Detailed information for compound 1532848

Basic information

Technical information
  • TDR Targets ID: 1532848
  • Name: 3-(1,2-oxazolidin-2-yl)-1-[3-[4-(trifluoromet hyl)benzoyl]piperidin-1-yl]propan-1-one
  • MW: 384.393 | Formula: C19H23F3N2O3
  • H donors: 0 H acceptors: 2 LogP: 2.59 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(N1CCCC(C1)C(=O)c1ccc(cc1)C(F)(F)F)CCN1CCCO1
  • InChi: 1S/C19H23F3N2O3/c20-19(21,22)16-6-4-14(5-7-16)18(26)15-3-1-9-23(13-15)17(25)8-11-24-10-2-12-27-24/h4-7,15H,1-3,8-13H2
  • InChiKey: WEMKWDOXSOVRQX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-isoxazolidin-2-yl-1-[3-[4-(trifluoromethyl)benzoyl]-1-piperidyl]propan-1-one
  • 3-(2-isoxazolidinyl)-1-[3-[oxo-[4-(trifluoromethyl)phenyl]methyl]-1-piperidinyl]propan-1-one
  • 3-(1,2-oxazolidin-2-yl)-1-[3-[4-(trifluoromethyl)phenyl]carbonylpiperidin-1-yl]propan-1-one
  • MLS000734334
  • SMR000316730
  • [1-(3-isoxazolidin-2-ylpropanoyl)piperidin-3-yl][4-(trifluoromethyl)phenyl]methanone

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens K(lysine) acetyltransferase 2A Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium parvum GCN5 like acetylase + bromodomain Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma japonicum ko:K06062 p300/CBP-associated factor, putative Get druggable targets OG5_127781 All targets in OG5_127781
Brugia malayi acetyltransferase, GNAT family protein Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium vivax histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium falciparum histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium berghei histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis Get druggable targets OG5_127781 All targets in OG5_127781
Entamoeba histolytica acetyltransferase, GNAT family Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum hypothetical protein Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium yoelii histone acetyltransferase GCN5-related Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative Get druggable targets OG5_127781 All targets in OG5_127781
Neospora caninum Bromodomain containing protein, related Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-A Get druggable targets OG5_127781 All targets in OG5_127781
Giardia lamblia Histone acetyltransferase GCN5 Get druggable targets OG5_127781 All targets in OG5_127781
Echinococcus granulosus histone acetyltransferase KAT2B Get druggable targets OG5_127781 All targets in OG5_127781
Trichomonas vaginalis bromodomain-containing protein, putative Get druggable targets OG5_127781 All targets in OG5_127781
Cryptosporidium hominis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Plasmodium knowlesi histone acetyltransferase GCN5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Theileria parva histone acetyltransferase Gcn5, putative Get druggable targets OG5_127781 All targets in OG5_127781
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 Get druggable targets OG5_127781 All targets in OG5_127781
Toxoplasma gondii histone lysine acetyltransferase GCN5-B Get druggable targets OG5_127781 All targets in OG5_127781
Candida albicans bromodomain protein similar to S. cerevisiae GCN5 (YGR252W) histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Loa Loa (eye worm) acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
Babesia bovis histone acetyltransferase Get druggable targets OG5_127781 All targets in OG5_127781
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0026 0.0096 0.0175
Loa Loa (eye worm) MBCTL1 0.0096 0.0931 0.1779
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0048
Loa Loa (eye worm) hypothetical protein 0.0025 0.009 0.0172
Schistosoma mansoni nAChR subunit 0.0033 0.018 0.018
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0108 0.1067 0.1067
Echinococcus granulosus neuroligin 0.0026 0.0096 0.016
Loa Loa (eye worm) hypothetical protein 0.0153 0.1602 0.3062
Loa Loa (eye worm) hypothetical protein 0.0108 0.1067 0.2038
Loa Loa (eye worm) hypothetical protein 0.0033 0.018 0.0344
Onchocerca volvulus 0.0304 0.3382 0.6154
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0129 0.1319 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0241 0.0461
Schistosoma mansoni phd finger protein 0.0041 0.0275 0.0275
Echinococcus multilocularis musashi 0.0027 0.0104 0.0114
Echinococcus granulosus liprin alpha 2 0.0025 0.009 0.015
Loa Loa (eye worm) hypothetical protein 0.0026 0.0098 0.0187
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0072 0.0646 0.0646
Loa Loa (eye worm) hypothetical protein 0.0026 0.0096 0.0183
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0482 0.0804
Onchocerca volvulus 0.0025 0.009 0.0164
Loa Loa (eye worm) hypothetical protein 0.0033 0.018 0.0344
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0241 0.0461
Onchocerca volvulus 0.0025 0.009 0.0164
Toxoplasma gondii preprocathepsin c precursor, putative 0.0129 0.1319 1
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0104 0.0198
Schistosoma mansoni nAChR subunit 0.0033 0.018 0.018
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0033 0.018 0.0344
Onchocerca volvulus 0.0038 0.0241 0.0439
Schistosoma mansoni Protein aveugle 0.0025 0.009 0.009
Schistosoma mansoni jumonji domain containing protein 0.0026 0.0092 0.0092
Loa Loa (eye worm) hypothetical protein 0.0038 0.0241 0.0461
Loa Loa (eye worm) hypothetical protein 0.0033 0.018 0.0344
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0096 0.0048
Echinococcus granulosus polyhomeotic protein 2 0.0025 0.009 0.015
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0115 0.1148 0.1267
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0026 0.0096 0.016
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0033 0.018 0.0199
Onchocerca volvulus 0.0108 0.1067 0.1941
Loa Loa (eye worm) hypothetical protein 0.0025 0.009 0.0172
Loa Loa (eye worm) hypothetical protein 0.0096 0.0931 0.1779
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0484 1
Echinococcus multilocularis sphingomyelin synthase protein 1 0.0025 0.009 0.0099
Loa Loa (eye worm) hypothetical protein 0.0033 0.018 0.0344
Loa Loa (eye worm) hypothetical protein 0.0026 0.0096 0.0183
Onchocerca volvulus 0.0033 0.018 0.0328
Onchocerca volvulus Tankyrase homolog 0.0025 0.009 0.0164
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.018 0.0344
Brugia malayi Liprin-alpha 2 0.0025 0.009 0.0172
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.036 0.0687
Schistosoma mansoni hypothetical protein 0.0338 0.3785 0.3785
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0096 0.0012
Mycobacterium ulcerans hypothetical protein 0.0038 0.0241 0.3749
Loa Loa (eye worm) hypothetical protein 0.0025 0.009 0.0172
Brugia malayi Sphingomyelin synthase-related 1 0.0025 0.009 0.0172
Schistosoma mansoni hypothetical protein 0.0033 0.0179 0.0179
Echinococcus granulosus pdz domain containing protein 0.0025 0.009 0.015
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0241 0.0564
Toxoplasma gondii PLU-1 family protein 0.0044 0.0313 0.1784
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1419 0.1419
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0399 0.2488
Trichomonas vaginalis spcc417.12 protein, putative 0.0026 0.0096 0.0011
Loa Loa (eye worm) hypothetical protein 0.0243 0.2665 0.5094
Loa Loa (eye worm) hypothetical protein 0.0025 0.009 0.0172
Echinococcus multilocularis histone acetyltransferase MYST2 0.0096 0.0931 0.1027
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0129 0.1319 1
Onchocerca volvulus 0.0072 0.0646 0.1175
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0104 0.0198
Schistosoma mansoni myelin transcription factor 1 myt1 0.0096 0.0931 0.0931
Onchocerca volvulus 0.0026 0.0096 0.0175
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0241 0.3749
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0025 0.009 0.0172
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0027 0.0111 0.0186
Echinococcus granulosus polyhomeotic proximal chromatin protein 0.0025 0.009 0.015
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0033 0.018 0.018
Schistosoma mansoni chromobox protein 0.0198 0.2136 0.2136
Loa Loa (eye worm) hypothetical protein 0.0026 0.0096 0.0183
Echinococcus multilocularis acetylcholinesterase 0.0153 0.1602 0.1768
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.1419 0.2366
Schistosoma mansoni gliotactin 0.0026 0.0096 0.0096
Echinococcus granulosus glycine receptor subunit alpha 1 0.0033 0.018 0.03
Echinococcus multilocularis polycomb protein SCMH1 0.0267 0.2953 0.3259
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0033 0.018 0.03
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0348 1
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0033 0.018 0.0344
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0025 0.009 0.0172
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.018 0.0344
Brugia malayi Carboxylesterase family protein 0.0153 0.1602 0.3062
Mycobacterium tuberculosis Conserved protein 0.0038 0.0241 0.0564
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0033 0.018 0.0344
Brugia malayi hypothetical protein 0.0025 0.009 0.0172
Echinococcus multilocularis geminin 0.0338 0.3785 0.4176
Loa Loa (eye worm) hypothetical protein 0.0033 0.018 0.0344
Loa Loa (eye worm) ACC-1 protein 0.0033 0.018 0.0344
Brugia malayi AIDA-1b 0.0025 0.009 0.0172
Loa Loa (eye worm) hypothetical protein 0.046 0.5232 1
Brugia malayi jmjC domain containing protein 0.0138 0.1421 0.2715
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0138 0.1419 0.2711
Echinococcus multilocularis acetylcholinesterase 0.0153 0.1602 0.1768
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0484 0.0807
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0033 0.018 0.0199
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0348 0.2102
Schistosoma mansoni neuroligin 3 (S09 family) 0.0026 0.0096 0.0096
Echinococcus multilocularis lamin dm0 0.0027 0.0104 0.0114
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0033 0.018 0.0199
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.046 0.5232 0.952
Onchocerca volvulus Huntingtin homolog 0.0243 0.2665 0.4849
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0104 0.0198
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.1419 0.1566
Echinococcus granulosus chromobox protein 2 0.0198 0.2136 0.3562
Echinococcus granulosus muscleblind protein 0.0315 0.3518 0.5868
Loa Loa (eye worm) hypothetical protein 0.0033 0.018 0.0344
Echinococcus granulosus histone acetyltransferase myst3 0.0041 0.0275 0.0458
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0033 0.018 0.03
Loa Loa (eye worm) carboxylesterase 0.0153 0.1602 0.3062
Echinococcus multilocularis liprin alpha 2 0.0025 0.009 0.0099
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.1861 0.3557
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0033 0.018 0.0344
Leishmania major hypothetical protein, conserved 0.0038 0.0241 0.3752
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0241 0.028
Echinococcus granulosus tumor suppressor p53 binding protein 1 0.0329 0.3686 0.6147
Loa Loa (eye worm) hypothetical protein 0.0033 0.018 0.0344
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0138 0.1419 0.2711
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0096 0.0931 0.1027
Loa Loa (eye worm) carboxylesterase 0.0026 0.0096 0.0183
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0241 0.0564
Schistosoma mansoni bromodomain containing protein 0.002 0.0025 0.0025
Schistosoma mansoni spingomyelin synthetase-related 0.0025 0.009 0.009
Schistosoma mansoni sex comb on midleg homolog 0.0267 0.2953 0.2953
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0241 0.1233
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0026 0.0096 0.0106
Loa Loa (eye worm) hypothetical protein 0.0033 0.0179 0.0343
Schistosoma mansoni bromodomain containing protein 0.002 0.0025 0.0025
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0025 0.009 0.009
Echinococcus multilocularis Sterile alpha motif SAM 0.0025 0.009 0.0099
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0244 0.2676 1
Schistosoma mansoni hypothetical protein 0.0025 0.009 0.009
Echinococcus granulosus sphingomyelin synthase protein 1 0.0025 0.009 0.015
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0033 0.018 0.03
Echinococcus multilocularis lysine specific demethylase 5A 0.0078 0.0713 0.0787
Loa Loa (eye worm) tnks protein 0.0025 0.009 0.0172
Echinococcus multilocularis sterile alpha and tir motif containing protein 0.0025 0.009 0.0099
Onchocerca volvulus Putative nachr subunit 0.0033 0.018 0.0328
Schistosoma mansoni nAChR subunit 0.0033 0.018 0.018
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0179 0.0343
Schistosoma mansoni hypothetical protein 0.0338 0.3785 0.3785
Mycobacterium tuberculosis Conserved protein 0.0038 0.0241 0.0564
Schistosoma mansoni lamin 0.0027 0.0104 0.0104
Echinococcus granulosus lamin dm0 0.0027 0.0104 0.0173
Loa Loa (eye worm) hypothetical protein 0.0048 0.036 0.0687
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0033 0.018 0.0199
Schistosoma mansoni nAChR subunit 0.0033 0.018 0.018
Brugia malayi Pre-SET motif family protein 0.0424 0.4803 0.918
Brugia malayi hypothetical protein 0.0026 0.0096 0.0183
Loa Loa (eye worm) hypothetical protein 0.0093 0.0886 0.1694
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0033 0.018 0.0344
Echinococcus granulosus Sterile alpha motif type 0.0025 0.009 0.015
Schistosoma mansoni acetylcholinesterase 0.0026 0.0096 0.0096
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0033 0.018 0.0199
Brugia malayi mbt repeat family protein 0.046 0.5232 1
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0033 0.018 0.018
Schistosoma mansoni SET domain protein 0.0018 0.0001 0.0001
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0524 0.5996 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.018 0.0344
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0138 0.1419 0.1566
Onchocerca volvulus 0.0482 0.5496 1
Echinococcus multilocularis polyhomeotic protein 2 0.0025 0.009 0.0099
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0524 0.5996 0.6617
Brugia malayi hypothetical protein 0.0243 0.2665 0.5094
Echinococcus multilocularis muscleblind protein 1 0.0315 0.3518 0.3883
Loa Loa (eye worm) acetyltransferase 0.0175 0.1861 0.3557
Brugia malayi Carboxylesterase family protein 0.0026 0.0096 0.0183
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0241 0.3749
Brugia malayi coiled-coil like protein 1 0.0025 0.009 0.0172
Schistosoma mansoni sex comb on midleg homolog 0.0267 0.2953 0.2953
Brugia malayi PHD-finger family protein 0.002 0.0025 0.0048
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0096 0.0386
Echinococcus granulosus liprin alpha 2 0.0025 0.009 0.015
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0033 0.018 0.0344
Trichomonas vaginalis set domain proteins, putative 0.0482 0.5496 1
Loa Loa (eye worm) hypothetical protein 0.0243 0.2665 0.5094
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.1861 0.1861
Loa Loa (eye worm) hypothetical protein 0.0108 0.1067 0.2038
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0033 0.018 0.0199
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0241 0.0564
Echinococcus multilocularis BC026374 protein (S09 family) 0.0026 0.0096 0.0106
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0033 0.018 0.0344
Onchocerca volvulus 0.0025 0.009 0.0164
Brugia malayi mbt repeat family protein 0.0278 0.3082 0.589
Echinococcus granulosus nAChR subunit 0.0033 0.018 0.03
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0129 0.1319 0.2273
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0108 0.1067 0.1067
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0241 0.028
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0484 1
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0241 1
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0484 0.3183
Echinococcus granulosus lamin 0.0027 0.0104 0.0173
Brugia malayi jmjC domain containing protein 0.0026 0.0092 0.0176
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0033 0.018 0.0344
Schistosoma mansoni intermediate filament proteins 0.0027 0.0104 0.0104
Onchocerca volvulus 0.0033 0.018 0.0328
Echinococcus multilocularis nAChR subunit 0.0033 0.018 0.0199
Schistosoma mansoni lamin 0.0027 0.0104 0.0104
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0033 0.018 0.03
Loa Loa (eye worm) hypothetical protein 0.0033 0.018 0.0344
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0033 0.018 0.03
Echinococcus granulosus para nitrobenzyl esterase 0.0026 0.0096 0.016
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0033 0.018 0.0344
Schistosoma mansoni nAChR subunit 0.0033 0.018 0.018
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0026 0.0096 0.0096
Echinococcus multilocularis Sterile alpha motif type 0.0025 0.009 0.0099
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0241 1
Echinococcus multilocularis chromobox protein 2 0.0198 0.2136 0.2357
Mycobacterium tuberculosis Conserved protein 0.0038 0.0241 0.0564
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0399 0.0572
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0387 0.4371 0.4371
Brugia malayi beta-lactamase family protein 0.0038 0.0241 0.0461
Echinococcus multilocularis lamin 0.0027 0.0104 0.0114
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0026 0.0092 0.0154
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0061 0.0509 0.0561
Echinococcus multilocularis polyhomeotic proximal chromatin protein 0.0025 0.009 0.0099
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0033 0.018 0.03
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0026 0.0096 0.0011
Loa Loa (eye worm) beta-lactamase 0.0038 0.0241 0.0461
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0241 0.0461
Onchocerca volvulus 0.0027 0.0104 0.0189
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0484 0.0484
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0509 0.0509
Onchocerca volvulus Huntingtin homolog 0.0243 0.2665 0.4849
Echinococcus granulosus SAM and MBT domain containing protein 0.0387 0.4371 0.7291
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0399 0.2488
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0033 0.018 0.03
Schistosoma mansoni Protein aveugle 0.0025 0.009 0.009
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0033 0.018 0.018
Loa Loa (eye worm) hypothetical protein 0.0038 0.0241 0.0461
Brugia malayi SET domain containing protein 0.0018 0.0001 0.0002
Brugia malayi Pre-SET motif family protein 0.0061 0.0509 0.0972
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0241 0.0564
Onchocerca volvulus 0.0033 0.018 0.0328
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0241 0.0241
Mycobacterium leprae Probable lipase LipE 0.0038 0.0241 0.5
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.002 0.0025 0.0042
Brugia malayi CHD4 protein 0.0027 0.0111 0.0213
Loa Loa (eye worm) acetylcholinesterase 1 0.0153 0.1602 0.3062
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0027 0.0111 0.0111
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0033 0.018 0.03
Schistosoma mansoni polyhomeotic 0.0025 0.009 0.009
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0027 0.0111 0.0123
Loa Loa (eye worm) carboxylesterase 0.0026 0.0096 0.0183
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0061 0.0509 0.0509
Loa Loa (eye worm) hypothetical protein 0.0025 0.009 0.0172
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0241 0.0266
Echinococcus multilocularis carboxylesterase 5A 0.0153 0.1602 0.1768
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0033 0.018 0.0344
Brugia malayi Carboxylesterase family protein 0.0026 0.0096 0.0183
Onchocerca volvulus 0.0026 0.0096 0.0175
Toxoplasma gondii ABC1 family protein 0.0038 0.0241 0.1202
Brugia malayi Cation transporter family protein 0.0033 0.018 0.0344
Echinococcus multilocularis SAM and MBT domain containing protein 0.0387 0.4371 0.4824
Loa Loa (eye worm) hypothetical protein 0.0027 0.0104 0.0198
Echinococcus granulosus geminin 0.0338 0.3785 0.6312
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0096 0.0931 0.1779
Echinococcus granulosus Sterile alpha motif SAM 0.0025 0.009 0.015
Echinococcus multilocularis muscleblind protein 0.0315 0.3518 0.3883
Echinococcus granulosus histone acetyltransferase MYST2 0.0096 0.0931 0.1552
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0026 0.0092 0.0102
Echinococcus granulosus polycomb protein SCMH1 0.0267 0.2953 0.4926
Echinococcus granulosus histone lysine methyltransferase setb 0.0061 0.0509 0.0849
Loa Loa (eye worm) hypothetical protein 0.0061 0.0509 0.0972
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0033 0.018 0.0344
Loa Loa (eye worm) mbt repeat family protein 0.0278 0.3082 0.589
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0241 0.0241
Schistosoma mansoni lip-related protein (liprin) alpha 0.0025 0.009 0.009
Brugia malayi hypothetical protein 0.0026 0.0096 0.0183
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0061 0.0509 0.0561
Echinococcus granulosus acetylcholinesterase 0.0153 0.1602 0.2672
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0033 0.018 0.0199
Onchocerca volvulus 0.0038 0.0241 0.0439
Echinococcus multilocularis zinc finger protein 0.002 0.0025 0.0028
Loa Loa (eye worm) hypothetical protein 0.0026 0.0096 0.0183
Toxoplasma gondii cathepsin CPC1 0.0129 0.1319 1
Echinococcus granulosus acetylcholinesterase 0.0153 0.1602 0.2672
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0033 0.018 0.0344
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0129 0.1319 1
Loa Loa (eye worm) AIDA-1b 0.0025 0.009 0.0172
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0033 0.018 0.0199
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0071 0.0631 0.4387
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0348 0.2064
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0033 0.018 0.0344
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0241 0.0564
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0026 0.0096 0.0096
Loa Loa (eye worm) hypothetical protein 0.0038 0.0241 0.0461
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0026 0.0096 0.0096
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0241 0.028
Onchocerca volvulus 0.0026 0.0096 0.0175
Echinococcus multilocularis histone acetyltransferase myst3 0.0041 0.0275 0.0303
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0129 0.1319 1
Brugia malayi beta-lactamase 0.0038 0.0241 0.0461
Brugia malayi cask-interacting protein 2 0.0025 0.009 0.0172
Echinococcus granulosus carboxylesterase 5A 0.0153 0.1602 0.2672
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0033 0.018 0.0199
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.018 0.0344
Mycobacterium ulcerans lipase LipD 0.0038 0.0241 0.3749
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0115 0.1148 0.1915
Loa Loa (eye worm) ACC-1 protein 0.0033 0.018 0.0344
Loa Loa (eye worm) hypothetical protein 0.0033 0.018 0.0344
Loa Loa (eye worm) hypothetical protein 0.0026 0.0096 0.0183
Loa Loa (eye worm) hypothetical protein 0.0038 0.0241 0.0461
Echinococcus granulosus lysine specific demethylase 5A 0.0094 0.0898 0.1497
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0033 0.018 0.0344
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0096 0.0386
Schistosoma mansoni jumonji/arid domain-containing protein 0.0094 0.0898 0.0898
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0033 0.018 0.0199
Loa Loa (eye worm) hypothetical protein 0.0033 0.018 0.0344
Echinococcus granulosus zinc finger protein 0.002 0.0025 0.0042
Echinococcus multilocularis para nitrobenzyl esterase 0.0026 0.0096 0.0106
Loa Loa (eye worm) jmjC domain-containing protein 0.0138 0.1421 0.2715
Loa Loa (eye worm) hypothetical protein 0.0025 0.009 0.0172
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0241 0.028
Plasmodium vivax JmjC domain containing protein 0.0029 0.0136 0.0374
Plasmodium falciparum JmjC domain-containing protein, putative 0.0029 0.0136 0.0328
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0241 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.036 0.0687
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0399 0.2515
Loa Loa (eye worm) hypothetical protein 0.0025 0.009 0.0172
Loa Loa (eye worm) hypothetical protein 0.0033 0.018 0.0344
Brugia malayi Cation transporter family protein 0.0033 0.018 0.0344
Loa Loa (eye worm) hypothetical protein 0.0315 0.3518 0.6724
Brugia malayi Carboxylesterase family protein 0.0026 0.0096 0.0183
Echinococcus granulosus glycine receptor subunit beta 0.0033 0.018 0.03
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0241 0.028
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0783 0.9062 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0048
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1419 0.1419
Echinococcus granulosus BC026374 protein S09 family 0.0026 0.0096 0.016
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.1803 0.3007
Loa Loa (eye worm) hypothetical protein 0.0315 0.3518 0.6724
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0033 0.018 0.0344
Loa Loa (eye worm) hypothetical protein 0.0033 0.018 0.0344
Echinococcus multilocularis liprin alpha 2 0.0025 0.009 0.0099
Loa Loa (eye worm) CHromoDomain protein family member 0.0027 0.0111 0.0213
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0129 0.1319 0.1319
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.018 0.0344
Loa Loa (eye worm) hypothetical protein 0.0026 0.0096 0.0183
Onchocerca volvulus 0.0027 0.0104 0.0189
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.1861 0.2054
Plasmodium vivax SET domain protein, putative 0.0061 0.0509 0.3409
Onchocerca volvulus 0.0108 0.1067 0.1941
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0484 0.1504
Brugia malayi excitatory GABA receptor EXP-1A 0.0033 0.018 0.0344
Echinococcus granulosus sterile alpha and tir motif containing protein 0.0025 0.009 0.015
Echinococcus granulosus glycine receptor subunit beta 0.0033 0.018 0.03
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0484 0.0534
Loa Loa (eye worm) LGC-31 protein 0.0033 0.018 0.0344
Loa Loa (eye worm) hypothetical protein 0.0033 0.018 0.0344
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0399 0.0665
Onchocerca volvulus 0.0025 0.009 0.0164
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0025 0.009 0.0172
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0129 0.1319 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0138 0.1419 0.2366
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0033 0.018 0.018
Echinococcus granulosus glycine receptor subunit alpha 1 0.0033 0.018 0.03
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0484 0.0484
Mycobacterium ulcerans beta-lactamase 0.0038 0.0241 0.3749
Loa Loa (eye worm) hypothetical protein 0.0033 0.018 0.0344
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0033 0.0175 0.0659
Onchocerca volvulus 0.0025 0.009 0.0164
Echinococcus multilocularis glycine receptor subunit beta 0.0033 0.018 0.0199
Brugia malayi Carboxylesterase family protein 0.0026 0.0096 0.0183
Brugia malayi intermediate filament protein 0.0027 0.0104 0.0198
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0484 1
Schistosoma mansoni zinc finger protein 0.002 0.0025 0.0025
Trichomonas vaginalis esterase, putative 0.0038 0.0241 0.028
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0484 1
Onchocerca volvulus 0.0025 0.009 0.0164
Echinococcus granulosus intermediate filament protein 0.0027 0.0104 0.0173
Echinococcus multilocularis neuroligin 0.0026 0.0096 0.0106
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0241 0.0564
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0033 0.018 0.0344
Onchocerca volvulus 0.0018 0.0001 0.0002
Brugia malayi Cation transporter family protein 0.0108 0.1067 0.2038
Loa Loa (eye worm) hypothetical protein 0.0026 0.0096 0.0183
Schistosoma mansoni nAChR subunit 0.0033 0.018 0.018
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0153 0.1602 0.1602
Brugia malayi Bromodomain containing protein 0.002 0.0025 0.0048
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0241 1
Onchocerca volvulus 0.0108 0.1067 0.1941
Echinococcus multilocularis pdz domain containing protein 0.0025 0.009 0.0099
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0241 0.0564
Brugia malayi hypothetical protein 0.0025 0.009 0.0172
Schistosoma mansoni jumonji/arid domain-containing protein 0.0094 0.0898 0.0898
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0138 0.1419 0.1419
Brugia malayi F/Y-rich N-terminus family protein 0.0018 0.0001 0.0002
Brugia malayi Shank2E 0.0025 0.009 0.0172
Brugia malayi bicaudal-C 0.0025 0.009 0.0172
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.002 0.0025 0.0028
Echinococcus multilocularis tumor suppressor p53 binding protein 1 0.0329 0.3686 0.4067
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.036 0.0687
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.018 0.0344
Schistosoma mansoni nAChR subunit 0.0033 0.018 0.018
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0424 0.4803 0.918
Brugia malayi Carboxylesterase family protein 0.0153 0.1602 0.3062
Schistosoma mansoni DNAj-like protein 0.0025 0.009 0.009
Schistosoma mansoni BC026374 protein (S09 family) 0.0026 0.0096 0.0096
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0399 0.0572
Echinococcus multilocularis glycine receptor subunit beta 0.0033 0.018 0.0199
Schistosoma mansoni hypothetical protein 0.0329 0.3686 0.3686
Onchocerca volvulus 0.0026 0.0096 0.0175
Onchocerca volvulus 0.0038 0.0241 0.0439
Loa Loa (eye worm) hypothetical protein 0.0033 0.018 0.0344
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0033 0.018 0.0344
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0096 0.0931 0.1552
Echinococcus granulosus glycine receptor subunit alpha 1 0.0033 0.018 0.03
Loa Loa (eye worm) hypothetical protein 0.0026 0.0096 0.0183
Loa Loa (eye worm) hypothetical protein 0.0153 0.1602 0.3062
Loa Loa (eye worm) hypothetical protein 0.0033 0.018 0.0344
Schistosoma mansoni hypothetical protein 0.0025 0.009 0.009
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0241 0.0403
Loa Loa (eye worm) hypothetical protein 0.0038 0.0241 0.0461
Brugia malayi beta-lactamase family protein 0.0038 0.0241 0.0461
Brugia malayi Muscleblind-like protein 0.0315 0.3518 0.6724
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0096 0.0386

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.7079 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of GCN5L2. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504398] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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