Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | amine transporter, putative | 0.004 | 0.0165 | 0.2534 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1193 | 0.8595 | 1 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.0231 | 0.1558 | 0.2097 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0027 | 0.007 | 0.0061 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0019 | 0.001 | 0.001 |
Plasmodium falciparum | cytochrome c oxidase subunit 2, putative | 0.0044 | 0.0193 | 0.0498 |
Brugia malayi | hypothetical protein | 0.004 | 0.0165 | 0.0174 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1279 | 0.134 |
Onchocerca volvulus | 0.004 | 0.0165 | 0.0161 | |
Loa Loa (eye worm) | hypothetical protein | 0.1312 | 0.9468 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.015 | 0.097 | 0.1013 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0039 | 0.0159 | 0.0156 |
Onchocerca volvulus | 0.0236 | 0.16 | 0.1679 | |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0027 | 0.007 | 0.0074 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0027 | 0.007 | 0.0061 |
Loa Loa (eye worm) | notch protein | 0.0193 | 0.1279 | 0.1351 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.0951 | 0.6828 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0125 | 0.0785 | 0.0829 |
Schistosoma mansoni | septate junction protein | 0.0193 | 0.1279 | 0.134 |
Schistosoma mansoni | sodium-dependent amino acid transporter | 0.004 | 0.0165 | 0.0161 |
Entamoeba histolytica | protein kinase, putative | 0.0191 | 0.1267 | 0.1313 |
Schistosoma mansoni | notch | 0.0193 | 0.1279 | 0.134 |
Mycobacterium ulcerans | integral membrane transporter | 0.0032 | 0.0104 | 0.0094 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.016 | 0.0195 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.004 | 0.0165 | 0.0161 |
Brugia malayi | nuclear receptor NHR-88 | 0.0027 | 0.007 | 0.0074 |
Echinococcus multilocularis | sodium:chloride dependent neurotransmitter | 0.004 | 0.0165 | 0.0161 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0193 | 0.1279 | 0.134 |
Schistosoma mansoni | peroxidasin | 0.1312 | 0.9468 | 1 |
Chlamydia trachomatis | Ssodium-dependent amino acid transporter | 0.004 | 0.0165 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.015 | 0.097 | 0.1013 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0027 | 0.007 | 0.0061 |
Trypanosoma cruzi | Voltage-dependent calcium channel subunit, putative | 0.0039 | 0.0159 | 0.0194 |
Brugia malayi | P38 map kinase family protein 2 | 0.0125 | 0.0785 | 0.0829 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0125 | 0.0785 | 0.101 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0193 | 0.1279 | 0.134 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1312 | 0.9468 | 1 |
Brugia malayi | Cadherin domain containing protein | 0.0193 | 0.1279 | 0.1351 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1069 | 0.7684 | 1 |
Entamoeba histolytica | acetyltransferase, putative | 0.0069 | 0.0374 | 0.0254 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0027 | 0.007 | 0.0061 |
Echinococcus granulosus | protein jagged 1 | 0.0193 | 0.1279 | 0.134 |
Echinococcus multilocularis | serotonin transporter | 0.0236 | 0.16 | 0.1679 |
Onchocerca volvulus | 0.0193 | 0.1279 | 0.134 | |
Echinococcus granulosus | neural cadherin | 0.0193 | 0.1279 | 0.134 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1279 | 0.1351 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1069 | 0.7684 | 0.8116 |
Echinococcus granulosus | FTZ F1 alpha | 0.0027 | 0.007 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.1312 | 0.9468 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0027 | 0.007 | 0.0061 |
Echinococcus multilocularis | protein jagged 1 | 0.0193 | 0.1279 | 0.134 |
Plasmodium falciparum | inorganic anion exchanger, inorganic anion antiporter | 0.0032 | 0.0104 | 0.0252 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.004 | 0.0165 | 0.0161 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0115 | 0.0715 | 0.0743 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0191 | 0.1267 | 0.1339 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0125 | 0.0785 | 0.101 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0027 | 0.007 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.1312 | 0.9468 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.16 | 0.169 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1279 | 0.134 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0027 | 0.007 | 0.0061 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1069 | 0.7684 | 0.8116 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1069 | 0.7684 | 1 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0039 | 0.0159 | 0.0155 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.004 | 0.0165 | 0.0161 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1069 | 0.7684 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0027 | 0.007 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1279 | 0.1351 |
Echinococcus multilocularis | nuclear factor of activated T cells 5 | 0.0072 | 0.0398 | 0.0408 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.004 | 0.0165 | 0.0161 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.16 | 0.169 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0165 | 0.0174 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.004 | 0.0165 | 0.0161 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.1083 | 0.1132 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1279 | 0.1351 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0236 | 0.16 | 0.1679 |
Loa Loa (eye worm) | hypothetical protein | 0.1312 | 0.9468 | 1 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.004 | 0.0165 | 0.0161 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0124 | 0.0131 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0027 | 0.007 | 0.0074 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0193 | 0.1279 | 0.134 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1279 | 0.1351 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0027 | 0.007 | 0.0061 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.015 | 0.097 | 0.1013 |
Trichomonas vaginalis | AGC family protein kinase | 0.0191 | 0.1267 | 0.0946 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1279 | 0.134 |
Echinococcus multilocularis | neurogenic locus notch protein | 0.0193 | 0.1279 | 0.134 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.004 | 0.0165 | 0.0172 |
Schistosoma mansoni | cell polarity protein | 0.0193 | 0.1279 | 0.134 |
Echinococcus granulosus | microsomal glutathione S transferase 3 | 0.0109 | 0.0671 | 0.0697 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1279 | 0.1351 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0039 | 0.0159 | 0.0155 |
Wolbachia endosymbiont of Brugia malayi | cytochrome c oxidase, subunit 2 | 0.0146 | 0.0936 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.007 | 0.0074 |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.0236 | 0.16 | 0.5 |
Echinococcus multilocularis | protein jagged 2 | 0.0193 | 0.1279 | 0.134 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.007 | 0.0074 |
Mycobacterium ulcerans | epoxide hydrolase EphA | 0.016 | 0.104 | 0.1031 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1279 | 0.1351 |
Onchocerca volvulus | 0.02 | 0.1332 | 0.1395 | |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0027 | 0.007 | 0.0061 |
Schistosoma mansoni | lipoxygenase | 0.0115 | 0.0715 | 0.0743 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1193 | 0.8595 | 0.8594 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1279 | 0.1351 |
Brugia malayi | EGF-like domain containing protein | 0.0193 | 0.1279 | 0.1351 |
Echinococcus granulosus | peroxidasin | 0.1312 | 0.9468 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1279 | 0.1351 |
Echinococcus granulosus | protein jagged 1 | 0.0193 | 0.1279 | 0.134 |
Schistosoma mansoni | hypothetical protein | 0.0516 | 0.3647 | 0.3844 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0019 | 0.001 | 0.001 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1385 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0516 | 0.3647 | 0.3844 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0027 | 0.007 | 0.0074 |
Schistosoma mansoni | notch | 0.0193 | 0.1279 | 0.134 |
Loa Loa (eye worm) | hypothetical protein | 0.0516 | 0.3647 | 0.3852 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0027 | 0.007 | 0.0074 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0027 | 0.007 | 0.0074 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1069 | 0.7684 | 0.8114 |
Onchocerca volvulus | 0.1312 | 0.9468 | 1 | |
Brugia malayi | Cadherin domain containing protein | 0.0193 | 0.1279 | 0.1351 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0027 | 0.007 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1279 | 0.1351 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1279 | 0.1351 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0125 | 0.0785 | 0.0817 |
Echinococcus multilocularis | microsomal glutathione S transferase 3 | 0.0109 | 0.0671 | 0.0697 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0027 | 0.007 | 0.0074 |
Echinococcus multilocularis | fat cadherin tumor suppressor | 0.0193 | 0.1279 | 0.134 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0027 | 0.007 | 0.0061 |
Onchocerca volvulus | 0.004 | 0.0165 | 0.0161 | |
Brugia malayi | EGF-like domain containing protein | 0.0193 | 0.1279 | 0.1351 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1069 | 0.7684 | 0.8116 |
Loa Loa (eye worm) | hypothetical protein | 0.1312 | 0.9468 | 1 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.004 | 0.0165 | 0.0161 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.004 | 0.0165 | 0.0172 |
Mycobacterium tuberculosis | Probable transmembrane cytochrome C oxidase (subunit II) CtaC | 0.0044 | 0.0193 | 0.005 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1069 | 0.7684 | 0.8114 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0027 | 0.007 | 0.0074 |
Plasmodium falciparum | amino acid transporter, putative | 0.004 | 0.0165 | 0.042 |
Schistosoma mansoni | coup transcription factor | 0.0027 | 0.007 | 0.0061 |
Schistosoma mansoni | notch | 0.0193 | 0.1279 | 0.134 |
Brugia malayi | notch-like transmembrane receptor | 0.0193 | 0.1279 | 0.1351 |
Echinococcus granulosus | carbonic anhydrase II | 0.1069 | 0.7684 | 0.8114 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0027 | 0.007 | 0.0074 |
Onchocerca volvulus | 0.0066 | 0.0355 | 0.0362 | |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0125 | 0.0785 | 0.0817 |
Echinococcus multilocularis | notch | 0.0193 | 0.1279 | 0.134 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0125 | 0.0785 | 0.0903 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1279 | 0.1351 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0236 | 0.1595 | 0.1685 |
Echinococcus multilocularis | fibropellin Ia | 0.0193 | 0.1279 | 0.134 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.007 | 0.0074 |
Onchocerca volvulus | 0.1312 | 0.9468 | 1 | |
Brugia malayi | EGF-like domain containing protein | 0.0193 | 0.1279 | 0.1351 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0125 | 0.0785 | 0.0817 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0027 | 0.007 | 0.0061 |
Toxoplasma gondii | hypothetical protein | 0.0035 | 0.0124 | 0.0058 |
Onchocerca volvulus | 0.0193 | 0.1279 | 0.134 | |
Brugia malayi | Cytochrome P450 family protein | 0.0019 | 0.001 | 0.001 |
Toxoplasma gondii | hypothetical protein | 0.0516 | 0.3647 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1279 | 0.1351 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1069 | 0.7684 | 0.8116 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.1312 | 0.9468 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0516 | 0.3647 | 0.3852 |
Brugia malayi | EGF-like domain containing protein | 0.0193 | 0.1279 | 0.1351 |
Echinococcus granulosus | geminin | 0.0166 | 0.1083 | 0.1132 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0069 | 0.0374 | 0.2761 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.004 | 0.0165 | 0.0161 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0759 | 0.5423 | 0.7893 |
Echinococcus multilocularis | sodium dependent neurotransmitter transporter | 0.004 | 0.0165 | 0.0161 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0123 | 0.0771 | 0.0803 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0516 | 0.3647 | 0.3844 |
Onchocerca volvulus | Cytochrome c oxidase subunit 2 homolog | 0.0044 | 0.0193 | 0.0191 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0027 | 0.007 | 0.0074 |
Brugia malayi | Transmembrane cell adhesion receptor mua-3 precursor, putative | 0.0193 | 0.1279 | 0.1351 |
Brugia malayi | EGF-like domain containing protein | 0.0193 | 0.1279 | 0.1351 |
Trypanosoma cruzi | Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative | 0.0032 | 0.0104 | 0.0123 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0039 | 0.0159 | 0.0155 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0125 | 0.0785 | 0.101 |
Mycobacterium ulcerans | transmembrane carbonic anhydrase, SulP | 0.0032 | 0.0104 | 0.0094 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0027 | 0.007 | 0.0074 |
Onchocerca volvulus | Peroxidase homolog | 0.1312 | 0.9468 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1312 | 0.9468 | 1 |
Giardia lamblia | High cysteine protein | 0.0193 | 0.1279 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.007 | 0.0074 |
Echinococcus granulosus | neurogenic locus notch protein | 0.0193 | 0.1279 | 0.134 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1279 | 0.1351 |
Onchocerca volvulus | Cytochrome c oxidase subunit 2 homolog | 0.0044 | 0.0193 | 0.0191 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.0236 | 0.16 | 0.169 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0027 | 0.007 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0124 | 0.0131 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.0042 | 0.0181 | 0.0179 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0027 | 0.007 | 0.0074 |
Trichomonas vaginalis | AGC family protein kinase | 0.0191 | 0.1267 | 0.0946 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.007 | 0.0074 |
Onchocerca volvulus | 0.0027 | 0.007 | 0.0061 | |
Brugia malayi | hypothetical protein | 0.0019 | 0.0012 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1279 | 0.1351 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.004 | 0.0165 | 0.0161 |
Mycobacterium tuberculosis | Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) | 0.016 | 0.104 | 0.132 |
Trichomonas vaginalis | AGC family protein kinase | 0.0191 | 0.1267 | 0.0946 |
Loa Loa (eye worm) | voltage-dependent calcium channel | 0.0039 | 0.0159 | 0.0168 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0193 | 0.1279 | 0.1351 |
Loa Loa (eye worm) | calcium channel | 0.0039 | 0.0159 | 0.0168 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0191 | 0.1267 | 0.1339 |
Echinococcus granulosus | delta-like protein 1 | 0.0193 | 0.1279 | 0.134 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.004 | 0.0165 | 0.0161 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1279 | 0.1351 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0027 | 0.007 | 0.0074 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0027 | 0.007 | 0.0061 |
Brugia malayi | phosphoinositide-dependent protein kinase I | 0.0191 | 0.1267 | 0.1339 |
Mycobacterium tuberculosis | Probable serine acetyltransferase CysE (sat) | 0.0069 | 0.0374 | 0.0322 |
Echinococcus multilocularis | protein jagged 1 | 0.0193 | 0.1279 | 0.134 |
Loa Loa (eye worm) | Notch2 | 0.0193 | 0.1279 | 0.1351 |
Plasmodium vivax | cytochrome c oxidase subunit 2, putative | 0.0044 | 0.0193 | 0.3006 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1279 | 0.1351 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.0665 | 0.473 | 0.6855 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0039 | 0.0159 | 0.0155 |
Onchocerca volvulus | Cytochrome c oxidase subunit 2 homolog | 0.0044 | 0.0193 | 0.0191 |
Loa Loa (eye worm) | hypothetical protein | 0.1312 | 0.9468 | 1 |
Schistosoma mansoni | cytochrome-c oxidase | 0.0044 | 0.0193 | 0.0191 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1193 | 0.8595 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0236 | 0.16 | 0.169 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.007 | 0.0074 |
Echinococcus granulosus | carbonic anhydrase | 0.0516 | 0.3647 | 0.3844 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.004 | 0.0165 | 0.0174 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0193 | 0.128 | 0.1341 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0027 | 0.007 | 0.0061 |
Echinococcus multilocularis | carbonic anhydrase | 0.0516 | 0.3647 | 0.3844 |
Loa Loa (eye worm) | Sodium:neurotransmitter symporter family protein | 0.004 | 0.0165 | 0.0174 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0029 | 0.0084 | 0.0088 |
Schistosoma mansoni | notch | 0.0193 | 0.128 | 0.1341 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1385 | 1 | 1 |
Echinococcus granulosus | slit 2 protein | 0.0193 | 0.1279 | 0.134 |
Schistosoma mansoni | carbonic anhydrase | 0.1193 | 0.8595 | 0.9077 |
Echinococcus multilocularis | geminin | 0.0166 | 0.1083 | 0.1132 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0039 | 0.016 | 0.0195 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0193 | 0.1279 | 0.1351 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0193 | 0.1279 | 0.134 |
Brugia malayi | Cytochrome P450 family protein | 0.0019 | 0.001 | 0.001 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0027 | 0.007 | 0.0061 |
Brugia malayi | nuclear hormone receptor | 0.0027 | 0.007 | 0.0074 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1279 | 0.1351 |
Plasmodium falciparum | carbonic anhydrase | 0.0516 | 0.3647 | 1 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0516 | 0.3647 | 0.3844 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0165 | 0.0174 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0027 | 0.007 | 0.0074 |
Brugia malayi | Cytochrome P450 family protein | 0.0029 | 0.0084 | 0.0088 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0039 | 0.0159 | 0.0194 |
Echinococcus granulosus | protein jagged 2 | 0.0193 | 0.1279 | 0.134 |
Brugia malayi | Delta serrate ligand family protein | 0.0193 | 0.1279 | 0.1351 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0027 | 0.007 | 0.0061 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0027 | 0.007 | 0.0061 |
Onchocerca volvulus | Peroxidasin homolog | 0.1312 | 0.9468 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1279 | 0.134 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0039 | 0.0159 | 0.0155 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0012 | 0.0013 |
Plasmodium falciparum | transporter, putative | 0.004 | 0.0165 | 0.042 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0193 | 0.1279 | 0.3317 |
Echinococcus granulosus | sodium and chloride dependent glycine | 0.004 | 0.0165 | 0.0161 |
Echinococcus multilocularis | uncharacterized sodium dependent transporter | 0.004 | 0.0165 | 0.0161 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0193 | 0.1279 | 0.1351 |
Echinococcus granulosus | sodium dependent neurotransmitter transporter | 0.004 | 0.0165 | 0.0161 |
Echinococcus granulosus | neurogenic locus notch protein 4 | 0.0193 | 0.1279 | 0.134 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0027 | 0.007 | 0.0061 |
Echinococcus granulosus | dynactin 5 p25 | 0.0069 | 0.0374 | 0.0383 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.007 | 0.0074 |
Mycobacterium ulcerans | transmembrane carbonic anhydrase, SulP | 0.0032 | 0.0104 | 0.0094 |
Echinococcus granulosus | neurogenic locus protein delta | 0.0193 | 0.1279 | 0.134 |
Trypanosoma brucei | Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative | 0.0032 | 0.0104 | 0.0123 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0039 | 0.0159 | 0.0155 |
Leishmania major | hypothetical protein, conserved | 0.0039 | 0.016 | 0.0175 |
Onchocerca volvulus | Peroxidasin homolog | 0.1312 | 0.9468 | 1 |
Echinococcus granulosus | cytochrome c oxidase subunit II | 0.0146 | 0.0936 | 0.0977 |
Echinococcus granulosus | uncharacterized sodium dependent transporter | 0.004 | 0.0165 | 0.0161 |
Leishmania major | carbonic anhydrase family protein, putative | 0.1193 | 0.8595 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1279 | 0.1351 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.0109 | 0.0671 | 0.0697 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.0236 | 0.16 | 0.1679 |
Brugia malayi | hypothetical protein | 0.0019 | 0.0012 | 0.0013 |
Toxoplasma gondii | MAPEG family protein | 0.0109 | 0.0671 | 0.1602 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0039 | 0.0159 | 0.0155 |
Schistosoma mansoni | notch | 0.0193 | 0.1279 | 0.134 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0193 | 0.1279 | 0.134 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0165 | 0.0174 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1279 | 0.1351 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0027 | 0.007 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0159 | 0.0168 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1279 | 0.134 |
Brugia malayi | GCC2 and GCC3 family protein | 0.0193 | 0.1279 | 0.1351 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1069 | 0.7684 | 0.8114 |
Toxoplasma gondii | hypothetical protein | 0.004 | 0.0165 | 0.0172 |
Brugia malayi | Animal haem peroxidase family protein | 0.1312 | 0.9468 | 1 |
Echinococcus granulosus | notch | 0.0193 | 0.1279 | 0.134 |
Brugia malayi | Peroxidasin | 0.1312 | 0.9468 | 1 |
Brugia malayi | Muscle positioning protein 4 | 0.0193 | 0.1279 | 0.1351 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0165 | 0.0174 |
Echinococcus multilocularis | slit 2 protein | 0.0193 | 0.1279 | 0.134 |
Echinococcus multilocularis | 3 phosphoinositide dependent protein kinase 1 | 0.0191 | 0.1267 | 0.1327 |
Toxoplasma gondii | hypothetical protein | 0.004 | 0.0165 | 0.0172 |
Brugia malayi | steroid hormone receptor | 0.0027 | 0.007 | 0.0074 |
Schistosoma mansoni | sodium/chloride dependent neurotransmitter transporter | 0.004 | 0.0165 | 0.0161 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0165 | 0.2534 |
Brugia malayi | follicle stimulating hormone receptor | 0.0236 | 0.1595 | 0.1685 |
Loa Loa (eye worm) | serotonin transporter b | 0.0236 | 0.16 | 0.169 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1279 | 0.134 |
Schistosoma mansoni | sodium-dependent neurotransmitter transporter | 0.004 | 0.0165 | 0.0161 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.004 | 0.0165 | 0.0174 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.0236 | 0.16 | 0.169 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0027 | 0.007 | 0.0074 |
Onchocerca volvulus | Putative sulfate transporter | 0.02 | 0.1332 | 0.1395 |
Brugia malayi | EGF-like domain containing protein | 0.0193 | 0.1279 | 0.1351 |
Plasmodium vivax | sulfate transporter, putative | 0.0032 | 0.0104 | 0.1523 |
Mycobacterium ulcerans | transmembrane cytochrome C oxidase (subunit II) CtaC | 0.0044 | 0.0193 | 0.0184 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0516 | 0.3647 | 0.3852 |
Loa Loa (eye worm) | cytochrome oxidase subunit 2 | 0.0026 | 0.0064 | 0.0068 |
Onchocerca volvulus | 0.0044 | 0.0193 | 0.0191 | |
Echinococcus granulosus | protein jagged 2 | 0.0193 | 0.1279 | 0.134 |
Brugia malayi | Animal haem peroxidase family protein | 0.1312 | 0.9468 | 1 |
Echinococcus granulosus | nuclear factor of activated T cells 5 | 0.0072 | 0.0398 | 0.0408 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.004 | 0.0165 | 0.0174 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0039 | 0.0159 | 0.0155 |
Brugia malayi | hypothetical protein | 0.1312 | 0.9468 | 1 |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.0478 | 0.3363 | 0.3544 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0115 | 0.0715 | 0.0743 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1312 | 0.9468 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.1312 | 0.9468 | 1 |
Echinococcus granulosus | serotonin transporter | 0.0236 | 0.16 | 0.1679 |
Onchocerca volvulus | 0.1312 | 0.9468 | 1 | |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0027 | 0.007 | 0.0061 |
Onchocerca volvulus | Dual oxidase homolog | 0.1312 | 0.9468 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0027 | 0.007 | 0.0074 |
Echinococcus granulosus | sodium:chloride dependent neurotransmitter | 0.004 | 0.0165 | 0.0161 |
Brugia malayi | Sodium:neurotransmitter symporter family protein 1, putative | 0.004 | 0.0165 | 0.0174 |
Brugia malayi | Blistered cuticle protein 3 | 0.1312 | 0.9468 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1279 | 0.1351 |
Echinococcus granulosus | carbonic anhydrase | 0.0516 | 0.3647 | 0.3844 |
Brugia malayi | Animal haem peroxidase family protein | 0.1312 | 0.9468 | 1 |
Loa Loa (eye worm) | doublecortin family protein | 0.0019 | 0.0012 | 0.0013 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0039 | 0.0159 | 0.0168 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0027 | 0.007 | 0.0061 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0125 | 0.0785 | 0.0817 |
Leishmania major | carbonic anhydrase-like protein | 0.1069 | 0.7684 | 0.8939 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0039 | 0.0159 | 0.0155 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.1279 | 0.134 |
Loa Loa (eye worm) | hypothetical protein | 0.1312 | 0.9468 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0159 | 0.0168 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0027 | 0.007 | 0.0061 |
Loa Loa (eye worm) | hypothetical protein | 0.1312 | 0.9468 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0165 | 0.0174 |
Toxoplasma gondii | Sodium:neurotransmitter symporter family protein | 0.004 | 0.0165 | 0.0172 |
Brugia malayi | Protein kinase domain containing protein | 0.0191 | 0.1267 | 0.1339 |
Brugia malayi | ecdysteroid receptor | 0.0027 | 0.007 | 0.0074 |
Brugia malayi | Doublecortin family protein | 0.0019 | 0.0012 | 0.0013 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0165 | 0.0174 |
Schistosoma mansoni | voltage-gated cation channel | 0.0039 | 0.0159 | 0.0155 |
Schistosoma mansoni | hypothetical protein | 0.0166 | 0.1083 | 0.1132 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0191 | 0.1267 | 0.1327 |
Plasmodium vivax | conserved Plasmodium protein, unknown function | 0.0102 | 0.0614 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1312 | 0.9468 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0516 | 0.3647 | 0.3852 |
Echinococcus multilocularis | neurogenic locus notch protein 4 | 0.0193 | 0.1279 | 0.134 |
Loa Loa (eye worm) | hypothetical protein | 0.1312 | 0.9468 | 1 |
Echinococcus multilocularis | neurogenic locus protein delta | 0.0193 | 0.1279 | 0.134 |
Schistosoma mansoni | hypothetical protein | 0.0123 | 0.0771 | 0.0803 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0039 | 0.0159 | 0.0155 |
Loa Loa (eye worm) | hypothetical protein | 0.1312 | 0.9468 | 1 |
Onchocerca volvulus | 0.004 | 0.0165 | 0.0161 | |
Echinococcus multilocularis | carbonic anhydrase | 0.0516 | 0.3647 | 0.3844 |
Brugia malayi | Sodium:neurotransmitter symporter family protein | 0.004 | 0.0165 | 0.0174 |
Onchocerca volvulus | Slit protein homolog | 0.0193 | 0.1279 | 0.134 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0165 | 0.0174 |
Loa Loa (eye worm) | hypothetical protein | 0.1095 | 0.7876 | 0.8319 |
Schistosoma mansoni | cytochrome c oxidase subunit II | 0.0119 | 0.0743 | 0.0773 |
Schistosoma mansoni | carbonic anhydrase | 0.0516 | 0.3647 | 0.3844 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0516 | 0.3647 | 0.3852 |
Loa Loa (eye worm) | hypothetical protein | 0.1312 | 0.9468 | 1 |
Schistosoma mansoni | notch | 0.0193 | 0.1279 | 0.134 |
Loa Loa (eye worm) | hypothetical protein | 0.1312 | 0.9468 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0012 | 0.0013 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.004 | 0.0165 | 0.0161 |
Toxoplasma gondii | cytochrome C oxidase subunit IIb, putative | 0.0044 | 0.0193 | 0.0252 |
Echinococcus multilocularis | neural cadherin | 0.0193 | 0.1279 | 0.134 |
Schistosoma mansoni | nuclear hormone receptor | 0.0027 | 0.007 | 0.0061 |
Onchocerca volvulus | 0.0193 | 0.1279 | 0.134 | |
Mycobacterium leprae | Probable transmembrane transport protein | 0.0231 | 0.1558 | 0.1751 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0027 | 0.007 | 0.0074 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0516 | 0.3647 | 0.3852 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0027 | 0.007 | 0.0061 |
Entamoeba histolytica | ankyrin, putative | 0.0069 | 0.0375 | 0.0255 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0027 | 0.007 | 0.0061 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0516 | 0.3647 | 0.3852 |
Mycobacterium ulcerans | transferase | 0.0066 | 0.0355 | 0.0345 |
Loa Loa (eye worm) | norepinephrine transporter | 0.0236 | 0.16 | 0.169 |
Onchocerca volvulus | 0.0193 | 0.1279 | 0.134 | |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1279 | 0.1351 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0039 | 0.0159 | 0.0155 |
Brugia malayi | Animal haem peroxidase family protein | 0.1312 | 0.9468 | 1 |
Wolbachia endosymbiont of Brugia malayi | 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase | 0.0069 | 0.0374 | 0.2761 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0039 | 0.0159 | 0.0155 |
Loa Loa (eye worm) | animal heme peroxidase | 0.1312 | 0.9468 | 1 |
Echinococcus multilocularis | peroxidasin | 0.1312 | 0.9468 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.016 | 0.0195 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.1279 | 0.1351 |
Onchocerca volvulus | 0.0193 | 0.1279 | 0.134 | |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0027 | 0.007 | 0.0074 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0027 | 0.007 | 0.0061 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0027 | 0.007 | 0.0074 |
Echinococcus granulosus | carbonic anhydrase | 0.0516 | 0.3647 | 0.3844 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0123 | 0.0771 | 0.0803 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0193 | 0.1279 | 0.134 |
Mycobacterium leprae | PROBABLE TRANSFERASE | 0.0066 | 0.0355 | 0.0341 |
Schistosoma mansoni | slit | 0.0193 | 0.1279 | 0.134 |
Onchocerca volvulus | Putative cubilin | 0.0193 | 0.1279 | 0.134 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.007 | 0.0074 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0027 | 0.007 | 0.0074 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0516 | 0.3647 | 0.3852 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0019 | 0.001 | 0.001 |
Echinococcus granulosus | 3-phosphoinositide-dependent protein kinase 1 | 0.0191 | 0.1267 | 0.1327 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0027 | 0.007 | 0.0061 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.1312 | 0.9468 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.1312 | 0.9468 | 1 |
Brugia malayi | EGF-like domain containing protein | 0.0193 | 0.1279 | 0.1351 |
Echinococcus granulosus | fibropellin Ia | 0.0193 | 0.1279 | 0.134 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0125 | 0.0785 | 0.0817 |
Echinococcus multilocularis | carbonic anhydrase | 0.0516 | 0.3647 | 0.3844 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0027 | 0.007 | 0.0061 |
Schistosoma mansoni | peroxidasin | 0.1312 | 0.9468 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1312 | 0.9468 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0027 | 0.007 | 0.0061 |
Onchocerca volvulus | Cytochrome c oxidase subunit 2 homolog | 0.0044 | 0.0193 | 0.0191 |
Mycobacterium ulcerans | hypothetical protein | 0.0039 | 0.016 | 0.015 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0039 | 0.0159 | 0.0155 |
Schistosoma mansoni | lipoxygenase | 0.0081 | 0.0461 | 0.0474 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0027 | 0.007 | 0.0061 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0125 | 0.0785 | 0.0817 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0027 | 0.007 | 0.0074 |
Trypanosoma cruzi | Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative | 0.0032 | 0.0104 | 0.0123 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0027 | 0.007 | 0.0061 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Average dose (functional) | = 208.9 ug kg-1 | Amount of ouabain needed for production of ventricular extra-systoles at a dose of 2 mg/kg (iv given 5 min prior) in guinea pig | ChEMBL. | 3806567 |
Average dose (functional) | = 325.3 ug kg-1 | Amount of ouabain needed for production of ventricular fibrillation at a dose of 2 mg/kg (iv given 5 min prior) in guinea pig | ChEMBL. | 3806567 |
Average dose (functional) | = 361 ug kg-1 | Amount of ouabain needed for production of ventricular arrhythmias that causes death in guinea pig by cardiac arrest at a dose of 2 mg/kg iv given 5 min prior | ChEMBL. | 3806567 |
ED150 (functional) | = 1.9 mg kg-1 | Effective dose against aconitine-induced arrhythmia after intravenal administration in anesthetized rats | ChEMBL. | 3806567 |
LD50 (ADMET) | = 15 mg kg-1 | Acute toxicity determined after intravenal administration in mice | ChEMBL. | 3806567 |
LD50 (ADMET) | = 15 mg kg-1 | Acute toxicity determined after intravenal administration in mice | ChEMBL. | 3806567 |
No. of positive cases (functional) | = 10 | Incidence of arrhythmias in rats after a intravenal administration at 4mg/kg, expressed as no. of positive cases out of no. of tested cases (10) | ChEMBL. | 3806567 |
Relative potency (functional) | = 6.3 | Relative potency with reference to quinidine | ChEMBL. | 3806567 |
Therapeutic index (ADMET) | = 7.9 | Therapeutic index calculated as the ratio of LD50 in mice to ED 150 in rat when administered intravenously | ChEMBL. | 3806567 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.