Detailed information for compound 1467770

Basic information

Technical information
  • TDR Targets ID: 1467770
  • Name: 2-(benzimidazol-1-yl)-N-(ethoxymethyl)-N-(2-e thyl-6-methylphenyl)acetamide
  • MW: 351.442 | Formula: C21H25N3O2
  • H donors: 0 H acceptors: 2 LogP: 4.1 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOCN(c1c(C)cccc1CC)C(=O)Cn1cnc2c1cccc2
  • InChi: 1S/C21H25N3O2/c1-4-17-10-8-9-16(3)21(17)24(15-26-5-2)20(25)13-23-14-22-18-11-6-7-12-19(18)23/h6-12,14H,4-5,13,15H2,1-3H3
  • InChiKey: SAUIKFVDFJVPJX-UHFFFAOYSA-N  

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(benzimidazol-1-yl)-N-(ethoxymethyl)-N-(2-ethyl-6-methyl-phenyl)acetamide
  • 2-(1-benzimidazolyl)-N-(ethoxymethyl)-N-(2-ethyl-6-methylphenyl)acetamide
  • 2-(benzimidazol-1-yl)-N-(ethoxymethyl)-N-(2-ethyl-6-methyl-phenyl)ethanamide
  • ZINC02197656
  • MLS000687533
  • SMR000283560
  • 2-Benzoimidazol-1-yl-N-ethoxymethyl-N-(2-ethyl-6-methyl-phenyl)-acetamide
  • BAS 03162032
  • Oprea1_416982
  • IDI1_010215
  • STOCK3S-45014
  • IFLab1_004460
  • EU-0010103
  • Oprea1_193858

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 539 aa 22.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, point mutation,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.3 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 454 aa 25.3 %
Leishmania braziliensis 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 450 aa 25.6 %
Trypanosoma brucei dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.4 %
Neospora caninum glutathione reductase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 32.7 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 529 aa 31.8 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 462 aa 25.8 %
Leishmania infantum acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.3 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.9 %
Plasmodium berghei dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 26.9 %
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 519 aa 23.7 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.5 %
Onchocerca volvulus Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 57.3 %
Plasmodium falciparum glutathione reductase Thioredoxin reductase 1, cytoplasmic   499 aa 500 aa 32.2 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial Thioredoxin reductase 1, cytoplasmic   499 aa 465 aa 27.3 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 540 aa 23.3 %
Leishmania donovani dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Plasmodium falciparum thioredoxin reductase Thioredoxin reductase 1, cytoplasmic   499 aa 511 aa 45.2 %
Neospora caninum hypothetical protein Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.0 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative,acetoin dehydrogenase e3 component, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.2 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 483 aa 23.0 %
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 490 aa 23.5 %
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.7 %
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative Thioredoxin reductase 1, cytoplasmic   499 aa 460 aa 25.4 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 492 aa 23.2 %
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II Thioredoxin reductase 1, cytoplasmic   499 aa 448 aa 27.2 %
Leishmania donovani acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania braziliensis acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 22.8 %
Trypanosoma congolense dihydrolipoamide dehydrogenase, point mutation Thioredoxin reductase 1, cytoplasmic   499 aa 489 aa 22.5 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin reductase 1, cytoplasmic   499 aa 518 aa 24.9 %
Trypanosoma brucei gambiense dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 491 aa 23.6 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin reductase 1, cytoplasmic   499 aa 464 aa 24.8 %
Leishmania braziliensis dihydrolipoamide dehydrogenase Thioredoxin reductase 1, cytoplasmic   499 aa 488 aa 21.9 %
Leishmania mexicana acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 499 aa 24.4 %
Leishmania infantum dihydrolipoamide dehydrogenase, putative Thioredoxin reductase 1, cytoplasmic   499 aa 466 aa 20.6 %
Leishmania major acetoin dehydrogenase e3 component-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 497 aa 24.1 %
Leishmania mexicana 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein Thioredoxin reductase 1, cytoplasmic   499 aa 452 aa 25.7 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni hypothetical protein 0.0233 0.013 0.1707
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0662 0.0411 0.4565
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0233 0.013 0.1746
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0233 0.013 0.0364
Trypanosoma cruzi target of rapamycin kinase 3 0.1163 0.0738 0.2116
Trichomonas vaginalis PIKK family atypical protein kinase 0.1163 0.0738 0.9909
Toxoplasma gondii FATC domain-containing protein 0.0667 0.0413 0.5605
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0233 0.013 0.1707
Loa Loa (eye worm) hypothetical protein 0.0041 0.0004 0.0057
Loa Loa (eye worm) hypothetical protein 0.0723 0.045 0.6041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0674 0.0418 0.5594
Onchocerca volvulus 0.0233 0.013 0.7866
Leishmania major phosphatidylinositol kinase related protein, putative 0.0249 0.014 0.0379
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0492 0.0299 0.2749
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0111 0.1463
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.1174 0.0745 0.2046
Trypanosoma brucei cytochrome P450, putative 0.0059 0.0016 0.0173
Schistosoma mansoni hypothetical protein 0.0494 0.03 0.3953
Brugia malayi Cytochrome P450 family protein 0.0059 0.0016 0.0211
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0233 0.013 0.1706
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.013 0.0062 0.4688
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0233 0.013 0.1746
Loa Loa (eye worm) hypothetical protein 0.049 0.0298 0.3996
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0145 0.0072 0.544
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0733 0.0457 0.6115
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.1174 0.0745 0.9803
Toxoplasma gondii thioredoxin reductase 0.0057 0.0015 0.0181
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0233 0.013 0.7735
Trypanosoma brucei target of rapamycin kinase 3, putative 0.1163 0.0738 0.9909
Trichomonas vaginalis PIKK family atypical protein kinase 0.1163 0.0738 0.9909
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0233 0.013 0.0128
Brugia malayi Pre-SET motif family protein 0.0037 0.0001 0.0018
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0233 0.013 0.1713
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0305 0.0177 0.0763
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.029 0.0167 0.2212
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.1174 0.0745 0.0745
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.029 0.0167 0.2219
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.029 0.0167 0.2202
Toxoplasma gondii histone lysine methyltransferase SET1 0.0067 0.0021 0.0269
Brugia malayi Cytochrome P450 family protein 0.004 0.0003 0.0042
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0111 0.1463
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0007 0.009
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0472 0.0286 0.0286
Loa Loa (eye worm) hypothetical protein 0.0201 0.0109 0.1461
Trichomonas vaginalis PIKK family atypical protein kinase 0.065 0.0403 0.539
Trichomonas vaginalis PIKK family atypical protein kinase 0.0684 0.0425 0.5685
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0001 0.0000096853
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.029 0.0167 0.2219
Leishmania major cytochrome p450-like protein 0.0059 0.0016 0.0035
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.114 0.0723 0.9705
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0667 0.0413 0.5531
Loa Loa (eye worm) phosphatidylinositol 3 0.0233 0.013 0.1741
Trichomonas vaginalis PIKK family atypical protein kinase 0.1152 0.0731 0.9811
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.1174 0.0745 1
Loa Loa (eye worm) hypothetical protein 0.0233 0.013 0.1741
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0001 0.0018
Trichomonas vaginalis PIKK family atypical protein kinase 0.1153 0.0731 0.9819
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0233 0.013 0.7538
Loa Loa (eye worm) phosphatidylinositol 3 0.0233 0.013 0.1741
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0673 0.0418 0.1193
Loa Loa (eye worm) cytochrome P450 family protein 0.0125 0.0059 0.0792
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0434 0.0261 0.0742
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0118 0.156
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.044 0.0265 0.2204
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0667 0.0413 0.1181
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.1163 0.0738 0.2027
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0312 0.0181 0.2434
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0563 0.0346 0.4623
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0673 0.0418 0.5497
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.029 0.0167 0.0167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0243 0.0136 0.1803
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1197 0.076 0.076
Echinococcus multilocularis Zinc finger, PHD finger 0.029 0.0167 0.0166
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0362 0.0214 0.2819
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0181 0.2407
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0233 0.013 0.7735
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0041 0.0004 0.0059
Trichomonas vaginalis PIKK family atypical protein kinase 0.0671 0.0416 0.5571
Brugia malayi glutathione reductase 0.0057 0.0015 0.0193
Trichomonas vaginalis PIKK family atypical protein kinase 0.114 0.0723 0.9705
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0362 0.0214 0.2845
Trichomonas vaginalis PIKK family atypical protein kinase 0.1153 0.0731 0.9819
Loa Loa (eye worm) thioredoxin reductase 0.0057 0.0015 0.0197
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.1174 0.0745 0.2046
Loa Loa (eye worm) phosphatidylinositol 3 0.1152 0.0731 0.9812
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0181 0.2407
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0472 0.0286 0.3766
Trypanosoma cruzi cytochrome P450, putative 0.0059 0.0016 0.0037
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0075 0.0026 0.0346
Brugia malayi Cytochrome P450 family protein 0.0125 0.0059 0.0776
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.04 0.0239 0.178
Trichomonas vaginalis PIKK family atypical protein kinase 0.114 0.0723 0.9705
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0057 0.0015 0.0907
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1197 0.076 0.2178
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0016 0.0215
Trypanosoma cruzi hypothetical protein, conserved 0.5351 0.3476 1
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0233 0.013 0.1707
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.029 0.0167 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.1161 0.0736 0.9886
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0001 0.0001
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0233 0.013 0.1707
Trichomonas vaginalis set domain proteins, putative 0.0287 0.0165 0.2187
Mycobacterium tuberculosis Probable reductase 0.013 0.0062 0.4688
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.029 0.0167 0.0611
Echinococcus granulosus thioredoxin glutathione reductase 0.0057 0.0015 0.0015
Leishmania major phosphatidylinositol 3-kinase, putative 0.114 0.0723 0.1985
Loa Loa (eye worm) phosphatidylinositol 3 0.1174 0.0745 1
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.029 0.0167 0.0472
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0867 0.0544 0.0544
Trichomonas vaginalis PIKK family atypical protein kinase 0.115 0.073 0.9796
Mycobacterium tuberculosis Putative ferredoxin reductase 0.013 0.0062 0.4688
Loa Loa (eye worm) hypothetical protein 0.0434 0.0261 0.3504
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.029 0.0167 0.2202
Trypanosoma cruzi cytochrome P450, putative 0.0059 0.0016 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.115 0.073 0.9796
Leishmania major trypanothione reductase 0.0057 0.0015 0.0032
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0001 0.0018
Loa Loa (eye worm) hypothetical protein 0.0472 0.0286 0.3842
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0001 0.0018
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0233 0.013 0.1707
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 1.5326 1 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.013 0.0062 0.4688
Plasmodium vivax glutathione reductase, putative 0.0057 0.0015 0.08
Trichomonas vaginalis PIKK family atypical protein kinase 0.115 0.073 0.9795
Trichomonas vaginalis PIKK family atypical protein kinase 0.1161 0.0736 0.9886
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0233 0.013 0.1707
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0362 0.0214 0.2819
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1174 0.0745 0.9803
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0362 0.0214 0.2851
Plasmodium vivax hypothetical protein 0.0233 0.013 0.7735
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0233 0.013 0.013
Schistosoma mansoni voltage-gated potassium channel 0.0045 0.0007 0.009
Schistosoma mansoni cpg binding protein 0.0037 0.0001 0.0017
Loa Loa (eye worm) cytochrome P450 family protein 0.0059 0.0016 0.0215
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.029 0.0167 0.2219
Giardia lamblia GTOR 0.1174 0.0745 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0233 0.013 0.1713
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0667 0.0413 0.5441
Echinococcus multilocularis 0.0233 0.013 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.1174 0.0745 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0667 0.0413 0.5535
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0233 0.013 0.1706
Plasmodium vivax thioredoxin reductase, putative 0.0057 0.0015 0.08
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0111 0.1463
Trichomonas vaginalis conserved hypothetical protein 0.049 0.0298 0.3975
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0181 0.2407
Trichomonas vaginalis PIKK family atypical protein kinase 0.1163 0.0738 0.9909
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0233 0.013 0.0364
Trichomonas vaginalis PIKK family atypical protein kinase 0.0233 0.013 0.1713
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.1174 0.0745 1
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0111 0.1463
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0667 0.0413 0.5441
Trypanosoma cruzi trypanothione reductase, putative 0.0057 0.0015 0.0033
Brugia malayi Cytochrome P450 family protein 0.0059 0.0016 0.0211
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1197 0.076 1
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0233 0.013 0.013
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0472 0.0286 0.0285
Plasmodium falciparum phosphatidylinositol 3-kinase 0.029 0.0167 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0417 0.025 0.3337
Mycobacterium tuberculosis Conserved hypothetical protein 0.0233 0.013 1
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0059 0.0016 1
Schistosoma mansoni cytochrome P450 0.004 0.0003 0.0042
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.1174 0.0745 0.2135
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0673 0.0418 0.1193
Loa Loa (eye worm) phosphatidylinositol 3 0.0233 0.013 0.1741
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.065 0.0403 0.0401
Loa Loa (eye worm) phosphatidylinositol 3 0.0129 0.0062 0.083
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0111 0.1463
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.1174 0.0745 0.0744
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1152 0.0731 0.2007
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.029 0.0167 0.0166
Trichomonas vaginalis PIKK family atypical protein kinase 0.1161 0.0736 0.9886
Trichomonas vaginalis PIKK family atypical protein kinase 0.115 0.073 0.9796
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0362 0.0214 0.2851
Entamoeba histolytica hypothetical protein 0.0667 0.0413 0.4612
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0252 0.0142 0.1909
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0181 0.2407
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.1174 0.0745 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.065 0.0403 0.5299
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0181 0.2407
Trichomonas vaginalis PIKK family atypical protein kinase 0.1174 0.0745 1
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0129 0.0062 0.0169
Schistosoma mansoni cpg binding protein 0.0037 0.0001 0.0017
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0867 0.0544 0.0543
Echinococcus granulosus cpg binding protein 0.0037 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0037 0.0001 0.0019
Brugia malayi Pre-SET motif family protein 0.0252 0.0142 0.1871
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0145 0.0072 0.544
Trichomonas vaginalis PIKK family atypical protein kinase 0.115 0.073 0.9795
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0249 0.014 0.0395
Loa Loa (eye worm) CYP4Cod1 0.0059 0.0016 0.0215
Leishmania major phosphatidylinositol 3-kinase, putative 0.029 0.0167 0.0453
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0867 0.0544 0.7161
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0362 0.0214 0.1374
Loa Loa (eye worm) glutathione reductase 0.0057 0.0015 0.0197
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.029 0.0167 0.0453
Leishmania major hypothetical protein, conserved 0.5584 0.3629 1
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0004 0.0056
Loa Loa (eye worm) phosphatidylinositol 3 0.0795 0.0497 0.6675
Loa Loa (eye worm) phosphatidylinositol kinase 0.0233 0.013 0.1741
Leishmania major phosphatidylinositol kinase, putative 0.0233 0.013 0.0349
Trichomonas vaginalis PIKK family atypical protein kinase 0.0671 0.0416 0.5571
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0233 0.013 0.1707
Onchocerca volvulus 0.0287 0.0165 1
Echinococcus granulosus cytochrome P450 2K1 0.004 0.0003 0.0003
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1197 0.076 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0041 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.065 0.0403 0.5406
Echinococcus multilocularis 0.004 0.0003 0.0002
Plasmodium vivax hypothetical protein, conserved 0.0233 0.013 0.7735
Echinococcus multilocularis dnaJ subfamily B 0.0494 0.03 0.0299
Leishmania major phosphatidylinositol 4-kinase, putative 0.0233 0.013 0.0349
Trichomonas vaginalis glucosylceramidase, putative 0.0216 0.0118 0.156
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0233 0.013 0.013
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.029 0.0167 0.2246
Schistosoma mansoni hypothetical protein 0.0041 0.0004 0.0056
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0673 0.0418 0.4681
Trichomonas vaginalis PIKK family atypical protein kinase 0.1163 0.0738 0.9909
Echinococcus granulosus serine:threonine protein kinase SMG1 0.065 0.0403 0.0403
Trichomonas vaginalis PIKK family atypical protein kinase 0.1161 0.0736 0.9886
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0233 0.013 0.0364
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.029 0.0167 0.0611
Echinococcus granulosus serine protein kinase ATM 0.0667 0.0413 0.0413
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.1174 0.0745 1
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0312 0.0181 0.2386
Trichomonas vaginalis PIKK family atypical protein kinase 0.114 0.0723 0.9705
Trichomonas vaginalis glucosylceramidase, putative 0.0312 0.0181 0.2407
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1197 0.076 0.2178
Schistosoma mansoni phosphatidylinositol 4-kinase 0.029 0.0167 0.2202
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.029 0.0167 0.2257
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0233 0.013 0.0128
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0111 0.1463
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.1174 0.0745 0.2135
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.029 0.0167 0.0472
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0254 0.0143 0.1887
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.049 0.0298 0.0298
Schistosoma mansoni hypothetical protein 0.004 0.0003 0.0042
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0673 0.0418 0.5592
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0041 0.0004 0.0057
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0001 0.0018
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0362 0.0214 0.0607
Trichomonas vaginalis PIKK family atypical protein kinase 0.1161 0.0736 0.9886
Loa Loa (eye worm) cytochrome P450 0.004 0.0003 0.0043
Trichomonas vaginalis PIKK family atypical protein kinase 0.0746 0.0465 0.6232
Trichomonas vaginalis glucosylceramidase, putative 0.0205 0.0111 0.1463
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0041 0.0004 0.0003
Entamoeba histolytica protein kinase rad3, putative 0.065 0.0403 0.4437
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0602 0.0371 0.3918
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0723 0.045 0.6103
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0017 0.0224
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.049 0.0298 0.0296
Toxoplasma gondii cytochrome p450 superfamily protein 0.004 0.0003 0.0024
Leishmania major hypothetical protein, unknown function 0.0233 0.013 0.0349
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0673 0.0418 0.5592
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0145 0.0072 0.544
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1197 0.076 0.0759
Trichomonas vaginalis PIKK family atypical protein kinase 0.0671 0.0416 0.5571
Loa Loa (eye worm) phosphatidylinositol 3 0.0233 0.013 0.1741
Trichomonas vaginalis PIKK family atypical protein kinase 0.115 0.073 0.9795
Trichomonas vaginalis PIKK family atypical protein kinase 0.0233 0.013 0.1713
Brugia malayi cytochrome P450 0.004 0.0003 0.0042
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0001 0.0000096853
Schistosoma mansoni fkbp-rapamycin associated protein 0.065 0.0403 0.5299
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.029 0.0167 0.2257
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0233 0.013 0.7538
Trichomonas vaginalis conserved hypothetical protein 0.0417 0.025 0.3337
Echinococcus multilocularis thioredoxin glutathione reductase 0.0057 0.0015 0.0013
Loa Loa (eye worm) hypothetical protein 0.006 0.0017 0.0224
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.013 0.0062 0.4688
Trichomonas vaginalis conserved hypothetical protein 0.0723 0.045 0.6028
Trypanosoma brucei trypanothione reductase 0.0057 0.0015 0.0155
Trichomonas vaginalis PIKK family atypical protein kinase 0.114 0.0723 0.9705
Trichomonas vaginalis PIKK family atypical protein kinase 0.115 0.073 0.9796
Mycobacterium tuberculosis Probable oxidoreductase 0.0145 0.0072 0.544
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0673 0.0418 0.5592
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0017 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.1161 0.0736 0.9886
Mycobacterium leprae conserved hypothetical protein 0.0233 0.013 1
Onchocerca volvulus Glucosylceramidase homolog 0.0205 0.0111 0.674
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0362 0.0214 0.1374
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0193 0.0104 0.1366
Brugia malayi FAT domain containing protein 0.049 0.0298 0.3917
Entamoeba histolytica hypothetical protein 0.0602 0.0371 0.3918
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0233 0.013 0.1746
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1152 0.0731 0.9811
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.029 0.0167 0.0167
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.065 0.0403 0.115
Toxoplasma gondii target of rapamycin (TOR), putative 0.1161 0.0736 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0662 0.0411 0.5496
Schistosoma mansoni hypothetical protein 0.049 0.0298 0.3917
Onchocerca volvulus 0.0037 0.0001 0.0084
Onchocerca volvulus 0.0233 0.013 0.7866
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0233 0.013 0.7735
Mycobacterium tuberculosis Probable dehydrogenase 0.013 0.0062 0.4688
Brugia malayi Thioredoxin reductase 0.0057 0.0015 0.0193
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0017 0.022
Echinococcus granulosus dnaJ subfamily B 0.0494 0.03 0.03
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0362 0.0214 0.2851
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0563 0.0346 0.4623
Trichomonas vaginalis PIKK family atypical protein kinase 0.1161 0.0736 0.9886
Echinococcus multilocularis serine protein kinase ATM 0.0667 0.0413 0.0412
Trichomonas vaginalis PIKK family atypical protein kinase 0.1174 0.0745 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.013 0.0062 0.4688
Loa Loa (eye worm) hypothetical protein 0.0036 0.0001 0.0011
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0233 0.013 0.0364
Trichomonas vaginalis PIKK family atypical protein kinase 0.1163 0.0738 0.9909

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 1.2589 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] ChEMBL. No reference
Potency (functional) 4.4668 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS Assay for Inhibitors of the HIV-1 protein Vpr. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 37.6505 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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