Detailed information for compound 1463275

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 360.293 | Formula: C16H11F3N6O
  • H donors: 1 H acceptors: 5 LogP: 1.33 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1nnc2c(c1N)ccc(c2c1ncccn1)F)N1CC(C1)(F)F
  • InChi: 1S/C16H11F3N6O/c17-9-3-2-8-11(20)13(15(26)25-6-16(18,19)7-25)24-23-12(8)10(9)14-21-4-1-5-22-14/h1-5H,6-7H2,(H2,20,23)
  • InChiKey: WJZLIABKZXQFNX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni tubulin subunit alpha 0.011 0.2098 0.2083
Schistosoma mansoni tubulin subunit beta 0.0468 1 1
Treponema pallidum cell division protein FtsZ 0.011 0.2098 0.5
Trichomonas vaginalis tubulin beta chain, putative 0.0468 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0137 0.0137
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0166 0.3324 0.3324
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.0137 0.0137
Brugia malayi Protein kinase domain containing protein 0.0086 0.1571 0.1555
Echinococcus multilocularis RUN 0.004 0.0539 0.0539
Leishmania major delta tubulin, putative 0.011 0.2098 0.1988
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0779 0.0761
Brugia malayi beta-tubulin, identical 0.0468 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0468 1 1
Loa Loa (eye worm) hypothetical protein 0.0244 0.5052 0.5042
Echinococcus granulosus tubulin delta chain 0.011 0.2098 0.2098
Plasmodium falciparum tubulin delta chain, putative 0.011 0.2098 0.1988
Giardia lamblia Beta tubulin 0.0468 1 1
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0137 0.0137
Trichomonas vaginalis tubulin beta chain, putative 0.0354 0.7482 0.7482
Echinococcus multilocularis ATP binding cassette sub family B 0.002 0.0117 0.0117
Onchocerca volvulus 0.004 0.0539 0.0784
Schistosoma mansoni hypothetical protein 0.0171 0.3446 0.3433
Loa Loa (eye worm) tubulin alpha 2 0.0244 0.5052 0.5042
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.104 0.1023
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0137 0.0137
Schistosoma mansoni apoptosis regulator bax 0.0166 0.3324 0.3312
Echinococcus granulosus Tubulin alpha 1 chain 0.0354 0.7482 0.7482
Leishmania major zeta tubulin, putative 0.011 0.2098 0.1988
Loa Loa (eye worm) multidrug resistance protein 3 0.0021 0.0137 0.0119
Trichomonas vaginalis taga, putative 0.0021 0.0137 0.0137
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0244 0.5052 0.5052
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0137 0.0137
Loa Loa (eye worm) tubulin alpha-2 chain 0.0354 0.7482 0.7477
Echinococcus granulosus tubulin subunit beta 0.0468 1 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0137 0.0137
Echinococcus granulosus ATP binding cassette sub family G 0.0059 0.0979 0.0979
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0137 0.0137
Loa Loa (eye worm) tubulin alpha chain 0.0354 0.7482 0.7477
Echinococcus multilocularis tubulin alpha chain 0.0354 0.7482 0.7482
Leishmania major alpha tubulin 0.0354 0.7482 0.7447
Echinococcus granulosus Tubulin alpha 1 chain 0.0354 0.7482 0.7482
Giardia lamblia Alpha-tubulin 0.0354 0.7482 0.7215
Echinococcus granulosus geminin 0.0171 0.3446 0.3446
Leishmania major beta tubulin 0.0468 1 1
Plasmodium vivax tubulin beta chain, putative 0.0468 1 1
Echinococcus granulosus Tubulin beta 2C chain 0.0468 1 1
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0137 0.0137
Leishmania major ATP-binding cassette protein subfamily G, member 4, putative 0.0059 0.0979 0.0853
Schistosoma mansoni ATP-binding cassette sub-family g2 (white protein) (abcg2) 0.0059 0.0979 0.0962
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0137 0.0137
Leishmania major beta tubulin 0.0468 1 1
Echinococcus granulosus tubulin beta 1 chain 0.0468 1 1
Brugia malayi hypothetical protein 0.004 0.0539 0.0521
Echinococcus granulosus ATP binding cassette sub family G 0.0059 0.0979 0.0979
Echinococcus multilocularis multidrug resistance protein 1 0.0021 0.0137 0.0137
Loa Loa (eye worm) alpha-tubulin 0.0354 0.7482 0.7477
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0166 0.3324 0.3324
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0137 0.0137
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0137 0.0137
Onchocerca volvulus Netrin receptor homolog 0.0086 0.1571 0.2799
Echinococcus multilocularis tubulin gamma 1 chain 0.0254 0.5265 0.5265
Trichomonas vaginalis conserved hypothetical protein 0.011 0.2098 0.2098
Schistosoma mansoni hypothetical protein 0.0166 0.3324 0.3312
Plasmodium vivax tubulin epsilon chain, putative 0.0254 0.5265 0.5199
Echinococcus multilocularis Polycystic kidney disease protein 0.004 0.0539 0.0539
Leishmania major beta tubulin 0.0468 1 1
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0166 0.3324 0.3324
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0086 0.1571 0.1555
Plasmodium vivax delta tubulin, putative 0.011 0.2098 0.1988
Leishmania major beta tubulin 0.0468 1 1
Giardia lamblia Epsilon tubulin 0.011 0.2098 0.126
Giardia lamblia Beta tubulin 0.0468 1 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0253 0.5259 0.5259
Brugia malayi multidrug resistance protein 3 0.0021 0.0137 0.0119
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0253 0.5259 0.525
Echinococcus granulosus RUN 0.004 0.0539 0.0539
Leishmania major beta tubulin 0.0468 1 1
Trypanosoma cruzi beta tubulin, putative 0.0468 1 1
Trypanosoma cruzi alpha tubulin, putative 0.0354 0.7482 0.7209
Plasmodium falciparum alpha tubulin 1 0.0354 0.7482 0.7447
Echinococcus multilocularis GPCR, family 2 0.0016 0.0019 0.0019
Schistosoma mansoni alpha tubulin 0.0354 0.7482 0.7477
Echinococcus granulosus tubulin alpha 0.0254 0.5265 0.5265
Entamoeba histolytica ABC transporter, putative 0.0059 0.0979 0.0853
Echinococcus granulosus netrin receptor unc 5 0.0086 0.1571 0.1571
Leishmania major beta tubulin 0.0468 1 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0779 0.0761
Echinococcus granulosus Polycystic kidney disease protein 0.004 0.0539 0.0539
Leishmania major alpha tubulin 0.0354 0.7482 0.7447
Leishmania major alpha tubulin 0.0354 0.7482 0.7447
Echinococcus granulosus Tubulin beta 2C chain 0.0468 1 1
Trichomonas vaginalis tubulin beta-1 chain, putative 0.011 0.2098 0.2098
Schistosoma mansoni hypothetical protein 0.0034 0.0427 0.0409
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0253 0.5259 1
Trypanosoma brucei beta tubulin 0.0468 1 1
Trypanosoma brucei beta tubulin 0.0468 1 1
Leishmania major beta tubulin 0.0468 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.104 0.1023
Echinococcus multilocularis tubulin alpha 1C chain 0.0354 0.7482 0.7482
Trichomonas vaginalis tubulin epsilon chain, putative 0.0354 0.7482 0.7482
Trichomonas vaginalis tubulin gamma chain, putative 0.011 0.2098 0.2098
Leishmania major beta tubulin 0.0468 1 1
Brugia malayi Tubulin beta chain 0.0144 0.2835 0.2821
Leishmania major beta tubulin 0.0468 1 1
Leishmania major beta tubulin 0.0468 1 1
Brugia malayi Tubulin alpha-2 chain 0.0354 0.7482 0.7477
Echinococcus multilocularis Tubulin beta 2C chain 0.0468 1 1
Echinococcus multilocularis beta tubulin 0.0468 1 1
Leishmania major beta tubulin 0.0468 1 1
Schistosoma mansoni polycystin 1-related 0.004 0.0539 0.0521
Trypanosoma cruzi tubulin gamma chain 0.0254 0.5265 0.4752
Trypanosoma brucei epsilon tubulin 0.0254 0.5265 0.4752
Schistosoma mansoni tumor necrosis factor receptor related 0.0132 0.2573 0.2559
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0211 0.4315 0.4315
Toxoplasma gondii ATP-binding cassette G family transporter ABCG84 0.0059 0.0979 0.0853
Loa Loa (eye worm) hypothetical protein 0.0211 0.4315 0.4304
Echinococcus granulosus tumor necrosis factor receptor superfamily 0.0132 0.2573 0.2573
Trypanosoma brucei alpha tubulin, putative 0.0144 0.2835 0.2057
Echinococcus granulosus tubulin alpha 3 chain 0.0354 0.7482 0.7482
Brugia malayi Immunoglobulin I-set domain containing protein 0.0086 0.1571 0.1555
Brugia malayi tubulin alpha-2 chain 0.0354 0.7482 0.7477
Loa Loa (eye worm) doublecortin family protein 0.004 0.0539 0.0521
Echinococcus multilocularis tubulin epsilon chain 0.0254 0.5265 0.5265
Entamoeba histolytica tubulin gamma chain 0.0254 0.5265 0.5199
Trichomonas vaginalis tubulin, putative 0.0144 0.2835 0.2835
Trichomonas vaginalis abcb9, putative 0.0021 0.0137 0.0137
Trichomonas vaginalis tubulin alpha chain, putative 0.0144 0.2835 0.2835
Leishmania major alpha tubulin 0.0354 0.7482 0.7447
Trypanosoma brucei beta tubulin 0.0254 0.5265 0.4752
Trichomonas vaginalis tubulin epsilon chain, putative 0.0468 1 1
Schistosoma mansoni netrin receptor unc5 0.0086 0.1571 0.1555
Trichomonas vaginalis tubulin alpha chain, putative 0.0144 0.2835 0.2835
Loa Loa (eye worm) tubulin alpha-3 chain 0.0211 0.4315 0.4304
Echinococcus multilocularis tubulin alpha 0.0254 0.5265 0.5265
Loa Loa (eye worm) tubulin alpha 2 0.01 0.1884 0.1869
Echinococcus multilocularis ATP binding cassette sub family G 0.0059 0.0979 0.0979
Leishmania major gamma-tubulin 0.0254 0.5265 0.5199
Entamoeba histolytica tubulin alpha chain, putative 0.0354 0.7482 0.7447
Plasmodium falciparum tubulin epsilon chain, putative 0.0254 0.5265 0.5199
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 0.0021 0.0137 0.0119
Echinococcus granulosus ATP binding cassette sub family G 0.0059 0.0979 0.0979
Leishmania major alpha tubulin 0.0354 0.7482 0.7447
Loa Loa (eye worm) tubulin beta-2A chain 0.0468 1 1
Echinococcus granulosus beta tubulin 0.0468 1 1
Brugia malayi alpha-tubulin 0.0354 0.7482 0.7477
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0137 0.0137
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0137 0.0137
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0137 0.0137
Echinococcus granulosus tubulin alpha 3 chain 0.0354 0.7482 0.7482
Trichomonas vaginalis tubulin gamma chain, putative 0.0468 1 1
Schistosoma mansoni tubulin subunit beta 0.0468 1 1
Echinococcus granulosus tubulin alpha 1C chain 0.0354 0.7482 0.7482
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0253 0.5259 0.5259
Schistosoma mansoni alpha tubulin 0.0354 0.7482 0.7477
Schistosoma mansoni tubulin subunit epsilon 0.0254 0.5265 0.5256
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0137 0.0137
Plasmodium falciparum tubulin gamma chain 0.0254 0.5265 0.5199
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0137 0.0137
Echinococcus granulosus tubulin subunit TubB 0.0354 0.7482 0.7482
Trichomonas vaginalis tubulin beta chain, putative 0.0354 0.7482 0.7482
Schistosoma mansoni tubulin subunit delta 0.011 0.2098 0.2083
Loa Loa (eye worm) tubulin beta-1 chain 0.0468 1 1
Leishmania major alpha tubulin 0.0354 0.7482 0.7447
Trypanosoma brucei zeta tubulin 0.011 0.2098 0.124
Echinococcus granulosus tubulin alpha chain 0.0354 0.7482 0.7482
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.2329 0.2315
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0253 0.5259 0.5259
Loa Loa (eye worm) TAR-binding protein 0.0062 0.104 0.1023
Trichomonas vaginalis tubulin beta chain, putative 0.0144 0.2835 0.2835
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0137 0.0137
Trichomonas vaginalis tubulin epsilon chain, putative 0.0354 0.7482 0.7482
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0137 0.0137
Echinococcus multilocularis Tubulin alpha 1 chain 0.0354 0.7482 0.7482
Echinococcus multilocularis tubulin delta chain 0.011 0.2098 0.2098
Schistosoma mansoni hypothetical protein 0.0166 0.3324 0.3312
Loa Loa (eye worm) hypothetical protein 0.0354 0.7482 0.7477
Schistosoma mansoni multidrug resistance protein 0.0021 0.0137 0.0119
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0253 0.5259 0.4757
Trypanosoma brucei alpha tubulin 0.0354 0.7482 0.7209
Trypanosoma brucei epsilon tubulin 0.0254 0.5265 0.4752
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0137 0.0137
Entamoeba histolytica tubulin alpha-1 chain 0.0354 0.7482 0.7447
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0137 0.0137
Trypanosoma brucei beta tubulin 0.0468 1 1
Echinococcus multilocularis geminin 0.0171 0.3446 0.3446
Echinococcus granulosus tubulin gamma 1 chain 0.0254 0.5265 0.5265
Leishmania major beta tubulin 0.0468 1 1
Brugia malayi N-terminal motif family protein 0.0177 0.3578 0.3566
Echinococcus multilocularis tubulin beta 1 chain 0.0468 1 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0539 0.0521
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0137 0.0137
Trichomonas vaginalis tubulin, putative 0.011 0.2098 0.2098
Trypanosoma brucei zeta tubulin, putative 0.011 0.2098 0.124
Loa Loa (eye worm) tubulin beta chain 0.0468 1 1
Toxoplasma gondii beta tubulin 0.0468 1 1
Schistosoma mansoni hypothetical protein 0.0171 0.3446 0.3433
Schistosoma mansoni hypothetical protein 0.005 0.076 0.0743
Schistosoma mansoni tubulin subunit alpha 0.0354 0.7482 0.7477
Echinococcus granulosus death domain containing protein 0.0086 0.1571 0.1571
Echinococcus multilocularis tubulin subunit TubB 0.0354 0.7482 0.7482
Loa Loa (eye worm) BEN-1 protein 0.0468 1 1
Brugia malayi RNA binding protein 0.0062 0.104 0.1023
Plasmodium vivax multidomain scavenger receptor, putative 0.004 0.0539 0.0407
Loa Loa (eye worm) hypothetical protein 0.0177 0.3578 0.3566
Leishmania major alpha tubulin 0.0354 0.7482 0.7447
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0253 0.5259 0.5193
Trypanosoma cruzi zeta tubulin, putative 0.011 0.2098 0.124
Plasmodium falciparum alpha tubulin 2 0.0354 0.7482 0.7447
Trypanosoma brucei tubulin delta chain 0.011 0.2098 0.124
Trichomonas vaginalis tubulin, putative 0.0144 0.2835 0.2835
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0253 0.5259 0.5259
Schistosoma mansoni tar DNA-binding protein 0.0062 0.104 0.1023
Trichomonas vaginalis tubulin alpha chain, putative 0.0144 0.2835 0.2835
Leishmania major ATP-binding cassette protein subfamily G, member 6, putative 0.0059 0.0979 0.0853
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0021 0.0137 0.0137
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0236 0.4881 0.4881
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0354 0.7482 0.7482
Echinococcus multilocularis netrin receptor unc 5 0.0086 0.1571 0.1571
Echinococcus granulosus Tubulin beta 2C chain 0.0468 1 1
Loa Loa (eye worm) hypothetical protein 0.0166 0.3324 0.3312
Brugia malayi ABC transporter family protein 0.0021 0.0137 0.0119
Trichomonas vaginalis tubulin gamma chain, putative 0.0254 0.5265 0.5265
Echinococcus granulosus tubulin epsilon chain 0.0254 0.5265 0.5265
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0137 0.0137
Echinococcus multilocularis beta tubulin 0.0468 1 1
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0137 0.0137
Schistosoma mansoni ABC transporter 0.005 0.078 0.0763
Echinococcus granulosus tubulin alpha chain 0.0354 0.7482 0.7482
Echinococcus granulosus Tubulin beta 2C chain 0.0468 1 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.011 0.2098 0.1988
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP 0.0021 0.0137 0.0137
Echinococcus multilocularis tubulin alpha chain 0.0354 0.7482 0.7482
Mycobacterium leprae cell division protein FtsZ 0.011 0.2098 0.5
Loa Loa (eye worm) ABC transporter 0.005 0.078 0.0763
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0254 0.5265 0.5199
Onchocerca volvulus 0.0253 0.5259 1
Trypanosoma brucei alpha tubulin 0.0354 0.7482 0.7209
Schistosoma mansoni smdr2 0.0021 0.0137 0.0119
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0779 0.0761
Echinococcus multilocularis hypothetical protein 0.0354 0.7482 0.7482
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0137 0.0137
Schistosoma mansoni tar DNA-binding protein 0.0062 0.104 0.1023
Echinococcus granulosus tubulin alpha 1C chain 0.0354 0.7482 0.7482
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0253 0.5259 0.5259
Schistosoma mansoni rab6-interacting 0.004 0.0539 0.0521
Toxoplasma gondii beta-1 tubulin, putative 0.0468 1 1
Trichomonas vaginalis ATP-binding cassette transporter, putative 0.0021 0.0137 0.0137
Schistosoma mansoni hypothetical protein 0.0086 0.1571 0.1555
Echinococcus multilocularis tubulin alpha chain 0.0354 0.7482 0.7482
Trichomonas vaginalis ABC transporter, half transporter, putative 0.0021 0.0137 0.0137
Plasmodium vivax tubulin gamma chain, putative 0.0254 0.5265 0.5199
Schistosoma mansoni tubulin subunit gamma 0.0254 0.5265 0.5256
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0137 0.0137
Trichomonas vaginalis abcb9, putative 0.0021 0.0137 0.0137
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.104 0.1023
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0539 0.0539
Chlamydia trachomatis ABC transporter ATP binding protein/permease 0.0021 0.0137 0.5
Loa Loa (eye worm) tubulin gamma chain 0.0254 0.5265 0.5256
Echinococcus multilocularis Tubulin beta 2C chain 0.0468 1 1
Trichomonas vaginalis tubulin beta chain, putative 0.0354 0.7482 0.7482
Trichomonas vaginalis tubulin beta chain, putative 0.0354 0.7482 0.7482
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0137 0.0137
Trypanosoma brucei beta tubulin 0.0468 1 1
Schistosoma mansoni tubulin subunit alpha 0.0354 0.7482 0.7477
Brugia malayi Uncoordinated protein 44 0.0086 0.1571 0.1555
Trichomonas vaginalis tubulin epsilon chain, putative 0.0468 1 1
Schistosoma mansoni alpha tubulin 0.0354 0.7482 0.7477
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0144 0.2835 0.2835
Schistosoma mansoni ankyrin 23/unc44 0.0086 0.1571 0.1555
Loa Loa (eye worm) hypothetical protein 0.0086 0.1571 0.1555
Leishmania major alpha tubulin 0.0354 0.7482 0.7447
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0253 0.5259 0.5259
Schistosoma mansoni loxhd1 0.004 0.0539 0.0521
Echinococcus granulosus tar DNA binding protein 0.0062 0.104 0.104
Trichomonas vaginalis abcb9, putative 0.0021 0.0137 0.0137
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0137 0.0137
Echinococcus multilocularis Tubulin alpha 1 chain 0.0354 0.7482 0.7482
Plasmodium vivax ABC transporter G family member 2, putative 0.0059 0.0979 0.0853
Brugia malayi Cell division protein ftsZ 0.011 0.2098 0.2083
Brugia malayi Death domain containing protein 0.0086 0.1571 0.1555
Entamoeba histolytica tubulin family protein 0.0468 1 1
Echinococcus multilocularis TNFR CD27 30 40 95 cysteine rich region 0.0132 0.2573 0.2573
Plasmodium vivax tubulin alpha chain, putative 0.0354 0.7482 0.7447
Echinococcus multilocularis tubulin alpha chain 0.0354 0.7482 0.7482
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0019 0.0019
Brugia malayi Tubulin gamma chain 0.0254 0.5265 0.5256
Mycobacterium tuberculosis Cell division protein FtsZ 0.011 0.2098 0.3828
Entamoeba histolytica tubulin family protein 0.0468 1 1
Mycobacterium tuberculosis Probable conserved transmembrane ATP-binding protein ABC transporter 0.005 0.076 0.1216
Schistosoma mansoni tubulin subunit beta 0.0468 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0468 1 1
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.011 0.2098 0.5
Schistosoma mansoni multidrug resistance protein 0.0021 0.0137 0.0119
Trypanosoma brucei alpha tubulin 0.0354 0.7482 0.7209
Schistosoma mansoni hypothetical protein 0.004 0.0539 0.0521
Echinococcus granulosus tubulin alpha chain 0.0354 0.7482 0.7482
Plasmodium vivax tubulin alpha chain, putative 0.0354 0.7482 0.7447
Schistosoma mansoni tubulin subunit beta 0.0468 1 1
Loa Loa (eye worm) alpha-tubulin 0.0354 0.7482 0.7477
Trichomonas vaginalis tubulin beta chain, putative 0.0354 0.7482 0.7482
Echinococcus granulosus Ankyrin 0.0086 0.1571 0.1571
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0166 0.3324 0.3324
Leishmania major alpha tubulin 0.0354 0.7482 0.7447
Loa Loa (eye worm) tubulin alpha chain 0.0354 0.7482 0.7477
Trypanosoma brucei alpha tubulin 0.0354 0.7482 0.7209
Toxoplasma gondii beta-tubulin, putative 0.0468 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.104 0.1023
Brugia malayi Tubulin alpha chain 0.011 0.2098 0.2083
Trichomonas vaginalis tubulin beta chain, putative 0.0354 0.7482 0.7482
Echinococcus multilocularis tubulin alpha 1C chain 0.0354 0.7482 0.7482
Brugia malayi TAR-binding protein 0.0062 0.104 0.1023
Echinococcus granulosus multidrug resistance protein 1 0.0021 0.0137 0.0137
Echinococcus multilocularis tumor necrosis factor receptor superfamily 0.0132 0.2573 0.2573
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0539 0.0539
Trypanosoma cruzi epsilon tubulin, putative 0.0254 0.5265 0.4752
Toxoplasma gondii alpha tubulin TUBA1 0.0354 0.7482 0.7447
Loa Loa (eye worm) hypothetical protein 0.002 0.0117 0.0098
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) 0.0021 0.0137 0.0137
Echinococcus granulosus tubulin alpha chain 0.0354 0.7482 0.7482
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0253 0.5259 0.5193
Trichomonas vaginalis tubulin alpha chain, putative 0.0254 0.5265 0.5265
Echinococcus multilocularis ATP binding cassette sub family G 0.0059 0.0979 0.0979
Echinococcus granulosus GPCR family 2 0.0016 0.0019 0.0019
Brugia malayi Tubulin beta chain 0.011 0.2098 0.2083
Onchocerca volvulus 0.0144 0.2835 0.5266
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0253 0.5259 1
Trypanosoma brucei tubulin gamma chain 0.0254 0.5265 0.4752
Trypanosoma brucei epsilon tubulin 0.0254 0.5265 0.4752
Echinococcus multilocularis Ankyrin 0.0086 0.1571 0.1571
Trichomonas vaginalis tubulin gamma chain, putative 0.0254 0.5265 0.5265
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0086 0.1571 0.1571
Schistosoma mansoni lipoxygenase 0.0165 0.3312 0.33
Loa Loa (eye worm) hypothetical protein 0.0034 0.0427 0.0409
Loa Loa (eye worm) apoptosis regulator protein 0.0166 0.3324 0.3312
Echinococcus granulosus Tubulin beta 2C chain 0.0468 1 1
Trypanosoma cruzi tubulin delta chain 0.011 0.2098 0.124
Giardia lamblia Delta tubulin 0.011 0.2098 0.126
Leishmania major beta tubulin 0.0468 1 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.011 0.2098 0.1988
Echinococcus granulosus TNFR CD27 30 40 95 cysteine rich region 0.0132 0.2573 0.2573
Trichomonas vaginalis tubulin, putative 0.0468 1 1
Echinococcus multilocularis tubulin alpha chain 0.0354 0.7482 0.7482
Echinococcus granulosus Tubulin alpha 1 chain 0.0354 0.7482 0.7482
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0137 0.0137
Giardia lamblia Beta tubulin 0.0468 1 1
Echinococcus granulosus peroxisome assembly protein 26 0.0354 0.7482 0.7482
Leishmania major beta tubulin 0.0468 1 1
Echinococcus multilocularis tubulin alpha 3 chain 0.0354 0.7482 0.7482
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0236 0.4881 0.4881
Brugia malayi MH2 domain containing protein 0.0121 0.2329 0.2315
Trichomonas vaginalis tubulin epsilon chain, putative 0.011 0.2098 0.2098
Toxoplasma gondii alpha-tubulin I, putative 0.0354 0.7482 0.7447
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0166 0.3324 0.3312
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0253 0.5259 0.525
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0177 0.3578 0.6718
Plasmodium falciparum ABC transporter G family member 2 0.0059 0.0979 0.0853
Loa Loa (eye worm) hypothetical protein 0.004 0.0539 0.0521
Plasmodium falciparum tubulin beta chain 0.0468 1 1
Mycobacterium ulcerans cell division protein FtsZ 0.011 0.2098 0.2614
Schistosoma mansoni lipoxygenase 0.0236 0.4881 0.4871
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0137 0.0137
Giardia lamblia Gamma tubulin 0.0254 0.5265 0.4763
Echinococcus multilocularis tubulin alpha 3 chain 0.0354 0.7482 0.7482
Loa Loa (eye worm) hypothetical protein 0.0021 0.0137 0.0119
Echinococcus granulosus alpha tubulin 0.0354 0.7482 0.7482
Trichomonas vaginalis conserved hypothetical protein 0.011 0.2098 0.2098
Echinococcus granulosus tubulin alpha chain 0.0354 0.7482 0.7482
Echinococcus granulosus beta tubulin 0.0468 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0427 0.0409
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0468 1 1
Echinococcus granulosus tubulin beta 4A class IVa 0.0468 1 1
Echinococcus multilocularis tar DNA binding protein 0.0062 0.104 0.104
Trypanosoma cruzi tubulin delta chain 0.011 0.2098 0.124
Loa Loa (eye worm) beta-tubulin 0.0468 1 1
Brugia malayi Tubulin alpha chain 0.0354 0.7482 0.7477
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0021 0.0137 0.0119
Trichomonas vaginalis multidrug resistance protein 1, 2, putative 0.0021 0.0137 0.0137
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0019 0.0019
Echinococcus multilocularis Tubulin beta 2C chain 0.0468 1 1
Loa Loa (eye worm) tubulin beta chain 0.011 0.2098 0.2083
Echinococcus multilocularis peroxisome assembly protein 26 0.0354 0.7482 0.7482
Echinococcus granulosus 5'partial|ATP binding cassette sub family B 0.002 0.0117 0.0117
Leishmania major beta tubulin 0.0468 1 1
Echinococcus multilocularis ATP binding cassette sub family G 0.0059 0.0979 0.0979
Leishmania major alpha tubulin 0.0354 0.7482 0.7447
Schistosoma mansoni rab6-interacting 0.004 0.0539 0.0521
Leishmania major alpha tubulin 0.0354 0.7482 0.7447
Schistosoma mansoni tubulin subunit beta 0.0468 1 1
Brugia malayi ABC transporter family protein 0.005 0.078 0.0763
Echinococcus multilocularis Tubulin alpha 1 chain 0.0354 0.7482 0.7482
Brugia malayi hypothetical protein 0.004 0.0539 0.0521
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0137 0.0137
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0166 0.3324 0.3312
Trichomonas vaginalis tubulin alpha chain, putative 0.0468 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0019 0.0019
Schistosoma mansoni tubulin subunit beta 0.0468 1 1
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0086 0.1571 0.1555
Schistosoma mansoni hypothetical protein 0.0166 0.3324 0.3312
Trichomonas vaginalis ABC transporter, putative 0.0021 0.0137 0.0137
Onchocerca volvulus 0.004 0.0539 0.0784
Plasmodium falciparum LCCL domain-containing protein 0.004 0.0539 0.0407
Loa Loa (eye worm) RNA binding protein 0.0062 0.104 0.1023
Schistosoma mansoni multidrug resistance protein 0.0021 0.0137 0.0119
Brugia malayi tubulin alpha chain - mouse 0.0354 0.7482 0.7477
Leishmania major epsilon tubulin, putative 0.0254 0.5265 0.5199
Schistosoma mansoni tubulin subunit beta 0.011 0.2098 0.2083
Brugia malayi Doublecortin family protein 0.004 0.0539 0.0521
Loa Loa (eye worm) hypothetical protein 0.005 0.0779 0.0761
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0086 0.1571 0.1571
Echinococcus multilocularis lipoxygenase domain containing protein 0.004 0.0539 0.0539
Loa Loa (eye worm) tubulin beta-4 chain 0.0468 1 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.104 0.1023
Leishmania major beta tubulin 0.0468 1 1
Schistosoma mansoni tubulin subunit alpha 0.0354 0.7482 0.7477
Loa Loa (eye worm) hypothetical protein 0.0086 0.1571 0.1555
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative 0.0021 0.0137 0.0137
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.2329 0.2315
Echinococcus granulosus lipoxygenase domain containing protein 0.004 0.0539 0.0539
Leishmania major beta tubulin 0.0468 1 1
Loa Loa (eye worm) tubulin alpha 2 0.0244 0.5052 0.5042
Brugia malayi Tubulin alpha-2 chain 0.0354 0.7482 0.7477
Trypanosoma cruzi epsilon tubulin, putative 0.0254 0.5265 0.4752
Echinococcus multilocularis tubulin subunit beta 0.0468 1 1
Leishmania major beta tubulin 0.0468 1 1
Trypanosoma cruzi zeta tubulin, putative 0.011 0.2098 0.124
Leishmania major alpha tubulin 0.0354 0.7482 0.7447
Loa Loa (eye worm) BEN-1 protein 0.0468 1 1
Giardia lamblia Alpha-tubulin 0.0354 0.7482 0.7215
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0244 0.5052 0.5042

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) = 7 % Negative allosteric modulation of human alpha2beta3gamma2 GABA receptor expressed in Xenopus laevis oocytes at 1 uM ChEMBL. 20980155
Activity (binding) = 13 % Positive allosteric modulation of human alpha5beta3gamma2 GABA receptor expressed in Xenopus laevis oocytes at 1 uM ChEMBL. 20980155

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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