Detailed information for compound 1504502

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 494.897 | Formula: C22H22ClF3N6O2
  • H donors: 2 H acceptors: 4 LogP: 1.38 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N[C@H](Cc1cc(F)c(cc1F)F)CC(=O)N1CCn2c(C1)c(nn2)c1ccc(cc1)C(=O)N.Cl
  • InChi: 1S/C22H21F3N6O2.ClH/c23-16-10-18(25)17(24)8-14(16)7-15(26)9-20(32)30-5-6-31-19(11-30)21(28-29-31)12-1-3-13(4-2-12)22(27)33;/h1-4,8,10,15H,5-7,9,11,26H2,(H2,27,33);1H/t15-;/m1./s1
  • InChiKey: BZZZAQIXXZSWLW-XFULWGLBSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens dipeptidyl-peptidase 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) prolyl oligopeptidase Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Candida albicans dipeptidyl aminopeptidase B Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus granulosus dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein Get druggable targets OG5_128614 All targets in OG5_128614
Brugia malayi prolyl oligopeptidase family protein Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma japonicum ko:K01278 dipeptidyl-peptidase 4, putative Get druggable targets OG5_128614 All targets in OG5_128614
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) Get druggable targets OG5_128614 All targets in OG5_128614
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog Get druggable targets OG5_128614 All targets in OG5_128614
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Sugar transporter ERD6 protein 0.0016 0.0017 0.0017
Echinococcus multilocularis flap endonuclease 1 0.0028 0.0102 0.0102
Brugia malayi Flap endonuclease-1 0.0028 0.0102 0.0632
Echinococcus multilocularis pyruvate kinase 0.0035 0.0145 0.0145
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0186 0.0405
Entamoeba histolytica Flap nuclease, putative 0.0028 0.0102 0.0196
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0127 0.0194
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0127 0.0264
Echinococcus granulosus prolyl endopeptidase 0.0017 0.0021 0.0021
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0017 0.0021 0.0008
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.0021 0.0004
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0021 0.005
Mycobacterium ulcerans hypothetical protein 0.0017 0.0025 0.0015
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.0021 0.0004
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.0017 0.0021 0.005
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.006 0.0316 0.2102
Leishmania major pyruvate kinase 0.0035 0.0145 0.1815
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.007 0.0389 0.528
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Schistosoma mansoni lamin 0.0028 0.01 0.0082
Giardia lamblia Flap structure-specific endonuclease 0.0028 0.0102 0.0204
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0131 0.0806 0.2265
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0073 0.0499
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0016 0.0017 0.0017
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0017 0.0021 0.005
Echinococcus multilocularis dna polymerase eta 0.0082 0.0467 0.0467
Loa Loa (eye worm) phosphofructokinase 0.0119 0.0722 0.492
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0118 0.0715 0.2006
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0475 0.6504
Mycobacterium ulcerans penicillin-binding lipoprotein 0.0479 0.3192 0.6345
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0049 0.0444
Loa Loa (eye worm) hypothetical protein 0.0033 0.0131 0.0892
Brugia malayi Pre-SET motif family protein 0.0228 0.1467 1
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0025 0.0105
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0062 0.0333 0.0907
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0018 0.003 0.0013
Schistosoma mansoni pyruvate kinase 0.0018 0.0029 0.0012
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.0021 0.0049 0.0049
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0316 0.0316
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0032 0.0127 0.0157
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0447 0.6097
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0624 0.4182 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0055 0.0286 0.0269
Trichomonas vaginalis DNA helicase recq1, putative 0.0021 0.0049 0.0075
Leishmania major DNA damage repair protein, putative 0.0017 0.0025 0.0105
Schistosoma mansoni pyruvate kinase 0.0035 0.0145 0.0128
Echinococcus multilocularis transcription factor Dp 1 0.004 0.018 0.018
Echinococcus granulosus thioredoxin glutathione reductase 0.0052 0.0261 0.0261
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0028 0.0102 0.1207
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0209 0.1341 0.1341
Treponema pallidum penicillin-binding protein (pbp-3) 0.092 0.6214 1
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0722 0.1691
Schistosoma mansoni DNA helicase recq5 0.0021 0.0049 0.0031
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0029 0.0275
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.0017 0.0021 0.0007
Mycobacterium ulcerans DNA polymerase IV 0.0083 0.0475 0.0916
Leishmania major DNA polymerase eta, putative 0.0082 0.0467 0.6391
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0127 0.2518
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.01 0.0613
Toxoplasma gondii peptidylprolyl isomerase 0.0034 0.014 0.2806
Loa Loa (eye worm) sugar transporter 0.0016 0.0017 0.0118
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0145 0.0307
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0214 0.2798
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0018 0.003 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0475 0.6504
Treponema pallidum fructose-bisphosphate aldolase 0.0624 0.4182 0.6714
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0209 0.1341 0.7951
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0215 0.2811
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0041 0.0341
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0624 0.4182 1
Trypanosoma cruzi oligopeptidase b 0.0017 0.0021 0.005
Onchocerca volvulus 0.0259 0.1682 1
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0722 0.1684
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0035 0.0145 0.0928
Onchocerca volvulus 0.0079 0.0447 0.258
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0131 0.0806 0.2265
Plasmodium falciparum thioredoxin reductase 0.0052 0.0261 0.5593
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0378 0.5122
Onchocerca volvulus 0.0079 0.0447 0.258
Toxoplasma gondii thioredoxin reductase 0.0052 0.0261 0.5593
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0104 0.0209
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.003 0.018
Trypanosoma cruzi DNA polymerase kappa, putative 0.0083 0.0475 0.6504
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.0447 0.0447
Trypanosoma brucei DNA damage repair protein, putative 0.0017 0.0025 0.0105
Trypanosoma brucei DNA polymerase eta, putative 0.0082 0.0467 0.6391
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0305 0.1995 0.5641
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0378 0.5122
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0055 0.0286 0.0286
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0145 0.2928
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0018 0.003 0.0036
Trypanosoma brucei unspecified product 0.0076 0.0428 0.5836
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0145 0.0367
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0475 0.6504
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0305 0.1995 0.3954
Loa Loa (eye worm) hypothetical protein 0.0079 0.0447 0.3046
Brugia malayi intermediate filament protein 0.0028 0.01 0.0613
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0131 0.0114
Giardia lamblia NADH oxidase lateral transfer candidate 0.0018 0.003 0.003
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0118 0.0715 0.2006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0624 0.4182 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0624 0.4182 1
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0722 0.492
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0722 0.1691
Echinococcus granulosus solute carrier family 22 0.0016 0.0017 0.0017
Mycobacterium ulcerans lipase LipD 0.0079 0.0447 0.0858
Trypanosoma brucei DNA polymerase IV, putative 0.0083 0.0475 0.6504
Trypanosoma brucei unspecified product 0.0038 0.0168 0.2143
Plasmodium falciparum glutathione reductase 0.0052 0.0261 0.5593
Loa Loa (eye worm) sugar transporter 0.0016 0.0017 0.0118
Trichomonas vaginalis mercuric reductase, putative 0.0018 0.003 0.003
Mycobacterium leprae PROBABLE BIFUNCTIONAL MEMBRANE-ASSOCIATED PENICILLIN-BINDING PROTEIN 1A/1B PONA2 (MUREIN POLYMERASE) [INCLUDES: PENICILLIN-INSEN 0.0524 0.3498 0.9933
Loa Loa (eye worm) flap endonuclease-1 0.0028 0.0102 0.0698
Loa Loa (eye worm) beta-lactamase 0.0079 0.0447 0.3046
Schistosoma mansoni lamin 0.0028 0.01 0.0082
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.006 0.0316 0.0859
Loa Loa (eye worm) hypothetical protein 0.0035 0.0145 0.0989
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0024 0.0072 0.1247
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.0017 0.0021 0.005
Echinococcus granulosus Solute carrier family 22 5 0.1132 0.7663 0.7663
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0119 0.0722 0.2002
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0018 0.003 0.0025
Echinococcus granulosus chromobox protein 1 0.0073 0.0404 0.0404
Brugia malayi Bloom's syndrome protein homolog 0.0021 0.0049 0.0263
Brugia malayi prolyl oligopeptidase family protein 0.0209 0.1341 0.9137
Echinococcus multilocularis lamin 0.0028 0.01 0.01
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0021 0.0073
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0624 0.4182 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0062 0.0333 0.4479
Leishmania major DNA polymerase eta, putative 0.0044 0.0206 0.2685
Giardia lamblia Alanyl dipeptidyl peptidase 0.0017 0.0021 0.0008
Echinococcus granulosus neuropeptide receptor A26 0.0484 0.3223 0.3223
Echinococcus granulosus pyruvate kinase 0.0035 0.0145 0.0145
Echinococcus multilocularis acylamino acid releasing enzyme 0.0017 0.0021 0.0021
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0018 0.003 0.018
Plasmodium falciparum apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.0454 1
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0016 0.0017 0.0017
Trypanosoma brucei DNA polymerase kappa, putative 0.0062 0.0333 0.4479
Loa Loa (eye worm) hypothetical protein 0.0041 0.0186 0.1266
Brugia malayi hypothetical protein 0.0054 0.0276 0.1822
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0018 0.003 0.029
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0404 0.0929
Schistosoma mansoni DNA polymerase IV / kappa 0.0017 0.0025 0.0007
Leishmania major oligopeptidase b 0.0017 0.0021 0.005
Loa Loa (eye worm) hypothetical protein 0.0079 0.0447 0.3046
Giardia lamblia Fructose-bisphosphate aldolase 0.0624 0.4182 1
Trypanosoma brucei oligopeptidase b 0.0017 0.0021 0.005
Loa Loa (eye worm) intermediate filament protein 0.0028 0.01 0.0679
Echinococcus multilocularis solute carrier family 22 0.0016 0.0017 0.0017
Schistosoma mansoni ap endonuclease 0.002 0.0041 0.0024
Mycobacterium ulcerans epimerase 0.0021 0.0051 0.0067
Entamoeba histolytica deoxycytidyl transferase, putative 0.0055 0.0286 0.0637
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0018 0.003 0.003
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.0017 0.0021 0.005
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0119 0.0722 0.1119
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0041 0.0069
Treponema pallidum penicillin-binding protein (pbp-1) 0.0748 0.5033 0.8091
Loa Loa (eye worm) hypothetical protein 0.0045 0.0214 0.1461
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0145 0.1815
Trypanosoma brucei DNA damage repair protein, putative 0.0017 0.0025 0.0105
Loa Loa (eye worm) hypothetical protein 0.0079 0.0447 0.3046
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0025 0.0105
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.01 0.0679
Mycobacterium tuberculosis Probable peptidase 0.0017 0.0021 0.001
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0447 0.1031
Echinococcus multilocularis lamin dm0 0.0028 0.01 0.01
Brugia malayi Hypothetical 29.7 kDa protein C05D11.5 in chromosome III 0.0021 0.0051 0.028
Toxoplasma gondii exonuclease III APE 0.002 0.0041 0.0551
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0017 0.0021 0.0004
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0447 0.1031
Echinococcus multilocularis solute carrier family 22 0.0016 0.0017 0.0017
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0079 0.0447 0.1234
Schistosoma mansoni hypothetical protein 0.0176 0.1116 0.11
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0131 0.0806 0.2242
Loa Loa (eye worm) hypothetical protein 0.0082 0.0467 0.3187
Echinococcus multilocularis musashi 0.0028 0.01 0.01
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.007 0.0389 0.528
Trichomonas vaginalis rotamase, putative 0.0034 0.014 0.0294
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0722 0.1691
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0228 0.1467 1
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0722 1
Mycobacterium tuberculosis Probable lipase LipE 0.0079 0.0447 0.1234
Leishmania major hypothetical protein, conserved 0.0079 0.0447 0.6097
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0041 0.0058
Schistosoma mansoni DNA polymerase eta 0.0082 0.0467 0.0451
Plasmodium vivax thioredoxin reductase, putative 0.0052 0.0261 0.5593
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0145 0.0256
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0127 0.0264
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0119 0.0722 0.2024
Onchocerca volvulus 0.0032 0.0126 0.065
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0624 0.4182 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0186 0.1012
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0722 0.0706
Mycobacterium ulcerans bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 0.0524 0.3498 0.6956
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0722 0.1684
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0145 0.0926
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0475 0.6504
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0034 0.014 0.174
Loa Loa (eye worm) hypothetical protein 0.008 0.0454 0.3095
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0145 0.0307
Toxoplasma gondii prolyl endopeptidase 0.0017 0.0021 0.0081
Brugia malayi major facilitator superfamily protein 0.0016 0.0017 0.0048
Echinococcus multilocularis dna polymerase kappa 0.0083 0.0475 0.0475
Onchocerca volvulus 0.0045 0.0212 0.1171
Brugia malayi 6-phosphofructokinase 0.0119 0.0722 0.4885
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0447 0.6097
Trypanosoma cruzi DNA damage repair protein, putative 0.0017 0.0025 0.0105
Trypanosoma brucei DNA polymerase IV, putative 0.0076 0.0428 0.5836
Brugia malayi beta-lactamase family protein 0.0079 0.0447 0.2997
Giardia lamblia Pyruvate kinase 0.0035 0.0145 0.0307
Mycobacterium ulcerans hypothetical protein 0.0079 0.0447 0.0858
Schistosoma mansoni terminal deoxycytidyl transferase 0.0055 0.0286 0.0269
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0055 0.0286 0.0286
Mycobacterium ulcerans 6-phosphofructokinase 0.0119 0.0722 0.1408
Echinococcus multilocularis neuropeptide s receptor 0.0484 0.3223 0.3223
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0145 0.2928
Chlamydia trachomatis pyruvate kinase 0.0035 0.0145 0.023
Onchocerca volvulus 0.0079 0.0447 0.258
Trypanosoma cruzi DNA damage repair protein, putative 0.0017 0.0025 0.0105
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.0017 0.0021 0.001
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0049 0.0444
Plasmodium falciparum thioredoxin reductase 0.0018 0.003 0.029
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.0017 0.0021 0.005
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0069 0.0378 0.0378
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.0142
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0624 0.4182 1
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.007 0.0389 0.8518
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.003 0.018
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0131 0.2601
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0316 0.0598
Loa Loa (eye worm) hypothetical protein 0.0079 0.0447 0.3046
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Echinococcus multilocularis bloom syndrome protein 0.0021 0.0049 0.0049
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.003 0.018
Brugia malayi 6-phosphofructokinase 0.0119 0.0722 0.4885
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0069 0.0378 0.2525
Mycobacterium leprae Probable lipase LipE 0.0079 0.0447 0.1217
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0028 0.0102 0.1207
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0215 0.2811
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0016 0.0017 0.0017
Echinococcus multilocularis neuropeptide receptor A26 0.0484 0.3223 0.3223
Mycobacterium leprae Probable penicillin-binding membrane protein PbpB 0.0187 0.1187 0.3332
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0028 0.0102 0.1207
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.003 0.0025
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0041 0.0041
Mycobacterium tuberculosis Probable penicillin-binding protein PbpA 0.0371 0.2448 0.6984
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0041 0.0282
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0018 0.003 0.018
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0049 0.0263
Treponema pallidum hypothetical protein 0.0174 0.11 0.1731
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0475 0.6504
Brugia malayi Pre-SET motif family protein 0.0033 0.0131 0.0828
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0104 0.0209
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.0021 0.0049 0.0716
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0017 0.0118
Mycobacterium ulcerans endonuclease IV 0.008 0.0454 0.0873
Echinococcus granulosus synaptic vesicle 2 protein 0.0016 0.0017 0.0017
Mycobacterium ulcerans penicillin-binding membrane protein PbpB 0.0746 0.502 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.006 0.0316 0.0598
Wolbachia endosymbiont of Brugia malayi cell division protein FtsI 0.0748 0.5033 1
Schistosoma mansoni ap endonuclease 0.002 0.0041 0.0024
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0018 0.003 0.029
Loa Loa (eye worm) hypothetical protein 0.0032 0.0126 0.0856
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0032 0.0127 0.0256
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0017 0.0021 0.005
Entamoeba histolytica exodeoxyribonuclease III, putative 0.002 0.0041 0.0049
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0035 0.0145 0.0992
Brugia malayi hypothetical protein 0.0016 0.0017 0.0048
Onchocerca volvulus 0.0028 0.01 0.0494
Trichomonas vaginalis glutathione reductase, putative 0.0018 0.003 0.003
Mycobacterium ulcerans serine/threonine-protein kinase B PknB 0.0174 0.11 0.2165
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0032 0.0127 0.0264
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0145 0.0768
Trichomonas vaginalis DNA polymerase eta, putative 0.0083 0.0475 0.11
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.002 0.0041 0.0048
Echinococcus granulosus 6 phosphofructokinase 0.0119 0.0722 0.0722
Leishmania major pyruvate kinase 0.0035 0.0145 0.1815
Trichomonas vaginalis conserved hypothetical protein 0.0527 0.3521 0.8413
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0475 0.6504
Echinococcus multilocularis solute carrier family 22 0.0016 0.0017 0.0017
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0447 0.1031
Mycobacterium tuberculosis Probable bifunctional membrane-associated penicillin-binding protein 1A/1B PonA2 (murein polymerase) [includes: penicillin-insen 0.0524 0.3498 1
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.006 0.0316 0.0316
Echinococcus granulosus expressed protein 0.0035 0.0145 0.0145
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0207 0.1139
Loa Loa (eye worm) prolyl oligopeptidase 0.0209 0.1341 0.9143
Mycobacterium ulcerans penicillin-binding protein PbpA 0.0371 0.2448 0.4858
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0145 0.0355
Mycobacterium leprae Probable transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0174 0.11 0.3084
Echinococcus granulosus transcription factor Dp 1 0.004 0.018 0.018
Mycobacterium tuberculosis Possible penicillin-binding lipoprotein 0.0479 0.3192 0.9121
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.007 0.0389 0.528
Chlamydia trachomatis transglycolase/transpeptidase 0.0748 0.5033 1
Echinococcus multilocularis prolyl endopeptidase 0.0017 0.0021 0.0021
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0018 0.003 0.0025
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0017 0.0021 0.0008
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0018 0.003 0.0025
Loa Loa (eye worm) prolyl oligopeptidase 0.0017 0.0021 0.0142
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0118 0.0715 0.1984
Mycobacterium tuberculosis Conserved hypothetical protein 0.0021 0.0051 0.0097
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0017 0.0021 0.0081
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0021 0.0049 0.0444
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0118 0.0715 0.2006
Toxoplasma gondii 6-phosphofructokinase 0.0032 0.0127 0.2518
Leishmania major DNA polymerase kappa, putative 0.0062 0.0333 0.4479
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0034 0.014 0.174
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.007 0.0389 0.528
Mycobacterium tuberculosis Probable dehydrogenase 0.0118 0.0715 0.2006
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.003 0.018
Plasmodium falciparum flap endonuclease 1 0.0028 0.0102 0.1947
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0018 0.003 0.018
Plasmodium vivax SET domain protein, putative 0.0033 0.0131 0.2601
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.003 0.018
Loa Loa (eye worm) RecQ helicase 0.0021 0.0049 0.0331
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.003 0.018
Trypanosoma brucei prolyl endopeptidase 0.0017 0.0021 0.005
Loa Loa (eye worm) major facilitator superfamily transporter 0.0016 0.0017 0.0118
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0447 0.9836
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0029 0.0275
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0624 0.4182 1
Echinococcus granulosus ATP dependent DNA helicase Q5 0.0021 0.0049 0.0049
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0131 0.0114
Mycobacterium tuberculosis Probable oxidoreductase 0.0131 0.0806 0.2265
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.0142
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0056 0.0289 0.1969
Trypanosoma brucei chrX additional, unordered contigs 0.0017 0.0025 0.0105
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0118 0.0715 0.2006
Loa Loa (eye worm) hypothetical protein 0.0021 0.0051 0.0347
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0624 0.4182 1
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0032 0.0127 0.2518
Giardia lamblia Alanyl dipeptidyl peptidase 0.0017 0.0021 0.0008
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.014 0.174
Mycobacterium ulcerans beta-lactamase 0.0079 0.0447 0.0858
Echinococcus multilocularis pyruvate kinase 0.0035 0.0145 0.0145
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0017 0.0025 0.0169
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0119 0.0722 1
Plasmodium falciparum glutathione reductase 0.0018 0.003 0.029
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0145 0.1815
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.001 0.007
Brugia malayi prolyl oligopeptidase family protein 0.007 0.0389 0.2602
Loa Loa (eye worm) heterochromatin protein 1 0.0073 0.0404 0.2756
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0041 0.0041
Plasmodium falciparum peptidase, putative 0.0017 0.0021 0.0081
Toxoplasma gondii endonuclease IV APN 0.008 0.0454 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0018 0.003 0.018
Echinococcus granulosus solute carrier family 22 0.0016 0.0017 0.0017
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0079 0.0447 0.1234
Mycobacterium tuberculosis Transmembrane serine/threonine-protein kinase B PknB (protein kinase B) (STPK B) 0.0174 0.11 0.3112
Schistosoma mansoni intermediate filament proteins 0.0028 0.01 0.0082
Schistosoma mansoni chromobox protein 0.0073 0.0404 0.0388
Echinococcus multilocularis geminin 0.0176 0.1116 0.1116
Echinococcus granulosus geminin 0.0176 0.1116 0.1116
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0475 0.6504
Brugia malayi Sugar transporter family protein 0.0016 0.0017 0.0048
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0083 0.0475 0.11
Toxoplasma gondii NADPH-glutathione reductase 0.0018 0.003 0.029
Schistosoma mansoni rotamase 0.0035 0.0145 0.0128
Mycobacterium tuberculosis Probable lipase LipD 0.0079 0.0447 0.1234
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0029 0.0275
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0447 0.2997
Leishmania major ATP-dependent phosphofructokinase 0.0119 0.0722 1
Trypanosoma cruzi trypanothione reductase, putative 0.0052 0.0261 0.3467
Brugia malayi ImpB/MucB/SamB family protein 0.0055 0.0286 0.1892
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0131 0.0131
Brugia malayi Thioredoxin reductase 0.0052 0.0261 0.1725
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0069 0.0378 0.5122
Mycobacterium tuberculosis Probable reductase 0.0118 0.0715 0.2006
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.003 0.018
Echinococcus granulosus lamin dm0 0.0028 0.01 0.01
Mycobacterium ulcerans bifunctional penicillin-binding protein 1A/1B PonA1 0.0527 0.3521 0.7003
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0447 0.3046
Trichomonas vaginalis chromobox protein, putative 0.0073 0.0404 0.0929
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0041 0.0048
Leishmania major DNA polymerase kappa, putative 0.0017 0.0025 0.0105
Echinococcus granulosus acylamino acid releasing enzyme 0.0017 0.0021 0.0021
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.0447 0.0858
Brugia malayi hypothetical protein 0.0016 0.0017 0.0048
Loa Loa (eye worm) ATP-dependent DNA helicase 0.0021 0.0049 0.0331
Mycobacterium tuberculosis Conserved hypothetical protein 0.0055 0.0286 0.0771
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0018 0.003 0.003
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0018 0.003 0.018
Trypanosoma cruzi trypanothione reductase, putative 0.0018 0.003 0.018
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.0447 0.0858
Echinococcus multilocularis chromobox protein 1 0.0073 0.0404 0.0404
Brugia malayi Sugar transporter family protein 0.0016 0.0017 0.0048
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0034 0.014 0.174
Treponema pallidum penicillin-binding protein (pbp-2) 0.0527 0.3521 0.5646
Onchocerca volvulus Prolyl endopeptidase homolog 0.0017 0.0021 0.0021
Giardia lamblia Pyruvate kinase 0.0018 0.0029 0.0029
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0028 0.0102 0.1947
Echinococcus granulosus lamin 0.0028 0.01 0.01
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0049 0.0716
Echinococcus multilocularis pyruvate kinase 0.0018 0.0029 0.0029
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.007 0.0389 0.0373
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0041 0.0341
Echinococcus granulosus dna polymerase kappa 0.0083 0.0475 0.0475
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.0447 0.0447
Trichomonas vaginalis conserved hypothetical protein 0.0017 0.0021 0.0008
Trichomonas vaginalis flap endonuclease-1, putative 0.0028 0.0102 0.0204
Loa Loa (eye worm) hypothetical protein 0.0024 0.0073 0.0499
Trypanosoma cruzi DNA polymerase kappa, putative 0.0083 0.0475 0.6504
Plasmodium falciparum DNA repair protein REV1, putative 0.0017 0.0025 0.0169
Brugia malayi polk-prov protein 0.0045 0.0214 0.1402
Brugia malayi DNA-(Apurinic or apyrimidinic site) lyase 0.008 0.0454 0.3046
Loa Loa (eye worm) hypothetical protein 0.0054 0.0276 0.1879
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0018 0.003 0.018
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0447 0.043
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0052 0.0261 0.0702
Brugia malayi Sugar transporter family protein 0.0016 0.0017 0.0048
Echinococcus multilocularis Dipeptidyl peptidase 9 0.007 0.0389 0.0389
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0209 0.1341 0.1341
Giardia lamblia DINP protein human, muc B family 0.0062 0.0333 0.0758
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0447 0.1217
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0017 0.0048
Brugia malayi Heterochromatin protein 1 0.0073 0.0404 0.2705
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0073 0.0126
Brugia malayi ImpB/MucB/SamB family protein 0.0082 0.0467 0.3139
Loa Loa (eye worm) hypothetical protein 0.0017 0.0021 0.0142
Plasmodium vivax apurinic/apyrimidinic endonuclease Apn1, putative 0.008 0.0454 1
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0049 0.0716
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0069 0.0378 0.0858
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0021 0.005
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0017 0.0048
Trichomonas vaginalis set domain proteins, putative 0.0259 0.1682 0.3997
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0127 0.0264
Brugia malayi phosphofructokinase 0.0119 0.0722 0.4885
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0017 0.0021 0.0004
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.002 0.0041 0.0058
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0206 0.2685
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0145 0.0768
Mycobacterium tuberculosis Probable hydrolase 0.0079 0.0447 0.1234
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0018 0.003 0.029
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Trypanosoma cruzi prolyl endopeptidase 0.0017 0.0021 0.005
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0018 0.003 0.029
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0127 0.2518
Echinococcus granulosus chromobox protein 1 0.0073 0.0404 0.0404
Schistosoma mansoni pyruvate kinase 0.0035 0.0145 0.0128
Trypanosoma cruzi DNA polymerase kappa, putative 0.0083 0.0475 0.6504
Echinococcus multilocularis expressed protein 0.0035 0.0145 0.0145
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0131 0.0114
Echinococcus granulosus ATP dependent DNA helicase Q1 0.0021 0.0049 0.0049
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0069 0.0378 0.2578
Loa Loa (eye worm) thioredoxin reductase 0.0052 0.0261 0.1783
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0145 0.0989
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0016 0.0017 0.0017
Mycobacterium leprae POSSIBLE PENICILLIN-BINDING LIPOPROTEIN 0.0479 0.3192 0.9059
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0049 0.0716
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.003 0.018
Mycobacterium tuberculosis Conserved protein 0.0079 0.0447 0.1234
Mycobacterium tuberculosis Probable esterase LipL 0.0079 0.0447 0.1234
Echinococcus multilocularis chromobox protein 1 0.0073 0.0404 0.0404
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0032 0.0127 0.2518
Echinococcus granulosus solute carrier family 22 0.0016 0.0017 0.0017
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0016 0.0017 0.0017
Trypanosoma cruzi DNA polymerase eta, putative 0.0082 0.0467 0.6391
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.0021 0.0049 0.0263
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0207 0.0455
Brugia malayi beta-lactamase 0.0079 0.0447 0.2997
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0032 0.0127 0.0264
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0021 0.0073
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0475 0.6504
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.007 0.0389 0.528
Mycobacterium leprae PROBABLE ENDONUCLEASE IV END (ENDODEOXYRIBONUCLEASE IV) (APURINASE) 0.008 0.0454 0.1237
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.0021 0.0049 0.0049
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0131 0.0131
Schistosoma mansoni DNA helicase recq1 0.0021 0.0049 0.0031
Brugia malayi Major Facilitator Superfamily protein 0.0016 0.0017 0.0048
Loa Loa (eye worm) hypothetical protein 0.0079 0.0447 0.3046
Plasmodium vivax hypothetical protein, conserved 0.0017 0.0021 0.0081
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0041 0.0551
Trichomonas vaginalis rotamase, putative 0.0035 0.0145 0.0308
Brugia malayi beta-lactamase family protein 0.0079 0.0447 0.2997
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0016 0.0017 0.0017
Echinococcus granulosus neuropeptide s receptor 0.0484 0.3223 0.3223
Schistosoma mansoni flap endonuclease-1 0.0026 0.0084 0.0066
Echinococcus multilocularis pyruvate kinase 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0028 0.0096 0.0655
Echinococcus granulosus pyruvate kinase 0.0035 0.0145 0.0145
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0031 0.0123 0.0123
Onchocerca volvulus Putative hydroxypyruvate isomerase 0.0021 0.0051 0.0202
Trypanosoma cruzi DNA polymerase kappa, putative 0.0083 0.0475 0.6504
Mycobacterium leprae conserved hypothetical protein 0.0021 0.0051 0.0086
Echinococcus granulosus flap endonuclease 1 0.0028 0.0102 0.0102
Echinococcus granulosus pyruvate kinase 0.0018 0.0029 0.0029
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0145 0.0926
Trichomonas vaginalis phosphofructokinase, putative 0.0119 0.0722 0.1691
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0055 0.0286 0.1948
Plasmodium falciparum pyruvate kinase 0.0035 0.0145 0.2928
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0145 0.0768
Loa Loa (eye worm) glutathione reductase 0.0052 0.0261 0.1783
Trypanosoma cruzi oligopeptidase b 0.0017 0.0021 0.005
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0018 0.003 0.029
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0034 0.014 0.0286
Mycobacterium tuberculosis Probable penicillin-binding membrane protein PbpB 0.0187 0.1187 0.3361
Loa Loa (eye worm) 6-phosphofructokinase 0.0119 0.0722 0.492
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.0186 0.0405
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0018 0.003 0.0025
Mycobacterium leprae Probable penicillin-binding protein PbpA 0.0371 0.2448 0.6934
Mycobacterium tuberculosis Probable bifunctional penicillin-binding protein 1A/1B PonA1 (murein polymerase) (PBP1): penicillin-insensitive transglycosylase 0.0178 0.1124 0.3179
Echinococcus granulosus bloom syndrome protein 0.0021 0.0049 0.0049
Echinococcus granulosus dna polymerase eta 0.0082 0.0467 0.0467
Mycobacterium tuberculosis Probable endonuclease IV End (endodeoxyribonuclease IV) (apurinase) 0.008 0.0454 0.1255
Chlamydia trachomatis transglycolase/transpeptidase 0.0369 0.2435 0.4807
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0016 0.0017 0.0017
Mycobacterium ulcerans DNA polymerase IV 0.0083 0.0475 0.0916
Trypanosoma brucei DNA polymerase kappa, putative 0.0083 0.0475 0.6504
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.006 0.0316 0.4246
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0045 0.0212 0.0195
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0049 0.0075
Echinococcus granulosus Dipeptidyl peptidase 9 0.007 0.0389 0.0389
Entamoeba histolytica recQ family helicase, putative 0.0021 0.0049 0.0067
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0131 0.0131
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.0447 0.6097
Echinococcus multilocularis thioredoxin glutathione reductase 0.0052 0.0261 0.0261
Schistosoma mansoni chromobox protein 0.0073 0.0404 0.0388
Echinococcus granulosus pyruvate kinase 0.0018 0.0029 0.0029
Toxoplasma gondii phosphofructokinase PFKII 0.0032 0.0127 0.2518
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0041 0.0341
Brugia malayi glutathione reductase 0.0052 0.0261 0.1725
Trichomonas vaginalis DNA helicase recq, putative 0.0021 0.0049 0.0075
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0016 0.0017 0.0017
Mycobacterium ulcerans hypothetical protein 0.0021 0.0051 0.0067
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0018 0.003 0.018
Trypanosoma cruzi hypothetical protein, conserved 0.0017 0.0025 0.0105
Onchocerca volvulus 0.0028 0.01 0.0494
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0016 0.0017 0.0017
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0145 0.1815
Brugia malayi chromobox protein homolog 3 0.0041 0.0186 0.1205
Leishmania major trypanothione reductase 0.0052 0.0261 0.3467
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0503 0.3354 0.9588
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0041 0.0551
Echinococcus multilocularis 6 phosphofructokinase 0.0119 0.0722 0.0722
Trichomonas vaginalis esterase, putative 0.0079 0.0447 0.1031
Trichomonas vaginalis ap endonuclease, putative 0.002 0.0041 0.0058
Brugia malayi hypothetical protein 0.0016 0.0017 0.0048
Schistosoma mansoni 6-phosphofructokinase 0.0119 0.0722 0.0706
Plasmodium vivax glutathione reductase, putative 0.0052 0.0261 0.5593
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0447 0.1031
Echinococcus multilocularis pyruvate kinase 0.0018 0.0029 0.0029
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0069 0.0378 0.5122
Echinococcus granulosus intermediate filament protein 0.0028 0.01 0.01
Entamoeba histolytica phosphofructokinase, putative 0.0119 0.0722 0.1684
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0207 0.0455
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0214 0.2798
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0079 0.0447 0.1234
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0041 0.0214
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0018 0.003 0.0135
Trichomonas vaginalis conserved hypothetical protein 0.0035 0.0145 0.0308
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0209 0.1341 0.1326
Mycobacterium tuberculosis Conserved protein 0.0079 0.0447 0.1234
Plasmodium vivax DNA repair protein REV1, putative 0.0017 0.0025 0.0169
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0044 0.0206 0.4331
Toxoplasma gondii ABC1 family protein 0.0079 0.0447 0.9836
Schistosoma mansoni hypothetical protein 0.0176 0.1116 0.11
Echinococcus multilocularis pyruvate kinase 0.0018 0.0029 0.0029
Mycobacterium ulcerans sugar phosphate isomerases/epimerases 0.0021 0.0051 0.0067
Brugia malayi prolyl oligopeptidase family protein 0.0017 0.0021 0.0073
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0041 0.0341
Trypanosoma brucei unspecified product 0.0038 0.0168 0.2143
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0447 0.043
Giardia lamblia DNA damage repair protein 0.0017 0.0025 0.0018
Loa Loa (eye worm) hypothetical protein 0.0021 0.0049 0.0331
Treponema pallidum exodeoxyribonuclease (exoA) 0.002 0.0041 0.0018
Echinococcus multilocularis synaptic vesicle 2 protein 0.0016 0.0017 0.0017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0624 0.4182 1
Chlamydia trachomatis endonuclease IV 0.008 0.0454 0.0847
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0127 0.0264
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0127 0.0264
Echinococcus granulosus solute carrier family 22 0.0016 0.0017 0.0017
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0145 0.0989
Trichomonas vaginalis phosphofructokinase, putative 0.0032 0.0127 0.0264
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.006 0.0316 0.03
Loa Loa (eye worm) hypothetical protein 0.0028 0.01 0.0679
Trypanosoma brucei hypothetical protein, conserved 0.0017 0.0025 0.0105
Giardia lamblia Sgs1 DNA helicase, putative 0.0021 0.0049 0.0075
Mycobacterium tuberculosis Conserved protein 0.0079 0.0447 0.1234
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0447 0.1031
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0215 0.2811
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0032 0.0127 0.0194
Plasmodium vivax flap endonuclease 1, putative 0.0028 0.0102 0.1947
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0145 0.1815
Plasmodium vivax 6-phosphofructokinase, putative 0.0032 0.0127 0.2518
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0305 0.1995 0.5684
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0145 0.0989
Toxoplasma gondii hypothetical protein 0.0017 0.0021 0.0081
Trypanosoma brucei trypanothione reductase 0.0052 0.0261 0.3467
Mycobacterium leprae PROBABLE BIFUNCTIONAL PENICILLIN-BINDING PROTEIN 1A/1B PONA1 (MUREIN POLYMERASE) (PBP1): PENICILLIN-INSENSITIVE TRANSGLYCOSYLASE 0.0527 0.3521 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118
Trypanosoma brucei prolyl oligopeptidase, putative 0.0017 0.0021 0.005
Echinococcus multilocularis solute carrier family 22 0.0016 0.0017 0.0017
Trypanosoma brucei DNA polymerase IV, putative 0.0083 0.0475 0.6504
Brugia malayi major facilitator superfamily protein 0.0016 0.0017 0.0048
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0069 0.0378 0.0378
Echinococcus granulosus pyruvate kinase 0.0018 0.0029 0.0029
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0069 0.0378 0.0361
Loa Loa (eye worm) hypothetical protein 0.0079 0.0447 0.3046
Loa Loa (eye worm) hypothetical protein 0.0016 0.0017 0.0118

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 36.43 nM Inhibition of human DPP4 assessed as hydrolytic reaction of Ala-Pro-AMC ChEMBL. 21334204

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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