.0045 0.077 0.0753
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0264 0.0245
Trichomonas vaginalis cyclin A, putative 0.0049 0.0875 0.0857
Trichomonas vaginalis conserved hypothetical protein 0.0203 0.4831 0.4821
Echinococcus granulosus cyclin y 0.0049 0.0875 0.0875
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.001
Echinococcus multilocularis nervana 2 0.0021 0.0165 0.0165
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0817 0.0817
Trichomonas vaginalis AGC family protein kinase 0.0045 0.077 0.0752
Echinococcus granulosus cyclins 0.0203 0.4831 0.4831
Entamoeba histolytica PH domain containing protein kinase, putative 0.0034 0.0491 0.0473
Entamoeba histolytica cyclin, domain containing protein 0.0049 0.0875 0.0859
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0021 0.0168 0.0168
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0161 0.3762 0.3762
Echinococcus granulosus cyclin 0.0049 0.0875 0.0875
Echinococcus multilocularis cyclin dependent kinase 1 0.0404 1 1
Onchocerca volvulus 0.0143 0.3303 0.5557
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0189 0.4466 0.4466
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0829 0.0811
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.051 0.0491
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0817 0.0817
Brugia malayi Cyclin, N-terminal domain containing protein 0.0049 0.0875 0.0875
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0817 0.08
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0817 0.08
Trichomonas vaginalis CMGC family protein kinase 0.0404 1 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0763 0.0746
Loa Loa (eye worm) cyclin domain-containing protein 0.0049 0.0875 0.0875
Leishmania major cyclin 9, putative 0.0049 0.0875 0.0859
Brugia malayi Raf kinase 0.0221 0.5303 0.5303
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0817 0.08
Schistosoma mansoni protein kinase 0.0016 0.0018 0.0018
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0763 0.0746
Echinococcus granulosus cyclins 0.0203 0.4831 0.4831
Schistosoma mansoni atypical protein kinase C 0.0029 0.037 0.037
Brugia malayi STAT protein, DNA binding domain containing protein 0.0168 0.3933 0.3933
Brugia malayi RNA binding protein 0.0126 0.2861 0.2861
Echinococcus multilocularis serine threonine protein kinase 0.0021 0.0168 0.0168
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0734 0.0734
Trichomonas vaginalis AGC family protein kinase 0.0021 0.0168 0.0148
Brugia malayi chromobox protein homolog 3 0.0047 0.0829 0.0829
Giardia lamblia Hypothetical protein 0.0049 0.0875 0.0459
Echinococcus multilocularis serine:threonine protein kinase N2 0.0021 0.0168 0.0168
Trypanosoma cruzi cyclin 9, putative 0.0049 0.0875 0.0859
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0018 0.009 0.009
Brugia malayi Cyclin, N-terminal domain containing protein 0.0229 0.5491 0.5491
Trichomonas vaginalis cyclin D, putative 0.0049 0.0875 0.0857
Trichomonas vaginalis cyclins, putative 0.0229 0.5491 0.5482
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0016 0.0026 0.0026
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0817 0.08
Trichomonas vaginalis cyclin B, putative 0.0049 0.0875 0.0857
Schistosoma mansoni Cyclin fold protein 0.0049 0.0875 0.0875
Entamoeba histolytica protein kinase, putative 0.0018 0.007 0.0051
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0032 0.0436 0.0418
Echinococcus granulosus GPCR family 2 0.0019 0.0107 0.0107
Entamoeba histolytica protein kinase 2, putative 0.0032 0.0436 0.0418
Echinococcus granulosus tyrosine protein kinase Src42A 0.0016 0.0026 0.0026
Trichomonas vaginalis CMGC family protein kinase 0.0404 1 1
Echinococcus granulosus tyrosine protein kinase Lyn 0.0026 0.0297 0.0297
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0045 0.0763 0.0746
Plasmodium vivax cyclin 4, putative 0.0049 0.0875 0.0459
Plasmodium vivax cyclin homologue, putative 0.0049 0.0875 0.0459
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0573 0.0555
Echinococcus multilocularis cyclin B 0.0229 0.5491 0.5491
Trichomonas vaginalis AGC family protein kinase 0.0021 0.0168 0.0148
Brugia malayi Cyclin C 0.0049 0.0875 0.0875
Loa Loa (eye worm) hypothetical protein 0.0041 0.0675 0.0675
Trypanosoma cruzi cdc2-related kinase 3 0.0404 1 1
Schistosoma mansoni cyclin G 0.0049 0.0875 0.0875
Trichomonas vaginalis inositol monophosphatase, putative 0.0045 0.0763 0.0745
Echinococcus granulosus roundabout 2 0.0015 0.001 0.001
Trypanosoma brucei mitotic cyclin 6 0.0229 0.5491 0.5482
Loa Loa (eye worm) hypothetical protein 0.0286 0.6955 0.6955
Schistosoma mansoni hypothetical protein 0.0019 0.0107 0.0107
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0018 0.009 0.009
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0573 0.0555
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.0016 0.0033 0.0033
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0203 0.4831 0.4831
Trypanosoma brucei cyclin dependent kinase-binding protein, putative 0.0049 0.0875 0.0859
Loa Loa (eye worm) hypothetical protein 0.0052 0.0947 0.0947
Schistosoma mansoni tyrosine kinase 0.0016 0.0026 0.0026
Trypanosoma brucei cdc2-related kinase 1 0.0404 1 1
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0132 0.2999 0.2999
Schistosoma mansoni pyruvate dehydrogenase 0.0117 0.2618 0.2618
Leishmania major phosphatidylinositol 3-kinase, putative 0.0016 0.002 0.0001
Brugia malayi TAR-binding protein 0.0126 0.2861 0.2861
Echinococcus multilocularis epidermal growth factor receptor 0.0148 0.3427 0.3427
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.0229 0.5491 0.5482
Entamoeba histolytica cyclin family protein 0.0203 0.4831 0.4821
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0032 0.0436 0.0436
Schistosoma mansoni cyclin l 0.0049 0.0875 0.0875
Entamoeba histolytica cyclin family protein 0.0203 0.4831 0.4821
Entamoeba histolytica cyclin, putative 0.0203 0.4831 0.4821
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0016 0.0018 0.0018
Echinococcus multilocularis cyclin dependent kinase 1 0.0404 1 1
Echinococcus multilocularis cyclin k 0.0049 0.0875 0.0875
Schistosoma mansoni tar DNA-binding protein 0.0126 0.2861 0.2861
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0107 0.0107
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0875 0.0857
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.1501 0.1501
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0197 0.4686 0.4686
Brugia malayi RNA recognition motif domain containing protein 0.0126 0.2861 0.2861
Echinococcus granulosus cdk5 and abl1 enzyme substrate 1 0.0049 0.0875 0.0875
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0875 0.0857
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.051 0.0491
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0021 0.0168 0.0168
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0396 0.0377
Schistosoma mansoni inositol monophosphatase 0.0045 0.0763 0.0763
Echinococcus granulosus protein kinase C gamma type 0.0021 0.0168 0.0168
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0921 0.0719
Schistosoma mansoni hypothetical protein 0.0019 0.0107 0.0107
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.1164 0.1164
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0327 0.0308
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0021 0.0165 0.0165
Schistosoma mansoni tar DNA-binding protein 0.0126 0.2861 0.2861
Echinococcus granulosus protein kinase c epsilon type 0.0029 0.037 0.037
Brugia malayi cyclin fold protein 1 variant b 0.0049 0.0875 0.0875
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1501 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.1501 0.1501
Trichomonas vaginalis AGC family protein kinase 0.0045 0.077 0.0752
Echinococcus multilocularis cyclin G2 0.0049 0.0875 0.0875
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0404 1 1
Plasmodium vivax cyclin dependent kinase binding protein, putative 0.0049 0.0875 0.0459
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0018 0.009 0.009
Trypanosoma brucei cdc2-related kinase 3 0.0404 1 1
Entamoeba histolytica hypothetical protein 0.0043 0.0734 0.0717
Echinococcus granulosus cyclin B3 1 0.0203 0.4831 0.4831
Loa Loa (eye worm) hypothetical protein 0.0229 0.5491 0.5491
Echinococcus multilocularis serine:threonine protein kinase 38 0.0021 0.0168 0.0168
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0126 0.2861 0.2861
Brugia malayi p70 ribosomal S6 kinase beta 0.0043 0.0715 0.0715
Loa Loa (eye worm) cyclin domain-containing protein 0.0049 0.0875 0.0875
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0148 0.3427 0.3427
Schistosoma mansoni tar DNA-binding protein 0.0126 0.2861 0.2861
Echinococcus granulosus cyclin k 0.0049 0.0875 0.0875
Trypanosoma brucei developmentally regulated phosphoprotein 0.0124 0.2795 0.2782
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.002 0.002
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0642 0.0623
Schistosoma mansoni hypothetical protein 0.0041 0.0675 0.0675
Plasmodium falciparum protein kinase 5 0.0404 1 1
Echinococcus multilocularis cyclin dependent kinase 5 0.0404 1 1
Trichomonas vaginalis cyclin D, putative 0.0203 0.4831 0.4821
Echinococcus multilocularis raf serine:threonine protein kinase 0.0229 0.5505 0.5505
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0124 0.2795 0.2795
Echinococcus multilocularis G1:S specific cyclin D1 0.0049 0.0875 0.0875
Schistosoma mansoni hypothetical protein 0.0019 0.0107 0.0107
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0404 1 1
Brugia malayi Protein kinase c protein 2 0.0018 0.009 0.009
Echinococcus granulosus cyclin dependent kinase 1 0.0404 1 1
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1779 0.1763
Loa Loa (eye worm) STAT protein 0.0168 0.3933 0.3933
Brugia malayi hypothetical protein 0.0049 0.0875 0.0875
Loa Loa (eye worm) hypothetical protein 0.0021 0.0168 0.0168
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0475 0.0456
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0045 0.0763 0.5
Loa Loa (eye worm) hypothetical protein 0.0074 0.1524 0.1524
Echinococcus multilocularis cyclins 0.0203 0.4831 0.4831
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0921 0.0903
Toxoplasma gondii cyclin domain protein, cyclin H family protein 0.0049 0.0875 0.0859
Loa Loa (eye worm) cyclin fold protein 1 variant b 0.0049 0.0875 0.0875
Schistosoma mansoni proteasome subunit alpha 1 (T01 family) 0.0049 0.0875 0.0875
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0032 0.0436 0.0436
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0021 0.0168 0.0168
Entamoeba histolytica hypothetical protein 0.0043 0.0734 0.0717
Brugia malayi Retinoblastoma-associated protein A domain containing protein 0.0084 0.1769 0.1769
Schistosoma mansoni tyrosine kinase 0.0016 0.0026 0.0026
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0021 0.0168 0.0168
Trypanosoma cruzi cyclin, putative 0.0229 0.5491 0.5482
Echinococcus multilocularis cyclins 0.0203 0.4831 0.4831
Schistosoma mansoni protein kinase 0.0016 0.0018 0.0018
Entamoeba histolytica protein kinase, putative 0.0043 0.0715 0.0698
Giardia lamblia Cyclin B-like protein 0.0049 0.0875 0.0459
Entamoeba histolytica hypothetical protein 0.0043 0.0734 0.0717
Schistosoma mansoni tar DNA-binding protein 0.0126 0.2861 0.2861
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0045 0.0763 0.0746
Schistosoma mansoni chromobox protein 0.0084 0.1779 0.1779
Echinococcus multilocularis cyclin t1 0.0049 0.0875 0.0875
Loa Loa (eye worm) hypothetical protein 0.0229 0.5491 0.5491
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0572 0.0553
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0016 0.0026 0.0026
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0045 0.0763 0.0745
Echinococcus multilocularis cyclins 0.0203 0.4831 0.4831
Trypanosoma cruzi mitotic cyclin, putative 0.0049 0.0875 0.0859
Schistosoma mansoni hypothetical protein 0.0043 0.0734 0.0734
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0107 0.0107
Echinococcus multilocularis protein kinase c iota type 0.0029 0.037 0.037
Echinococcus granulosus NDR protein kinase 0.0021 0.0168 0.0168
Echinococcus multilocularis epidermal growth factor receptor 0.022 0.527 0.527
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0107 0.0107
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0265 0.0246
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0185 0.0167
Echinococcus granulosus cyclin y 0.0049 0.0875 0.0875
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0197 0.4686 0.4686
Brugia malayi Cyclin, N-terminal domain containing protein 0.0229 0.5491 0.5491
Toxoplasma gondii hypothetical protein 0.0049 0.0875 0.0859
Trichomonas vaginalis cyclins, putative 0.0075 0.1535 0.1518
Trypanosoma cruzi hypothetical protein, conserved 0.0049 0.0875 0.0859
Echinococcus multilocularis oligomeric golgi complex subunit 3 0.0049 0.0875 0.0875
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0404 1 1
Onchocerca volvulus 0.0229 0.5491 1
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0016 0.0018 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0264 0.0245
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0189 0.4466 0.4466
Schistosoma mansoni protein kinase C mu 0.0018 0.009 0.009
Echinococcus multilocularis nervana 2 0.0021 0.0165 0.0165
Brugia malayi Heterochromatin protein 1 0.0084 0.1779 0.1779
Trypanosoma cruzi cdc2-related kinase 1 0.0404 1 1
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0016 0.0026 0.0026
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0016 0.0026 0.0026
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0817 0.08
Brugia malayi Cyclin, N-terminal domain containing protein 0.0049 0.0875 0.0875
Giardia lamblia GTOR 0.0047 0.0817 0.0399
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0124 0.2795 0.2795
Echinococcus granulosus tyrosine protein kinase Fyn 0.0016 0.0026 0.0026
Echinococcus granulosus epidermal growth factor receptor 0.022 0.527 0.527
Echinococcus multilocularis survival motor neuron protein 1 0.0286 0.6955 0.6955
Schistosoma mansoni serine/threonine protein kinase 0.0229 0.5505 0.5505
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.002 0.0001
Schistosoma mansoni serine/threonine protein kinase 0.0021 0.0168 0.0168
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0016 0.0026 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0265 0.0246
Echinococcus multilocularis cyclin dependent kinase 0.0404 1 1
Trypanosoma brucei rac serine-threonine kinase, putative 0.0045 0.077 0.0753
Echinococcus multilocularis cyclin 0.0049 0.0875 0.0875
Echinococcus granulosus tyrosine protein kinase Fyn 0.0016 0.0026 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0334 0.0315
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0043 0.0728 0.0711
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0107 0.0107
Brugia malayi C1-like domain containing protein 0.0018 0.009 0.009
Echinococcus multilocularis cyclins 0.0203 0.4831 0.4831
Brugia malayi follicle stimulating hormone receptor 0.028 0.6804 0.6804
Entamoeba histolytica cyclin, domain containing protein 0.0049 0.0875 0.0859
Schistosoma mansoni vav2 0.0017 0.0055 0.0055
Trichomonas vaginalis cyclin B3, putative 0.0203 0.4831 0.4821
Plasmodium falciparum cyclin 0.0203 0.4831 0.4821
Schistosoma mansoni serine/threonine protein kinase 0.0197 0.4686 0.4686
Entamoeba histolytica cell division protein kinase 2, putative 0.0404 1 1
Schistosoma mansoni hypothetical protein 0.0058 0.1114 0.1114
Echinococcus granulosus insulin receptor 0.0189 0.4466 0.4466
Echinococcus multilocularis insulin receptor 0.0189 0.4466 0.4466
Echinococcus granulosus protein kinase c iota type 0.0029 0.037 0.037
Brugia malayi map kinase activated protein kinase protein 2 0.0197 0.4686 0.4686
Brugia malayi Inositol-1 0.0045 0.0763 0.0763
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.002 0.002
Echinococcus granulosus G1:S specific cyclin D1 0.0049 0.0875 0.0875
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.1501 1
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.0018 0.009 0.009
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0016 0.0026 0.0026
Schistosoma mansoni inositol monophosphatase 0.0045 0.0763 0.0763
Echinococcus granulosus cyclin dependent kinase 0.0404 1 1
Schistosoma mansoni tyrosine kinase 0.0189 0.4466 0.4466
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0817 0.08

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 0.0447 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 0.1 uM PUBCHEM_BIOASSAY: Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1): Follow up Confirmation and Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1030, AID2407] ChEMBL. No reference
Potency (functional) 0.1636 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) = 0.3162 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors: Potentiation with Lithium. (Class of assay: confirmatory) [Related pubchem assays: 901 ] ChEMBL. No reference
Potency (functional) 2.0787 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 2.5119 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 5.6234 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) = 11.2202 um PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 15.8489 um PUBCHEM_BIOASSAY: qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (without detergent). (Class of assay: confirmatory) [Related pubchem assays: 2158 (Confirmation qHTS Assay for Inhibitors of Cruzain), 2249 (Probe Development Summary of Promiscuous Inhibitors (Artifacts) of Cruzain), 2161 (qHTS Assay for Inhibitors of Papain: Counterscreen for Cruzain Assay), 1478 (qHTS Assay for Promiscuous and Specific Inhibitors of Cruzain (with detergent))] ChEMBL. No reference
Potency (functional) 125.8925 uM PubChem BioAssay. qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): primary screen. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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