AC50 (functional)
|
= 1.029 uM
|
PUBCHEM_BIOASSAY: Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504596]
|
ChEMBL.
|
No reference
|
AC50 (functional)
|
= 1.351 uM
|
PUBCHEM_BIOASSAY: HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504596]
|
ChEMBL.
|
No reference
|
AC50 (functional)
|
= 1.687 uM
|
PUBCHEM_BIOASSAY: Lymphoblastoid Cells (LCL) Cytotoxicity Secondary Assay Measured in Cell-Based System Using Plate Reader - 2122-03_Inhibitor_Dose_CherryPick_Activity_Set2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504586]
|
ChEMBL.
|
No reference
|
AC50 (functional)
|
= 1.765 uM
|
PUBCHEM_BIOASSAY: Viability counterscreen of potential LMP-1 inhibitors in HEK293 cell background Measured in Cell-Based System Using Plate Reader - 2122-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504586]
|
ChEMBL.
|
No reference
|
AC50 (functional)
|
= 2.11 uM
|
PUBCHEM_BIOASSAY: Inhibitors of Epstein-Barr LMP1 inducible NF-kappaB luciferase reporter Measured in Cell-Based System Using Plate Reader - 2122-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504586]
|
ChEMBL.
|
No reference
|
Activity (ADMET)
|
0
|
Cytotoxicity against mouse ScN2a cells at 100 uM
|
ChEMBL.
|
16987659
|
Activity (ADMET)
|
0
|
Cytotoxicity against prion Fukuoka1 strain infected mouse N2a#58 cells cells at 100 uM
|
ChEMBL.
|
16987659
|
CC50 |
= 12.56 uM
|
NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7)
|
ChEMBL.
|
18579783
|
EC50 (binding)
|
= 4.2
|
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
|
ChEMBL.
|
22957890
|
EC50 (binding)
|
= 4.5
|
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
|
ChEMBL.
|
22957890
|
EC50 (binding)
|
= 5.3
|
Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis
|
ChEMBL.
|
22957890
|
EC50 (functional)
|
= 0.0392 uM
|
NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay
|
ChEMBL.
|
18579783
|
EC50 (functional)
|
= 0.1545 uM
|
NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay
|
ChEMBL.
|
18579783
|
EC50 (functional)
|
= 0.521 uM
|
PUBCHEM_BIOASSAY: Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1979, AID2007]
|
ChEMBL.
|
No reference
|
EC50 (functional)
|
= 4.315 um
|
PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT-LT-ST RAS-Independent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)]
|
ChEMBL.
|
No reference
|
EC50 (functional)
|
= 4.874 um
|
PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Confirmation HTS to Identify Compounds Cytotoxic to BJeLR RAS-Dependent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)]
|
ChEMBL.
|
No reference
|
EC50 (binding)
|
= 4.9 uM
|
Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysis
|
ChEMBL.
|
22957890
|
EC50 (functional)
|
= 11.204 um
|
PUBCHEM_BIOASSAY: Luminescence Cell-Based Dose Response HTS to Identify Compounds Cytotoxic to BJ-TERT RAS-Independent Fibroblast. (Class of assay: confirmatory) [Related pubchem assays: 1674 (Project Summary), 1554 (Primary HTS)]
|
ChEMBL.
|
No reference
|
EC50 (functional)
|
= 16.8 uM
|
PUBCHEM_BIOASSAY: Dose Response concentration confirmation of uHTS hits from a small molecule activators of human intestinal alkaline phosphatase via a luminescent assay. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2524, AID2571]
|
ChEMBL.
|
No reference
|
EC50 (functional)
|
25.3 uM
|
PUBCHEM_BIOASSAY: Dose Response concentration confirmation of uHTS hits from a small molecule activators of human intestinal alkaline phosphatase via a luminescent assay - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2524, AID2571]
|
ChEMBL.
|
No reference
|
EC50 (functional)
|
= 27.1 uM
|
PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Placental Alkaline Phosphatase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2524, AID2571]
|
ChEMBL.
|
No reference
|
EC50 (functional)
|
= 27.5 uM
|
PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS activators of Human Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2524, AID2571]
|
ChEMBL.
|
No reference
|
EC50 (binding)
|
= 29 uM
|
Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis
|
ChEMBL.
|
22957890
|
EC50 (binding)
|
= 64 uM
|
Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation counting analysis
|
ChEMBL.
|
22957890
|
FC (binding)
|
= 2.7
|
Allosteric modulation at human CCR8 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation counting analysis relative to basal level
|
ChEMBL.
|
22957890
|
GI50 (functional)
|
-6.761
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
-6.743
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
-6.705
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
-6.49
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
-6.414
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
-6.356
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
-6.292
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
-6.2
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
-6.123
|
PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
GI50 (functional)
|
= 0.000097 ug ml-1
|
Antitumor cytotoxic activity of the compound against A-498 cell line was determined
|
ChEMBL.
|
11551772
|
GI50 (functional)
|
= 0.000097 ug ml-1
|
Antitumor cytotoxic activity of the compound against A-498 cell line was determined
|
ChEMBL.
|
11551772
|
GI50 (functional)
|
= 0.00073 ug ml-1
|
Antitumor cytotoxic activity of the compound against PC-3 cell line was determined
|
ChEMBL.
|
11551772
|
GI50 (functional)
|
= 0.00073 ug ml-1
|
Antitumor cytotoxic activity of the compound against PC-3 cell line was determined
|
ChEMBL.
|
11551772
|
GI50 (functional)
|
= 0.0026 ug ml-1
|
Antitumor cytotoxic activity of the compound against HT-29 cell line was determined
|
ChEMBL.
|
11551772
|
GI50 (functional)
|
= 0.0026 ug ml-1
|
Antitumor cytotoxic activity of the compound against HT-29 cell line was determined
|
ChEMBL.
|
11551772
|
GI50 (functional)
|
= 0.014 ug ml-1
|
Antitumor cytotoxic activity of the compound against RPTEC cell line was determined
|
ChEMBL.
|
11551772
|
GI50 (functional)
|
= 0.014 ug ml-1
|
Antitumor cytotoxic activity of the compound against RPTEC cell line was determined
|
ChEMBL.
|
11551772
|
GI50 (functional)
|
= 0.071 ug ml-1
|
Antitumor cytotoxic activity of the compound against HCT-15 cell line was determined
|
ChEMBL.
|
11551772
|
GI50 (functional)
|
= 0.07100000000000001 ug ml-1
|
Antitumor cytotoxic activity of the compound against HCT-15 cell line was determined
|
ChEMBL.
|
11551772
|
GI50 (functional)
|
= 0.072 ug ml-1
|
Antitumor cytotoxic activity of the compound against SK-OV-3 cell line was determined
|
ChEMBL.
|
11551772
|
GI50 (functional)
|
= 0.07200000000000001 ug ml-1
|
Antitumor cytotoxic activity of the compound against SK-OV-3 cell line was determined
|
ChEMBL.
|
11551772
|
GI50 (functional)
|
= 0.09 ug ml-1
|
Antitumor cytotoxic activity of the compound against A-549 cell line was determined
|
ChEMBL.
|
11551772
|
GI50 (functional)
|
= 0.09 ug ml-1
|
Antitumor cytotoxic activity of the compound against A-549 cell line was determined
|
ChEMBL.
|
11551772
|
GI50 (functional)
|
= 0.1 ug ml-1
|
Antitumor cytotoxic activity of the compound against SK-MEL-2 cell line was determined
|
ChEMBL.
|
11551772
|
GI50 (functional)
|
= 0.1 ug ml-1
|
Antitumor cytotoxic activity of the compound against SK-MEL-2 cell line was determined
|
ChEMBL.
|
11551772
|
IC50 (binding)
|
= 4.6
|
Displacement of [125I]-CCL3 from human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
|
ChEMBL.
|
22957890
|
IC50 (functional)
|
0
|
Inhibition of PrP-res formation in mouse ScN2a cells relative to control
|
ChEMBL.
|
16987659
|
IC50 (functional)
|
0
|
Inhibition of PrP-res formation in prion Fukuoka1 strain infected mouse N2a#58 cells relative to control
|
ChEMBL.
|
16987659
|
IC50 (functional)
|
= 0.08 uM
|
Cytotoxicity against human SK-OV3 cells after 48 hrs
|
ChEMBL.
|
17673337
|
IC50 (functional)
|
= 0.125 uM
|
cytotoxic activity toward A2780 ovarian human cell line sensitive (S) to cisplatin in experiment 1
|
ChEMBL.
|
11000008
|
IC50 (functional)
|
= 0.125 uM
|
cytotoxic activity toward A2780 ovarian human cell line sensitive (S) to cisplatin in experiment 1
|
ChEMBL.
|
11000008
|
IC50 (functional)
|
= 0.18 uM
|
Cytotoxicity against human SK-MEL-2 cells after 48 hrs
|
ChEMBL.
|
17673337
|
IC50 (functional)
|
= 0.23 uM
|
Cytotoxicity against human HCT15 cells after 48 hrs
|
ChEMBL.
|
17673337
|
IC50 (functional)
|
= 0.25 uM
|
Cytotoxicity against human A549 cells after 48 hrs
|
ChEMBL.
|
17673337
|
IC50 (functional)
|
= 0.36 uM
|
cytotoxic activity toward A2780 ovarian human cell line resistant (R) to cisplatin in experiment 2
|
ChEMBL.
|
11000008
|
IC50 (functional)
|
= 0.36 uM
|
cytotoxic activity toward A2780 ovarian human cell line resistant (R) to cisplatin in experiment 2
|
ChEMBL.
|
11000008
|
IC50 (functional)
|
1.837 uM
|
PUBCHEM_BIOASSAY: Discovery of Small Molecule Probes for H1N1 Influenza NS1A. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504399]
|
ChEMBL.
|
No reference
|
IC50 (binding)
|
= 25 uM
|
Displacement of [125I]-CCL3 from human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs
|
ChEMBL.
|
22957890
|
IC50 (functional)
|
> 100 uM
|
PUBCHEM_BIOASSAY: Dose Response confirmation of uHTS inhibitors of Human Intestinal Alkaline Phosphatase using Mouse Intestinal Alkaline Phosphatase. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2544, AID2574]
|
ChEMBL.
|
No reference
|
Inhibition (functional)
|
= 0 %
|
GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 LDH activity, using an LDH reporter assay. Test compounds present at 2uM
|
ChEMBL.
|
20485427
|
Inhibition (functional)
|
= 2.46 %
|
ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmPfHT that are glucose transport deficient and complemented with the Plasmodium falciparum hexose transporter. Activity is measured by by DNA content using SYBR green in vitro
|
ChEMBL.
|
No reference
|
Inhibition (functional)
|
= 2.49 %
|
ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGT2 that are glucose transport deficient and complemented with the L. Mexicana glucose transporter 2. Activity is measured by by DNA content using SYBR green in vitro
|
ChEMBL.
|
No reference
|
Inhibition (functional)
|
= 3.92 %
|
ST_JUDE_LEISH: Cytotoxicity at 2uM final concentration against transgenic Leishmania Mexicana promastigotes LmGLUT1 that are glucose transport deficient and complemented with the human glucose transporter GLUT1. Activity is measured by DNA content using SYBR green in vitro
|
ChEMBL.
|
No reference
|
Inhibition (functional)
|
= 45 %
|
GSK_TCMDC: Percent inhibition of human HepG2 cell line. Test compounds present at 10uM.
|
ChEMBL.
|
20485427
|
Inhibition (functional)
|
= 98 %
|
GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM
|
ChEMBL.
|
20485427
|
Inhibition (functional)
|
= 99 %
|
GSK_TCMDC: Inhibition of Plasmodium falciparum Dd2 in whole red blood cells, using parasite LDH activity as an index of growth. Test compounds present at 2uM
|
ChEMBL.
|
20485427
|
Inhibition (binding)
|
= 769 %
|
Displacement of [125I]-CCL3 from human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrs relative to basal level
|
ChEMBL.
|
22957890
|
Inhibition frequency index (IFI) (functional)
|
= 5.59
|
Inhibition Frequency Index (IFI)
|
GSK.
|
20485427
|
Percent growth inhibition (functional)
|
= -1 %
|
Percent inhibition of P. falciparum lactate dehydrogenase activity (at 2 uM)
|
GSK.
|
20485427
|
Percent growth inhibition (functional)
|
= 45 %
|
Percent inhibition of HepG2 growth (at 10 uM)
|
GSK.
|
20485427
|
Percent growth inhibition (functional)
|
= 98 %
|
Percent inhibition of P. falciparum 3D7 growth (at 2 uM)
|
GSK.
|
20485427
|
Percent growth inhibition (functional)
|
= 99 %
|
Percent inhibition of P. falciparum Dd2 growth (at 2 uM)
|
GSK.
|
20485427
|
Potency (binding)
|
= 0.1122 um
|
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1). (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
0.5012 uM
|
PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
0.631 uM
|
PubChem BioAssay. qHTS Assay to Identify Small Molecule Activators of BRCA1 Expression. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 0.7943 um
|
PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 1 um
|
PUBCHEM_BIOASSAY: qHTS Assay for Enhancers of SMN2 Splice Variant Expression. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
1.4716 uM
|
PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 1.7783 um
|
PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
1.9953 uM
|
PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
2.0588 uM
|
PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
2.3109 uM
|
PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
2.5119 uM
|
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2312, AID2537, AID2702]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 3.9811 um
|
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
4.1095 uM
|
PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 4.4668 um
|
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Bacillus subtilis Sfp phosphopantetheinyl transferase (PPTase). (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 5.6234 um
|
PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
6.5733 uM
|
PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 7.9245 um
|
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia. (Class of assay: confirmatory) [Related pubchem assays: 2472, 2464 ]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 7.9433 um
|
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of 15-hLO (15-human lipoxygenase). (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 10 um
|
PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
10 uM
|
PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
10 uM
|
PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
11.2202 uM
|
PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
12.5168 uM
|
PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 12.5893 um
|
PUBCHEM_BIOASSAY: qHTS for inhibitors of ROR gamma transcriptional activity. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
12.5893 uM
|
PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
17.7828 uM
|
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 19.9526 um
|
PUBCHEM_BIOASSAY: qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature. (Class of assay: confirmatory) [Related pubchem assays: 902 ]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
19.9526 uM
|
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
20.5962 uM
|
PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
24.9744 uM
|
PubChem BioAssay. qHTS for inhibitors of Vif-A3F interactions: Cherry picks counterscreen. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
26.8545 uM
|
PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 28.1838 um
|
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E). (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 28.1838 um
|
PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
29.0929 uM
|
PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
29.0929 uM
|
PUBCHEM_BIOASSAY: qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493106, AID493143]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
35.4813 uM
|
PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
35.4813 uM
|
PubChem BioAssay. qHTS of alpha-syn Inhibitors. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 39.8107 um
|
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of the ERK Signaling Pathway using a Homogeneous Screening Assay. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Potency (functional)
|
= 50.1187 um
|
PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Giardia lamblia growth inhibition. (Class of assay: confirmatory) [Related pubchem assays: 2451, 2472, 2464 ]
|
ChEMBL.
|
No reference
|
Potency (functional)
|
63.0957 uM
|
PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory)
|
ChEMBL.
|
No reference
|
Ratio (functional)
|
= 2.88
|
Ratio of cytotoxic activity against resistant cell line to that of sensitive cell line
|
ChEMBL.
|
11000008
|
Ratio EC50 (binding)
|
= 8.4
|
Ratio of ZnBip EC50 to compound EC50 for human CCR8 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as IP3 turnover by liquid scintillation counting analysis
|
ChEMBL.
|
22957890
|
XC50 (functional)
|
= 6.05
|
XC50 determination of P. falciparum 3D7 growth
|
GSK.
|
20485427
|
XC50 (functional)
|
= 0.90083 uM
|
GSK_TCMDC: Inhibition of Plasmodium falciparum 3D7 in whole erythrocytes, using parasite LDH activity as an index of growth.
|
ChEMBL.
|
20485427
|