TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 428.854 | Formula: C16H20ClF3N2O4S
H donors: 1 H acceptors: 3 LogP: 2.99 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: C[C@H]1C[C@H](O1)CN(S(=O)(=O)c1ccc(cc1)Cl)[C@@H](C(=O)N)CCC(F)(F)F
InChi: 1S/C16H20ClF3N2O4S/c1-10-8-12(26-10)9-22(14(15(21)23)6-7-16(18,19)20)27(24,25)13-4-2-11(17)3-5-13/h2-5,10,12,14H,6-9H2,1H3,(H2,21,23)/t10-,12-,14+/m0/s1
InChiKey: YAYPZOSESAPDFR-VHRBIJSZSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	APH1B gamma secretase subunit	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Echinococcus granulosus	gamma secretase subunit aph 1	Get druggable targets OG5_130831	All targets in OG5_130831
Schistosoma japonicum	ko:K06172 anterior pharynx defective 1, putative	Get druggable targets OG5_130831	All targets in OG5_130831
Brugia malayi	gamma-secretase subunit aph-1	Get druggable targets OG5_130831	All targets in OG5_130831
Schistosoma mansoni	gamma-secretase subunit aph-1	Get druggable targets OG5_130831	All targets in OG5_130831
Loa Loa (eye worm)	gamma-secretase subunit aph-1	Get druggable targets OG5_130831	All targets in OG5_130831
Echinococcus multilocularis	gamma secretase subunit aph 1	Get druggable targets OG5_130831	All targets in OG5_130831

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus granulosus	choline O acetyltransferase	0.0371	0.1145	0.2133
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.0165	0.2001
Loa Loa (eye worm)	hypothetical protein	0.0093	0.0248	0.0241
Mycobacterium leprae	DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE)	0.0077	0.0194	0.5
Schistosoma mansoni	hypothetical protein	0.0064	0.0153	0.0803
Echinococcus multilocularis	muscleblind protein	0.0157	0.0453	0.0839
Trypanosoma cruzi	hypothetical protein, conserved	0.0371	0.1145	0.2139
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0079	0.0813
Trichomonas vaginalis	chromobox protein, putative	0.0068	0.0165	0.2001
Echinococcus granulosus	geminin	0.0333	0.1024	0.1907
Trichomonas vaginalis	Nicastrin precursor, putative	0.0121	0.0338	0.4366
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0033	0.0025
Loa Loa (eye worm)	latrophilin receptor protein 2	0.003	0.0043	0.0035
Brugia malayi	hypothetical protein	0.0087	0.0228	0.0226
Mycobacterium ulcerans	dihydrofolate reductase DfrA	0.0077	0.0194	0.5
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0054	0.0121	0.0218
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0098	0.0265	0.1404
Leishmania major	dihydrofolate reductase-thymidylate synthase	0.0077	0.0194	0.0363
Leishmania major	carnitine palmitoyltransferase-like protein	0.0626	0.1968	0.3677
Echinococcus multilocularis	GPCR, family 2	0.003	0.0043	0.0072
Echinococcus multilocularis	carnitine O palmitoyltransferase 2	0.0626	0.1968	0.3672
Plasmodium falciparum	bifunctional dihydrofolate reductase-thymidylate synthase	0.0077	0.0194	1
Brugia malayi	Latrophilin receptor protein 2	0.003	0.0043	0.004
Leishmania major	carnitine/choline acetyltransferase, putative	0.0371	0.1145	0.2139
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0099	0.0266	0.0264
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.007	0.0686
Trichomonas vaginalis	Nicastrin precursor, putative	0.0121	0.0338	0.4366
Brugia malayi	hypothetical protein	0.0087	0.0228	0.0226
Onchocerca volvulus		0.0099	0.0266	0.2023
Loa Loa (eye worm)	choline/Carnitine O-acyltransferase	0.0626	0.1968	0.1962
Loa Loa (eye worm)	hypothetical protein	0.0121	0.0338	0.0331
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0033	0.0061
Brugia malayi	MH2 domain containing protein	0.0125	0.0351	0.0349
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.003	0.0043	0.0072
Trichomonas vaginalis	Clan AD, family A22, presenilin-like aspartic peptidase	0.0248	0.0749	1
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.002	0.0013	0.0047
Loa Loa (eye worm)	carnitine O-palmitoyltransferase I isoform	0.0371	0.1145	0.1138
Brugia malayi	Presenilin spe-4	0.0087	0.0228	0.0226
Schistosoma mansoni	dihydrofolate reductase	0.0077	0.0194	0.1026
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0098	0.0265	0.0487
Trypanosoma cruzi	choline/carnitine O-acetyltransferase, putative	0.0371	0.1145	0.2139
Schistosoma mansoni	survival motor neuron protein	0.0099	0.0266	0.1412
Echinococcus multilocularis	gamma secretase subunit aph 1	0.0592	0.1858	0.3467
Trypanosoma cruzi	Aph-1 protein, putative	0.0231	0.0692	0.1293
Schistosoma mansoni	subfamily A22A unassigned peptidase (A22 family)	0.0248	0.0749	0.4016
Echinococcus multilocularis	chromobox protein 1	0.0068	0.0165	0.0301
Echinococcus granulosus	GPCR family 2	0.003	0.0043	0.0072
Schistosoma mansoni	hypothetical protein	0.003	0.0043	0.0207
Schistosoma mansoni	ataxia telangiectasia mutated (atm)	0.0022	0.002	0.0083
Echinococcus granulosus	fetal alzheimer antigen falz	0.002	0.0013	0.0016
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.003	0.0043	0.0072
Echinococcus multilocularis	chromobox protein 1	0.0068	0.0165	0.0301
Brugia malayi	Presenilin spe-4	0.0087	0.0228	0.0226
Schistosoma mansoni	hypothetical protein	0.003	0.0043	0.0207
Brugia malayi	dihydrofolate reductase family protein	0.0077	0.0194	0.0192
Toxoplasma gondii	hypothetical protein	0.007	0.0174	0.7392
Echinococcus multilocularis	presenilin enhancer 2	0.0233	0.0699	0.13
Schistosoma mansoni	chromobox protein	0.0068	0.0165	0.087
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.003	0.0043	0.004
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0093	0.0248	0.0246
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0453	0.0446
Echinococcus multilocularis	Nicastrin	0.0121	0.0338	0.0624
Trypanosoma brucei	carnitine O-palmitoyltransferase, putative	0.0371	0.1145	0.5777
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0032	0.0052	0.0089
Trypanosoma cruzi	Nicastrin, putative	0.0044	0.0091	0.017
Leishmania major	hypothetical protein, conserved	0.007	0.0174	0.0324
Schistosoma mansoni	gamma-secretase subunit aph-1	0.0592	0.1858	1
Brugia malayi	hypothetical protein	0.0087	0.0228	0.0226
Trypanosoma brucei	hypothetical protein, conserved	0.0371	0.1145	0.5777
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0066	0.0059
Brugia malayi	Choline O-acetyltransferase	0.0371	0.1145	0.1143
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0022	0.002	0.0037
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0093	0.0248	0.0246
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0034	0.0196
Echinococcus granulosus	chromobox protein 1	0.0068	0.0165	0.0301
Schistosoma mansoni	hypothetical protein	0.0333	0.1024	0.5502
Trypanosoma cruzi	Aph-1 protein, putative	0.0231	0.0692	0.1293
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0059	0.0052
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0093	0.0248	0.0241
Schistosoma mansoni	chromobox protein	0.0068	0.0165	0.087
Loa Loa (eye worm)	transcription factor SMAD2	0.0125	0.0351	0.0344
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0153	0.0146
Trypanosoma brucei	carnitine O-palmitoyltransferase II, putative	0.0371	0.1145	0.5777
Brugia malayi	Phosphatidylinositol 3- and 4-kinase family protein	0.0022	0.002	0.0017
Trypanosoma cruzi	PAB1-binding protein , putative	0.0026	0.0033	0.0061
Trypanosoma brucei	carnitine O-acetyltransferase, putative	0.0371	0.1145	0.5777
Schistosoma mansoni	hypothetical protein	0.0333	0.1024	0.5502
Brugia malayi	gamma-secretase subunit pen-2	0.0233	0.0699	0.0697
Trypanosoma cruzi	carnitine O-palmitoyltransferase II, putative	0.0626	0.1968	0.3677
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0098	0.0265	0.0487
Schistosoma mansoni	hypothetical protein	0.0019	0.0007	0.0017
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0098	0.0265	0.0487
Brugia malayi	PHD-finger family protein	0.0022	0.002	0.0017
Echinococcus granulosus	gamma secretase subunit aph 1	0.0592	0.1858	0.3467
Echinococcus granulosus	chromobox protein 1	0.0068	0.0165	0.0301
Schistosoma mansoni	hypothetical protein	0.003	0.0043	0.0207
Echinococcus multilocularis	geminin	0.0333	0.1024	0.1907
Brugia malayi	latrophilin 2 splice variant baaae	0.0064	0.0153	0.0151
Schistosoma mansoni	hypothetical protein	0.0121	0.0338	0.18
Trichomonas vaginalis	chromobox protein, putative	0.0041	0.0079	0.0813
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0098	0.0265	0.1404
Echinococcus multilocularis	muscleblind protein 1	0.0157	0.0453	0.0839
Onchocerca volvulus		0.0371	0.1145	1
Trichomonas vaginalis	conserved hypothetical protein	0.0027	0.0034	0.0196
Trypanosoma brucei	Aph-1 protein, putative	0.0231	0.0692	0.3451
Brugia malayi	Bromodomain containing protein	0.0068	0.0166	0.0163
Loa Loa (eye worm)	hypothetical protein	0.3112	1	1
Echinococcus granulosus	nicalin	0.0044	0.0091	0.0162
Echinococcus granulosus	presenilin	0.0248	0.0749	0.1392
Trypanosoma cruzi	choline/carnitine O-acyltransferase, putative	0.0371	0.1145	0.2139
Brugia malayi	Heterochromatin protein 1	0.0068	0.0165	0.0163
Brugia malayi	hypothetical protein	0.0484	0.151	0.1508
Loa Loa (eye worm)	hypothetical protein	0.0484	0.151	0.1504
Echinococcus multilocularis	presenilin	0.0248	0.0749	0.1392
Onchocerca volvulus		0.0371	0.1145	1
Leishmania major	presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative	0.0248	0.0749	0.1399
Loa Loa (eye worm)	hypothetical protein	0.0064	0.0153	0.0146
Echinococcus granulosus	survival motor neuron protein 1	0.0484	0.151	0.2816
Loa Loa (eye worm)	hypothetical protein	0.0038	0.007	0.0062
Onchocerca volvulus		0.0371	0.1145	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0371	0.1145	0.2139
Echinococcus granulosus	presenilin enhancer 2	0.0233	0.0699	0.13
Trypanosoma cruzi	hypothetical protein, conserved	0.0371	0.1145	0.2139
Trypanosoma brucei	presenilin-like aspartic peptidase, putative	0.0248	0.0749	0.3742
Echinococcus multilocularis	dihydrofolate reductase	0.0077	0.0194	0.0356
Trichomonas vaginalis	Clan AD, family A22, presenilin-like aspartic peptidase	0.0248	0.0749	1
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0009	0.0002
Brugia malayi	Presenilin family protein	0.0248	0.0749	0.0746
Trypanosoma cruzi	presenilin-like aspartic peptidase, putative	0.0248	0.0749	0.1399
Echinococcus granulosus	carnitine O palmitoyltransferase 1 liver	0.1673	0.5352	1
Trypanosoma cruzi	dihydrofolate reductase-thymidylate synthase	0.0077	0.0194	0.0363
Mycobacterium tuberculosis	Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase)	0.0077	0.0194	0.5
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.003	0.0043	0.0072
Loa Loa (eye worm)	heterochromatin protein 1	0.0068	0.0165	0.0158
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0054	0.0121	0.0218
Loa Loa (eye worm)	dihydrofolate reductase	0.0077	0.0194	0.0187
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0098	0.0265	0.1404
Trypanosoma cruzi	hypothetical protein, conserved	0.0371	0.1145	0.2139
Entamoeba histolytica	hypothetical protein	0.0044	0.0091	0.0977
Chlamydia trachomatis	dihydrofolate reductase	0.0077	0.0194	0.5
Loa Loa (eye worm)	gamma-secretase subunit pen-2	0.0233	0.0699	0.0693
Echinococcus granulosus	muscleblind protein	0.0157	0.0453	0.0839
Brugia malayi	Dihydrofolate reductase	0.0077	0.0194	0.0192
Echinococcus multilocularis	serine protein kinase ATM	0.0022	0.002	0.0029
Trypanosoma cruzi	carnitine O-acetyltransferase, putative	0.0371	0.1145	0.2139
Loa Loa (eye worm)	hypothetical protein	0.003	0.0043	0.0036
Toxoplasma gondii	LsmAD domain-containing protein	0.0026	0.0033	0.0625
Loa Loa (eye worm)	hypothetical protein	0.0157	0.0453	0.0446
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0098	0.0265	0.0487
Loa Loa (eye worm)	presenilin spe-4	0.0087	0.0228	0.0221
Loa Loa (eye worm)	MH2 domain-containing protein	0.0125	0.0351	0.0344
Brugia malayi	Presenilin-like protein At2g29900	0.0087	0.0228	0.0226
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0032	0.0052	0.0089
Schistosoma mansoni	choline o-acyltransferase	0.0371	0.1145	0.6153
Echinococcus granulosus	Nicastrin	0.0121	0.0338	0.0624
Loa Loa (eye worm)	hypothetical protein	0.0371	0.1145	0.1138
Trichomonas vaginalis	conserved hypothetical protein	0.0038	0.007	0.0686
Entamoeba histolytica	presenilin 1 peptidase, putative	0.0248	0.0749	1
Trypanosoma brucei	Nicastrin, putative	0.0044	0.0091	0.0366
Brugia malayi	Choline/Carnitine o-acyltransferase family protein	0.0371	0.1145	0.1143
Trypanosoma cruzi	carnitine/choline acetyltransferase, putative	0.0371	0.1145	0.2139
Echinococcus multilocularis	Nicastrin	0.0121	0.0338	0.0624
Schistosoma mansoni	choline o-acyltransferase	0.0371	0.1145	0.6153
Trypanosoma cruzi	choline/carnitine O-acyltransferase, putative	0.1673	0.5352	1
Brugia malayi	hypothetical protein	0.0121	0.0338	0.0336
Echinococcus multilocularis	carnitine O palmitoyltransferase 1, liver	0.1673	0.5352	1
Echinococcus multilocularis	choline O acetyltransferase	0.0371	0.1145	0.2133
Loa Loa (eye worm)	choline O-acetyltransferase	0.0371	0.1145	0.1138
Trypanosoma cruzi	presenilin-like aspartic peptidase, putative	0.0248	0.0749	0.1399
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0098	0.0265	0.0262
Loa Loa (eye worm)	hypothetical protein	0.003	0.0043	0.0035
Brugia malayi	Choline/Carnitine o-acyltransferase family protein	0.0626	0.1968	0.1966
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0098	0.0265	0.0257
Echinococcus granulosus	dihydrofolate reductase	0.0077	0.0194	0.0356
Trypanosoma brucei	dihydrofolate reductase-thymidylate synthase	0.0077	0.0194	0.0898
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0071	0.0064
Loa Loa (eye worm)	gamma-secretase subunit aph-1	0.0592	0.1858	0.1852
Trichomonas vaginalis	Clan AD, family A22, presenilin-like aspartic peptidase	0.0248	0.0749	1
Trypanosoma cruzi	phosphatidylinositol kinase related protein, putative	0.0019	0.0009	0.0018
Leishmania major	choline/Carnitine o-acyltransferase-like protein	0.1673	0.5352	1
Brugia malayi	chromobox protein homolog 3	0.0038	0.007	0.0067
Trypanosoma cruzi	choline/carnitine O-acyltransferase, putative	0.1673	0.5352	1
Echinococcus granulosus	carnitine O palmitoyltransferase 2	0.0626	0.1968	0.3672
Schistosoma mansoni	bromodomain containing protein	0.0057	0.0131	0.0686
Brugia malayi	Presenilin spe-4	0.0087	0.0228	0.0226
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.002	0.0013	0.0016
Leishmania major	hypothetical protein, conserved	0.0026	0.0033	0.0061
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.003	0.0043	0.0072
Toxoplasma gondii	bifunctional dihydrofolate reductase-thymidylate synthase	0.0077	0.0194	0.8391
Toxoplasma gondii	hypothetical protein	0.0087	0.0228	1
Brugia malayi	Bromodomain containing protein	0.0035	0.0059	0.0056
Trypanosoma cruzi	hypothetical protein, conserved	0.0371	0.1145	0.2139
Schistosoma mansoni	hypothetical protein	0.003	0.0043	0.0207
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0041	0.0079	0.0324
Echinococcus multilocularis	nicalin	0.0044	0.0091	0.0162
Onchocerca volvulus		0.0371	0.1145	1
Brugia malayi	hypothetical protein	0.0026	0.0033	0.003
Trypanosoma brucei	PAB1-binding protein , putative	0.0026	0.0033	0.0067
Schistosoma mansoni	hypothetical protein	0.0099	0.0266	0.1412
Trypanosoma brucei	carnitine O-palmitoyltransferase II, putative	0.0626	0.1968	1
Brugia malayi	Choline O-acetyltransferase	0.0371	0.1145	0.1143
Echinococcus granulosus	serine protein kinase ATM	0.0022	0.002	0.0029
Trypanosoma brucei	Presenilin enhancer-2 subunit of gamma secretase, putative	0.007	0.0174	0.0791
Brugia malayi	gamma-secretase subunit aph-1	0.0592	0.1858	0.1856
Onchocerca volvulus	Heterochromatin protein 1 homolog	0.0038	0.007	0.024
Echinococcus multilocularis	survival motor neuron protein 1	0.0484	0.151	0.2816
Brugia malayi	hypothetical protein	0.0121	0.0338	0.0336
Trypanosoma cruzi	Nicastrin, putative	0.0044	0.0091	0.017
Plasmodium vivax	bifunctional dihydrofolate reductase-thymidylate synthase, putative	0.0077	0.0194	1
Brugia malayi	Muscleblind-like protein	0.0157	0.0453	0.0451
Trypanosoma cruzi	carnitine/choline acetyltransferase, putative	0.0371	0.1145	0.2139

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 10.8 nM	Inhibition of gamma-secretase-mediated cleavage of human amyloid beta protein expressed in human H4 cells assessed as reduction in amyloid beta42 production by ELISA technique	ChEMBL.	21995460

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1916334

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1581226