Detailed information for compound 1538211

Basic information

Technical information
  • TDR Targets ID: 1538211
  • Name: 3-(3,5-dimethyl-1,2,4-triazol-1-yl)-2-methyl- 1-[4-(2,4,6-trimethylphenyl)sulfonylpiperazin -1-yl]propan-1-one
  • MW: 433.568 | Formula: C21H31N5O3S
  • H donors: 0 H acceptors: 5 LogP: 2.45 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cc(C)c(c(c1)C)S(=O)(=O)N1CCN(CC1)C(=O)C(Cn1nc(nc1C)C)C
  • InChi: 1S/C21H31N5O3S/c1-14-11-15(2)20(16(3)12-14)30(28,29)25-9-7-24(8-10-25)21(27)17(4)13-26-19(6)22-18(5)23-26/h11-12,17H,7-10,13H2,1-6H3
  • InChiKey: BNIQUXOHPPDKNJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 3-(3,5-dimethyl-1,2,4-triazol-1-yl)-2-methyl-1-[4-(2,4,6-trimethylphenyl)sulfonyl-1-piperazinyl]propan-1-one
  • 1-[3-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-2-methylpropanoyl]-4-(mesitylsulfonyl)piperazine
  • AP-124/43383334
  • ASN 14407864

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0015 0.0021 0.0016
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0187 0.1602 1
Loa Loa (eye worm) doublecortin family protein 0.002 0.0067 0.0067
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0616 0.2259
Trypanosoma brucei DNA polymerase IV, putative 0.0079 0.0616 0.2259
Echinococcus granulosus geminin 0.0169 0.1439 0.1435
Loa Loa (eye worm) hypothetical protein 0.0149 0.1255 0.1255
Trypanosoma brucei chrX additional, unordered contigs 0.0016 0.0036 0.006
Loa Loa (eye worm) hypothetical protein 0.0187 0.1602 0.1602
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0066 0.0491 0.0471
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.0751 0.0747
Loa Loa (eye worm) solute carrier family 6 member 4 0.11 1 1
Brugia malayi Heterochromatin protein 1 0.007 0.0524 0.0507
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0021 0.0078 0.0218
Loa Loa (eye worm) hypothetical protein 0.0187 0.1602 0.1602
Brugia malayi jmjC domain containing protein 0.0016 0.0029 0.0011
Mycobacterium leprae Probable phosphoglycerate kinase Pgk 0.017 0.1446 0.358
Echinococcus granulosus solute carrier family 22 0.0015 0.0021 0.0016
Brugia malayi Muscleblind-like protein 0.0149 0.1255 0.124
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.5258 1
Brugia malayi jmjC domain containing protein 0.0059 0.0425 0.0408
Leishmania major phosphoglycerate kinase C, glycosomal 0.017 0.1446 0.5411
Schistosoma mansoni kinase 0.0048 0.0325 0.0306
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0442 0.0438
Echinococcus multilocularis dna polymerase eta 0.0078 0.0606 0.0601
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0184 0.0622
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0442 0.0422
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0078 0.0074
Plasmodium falciparum M17 leucyl aminopeptidase 0.0105 0.0853 0.5264
Echinococcus granulosus leucyl aminopeptidase 0.0021 0.0078 0.0074
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0021 0.0016
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.1196 0.4462
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0062 0.0458 0.1661
Leishmania major DNA polymerase kappa, putative 0.006 0.0432 0.1563
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0066 0.0491 0.0486
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0021
Echinococcus granulosus lamin dm0 0.0027 0.0132 0.0128
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0149 0.1255 0.1255
Brugia malayi hypothetical protein 0.0015 0.0021 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0616 0.2259
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0281 0.099
Echinococcus multilocularis phosphoglycerate kinase 1 0.017 0.1446 0.1442
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0053 0.0372 0.0368
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0442 0.0438
Trypanosoma cruzi DNA polymerase eta, putative 0.0078 0.0606 0.2221
Toxoplasma gondii peptidylprolyl isomerase 0.0033 0.0184 0.1035
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0425 0.0405
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0029 0.0029
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0053 0.0372 0.0372
Trichomonas vaginalis set domain proteins, putative 0.0236 0.2058 0.389
Loa Loa (eye worm) serotonin transporter b 0.11 1 1
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0139 0.0226
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0491 0.1784
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0187 0.1602 0.1598
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0021 0.0016
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0271 0.0477
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.5258 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.1196 0.4462
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0033 0.0191 0.0174
Brugia malayi cytosol aminopeptidase 0.0021 0.0078 0.0061
Echinococcus granulosus dna polymerase kappa 0.0079 0.0616 0.0612
Echinococcus multilocularis solute carrier family 22 0.0015 0.0021 0.0016
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0751 0.1396
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0447 0.1712
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0029
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0447 0.0442
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0021
Leishmania major phosphoglycerate kinase B, cytosolic 0.017 0.1446 0.5411
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0616 0.2259
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0442 0.1693
Plasmodium vivax amine transporter, putative 0.0187 0.1602 1
Loa Loa (eye worm) glutaminase 2 0.0273 0.2392 0.2392
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0021 0.0003
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0105 0.0853 0.316
Schistosoma mansoni sodium-dependent amino acid transporter 0.0187 0.1602 0.1585
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0187 0.1602 0.1585
Loa Loa (eye worm) sugar transporter 0.0015 0.0021 0.0021
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.5258 1
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0751 0.1396
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0021 0.0078 0.0218
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0016 0.0029 0.0024
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0616 0.2259
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0061 0.0447 0.1618
Trichomonas vaginalis chromobox protein, putative 0.007 0.0524 0.0962
Echinococcus granulosus chromobox protein 1 0.007 0.0524 0.052
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0061 0.0447 0.1712
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0159 0.0875
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0442 0.16
Plasmodium falciparum transporter, putative 0.0187 0.1602 1
Echinococcus granulosus transcription factor Dp 1 0.0038 0.0236 0.0231
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0105 0.0853 0.316
Echinococcus multilocularis sodium and chloride dependent glycine 0.0187 0.1602 0.1598
Treponema pallidum fructose-bisphosphate aldolase 0.0585 0.5258 0.4456
Echinococcus multilocularis serotonin transporter 0.11 1 1
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0187 0.1602 0.1598
Schistosoma mansoni DNA polymerase eta 0.0078 0.0606 0.0586
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0016 0.0029 0.0009
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0021
Mycobacterium tuberculosis Probable phosphoglycerate kinase Pgk 0.017 0.1446 0.5727
Echinococcus granulosus phd:f box containing protein 0.0016 0.0029 0.0024
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.0616 0.2259
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0067 0.0062
Trypanosoma brucei polo-like protein kinase 0.0094 0.0751 0.2775
Toxoplasma gondii hypothetical protein 0.0187 0.1602 1
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0067 0.0062
Schistosoma mansoni chromobox protein 0.007 0.0524 0.0505
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0061 0.0447 0.0427
Loa Loa (eye worm) glutaminase 0.0273 0.2392 0.2392
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0042 0.027 0.1576
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.0616 0.2259
Brugia malayi major facilitator superfamily protein 0.0015 0.0021 0.0003
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0281 0.099
Onchocerca volvulus 0.0031 0.0166 0.0146
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.0616 0.2259
Wolbachia endosymbiont of Brugia malayi phosphoglycerate kinase 0.017 0.1446 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0616 0.2259
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0029 0.0029
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0159 0.0139
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.5258 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0018 0.0018
Echinococcus granulosus phosphoglycerate kinase 1 0.017 0.1446 0.1442
Schistosoma mansoni glutaminase 0.0273 0.2392 0.2377
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0021 0.0003
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.1196 0.4462
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0021 0.0078 0.0061
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0067 0.0062
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0021 0.0078 0.0058
Leishmania major DNA polymerase eta, putative 0.0042 0.027 0.0946
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0015 0.0021 0.0016
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.006 0.0432 0.1563
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0187 0.1602 0.1585
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0053 0.0372 0.0368
Brugia malayi hypothetical protein 0.0187 0.1602 0.1587
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0021
Schistosoma mansoni DNA polymerase IV / kappa 0.0016 0.0036 0.0016
Leishmania major DNA polymerase eta, putative 0.0078 0.0606 0.2221
Trypanosoma brucei DNA polymerase IV, putative 0.0079 0.0616 0.2259
Echinococcus granulosus leucyl aminopeptidase 0.0021 0.0078 0.0074
Loa Loa (eye worm) hypothetical protein 0.0187 0.1602 0.1602
Loa Loa (eye worm) hypothetical protein 0.11 1 1
Loa Loa (eye worm) hypothetical protein 0.11 1 1
Onchocerca volvulus 0.0027 0.0132 0.0112
Loa Loa (eye worm) hypothetical protein 0.0031 0.0166 0.0166
Leishmania major DNA damage repair protein, putative 0.0016 0.0036 0.006
Onchocerca volvulus 0.0187 0.1602 0.1585
Trypanosoma cruzi 3-phosphoglycerate kinase, glycosomal 0.0062 0.0458 0.1661
Plasmodium falciparum JmjC domain-containing protein, putative 0.0016 0.0029 0.0054
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0029 0.0009
Trichomonas vaginalis chromobox protein, putative 0.0042 0.0271 0.0477
Schistosoma mansoni lipoxygenase 0.0083 0.0645 0.0625
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.028 0.0985
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0066 0.0491 0.0491
Trypanosoma cruzi DNA polymerase kappa, putative 0.0079 0.0616 0.2259
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0132 0.0115
Schistosoma mansoni microtubule-associated protein tau 0.0689 0.6214 0.6206
Trypanosoma brucei phosphoglycerate kinase 0.0062 0.0458 0.1661
Chlamydia trachomatis phosphoglycerate kinase 0.017 0.1446 0.7916
Giardia lamblia Phosphoglycerate kinase 0.017 0.1446 0.2722
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.5258 1
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0425 0.042
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0021 0.0078 0.0218
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0079 0.0616 0.1137
Loa Loa (eye worm) hypothetical protein 0.0187 0.1602 0.1602
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0187 0.1602 0.1587
Echinococcus multilocularis solute carrier family 22 0.0015 0.0021 0.0016
Echinococcus multilocularis microtubule associated protein 2 0.0689 0.6214 0.6212
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0021
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0016 0.0036 0.0099
Trypanosoma brucei unspecified product 0.0037 0.0221 0.076
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0118 0.0972 0.0967
Entamoeba histolytica phosphoglycerate kinase, putative 0.017 0.1446 0.2487
Loa Loa (eye worm) hypothetical protein 0.0187 0.1602 0.1602
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.006 0.0432 0.1655
Echinococcus multilocularis muscleblind protein 0.0149 0.1255 0.1251
Brugia malayi Phosphoglycerate kinase 0.017 0.1446 0.1431
Echinococcus multilocularis lysine specific demethylase 6a 0.0016 0.0029 0.0024
Trypanosoma brucei phosphoglycerate kinase 0.017 0.1446 0.5411
Trichomonas vaginalis rotamase, putative 0.0033 0.0191 0.0326
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0751 0.1396
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0275 0.0965
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0187 0.1602 0.1585
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0021
Schistosoma mansoni intermediate filament proteins 0.0027 0.0132 0.0112
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0021 0.0078 0.0061
Loa Loa (eye worm) hypothetical protein 0.018 0.1541 0.1541
Brugia malayi jmjC domain containing protein 0.0016 0.0029 0.0011
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0015 0.0021 0.0016
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0021 0.0021
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0021
Schistosoma mansoni lamin 0.0027 0.0132 0.0112
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0066 0.0491 0.1784
Trypanosoma brucei unspecified product 0.0073 0.0555 0.203
Echinococcus multilocularis expressed protein 0.0033 0.0191 0.0187
Echinococcus multilocularis phd:f box containing protein 0.0016 0.0029 0.0024
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0066 0.0491 0.0604
Echinococcus multilocularis sodium and chloride dependent glycine 0.0187 0.1602 0.1598
Brugia malayi polk-prov protein 0.0043 0.028 0.0263
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0376 0.0376
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0187 0.1602 0.1602
Trichomonas vaginalis glutaminase, putative 0.0273 0.2392 0.4528
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0314 0.056
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0021 0.0078 0.0218
Trypanosoma brucei phosphoglycerate kinase, putative 0.0062 0.0458 0.1661
Echinococcus multilocularis RUN 0.002 0.0067 0.0062
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0243 0.0425
Brugia malayi intermediate filament protein 0.0027 0.0132 0.0115
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.036 0.1288
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0132 0.0132
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0286 0.251 1
Echinococcus granulosus serotonin transporter 0.11 1 1
Loa Loa (eye worm) heterochromatin protein 1 0.007 0.0524 0.0524
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0314 0.056
Brugia malayi ImpB/MucB/SamB family protein 0.0053 0.0372 0.0355
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0187 0.1602 0.1585
Onchocerca volvulus 0.002 0.0067 0.0046
Onchocerca volvulus 0.0187 0.1602 0.1585
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0105 0.0853 0.5264
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0015 0.0021 0.0016
Plasmodium falciparum amino acid transporter, putative 0.0187 0.1602 1
Toxoplasma gondii phosphoglycerate kinase PGKII 0.017 0.1446 0.9013
Schistosoma mansoni hypothetical protein 0.0169 0.1439 0.1422
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0491 0.1784
Schistosoma mansoni sodium/chloride dependent transporter 0.0187 0.1602 0.1585
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0021
Brugia malayi major facilitator superfamily protein 0.0015 0.0021 0.0003
Leishmania major mitochondrial DNA polymerase beta 0.0301 0.2655 1
Plasmodium falciparum DNA repair protein REV1, putative 0.0016 0.0036 0.0099
Loa Loa (eye worm) hypothetical protein 0.11 1 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0159 0.0154
Brugia malayi jmjC domain containing protein 0.0016 0.0029 0.0011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0159 0.0139
Brugia malayi Pre-SET motif family protein 0.0208 0.1794 0.1779
Brugia malayi Sugar transporter family protein 0.0015 0.0021 0.0003
Schistosoma mansoni polycystin 1-related 0.002 0.0067 0.0046
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0067 0.0293
Trypanosoma brucei DNA polymerase IV, putative 0.0073 0.0555 0.203
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.018 0.1541 0.1523
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0078 0.0074
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0015 0.0021 0.0016
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0187 0.1602 0.1598
Plasmodium vivax SET domain protein, putative 0.003 0.0159 0.0875
Schistosoma mansoni rab6-interacting 0.002 0.0067 0.0046
Brugia malayi hypothetical protein 0.0015 0.0021 0.0003
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0021 0.0016
Trypanosoma brucei DNA damage repair protein, putative 0.0016 0.0036 0.006
Echinococcus granulosus JmjC domain containing protein 4 0.0016 0.0029 0.0024
Echinococcus multilocularis muscleblind protein 1 0.0149 0.1255 0.1251
Loa Loa (eye worm) norepinephrine transporter 0.11 1 1
Echinococcus granulosus muscleblind protein 0.0149 0.1255 0.1251
Onchocerca volvulus 0.0027 0.0132 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0028 0.0139 0.0226
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0029
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0066 0.0491 0.0486
Treponema pallidum sodium- and chloride- dependent transporter 0.11 1 1
Echinococcus multilocularis jumonji domain containing 1A 0.0016 0.0029 0.0024
Trypanosoma cruzi DNA damage repair protein, putative 0.0016 0.0036 0.006
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0021
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0066 0.0491 0.1784
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.11 1 1
Echinococcus granulosus intermediate filament protein 0.0027 0.0132 0.0128
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0041 0.0264 0.0244
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0021 0.0078 0.0218
Trypanosoma brucei DNA damage repair protein, putative 0.0016 0.0036 0.006
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0286 0.251 1
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0016 0.0029 0.0024
Echinococcus granulosus solute carrier family 22 0.0015 0.0021 0.0016
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.0751 0.0747
Toxoplasma gondii hypothetical protein 0.0049 0.0332 0.1969
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0036 0.006
Schistosoma mansoni phosphatidylserine receptor 0.0016 0.0029 0.0009
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0187 0.1602 0.1587
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0159 0.0154
Schistosoma mansoni phosphoglycerate kinase 0.017 0.1446 0.1428
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0021 0.0078 0.0061
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0585 0.5258 1
Plasmodium vivax phosphoglycerate kinase, putative 0.017 0.1446 0.9013
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0275 0.0965
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0061 0.0447 0.0442
Schistosoma mansoni loxhd1 0.002 0.0067 0.0046
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0023 0.0097 0.0482
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0015 0.0021 0.0016
Echinococcus granulosus sodium and chloride dependent glycine 0.0187 0.1602 0.1598
Echinococcus multilocularis solute carrier family 22 0.0015 0.0021 0.0016
Echinococcus multilocularis chromobox protein 1 0.007 0.0524 0.052
Mycobacterium ulcerans DNA polymerase IV 0.0079 0.0616 0.2391
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0118 0.0972 0.0967
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.5258 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0029
Schistosoma mansoni sodium/chloride dependent transporter 0.0187 0.1605 0.1588
Toxoplasma gondii phosphoglycerate kinase PGKI 0.017 0.1446 0.9013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.5258 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.028 0.028
Trichomonas vaginalis phosphoglycerate kinase, putative 0.017 0.1446 0.2722
Schistosoma mansoni chromobox protein 0.007 0.0524 0.0505
Schistosoma mansoni lamin 0.0027 0.0132 0.0112
Schistosoma mansoni rab6-interacting 0.002 0.0067 0.0046
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0033 0.0184 0.0622
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.0751 0.0732
Mycobacterium ulcerans DNA polymerase IV 0.0079 0.0616 0.2391
Loa Loa (eye worm) hypothetical protein 0.0026 0.0128 0.0128
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.0432 0.1563
Echinococcus multilocularis lamin dm0 0.0027 0.0132 0.0128
Echinococcus multilocularis transcription factor Dp 1 0.0038 0.0236 0.0231
Echinococcus multilocularis lamin 0.0027 0.0132 0.0128
Brugia malayi glutaminase DH11.1 0.0273 0.2392 0.2379
Mycobacterium ulcerans hypothetical protein 0.0016 0.0036 0.0063
Trypanosoma brucei unspecified product 0.0037 0.0221 0.076
Toxoplasma gondii hypothetical protein 0.0187 0.1602 1
Echinococcus granulosus microtubule associated protein 2 0.0689 0.6214 0.6212
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.0751 0.1118
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0015 0.0021 0.0016
Loa Loa (eye worm) sugar transporter 0.0015 0.0021 0.0021
Echinococcus multilocularis chromobox protein 1 0.007 0.0524 0.052
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0442 0.0422
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.0281 0.099
Giardia lamblia Fructose-bisphosphate aldolase 0.0585 0.5258 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0043 0.028 0.0985
Echinococcus granulosus sodium and chloride dependent glycine 0.0187 0.1602 0.1598
Entamoeba histolytica deoxycytidyl transferase, putative 0.0053 0.0372 0.037
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0442 0.1693
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0585 0.5258 1
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0105 0.0853 0.316
Schistosoma mansoni lipoxygenase 0.0118 0.0972 0.0953
Echinococcus granulosus jumonji domain containing 1A 0.0016 0.0029 0.0024
Loa Loa (eye worm) hypothetical protein 0.002 0.0067 0.0067
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0021 0.0016
Leishmania major hypothetical protein, conserved 0.0016 0.0029 0.0032
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0187 0.1602 0.1585
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0425 0.042
Echinococcus multilocularis leucine aminopeptidase protein 0.0105 0.0853 0.0849
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0187 0.1602 0.1602
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0021 0.0078 0.0078
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0187 0.1602 0.1585
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0033 0.0184 0.0622
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0425 0.042
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0208 0.1794 0.1794
Echinococcus multilocularis solute carrier family 22 0.0015 0.0021 0.0016
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0301 0.2655 1
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0105 0.0853 0.584
Brugia malayi hypothetical protein 0.0015 0.0021 0.0003
Echinococcus multilocularis JmjC domain containing protein 4 0.0016 0.0029 0.0024
Echinococcus granulosus solute carrier family 22 0.0015 0.0021 0.0016
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0067 0.0062
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0425 0.0405
Brugia malayi Phosphoglycerate kinase 0.0062 0.0458 0.0441
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0105 0.0853 0.316
Echinococcus granulosus dna polymerase eta 0.0078 0.0606 0.0601
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0015 0.0021 0.0016
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0066 0.0491 0.0474
Loa Loa (eye worm) hypothetical protein 0.003 0.0159 0.0159
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0187 0.1602 0.1585
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0021 0.0078 0.0078
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0053 0.0372 0.0352
Trichomonas vaginalis chromobox protein, putative 0.007 0.0524 0.0962
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0751 0.1396
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0021 0.0078 0.0218
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0029 0.0032
Echinococcus granulosus leucine aminopeptidase protein 0.0105 0.0853 0.0849
Echinococcus granulosus solute carrier family 22 0.0015 0.0021 0.0016
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0016 0.0029 0.0054
Onchocerca volvulus 0.0187 0.1602 0.1585
Schistosoma mansoni terminal deoxycytidyl transferase 0.0053 0.0372 0.0352
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0021 0.0003
Loa Loa (eye worm) hypothetical protein 0.0027 0.0132 0.0132
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0286 0.251 1
Onchocerca volvulus 0.11 1 1
Loa Loa (eye worm) hypothetical protein 0.0187 0.1602 0.1602
Schistosoma mansoni hypothetical protein 0.0169 0.1439 0.1422
Mycobacterium tuberculosis Conserved hypothetical protein 0.0053 0.0372 0.1412
Brugia malayi Doublecortin family protein 0.002 0.0067 0.0049
Echinococcus multilocularis musashi 0.0027 0.0132 0.0128
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0187 0.1602 1
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0187 0.1602 0.1587
Mycobacterium ulcerans glutaminase 0.0273 0.2392 0.9528
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0187 0.1602 0.1587
Trypanosoma brucei phosphoglycerate kinase 0.017 0.1446 0.5411
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0243 0.0223
Leishmania major PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.0458 0.1661
Trypanosoma cruzi phosphoglycerate kinase, putative 0.017 0.1446 0.5411
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0187 0.1602 0.1598
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0585 0.5258 1
Mycobacterium ulcerans hypothetical protein 0.0159 0.1344 0.5317
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0187 0.1602 0.1585
Loa Loa (eye worm) hypothetical protein 0.0039 0.0243 0.0243
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0021
Plasmodium vivax hypothetical protein, conserved 0.0187 0.1602 1
Onchocerca volvulus 0.0236 0.2058 0.2041
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0275 0.0965
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.0447 0.043
Trypanosoma cruzi DNA polymerase eta, putative 0.0042 0.027 0.0946
Plasmodium falciparum phosphoglycerate kinase 0.017 0.1446 0.9013
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0021 0.0078 0.0074
Loa Loa (eye worm) hypothetical protein 0.0078 0.0606 0.0606
Echinococcus granulosus RUN 0.002 0.0067 0.0062
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0067 0.0293
Trichomonas vaginalis rotamase, putative 0.0033 0.0184 0.0313
Mycobacterium ulcerans phosphoglycerate kinase 0.017 0.1446 0.5727
Brugia malayi Sugar transporter family protein 0.0015 0.0021 0.0003
Giardia lamblia DINP protein human, muc B family 0.006 0.0432 0.0786
Schistosoma mansoni rotamase 0.0033 0.0191 0.0171
Brugia malayi chromobox protein homolog 3 0.0039 0.0243 0.0226
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0187 0.1602 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0442 0.1693
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0187 0.1602 0.1598
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0105 0.0853 0.3344
Loa Loa (eye worm) jmjC domain-containing protein 0.0016 0.0029 0.0029
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0616 0.2259
Echinococcus multilocularis dna polymerase kappa 0.0079 0.0616 0.0612
Loa Loa (eye worm) hypothetical protein 0.0013 0.0005 0.0005
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.0751 0.0735
Onchocerca volvulus 0.0041 0.0264 0.0244
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0616 0.2259
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0275 0.0965
Trypanosoma cruzi phosphoglycerate kinase, putative 0.0062 0.0458 0.1661
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0021 0.0078 0.0218
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.0458 0.1661
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0425 0.042
Echinococcus granulosus expressed protein 0.0033 0.0191 0.0187
Trypanosoma cruzi phosphoglycerate kinase, putative 0.017 0.1446 0.5411
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.1344 0.5317
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0191 0.0326
Brugia malayi jmjC domain containing protein 0.0016 0.0029 0.0011
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0061 0.0447 0.1712
Echinococcus granulosus lysine specific demethylase 6a 0.0016 0.0029 0.0024
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0132 0.0132
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0187 0.1602 0.1598
Giardia lamblia Kinase, PLK 0.0094 0.0751 0.1396
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0016 0.0029 0.0054
Brugia malayi hypothetical protein 0.002 0.0067 0.0049
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0021
Trichomonas vaginalis phosphoglycerate kinase, putative 0.017 0.1446 0.2722
Brugia malayi ImpB/MucB/SamB family protein 0.0078 0.0606 0.0589
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0425 0.0425
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0159 0.0154
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0751 0.1396
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0016 0.0029 0.0032
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0442 0.2665
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0616 0.2259
Brugia malayi Sugar transporter family protein 0.0015 0.0021 0.0003
Trypanosoma cruzi PAS-domain containing phosphoglycerate kinase, putative 0.0062 0.0458 0.1661
Loa Loa (eye worm) hypothetical protein 0.0015 0.0021 0.0021
Brugia malayi hypothetical protein 0.002 0.0067 0.0049
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.0751 0.2775
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0751 0.1396
Trypanosoma brucei aminopeptidase, putative 0.0021 0.0078 0.0218
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0301 0.2655 1
Schistosoma mansoni protein phosphatase 2C 0.0016 0.0029 0.0009
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0016 0.0029 0.0032
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0187 0.1602 1
Plasmodium vivax DNA repair protein REV1, putative 0.0016 0.0036 0.0099
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0149 0.0144
Schistosoma mansoni sodium/chloride dependent transporter 0.11 1 1
Brugia malayi jmjC domain containing protein 0.0059 0.0425 0.0408
Loa Loa (eye worm) hypothetical protein 0.017 0.1446 0.1446
Plasmodium vivax JmjC domain containing protein 0.0016 0.0029 0.0054
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0425 0.0405
Echinococcus granulosus lamin 0.0027 0.0132 0.0128
Trichomonas vaginalis DNA polymerase eta, putative 0.0079 0.0616 0.1137
Trypanosoma brucei DNA polymerase kappa, putative 0.0079 0.0616 0.2259
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0021 0.0021
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0442 0.1693
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0159 0.0139
Echinococcus granulosus chromobox protein 1 0.007 0.0524 0.052
Giardia lamblia DNA damage repair protein 0.0016 0.0036 0.003
Mycobacterium ulcerans leucyl aminopeptidase 0.0105 0.0853 0.3344
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0243 0.0425
Echinococcus granulosus Solute carrier family 22 5 0.1037 0.9419 0.9419
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0067 0.0062
Schistosoma mansoni hypothetical protein 0.002 0.0067 0.0046
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0033 0.0191 0.0191
Echinococcus multilocularis leucyl aminopeptidase 0.0021 0.0078 0.0074
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0036 0.006
Onchocerca volvulus 0.002 0.0067 0.0046
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.0751 0.1396
Schistosoma mansoni phosphoglycerate kinase 0.017 0.1446 0.1428
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0187 0.1602 0.1598
Loa Loa (eye worm) hypothetical protein 0.0187 0.1602 0.1602
Toxoplasma gondii leucyl aminopeptidase LAP 0.0105 0.0853 0.5264
Trypanosoma brucei hypothetical protein, conserved 0.0016 0.0036 0.006
Echinococcus multilocularis geminin 0.0169 0.1439 0.1435
Trypanosoma cruzi DNA damage repair protein, putative 0.0016 0.0036 0.006
Brugia malayi Pre-SET motif family protein 0.003 0.0159 0.0142
Schistosoma mansoni phd/f-box containing protein 0.0016 0.0029 0.0009
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0751 0.2775
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0033 0.0184 0.0622
Brugia malayi N-terminal motif family protein 0.018 0.1541 0.1526
Trypanosoma brucei DNA polymerase eta, putative 0.0078 0.0606 0.2221
Schistosoma mansoni leucine aminopeptidase 0.0021 0.0078 0.0058
Leishmania major DNA polymerase kappa, putative 0.0016 0.0036 0.006
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0301 0.2655 1
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0067 0.0062
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.0271 0.0251
Trypanosoma cruzi hypothetical protein, conserved 0.0016 0.0036 0.006
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.0751 0.0732
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.0751 0.0751
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.0751 0.2775

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 14.7157 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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