TDR Targets

Basic information

Technical information

TDR Targets ID: 1531987
Name: Oprea1_269591
MW: 269.295 | Formula: C16H15NO3
H donors: 0 H acceptors: 2 LogP: 1.08 Rotable bonds: 1
Rule of 5 violations (Lipinski): 1
SMILES: O=C1C2C(C(=O)N1c1ccccc1)C1(OC2(C)C=C1)C
InChi: 1S/C16H15NO3/c1-15-8-9-16(2,20-15)12-11(15)13(18)17(14(12)19)10-6-4-3-5-7-10/h3-9,11-12H,1-2H3
InChiKey: UWPNNSUMYZJALQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	calcium channel, voltage-dependent, N type, alpha 1B subunit	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus multilocularis	voltage dependent calcium channel	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	Muscle calcium channel subunit alpha-1, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	Get druggable targets OG5_126791	All targets in OG5_126791
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Toxoplasma gondii	transporter, cation channel family protein	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma mansoni	voltage-gated cation channel	Get druggable targets OG5_126791	All targets in OG5_126791
Echinococcus granulosus	voltage dependent calcium channel	Get druggable targets OG5_126791	All targets in OG5_126791
Trypanosoma brucei gambiense	calcium channel protein, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	Voltage-dependent calcium channel type D subunit alpha-1, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126791	All targets in OG5_126791
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	Get druggable targets OG5_126791	All targets in OG5_126791
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	Voltage-dependent calcium channel type A subunit alpha-1, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Echinococcus multilocularis	voltage dependent calcium channel	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	Get druggable targets OG5_126791	All targets in OG5_126791
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Echinococcus granulosus	voltage dependent calcium channel	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	ko:K04849 calcium channel, voltage-dependent, N type, alpha 1B subunit, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	ko:K04853 calcium channel, voltage-dependent, L type, alpha 1F subunit, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	Voltage-dependent N-type calcium channel subunit alpha-1B, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	Get druggable targets OG5_126791	All targets in OG5_126791
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126791	All targets in OG5_126791
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	Get druggable targets OG5_126791	All targets in OG5_126791
Trypanosoma congolense	Voltage-dependent calcium channel subunit, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	Get druggable targets OG5_126791	All targets in OG5_126791
Toxoplasma gondii	hypothetical protein	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	Probable voltage-dependent R-type calcium channel subunit alpha-1E, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	ko:K04344 calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	Get druggable targets OG5_126791	All targets in OG5_126791
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_126791	All targets in OG5_126791
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma mansoni	high voltage-activated calcium channel Cav1	Get druggable targets OG5_126791	All targets in OG5_126791
Loa Loa (eye worm)	voltage-dependent calcium channel	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	ko:K04850 calcium channel, voltage-dependent, L type, alpha 1C subunit, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Loa Loa (eye worm)	calcium channel	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Neospora caninum	hypothetical protein	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	Voltage-dependent calcium channel type A subunit alpha-1, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	Voltage-dependent P/Q-type calcium channel subunit alpha-1A, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	Voltage-dependent calcium channel type D subunit alpha-1, putative	Get druggable targets OG5_126791	All targets in OG5_126791
Schistosoma japonicum	expressed protein	Get druggable targets OG5_126791	All targets in OG5_126791

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	doublecortin family protein	0.0023	0.0034	0.0031
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0191	1
Schistosoma mansoni	lipoxygenase	0.0135	0.0384	0.0382
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0019	0.0024	0.0021
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0169	0.0491	0.2
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0013	0.001
Echinococcus multilocularis	geminin	0.0367	0.1112	0.4527
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0033	0.0068	0.0065
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0023	0.1632
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0127	0.0124
Brugia malayi	Papain family cysteine protease containing protein	0.0019	0.0023	0.002
Schistosoma mansoni	lipoxygenase	0.0094	0.0258	0.0255
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0023	0.1632
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0016	0.0013	0.0113
Brugia malayi	steroid hormone receptor	0.0033	0.0068	0.0065
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0018	0.0018	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0013	0.001
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0068	0.0065
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0023	0.1632
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0016	0.0013	0.0051
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0052	0.0124	0.1119
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0023	0.002
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0026	0.0044	0.0041
Brugia malayi	hypothetical protein	0.0016	0.0013	0.001
Schistosoma mansoni	hypothetical protein	0.0034	0.0068	0.0065
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.0127	0.1139
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0106	0.0295	0.0292
Schistosoma mansoni	transcription factor LCR-F1	0.0035	0.0074	0.0071
Trypanosoma cruzi	Voltage-dependent calcium channel subunit, putative	0.0071	0.0184	0.9599
Brugia malayi	Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog	0.0116	0.0326	0.0324
Brugia malayi	PHD-finger family protein	0.0032	0.0065	0.0062
Plasmodium falciparum	cysteine proteinase falcipain 2a	0.0019	0.0023	0.201
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0191	1
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0023	0.002
Leishmania major	hypothetical protein, conserved	0.0017	0.0018	0.0798
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0034	0.0068	0.0065
Brugia malayi	hypothetical protein	0.0018	0.0018	0.0016
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0033	0.0068	0.0065
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0023	0.1632
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0023	0.1632
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0013	0.0003	0.0011
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0023	0.1632
Schistosoma mansoni	deleted in oral cancer 1/cdk2-associated protein-like	0.0304	0.0915	0.0912
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0016	0.0013	0.0103
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0016	0.0013	0.0113
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0135	0.0384	0.1566
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0013	0.001
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0023	0.1977
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0052	0.0124	1
Brugia malayi	Nuclear hormone receptor-like 1	0.0018	0.0018	0.0016
Echinococcus multilocularis	voltage dependent calcium channel	0.0116	0.0326	0.1329
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0052	0.0124	1
Schistosoma mansoni	zinc finger protein	0.0026	0.0046	0.0043
Leishmania major	cysteine peptidase A (CPA)	0.0019	0.0023	0.1072
Brugia malayi	nuclear receptor RXR	0.0018	0.0018	0.0016
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0034	0.0031
Schistosoma mansoni	loxhd1	0.0023	0.0034	0.0031
Echinococcus multilocularis	sodium channel protein	0.0049	0.0117	0.0477
Loa Loa (eye worm)	hypothetical protein	0.0021	0.003	0.0027
Echinococcus multilocularis	zinc finger protein	0.0026	0.0046	0.0187
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0023	0.1632
Schistosoma mansoni	thyroid hormone receptor	0.0033	0.0068	0.0065
Trypanosoma cruzi	cysteine peptidase, putative	0.0019	0.0023	0.0298
Onchocerca volvulus		0.0019	0.0023	0.0217
Echinococcus granulosus	histone lysine methyltransferase setb	0.0019	0.0024	0.0217
Loa Loa (eye worm)	voltage-dependent calcium channel	0.0024	0.0039	0.0036
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0033	0.0068	0.0065
Echinococcus granulosus	fetal alzheimer antigen falz	0.0026	0.0044	0.0393
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0033	0.0068	0.0065
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0019	0.0024	0.0217
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0033	0.0068	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0013	0.001
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0016	0.0013	0.0051
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0033	0.0068	0.0065
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0033	0.0068	0.0065
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0034	0.0068	0.0278
Loa Loa (eye worm)	calcium channel	0.0116	0.0326	0.0324
Onchocerca volvulus		0.0033	0.0068	0.0709
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0033	0.0068	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0044	0.01	0.0097
Loa Loa (eye worm)	hypothetical protein	0.0177	0.0518	0.0515
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0018	0.0016
Onchocerca volvulus		0.0019	0.0023	0.0217
Schistosoma mansoni	hypothetical protein	0.0034	0.0068	0.0065
Echinococcus granulosus	geminin	0.0367	0.1112	1
Entamoeba histolytica	acetyltransferase, GNAT family	0.0045	0.0103	1
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0019	0.0024	0.0021
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0052	0.0124	1
Schistosoma mansoni	RAR-like nuclear receptor	0.0033	0.0068	0.0065
Schistosoma mansoni	nuclear receptor nhr-48	0.0016	0.0013	0.001
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0019	0.0024	0.0098
Entamoeba histolytica	cysteine proteinase, putative	0.0019	0.0023	0.1977
Onchocerca volvulus	Bile acid receptor homolog	0.0033	0.0068	0.0709
Loa Loa (eye worm)	DR-78	0.0016	0.0013	0.001
Onchocerca volvulus		0.0019	0.0023	0.0217
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0034	0.0068	0.0278
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.0191	1
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0034	0.0031
Entamoeba histolytica	hypothetical protein	0.0035	0.0074	0.7055
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0068	0.0065
Echinococcus granulosus	Polycystic kidney disease protein	0.0023	0.0034	0.0302
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0023	0.1632
Schistosoma mansoni	nuclear receptor	0.0016	0.0013	0.001
Echinococcus granulosus	nuclear receptor nhr 48	0.0016	0.0013	0.0113
Echinococcus granulosus	lipoxygenase domain containing protein	0.0023	0.0034	0.0302
Schistosoma mansoni	hypothetical protein	0.0023	0.0034	0.0031
Plasmodium falciparum	cysteine proteinase falcipain 2b	0.0019	0.0023	0.201
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0013	0.001
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0018	0.0018	0.0016
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0033	0.0068	0.0611
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0023	0.1632
Echinococcus granulosus	GPCR family 2	0.0034	0.0068	0.0613
Echinococcus granulosus	RUN	0.0023	0.0034	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0068	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0179	0.0523	0.052
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0072	0.0189	0.1702
Echinococcus granulosus	voltage dependent L type calcium channel subunit\|voltage dependent calcium channel	0.0116	0.0326	0.2936
Brugia malayi	Nuclear hormone receptor-like 1	0.0033	0.0068	0.0065
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0041	0.0092	0.0373
Loa Loa (eye worm)	transcription factor SMAD2	0.0141	0.0405	0.0403
Brugia malayi	MH2 domain containing protein	0.0141	0.0405	0.0403
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0023	0.002
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0016	0.0013	0.001
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0052	0.0127	0.0124
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0023	0.002
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0023	0.1632
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0013	0.0003	0.0025
Brugia malayi	acetyltransferase, GNAT family protein	0.0169	0.0491	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0053	0.0128	0.0125
Onchocerca volvulus	Cathepsin L homolog	0.0019	0.0023	0.0217
Schistosoma mansoni	nuclear hormone receptor	0.0016	0.0013	0.001
Entamoeba histolytica	hypothetical protein	0.0035	0.0074	0.7055
Loa Loa (eye worm)	hypothetical protein	0.0304	0.0915	0.0912
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0191	1
Leishmania major	cathepsin L-like protease	0.0073	0.0191	1
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0016	0.0013	0.001
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0016	0.0013	0.0113
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0041	0.0092	0.0823
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0068	0.0065
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0033	0.0068	0.0065
Onchocerca volvulus		0.0016	0.0013	0.0103
Schistosoma mansoni	hypothetical protein	0.0367	0.1112	0.1109
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0191	1
Schistosoma mansoni	zinc finger protein	0.0017	0.0018	0.0015
Echinococcus multilocularis	Polycystic kidney disease protein	0.0023	0.0034	0.0137
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0033	0.0068	0.0276
Echinococcus multilocularis	cathepsin L cysteine protease	0.0019	0.0023	0.0094
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0023	0.1632
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0106	0.0295	0.0292
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0023	0.1632
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0191	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0034	0.0068	0.0613
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0161	0.0468	0.4211
Onchocerca volvulus		0.0023	0.0034	0.0333
Leishmania major	cathepsin L-like protease	0.0019	0.0023	0.1072
Giardia lamblia	Histone acetyltransferase GCN5	0.0045	0.0103	0.5
Schistosoma mansoni	nuclear receptor	0.0016	0.0013	0.001
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0033	0.0068	0.0276
Onchocerca volvulus		0.0019	0.0023	0.0217
Echinococcus multilocularis	nuclear receptor nhr 48	0.0016	0.0013	0.0051
Schistosoma mansoni	hypothetical protein	0.0034	0.0068	0.0065
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0023	0.1632
Onchocerca volvulus	Diphthamide biosynthesis protein 7 homolog	0.0304	0.0915	1
Schistosoma mansoni	nuclear hormone receptor	0.0033	0.0068	0.0065
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0033	0.0068	0.0065
Leishmania major	cathepsin L-like protease	0.0073	0.0191	1
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0127	0.0124
Echinococcus multilocularis	cGMP dependent protein kinase 1	0.0013	0.0003	0.0011
Schistosoma mansoni	hypothetical protein	0.0035	0.0074	0.0071
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0068	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0068	0.0065
Onchocerca volvulus		0.0019	0.0023	0.0217
Brugia malayi	Bromodomain containing protein	0.0048	0.0113	0.011
Brugia malayi	nuclear receptor NHR-67	0.0016	0.0013	0.001
Loa Loa (eye worm)	fibroinase	0.0019	0.0023	0.002
Onchocerca volvulus	Protein ultraspiracle homolog	0.0033	0.0068	0.0709
Trypanosoma brucei	Voltage-dependent calcium channel subunit, putative	0.0071	0.0184	0.9599
Brugia malayi	hypothetical protein	0.0023	0.0034	0.0031
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0016	0.0013	0.001
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0033	0.0068	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0081	0.0216	0.0213
Schistosoma mansoni	voltage-gated cation channel	0.0116	0.0326	0.0324
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0033	0.0068	0.0065
Echinococcus granulosus	FTZ F1 alpha	0.0033	0.0068	0.0611
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0035	0.0074	0.0664
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0023	0.1632
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0068	0.0065
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0018	0.0018	0.0166
Brugia malayi	latrophilin 2 splice variant baaae	0.0072	0.019	0.0187
Entamoeba histolytica	hypothetical protein	0.0035	0.0074	0.7055
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0013	0.001
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0033	0.0068	0.0065
Brugia malayi	hypothetical protein	0.0179	0.0523	0.052
Brugia malayi	nuclear receptor RXR	0.0016	0.0013	0.001
Echinococcus multilocularis	GPCR, family 2	0.0034	0.0068	0.0278
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.0023	0.002
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0116	0.0326	0.1329
Loa Loa (eye worm)	PHD-finger family protein	0.0024	0.0037	0.0034
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0013	0.001
Onchocerca volvulus		0.0019	0.0023	0.0217
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0191	1
Onchocerca volvulus	Cathepsin L homolog	0.0019	0.0023	0.0217
Brugia malayi	Nuclear hormone receptor E75	0.0016	0.0013	0.001
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0023	0.0034	0.0137
Echinococcus multilocularis	cathepsin L cysteine protease	0.0019	0.0023	0.0094
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0072	0.0189	0.077
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0135	0.0384	0.3459
Loa Loa (eye worm)	ctsf protein	0.0019	0.0023	0.002
Schistosoma mansoni	hypothetical protein	0.0017	0.0018	0.0015
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0023	0.1632
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.0049	0.0117	0.1055
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel alpha 1	0.0116	0.0326	0.2936
Schistosoma mansoni	hypothetical protein	0.0072	0.019	0.0187
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0033	0.0068	0.0065
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0016	0.0013	0.0051
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0191	1
Brugia malayi	hypothetical protein	0.0016	0.0013	0.001
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0023	0.002
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0019	0.0024	0.0098
Loa Loa (eye worm)	hypothetical protein	0.0024	0.0039	0.0036
Leishmania major	cathepsin L-like protease	0.0019	0.0023	0.1072
Onchocerca volvulus		0.0179	0.0523	0.5699
Brugia malayi	conserved hypotetical protein	0.0016	0.0013	0.001
Loa Loa (eye worm)	hypothetical protein	0.0021	0.003	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0072	0.019	0.0187
Loa Loa (eye worm)	hypothetical protein	0.0051	0.0121	0.0119
Echinococcus granulosus	ecdysone induced protein 78C	0.0033	0.0068	0.0611
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0023	0.1632
Leishmania major	cathepsin L-like protease	0.0073	0.0191	1
Schistosoma mansoni	hypothetical protein	0.0367	0.1112	0.1109
Leishmania major	cathepsin L-like protease	0.0019	0.0023	0.1072
Leishmania major	cathepsin L-like protease	0.0019	0.0023	0.1072
Entamoeba histolytica	cysteine protease, putative	0.0019	0.0023	0.1977
Toxoplasma gondii	transporter, cation channel family protein	0.0024	0.0039	0.2995
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0013	0.001
Onchocerca volvulus		0.0019	0.0023	0.0217
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0191	1
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0013	0.001
Echinococcus granulosus	voltage dependent calcium channel	0.0024	0.0039	0.0353
Schistosoma mansoni	thyroid hormone receptor	0.0033	0.0068	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0068	0.0065
Echinococcus granulosus	voltage dependent calcium channel type d subunit\|voltage dependent calcium channel\|voltage dependent L type calcium channel subu	0.0116	0.0326	0.2936
Schistosoma mansoni	zinc finger protein	0.0016	0.0013	0.001
Brugia malayi	nuclear hormone receptor	0.0033	0.0068	0.0065
Brugia malayi	ecdysteroid receptor	0.0033	0.0068	0.0065
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0033	0.0068	0.0611
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0019	0.0024	0.0021
Brugia malayi	hypothetical protein	0.0023	0.0034	0.0031
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0018	0.0018	0.0075
Brugia malayi	Cathepsin L-like precursor	0.0019	0.0023	0.002
Echinococcus granulosus	thyroid hormone receptor alpha	0.0016	0.0013	0.0113
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0023	0.1632
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0013	0.001
Schistosoma mansoni	retinoic acid receptor RXR	0.0033	0.0068	0.0065
Echinococcus granulosus	voltage dependent calcium channel	0.0116	0.0326	0.2936
Loa Loa (eye worm)	CAMK/CAMKL/CHK1 protein kinase	0.3207	1	1
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0033	0.0068	0.0065
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0033	0.0068	0.0611
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0023	0.0034	0.0137
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0016	0.0013	0.001
Echinococcus multilocularis	voltage dependent calcium channel	0.0116	0.0326	0.1329
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0033	0.0068	0.0065
Brugia malayi	tailless protein	0.0016	0.0013	0.001
Echinococcus multilocularis	expressed conserved protein	0.0013	0.0003	0.0011
Brugia malayi	nuclear hormone receptor	0.0016	0.0013	0.001
Echinococcus multilocularis	voltage dependent calcium channel type d subunit	0.0116	0.0326	0.1329
Schistosoma mansoni	hypothetical protein	0.0024	0.0037	0.0034
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0016	0.0013	0.0113
Schistosoma mansoni	polycystin 1-related	0.0023	0.0034	0.0031
Brugia malayi	Nuclear hormone receptor E75	0.0016	0.0013	0.001
Echinococcus multilocularis	FTZ F1 alpha	0.0033	0.0068	0.0276
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0033	0.0068	0.0065
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0191	1
Brugia malayi	nuclear hormone receptor family member odr-7	0.0016	0.0013	0.001
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0033	0.0068	0.0276
Loa Loa (eye worm)	MH2 domain-containing protein	0.0141	0.0405	0.0403
Brugia malayi	N-terminal motif family protein	0.0177	0.0518	0.0515
Schistosoma mansoni	nuclear hormone receptor	0.0016	0.0013	0.001
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0052	0.0124	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0191	1
Trypanosoma cruzi	major cysteine proteinase, putative	0.0057	0.0142	0.7185
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0033	0.0068	0.0065
Schistosoma mansoni	hypothetical protein	0.0034	0.0068	0.0065
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0052	0.0127	0.0124
Echinococcus granulosus	cGMP dependent protein kinase 1	0.0013	0.0003	0.0025
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0023	0.1632
Brugia malayi	hypothetical protein	0.0018	0.0018	0.0016
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0052	0.0124	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0068	0.0065
Schistosoma mansoni	rab6-interacting	0.0023	0.0034	0.0031
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0106	0.0295	0.0292
Echinococcus multilocularis	Cyclin dependent kinase 2 associated protein	0.0304	0.0915	0.3726
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0033	0.0068	0.0709
Brugia malayi	hypothetical protein	0.0995	0.3077	0.3075
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0033	0.0068	0.0065
Brugia malayi	Bromodomain containing protein	0.009	0.0244	0.0241
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.0127	0.0515
Echinococcus multilocularis	atpase aaa+ type core atpase aaa type core	0.0796	0.2456	1
Loa Loa (eye worm)	hypothetical protein	0.0116	0.0326	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0106	0.0295	0.0292
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0033	0.0068	0.0276
Plasmodium falciparum	cysteine proteinase falcipain 3	0.0019	0.0023	0.201
Brugia malayi	Steroid receptor seven-up type 2	0.0033	0.0068	0.0065
Loa Loa (eye worm)	acetyltransferase	0.0169	0.0491	0.0488
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0052	0.0127	0.0124
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0033	0.0068	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0013	0.001
Schistosoma mansoni	coup transcription factor	0.0033	0.0068	0.0065
Toxoplasma gondii	cathepsin CPL	0.0019	0.0023	0.166
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.0191	1
Schistosoma mansoni	serine/threonine protein kinase	0.3207	1	1
Plasmodium vivax	multidomain scavenger receptor, putative	0.0023	0.0034	0.1047
Echinococcus granulosus	cathepsin l1	0.0013	0.0003	0.0029
Echinococcus granulosus	cathepsin l cysteine peptidase	0.0019	0.0023	0.0207
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0019	0.0023	0.1632
Brugia malayi	hypothetical protein	0.0035	0.0074	0.0071
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0033	0.0068	0.0611
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0033	0.0068	0.0611
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0033	0.0068	0.0065
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0019	0.0023	0.0094
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0073	0.0191	1
Echinococcus granulosus	cathepsin l1	0.0019	0.0023	0.0207
Brugia malayi	nuclear receptor NHR-88	0.0033	0.0068	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0018	0.0016
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0034	0.0068	0.0613
Plasmodium falciparum	LCCL domain-containing protein	0.0023	0.0034	0.3067
Loa Loa (eye worm)	cysteine protease	0.0019	0.0023	0.002
Schistosoma mansoni	bromodomain containing protein	0.0076	0.0202	0.0199
Entamoeba histolytica	hypothetical protein	0.0035	0.0074	0.7055
Onchocerca volvulus	Cathepsin F homolog	0.0019	0.0023	0.0217
Brugia malayi	Latrophilin receptor protein 2	0.0034	0.0068	0.0065
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0033	0.0068	0.0611
Trypanosoma cruzi	cruzipain precursor, putative	0.0073	0.0191	1
Brugia malayi	Doublecortin family protein	0.0023	0.0034	0.0031
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0033	0.0068	0.0065
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0016	0.0013	0.0103
Echinococcus multilocularis	RUN	0.0023	0.0034	0.0137
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.0066	0.0171	0.8859
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0024	0.0021
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0016	0.0013	0.001
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0116	0.0326	0.1329
Brugia malayi	Nuclear hormone receptor-like 1	0.0018	0.0018	0.0016
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0035	0.0074	0.03
Trichomonas vaginalis	Clan CA, family C1, cathepsin L or K-like cysteine peptidase	0.0019	0.0023	0.1632
Trypanosoma cruzi	cysteine peptidase, putative	0.0073	0.0191	1
Brugia malayi	nuclear receptor NHR-88	0.0016	0.0013	0.001
Loa Loa (eye worm)	bromodomain containing protein	0.0024	0.0039	0.0036
Onchocerca volvulus		0.0023	0.0034	0.0333
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0033	0.0068	0.0611
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0013	0.001
Loa Loa (eye worm)	Papain cysteine protease/cathepsin propeptide inhibitor-containing protein	0.0019	0.0023	0.002
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0033	0.0068	0.0065
Schistosoma mansoni	high voltage-activated calcium channel Cav1	0.0116	0.0326	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0018	0.0016
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0016	0.0013	0.0051
Onchocerca volvulus		0.0016	0.0013	0.0103
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0023	0.1632
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0033	0.0068	0.0065
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0033	0.0068	0.0276
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0026	0.0044	0.0178
Brugia malayi	photoreceptor-specific nuclear receptor	0.0033	0.0068	0.0065
Schistosoma mansoni	high voltage-activated calcium channel Cav2A	0.0116	0.0326	0.0324
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0023	0.1632
Echinococcus granulosus	cGMP dependent protein kinase	0.0013	0.0003	0.0025
Echinococcus multilocularis	voltage dependent L type calcium channel subunit	0.0116	0.0326	0.1329
Echinococcus multilocularis	cysteine protease	0.0019	0.0023	0.0094
Echinococcus granulosus	zinc finger protein	0.0026	0.0046	0.0412
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0023	0.1632
Echinococcus multilocularis	ecdysone induced protein 78C	0.0033	0.0068	0.0276
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0018	0.0016
Echinococcus granulosus	Cyclin dependent kinase 2 associated protein	0.0304	0.0915	0.823
Trichomonas vaginalis	Clan CA, family C1, papain-like cysteine peptidase	0.0019	0.0023	0.1632
Echinococcus multilocularis	cysteine protease	0.0019	0.0023	0.0094
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0052	0.0127	0.1139
Schistosoma mansoni	rab6-interacting	0.0023	0.0034	0.0031
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0169	0.0491	0.0488
Loa Loa (eye worm)	hypothetical protein	0.0016	0.0013	0.001
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0033	0.0068	0.0065
Echinococcus granulosus	cathepsin L cysteine proteinase	0.0019	0.0023	0.0207
Schistosoma mansoni	cathepsin F (C01 family)	0.0019	0.0023	0.002
Toxoplasma gondii	hypothetical protein	0.0021	0.003	0.224
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0016	0.0013	0.001
Loa Loa (eye worm)	steroid hormone receptor	0.0033	0.0068	0.0065
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0033	0.0068	0.0065
Leishmania major	cathepsin L-like protease	0.0019	0.0023	0.1072
Brugia malayi	orphan nuclear receptor NR2E1	0.0016	0.0013	0.001
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0177	0.0518	0.5647
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0033	0.0068	0.0065
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0023	0.002
Echinococcus granulosus	lipoxygenase domain containing protein	0.0023	0.0034	0.0302
Loa Loa (eye worm)	hypothetical protein	0.0018	0.0018	0.0016
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0016	0.0013	0.0051
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0033	0.0068	0.0065
Trichomonas vaginalis	Clan CA, family C1, cathepsin L-like cysteine peptidase	0.0019	0.0023	0.1632
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0019	0.0024	0.0021
Loa Loa (eye worm)	papain family cysteine protease containing protein	0.0019	0.0023	0.002
Loa Loa (eye worm)	nuclear hormone receptor	0.0016	0.0013	0.001
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0034	0.0068	0.0065
Echinococcus multilocularis	cathepsin l cysteine peptidase	0.0019	0.0023	0.0094
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0052	0.0127	0.0515
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0018	0.0018	0.0016
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0033	0.0068	0.0065
Brugia malayi	ecdysone receptor	0.0016	0.0013	0.001
Plasmodium falciparum	histone acetyltransferase GCN5	0.0045	0.0103	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 10.5 uM	PUBCHEM_BIOASSAY: SAR analysis of small molecule inhibitors of Mint-PDZ and N-type Ca2+ channel carboxyl-terminal peptide association using HTRF - Set 2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2073, AID2091, AID2093, AID2489]	ChEMBL.	No reference
IC50 (functional)	= 11.7 uM	PUBCHEM_BIOASSAY: SAR analysis of small molecule inhibitors of Mint-PDZ and N-type Ca2+ channel carboxyl-terminal peptide association using HTRF. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2073, AID2091, AID2093, AID434980]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1709589

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1531987