TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 286.452 | Formula: C20H30O
H donors: 0 H acceptors: 1 LogP: 4.76 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: C/C/1=C/C[C@@]2(C)C(=O)C[C@@H]([C@@H]2CC/C(=C/CC1)/C)C(=C)C
InChi: 1S/C20H30O/c1-14(2)17-13-19(21)20(5)12-11-16(4)8-6-7-15(3)9-10-18(17)20/h7,11,17-18H,1,6,8-10,12-13H2,2-5H3/b15-7+,16-11-/t17-,18+,20-/m1/s1
InChiKey: RNHJVFUOEQKJEA-SQJFUGCSSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0025	0.0124	0.006
Toxoplasma gondii	hypothetical protein	0.0025	0.0124	0.006
Schistosoma mansoni	peter pan-related	0.0025	0.0124	0.006
Giardia lamblia	Hypothetical protein	0.0025	0.0124	0.5
Echinococcus granulosus	E3 ubiquitin protein ligase MYLIP	0.0025	0.0124	0.0123
Mycobacterium ulcerans	acyl-CoA synthetase	0.0022	0.01	0.1394
Onchocerca volvulus		0.0026	0.0133	0.0069
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0124	0.0123
Schistosoma mansoni	patched 1	0.0039	0.0223	0.016
Brugia malayi	Matrixin family protein	0.0018	0.0072	0.0072
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0124	0.0123
Toxoplasma gondii	hypothetical protein	0.0025	0.0124	0.006
Schistosoma mansoni	hypothetical protein	0.0025	0.0124	0.006
Echinococcus multilocularis	ring finger protein 170	0.0025	0.0124	0.0123
Plasmodium falciparum	plasmepsin II	0.0017	0.0064	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0114	0.0113
Brugia malayi	hypothetical protein	0.0025	0.0124	0.0124
Echinococcus granulosus	cpg binding protein	0.0028	0.0144	0.0143
Giardia lamblia	Hypothetical protein	0.0025	0.0124	0.5
Onchocerca volvulus	Protein neuralized homolog	0.0025	0.0124	0.006
Loa Loa (eye worm)	hypothetical protein	0.0493	0.352	0.3519
Entamoeba histolytica	zinc finger domain containing protein	0.0025	0.0124	0.0481
Onchocerca volvulus		0.0493	0.352	0.3478
Trypanosoma cruzi	hypothetical protein, conserved	0.0493	0.352	1
Plasmodium vivax	plasmepsin V, putative	0.0017	0.0064	0.0005
Trichomonas vaginalis	conserved hypothetical protein	0.1387	1	1
Plasmodium vivax	plasmepsin IV, putative	0.0017	0.0064	0.0005
Schistosoma mansoni	cpg binding protein	0.0026	0.0133	0.0069
Giardia lamblia	Protein 21.1	0.0025	0.0124	0.5
Echinococcus multilocularis	Upstream activation factor subunit UAF30	0.1387	1	1
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0223	0.0222
Echinococcus multilocularis	protein patched	0.0039	0.0223	0.0222
Giardia lamblia	Zinc finger domain	0.0025	0.0124	0.5
Loa Loa (eye worm)	hypothetical protein	0.0016	0.006	0.0059
Echinococcus multilocularis	Blood coagulation inhibitor, Disintegrin	0.0058	0.0363	0.0362
Loa Loa (eye worm)	reprolysin	0.0024	0.0114	0.0113
Brugia malayi	AMP-binding enzyme family protein	0.0022	0.01	0.01
Plasmodium vivax	zinc finger protein, putative	0.0025	0.0124	0.0064
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.0092	0.0608	0.0547
Echinococcus granulosus	E3 ubiquitin protein ligase mib1	0.0025	0.0124	0.0123
Onchocerca volvulus		0.0018	0.0072	0.0008
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0091	0.0598	1
Onchocerca volvulus	RING finger protein 141 homolog	0.0025	0.0124	0.006
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0493	0.352	1
Leishmania major	hypothetical protein, conserved	0.0025	0.0124	0.007
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0056	0.0346	1
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0493	0.352	0.352
Plasmodium falciparum	plasmepsin IV	0.0017	0.0064	0.0005
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0056	0.0346	1
Echinococcus granulosus	Niemann Pick C1 protein	0.0129	0.088	0.0879
Giardia lamblia	Protein 21.1	0.0025	0.0124	0.5
Trichomonas vaginalis	ankyrin, putative	0.0025	0.0124	0.006
Loa Loa (eye worm)	disintegrin family protein	0.0063	0.0402	0.0401
Trypanosoma brucei	hypothetical protein, conserved	0.0493	0.352	1
Onchocerca volvulus		0.0044	0.0263	0.02
Trypanosoma brucei	mitochondrial RNA binding complex 1 subunit	0.0493	0.352	1
Entamoeba histolytica	hypothetical protein	0.0025	0.0124	0.0481
Brugia malayi	CHE-14 protein	0.0039	0.0223	0.0223
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Toxoplasma gondii	hypothetical protein	0.0025	0.0124	0.006
Loa Loa (eye worm)	hypothetical protein	0.0016	0.006	0.0059
Echinococcus multilocularis	zinc finger protein Ran binding	0.0493	0.352	0.3519
Echinococcus granulosus	ring finger protein 170	0.0025	0.0124	0.0123
Echinococcus multilocularis	survival motor neuron protein 1	0.0217	0.1518	0.1518
Leishmania major	hypothetical protein, conserved	0.0493	0.352	1
Echinococcus multilocularis	subfamily M12B unassigned peptidase	0.0024	0.0114	0.0113
Brugia malayi	Hypothetical RING finger protein C16C10.7 in chromosome III	0.0025	0.0124	0.0124
Toxoplasma gondii	zinc finger, C3HC4 type (RING finger) domain-containing protein	0.0025	0.0124	0.006
Giardia lamblia	Protein 21.1	0.0025	0.0124	0.5
Echinococcus granulosus	dnaJ subfamily B	0.0376	0.2669	0.2668
Giardia lamblia	Protein 21.1	0.0025	0.0124	0.5
Giardia lamblia	Protein 21.1	0.0025	0.0124	0.5
Echinococcus multilocularis	sterol regulatory element binding protein	0.0039	0.0223	0.0222
Giardia lamblia	Protein 21.1	0.0025	0.0124	0.5
Plasmodium falciparum	plasmepsin I	0.0017	0.0064	0.0005
Echinococcus granulosus	expressed conserved protein	0.0085	0.0558	0.0557
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0124	0.0123
Schistosoma mansoni	serine/threonine protein kinase	0.0025	0.0124	0.006
Brugia malayi	Eukaryotic aspartyl protease family protein	0.0017	0.0064	0.0064
Echinococcus multilocularis	Zinc finger, RanBP2 type	0.0493	0.352	0.3519
Schistosoma mansoni	adam (A disintegrin and metalloprotease	0.0041	0.0242	0.0179
Loa Loa (eye worm)	hypothetical protein	0.0217	0.1518	0.1518
Echinococcus granulosus	Zinc finger RanBP2 type	0.0493	0.352	0.3519
Brugia malayi	hypothetical protein	0.0025	0.0124	0.0124
Entamoeba histolytica	zinc finger domain containing protein	0.0025	0.0124	0.0481
Echinococcus granulosus	Nuclear pore complex protein Nup153	0.0493	0.352	0.3519
Plasmodium falciparum	RING zinc finger protein, putative	0.0025	0.0124	0.0064
Echinococcus granulosus	sterol regulatory element binding protein	0.0039	0.0223	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0493	0.352	0.3519
Loa Loa (eye worm)	hypothetical protein	0.0048	0.0287	0.0286
Giardia lamblia	Hypothetical protein	0.0025	0.0124	0.5
Plasmodium vivax	aspartyl proteinase, putative	0.0017	0.0064	0.0005
Giardia lamblia	Protein 21.1	0.0025	0.0124	0.5
Brugia malayi	Neuralized family protein	0.0025	0.0124	0.0124
Giardia lamblia	Kinase	0.0025	0.0124	0.5
Onchocerca volvulus	Matrix metalloproteinase homolog	0.004	0.0231	0.0168
Giardia lamblia	Hypothetical protein	0.0025	0.0124	0.5
Toxoplasma gondii	DNA topoisomerase domain-containing protein	0.1387	1	1
Plasmodium falciparum	E3 ubiquitin-protein ligase RNF5, putative	0.0025	0.0124	0.0064
Mycobacterium leprae	PROBABLE HYDROLASE	0.0022	0.0101	1
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0124	0.0123
Schistosoma mansoni	survival motor neuron protein	0.0044	0.0263	0.02
Trypanosoma cruzi	Zn-finger in Ran binding protein and others, putative	0.0493	0.352	1
Entamoeba histolytica	zinc finger domain containing protein	0.0025	0.0124	0.0481
Toxoplasma gondii	zinc finger, C3HC4 type (RING finger) domain-containing protein	0.0025	0.0124	0.006
Echinococcus granulosus	adam 17 protease	0.0024	0.0114	0.0113
Brugia malayi	AMP-binding enzyme family protein	0.0022	0.01	0.01
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.1387	1	1
Echinococcus granulosus	matrix metallopeptidase 7 M10 family	0.0065	0.0416	0.0416
Leishmania major	hypothetical protein, conserved	0.0025	0.0124	0.007
Echinococcus multilocularis	adam	0.0041	0.0242	0.0241
Brugia malayi	Hemopexin family protein	0.0026	0.0127	0.0127
Loa Loa (eye worm)	aspartic protease BmAsp-1	0.0017	0.0064	0.0064
Giardia lamblia	Ser/Thr protein kinase	0.0025	0.0124	0.5
Toxoplasma gondii	SWIB/MDM2 domain-containing protein	0.1387	1	1
Plasmodium vivax	aspartyl protease, putative	0.0017	0.0064	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0072	0.0071
Entamoeba histolytica	zinc finger domain containing protein	0.0025	0.0124	0.0481
Onchocerca volvulus		0.0025	0.0124	0.006
Leishmania major	hypothetical protein, conserved	0.0025	0.0124	0.007
Trichomonas vaginalis	conserved hypothetical protein	0.0039	0.0223	0.016
Giardia lamblia	Protein 21.1	0.0025	0.0124	0.5
Mycobacterium ulcerans	hydrolase	0.0022	0.0101	0.1428
Onchocerca volvulus		0.0025	0.0124	0.006
Loa Loa (eye worm)	hypothetical protein	0.0493	0.352	0.3519
Schistosoma mansoni	hypothetical protein	0.1387	1	1
Schistosoma mansoni	hypothetical protein	0.1387	1	1
Toxoplasma gondii	Zn-finger in Ran binding protein and others domain-containing protein	0.0493	0.352	0.3478
Leishmania major	hypothetical protein, conserved	0.0025	0.0124	0.007
Trypanosoma cruzi	WLM domain containing protein, putative	0.0493	0.352	1
Plasmodium falciparum	zinc finger Ran-binding domain-containing protein 2, putative	0.0493	0.352	0.3481
Leishmania major	hypothetical protein, conserved	0.0025	0.0124	0.007
Plasmodium vivax	aspartyl proteinase, putative	0.0017	0.0064	0.0005
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0072	0.0071
Onchocerca volvulus		0.0493	0.352	0.3478
Toxoplasma gondii	ran binding protein	0.0493	0.352	0.3478
Toxoplasma gondii	aldehyde dehydrogenase	0.0056	0.0346	0.0284
Giardia lamblia	Hypothetical protein	0.0025	0.0124	0.5
Brugia malayi	RING finger protein 20	0.0025	0.0124	0.0124
Leishmania major	hypothetical protein, conserved	0.0025	0.0124	0.007
Leishmania major	hypothetical protein, conserved	0.0025	0.0124	0.007
Echinococcus granulosus	cell growth regulator with ring finger domain	0.0025	0.0124	0.0123
Loa Loa (eye worm)	matrixin family protein	0.0044	0.0257	0.0257
Echinococcus granulosus	cathepsin d lysosomal aspartyl protease	0.0017	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0064	0.0064
Onchocerca volvulus		0.1387	1	1
Echinococcus granulosus	SWI:SNF matrix associated	0.1387	1	1
Mycobacterium ulcerans	acyl-CoA synthetase	0.0022	0.01	0.1394
Mycobacterium ulcerans	hypothetical protein	0.0022	0.01	0.1394
Plasmodium vivax	aspartyl protease, putative	0.0017	0.0064	0.0005
Plasmodium vivax	DNA repair protein RAD5, putative	0.0025	0.0124	0.0064
Giardia lamblia	Protein 21.1	0.0025	0.0124	0.5
Brugia malayi	ADAM-TS Spacer 1 family protein	0.0018	0.007	0.007
Brugia malayi	Matrixin family protein	0.0018	0.0072	0.0072
Giardia lamblia	Protein 21.1	0.0025	0.0124	0.5
Leishmania major	hypothetical protein, conserved	0.0493	0.352	1
Entamoeba histolytica	zinc finger domain containing protein	0.0025	0.0124	0.0481
Echinococcus multilocularis	RING finger protein 185	0.0025	0.0124	0.0123
Mycobacterium tuberculosis	Probable peptidoglycan hydrolase	0.0022	0.0101	0.1616
Giardia lamblia	Ribonuclease	0.0025	0.0124	0.5
Brugia malayi	YY1-associated factor 2	0.0493	0.352	0.352
Loa Loa (eye worm)	matrix metalloproteinase	0.0018	0.0072	0.0071
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Leishmania major	DNA repair protein-like protein	0.0025	0.0124	0.007
Echinococcus multilocularis	microtubule associated protein 2	0.0635	0.4543	0.4543
Onchocerca volvulus	Putative RING finger protein 207	0.0025	0.0124	0.006
Plasmodium falciparum	plasmepsin V	0.0017	0.0064	0.0005
Entamoeba histolytica	zinc finger domain containing protein	0.0025	0.0124	0.0481
Echinococcus granulosus	Niemann Pick C1 protein	0.0091	0.0598	0.0597
Trypanosoma brucei	hypothetical protein, conserved	0.0493	0.352	1
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0493	0.352	1
Plasmodium falciparum	plasmepsin III	0.0017	0.0064	0.0005
Schistosoma mansoni	zinc finger protein	0.0025	0.0124	0.006
Schistosoma mansoni	matrix metallopeptidase-7 (M10 family)	0.0018	0.0072	0.0008
Brugia malayi	Disintegrin family protein	0.0087	0.0574	0.0574
Echinococcus multilocularis	RING finger and transmembrane domain containing protein	0.0025	0.0124	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0022	0.01	0.0099
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Loa Loa (eye worm)	hypothetical protein	0.0091	0.0598	0.0597
Echinococcus granulosus	microtubule associated protein 2	0.0635	0.4543	0.4543
Schistosoma mansoni	hypothetical protein	0.0037	0.0213	0.015
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0025	0.0124	0.006
Onchocerca volvulus		0.0026	0.0127	0.0063
Loa Loa (eye worm)	matrixin family protein	0.004	0.0231	0.023
Echinococcus multilocularis		0.0025	0.0124	0.0123
Echinococcus multilocularis	E3 ubiquitin protein ligase MYLIP	0.0025	0.0124	0.0123
Mycobacterium ulcerans	fatty-acid-CoA ligase	0.0022	0.01	0.1394
Leishmania major	hypothetical protein, conserved	0.0493	0.352	1
Echinococcus multilocularis	dnaJ subfamily B	0.0376	0.2669	0.2668
Brugia malayi	B-box zinc finger family protein	0.0025	0.0124	0.0124
Loa Loa (eye worm)	aspartyl protease 6	0.0017	0.0064	0.0064
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Brugia malayi	RING zinc finger protein	0.0025	0.0124	0.0124
Echinococcus granulosus	survival motor neuron protein 1	0.0217	0.1518	0.1518
Echinococcus multilocularis	Niemann Pick C1 protein	0.0129	0.088	0.0879
Echinococcus multilocularis	SWI:SNF matrix associated	0.1387	1	1
Echinococcus multilocularis	cpg binding protein	0.0028	0.0144	0.0143
Brugia malayi	hypothetical protein	0.0041	0.0242	0.0242
Schistosoma mansoni	subfamily M12B unassigned peptidase (M12 family)	0.0024	0.0114	0.005
Echinococcus granulosus	ring finger protein 113a	0.0025	0.0124	0.0123
Echinococcus granulosus	RING finger and transmembrane domain containing protein	0.0025	0.0124	0.0123
Toxoplasma gondii	Bardet-Biedl syndrome 5, putative	0.0025	0.0124	0.006
Echinococcus granulosus	RING finger protein 185	0.0025	0.0124	0.0123
Schistosoma mansoni	aldehyde dehydrogenase	0.0056	0.0346	0.0284
Onchocerca volvulus		0.0493	0.352	0.3478
Loa Loa (eye worm)	CXXC zinc finger family protein	0.0026	0.0133	0.0132
Plasmodium falciparum	E3 ubiquitin-protein ligase, putative	0.0025	0.0124	0.0064
Echinococcus granulosus	E3 ubiquitin protein ligase LRSAM1	0.0025	0.0124	0.0123
Echinococcus granulosus	E3 ubiquitin protein ligase RNF146	0.0025	0.0124	0.0123
Brugia malayi	hypothetical protein	0.0025	0.0124	0.0124
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0064	0.0064
Toxoplasma gondii	SWI2/SNF2-containing protein RAD5	0.0025	0.0124	0.006
Loa Loa (eye worm)	hypothetical protein	0.0017	0.0064	0.0064
Schistosoma mansoni	hypothetical protein	0.1387	1	1
Echinococcus multilocularis	E3 ubiquitin protein ligase LRSAM1	0.0025	0.0124	0.0123
Giardia lamblia	Protein 21.1	0.0025	0.0124	0.5
Trichomonas vaginalis	ion channel nompc, putative	0.0025	0.0124	0.006
Mycobacterium ulcerans	long-chain-fatty-acid-CoA ligase	0.0022	0.01	0.1394
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0124	0.0123
Brugia malayi	hypothetical protein	0.0217	0.1518	0.1518
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0025	0.0124	0.006
Echinococcus granulosus	Blood coagulation inhibitor Disintegrin	0.0058	0.0363	0.0362
Brugia malayi	aspartic protease BmAsp-1, identical	0.0017	0.0064	0.0064
Echinococcus multilocularis	SWI:SNF matrix associated	0.1387	1	1
Schistosoma mansoni	cpg binding protein	0.0028	0.0144	0.008
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Schistosoma mansoni	memapsin-2 (A01 family)	0.0422	0.3	0.2954
Mycobacterium tuberculosis	Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase)	0.0016	0.006	0.022
Schistosoma mansoni	rnf5	0.0025	0.0124	0.006
Entamoeba histolytica	SPRY domain protein	0.0025	0.0124	0.0481
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Loa Loa (eye worm)	hypothetical protein	0.0022	0.01	0.0099
Brugia malayi	hypothetical protein	0.0025	0.0124	0.0124
Schistosoma mansoni	subfamily M12B unassigned peptidase (M12 family)	0.0024	0.0114	0.005
Plasmodium falciparum	trophozoite exported protein 1	0.0025	0.0124	0.0064
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Giardia lamblia	Hypothetical protein	0.0025	0.0124	0.5
Chlamydia trachomatis	DNA topoisomerase I	0.1387	1	1
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0746	0.5349	0.5348
Mycobacterium ulcerans	long-chain-fatty-acid--CoA ligase	0.0022	0.01	0.1394
Trypanosoma cruzi	mitochondrial RNA binding complex 1 subunit, putative	0.0493	0.352	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0056	0.0346	1
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0493	0.352	0.352
Schistosoma mansoni	hypothetical protein	0.0026	0.0127	0.0063
Onchocerca volvulus	Matrilysin homolog	0.004	0.0231	0.0168
Onchocerca volvulus		0.0025	0.0124	0.006
Onchocerca volvulus		0.0022	0.01	0.0036
Giardia lamblia	E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B	0.0025	0.0124	0.5
Toxoplasma gondii	hypothetical protein	0.0025	0.0124	0.006
Brugia malayi	CXXC zinc finger family protein	0.0026	0.0133	0.0133
Schistosoma mansoni	cpg binding protein	0.0028	0.0144	0.008
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Schistosoma mansoni	ring finger protein 151	0.0025	0.0124	0.006
Echinococcus multilocularis	cathepsin d (lysosomal aspartyl protease)	0.0017	0.0064	0.0064
Loa Loa (eye worm)	hypothetical protein	0.0018	0.007	0.0069
Onchocerca volvulus		0.0025	0.0124	0.006
Loa Loa (eye worm)	hypothetical protein	0.0016	0.006	0.0059
Loa Loa (eye worm)	hypothetical protein	0.0018	0.007	0.0069
Brugia malayi	AMP-binding enzyme family protein	0.0022	0.01	0.01
Trichomonas vaginalis	sex-determining protein fem-1, putative	0.0025	0.0124	0.006
Brugia malayi	brahma associated protein 60 kDa	0.1387	1	1
Trichomonas vaginalis	ankyrin repeat domain protein, putative	0.0025	0.0124	0.006
Plasmodium vivax	hypothetical protein, conserved	0.1387	1	1
Schistosoma mansoni	hypothetical protein	0.0376	0.2669	0.2621
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Trypanosoma cruzi	WLM domain containing protein, putative	0.0493	0.352	1
Giardia lamblia	Protein 21.1	0.0025	0.0124	0.5
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0124	0.0123
Trichomonas vaginalis	ubiquitin-protein ligase BRE1, putative	0.0025	0.0124	0.006
Plasmodium vivax	E3 ubiquitin-protein ligase, putative	0.0025	0.0124	0.0064
Giardia lamblia	Zinc finger domain	0.0025	0.0124	0.5
Echinococcus multilocularis	SWI:SNF matrix associated	0.1387	1	1
Onchocerca volvulus	Matrilysin homolog	0.0018	0.0072	0.0008
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0025	0.0124	0.006
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Schistosoma mansoni	dihydroceramide desaturase	0.0087	0.0574	0.0513
Giardia lamblia	Protein 21.1	0.0025	0.0124	0.5
Loa Loa (eye worm)	brahma associated protein	0.1387	1	1
Giardia lamblia	Protein 21.1	0.0025	0.0124	0.5
Brugia malayi	hypothetical protein	0.0025	0.0124	0.0124
Echinococcus multilocularis	Nuclear pore complex protein Nup153	0.0493	0.352	0.3519
Schistosoma mansoni	matrix metallopeptidase-9 (M10 family)	0.0043	0.0252	0.0189
Leishmania major	hypothetical protein, conserved	0.0025	0.0124	0.007
Trypanosoma cruzi	hypothetical protein, conserved	0.0493	0.352	1
Schistosoma mansoni	peter pan-related	0.0025	0.0124	0.006
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Brugia malayi	Pepsin A precursor	0.0017	0.0064	0.0064
Entamoeba histolytica	zinc finger domain containing protein	0.0025	0.0124	0.0481
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Loa Loa (eye worm)	hypothetical protein	0.0058	0.0363	0.0362
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0056	0.0346	0.0722
Giardia lamblia	Protein 21.1	0.0025	0.0124	0.5
Loa Loa (eye worm)	RiNg Finger protein family member	0.0025	0.0124	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0124	0.0123
Echinococcus granulosus	zinc finger protein Ran binding	0.0493	0.352	0.3519
Loa Loa (eye worm)	aspartic protease BmAsp-2	0.0017	0.0064	0.0064
Echinococcus granulosus	E3 ubiquitin protein ligase Bre1	0.0025	0.0124	0.0123
Schistosoma mansoni	hypothetical protein	0.0025	0.0124	0.006
Brugia malayi	hypothetical protein	0.0017	0.0064	0.0064
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0039	0.0223	0.0222
Brugia malayi	aspartic protease BmAsp-2, identical	0.0017	0.0064	0.0064
Brugia malayi	Matrix metalloprotease, N-terminal domain containing protein	0.0022	0.0101	0.0101
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Leishmania major	hypothetical protein, conserved	0.0025	0.0124	0.007
Leishmania major	hypothetical protein, unknown function	0.0025	0.0124	0.007
Echinococcus multilocularis	disintegrin and metalloproteinase	0.0087	0.0574	0.0574
Onchocerca volvulus	Ubiquitin thioesterase ZRANB1 homolog	0.0493	0.352	0.3478
Plasmodium falciparum	plasmepsin VIII, putative	0.0017	0.0064	0.0005
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0056	0.0346	1
Loa Loa (eye worm)	hypothetical protein	0.0022	0.0101	0.01
Schistosoma mansoni	TRABID protein (C64 family)	0.0493	0.352	0.3478
Echinococcus granulosus	disintegrin and metalloproteinase	0.0087	0.0574	0.0574
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0124	0.0123
Schistosoma mansoni	hypothetical protein	0.0037	0.0213	0.015
Mycobacterium ulcerans	acyl-CoA synthetase	0.0022	0.01	0.1394
Echinococcus granulosus	subfamily M12B unassigned peptidase	0.0024	0.0114	0.0113
Trichomonas vaginalis	hypothetical protein	0.0025	0.0124	0.006
Leishmania major	hypothetical protein, conserved	0.0025	0.0124	0.007
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Plasmodium falciparum	SWIB/MDM2 domain-containing protein	0.1387	1	1
Schistosoma mansoni	hypothetical protein	0.0493	0.352	0.3478
Brugia malayi	ADAMTS-like protease	0.0018	0.007	0.007
Trichomonas vaginalis	cell cycle control protein cwf24, putative	0.0025	0.0124	0.006
Giardia lamblia	Protein 21.1	0.0025	0.0124	0.5
Onchocerca volvulus		0.0025	0.0124	0.006
Echinococcus multilocularis	ring and YY1 binding protein	0.0493	0.352	0.3519
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Brugia malayi	Zinc finger protein 183 homolog	0.0025	0.0124	0.0124
Echinococcus multilocularis	matrix metallopeptidase 7 (M10 family)	0.0065	0.0416	0.0416
Giardia lamblia	Protein 21.1	0.0025	0.0124	0.5
Giardia lamblia	Protein 21.1	0.0025	0.0124	0.5
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0072	0.0071
Plasmodium falciparum	plasmepsin X	0.0017	0.0064	0.0005
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Plasmodium vivax	E3 ubiquitin-protein ligase RNF5, putative	0.0025	0.0124	0.0064
Leishmania major	hypothetical protein, conserved	0.0493	0.352	1
Plasmodium falciparum	plasmepsin IX	0.0017	0.0064	0.0005
Loa Loa (eye worm)	hypothetical protein	0.0022	0.01	0.0099
Onchocerca volvulus		0.0025	0.0124	0.006
Plasmodium vivax	trophozoite exported protein 1, putative	0.0025	0.0124	0.0064
Leishmania major	hypothetical protein, conserved	0.0025	0.0124	0.007
Plasmodium vivax	RING zinc finger protein, putative	0.0025	0.0124	0.0064
Giardia lamblia	Hypothetical protein	0.0025	0.0124	0.5
Toxoplasma gondii	histone lysine methyltransferase SET1	0.005	0.0304	0.0242
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0493	0.352	0.352
Giardia lamblia	Protein 21.1	0.0025	0.0124	0.5
Schistosoma mansoni	microtubule-associated protein tau	0.0635	0.4543	0.4508
Giardia lamblia	Protein 21.1	0.0025	0.0124	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Brugia malayi	Zinc finger, C2H2 type family protein	0.0025	0.0124	0.0124
Trypanosoma brucei	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0493	0.352	1
Plasmodium falciparum	plasmepsin VII	0.0017	0.0064	0.0005
Loa Loa (eye worm)	RING finger protein 20	0.0025	0.0124	0.0123
Schistosoma mansoni	hypothetical protein	0.0025	0.0124	0.006
Schistosoma mansoni	mind bomb	0.0025	0.0124	0.006
Schistosoma mansoni	brg-1 associated factor	0.1387	1	1
Trichomonas vaginalis	ankyrin, putative	0.0025	0.0124	0.006
Echinococcus granulosus	Upstream activation factor subunit UAF30	0.1387	1	1
Onchocerca volvulus		0.0493	0.352	0.3478
Echinococcus multilocularis	protein dispatched 1	0.0044	0.0263	0.0262
Echinococcus granulosus	adam	0.0041	0.0242	0.0241
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Chlamydia trachomatis	SWIB complex protein	0.1387	1	1
Echinococcus multilocularis	E3 ubiquitin protein ligase Bre1	0.0025	0.0124	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0124	0.0123
Plasmodium vivax	aspartyl protease, putative	0.0017	0.0064	0.0005
Trichomonas vaginalis	ankyrin 2,3/unc44, putative	0.0025	0.0124	0.006
Echinococcus multilocularis	Niemann Pick C1 protein	0.0091	0.0598	0.0597
Loa Loa (eye worm)	hypothetical protein	0.0493	0.352	0.3519
Brugia malayi	hypothetical protein	0.0017	0.0064	0.0064
Schistosoma mansoni	RNA binding protein	0.0493	0.352	0.3478
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Brugia malayi	Zn-finger in Ran binding protein and others containing protein	0.0493	0.352	0.352
Loa Loa (eye worm)	hypothetical protein	0.0016	0.006	0.0059
Entamoeba histolytica	zinc finger domain containing protein	0.0025	0.0124	0.0481
Echinococcus multilocularis	ring finger protein 113a	0.0025	0.0124	0.0123
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Giardia lamblia	Kinase, NEK	0.0025	0.0124	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Leishmania major	hypothetical protein, conserved	0.0493	0.352	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0493	0.352	1
Schistosoma mansoni	zinc finger protein	0.0493	0.352	0.3478
Brugia malayi	angiogenesis inhibito	0.0018	0.007	0.007
Giardia lamblia	Kinase, NEK	0.0025	0.0124	0.5
Brugia malayi	Matrixin family protein	0.0018	0.0072	0.0072
Giardia lamblia	Protein 21.1	0.0025	0.0124	0.5
Brugia malayi	SWIB/MDM2 domain containing protein	0.1387	1	1
Mycobacterium tuberculosis	Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase)	0.0022	0.01	0.1583
Echinococcus multilocularis	E3 ubiquitin protein ligase mib1	0.0025	0.0124	0.0123
Plasmodium falciparum	zinc finger protein, putative	0.0025	0.0124	0.0064
Plasmodium falciparum	plasmepsin VI	0.0017	0.0064	0.0005
Brugia malayi	Matrixin family protein	0.0018	0.0072	0.0072
Trypanosoma cruzi	Zn-finger in Ran binding protein and others/FYVE zinc finger, putative	0.0493	0.352	1
Mycobacterium ulcerans	long-chain fatty-acid CoA ligase	0.0022	0.01	0.1394
Leishmania major	hypothetical protein	0.0025	0.0124	0.007
Trichomonas vaginalis	ankyrin, putative	0.0025	0.0124	0.006
Mycobacterium tuberculosis	Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase)	0.0022	0.01	0.1583
Schistosoma mansoni	hypothetical protein	0.0037	0.0213	0.015
Loa Loa (eye worm)	hypothetical protein	0.0018	0.007	0.0069
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0056	0.0346	0.0346
Echinococcus granulosus	ring and YY1 binding protein	0.0493	0.352	0.3519
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0124	0.0123
Leishmania major	hypothetical protein, conserved	0.0025	0.0124	0.007
Brugia malayi	Niemann-Pick C1 protein precursor	0.0091	0.0598	0.0598
Schistosoma mansoni	aldehyde dehydrogenase	0.0056	0.0346	0.0284
Loa Loa (eye worm)	SWIB/MDM2 domain-containing protein	0.1387	1	1
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0056	0.0346	0.0346
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0025	0.0124	0.006
Brugia malayi	Matrixin family protein	0.0044	0.0257	0.0257
Schistosoma mansoni	hypothetical protein	0.0037	0.0213	0.015
Echinococcus granulosus	Protein patched homolog 1	0.0039	0.0223	0.0222
Loa Loa (eye worm)	hypothetical protein	0.0016	0.006	0.0059
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0044	0.0263	0.0263
Leishmania major	hypothetical protein, conserved	0.0025	0.0124	0.007
Schistosoma mansoni	mixed-lineage leukemia protein mll	0.0056	0.0348	0.0285
Entamoeba histolytica	hypothetical protein	0.0025	0.0124	0.0481
Schistosoma mansoni	inhibitor of apoptosis 1 diap1	0.0025	0.0124	0.006
Loa Loa (eye worm)	hypothetical protein	0.0493	0.352	0.3519
Brugia malayi	hypothetical protein	0.0025	0.0124	0.0124
Giardia lamblia	Protein 21.1	0.0025	0.0124	0.5
Echinococcus multilocularis	expressed conserved protein	0.0085	0.0558	0.0557
Schistosoma mansoni	fusion	0.0493	0.352	0.3478
Giardia lamblia	Protein 21.1	0.0025	0.0124	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0025	0.0124	0.006
Toxoplasma gondii	RING zinc finger protein	0.0025	0.0124	0.006
Plasmodium vivax	SWIB/MDM2 domain-containing protein, putative	0.1387	1	1
Schistosoma mansoni	hypothetical protein	0.0044	0.0263	0.02
Giardia lamblia	Protein 21.1	0.0025	0.0124	0.5
Toxoplasma gondii	helicase, putative	0.0025	0.0124	0.006

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL1689072

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1495734