Detailed information for compound 1486280

Basic information

Technical information
  • TDR Targets ID: 1486280
  • Name: N-[5-(diethylsulfamoyl)-2-morpholin-4-ylpheny l]-2-(4-fluorophenoxy)propanamide
  • MW: 479.565 | Formula: C23H30FN3O5S
  • H donors: 1 H acceptors: 3 LogP: 2.93 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(S(=O)(=O)c1ccc(c(c1)NC(=O)C(Oc1ccc(cc1)F)C)N1CCOCC1)CC
  • InChi: 1S/C23H30FN3O5S/c1-4-27(5-2)33(29,30)20-10-11-22(26-12-14-31-15-13-26)21(16-20)25-23(28)17(3)32-19-8-6-18(24)7-9-19/h6-11,16-17H,4-5,12-15H2,1-3H3,(H,25,28)
  • InChiKey: IWBHQLXNGDHZEN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-[5-(diethylsulfamoyl)-2-morpholino-phenyl]-2-(4-fluorophenoxy)propanamide
  • N-[5-(diethylsulfamoyl)-2-morpholinophenyl]-2-(4-fluorophenoxy)propanamide
  • N-[5-(diethylsulfamoyl)-2-morpholino-phenyl]-2-(4-fluorophenoxy)propionamide
  • N-[5-(diethylsulfamoyl)-2-morpholin-4-yl-phenyl]-2-(4-fluorophenoxy)propanamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0043 0.0153
Brugia malayi hypothetical protein 0.0032 0.0115 0.0423
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0002 0.0008
Onchocerca volvulus 0.002 0.0043 0.0153
Plasmodium vivax aldehyde reductase, putative 0.0127 0.071 0.2388
Schistosoma mansoni malate dehydrogenase 0.0048 0.0217 0.044
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0043 0.0083
Mycobacterium tuberculosis Conserved protein 0.0037 0.0145 0.0537
Leishmania major malate dehydrogenase 0.002 0.0042 0.0151
Echinococcus granulosus matrix metallopeptidase 7 M10 family 0.0586 0.3578 0.7319
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0011 0.0009
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0156 0.052
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0174 0.0172
Echinococcus multilocularis geminin 0.0173 0.0994 0.0993
Plasmodium vivax FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0134 0.0445
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0011 0.0035
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0145 0.0537
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0301 0.0611
Plasmodium falciparum glutathione reductase 0.0039 0.0156 0.052
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0048 0.0217 0.0816
Schistosoma mansoni L-lactate dehydrogenase 0.002 0.0042 0.0082
Loa Loa (eye worm) hypothetical protein 0.0035 0.0136 0.0503
Echinococcus multilocularis tissue type plasminogen activator 0.0023 0.0061 0.0059
Loa Loa (eye worm) hypothetical protein 0.0056 0.0264 0.0986
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.016 0.0323
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0014 0.0002 0.0007
Toxoplasma gondii aldo/keto reductase family oxidoreductase 0.0127 0.071 0.2388
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.0526 0.1973
Trichomonas vaginalis malate dehydrogenase, putative 0.0048 0.0217 0.0816
Loa Loa (eye worm) beta-lactamase 0.0037 0.0145 0.0537
Trypanosoma cruzi mitochondrial malate dehydrogenase, putative 0.002 0.0042 0.0151
Loa Loa (eye worm) oxidoreductase 0.0439 0.2659 1
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0156 0.0581
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0043 0.0153
Brugia malayi PAN domain containing protein 0.0015 0.001 0.0029
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0043 0.0153
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0048 0.0217 0.0215
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0011 0.0031
Brugia malayi CXXC zinc finger family protein 0.0056 0.0265 0.0988
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0043 0.0153
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0474 0.288 0.2878
Loa Loa (eye worm) matrixin family protein 0.0357 0.2149 0.8081
Brugia malayi ecdysteroid receptor 0.002 0.0043 0.0153
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0084 0.0439 0.0895
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0061 0.0223
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0043 0.0083
Brugia malayi Matrixin family protein 0.0161 0.0923 0.3465
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0043 0.0153
Brugia malayi PHD-finger family protein 0.003 0.0101 0.0373
Loa Loa (eye worm) hypothetical protein 0.0084 0.0439 0.1645
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0224 0.0835
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0056 0.0263 0.0983
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0011 0.0035
Trichomonas vaginalis aldo-keto reductase, putative 0.0439 0.2659 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0124 0.0458
Entamoeba histolytica aldose reductase, putative 0.0439 0.2659 1
Echinococcus multilocularis FAD linked sulfhydryl oxidase ALR 0.0035 0.0134 0.0132
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0043 0.0083
Schistosoma mansoni matrix metallopeptidase-7 (M10 family) 0.0161 0.0923 0.1885
Brugia malayi PAN domain containing protein 0.0015 0.001 0.0029
Loa Loa (eye worm) malate dehydrogenase 0.002 0.0042 0.0151
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0439 0.2659 0.2658
Schistosoma mansoni hypothetical protein 0.0056 0.0263 0.0535
Plasmodium falciparum aldehyde reductase, putative 0.0127 0.071 0.2388
Schistosoma mansoni ADAMTS14 peptidase (M12 family) 0.0024 0.0065 0.0129
Echinococcus granulosus lactate dehydrogenase a 0.002 0.0042 0.0082
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0224 0.0748
Trichomonas vaginalis mannosyltransferase 1, putative 0.0068 0.0338 0.1272
Echinococcus granulosus aldo keto reductase 0.0439 0.2659 0.5439
Onchocerca volvulus 0.0015 0.001 0.0029
Mycobacterium tuberculosis Conserved protein 0.0037 0.0145 0.0537
Brugia malayi PAN domain containing protein 0.0015 0.001 0.0029
Echinococcus multilocularis adam 0.0051 0.0232 0.023
Mycobacterium leprae Possible oxidoreductase 0.0127 0.071 0.2394
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.002 0.0042 0.0151
Loa Loa (eye worm) hepatopoietin HPO2 0.0035 0.0134 0.0496
Plasmodium vivax lactate dehydrogenase 0.002 0.0042 0.0135
Brugia malayi Matrixin family protein 0.0161 0.0923 0.3465
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0101 0.0373
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.021 0.0784
Trichomonas vaginalis aldo-keto reductase, putative 0.0439 0.2659 1
Toxoplasma gondii aldose reductase, putative 0.0439 0.2659 0.8962
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0224 0.0748
Schistosoma mansoni potassium channel beta 0.0127 0.071 0.145
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0149 0.03
Toxoplasma gondii 1,3(4)-beta-glucanase 0.0015 0.001 0.0026
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0101 0.0203
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0145 0.0544
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0145 0.0537
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0011 0.0009
Schistosoma mansoni malate dehydrogenase 0.0048 0.0217 0.044
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0301 0.0611
Mycobacterium tuberculosis Probable malate dehydrogenase Mdh 0.0048 0.0217 0.0808
Trypanosoma brucei prostaglandin f synthase 0.0439 0.2659 1
Brugia malayi MIR domain containing protein 0.0025 0.007 0.0255
Chlamydia trachomatis malate dehydrogenase 0.0048 0.0217 0.053
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0043 0.0041
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0056 0.0263 0.0535
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0439 0.2659 0.5439
Echinococcus multilocularis peregrin 0.003 0.0101 0.0099
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0047 0.021 0.0709
Brugia malayi PAN domain containing protein 0.0015 0.001 0.0029
Toxoplasma gondii hypothetical protein 0.0015 0.001 0.0026
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0439 0.2659 0.2658
Loa Loa (eye worm) oxidoreductase 0.0439 0.2659 1
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0439 0.2659 1
Schistosoma mansoni hypothetical protein 0.0228 0.1344 0.2746
Onchocerca volvulus 0.0037 0.0145 0.0537
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0043 0.0153
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0255
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0224 0.0835
Mycobacterium ulcerans hydrolase 0.0196 0.1142 0.385
Onchocerca volvulus 0.0287 0.1711 0.6431
Brugia malayi RNA binding protein 0.0062 0.0301 0.1123
Loa Loa (eye worm) oxidoreductase 0.0439 0.2659 1
Echinococcus multilocularis lactate dehydrogenase a 0.002 0.0042 0.004
Loa Loa (eye worm) oxidoreductase 0.0439 0.2659 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0145 0.0537
Echinococcus granulosus adam 0.0051 0.0232 0.0471
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0475 0.0968
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0101 0.0334
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0088 0.0465 0.1742
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0134 0.0445
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0047 0.021 0.0709
Schistosoma mansoni apoptosis regulator bax 0.0056 0.0263 0.0535
Trichomonas vaginalis aldo-keto reductase, putative 0.0127 0.071 0.2671
Onchocerca volvulus 0.0025 0.007 0.0255
Mycobacterium ulcerans hypothetical protein 0.0037 0.0145 0.0488
Toxoplasma gondii thioredoxin reductase 0.0039 0.0156 0.052
Trypanosoma cruzi ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0134 0.0496
Schistosoma mansoni cpg binding protein 0.0056 0.0265 0.0537
Plasmodium falciparum FAD-linked sulfhydryl oxidase ERV1, putative 0.0035 0.0134 0.0445
Trypanosoma cruzi malate dehydrogenase, putative 0.002 0.0042 0.0151
Brugia malayi metalloprotease 0.0024 0.0065 0.0237
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0043 0.0083
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0011 0.0008
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0145 0.0537
Trichomonas vaginalis malate dehydrogenase, putative 0.0048 0.0217 0.0816
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0149 0.03
Echinococcus granulosus L aminoadipate semialdehyde 0.0084 0.0439 0.0895
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.021 0.0784
Echinococcus granulosus cpg binding protein 0.0059 0.0285 0.0578
Schistosoma mansoni coup transcription factor 0.002 0.0043 0.0083
Trichomonas vaginalis malate dehydrogenase, putative 0.0048 0.0217 0.0816
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0153
Trichomonas vaginalis aldo/keto reductase, putative 0.0439 0.2659 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0035 0.0136 0.0458
Trichomonas vaginalis aldo-keto reductase, putative 0.0127 0.071 0.2671
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0011 0.0035
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0014 0.0002 0.0007
Trichomonas vaginalis aldo-keto reductase, putative 0.0127 0.071 0.2671
Loa Loa (eye worm) MIR domain-containing protein 0.0025 0.007 0.0255
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0029
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0475 0.0473
Trichomonas vaginalis set domain proteins, putative 0.0287 0.1711 0.6434
Brugia malayi hypothetical protein 0.0051 0.0232 0.0866
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0145 0.0488
Trypanosoma brucei RNA helicase, putative 0.0111 0.0606 0.2274
Plasmodium falciparum thioredoxin reductase 0.0039 0.0156 0.052
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0043 0.0153
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0043 0.0041
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0047 0.021 0.0784
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0043 0.0041
Mycobacterium tuberculosis Probable dehydrogenase 0.0088 0.0465 0.1742
Leishmania major prostaglandin f2-alpha synthase/D-arabinose dehydrogenase 0.0439 0.2659 1
Brugia malayi AMP-binding enzyme family protein 0.0047 0.021 0.0784
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0002 0.0007
Trypanosoma brucei ERV/ALR sulfhydryl oxidase domain-containing protein 0.0035 0.0134 0.0496
Toxoplasma gondii PAN domain-containing protein 0.0015 0.001 0.0026
Mycobacterium tuberculosis Probable peptidoglycan hydrolase 0.0196 0.1142 0.4291
Brugia malayi isocitrate dehydrogenase 0.0015 0.0011 0.0035
Mycobacterium ulcerans lipase LipD 0.0037 0.0145 0.0488
Toxoplasma gondii aldo-keto reductase 0.0127 0.071 0.2388
Echinococcus granulosus lactate dehydrogenase protein 0.002 0.0042 0.0082
Plasmodium vivax acyl-CoA synthetase, putative 0.0035 0.0136 0.0451
Giardia lamblia Malate dehydrogenase 0.0048 0.0217 0.0452
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0043 0.0153
Mycobacterium ulcerans hypothetical protein 0.0127 0.071 0.2394
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0043 0.0153
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0439 0.2659 1
Brugia malayi PAN domain containing protein 0.0015 0.001 0.0029
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0043 0.0153
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0145 0.0537
Echinococcus granulosus L lactate dehydrogenase B chain 0.002 0.0042 0.0082
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.016 0.0595
Toxoplasma gondii microneme protein, putative 0.0015 0.001 0.0026
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0002 0.0007
Loa Loa (eye worm) hypothetical protein 0.0037 0.0145 0.0537
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.021 0.0784
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0145 0.0544
Loa Loa (eye worm) hypothetical protein 0.0035 0.0136 0.0503
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0043 0.0153
Brugia malayi PAN domain containing protein 0.0015 0.001 0.0029
Leishmania major prostaglandin f synthase, putative 0.0439 0.2659 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0063 0.0205
Brugia malayi angiogenesis inhibito 0.0054 0.0254 0.0949
Schistosoma mansoni hypothetical protein 0.0173 0.0994 0.2031
Loa Loa (eye worm) matrixin family protein 0.039 0.2351 0.8839
Brugia malayi Matrixin family protein 0.0161 0.0923 0.3465
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0063 0.0205
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0011 0.0017
Onchocerca volvulus 0.0018 0.0026 0.009
Loa Loa (eye worm) apoptosis regulator protein 0.0056 0.0263 0.0983
Echinococcus multilocularis cpg binding protein 0.0059 0.0285 0.0282
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0088 0.0465 0.1742
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0043 0.0153
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0338 0.1272
Brugia malayi glutamate-cysteine ligase modifier subunit 0.0127 0.071 0.2665
Schistosoma mansoni L-lactate dehydrogenase 0.002 0.0042 0.0082
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0439 0.2659 0.5439
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0475 0.0968
Onchocerca volvulus 0.0037 0.0149 0.0551
Brugia malayi Hemopexin family protein 0.0228 0.1344 0.5049
Leishmania major malate dehydrogenase, putative 0.002 0.0042 0.0151
Brugia malayi ADAM-TS Spacer 1 family protein 0.0177 0.102 0.383
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0145 0.0537
Mycobacterium ulcerans acetyl-CoA synthetase 0.0014 0.0002 0.0007
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0043 0.0083
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0043 0.0153
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0043 0.0041
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0338 0.1272
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0174 0.0352
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0043 0.0083
Schistosoma mansoni aldo-keto reductase 0.0439 0.2659 0.5439
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0032 0.0112
Trypanosoma cruzi aldo/keto reductase, putative 0.0439 0.2659 1
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0014 0.0002 0.0007
Onchocerca volvulus 0.0015 0.001 0.0029
Loa Loa (eye worm) hypothetical protein 0.0049 0.0224 0.0835
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0035 0.0136 0.0503
Brugia malayi Matrixin family protein 0.0161 0.0923 0.3465
Trichomonas vaginalis malate dehydrogenase, putative 0.0048 0.0217 0.0816
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0063 0.007
Brugia malayi Reprolysin 0.0024 0.0065 0.0237
Leishmania major mitochondrial malate dehydrogenase 0.002 0.0042 0.0151
Brugia malayi glutathione reductase 0.0039 0.0156 0.0581
Echinococcus multilocularis ryanodine receptor 44f 0.0025 0.007 0.0068
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0475 0.0968
Brugia malayi AMP-binding enzyme family protein 0.0047 0.021 0.0784
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0153
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0043 0.0083
Onchocerca volvulus Matrix metalloproteinase homolog 0.0357 0.2149 0.8081
Mycobacterium ulcerans malate dehydrogenase 0.0048 0.0217 0.0731
Loa Loa (eye worm) hypothetical protein 0.0027 0.0082 0.0302
Echinococcus granulosus aldo keto reductase 0.0439 0.2659 0.5439
Loa Loa (eye worm) hypothetical protein 0.0161 0.0923 0.3465
Loa Loa (eye worm) CXXC zinc finger family protein 0.0056 0.0265 0.0988
Onchocerca volvulus 0.0439 0.2659 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0002 0.0007
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0299 0.1117
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.021 0.0709
Schistosoma mansoni hypothetical protein 0.0056 0.0263 0.0535
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0074 0.0377 0.0767
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0153
Onchocerca volvulus 0.0015 0.001 0.0029
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0089 0.0475 0.0968
Loa Loa (eye worm) hypothetical protein 0.0035 0.0136 0.0503
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0037 0.0149 0.03
Echinococcus granulosus stromal cell derived factor 2 0.0025 0.007 0.0139
Brugia malayi NADH-dependent xylose reductase 0.0127 0.071 0.2665
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0474 0.288 0.589
Loa Loa (eye worm) hypothetical protein 0.0023 0.0061 0.0223
Schistosoma mansoni mixed-lineage leukemia protein mll 0.012 0.0664 0.1355
Leishmania major malate dehydrogenase, putative 0.002 0.0042 0.0151
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0014 0.0002 0.0007
Brugia malayi Ryanodine Receptor TM 4-6 family protein 0.0025 0.007 0.0255
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0301 0.1123
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0255
Loa Loa (eye worm) angiogenesis inhibito 0.0027 0.0087 0.0321
Toxoplasma gondii malate dehydrogenase MDH 0.002 0.0042 0.0135
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0145 0.0292
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.0524 0.1067
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.0526 0.1973
Onchocerca volvulus 0.0015 0.001 0.0029
Mycobacterium ulcerans hypothetical protein 0.0047 0.021 0.0709
Brugia malayi nuclear receptor NHR-88 0.002 0.0043 0.0153
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0145 0.0537
Loa Loa (eye worm) hypothetical protein 0.0037 0.0149 0.0551
Loa Loa (eye worm) metalloprotease 0.0024 0.0065 0.0237
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0474 0.288 0.589
Brugia malayi Bromodomain containing protein 0.003 0.0101 0.0373
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0037 0.0149 0.0146
Echinococcus granulosus lactate dehydrogenase a 0.002 0.0042 0.0082
Loa Loa (eye worm) hypothetical protein 0.0024 0.0065 0.0237
Loa Loa (eye worm) hypothetical protein 0.0035 0.0136 0.0503
Mycobacterium tuberculosis Probable reductase 0.0088 0.0465 0.1742
Mycobacterium tuberculosis Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras 0.0117 0.065 0.2436
Loa Loa (eye worm) oxidoreductase 0.0439 0.2659 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0015 0.0011 0.0031
Plasmodium vivax SET domain protein, putative 0.0037 0.0149 0.0494
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0029
Onchocerca volvulus 0.0015 0.001 0.0029
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0145 0.0544
Echinococcus granulosus histone lysine methyltransferase setb 0.0037 0.0149 0.03
Brugia malayi lactate dehydrogenase. 0.002 0.0042 0.0151
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0439 0.2659 0.2658
Echinococcus granulosus tar DNA binding protein 0.0062 0.0301 0.0611
Toxoplasma gondii lactate dehydrogenase LDH1 0.002 0.0042 0.0135
Entamoeba histolytica acyl-CoA synthetase, putative 0.0047 0.021 0.0784
Echinococcus multilocularis lactate dehydrogenase a 0.002 0.0042 0.004
Schistosoma mansoni microtubule-associated protein tau 0.067 0.4104 0.8396
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.016 0.0323
Onchocerca volvulus 0.0015 0.001 0.0029
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.001 0.0029
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0043 0.0153
Trichomonas vaginalis malate dehydrogenase, putative 0.002 0.0042 0.0159
Entamoeba histolytica malate dehydrogenase,cytoplasmic, putative 0.0048 0.0217 0.0808
Loa Loa (eye worm) glutamate-cysteine ligase modifier subunit 0.0127 0.071 0.2665
Echinococcus multilocularis L lactate dehydrogenase B chain 0.002 0.0042 0.004
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0439 0.2659 0.5439
Mycobacterium leprae PROBABLE MALATE DEHYDROGENASE MDH 0.0048 0.0217 0.0731
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0063 0.0205
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0029
Toxoplasma gondii PAN domain-containing protein 0.0015 0.001 0.0026
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0043 0.0153
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0088 0.0465 0.1742
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0089 0.0475 0.1779
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0054 0.0106
Loa Loa (eye worm) hypothetical protein 0.0035 0.0136 0.0503
Loa Loa (eye worm) isocitrate dehydrogenase 0.0015 0.0011 0.0035
Schistosoma mansoni hypothetical protein 0.0173 0.0994 0.2031
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0063 0.0229
Plasmodium vivax lactate/malate dehydrogenase, putative 0.002 0.0042 0.0135
Toxoplasma gondii subtilisin SUB12 0.0015 0.001 0.0026
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0015 0.0011 0.0031
Trichomonas vaginalis aldo-keto reductase, putative 0.0439 0.2659 1
Trypanosoma brucei aldo/keto reductase, putative 0.0127 0.071 0.2665
Toxoplasma gondii hypothetical protein 0.0015 0.001 0.0026
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0089 0.0475 0.1779
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0439 0.2659 0.5439
Toxoplasma gondii microneme protein MIC17C 0.0015 0.001 0.0026
Schistosoma mansoni pol-related 0.0439 0.2659 0.5439
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0037 0.0149 0.03
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0029
Plasmodium falciparum L-lactate dehydrogenase 0.002 0.0042 0.0135
Echinococcus granulosus aldehyde reductase 0.0312 0.1865 0.3813
Mycobacterium tuberculosis Probable oxidoreductase 0.0439 0.2659 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0011 0.0008
Loa Loa (eye worm) matrix metalloproteinase 0.0161 0.0923 0.3465
Echinococcus multilocularis lactate dehydrogenase protein 0.002 0.0042 0.004
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0024 0.0063 0.0229
Trichomonas vaginalis malate dehydrogenase, putative 0.0048 0.0217 0.0816
Trichomonas vaginalis malate dehydrogenase, putative 0.0048 0.0217 0.0816
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0301 0.1123
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0439 0.2659 0.5439
Trypanosoma brucei aldo-keto reductase, putative 0.0439 0.2659 1
Trypanosoma brucei cytosolic malate dehydrogenase 0.0048 0.0217 0.0808
Brugia malayi hypothetical protein 0.0049 0.0224 0.0835
Trichomonas vaginalis aldo/keto reductase, putative 0.0439 0.2659 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0439 0.2659 1
Echinococcus granulosus dnaJ subfamily B 0.0795 0.4887 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0084 0.0439 0.0437
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0014 0.0002 0.0007
Leishmania major cytosolic malate dehydrogenase 0.0048 0.0217 0.0808
Leishmania major glycosomal malate dehydrogenase 0.002 0.0042 0.0151
Schistosoma mansoni malate dehydrogenase 0.002 0.0042 0.0082
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0043 0.0083
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0024 0.0065 0.0129
Loa Loa (eye worm) hypothetical protein 0.003 0.0101 0.0373
Brugia malayi cation channel family protein 0.0025 0.007 0.0255
Plasmodium falciparum malate dehydrogenase 0.002 0.0042 0.0135
Mycobacterium ulcerans oxidoreductase 0.0439 0.2659 0.8962
Leishmania major hypothetical protein, conserved 0.0035 0.0134 0.0496
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0439 0.2659 0.2658
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0145 0.0537
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0043 0.0153
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0047 0.021 0.0709
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0156 0.0581
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0338 0.1272
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.001 0.0029
Onchocerca volvulus 0.0084 0.0439 0.1645
Leishmania major aldo-keto reductase-like protein 0.0439 0.2659 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0037 0.0149 0.0494
Brugia malayi F/Y-rich N-terminus family protein 0.0028 0.0091 0.0335
Entamoeba histolytica acyl-coA synthetase, putative 0.0047 0.021 0.0784
Echinococcus granulosus peregrin 0.003 0.0101 0.0203
Brugia malayi Pre-SET motif family protein 0.0037 0.0149 0.0551
Plasmodium vivax hypothetical protein, conserved 0.003 0.0101 0.0334
Onchocerca volvulus Alhambra homolog 0.003 0.0101 0.0373
Entamoeba histolytica hypothetical protein 0.0024 0.0063 0.0229
Trypanosoma cruzi malate dehydrogenase, putative 0.002 0.0042 0.0151
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0002 0.0007
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0024 0.0065 0.0063
Plasmodium vivax oxidoreductase, aldo/keto reductase domain containing protein 0.0127 0.071 0.2388
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0047 0.021 0.0784
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0035 0.0136 0.0251
Treponema pallidum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0488 0.2967 1
Echinococcus granulosus aldo keto reductase 0.0439 0.2659 0.5439
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0011 0.0009
Loa Loa (eye worm) reprolysin 0.0024 0.0065 0.0237
Onchocerca volvulus 0.0015 0.001 0.0029
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0439 0.2659 1
Echinococcus granulosus FAD linked sulfhydryl oxidase ALR 0.0035 0.0134 0.027
Onchocerca volvulus 0.0015 0.001 0.0029
Brugia malayi beta-lactamase family protein 0.0037 0.0145 0.0537
Onchocerca volvulus 0.0047 0.021 0.0784
Echinococcus multilocularis aldehyde reductase 0.0312 0.1865 0.1863
Loa Loa (eye worm) glutathione reductase 0.0039 0.0156 0.0581
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0439 0.2659 0.5439
Loa Loa (eye worm) hypothetical protein 0.002 0.0042 0.0151
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0134 0.0496
Echinococcus granulosus malate dehydrogenase 0.002 0.0042 0.0082
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0029
Loa Loa (eye worm) hypothetical protein 0.0196 0.1142 0.4291
Echinococcus granulosus microtubule associated protein 2 0.067 0.4104 0.8396
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0043 0.0041
Schistosoma mansoni ryanodine receptor related 0.0025 0.007 0.0139
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0697 0.4271 0.8738
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0338 0.1272
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0124 0.0458
Schistosoma mansoni jumonji/arid domain-containing protein 0.0039 0.016 0.0323
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0043 0.0153
Trypanosoma brucei trypanothione reductase 0.0039 0.0156 0.0581
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0048 0.0217 0.0816
Onchocerca volvulus 0.0023 0.0061 0.0223
Brugia malayi Augmenter of liver regeneration 0.0035 0.0134 0.0496
Trypanosoma brucei malate dehydrogenase-related 0.002 0.0042 0.0151
Leishmania major trypanothione reductase 0.0039 0.0156 0.0581
Mycobacterium leprae conserved hypothetical protein 0.0024 0.0063 0.0212
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0439 0.2659 1
Trichomonas vaginalis esterase, putative 0.0037 0.0145 0.0544
Trichomonas vaginalis malate dehydrogenase, putative 0.0048 0.0217 0.0816
Trypanosoma cruzi aldo-keto reductase 0.0439 0.2659 1
Loa Loa (eye worm) hypothetical protein 0.0439 0.2659 1
Echinococcus granulosus cytosolic malate dehydrogenase 0.0048 0.0217 0.044
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.035 0.2102 0.4299
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0124 0.0458
Entamoeba histolytica aldose reductase, putative 0.0439 0.2659 1
Leishmania major aldo/keto reductase, putative,aldo/keto reductase family-like protein 0.0127 0.071 0.2665
Trichomonas vaginalis aldo-keto reductase, putative 0.0439 0.2659 1
Onchocerca volvulus 0.0015 0.001 0.0029
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0043 0.0041
Trichomonas vaginalis aldo-keto reductase, putative 0.0439 0.2659 1
Mycobacterium leprae PROBABLE OXIDOREDUCTASE 0.0439 0.2659 0.8962
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0011 0.0035
Brugia malayi Malate dehydrogenase, cytoplasmic 0.0048 0.0217 0.0808
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0153
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0048 0.0217 0.0808
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0145 0.0488
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0063 0.0205
Plasmodium falciparum aldo-keto reductase, putative 0.0127 0.071 0.2388
Plasmodium falciparum lactate dehydrogenase, putative 0.002 0.0042 0.0135
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0043 0.0153
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0043 0.0083
Toxoplasma gondii isocitrate dehydrogenase 0.0015 0.0011 0.0031
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0011 0.0019
Brugia malayi steroid hormone receptor 0.002 0.0043 0.0153
Loa Loa (eye worm) hypothetical protein 0.0024 0.0065 0.0237
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0084 0.0439 0.1645
Echinococcus granulosus tissue type plasminogen activator 0.0023 0.0061 0.0121
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0011 0.0019
Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0488 0.2967 1
Echinococcus granulosus ryanodine receptor 44f 0.0025 0.007 0.0139
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0088 0.0465 0.1567
Brugia malayi AMP-binding enzyme family protein 0.0047 0.021 0.0784
Brugia malayi PAN domain containing protein 0.0015 0.001 0.0029
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0301 0.1123
Brugia malayi nuclear hormone receptor 0.002 0.0043 0.0153
Loa Loa (eye worm) hypothetical protein 0.0161 0.0923 0.3465
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0439 0.2659 0.2658
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0145 0.0292
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0101 0.0099
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0399 0.0812
Entamoeba histolytica alcohol dehydrogenase, putative 0.0127 0.071 0.2665
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0145 0.0537
Entamoeba histolytica aldose reductase, putative 0.0439 0.2659 1
Schistosoma mansoni thyroid hormone receptor 0.002 0.0043 0.0083
Brugia malayi ADAMTS-like protease 0.0054 0.0254 0.0949
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0145 0.0537
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0014 0.0002 0.0007
Echinococcus granulosus hypothetical protein 0.0439 0.2659 0.5439
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0153
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0043 0.0041
Toxoplasma gondii Erv1 / Alr family protein 0.0035 0.0134 0.0445
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.001 0.0029
Schistosoma mansoni stromal cell-derived factor 2 precursor-like protein 0.0025 0.007 0.0139
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0145 0.0481
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0089 0.0475 0.0473
Loa Loa (eye worm) hypothetical protein 0.0047 0.021 0.0784
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0253 0.1494 0.5615
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0014 0.0002 0.0007
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0002 0.0007
Onchocerca volvulus 0.0439 0.2659 1
Trichomonas vaginalis aldo/keto reductase, putative 0.0439 0.2659 1
Plasmodium falciparum acyl-CoA synthetase 0.0035 0.0136 0.0451
Trichomonas vaginalis conserved hypothetical protein 0.0127 0.071 0.2671
Toxoplasma gondii PAN domain-containing protein 0.0015 0.001 0.0026
Echinococcus multilocularis aldo keto reductase 0.0439 0.2659 0.2658
Onchocerca volvulus 0.0127 0.071 0.2665
Trichomonas vaginalis malate dehydrogenase, putative 0.0048 0.0217 0.0816
Brugia malayi Pre-SET motif family protein 0.0253 0.1494 0.5615
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0056 0.0263 0.0261
Echinococcus multilocularis aldo keto reductase 0.0439 0.2659 0.2658
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0156 0.0581
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.016 0.0322
Mycobacterium leprae PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS 0.0488 0.2967 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0224 0.0835
Leishmania major aldehyde reductase, putative,oxidoreductase, putative 0.0439 0.2659 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0439 0.2659 1
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0048 0.0217 0.0816
Onchocerca volvulus 0.0439 0.2659 1
Mycobacterium leprae PROBABLE HYDROLASE 0.0196 0.1142 0.385
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0043 0.0153
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.001 0.0029
Leishmania major 4-coumarate:coa ligase-like protein 0.0047 0.021 0.0784
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.021 0.0709
Mycobacterium leprae Conserved hypothetical protein 0.0312 0.1865 0.6284
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0011 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0043 0.0153
Echinococcus multilocularis lactate dehydrogenase a 0.002 0.0042 0.004
Brugia malayi Matrixin family protein 0.039 0.2351 0.8839
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0043 0.0153
Loa Loa (eye worm) hypothetical protein 0.0051 0.0232 0.0866
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0011 0.0009
Mycobacterium tuberculosis Conserved protein 0.0127 0.071 0.2665
Echinococcus multilocularis aldo keto reductase 0.0439 0.2659 0.2658
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0002 0.0007
Trichomonas vaginalis malate dehydrogenase, putative 0.0048 0.0217 0.0816
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.0526 0.1973
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0043 0.0083
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.0524 0.0522
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0014 0.0002 0.0007
Entamoeba histolytica alcohol dehydrogenase, putative 0.0127 0.071 0.2665
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0301 0.0611
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0043 0.0153
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0301 0.0611
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0043 0.0083
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0002 0.0007
Loa Loa (eye worm) TK/ROR protein kinase 0.0023 0.0061 0.0223
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0029
Wolbachia endosymbiont of Brugia malayi 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0488 0.2967 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0032 0.0061
Onchocerca volvulus Matrilysin homolog 0.0161 0.0923 0.3465
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0024 0.0065 0.0129
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 4 0.0035 0.0134 0.0496
Mycobacterium leprae Probable lipase LipE 0.0037 0.0145 0.0488
Trypanosoma brucei mitochondrial malate dehydrogenase 0.002 0.0042 0.0151
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0014 0.0002 0.0007
Onchocerca volvulus 0.0015 0.001 0.0029
Loa Loa (eye worm) hypothetical protein 0.0037 0.0145 0.0537
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0301 0.0611
Loa Loa (eye worm) hypothetical protein 0.0015 0.001 0.0029
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0025 0.0071 0.0141
Schistosoma mansoni hypothetical protein 0.0023 0.0061 0.0121
Schistosoma mansoni hypothetical protein 0.0056 0.0263 0.0535
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0439 0.2659 0.2658
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0133 0.0267
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0697 0.4271 0.4269
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0023 0.0061 0.02
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.021 0.0709
Toxoplasma gondii oxidoreductase, aldo/keto reductase family protein 0.0127 0.071 0.2388
Loa Loa (eye worm) hypothetical protein 0.0037 0.0145 0.0537
Brugia malayi Protein kinase domain containing protein 0.0023 0.0061 0.0223
Trypanosoma cruzi aldo/keto reductase, putative 0.0127 0.071 0.2665
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0054 0.0052
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0037 0.0149 0.0146
Toxoplasma gondii microneme protein MIC17A 0.0015 0.001 0.0026
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0145 0.0292
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0043 0.0083
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0124 0.0458
Trichomonas vaginalis alcohol dehydrogenase, putative 0.0127 0.071 0.2671
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0043 0.0153
Onchocerca volvulus 0.0161 0.0923 0.3465
Schistosoma mansoni aldo-keto reductase 0.0439 0.2659 0.5439
Trichomonas vaginalis aldo-keto reductase, putative 0.0439 0.2659 1
Echinococcus granulosus cytosolic malate dehydrogenase 0.0048 0.0217 0.044
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.035 0.2102 0.2101
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0056 0.0263 0.0535
Echinococcus multilocularis stromal cell derived factor 2 0.0025 0.007 0.0068
Trichomonas vaginalis aldo-keto reductase, putative 0.0439 0.2659 1
Schistosoma mansoni nuclear hormone receptor 0.002 0.0043 0.0083
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0145 0.0544
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0014 0.0002 0.0007
Brugia malayi TAR-binding protein 0.0062 0.0301 0.1123
Onchocerca volvulus 0.0037 0.0145 0.0537
Loa Loa (eye worm) hypothetical protein 0.0161 0.0923 0.3465
Loa Loa (eye worm) hypothetical protein 0.0047 0.021 0.0784
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0043 0.0083
Schistosoma mansoni hypothetical protein 0.0795 0.4887 1
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0014 0.0002 0.0007
Toxoplasma gondii ABC1 family protein 0.0037 0.0145 0.0481
Brugia malayi jmjC domain containing protein 0.0097 0.0524 0.1962
Mycobacterium ulcerans beta-lactamase 0.0037 0.0145 0.0488
Toxoplasma gondii microneme protein MIC17B 0.0015 0.001 0.0026
Entamoeba histolytica MIR domain protein 0.0025 0.007 0.0255
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0439 0.2659 0.2658
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0439 0.2659 0.5439
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0145 0.0143
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0153
Brugia malayi Probable malate dehydrogenase, mitochondrial precursor 0.002 0.0042 0.0151
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0338 0.1272
Echinococcus multilocularis microtubule associated protein 2 0.067 0.4104 0.4102
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0043 0.0153
Toxoplasma gondii PAN domain-containing protein 0.0015 0.001 0.0026
Loa Loa (eye worm) hypothetical protein 0.0051 0.0234 0.0872
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0047 0.021 0.0709
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0439 0.2659 1
Toxoplasma gondii lactate dehydrogenase LDH2 0.002 0.0042 0.0135
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0153
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0024 0.0065 0.0129
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0015 0.0011 0.0035
Loa Loa (eye worm) hypothetical protein 0.0177 0.102 0.383
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0101 0.0334
Schistosoma mansoni thyroid hormone receptor 0.002 0.0043 0.0083
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0338 0.1272
Schistosoma mansoni cpg binding protein 0.0059 0.0285 0.0578
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0224 0.0748
Brugia malayi Isocitrate dehydrogenase 0.0015 0.0011 0.0035
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0089 0.0475 0.0968
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0063 0.0212
Trichomonas vaginalis aldo-keto reductase, putative 0.0439 0.2659 1
Onchocerca volvulus 0.0439 0.2659 1
Entamoeba histolytica malate dehydrogenase, putative 0.0048 0.0217 0.0808
Echinococcus granulosus aldo keto reductase family 1, member B4 0.0127 0.071 0.145
Loa Loa (eye worm) hypothetical protein 0.0056 0.0263 0.0983
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0074 0.0377 0.0767
Loa Loa (eye worm) PAN domain-containing protein 0.0015 0.001 0.0029
Giardia lamblia Aldose reductase 0.0439 0.2659 1
Schistosoma mansoni cpg binding protein 0.0059 0.0285 0.0578
Echinococcus multilocularis voltage gated potassium channel subunit 0.0127 0.071 0.0708
Schistosoma mansoni hypothetical protein 0.003 0.0101 0.0203
Trichomonas vaginalis malate dehydrogenase, putative 0.0038 0.0152 0.0571
Schistosoma mansoni hypothetical protein 0.0111 0.0606 0.1237
Schistosoma mansoni hypothetical protein 0.0022 0.0054 0.0106
Brugia malayi Protein-tyrosine phosphatase containing protein 0.035 0.2102 0.7904
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0043 0.0083
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0011 0.0035
Onchocerca volvulus 0.0228 0.1344 0.5049
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.0526 0.1774
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0063 0.0229
Trypanosoma cruzi cytosolic malate dehydrogenase, putative 0.0048 0.0217 0.0808
Loa Loa (eye worm) RNA binding protein 0.0062 0.0301 0.1123
Brugia malayi oxidoreductase, aldo/keto reductase family protein 0.0439 0.2659 1
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0074 0.0377 0.0375
Trichomonas vaginalis malate dehydrogenase, putative 0.0048 0.0217 0.0816
Echinococcus granulosus geminin 0.0173 0.0994 0.2031
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0145 0.0537
Onchocerca volvulus Matrilysin homolog 0.0357 0.2149 0.8081
Trichomonas vaginalis aldo-keto reductase, putative 0.0439 0.2659 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0047 0.021 0.0709
Plasmodium falciparum phd finger protein, putative 0.003 0.0101 0.0334
Toxoplasma gondii 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.0488 0.2967 1
Echinococcus multilocularis matrix metallopeptidase 7 (M10 family) 0.0586 0.3578 0.3576
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0439 0.2659 0.2658
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0032 0.003
Echinococcus multilocularis aldo keto reductase 0.0439 0.2659 0.2658
Trypanosoma brucei glycosomal malate dehydrogenase 0.002 0.0042 0.0151
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0439 0.2659 0.2658
Echinococcus granulosus voltage gated potassium channel subunit 0.0127 0.071 0.145
Onchocerca volvulus 0.0015 0.001 0.0029
Toxoplasma gondii PAN domain-containing protein 0.0015 0.001 0.0026
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0145 0.0537
Mycobacterium ulcerans 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0488 0.2967 1
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0301 0.0298
Plasmodium vivax glutathione reductase, putative 0.0039 0.0156 0.052
Toxoplasma gondii histone lysine methyltransferase SET1 0.0107 0.0585 0.1966
Trichomonas vaginalis mannosyltransferase 1, putative 0.0068 0.0338 0.1272
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0043 0.0083
Trichomonas vaginalis malate dehydrogenase, putative 0.0048 0.0217 0.0816
Brugia malayi PAN domain containing protein 0.0015 0.001 0.0029
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0145 0.0488
Leishmania major hypothetical protein, conserved 0.0049 0.0224 0.0835
Onchocerca volvulus Papilin homolog 0.0056 0.0264 0.0986
Echinococcus multilocularis dnaJ subfamily B 0.0795 0.4887 0.4886
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0439 0.2659 0.5439
Loa Loa (eye worm) hypothetical protein 0.0037 0.0145 0.0537
Loa Loa (eye worm) hypothetical protein 0.002 0.0043 0.0153
Schistosoma mansoni inositol 145-trisphosphate receptor 0.0025 0.007 0.0139
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.014 0.0138
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0043 0.0153
Onchocerca volvulus 0.0439 0.2659 1
Onchocerca volvulus 0.0439 0.2659 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0043 0.0083
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0234 0.138 0.5186
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0145 0.0544
Brugia malayi jmjC domain containing protein 0.0039 0.016 0.0595
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0011 0.0009
Mycobacterium ulcerans acyl-CoA synthetase 0.0047 0.021 0.0709
Echinococcus granulosus FTZ F1 alpha 0.002 0.0043 0.0083
Trichomonas vaginalis malate and lactate dehydrogenase, putative 0.0048 0.0217 0.0816
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.0255
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0051 0.0232 0.0471
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.035 0.2102 0.4299
Plasmodium vivax 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative 0.0488 0.2967 1
Onchocerca volvulus 0.0056 0.0265 0.0988
Echinococcus granulosus aldo keto reductase family 1 member B4 0.0439 0.2659 0.5439
Brugia malayi PAN domain containing protein 0.0015 0.001 0.0029
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0101 0.0203
Chlamydia trachomatis 1-deoxy-D-xylulose 5-phosphate reductoisomerase 0.0488 0.2967 1
Leishmania major hypothetical protein, conserved 0.0023 0.0061 0.0223
Loa Loa (eye worm) hypothetical protein 0.0037 0.0145 0.0537
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0043 0.0041
Brugia malayi beta-lactamase family protein 0.0037 0.0145 0.0537
Loa Loa (eye worm) hypothetical protein 0.0037 0.0145 0.0537
Toxoplasma gondii PAN/Apple domain-containing protein 0.0015 0.001 0.0026
Echinococcus multilocularis cytosolic malate dehydrogenase 0.0048 0.0217 0.0215
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0224 0.0748
Brugia malayi Thioredoxin reductase 0.0039 0.0156 0.0581
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.016 0.0158
Toxoplasma gondii microneme protein MIC4 0.0015 0.001 0.0026
Plasmodium vivax malate dehydrogenase, putative 0.002 0.0042 0.0135
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0043 0.0153
Echinococcus granulosus malate dehydrogenase 0.002 0.0042 0.0082
Toxoplasma gondii PAN domain-containing protein 0.0015 0.001 0.0026
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0043 0.0083
Mycobacterium ulcerans acyl-CoA synthetase 0.0014 0.0002 0.0007
Brugia malayi Kringle domain containing protein 0.0023 0.0061 0.0223
Trichomonas vaginalis antibiotic synthetase, putative 0.0014 0.0002 0.0008
Loa Loa (eye worm) malate dehydrogenase 0.0048 0.0217 0.0808
Trichomonas vaginalis mannosyltransferase 1, putative 0.0068 0.0338 0.1272
Plasmodium falciparum cysteine repeat modular protein 1 0.0023 0.0061 0.02
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0043 0.0041
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0088 0.0465 0.1742
Echinococcus multilocularis malate dehydrogenase 0.002 0.0042 0.004
Brugia malayi PAN domain containing protein 0.0015 0.001 0.0029
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0145 0.0537
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0043 0.0153
Onchocerca volvulus 0.0037 0.0145 0.0537
Brugia malayi beta-lactamase 0.0037 0.0145 0.0537
Giardia lamblia Aldose reductase 0.0439 0.2659 1
Entamoeba histolytica malate dehydrogenase, putative 0.002 0.0042 0.0151
Toxoplasma gondii kringle domain-containing protein 0.0023 0.0061 0.02
Trypanosoma cruzi glycosomal malate dehydrogenase, putative 0.002 0.0042 0.0151
Brugia malayi Matrix metalloprotease, N-terminal domain containing protein 0.0196 0.1142 0.4291
Loa Loa (eye worm) protein-tyrosine phosphatase 0.035 0.2102 0.7904
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0439 0.2659 0.2658
Echinococcus multilocularis aldo keto reductase family 1, member B4 0.0439 0.2659 0.2658
Loa Loa (eye worm) hypothetical protein 0.0047 0.021 0.0784
Schistosoma mansoni malate dehydrogenase 0.002 0.0042 0.0082
Trichomonas vaginalis dihydrodiol dehydrogenase, putative 0.0439 0.2659 1
Trichomonas vaginalis aldo-keto reductase, putative 0.0439 0.2659 1
Leishmania major hypothetical protein, conserved 0.0037 0.0145 0.0537
Trichomonas vaginalis mannosyltransferase 1, putative 0.0025 0.007 0.0263
Echinococcus multilocularis malate dehydrogenase 0.002 0.0042 0.004
Trichomonas vaginalis conserved hypothetical protein 0.0068 0.0338 0.1272
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0063 0.0212

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 4.6535 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 8.1961 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (functional) 8.9125 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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