Detailed information for compound 149071

Basic information

Technical information
  • TDR Targets ID: 149071
  • Name: tetraazanium [[2-(3,7-dimethyl-2,6-dioxopurin -1-yl)ethoxy-oxidophosphoryl]oxy-oxidophospho ryl] phosphate
  • MW: 532.278 | Formula: C9H27N8O12P3
  • H donors: 8 H acceptors: 10 LogP: -14.16 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 3
  • SMILES: O=c1n(CCOP(=O)(OP(=O)(OP(=O)(O)O)O)O)c(=O)c2c(n1C)ncn2C.N.N.N.N
  • InChi: 1S/C9H15N4O12P3.4H3N/c1-11-5-10-7-6(11)8(14)13(9(15)12(7)2)3-4-23-27(19,20)25-28(21,22)24-26(16,17)18;;;;/h5H,3-4H2,1-2H3,(H,19,20)(H,21,22)(H2,16,17,18);4*1H3
  • InChiKey: ZZARZBWBVOJMFQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • tetraammonium [[2-(3,7-dimethyl-2,6-dioxo-purin-1-yl)ethoxy-oxido-phosphoryl]oxy-oxido-phosphoryl] phosphate
  • tetraammonium [[2-(3,7-dimethyl-2,6-dioxo-1-purinyl)ethoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate
  • tetraazanium [[2-(3,7-dimethyl-2,6-dioxo-purin-1-yl)ethoxy-oxidanidyl-phosphoryl]oxy-oxidanidyl-phosphoryl] phosphate
  • tetraammonium [[2-(2,6-diketo-3,7-dimethyl-purin-1-yl)ethoxy-oxido-phosphoryl]oxy-oxido-phosphoryl] phosphate
  • tetraazanium [[2-(3,7-dimethyl-2,6-dioxo-purin-1-yl)ethoxy-oxido-phosphoryl]oxy-oxido-phosphoryl] phosphate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis lamin dm0 0.0107 0.0148 0.0175
Mycobacterium ulcerans beta-lactamase 0.0036 0.0023 0.0021
Leishmania major hypothetical protein, conserved 0.0051 0.0049 0.0915
Echinococcus multilocularis snurportin 1 0.0303 0.0496 0.0583
Echinococcus granulosus tumor protein p63 0.0693 0.1187 0.1397
Brugia malayi TAR-binding protein 0.0061 0.0068 0.0321
Echinococcus multilocularis importin subunit beta 1 0.0028 0.001 0.0012
Echinococcus granulosus mothers against decapentaplegic 2 0.0036 0.0024 0.0028
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0047 0.0042 0.8289
Loa Loa (eye worm) MH1 domain-containing protein 0.0081 0.0103 0.049
Trypanosoma brucei nucleotidyl transferase, putative 0.0029 0.001 0.0045
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0068 0.0081
Echinococcus granulosus tar DNA binding protein 0.0061 0.0068 0.0081
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0023 0.0102
Toxoplasma gondii isocitrate dehydrogenase 0.0047 0.0042 0.0208
Brugia malayi Pip kinase protein 2 0.0157 0.0238 0.1144
Entamoeba histolytica ankyrin, putative 0.0027 0.0008 0.0219
Echinococcus multilocularis survival motor neuron protein 1 0.0487 0.0821 0.0967
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.02 0.0314 0.037
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.005 0.0048 0.0057
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0023 0.0021
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0069 0.1164
Loa Loa (eye worm) glutaminase 0.028 0.0456 0.2198
Chlamydia trachomatis UDP-3-O-acylglucosamine N-acyltransferase 0.0027 0.0008 0.5
Schistosoma mansoni mannose-1-phosphate guanyltransferase 0.0029 0.001 0.0012
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0057 0.006 0.0281
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0023 0.0021
Brugia malayi GDP-mannose pyrophosphorylase B 0.0029 0.001 0.004
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0107 0.0148 0.0709
Loa Loa (eye worm) hypothetical protein 0.0553 0.0939 0.454
Schistosoma mansoni hypothetical protein 0.0378 0.0629 0.0741
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0023 0.0027
Loa Loa (eye worm) hypothetical protein 0.0027 0.0008 0.0029
Trypanosoma cruzi major cysteine proteinase, putative 0.0049 0.0046 0.085
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0008 0.0142
Loa Loa (eye worm) nuclear factor I 0.0045 0.0039 0.0179
Echinococcus multilocularis mannose 1 phosphate guanyltransferase 0.0029 0.001 0.0012
Mycobacterium leprae PROBABLE SERINE ACETYLTRANSFERASE CYSE (SAT) 0.0027 0.0008 0.0006
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0048 0.0057
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0057 0.006 0.1111
Echinococcus granulosus transcription factor eb 0.0106 0.0148 0.0174
Brugia malayi MH1 domain containing protein 0.0081 0.0103 0.049
Brugia malayi hypothetical protein 0.0155 0.0234 0.1122
Echinococcus multilocularis mannose 1 phosphate guanyltransferase beta 0.0029 0.001 0.0012
Mycobacterium ulcerans hypothetical protein 0.0027 0.0008 0.0006
Leishmania major hypothetical protein, conserved 0.0036 0.0023 0.0427
Entamoeba histolytica maltose O-acetyltransferase, putative 0.0027 0.0008 0.0219
Trichomonas vaginalis mannose-1-phosphate guanyltransferase, putative 0.0027 0.0008 0.0166
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0023 0.0427
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0023 0.0501
Leishmania major trypanothione reductase 0.0046 0.0041 0.0758
Onchocerca volvulus 0.0157 0.0238 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.032 0.0526 0.0619
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0069 0.1164
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0218 0.0346 0.0408
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0069 0.1289
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0157 0.0238 0.028
Echinococcus multilocularis smad 0.0081 0.0103 0.0122
Schistosoma mansoni intermediate filament proteins 0.0107 0.0148 0.0175
Loa Loa (eye worm) hypothetical protein 0.0036 0.0023 0.0102
Mycobacterium ulcerans hypothetical protein 0.0036 0.0023 0.0021
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.0166 0.0164
Mycobacterium tuberculosis Conserved protein 0.0036 0.0023 0.0021
Brugia malayi hypothetical protein 0.0027 0.0008 0.0029
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0047 0.0042 0.005
Mycobacterium ulcerans hypothetical protein 0.0171 0.0263 0.0261
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0002 0.0032
Echinococcus multilocularis Smad4 0.0081 0.0103 0.0122
Trypanosoma cruzi hypothetical protein 0.0027 0.0008 0.0142
Brugia malayi MH2 domain containing protein 0.0081 0.0103 0.049
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0325 0.0535 1
Plasmodium vivax mannose-1-phosphate guanyltransferase, putative 0.0029 0.001 0.0572
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0046 0.0041 0.0752
Schistosoma mansoni smad1 5 8 and 0.0081 0.0103 0.0122
Mycobacterium ulcerans lipase LipD 0.0036 0.0023 0.0021
Treponema pallidum licC protein (licC) 0.0956 0.1652 0.5
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0002 0.0049
Plasmodium falciparum mannose-1-phosphate guanyltransferase, putative 0.0029 0.001 0.0572
Brugia malayi Intermediate filament tail domain containing protein 0.0107 0.0148 0.0709
Loa Loa (eye worm) hypothetical protein 0.0051 0.0049 0.0229
Echinococcus multilocularis SAM and MBT domain containing protein 0.005 0.0048 0.0057
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0041 0.0188
Onchocerca volvulus 0.0099 0.0136 0.565
Brugia malayi RNA binding protein 0.0061 0.0068 0.0321
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0553 0.0939 0.454
Entamoeba histolytica maltose O-acetyltransferase, putative 0.0027 0.0008 0.0219
Echinococcus multilocularis histone acetyltransferase MYST2 0.0057 0.006 0.0071
Giardia lamblia Translation initiation factor 0.0027 0.0008 0.5
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0042 0.005
Mycobacterium tuberculosis Probable reductase 0.0105 0.0145 0.0143
Mycobacterium tuberculosis Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU 0.5673 1 1
Entamoeba histolytica bacterial transferase hexapeptide family protein 0.0027 0.0008 0.0219
Echinococcus multilocularis mothers against decapentaplegic 6 0.0036 0.0024 0.0028
Entamoeba histolytica serine acetyltransferase 1 0.0027 0.0008 0.0219
Echinococcus multilocularis microtubule associated protein 2 0.4823 0.8495 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.032 0.0526 0.0619
Brugia malayi glutathione reductase 0.0046 0.0041 0.0188
Loa Loa (eye worm) hypothetical protein 0.0155 0.0234 0.1122
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0553 0.0939 0.454
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0325 0.0535 1
Echinococcus granulosus lamin dm0 0.0107 0.0148 0.0175
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0069 0.1289
Mycobacterium tuberculosis Conserved protein 0.0036 0.0023 0.0021
Echinococcus multilocularis geminin 0.0687 0.1175 0.1383
Echinococcus granulosus expressed conserved protein 0.0136 0.0201 0.0236
Chlamydia trachomatis acyl-ACP--UDP-N-acetylglucosamine O-acyltransferase 0.0027 0.0008 0.5
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0002 0.0032
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0023 0.0021
Schistosoma mansoni phosphatidylinositol-4-phosphate 5-kinase type II 0.0157 0.0238 0.028
Mycobacterium ulcerans molybdopterin-guanine dinucleotide biosynthesis protein A 0.0956 0.1652 0.1651
Trichomonas vaginalis sugar-1-phosphate guanyl transferase, putative 0.0029 0.001 0.0218
Mycobacterium tuberculosis Possible transferase 0.0027 0.0008 0.0006
Entamoeba histolytica serine acetyltransferase 1 0.0027 0.0008 0.0219
Loa Loa (eye worm) glutathione reductase 0.0046 0.0041 0.0188
Onchocerca volvulus 0.0107 0.0148 0.6198
Brugia malayi Calcitonin receptor-like protein seb-1 0.0553 0.0939 0.454
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0042 0.065
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.032 0.0526 0.0619
Schistosoma mansoni lamin 0.0107 0.0148 0.0175
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0303 0.0496 0.2392
Schistosoma mansoni hypothetical protein 0.0687 0.1175 0.1383
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0023 0.0501
Echinococcus granulosus mothers against decapentaplegic 6 0.0036 0.0024 0.0028
Schistosoma mansoni glucosamine-1-phosphate N-acetyltransferase 0.0029 0.001 0.0012
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0023 0.0021
Leishmania major hypothetical protein, conserved 0.0027 0.0008 0.0142
Loa Loa (eye worm) dynactin 5 0.0027 0.0008 0.0029
Trypanosoma brucei GDP-mannose pyrophosphorylase 0.0029 0.001 0.0045
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0047 0.0042 0.005
Schistosoma mansoni smad1 5 8 and 0.0081 0.0103 0.0122
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0049 0.0915
Echinococcus granulosus mannose 1 phosphate guanyltransferase beta 0.0027 0.0008 0.001
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0008 0.0166
Onchocerca volvulus 0.0101 0.0139 0.5815
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.001 0.0036
Echinococcus granulosus Smad4 0.0081 0.0103 0.0122
Plasmodium vivax importin-beta 2, putative 0.0028 0.001 0.0463
Toxoplasma gondii GDP-D-mannose pyrophosphorylase 0.0029 0.001 0.0014
Mycobacterium tuberculosis Conserved hypothetical protein 0.0171 0.0263 0.0261
Leishmania major hypothetical protein, conserved 0.0027 0.0008 0.0142
Loa Loa (eye worm) hypothetical protein 0.0036 0.0023 0.0102
Brugia malayi Nucleotidyl transferase family protein 0.0029 0.001 0.004
Entamoeba histolytica hypothetical protein 0.0218 0.0346 1
Brugia malayi cytoplasmic intermediate filament protein 0.0057 0.0061 0.0284
Mycobacterium tuberculosis Probable serine acetyltransferase CysE (sat) 0.0027 0.0008 0.0006
Brugia malayi MH2 domain containing protein 0.0081 0.0103 0.049
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0069 0.1164
Brugia malayi MH1 domain containing protein 0.0045 0.0039 0.0179
Trichomonas vaginalis esterase, putative 0.0036 0.0023 0.0501
Echinococcus granulosus lamin 0.0107 0.0148 0.0175
Loa Loa (eye worm) MH2 domain-containing protein 0.0081 0.0103 0.049
Brugia malayi hypothetical protein 0.0027 0.0008 0.0029
Mycobacterium ulcerans d-alpha-D-mannose-1-phosphate guanylyltransferase ManB 0.0029 0.001 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0069 0.1164
Entamoeba histolytica bacterial transferase hexapeptide family protein 0.0027 0.0008 0.0219
Plasmodium falciparum thioredoxin reductase 0.0046 0.0041 0.7974
Leishmania major cathepsin L-like protease 0.0062 0.0069 0.1289
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0068 0.0081
Entamoeba histolytica acetyltransferase, putative 0.0027 0.0008 0.0219
Entamoeba histolytica acetyltransferase, putative 0.0027 0.0008 0.0219
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.001 0.0012
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0069 0.1164
Echinococcus multilocularis mothers against decapentaplegic 2 0.0036 0.0024 0.0028
Loa Loa (eye worm) hypothetical protein 0.0105 0.0145 0.0692
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0023 0.0501
Mycobacterium ulcerans hypothetical protein 0.0956 0.1652 0.1651
Echinococcus multilocularis lamin 0.0107 0.0148 0.0175
Loa Loa (eye worm) latrophilin receptor protein 2 0.0175 0.027 0.1296
Loa Loa (eye worm) helix-loop-helix DNA-binding domain-containing protein 0.0106 0.0147 0.0701
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0049 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0061 0.0068 0.0321
Brugia malayi intermediate filament protein 0.0107 0.0148 0.0709
Schistosoma mansoni hypothetical protein 0.0027 0.0008 0.001
Schistosoma mansoni hypothetical protein 0.0175 0.027 0.0317
Entamoeba histolytica acetyltransferase, putative 0.0027 0.0008 0.0219
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.0166 0.0164
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0023 0.0021
Loa Loa (eye worm) hypothetical protein 0.0028 0.001 0.0038
Schistosoma mansoni Smad4 0.0036 0.0024 0.0028
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0145 0.0143
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.032 0.0526 0.0619
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0042 0.005
Onchocerca volvulus 0.0036 0.0023 0.0895
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0008 0.0142
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.032 0.0526 0.0619
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0023 0.0021
Brugia malayi Thioredoxin reductase 0.0046 0.0041 0.0188
Plasmodium vivax glutathione reductase, putative 0.0046 0.0041 0.7974
Echinococcus multilocularis tar DNA binding protein 0.0061 0.0068 0.0081
Loa Loa (eye worm) RNA binding protein 0.0061 0.0068 0.0321
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0047 0.0042 0.004
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0046 0.0041 0.0619
Onchocerca volvulus Mothers against decapentaplegic homolog 0.0036 0.0024 0.0921
Schistosoma mansoni dynactin subunit P25 0.0027 0.0008 0.001
Schistosoma mansoni myelin transcription factor 1 myt1 0.0057 0.006 0.0071
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0047 0.0042 0.0783
Trichomonas vaginalis glucose-1-phosphate thymidylyltransferase, putative 0.0029 0.001 0.0218
Loa Loa (eye worm) hypothetical protein 0.0036 0.0023 0.0102
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0042 0.0783
Loa Loa (eye worm) hypothetical protein 0.0378 0.0629 0.3039
Mycobacterium ulcerans serine acetyltransferase CysE 0.0027 0.0008 0.0006
Echinococcus granulosus importin subunit beta 1 0.0028 0.001 0.0012
Echinococcus granulosus microtubule associated protein 2 0.4823 0.8495 1
Trypanosoma cruzi GDP-mannose pyrophosphorylase 0.0029 0.001 0.0186
Echinococcus multilocularis mannose 1 phosphate guanyltransferase beta 0.0027 0.0008 0.001
Brugia malayi mothers against decapentaplegic homolog 3 0.0036 0.0024 0.0105
Schistosoma mansoni smad 0.0036 0.0024 0.0028
Echinococcus multilocularis mothers against decapentaplegic 5 0.0081 0.0103 0.0122
Loa Loa (eye worm) hypothetical protein 0.0027 0.0008 0.0029
Mycobacterium ulcerans transferase 0.0027 0.0008 0.0006
Schistosoma mansoni Smad4 0.0036 0.0024 0.0028
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0023 0.3687
Echinococcus granulosus sentrin specific protease 7 0.0149 0.0224 0.0264
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0049 0.0915
Loa Loa (eye worm) hypothetical protein 0.0051 0.0051 0.0236
Plasmodium falciparum glutathione reductase 0.0046 0.0041 0.7974
Trypanosoma cruzi GDP-mannose pyrophosphorylase 0.0029 0.001 0.0186
Loa Loa (eye worm) pip kinase 2 0.0157 0.0238 0.1144
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0023 0.0021
Loa Loa (eye worm) Smad1 0.0081 0.0103 0.049
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0081 0.0103 0.0122
Schistosoma mansoni glutaminase 0.028 0.0456 0.0536
Brugia malayi latrophilin 2 splice variant baaae 0.0378 0.0629 0.3039
Mycobacterium tuberculosis Conserved hypothetical protein 0.0956 0.1652 0.1651
Schistosoma mansoni hypothetical protein 0.0218 0.0346 0.0408
Trypanosoma cruzi serine acetyltransferase, putative 0.0027 0.0008 0.0142
Echinococcus multilocularis expressed conserved protein 0.0136 0.0201 0.0236
Mycobacterium leprae POSSIBLE TRANSFERASE 0.0027 0.0008 0.0006
Trypanosoma brucei trypanothione reductase 0.0046 0.0041 0.0625
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0068 0.0081
Leishmania major GDP-mannose pyrophosphorylase 0.0029 0.001 0.0186
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.032 0.0526 0.2539
Loa Loa (eye worm) intermediate filament protein 0.0107 0.0148 0.0709
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0049 0.0251
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0069 0.1289
Trypanosoma cruzi serine acetyltransferase, putative 0.0027 0.0008 0.0142
Loa Loa (eye worm) hypothetical protein 0.0045 0.0039 0.0179
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0145 0.0143
Echinococcus granulosus intermediate filament protein 0.0107 0.0148 0.0175
Trypanosoma cruzi Translation initiation factor eIF-2B subunit epsilon, putative 0.0029 0.001 0.0186
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0049 0.0784
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0041 0.0048
Onchocerca volvulus 0.0036 0.0023 0.0895
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0041 0.0048
Loa Loa (eye worm) hypothetical protein 0.0487 0.0821 0.3971
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0069 0.1164
Brugia malayi hypothetical protein 0.0033 0.0018 0.0075
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0047 0.0042 0.0783
Schistosoma mansoni transcription factor LCR-F1 0.0218 0.0346 0.0408
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0023 0.0289
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0154 0.0232 0.4332
Echinococcus granulosus mannose 1 phosphate guanyltransferase 0.0029 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0049 0.0047 0.0219
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.005 0.0048 0.1941
Schistosoma mansoni hypothetical protein 0.0175 0.027 0.0317
Loa Loa (eye worm) MH1 domain-containing protein 0.0036 0.0024 0.0105
Loa Loa (eye worm) hypothetical protein 0.0107 0.0148 0.0709
Leishmania major serine acetyltransferase 0.0027 0.0008 0.0142
Onchocerca volvulus 0.0107 0.0148 0.6198
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0008 0.0142
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0051 0.0051 0.006
Schistosoma mansoni gdp-mannose pyrophosphorylase b isoform 2 0.0029 0.001 0.0012
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0041 0.0039
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0218 0.0346 0.0408
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0057 0.006 0.0071
Echinococcus multilocularis sentrin specific protease 7 0.0149 0.0224 0.0264
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0175 0.027 0.0317
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.032 0.0526 0.0619
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0154 0.0232 0.4332
Echinococcus granulosus GPCR family 2 0.0175 0.027 0.0317
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.032 0.0526 0.0619
Brugia malayi glutaminase DH11.1 0.028 0.0456 0.2198
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.032 0.0526 0.2539
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0047 0.0042 0.8289
Loa Loa (eye worm) TAR-binding protein 0.0061 0.0068 0.0321
Echinococcus multilocularis phosphatidylinositol 5 phosphate 4 kinase type 2 0.0157 0.0238 0.028
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0068 0.0081
Entamoeba histolytica acetyltransferase, putative 0.0027 0.0008 0.0219
Echinococcus multilocularis transcription factor eb 0.0106 0.0148 0.0174
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0099 0.0136 0.0646
Schistosoma mansoni hypothetical protein 0.0099 0.0136 0.016
Brugia malayi RNA recognition motif domain containing protein 0.0061 0.0068 0.0321
Echinococcus multilocularis tumor protein p63 0.0693 0.1187 0.1397
Schistosoma mansoni hypothetical protein 0.0175 0.027 0.0317
Entamoeba histolytica acetyltransferase, putative 0.0027 0.0008 0.0219
Trichomonas vaginalis glutaminase, putative 0.028 0.0456 1
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0027 0.0008 0.001
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0049 1
Echinococcus granulosus survival motor neuron protein 1 0.0487 0.0821 0.0967
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0023 0.0021
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0057 0.006 0.0071
Mycobacterium leprae Probable lipase LipE 0.0036 0.0023 0.0021
Brugia malayi mbt repeat family protein 0.005 0.0048 0.0222
Entamoeba histolytica acetyltransferase, putative 0.0027 0.0008 0.0219
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0069 0.1164
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0069 0.1164
Brugia malayi hypothetical protein 0.0051 0.0049 0.0229
Brugia malayi Latrophilin receptor protein 2 0.0175 0.027 0.1296
Mycobacterium ulcerans bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 0.5673 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0175 0.027 0.0317
Onchocerca volvulus 0.0036 0.0023 0.0895
Brugia malayi beta-lactamase family protein 0.0036 0.0023 0.0102
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.5673 1 1
Trichomonas vaginalis maltose O-acetyltransferase, putative 0.0027 0.0008 0.0166
Loa Loa (eye worm) beta-lactamase 0.0036 0.0023 0.0102
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0145 0.0143
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0002 0.0049
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0047 0.0042 0.005
Schistosoma mansoni survival motor neuron protein 0.0099 0.0136 0.016
Brugia malayi Helix-loop-helix DNA-binding domain containing protein 0.0106 0.0148 0.0705
Mycobacterium tuberculosis Possible siderophore-binding protein 0.0027 0.0008 0.0006
Trypanosoma cruzi hypothetical protein, conserved 0.0027 0.0008 0.0142
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0041 0.0758
Loa Loa (eye worm) isocitrate dehydrogenase 0.0047 0.0042 0.0195
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0041 0.7974
Echinococcus granulosus smad 0.0081 0.0103 0.0122
Schistosoma mansoni smad1 5 8 and 0.0081 0.0103 0.0122
Brugia malayi Importin beta-1 subunit 0.0028 0.001 0.0038
Echinococcus multilocularis musashi 0.0107 0.0148 0.0175
Loa Loa (eye worm) hypothetical protein 0.0036 0.0023 0.0102
Brugia malayi isocitrate dehydrogenase 0.0047 0.0042 0.0195
Brugia malayi Smad1 0.0081 0.0103 0.049
Echinococcus granulosus TGF beta signal transducer SmadC 0.0081 0.0103 0.0122
Toxoplasma gondii eukaryotic initiation factor-2B, gamma subunit, putative 0.0956 0.1652 1
Loa Loa (eye worm) hypothetical protein 0.0106 0.0147 0.0701
Entamoeba histolytica hypothetical protein 0.0218 0.0346 1
Mycobacterium ulcerans non-ribosomal peptide synthetase 0.0028 0.001 0.0008
Loa Loa (eye worm) MBCTL1 0.0057 0.006 0.0281
Leishmania major mitochondrial DNA polymerase beta 0.0325 0.0535 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0325 0.0535 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0023 0.0102
Trichomonas vaginalis maltose O-acetyltransferase, putative 0.0027 0.0008 0.0166
Loa Loa (eye worm) transcription factor SMAD2 0.119 0.2065 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0041 0.0752
Echinococcus granulosus dynactin 5 p25 0.0027 0.0008 0.001
Schistosoma mansoni hypothetical protein 0.0175 0.027 0.0317
Leishmania major hypothetical protein, conserved 0.0027 0.0008 0.0142
Schistosoma mansoni hypothetical protein 0.0307 0.0503 0.0592
Loa Loa (eye worm) hypothetical protein 0.0157 0.0238 0.1144
Loa Loa (eye worm) hypothetical protein 0.0036 0.0024 0.0105
Entamoeba histolytica hypothetical protein 0.0218 0.0346 1
Toxoplasma gondii isocitrate dehydrogenase 0.0047 0.0042 0.0208
Echinococcus multilocularis polycomb protein SCMH1 0.005 0.0048 0.0057
Leishmania major cathepsin L-like protease 0.0062 0.0069 0.1289
Loa Loa (eye worm) hypothetical protein 0.0057 0.006 0.0281
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0149 0.0224 0.0264
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0069 0.1164
Echinococcus multilocularis isocitrate dehydrogenase 0.0047 0.0042 0.005
Schistosoma mansoni hypothetical protein 0.0303 0.0496 0.0583
Brugia malayi MH1 domain containing protein 0.0081 0.0103 0.049
Echinococcus granulosus phosphatidylinositol 5 phosphate 4 kinase type 2 0.0157 0.0238 0.028
Mycobacterium tuberculosis Conserved hypothetical protein 0.0956 0.1652 0.1651
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0056 0.0058 0.1083
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0175 0.027 0.1296
Schistosoma mansoni hypothetical protein 0.0687 0.1175 0.1383
Brugia malayi MH1 domain containing protein 0.0045 0.0039 0.0179
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0051 0.0051 0.006
Echinococcus granulosus polycomb protein SCMH1 0.005 0.0048 0.0057
Echinococcus granulosus endonuclease exonuclease phosphatase 0.02 0.0314 0.037
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.001 0.0036
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0023 0.0027
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.0166 0.0164
Leishmania major cathepsin L-like protease 0.0062 0.0069 0.1289
Mycobacterium tuberculosis Conserved protein 0.0036 0.0023 0.0021
Schistosoma mansoni sex comb on midleg homolog 0.005 0.0048 0.0057
Echinococcus multilocularis dynactin 5 p25 0.0027 0.0008 0.001
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.0166 0.0164
Toxoplasma gondii thioredoxin reductase 0.0046 0.0041 0.02
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0145 0.0143
Entamoeba histolytica translation initiation factor eIF-2B epsilon subunit, putative 0.0029 0.001 0.0287
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0023 0.0102
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0057 0.0061 0.0284
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0175 0.027 0.0317
Brugia malayi eIF4-gamma/eIF5/eIF2-epsilon family protein 0.0027 0.0008 0.0029
Brugia malayi Isocitrate dehydrogenase 0.0047 0.0042 0.0195
Loa Loa (eye worm) mbt repeat family protein 0.005 0.0048 0.0222
Schistosoma mansoni cellular tumor antigen P53 0.0101 0.0139 0.0164
Loa Loa (eye worm) GDP-mannose pyrophosphorylase B 0.0029 0.001 0.004
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0023 0.0027
Brugia malayi hypothetical protein 0.0218 0.0346 0.1669
Echinococcus granulosus histone acetyltransferase MYST2 0.0057 0.006 0.0071
Mycobacterium ulcerans hypothetical protein 0.0956 0.1652 0.1651
Entamoeba histolytica serine acetyltransferase, putative 0.0027 0.0008 0.0219
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0069 0.1289
Onchocerca volvulus 0.005 0.0048 0.1941
Loa Loa (eye worm) hypothetical protein 0.0175 0.027 0.1296
Mycobacterium tuberculosis Conserved hypothetical protein 0.0027 0.0008 0.0006
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0175 0.027 0.0317
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0047 0.0042 0.005
Echinococcus granulosus snurportin 1 0.0303 0.0496 0.0583
Brugia malayi RNA, U transporter 1 0.0081 0.0103 0.0486
Plasmodium falciparum importin beta, putative 0.0028 0.001 0.0463
Brugia malayi hypothetical protein 0.0487 0.0821 0.3971
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0081 0.0103 0.0122
Loa Loa (eye worm) GDP-mannose pyrophosphorylase B 0.0027 0.0008 0.0029
Toxoplasma gondii hypothetical protein 0.0052 0.0053 0.0271
Brugia malayi zgc:92842 0.0027 0.0008 0.0029
Toxoplasma gondii ABC1 family protein 0.0036 0.0023 0.0093
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0023 0.0501
Onchocerca volvulus 0.0155 0.0234 0.9811
Loa Loa (eye worm) glutaminase 2 0.028 0.0456 0.2198
Brugia malayi beta-lactamase family protein 0.0036 0.0023 0.0102
Loa Loa (eye worm) hypothetical protein 0.0036 0.0023 0.0102
Schistosoma mansoni microtubule-associated protein tau 0.4823 0.8495 1
Echinococcus granulosus mannose 1 phosphate guanyltransferase beta 0.0029 0.001 0.0012
Brugia malayi MH2 domain containing protein 0.0036 0.0024 0.0105
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0002 0.0049
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0002 0.0032
Brugia malayi hypothetical protein 0.0027 0.0008 0.0029
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0149 0.0224 0.6458
Echinococcus multilocularis GPCR, family 2 0.0175 0.027 0.0317
Brugia malayi mbt repeat family protein 0.005 0.0048 0.0222
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0023 0.0501
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0023 0.0021
Schistosoma mansoni lamin 0.0107 0.0148 0.0175
Schistosoma mansoni importin beta-1 0.0028 0.001 0.0012
Entamoeba histolytica hypothetical protein 0.0218 0.0346 1
Loa Loa (eye worm) hypothetical protein 0.0101 0.0139 0.0665
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0047 0.0042 0.065
Echinococcus granulosus geminin 0.0687 0.1175 0.1383
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0145 0.0143
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.0366 0.0363
Echinococcus granulosus mothers against decapentaplegic 5 0.0081 0.0103 0.0122
Echinococcus granulosus SAM and MBT domain containing protein 0.005 0.0048 0.0057
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.4105 0.7225 0.8504
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0069 0.1164
Loa Loa (eye worm) MH2 domain-containing protein 0.0036 0.0024 0.0105
Brugia malayi hypothetical protein 0.0027 0.0008 0.0029
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0154 0.0232 0.425
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0145 0.0143
Brugia malayi MH2 domain containing protein 0.119 0.2065 1
Schistosoma mansoni Smad4 0.0081 0.0103 0.0122
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0046 0.0041 0.0752
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0023 0.0027
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0023 0.0021
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0023 0.0427
Mycobacterium ulcerans glutaminase 0.028 0.0456 0.0454
Loa Loa (eye worm) hypothetical protein 0.005 0.0048 0.0222
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0049 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0069 0.1164
Loa Loa (eye worm) MH2 domain-containing protein 0.119 0.2065 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0047 0.0219
Schistosoma mansoni tar DNA-binding protein 0.0061 0.0068 0.0081
Brugia malayi beta-lactamase 0.0036 0.0023 0.0102
Schistosoma mansoni smad 0.0081 0.0103 0.0122
Loa Loa (eye worm) nucleotidyl transferase 0.0029 0.001 0.004

Activities

Activity type Activity value Assay description Source Reference
Ca2+ elevation (functional) = 54 nM Compound was evaluated in vitro for its effect on intracellular ca++ elevation was determined in comparison to the ATP at 10 uM on rat cardiomyocytes; Ca++ elevation ChEMBL. 10411489
Inhibition (functional) 0 Inhibition of Ca++ elevation was determined in CPX treated cardiac cells in rat; Complete inhibition ChEMBL. 10411489
Inhibition (functional) 0 Inhibition of Ca++ elevation was determined in PPADS treated cardiac cells in rat; No inhibition ChEMBL. 10411489
Reduction of heart rate (functional) = 3 % Compound was evaluated 1 min after drug application on rat cardiomyocytes ChEMBL. 10411489

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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