Detailed information for compound 1542831

Basic information

Technical information
  • TDR Targets ID: 1542831
  • Name: 1-[3-(4-chlorophenyl)-5-furan-2-yl-4,5-dihydr opyrazol-1-yl]-2-[4-(1,1-dioxothiolan-3-yl)pi perazin-1-yl]ethanone
  • MW: 491.003 | Formula: C23H27ClN4O4S
  • H donors: 0 H acceptors: 3 LogP: 1.88 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)C1=NN(C(C1)c1ccco1)C(=O)CN1CCN(CC1)C1CCS(=O)(=O)C1
  • InChi: 1S/C23H27ClN4O4S/c24-18-5-3-17(4-6-18)20-14-21(22-2-1-12-32-22)28(25-20)23(29)15-26-8-10-27(11-9-26)19-7-13-33(30,31)16-19/h1-6,12,19,21H,7-11,13-16H2
  • InChiKey: AHQLMSVJNPUBGJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-[3-(4-chlorophenyl)-5-(2-furyl)-4,5-dihydropyrazol-1-yl]-2-[4-(1,1-dioxothiolan-3-yl)piperazin-1-yl]ethanone
  • 1-[3-(4-chlorophenyl)-5-(2-furyl)-4,5-dihydropyrazol-1-yl]-2-[4-(1,1-dioxo-3-thiolanyl)-1-piperazinyl]ethanone
  • 1-[3-(4-chlorophenyl)-5-(2-furyl)-4,5-dihydropyrazol-1-yl]-2-[4-(1,1-diketothiolan-3-yl)piperazin-1-yl]ethanone
  • T5600971

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens GNAS complex locus Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Echinococcus granulosus guanine nucleotide binding protein Gs subunit Get druggable targets OG5_131088 All targets in OG5_131088
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative Get druggable targets OG5_131088 All targets in OG5_131088
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative Get druggable targets OG5_131088 All targets in OG5_131088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain Get druggable targets OG5_131088 All targets in OG5_131088
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) Get druggable targets OG5_131088 All targets in OG5_131088
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Schistosoma mansoni GTP-binding protein alpha subunit gna GNAS complex locus 394 aa 450 aa 28.7 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0.0076 0.2785
Echinococcus granulosus Upstream activation factor subunit UAF30 0.1192 0.4562 0.4562
Entamoeba histolytica cysteine proteinase, putative 0.0025 0.0031 0.2677
Loa Loa (eye worm) cytochrome P450 family protein 0.0038 0.008 0.0173
Brugia malayi hypothetical protein 0.0036 0.0073 0.0161
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0073 0.0072
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0037 0.0079 0.0173
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0022 0.0017 0.0038
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0073 0.0124
Brugia malayi Hypothetical RING finger protein C16C10.7 in chromosome III 0.0022 0.0017 0.0038
Entamoeba histolytica hypothetical protein 0.0032 0.0059 0.6068
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0017 0.0056
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0017 0.0056
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0061 0.0168 0.6337
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.013 0.044 0.2745
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0143 0.0488 0.3051
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Trypanosoma brucei UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0032 0.0059 0.1282
Plasmodium falciparum zinc finger Ran-binding domain-containing protein 2, putative 0.0424 0.158 0.3451
Entamoeba histolytica zinc finger domain containing protein 0.0022 0.0017 0.1052
Plasmodium falciparum zinc finger protein, putative 0.0022 0.0017 0.0019
Trypanosoma cruzi cysteine peptidase, putative 0.0143 0.0488 0.3051
Trypanosoma cruzi cytochrome P450, putative 0.0038 0.008 0.0456
Loa Loa (eye worm) acyl carrier protein 0.0026 0.0035 0.0074
Giardia lamblia Ribonuclease 0.0022 0.0017 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0073 0.012
Trypanosoma cruzi cysteine peptidase, putative 0.0037 0.0079 0.0449
Onchocerca volvulus 0.0424 0.158 0.3438
Schistosoma mansoni peter pan-related 0.0022 0.0017 0.0028
Brugia malayi cathepsin L-like precursor 0.0025 0.0031 0.0067
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0035
Entamoeba histolytica cysteine protease, putative 0.0037 0.0079 0.8414
Echinococcus multilocularis RING finger protein 185 0.0022 0.0017 0.0016
Brugia malayi Pre-SET motif family protein 0.0036 0.0073 0.0161
Echinococcus multilocularis neuropeptide receptor A26 0.0512 0.1922 0.1921
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0331 0.054
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0136 0.0461 0.2918
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Leishmania major cathepsin L-like protease 0.0037 0.0079 0.0499
Trypanosoma cruzi major cysteine proteinase, putative 0.0112 0.0369 0.2296
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Loa Loa (eye worm) hypothetical protein 0.0334 0.1232 0.2697
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Giardia lamblia Protein 21.1 0.0022 0.0017 1
Giardia lamblia Protein 21.1 0.0022 0.0017 1
Schistosoma mansoni transcription factor LCR-F1 0.0032 0.0059 0.0097
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0046 0.0111 0.4155
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0068 0.0067
Schistosoma mansoni mind bomb 0.0022 0.0017 0.0028
Echinococcus granulosus E3 ubiquitin protein ligase Bre1 0.0022 0.0017 0.0016
Giardia lamblia Hypothetical protein 0.0022 0.0017 1
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1192 0.4562 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0136 0.0461 0.046
Schistosoma mansoni TRABID protein (C64 family) 0.0424 0.158 0.2579
Brugia malayi Calcitonin receptor-like protein seb-1 0.0055 0.0148 0.0324
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0143 0.0488 0.3051
Echinococcus multilocularis muscleblind protein 0.0334 0.1232 0.1231
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0073 0.012
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0098 0.0215
Trypanosoma brucei hypothetical protein, conserved 0.0424 0.158 1
Brugia malayi Cathepsin L-like precursor 0.0037 0.0079 0.0173
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0079 0.0173
Leishmania major cathepsin L-like protease 0.0037 0.0079 0.0499
Brugia malayi hypothetical protein 0.0022 0.0017 0.0038
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0079 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Loa Loa (eye worm) cysteine protease 0.0037 0.0079 0.017
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0092 0.1976
Giardia lamblia Hypothetical protein 0.0022 0.0017 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0102 0.0331 0.0723
Schistosoma mansoni hypothetical protein 0.0032 0.0059 0.0097
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0035
Onchocerca volvulus 0.0424 0.158 0.3438
Schistosoma mansoni hypothetical protein 0.0017 0.0001 0.0002
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0038 0.008 0.171
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0424 0.158 0.3463
Giardia lamblia Protein 21.1 0.0022 0.0017 1
Leishmania major hypothetical protein, conserved 0.0022 0.0017 0.0109
Loa Loa (eye worm) RING finger protein 20 0.0022 0.0017 0.0035
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0079 0.0173
Brugia malayi Cathepsin L-like cysteine proteinase 0.0025 0.0031 0.0067
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0079 0.0173
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0079 0.8414
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Schistosoma mansoni voltage-gated potassium channel 0.005 0.0126 0.0205
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0061 0.0168 0.365
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0143 0.0488 0.3051
Entamoeba histolytica zinc finger domain containing protein 0.0022 0.0017 0.1052
Plasmodium vivax vivapain-2 0.0037 0.0079 0.0155
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0008 0.0018
Entamoeba histolytica hypothetical protein 0.0022 0.0017 0.1052
Schistosoma mansoni cellular tumor antigen P53 0.038 0.1407 0.2296
Echinococcus granulosus muscleblind protein 0.0334 0.1232 0.1231
Brugia malayi Cathepsin L-like precursor 0.0037 0.0079 0.0173
Chlamydia trachomatis DNA topoisomerase I 0.1192 0.4562 0.5
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0061 0.0168 0.3631
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0079 0.0173
Echinococcus granulosus E3 ubiquitin protein ligase mib1 0.0022 0.0017 0.0016
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Giardia lamblia Protein 21.1 0.0022 0.0017 1
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0045 0.0109 0.0108
Leishmania major hypothetical protein, conserved 0.0022 0.0017 0.0109
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0092 0.0534
Giardia lamblia Protein 21.1 0.0022 0.0017 1
Schistosoma mansoni hypothetical protein 0.0025 0.0031 0.005
Leishmania major hypothetical protein, conserved 0.0022 0.0017 0.0109
Brugia malayi RING zinc finger protein 0.0022 0.0017 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Plasmodium falciparum SWIB/MDM2 domain-containing protein 0.1192 0.4562 1
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0092 0.0534
Brugia malayi Pre-SET motif family protein 0.0251 0.0909 0.1992
Schistosoma mansoni hypothetical protein 0.0038 0.008 0.013
Brugia malayi Zinc finger, C2H2 type family protein 0.0022 0.0017 0.0038
Loa Loa (eye worm) RiNg Finger protein family member 0.0022 0.0018 0.0037
Echinococcus granulosus RING finger and transmembrane domain containing protein 0.0022 0.0017 0.0016
Giardia lamblia Protein 21.1 0.0022 0.0017 1
Loa Loa (eye worm) hypothetical protein 0.0424 0.158 0.3461
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0424 0.158 0.3463
Echinococcus granulosus Zinc finger RanBP2 type 0.0424 0.158 0.1579
Plasmodium vivax E3 ubiquitin-protein ligase, putative 0.0022 0.0017 0.0019
Mycobacterium ulcerans polyketide synthase 0.0061 0.0168 0.3631
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0331 0.054
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0085 0.0264 0.5724
Toxoplasma gondii LsmAD domain-containing protein 0.0056 0.015 0.0293
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0008 0.0018
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0037 0.0079 0.0173
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0037 0.0079 0.0155
Mycobacterium ulcerans fatty acid synthase Fas 0.0018 0.0003 0.0032
Echinococcus granulosus cathepsin l1 0.0025 0.0031 0.003
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Brugia malayi brahma associated protein 60 kDa 0.1192 0.4562 1
Brugia malayi hypothetical protein 0.0022 0.0017 0.0038
Echinococcus granulosus E3 ubiquitin protein ligase LRSAM1 0.0022 0.0017 0.0016
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0022 0.0017 0.0056
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0032 0.0059 0.0058
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Schistosoma mansoni fusion 0.0424 0.158 0.2579
Onchocerca volvulus 0.0037 0.0079 0.0136
Schistosoma mansoni hypothetical protein 0.1192 0.4562 0.7446
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0017 0.0001 0.0003
Loa Loa (eye worm) hypothetical protein 0.0039 0.0086 0.0186
Giardia lamblia Protein 21.1 0.0022 0.0017 1
Plasmodium falciparum E3 ubiquitin-protein ligase, putative 0.0022 0.0017 0.0019
Toxoplasma gondii ran binding protein 0.0424 0.158 0.3438
Trypanosoma cruzi hypothetical protein, conserved 0.0424 0.158 1
Trypanosoma brucei cytochrome P450, putative 0.0038 0.008 0.0456
Onchocerca volvulus Ubiquitin thioesterase ZRANB1 homolog 0.0424 0.158 0.3438
Echinococcus granulosus cell growth regulator with ring finger domain 0.0022 0.0017 0.0016
Brugia malayi Cathepsin L-like precursor 0.0037 0.0079 0.0173
Echinococcus multilocularis E3 ubiquitin protein ligase LRSAM1 0.0022 0.0017 0.0016
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0038 0.008 0.1702
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.0008 0.0014
Echinococcus multilocularis E3 ubiquitin protein ligase Bre1 0.0022 0.0017 0.0016
Schistosoma mansoni rnf5 0.0022 0.0017 0.0028
Echinococcus multilocularis cysteine protease 0.0037 0.0079 0.0078
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0079 0.0173
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0073 0.012
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0143 0.0488 0.3051
Echinococcus granulosus ring and YY1 binding protein 0.0424 0.158 0.1579
Leishmania major hypothetical protein 0.0022 0.0017 0.0109
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.0065
Trichomonas vaginalis cell cycle control protein cwf24, putative 0.0022 0.0018 0.0039
Leishmania major hypothetical protein, conserved 0.0424 0.158 1
Plasmodium falciparum RING zinc finger protein, putative 0.0022 0.0017 0.0019
Schistosoma mansoni hypothetical protein 0.0017 0.0001 0.0002
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0031 0.0067
Plasmodium vivax ataxin-2 like protein, putative 0.0056 0.015 0.0311
Onchocerca volvulus Cathepsin F homolog 0.0037 0.0079 0.0136
Echinococcus granulosus cathepsin L cysteine proteinase 0.0037 0.0079 0.0078
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0061 0.0168 0.365
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Loa Loa (eye worm) hypothetical protein 0.0037 0.0079 0.017
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0022 0.0017 0.0038
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0092 0.0202
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0053 0.014 0.3037
Trypanosoma cruzi cysteine peptidase, putative 0.0143 0.0488 0.3051
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.0065
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Schistosoma mansoni inositol monophosphatase 0.0041 0.0092 0.015
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0136 0.0461 1
Echinococcus granulosus neuropeptide receptor A26 0.0512 0.1922 0.1921
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.015 0.0902
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger) containing protein, putative 0.0022 0.0017 0.0056
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0055 0.0148 0.3205
Giardia lamblia Kinase, NEK 0.0022 0.0017 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0079 0.0173
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0092 0.0165
Chlamydia trachomatis SWIB complex protein 0.1192 0.4562 0.5
Schistosoma mansoni hypothetical protein 0.1192 0.4562 0.7446
Trypanosoma brucei Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Entamoeba histolytica zinc finger domain containing protein 0.0022 0.0017 0.1052
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0035
Mycobacterium ulcerans polyketide synthase 0.0057 0.0155 0.3332
Echinococcus granulosus E3 ubiquitin protein ligase MYLIP 0.0022 0.0017 0.0016
Schistosoma mansoni brg-1 associated factor 0.1192 0.4562 0.7446
Giardia lamblia Protein 21.1 0.0022 0.0017 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0018
Trichomonas vaginalis inositol monophosphatase, putative 0.0041 0.0092 0.0202
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0057 0.0155 0.3352
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0424 0.158 0.3463
Leishmania major hypothetical protein, conserved 0.0424 0.158 1
Schistosoma mansoni cathepsin F (C01 family) 0.0025 0.0031 0.005
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0053 0.014 0.0304
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0092 0.5
Brugia malayi Latrophilin receptor protein 2 0.0017 0.0001 0.0003
Onchocerca volvulus 0.0053 0.014 0.027
Brugia malayi Cathepsin L-like precursor 0.0037 0.0079 0.0173
Echinococcus multilocularis ring finger protein 170 0.0022 0.0017 0.0016
Mycobacterium leprae Probable polyketide synthase Pks1 0.0061 0.0168 0.6337
Giardia lamblia Protein 21.1 0.0022 0.0017 1
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0061 0.0168 0.365
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0037 0.0079 0.017
Onchocerca volvulus Cathepsin L homolog 0.0037 0.0079 0.0136
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0102 0.0331 0.0725
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Giardia lamblia Hypothetical protein 0.0022 0.0017 1
Trypanosoma cruzi WLM domain containing protein, putative 0.0424 0.158 1
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0061 0.0168 0.3631
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0143 0.0488 0.3051
Echinococcus granulosus cathepsin L 0.0019 0.0008 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0017 0.0056
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0037 0.0079 0.0155
Giardia lamblia Protein 21.1 0.0022 0.0017 1
Onchocerca volvulus 0.1192 0.4562 1
Echinococcus multilocularis SWI:SNF matrix associated 0.1192 0.4562 0.4562
Schistosoma mansoni voltage-gated potassium channel 0.005 0.0126 0.0205
Echinococcus granulosus ring finger protein 170 0.0022 0.0017 0.0016
Schistosoma mansoni hypothetical protein 0.0017 0.0001 0.0002
Trichomonas vaginalis hypothetical protein 0.0022 0.0017 0.0038
Onchocerca volvulus 0.0037 0.0079 0.0136
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0143 0.0488 0.3051
Entamoeba histolytica hypothetical protein 0.0032 0.0059 0.6068
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.0461 1
Leishmania major hypothetical protein, conserved 0.0022 0.0017 0.0109
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.0461 1
Loa Loa (eye worm) hypothetical protein 0.0334 0.1232 0.2697
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0143 0.0488 0.3051
Giardia lamblia Protein 21.1 0.0022 0.0017 1
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0045 0.0109 0.024
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0143 0.0488 0.3051
Echinococcus multilocularis tumor protein p63 0.2593 1 1
Onchocerca volvulus 0.0037 0.0079 0.0136
Loa Loa (eye worm) hypothetical protein 0.0036 0.0073 0.0158
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0136 0.0461 0.046
Brugia malayi brahma associated protein 60 kDa 0.1192 0.4562 1
Entamoeba histolytica hypothetical protein 0.0032 0.0059 0.6068
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Loa Loa (eye worm) hypothetical protein 0.0038 0.008 0.0173
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0023 0.0023 0.0495
Toxoplasma gondii DNA topoisomerase domain-containing protein 0.1192 0.4562 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0022 0.0017 0.0038
Schistosoma mansoni zinc finger protein 0.0022 0.0017 0.0028
Echinococcus multilocularis Nuclear pore complex protein Nup153 0.0424 0.158 0.1579
Leishmania major hypothetical protein, conserved 0.0424 0.158 1
Brugia malayi RING finger protein 20 0.0022 0.0017 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0057 0.0155 0.0339
Toxoplasma gondii Zn-finger in Ran binding protein and others domain-containing protein 0.0424 0.158 0.3438
Trypanosoma brucei Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0424 0.158 1
Entamoeba histolytica SPRY domain protein 0.0022 0.0017 0.1052
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0143 0.0488 0.3051
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0008 0.0018
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0035
Schistosoma mansoni hypothetical protein 0.0022 0.0017 0.0028
Leishmania major hypothetical protein, conserved 0.0022 0.0017 0.0109
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0035
Schistosoma mansoni aldehyde dehydrogenase 0.0136 0.0461 0.0753
Plasmodium vivax E3 ubiquitin-protein ligase RNF5, putative 0.0022 0.0017 0.0019
Schistosoma mansoni RNA binding protein 0.0424 0.158 0.2579
Schistosoma mansoni microtubule-associated protein tau 0.1595 0.6127 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0079 0.0173
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0092 0.0583
Plasmodium falciparum cysteine proteinase falcipain 3 0.0037 0.0079 0.0155
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0032 0.0059 0.0058
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0022 0.0017 0.0038
Entamoeba histolytica zinc finger domain containing protein 0.0022 0.0017 0.1052
Giardia lamblia Protein 21.1 0.0022 0.0017 1
Toxoplasma gondii SWIB/MDM2 domain-containing protein 0.1192 0.4562 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0055 0.0148 0.0321
Echinococcus granulosus RING finger protein 185 0.0022 0.0017 0.0016
Giardia lamblia Kinase 0.0022 0.0017 1
Loa Loa (eye worm) hypothetical protein 0.0424 0.158 0.3461
Trypanosoma cruzi hypothetical protein 0.0022 0.0017 0.0056
Giardia lamblia Protein 21.1 0.0022 0.0017 1
Schistosoma mansoni inhibitor of apoptosis 1 diap1 0.0022 0.0017 0.0028
Trypanosoma cruzi cruzipain precursor, putative 0.0143 0.0488 0.3051
Brugia malayi Cathepsin L-like precursor 0.0037 0.0079 0.0173
Leishmania major DNA repair protein-like protein 0.0022 0.0017 0.0109
Onchocerca volvulus 0.0037 0.0079 0.0136
Brugia malayi AMP-binding enzyme family protein 0.0053 0.014 0.0307
Leishmania major cathepsin L-like protease 0.0037 0.0079 0.0499
Schistosoma mansoni aldehyde dehydrogenase 0.0136 0.0461 0.0753
Echinococcus multilocularis Zinc finger, RanBP2 type 0.0424 0.158 0.1579
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0079 0.0173
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0017 0.0056
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Giardia lamblia Protein 21.1 0.0022 0.0017 1
Toxoplasma gondii aldehyde dehydrogenase 0.0136 0.0461 0.0977
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.0331 0.033
Plasmodium vivax zinc finger protein, putative 0.0022 0.0017 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0035
Echinococcus granulosus SWI:SNF matrix associated 0.1192 0.4562 0.4562
Loa Loa (eye worm) hypothetical protein 0.0032 0.0057 0.0123
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0037 0.0079 0.017
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.1192 0.4562 0.4562
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0079 0.0173
Brugia malayi Cathepsin L-like precursor 0.0025 0.0031 0.0067
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.0331 0.033
Trichomonas vaginalis ankyrin, putative 0.0022 0.0017 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Mycobacterium ulcerans thioesterase TesA 0.0047 0.0118 0.253
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Brugia malayi hypothetical protein 0.0032 0.0059 0.013
Echinococcus granulosus zinc finger protein Ran binding 0.0424 0.158 0.1579
Echinococcus granulosus cysteine protease 0.0019 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.038 0.1407 0.3082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0079 0.0173
Trypanosoma cruzi Zn-finger in Ran binding protein and others/FYVE zinc finger, putative 0.0424 0.158 1
Giardia lamblia Zinc finger domain 0.0022 0.0017 1
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Loa Loa (eye worm) inositol-1 0.0041 0.0092 0.0199
Echinococcus multilocularis cathepsin L 0.0019 0.0008 0.0007
Trypanosoma cruzi hypothetical protein, conserved 0.0424 0.158 1
Leishmania major cathepsin L-like protease 0.0037 0.0079 0.0499
Giardia lamblia Protein 21.1 0.0022 0.0017 1
Onchocerca volvulus 0.038 0.1407 0.3057
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0424 0.158 1
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0017 0.0056
Schistosoma mansoni zinc finger protein 0.0424 0.158 0.2579
Echinococcus multilocularis cysteine protease 0.0037 0.0079 0.0078
Trypanosoma brucei DNA repair protein, putative 0.0022 0.0017 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0079 0.0173
Brugia malayi Muscleblind-like protein 0.0334 0.1232 0.2699
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0079 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0025 0.0031 0.0067
Leishmania major hypothetical protein, conserved 0.0022 0.0017 0.0109
Leishmania major cathepsin L-like protease 0.0143 0.0488 0.3087
Trichomonas vaginalis ankyrin, putative 0.0022 0.0017 0.0038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0102 0.0331 0.054
Onchocerca volvulus 0.0037 0.0079 0.0136
Trypanosoma cruzi cysteine peptidase, putative 0.0143 0.0488 0.3051
Giardia lamblia Protein 21.1 0.0022 0.0017 1
Trypanosoma brucei mitochondrial RNA binding complex 1 subunit 0.0424 0.158 1
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0035
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Schistosoma mansoni inositol monophosphatase 0.0041 0.0092 0.015
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0143 0.0488 0.3051
Giardia lamblia Zinc finger domain 0.0022 0.0017 1
Giardia lamblia Protein 21.1 0.0022 0.0017 1
Giardia lamblia Protein 21.1 0.0022 0.0017 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0102 0.0331 0.033
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0038 0.008 0.2941
Onchocerca volvulus 0.0025 0.0031 0.003
Mycobacterium ulcerans Type I modular polyketide synthase 0.0057 0.0155 0.3332
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0073 0.012
Brugia malayi Cathepsin L-like precursor 0.0037 0.0079 0.0173
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0102 0.0331 0.033
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.1192 0.4562 1
Schistosoma mansoni ring finger protein 151 0.0022 0.0017 0.0028
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Plasmodium vivax SWIB/MDM2 domain-containing protein, putative 0.1192 0.4562 1
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0061 0.0168 0.6337
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0079 0.0173
Echinococcus granulosus Nuclear pore complex protein Nup153 0.0424 0.158 0.1579
Plasmodium vivax trophozoite exported protein 1, putative 0.0022 0.0017 0.0019
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.0008 0.0014
Toxoplasma gondii type I fatty acid synthase, putative 0.0061 0.0168 0.0332
Leishmania major cathepsin L-like protease 0.0037 0.0079 0.0499
Entamoeba histolytica cysteine proteinase, putative 0.0037 0.0079 0.8414
Schistosoma mansoni hypothetical protein 0.0017 0.0001 0.0002
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0045 0.0109 0.0237
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.0079 0.0129
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0092 0.0534
Echinococcus multilocularis neuropeptide s receptor 0.0512 0.1922 0.1921
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0079 0.0173
Echinococcus granulosus ring finger protein 113a 0.0022 0.0018 0.0017
Onchocerca volvulus Fatty acid synthase homolog 0.0103 0.0332 0.0693
Brugia malayi Cathepsin L-like precursor 0.0025 0.0031 0.0067
Schistosoma mansoni hypothetical protein 0.0022 0.0017 0.0028
Leishmania major cathepsin L-like protease 0.0143 0.0488 0.3087
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Loa Loa (eye worm) hypothetical protein 0.0056 0.015 0.0327
Leishmania major hypothetical protein, conserved 0.0424 0.158 1
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0042 0.0098 0.0215
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0025 0.0031 0.0029
Echinococcus granulosus cathepsin l1 0.0037 0.0079 0.0078
Brugia malayi AMP-binding enzyme family protein 0.0018 0.0001 0.0003
Brugia malayi SWIB/MDM2 domain containing protein 0.1192 0.4562 1
Plasmodium vivax SET domain protein, putative 0.0036 0.0073 0.0143
Trichomonas vaginalis set domain proteins, putative 0.0286 0.1044 0.2288
Brugia malayi B-box zinc finger family protein 0.0022 0.0017 0.0038
Giardia lamblia Protein 21.1 0.0022 0.0017 1
Leishmania major hypothetical protein, conserved 0.0022 0.0017 0.0109
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0079 0.0173
Giardia lamblia Hypothetical protein 0.0022 0.0017 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0055 0.0148 0.0324
Giardia lamblia Protein 21.1 0.0022 0.0017 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0037 0.0079 0.0078
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0018 0.0003 0.0062
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0092 0.0091
Trypanosoma brucei predicted zinc finger protein 0.0022 0.0017 0.0056
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0041 0.0092 0.2001
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0017 0.0056
Leishmania major hypothetical protein, conserved 0.0022 0.0017 0.0109
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger)/EF-hand domain pair, putative 0.0022 0.0017 0.0056
Plasmodium vivax DNA repair protein RAD5, putative 0.0022 0.0017 0.0019
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Brugia malayi hypothetical protein 0.0022 0.0017 0.0038
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Echinococcus granulosus cathepsin L cysteine protease 0.0019 0.0008 0.0007
Schistosoma mansoni hypothetical protein 0.1192 0.4562 0.7446
Onchocerca volvulus 0.0286 0.1044 0.2259
Trypanosoma brucei ring finger containing protein 0.0022 0.0017 0.0056
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.015 0.0311
Brugia malayi Cytochrome P450 family protein 0.0038 0.008 0.0175
Giardia lamblia Hypothetical protein 0.0022 0.0017 1
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0424 0.158 1
Giardia lamblia E3 ubiquitin ligase for Rad6p required for the ubiquitination of histone H2B 0.0022 0.0017 1
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0022 0.0017 0.0038
Trypanosoma brucei Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Plasmodium vivax vivapain-2 0.0037 0.0079 0.0155
Giardia lamblia Hypothetical protein 0.0022 0.0017 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0031 0.0065
Brugia malayi latrophilin 2 splice variant baaae 0.0038 0.008 0.0175
Trypanosoma cruzi cytochrome P450, putative 0.0038 0.008 0.0456
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0035
Brugia malayi hypothetical protein 0.0022 0.0017 0.0038
Trypanosoma cruzi hypothetical protein, conserved 0.0424 0.158 1
Echinococcus multilocularis microtubule associated protein 2 0.1595 0.6127 0.6127
Loa Loa (eye worm) brahma associated protein 0.1192 0.4562 1
Onchocerca volvulus 0.0424 0.158 0.3438
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Loa Loa (eye worm) cytochrome P450 family protein 0.0038 0.008 0.0173
Onchocerca volvulus 0.0099 0.0318 0.0663
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0092 0.0091
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0079 0.0173
Mycobacterium ulcerans aldehyde dehydrogenase 0.0136 0.0461 1
Onchocerca volvulus 0.0037 0.0079 0.0136
Trypanosoma cruzi Ankyrin repeats (3 copies)/Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0143 0.0488 0.3051
Entamoeba histolytica zinc finger domain containing protein 0.0022 0.0017 0.1052
Echinococcus granulosus neuropeptide s receptor 0.0512 0.1922 0.1921
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Trypanosoma brucei SNF2 family N-terminal domain/Ring finger domain containing protein, putative 0.0022 0.0017 0.0056
Schistosoma mansoni hypothetical protein 0.0424 0.158 0.2579
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0047 0.0118 0.4398
Loa Loa (eye worm) hypothetical protein 0.0424 0.158 0.3461
Loa Loa (eye worm) transcription factor SMAD2 0.0217 0.0776 0.1698
Schistosoma mansoni hypothetical protein 0.0022 0.0018 0.0029
Trichomonas vaginalis sex-determining protein fem-1, putative 0.0022 0.0017 0.0038
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.0909 0.199
Leishmania major hypothetical protein, conserved 0.0022 0.0017 0.0109
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0092 1
Loa Loa (eye worm) fibroinase 0.0037 0.0079 0.017
Trichomonas vaginalis ankyrin repeat domain protein, putative 0.0022 0.0017 0.0038
Trypanosoma cruzi Zn-finger in Ran binding protein and others, putative 0.0424 0.158 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Leishmania major hypothetical protein, conserved 0.0056 0.015 0.095
Mycobacterium ulcerans Type I modular polyketide synthase 0.0057 0.0155 0.3332
Trypanosoma cruzi hypothetical protein 0.0022 0.0017 0.0056
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0022 0.0017 0.0038
Echinococcus multilocularis SWI:SNF matrix associated 0.1192 0.4562 0.4562
Trypanosoma brucei PAB1-binding protein , putative 0.0056 0.015 0.0902
Leishmania major hypothetical protein, conserved 0.0022 0.0017 0.0109
Schistosoma mansoni peter pan-related 0.0022 0.0017 0.0028
Trichomonas vaginalis ankyrin, putative 0.0022 0.0017 0.0038
Leishmania major cathepsin L-like protease 0.0143 0.0488 0.3087
Plasmodium vivax RING zinc finger protein, putative 0.0022 0.0017 0.0019
Echinococcus multilocularis zinc finger protein Ran binding 0.0424 0.158 0.1579
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0046 0.0111 0.2392
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0079 0.0173
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0073 0.0072
Loa Loa (eye worm) hypothetical protein 0.0096 0.0305 0.0666
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Entamoeba histolytica zinc finger domain containing protein 0.0022 0.0017 0.1052
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Onchocerca volvulus 0.0037 0.0079 0.0136
Schistosoma mansoni serine/threonine protein kinase 0.0022 0.0017 0.0028
Leishmania major hypothetical protein, conserved 0.0424 0.158 1
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.002 0.0009 0.0204
Mycobacterium ulcerans thioesterase 0.0047 0.0118 0.253
Loa Loa (eye worm) hypothetical protein 0.0055 0.0148 0.0321
Leishmania major hypothetical protein, conserved 0.0022 0.0017 0.0109
Echinococcus multilocularis RING finger and transmembrane domain containing protein 0.0022 0.0017 0.0016
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0.0076 0.1639
Leishmania major hypothetical protein, conserved 0.0022 0.0017 0.0109
Echinococcus multilocularis cathepsin L cysteine protease 0.0037 0.0079 0.0078
Giardia lamblia Hypothetical protein 0.0022 0.0017 1
Echinococcus granulosus E3 ubiquitin protein ligase RNF146 0.0022 0.0017 0.0016
Onchocerca volvulus 0.0036 0.0073 0.0124
Loa Loa (eye worm) MH2 domain-containing protein 0.0217 0.0776 0.1698
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0046 0.0111 0.2392
Brugia malayi Zinc finger protein 183 homolog 0.0022 0.0018 0.0039
Trypanosoma cruzi PAB1-binding protein , putative 0.0056 0.015 0.0902
Echinococcus granulosus microtubule associated protein 2 0.1595 0.6127 0.6127
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0079 0.0173
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0047 0.0114 0.2478
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0055 0.0148 0.3205
Toxoplasma gondii cathepsin CPL 0.0037 0.0079 0.0136
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0057 0.0155 0.581
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Trypanosoma brucei Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0079 0.0173
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0025 0.0031 0.0029
Leishmania major hypothetical protein, unknown function 0.0022 0.0017 0.0109
Giardia lamblia Protein 21.1 0.0022 0.0017 1
Loa Loa (eye worm) fatty acid synthase 0.0056 0.0152 0.033
Loa Loa (eye worm) hypothetical protein 0.0424 0.158 0.3461
Echinococcus multilocularis SWI:SNF matrix associated 0.1192 0.4562 0.4562
Plasmodium falciparum E3 ubiquitin-protein ligase RNF5, putative 0.0022 0.0017 0.0019
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0057 0.0155 0.3352
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Mycobacterium tuberculosis Probable thioesterase TesA 0.0047 0.0118 0.2552
Leishmania major hypothetical protein, conserved 0.0022 0.0017 0.0109
Brugia malayi Zn-finger in Ran binding protein and others containing protein 0.0424 0.158 0.3463
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Brugia malayi YY1-associated factor 2 0.0424 0.158 0.3463
Echinococcus granulosus cathepsin l cysteine peptidase 0.0037 0.0079 0.0078
Trichomonas vaginalis ion channel nompc, putative 0.0022 0.0017 0.0038
Brugia malayi Cytochrome P450 family protein 0.0038 0.008 0.0175
Mycobacterium ulcerans polyketide synthase Pks13 0.0085 0.0264 0.5711
Mycobacterium leprae Polyketide synthase Pks13 0.0085 0.0264 1
Giardia lamblia Kinase, NEK 0.0022 0.0017 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0079 0.0173
Echinococcus multilocularis ring and YY1 binding protein 0.0424 0.158 0.1579
Plasmodium falciparum ataxin-2 like protein, putative 0.0056 0.015 0.0311
Loa Loa (eye worm) hypothetical protein 0.0027 0.0038 0.008
Brugia malayi MH2 domain containing protein 0.0217 0.0776 0.17
Echinococcus multilocularis E3 ubiquitin protein ligase MYLIP 0.0022 0.0017 0.0016
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0041 0.0092 0.0202
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0073 0.0072
Leishmania major cysteine peptidase A (CPA) 0.0037 0.0079 0.0499
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0035
Brugia malayi hypothetical protein 0.0022 0.0017 0.0038
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Trichomonas vaginalis ubiquitin-protein ligase BRE1, putative 0.0022 0.0017 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Echinococcus multilocularis cathepsin L cysteine protease 0.0037 0.0079 0.0078
Brugia malayi hypothetical protein 0.0022 0.0017 0.0038
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0085 0.0264 0.5724
Loa Loa (eye worm) hypothetical protein 0.0022 0.0017 0.0035
Entamoeba histolytica zinc finger domain containing protein 0.0022 0.0017 0.1052
Leishmania major cytochrome p450-like protein 0.0038 0.008 0.0506
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0057 0.0155 0.3352
Entamoeba histolytica zinc finger domain containing protein 0.0022 0.0017 0.1052
Trypanosoma brucei hypothetical protein, conserved 0.0424 0.158 1
Brugia malayi Neuralized family protein 0.0022 0.0017 0.0038
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0108 0.0353 0.0773
Brugia malayi Papain family cysteine protease containing protein 0.0037 0.0079 0.0173
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0045 0.0109 0.0108
Plasmodium vivax hypothetical protein, conserved 0.1192 0.4562 1
Giardia lamblia Protein 21.1 0.0022 0.0017 1
Trypanosoma cruzi UEV domain/Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Plasmodium falciparum trophozoite exported protein 1 0.0022 0.0017 0.0019
Mycobacterium ulcerans polyketide synthase Pks9 0.0038 0.008 0.1702
Entamoeba histolytica hypothetical protein 0.0022 0.0017 0.1052
Onchocerca volvulus 0.0424 0.158 0.3438
Giardia lamblia Ser/Thr protein kinase 0.0022 0.0017 1
Trichomonas vaginalis conserved hypothetical protein 0.0022 0.0017 0.0038
Brugia malayi hypothetical protein 0.0056 0.015 0.0329
Toxoplasma gondii type I fatty acid synthase, putative 0.0041 0.0091 0.0162
Loa Loa (eye worm) hypothetical protein 0.0424 0.158 0.3461
Echinococcus multilocularis 0.0022 0.0017 0.0016
Echinococcus multilocularis ring finger protein 113a 0.0022 0.0018 0.0017
Mycobacterium ulcerans Type I modular polyketide synthase 0.0057 0.0155 0.3332
Trypanosoma cruzi WLM domain containing protein, putative 0.0424 0.158 1
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0057 0.0155 0.581
Echinococcus multilocularis muscleblind protein 1 0.0334 0.1232 0.1231
Trypanosoma cruzi mitochondrial RNA binding complex 1 subunit, putative 0.0424 0.158 1
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0037 0.0079 0.0078
Trypanosoma cruzi hypothetical protein, conserved 0.0022 0.0017 0.0056
Loa Loa (eye worm) CYP4Cod1 0.0038 0.008 0.0173
Loa Loa (eye worm) ctsf protein 0.0037 0.0079 0.017
Trypanosoma cruzi Plus-3 domain/Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Trypanosoma cruzi Zinc finger, C3HC4 type (RING finger), putative 0.0022 0.0017 0.0056
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0037 0.0079 0.0173
Schistosoma mansoni cathepsin F (C01 family) 0.0037 0.0079 0.0129
Giardia lamblia Protein 21.1 0.0022 0.0017 1
Entamoeba histolytica hypothetical protein 0.0032 0.0059 0.6068
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0018 0.0001 0.003
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0037 0.0079 0.0173
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0057 0.0155 0.3332
Trichomonas vaginalis conserved hypothetical protein 0.1192 0.4562 1
Echinococcus multilocularis E3 ubiquitin protein ligase mib1 0.0022 0.0017 0.0016
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0029 0.0045 0.0062
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0037 0.0077 0.0131
Giardia lamblia Protein 21.1 0.0022 0.0017 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0019 0.0008 0.0014
Brugia malayi Inositol-1 0.0041 0.0092 0.0202
Onchocerca volvulus Cathepsin L homolog 0.0037 0.0079 0.0136

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.1623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 8.9125 uM PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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