Detailed information for compound 1556026

Basic information

Technical information
  • TDR Targets ID: 1556026
  • Name: 4-methyl-N-(1,4,7-trimethyl-2,3-dioxoquinoxal in-6-yl)benzamide
  • MW: 337.372 | Formula: C19H19N3O3
  • H donors: 1 H acceptors: 3 LogP: 2.37 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccc(cc1)C)Nc1cc2n(C)c(=O)c(=O)n(c2cc1C)C
  • InChi: 1S/C19H19N3O3/c1-11-5-7-13(8-6-11)17(23)20-14-10-16-15(9-12(14)2)21(3)18(24)19(25)22(16)4/h5-10H,1-4H3,(H,20,23)
  • InChiKey: PXUPMXXDJLDKPM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-methyl-N-(1,4,7-trimethyl-2,3-dioxo-quinoxalin-6-yl)benzamide
  • 4-methyl-N-(1,4,7-trimethyl-2,3-dioxo-6-quinoxalinyl)benzamide
  • N-(2,3-diketo-1,4,7-trimethyl-quinoxalin-6-yl)-4-methyl-benzamide
  • G221-0907
  • NCGC00141438-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0035 0.0134 0.0255
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0134 0.0573
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0145 0.1133 0.4884
Schistosoma mansoni hypothetical protein 0.0035 0.0134 0.0207
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0134 0.0027
Brugia malayi jmjC domain containing protein 0.0095 0.0677 0.2771
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0183 0.0258
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0186 0.0288
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0031 0.0098 0.0409
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0092 0.0649 0.0548
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0092 0.0653 0.5
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0134 0.0055
Plasmodium falciparum glutathione reductase 0.004 0.0182 0.0103
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0202 0.0313
Loa Loa (eye worm) beta-lactamase 0.0035 0.0134 0.0573
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.01 0.0728 0.1214
Loa Loa (eye worm) hypothetical protein 0.0075 0.0502 0.2222
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.01 0.0728 0.8186
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0031 0.0098 0.0138
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0134 0.0027
Loa Loa (eye worm) hypothetical protein 0.0048 0.0254 0.1109
Schistosoma mansoni hypothetical protein 0.0022 0.0018 0.0028
Plasmodium vivax glutathione reductase, putative 0.004 0.0182 0.0103
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0098 0.0083
Toxoplasma gondii exonuclease III APE 0.0037 0.0152 0.0915
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0038 0.0143
Schistosoma mansoni glutaminase 0.0267 0.2236 0.3455
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0152 0.0215
Brugia malayi nuclear receptor NHR-88 0.0031 0.0098 0.0083
Brugia malayi beta-lactamase 0.0035 0.0134 0.0253
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.0488 0.0688
Echinococcus multilocularis cpg binding protein 0.0066 0.0412 0.0581
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1133 0.175
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0102 0.0742 0.0642
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0031 0.0094 0.0142
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0152 0.0147
Toxoplasma gondii histone lysine methyltransferase SET1 0.0116 0.0871 1
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0018 0.0026
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0038 0.0059
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0098 0.0138
Entamoeba histolytica hypothetical protein 0.0111 0.0827 0.1384
Treponema pallidum fructose-bisphosphate aldolase 0.0574 0.5024 0.4947
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0134 0.0848
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0152 0.0037
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.003 0.009 0.0139
Brugia malayi Bromodomain containing protein 0.0092 0.0652 0.2653
Trichomonas vaginalis glutaminase, putative 0.0267 0.2236 0.4298
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0574 0.5024 1
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0031 0.0098 0.0409
Brugia malayi glucose-6-phosphate dehydrogenase 0.0092 0.0653 0.266
Schistosoma mansoni cpg binding protein 0.0066 0.0412 0.0636
Brugia malayi hypothetical protein 0.0264 0.2217 0.9911
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0031 0.0098 0.0083
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0111 0.0827 0.1166
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0098 0.0151
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0134 0.0252
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0152 0.5
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0152 0.0073
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0031 0.0098 0.0138
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0031 0.0098 0.0409
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0134 0.0208
Echinococcus granulosus cpg binding protein 0.0066 0.0412 0.0636
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0152 0.1164
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0098 0.0151
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0186 0.0288
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.0488 0.0754
Echinococcus granulosus survival motor neuron protein 1 0.0251 0.2098 0.3241
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0282 0.094
Brugia malayi Thioredoxin reductase 0.004 0.0182 0.0474
Onchocerca volvulus Bile acid receptor homolog 0.0031 0.0098 0.0084
Brugia malayi Steroid receptor seven-up type 2 0.0031 0.0098 0.0083
Toxoplasma gondii LsmAD domain-containing protein 0.0049 0.0265 0.2344
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0574 0.5024 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0134 0.0573
Schistosoma mansoni cpg binding protein 0.006 0.036 0.0557
Schistosoma mansoni hypothetical protein 0.018 0.1451 0.2243
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0152 0.0045
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0152 0.0654
Loa Loa (eye worm) steroid hormone receptor 0.0031 0.0098 0.0409
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0265 0.0187
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0574 0.5024 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0134 0.0573
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0098 0.0151
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0012 0.0018
Schistosoma mansoni cpg binding protein 0.0066 0.0412 0.0636
Loa Loa (eye worm) hypothetical protein 0.0035 0.0134 0.0573
Loa Loa (eye worm) hypothetical protein 0.0035 0.0134 0.0573
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0134 0.0027
Mycobacterium tuberculosis Probable dehydrogenase 0.0092 0.0649 0.0548
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0031 0.0098 0.0151
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0012 0.0018
Loa Loa (eye worm) glutaminase 0.0267 0.2236 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0134 0.0573
Leishmania major trypanothione reductase 0.004 0.0182 0.0919
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0182 0.0076
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1133 0.175
Mycobacterium tuberculosis Conserved protein 0.0035 0.0134 0.0027
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0574 0.5024 1
Giardia lamblia Fructose-bisphosphate aldolase 0.0574 0.5024 1
Brugia malayi Bromodomain containing protein 0.0032 0.0105 0.0118
Loa Loa (eye worm) hypothetical protein 0.0035 0.0134 0.0573
Leishmania major hypothetical protein, conserved 0.0049 0.0265 0.2523
Schistosoma mansoni zinc finger protein 0.0027 0.0058 0.009
Plasmodium falciparum ataxin-2 like protein, putative 0.0049 0.0265 0.0187
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0145 0.1133 0.5052
Loa Loa (eye worm) hypothetical protein 0.0021 0.0012 0.0024
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0574 0.5024 1
Echinococcus granulosus ecdysone induced protein 78C 0.0031 0.0098 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0031 0.0098 0.0083
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0092 0.0653 0.0509
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0092 0.0649 0.0548
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0152 0.0037
Entamoeba histolytica hypothetical protein 0.0111 0.0827 0.1384
Entamoeba histolytica hypothetical protein 0.0111 0.0827 0.1384
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0092 0.0649 0.0522
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0134 0.0189
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0031 0.0098 0.0083
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0031 0.0098 0.0151
Onchocerca volvulus 0.0035 0.0134 0.0255
Schistosoma mansoni RAR-like nuclear receptor 0.0031 0.0098 0.0151
Onchocerca volvulus 0.006 0.036 0.1313
Plasmodium falciparum thioredoxin reductase 0.004 0.0182 0.0103
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.006 0.0363 0.3582
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0134 0.0027
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0152 0.0345
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0031 0.0098 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0031 0.0098 0.0083
Loa Loa (eye worm) hypothetical protein 0.0054 0.0305 0.134
Schistosoma mansoni nuclear hormone receptor 0.0031 0.0098 0.0151
Trypanosoma brucei PAB1-binding protein , putative 0.0049 0.0265 0.2523
Echinococcus granulosus GPCR family 2 0.0035 0.0134 0.0207
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0134 0.0253
Trypanosoma brucei trypanothione reductase 0.004 0.0182 0.0919
Schistosoma mansoni survival motor neuron protein 0.0051 0.0282 0.0436
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0409
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0102 0.0742 0.0642
Echinococcus multilocularis peregrin 0.0032 0.0105 0.0148
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.01 0.0728 0.1311
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0134 0.0848
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0031 0.0098 0.0409
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.01 0.0728 0.1214
Echinococcus granulosus geminin 0.018 0.1451 0.2243
Schistosoma mansoni coup transcription factor 0.0031 0.0098 0.0151
Loa Loa (eye worm) hypothetical protein 0.0029 0.008 0.0329
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0092 0.0653 0.101
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.006 0.0363 0.0232
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0134 0.0207
Brugia malayi CXXC zinc finger family protein 0.006 0.036 0.1301
Echinococcus multilocularis fetal alzheimer antigen, falz 0.003 0.009 0.0127
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.028 0.2361 0.2256
Brugia malayi Nuclear hormone receptor-like 1 0.0031 0.0098 0.0083
Schistosoma mansoni hypothetical protein 0.0035 0.0134 0.0207
Plasmodium falciparum nicotinamide/nicotinic acid mononucleotide adenylyltransferase 0.1122 1 1
Toxoplasma gondii thioredoxin reductase 0.004 0.0182 0.1292
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0098 0.0083
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.1133 0.175
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.028 0.2361 0.2278
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.0819 0.3428
Schistosoma mansoni steroid hormone receptor ad4bp 0.0031 0.0098 0.0151
Mycobacterium tuberculosis Conserved protein 0.0035 0.0134 0.0027
Schistosoma mansoni hypothetical protein 0.0035 0.0134 0.0207
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0089 0.0044
Loa Loa (eye worm) hypothetical protein 0.011 0.0819 0.3644
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0409
Schistosoma mansoni retinoic acid receptor RXR 0.0031 0.0098 0.0151
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0152 0.0235
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0182 0.1689
Loa Loa (eye worm) hypothetical protein 0.0049 0.0265 0.1161
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0265 0.3158
Onchocerca volvulus Protein ultraspiracle homolog 0.0031 0.0098 0.0084
Schistosoma mansoni hypothetical protein 0.0029 0.008 0.0123
Mycobacterium tuberculosis Probable oxidoreductase 0.0102 0.0742 0.0642
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0127 0.0969 0.1497
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0502 0.1958
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0031 0.0098 0.0083
Loa Loa (eye worm) hypothetical protein 0.0045 0.0228 0.0995
Onchocerca volvulus Huntingtin homolog 0.0264 0.2217 1
Brugia malayi photoreceptor-specific nuclear receptor 0.0031 0.0098 0.0083
Echinococcus multilocularis GPCR, family 2 0.0035 0.0134 0.0189
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0145 0.1133 0.175
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0152 0.1164
Schistosoma mansoni hypothetical protein 0.0035 0.0134 0.0207
Schistosoma mansoni microtubule-associated protein tau 0.0733 0.6472 1
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0134 0.0027
Loa Loa (eye worm) hypothetical protein 0.0035 0.0134 0.0573
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0574 0.5024 1
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0182 0.0787
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0092 0.0653 0.101
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0031 0.0098 0.0409
Schistosoma mansoni hypothetical protein 0.0075 0.0502 0.0776
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0677 0.0955
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0031 0.0098 0.0083
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0223 0.1843 0.1755
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0031 0.0098 0.0083
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0202 0.0285
Toxoplasma gondii ABC1 family protein 0.0035 0.0134 0.0689
Brugia malayi ecdysteroid receptor 0.0031 0.0098 0.0083
Brugia malayi hypothetical protein 0.0049 0.0265 0.0861
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0102 0.0742 0.0616
Echinococcus multilocularis survival motor neuron protein 1 0.0251 0.2098 0.296
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0092 0.0653 0.0922
Brugia malayi beta-lactamase family protein 0.0035 0.0134 0.0253
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0574 0.5024 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0049 0.0265 0.3158
Echinococcus granulosus FTZ F1 alpha 0.0031 0.0098 0.0151
Echinococcus granulosus zinc finger protein 0.0027 0.0058 0.009
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0186 0.0288
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0012 0.0018
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0092 0.0653 0.0526
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0092 0.0653 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0031 0.0098 0.0138
Echinococcus granulosus fetal alzheimer antigen falz 0.003 0.009 0.0139
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0677 0.1046
Loa Loa (eye worm) hypothetical protein 0.005 0.0267 0.117
Mycobacterium tuberculosis Conserved protein 0.0035 0.0134 0.0027
Echinococcus granulosus thioredoxin glutathione reductase 0.0041 0.0187 0.0289
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.01 0.0728 0.0653
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0031 0.0098 0.0409
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.008 0.0123
Schistosoma mansoni ap endonuclease 0.0037 0.0152 0.0235
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0031 0.0098 0.0151
Brugia malayi nuclear hormone receptor 0.0031 0.0098 0.0083
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0134 0.019
Brugia malayi jmjC domain containing protein 0.0041 0.0186 0.0495
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.01 0.0728 0.0653
Loa Loa (eye worm) glutaminase 2 0.0267 0.2236 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0134 0.0027
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0092 0.0649 0.0548
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.1133 0.1598
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0186 0.0807
Echinococcus granulosus jumonji domain containing protein 0.004 0.0183 0.0282
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0359 0.1583
Schistosoma mansoni jumonji domain containing protein 0.0075 0.05 0.0773
Brugia malayi steroid hormone receptor 0.0031 0.0098 0.0083
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0134 0.0189
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0092 0.0649 0.0548
Echinococcus granulosus peregrin 0.0032 0.0105 0.0163
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0092 0.0653 1
Onchocerca volvulus 0.0035 0.0134 0.0255
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0409
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.008 0.0329
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0031 0.0098 0.0151
Onchocerca volvulus 0.0051 0.0282 0.0948
Loa Loa (eye worm) CXXC zinc finger family protein 0.006 0.036 0.1587
Schistosoma mansoni ap endonuclease 0.0037 0.0152 0.0235
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0409
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0031 0.0098 0.0151
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0031 0.0098 0.0151
Brugia malayi hypothetical protein 0.0032 0.0107 0.0124
Loa Loa (eye worm) hypothetical protein 0.0035 0.0134 0.0573
Echinococcus multilocularis thyroid hormone receptor alpha 0.0031 0.0098 0.0138
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0134 0.0252
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0409
Schistosoma mansoni hypothetical protein 0.0024 0.0038 0.0059
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.008 0.0123
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0098 0.0083
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0152 0.0073
Mycobacterium ulcerans glutaminase 0.0267 0.2236 0.213
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0031 0.0098 0.0151
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.01 0.0728 0.1214
Echinococcus multilocularis ecdysone induced protein 78C 0.0031 0.0098 0.0138
Mycobacterium tuberculosis Probable reductase 0.0092 0.0649 0.0548
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0182 0.0103
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0012 0.0017
Echinococcus multilocularis geminin 0.018 0.1451 0.2048
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.028 0.2361 0.2256
Onchocerca volvulus Huntingtin homolog 0.0264 0.2217 1
Mycobacterium ulcerans bifunctional nicotinate-nucleotide adenylyltransferase NadD/hypothetical protein 0.1122 1 1
Loa Loa (eye worm) hypothetical protein 0.0264 0.2217 0.9914
Brugia malayi glutathione reductase 0.004 0.0182 0.0474
Brugia malayi PHD-finger family protein 0.0033 0.0115 0.0164
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0092 0.0653 1
Loa Loa (eye worm) hypothetical protein 0.0251 0.2098 0.938
Mycobacterium tuberculosis Probable nicotinate-nucleotide adenylyltransferase NadD (deamido-NAD(+) pyrophosphorylase) (deamido-NAD(+) diphosphorylase) (nic 0.1122 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0145 0.1133 0.175
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0574 0.5024 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0152 0.0018
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0098 0.0138
Echinococcus granulosus microtubule associated protein 2 0.0733 0.6472 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0575 0.255
Onchocerca volvulus 0.0031 0.0098 0.0084
Plasmodium vivax ataxin-2 like protein, putative 0.0049 0.0265 0.0187
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0031 0.0098 0.0151
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0409
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0031 0.0098 0.0151
Echinococcus multilocularis zinc finger protein 0.0027 0.0058 0.0082
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0134 0.0027
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0409
Treponema pallidum hypothetical protein 0.1122 1 1
Schistosoma mansoni hypothetical protein 0.0111 0.0827 0.1277
Plasmodium vivax nicotinate-nucleotide adenylyltransferase, putative 0.1122 1 1
Echinococcus multilocularis microtubule associated protein 2 0.0733 0.6472 0.9131
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0031 0.0098 0.0138
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0031 0.0098 0.0409
Loa Loa (eye worm) hypothetical protein 0.0264 0.2217 0.9914
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0031 0.0098 0.0151
Schistosoma mansoni bromodomain containing protein 0.0078 0.0526 0.0813
Echinococcus multilocularis FTZ F1 alpha 0.0031 0.0098 0.0138
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0134 0.0208
Brugia malayi beta-lactamase family protein 0.0035 0.0134 0.0253
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0092 0.0653 0.2901
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.008 0.0113
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0152 0.0345
Brugia malayi glutaminase DH11.1 0.0267 0.2236 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0135 0.0191
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0574 0.5024 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0134 0.0207
Schistosoma mansoni hypothetical protein 0.018 0.1451 0.2243
Echinococcus multilocularis thioredoxin glutathione reductase 0.0041 0.0187 0.0264
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.0819 0.3428
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0031 0.0098 0.0083
Brugia malayi hypothetical protein 0.0251 0.2098 0.9359
Schistosoma mansoni thyroid hormone receptor 0.0031 0.0098 0.0151
Schistosoma mansoni transcription factor LCR-F1 0.0111 0.0827 0.1277
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0134 0.0208
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0574 0.5024 1
Loa Loa (eye worm) glutathione reductase 0.004 0.0182 0.0787
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0145 0.1133 0.1598
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0152 0.0336
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0409
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.0819 0.3644
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0111 0.0827 0.1277
Brugia malayi hypothetical protein 0.0111 0.0827 0.3464
Entamoeba histolytica hypothetical protein 0.0111 0.0827 0.1384
Schistosoma mansoni hypothetical protein 0.0051 0.0282 0.0436
Brugia malayi Bromodomain containing protein 0.0045 0.0228 0.0686
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0031 0.0098 0.0083
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0801 0.7088 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0031 0.0098 0.0084
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0031 0.0098 0.0083
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0018 0.0028

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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