Detailed information for compound 1584279

Basic information

Technical information
  • TDR Targets ID: 1584279
  • Name: 1-(2,4-dichlorobenzoyl)-N-(pyridin-3-ylmethyl )piperidine-4-carboxamide
  • MW: 392.279 | Formula: C19H19Cl2N3O2
  • H donors: 1 H acceptors: 3 LogP: 2.83 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C1CCN(CC1)C(=O)c1ccc(cc1Cl)Cl)NCc1cccnc1
  • InChi: 1S/C19H19Cl2N3O2/c20-15-3-4-16(17(21)10-15)19(26)24-8-5-14(6-9-24)18(25)23-12-13-2-1-7-22-11-13/h1-4,7,10-11,14H,5-6,8-9,12H2,(H,23,25)
  • InChiKey: APTFLHUZQXNSJB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(2,4-dichlorobenzoyl)-N-(3-pyridylmethyl)piperidine-4-carboxamide
  • 1-[(2,4-dichlorophenyl)-oxomethyl]-N-(3-pyridylmethyl)-4-piperidinecarboxamide
  • 1-(2,4-dichlorobenzoyl)-N-(3-pyridylmethyl)isonipecotamide
  • 1-(2,4-dichlorophenyl)carbonyl-N-(pyridin-3-ylmethyl)piperidine-4-carboxamide
  • MLS000099316
  • SMR000071462
  • ZINC01156332
  • 1-(2,4-dichlorobenzoyl)-N-(3-pyridinylmethyl)-4-piperidinecarboxamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni adenosylhomocysteinase 0.0156 0.075 0.0943
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Echinococcus granulosus histone arginine methyltransferase CARMER 0.0152 0.0726 0.0934
Loa Loa (eye worm) hypothetical protein 0.0056 0.0141 0.0141
Echinococcus granulosus spermidine synthase 0.1141 0.6775 0.8862
Brugia malayi Melatonin receptor type 1A 0.0042 0.0056 0.0061
Toxoplasma gondii adenosylhomocysteinase, putative 0.0252 0.1337 0.1836
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Treponema pallidum purine nucleoside phosphorylase (deoD) 0.0193 0.0977 0.5
Leishmania major nucleoside phosphorylase-like protein 0.0193 0.0977 0.1363
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.01 0.0407 0.0516
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.068 0.3954 0.5797
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Brugia malayi Pre-SET motif family protein 0.0199 0.1012 0.1113
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0226 0.1176 0.1503
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0042 0.0056 0.003
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.0056 0.0047
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Leishmania major modification methylase-like protein 0.0625 0.3621 0.5301
Brugia malayi CXXC zinc finger family protein 0.0454 0.2574 0.2832
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0056 0.0141 0.0142
Loa Loa (eye worm) Carm1-pending protein 0.0152 0.0726 0.0785
Plasmodium vivax adenosylhomocysteinase(S-adenosyl-L-homocystein e hydrolase), putative 0.0252 0.1337 0.1716
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.0056 0.0056
Onchocerca volvulus 0.0121 0.0534 0.0481
Echinococcus multilocularis arginine glutamic acid dipeptide (RE) repeats 0.0056 0.0141 0.0167
Echinococcus granulosus hypothetical protein 0.0042 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Echinococcus granulosus dro:myosuppressin receptor 0.0042 0.0056 0.0056
Schistosoma mansoni hepatoma derived growth factor 0.0121 0.0534 0.0659
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0042 0.0056 0.0056
Trypanosoma cruzi spermidine synthase, putative 0.1141 0.6775 1
Echinococcus multilocularis protein arginine N methyltransferase 7 0.0166 0.0809 0.1043
Schistosoma mansoni uridine phosphorylase 0.0193 0.0977 0.124
Plasmodium falciparum adenosylhomocysteinase 0.0252 0.1337 0.1716
Schistosoma mansoni methylthioadenosine phosphorylase 0.1042 0.617 0.8064
Loa Loa (eye worm) hypothetical protein 0.0488 0.2778 0.3046
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.0056 0.003
Trypanosoma brucei methylthioadenosine phosphorylase, putative 0.1042 0.617 0.9099
Loa Loa (eye worm) hypothetical protein 0.0385 0.2151 0.2355
Brugia malayi hypothetical protein 0.0121 0.0534 0.0587
Echinococcus multilocularis S adenosylmethionine decarboxylase proenzyme 0.068 0.3954 0.5164
Schistosoma mansoni biogenic amine receptor 0.0042 0.0056 0.003
Echinococcus multilocularis histone lysine N methyltransferase, H3 lysine 36 0.0135 0.0624 0.0801
Trypanosoma brucei histone-lysine n-methyltransferase 0.0163 0.0793 0.1089
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0042 0.0056 0.0047
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0056 0.0056
Echinococcus granulosus disco interacting protein 2 0.0488 0.2778 0.3624
Mycobacterium ulcerans S-adenosyl-L-homocysteine hydrolase 0.0252 0.1337 0.0694
Plasmodium falciparum S-adenosylmethionine decarboxylase/ornithine decarboxylase 0.0331 0.1821 0.2453
Echinococcus granulosus g-protein coupled receptor 0.0042 0.0056 0.0056
Toxoplasma gondii S-Adenosyl homocysteine hydrolase 0.0252 0.1337 0.1836
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.0056 0.0056
Mycobacterium tuberculosis Probable adenosylhomocysteinase SahH (S-adenosyl-L-homocysteine hydrolase) (adohcyase) 0.0252 0.1337 0.0835
Brugia malayi hypothetical protein 0.0042 0.0056 0.0061
Loa Loa (eye worm) melatonin receptor type 1A 0.0042 0.0056 0.0047
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0056 0.0056
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0042 0.0056 0.0056
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.0056 0.0056
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.0056 0.0056
Brugia malayi neuropeptide F receptor 0.0042 0.0056 0.0061
Echinococcus multilocularis purine nucleoside phosphorylase 0.0193 0.0977 0.1263
Loa Loa (eye worm) hypothetical protein 0.0939 0.554 0.6088
Schistosoma mansoni DNA (cytosine-5)-methyltransferase 0.0625 0.3621 0.4715
Echinococcus granulosus purine nucleoside phosphorylase 0.0193 0.0977 0.1263
Brugia malayi uridine phosphorylase family protein 0.0193 0.0977 0.1074
Echinococcus granulosus methylthioadenosine phosphorylase 0.1042 0.617 0.8069
Toxoplasma gondii phosphorylase family protein 0.0193 0.0977 0.1248
Trypanosoma cruzi spermidine synthase, putative 0.1141 0.6775 1
Trichomonas vaginalis purine nucleoside phosphorylase I, putative 0.0193 0.0977 0.092
Plasmodium falciparum histone-lysine N-methyltransferase, putative 0.0089 0.0338 0.0194
Schistosoma mansoni opsin-like receptor 0.0042 0.0056 0.003
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0193 0.0977 0.2323
Trichomonas vaginalis conserved hypothetical protein 0.0193 0.0977 0.092
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0193 0.0977 0.1363
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0193 0.0977 0.1363
Echinococcus granulosus g protein coupled receptor 0.0042 0.0056 0.0056
Trypanosoma brucei cytosine-specific DNA methylase, putative 0.0625 0.3621 0.5301
Brugia malayi G-protein coupled receptor 0.0042 0.0056 0.0061
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0056 0.003
Echinococcus granulosus uridine phosphorylase 1 0.0193 0.0977 0.1263
Schistosoma mansoni myosin xvIII 0.0042 0.0056 0.003
Brugia malayi hypothetical protein 0.0042 0.0056 0.0061
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Echinococcus multilocularis purine nucleoside phosphorylase 0.0193 0.0977 0.1263
Echinococcus granulosus allatostatin A receptor 0.0042 0.0056 0.0056
Toxoplasma gondii DNA methyltransferase 2, putative 0.0625 0.3621 0.5559
Echinococcus granulosus g protein coupled receptor 0.0042 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Leishmania major hypothetical protein, conserved 0.0163 0.0793 0.1089
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0056 0.0056
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0056 0.0056
Brugia malayi polybromodomain protein 0.0056 0.0141 0.0155
Schistosoma mansoni microtubule-associated protein tau 0.0725 0.4231 0.5516
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Echinococcus multilocularis metastasis associated protein MTA1 0.0056 0.0141 0.0167
Loa Loa (eye worm) hypothetical protein 0.0226 0.1176 0.1281
Brugia malayi putative neuropeptide receptor NPR1 0.0042 0.0056 0.0061
Brugia malayi Protein arginine N-methyltransferase 0.0166 0.0809 0.089
Chlamydia trachomatis AMP nucleosidase 0.0193 0.0977 0.5
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0042 0.0056 0.0056
Echinococcus granulosus neuropeptide Y receptor 0.0042 0.0056 0.0056
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0163 0.0793 0.1089
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0163 0.0796 0.0953
Schistosoma mansoni jumonji domain containing protein 0.0079 0.0281 0.0327
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0056 0.003
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0042 0.0056 0.0056
Trypanosoma brucei Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0163 0.0793 0.1089
Giardia lamblia Purine nucleoside phosphorylase lateral transfer candidate 0.0193 0.0977 0.5
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0056 0.0056
Echinococcus granulosus purine nucleoside phosphorylase 0.0193 0.0977 0.1263
Echinococcus multilocularis DNA methyltransferase 2, putative 0.0625 0.3621 0.4728
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Plasmodium falciparum DNA (cytosine-5)-methyltransferase 0.0625 0.3621 0.5195
Schistosoma mansoni SET domain protein 0.0137 0.0635 0.0791
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0193 0.0977 0.092
Trypanosoma cruzi MIZ/SP-RING zinc finger, putative 0.0121 0.0534 0.0703
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0056 0.0141 0.0142
Brugia malayi neuropeptide F receptor 0.0042 0.0056 0.0061
Trichomonas vaginalis origin recognition complex subunit, putative 0.0056 0.0141 0.0079
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0193 0.0977 0.2323
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0056 0.003
Brugia malayi hypothetical protein 0.0121 0.0534 0.0587
Echinococcus multilocularis metastasis associated protein 1 (mta1) 0.0056 0.0141 0.0167
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.1042 0.617 0.9099
Loa Loa (eye worm) hypothetical protein 0.0052 0.0116 0.0113
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Echinococcus granulosus tachykinin peptides receptor 99D 0.0042 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Brugia malayi sulfakinin receptor protein 0.0042 0.0056 0.0061
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0056 0.0056
Schistosoma mansoni shk1 kinase-binding protein 0.0068 0.0211 0.0234
Echinococcus granulosus histone lysine methyltransferase setb 0.0226 0.1176 0.1525
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0042 0.0056 0.0056
Brugia malayi ORL1-like opioid receptor 0.0042 0.0056 0.0061
Loa Loa (eye worm) S-adenosylmethionine decarboxylase proenzyme 0.068 0.3954 0.4341
Brugia malayi jmjC domain containing protein 0.0039 0.0033 0.0036
Echinococcus granulosus PWWP domain containing protein 2A 0.0121 0.0534 0.0683
Schistosoma mansoni purine nucleoside phosphorylase 0.0193 0.0977 0.124
Echinococcus multilocularis sex peptide receptor 0.0042 0.0056 0.0056
Echinococcus granulosus purine nucleoside phosphorylase 0.0193 0.0977 0.1263
Brugia malayi hypothetical protein 0.0042 0.0056 0.0061
Brugia malayi ELM2 domain containing protein 0.0056 0.0141 0.0155
Echinococcus granulosus peregrin 0.0151 0.072 0.0927
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0056 0.003
Loa Loa (eye worm) hypothetical protein 0.0072 0.0236 0.0246
Echinococcus multilocularis allatostatin A receptor 0.0042 0.0056 0.0056
Trypanosoma brucei S-adenosylmethionine decarboxylase proenzyme, putative 0.068 0.3954 0.5797
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0042 0.0056 0.003
Brugia malayi hypothetical protein 0.0042 0.0056 0.0061
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Toxoplasma gondii hypothetical protein 0.0163 0.0793 0.0949
Schistosoma mansoni adenosylhomocysteinase 0.0156 0.075 0.0943
Toxoplasma gondii histone lysine methyltransferase SET1 0.0071 0.0232 0.0035
Loa Loa (eye worm) hypothetical protein 0.0056 0.0141 0.0141
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0078 0.0274 0.0318
Leishmania major hypothetical protein, conserved 0.0163 0.0793 0.1089
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0056 0.0056
Schistosoma mansoni biogenic amine receptor 0.0042 0.0056 0.003
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0042 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Loa Loa (eye worm) PWWP domain-containing protein 0.0121 0.0534 0.0574
Echinococcus multilocularis histone lysine N methyltransferase E(z) 0.0304 0.1656 0.2154
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0193 0.0977 0.2323
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0042 0.0056 0.0061
Echinococcus multilocularis disco interacting protein 2 0.0488 0.2778 0.3624
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0056 0.0056
Toxoplasma gondii Purine nucleoside phosphorylase 0.0193 0.0977 0.1248
Schistosoma mansoni bromo adjacent homology domain containing 0.0056 0.0141 0.0142
Schistosoma mansoni adenosylhomocysteinase 0.0156 0.075 0.0943
Loa Loa (eye worm) hypothetical protein 0.0113 0.0485 0.052
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0184 0.0922 0.1191
Trypanosoma cruzi spermidine synthase, putative 0.1141 0.6775 1
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.0056 0.0056
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.01 0.0407 0.0516
Echinococcus granulosus 7tm_1 domain containing protein 0.0042 0.0056 0.0056
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0056 0.0056
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.0056 0.003
Brugia malayi Skb1 methyltransferase family protein 0.0068 0.0211 0.0232
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0056 0.0056
Onchocerca volvulus Purine nucleoside phosphorylase homolog 0.0193 0.0977 0.0926
Brugia malayi putative neuropeptide receptor 0.0042 0.0056 0.0061
Echinococcus multilocularis purine nucleoside phosphorylase 0.0193 0.0977 0.1263
Schistosoma mansoni neuropeptide receptor 0.0042 0.0056 0.003
Plasmodium falciparum purine nucleoside phosphorylase 0.0193 0.0977 0.1167
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0193 0.0977 0.2323
Brugia malayi NNMT/PNMT/TEMT family protein 0.0939 0.554 0.6093
Brugia malayi GnHR receptor homolog 0.0042 0.0056 0.0061
Schistosoma mansoni adenosylhomocysteinase 0.0252 0.1337 0.1714
Schistosoma mansoni hypothetical protein 0.0042 0.0056 0.003
Schistosoma mansoni neuropeptide f receptor 76f 0.0042 0.0056 0.003
Loa Loa (eye worm) SET domain-containing protein 0.0304 0.1656 0.181
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Trypanosoma cruzi transcription elongation factor-like protein, putative 0.0121 0.0534 0.0703
Schistosoma mansoni uridine phosphorylase 0.0193 0.0977 0.124
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0056 0.0056
Treponema pallidum uridine phosphorylase (udp) 0.0193 0.0977 0.5
Schistosoma mansoni hypothetical protein 0.0042 0.0056 0.003
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0193 0.0977 0.5
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0042 0.0056 0.0056
Echinococcus multilocularis peregrin 0.0151 0.072 0.0927
Brugia malayi Adenosylhomocysteinase 0.0252 0.1337 0.1471
Brugia malayi Histone-lysine N-methyltransferase, H3 lysine-79 specific 0.1283 0.7644 0.8408
Brugia malayi Carm1-pending protein 0.0152 0.0726 0.0798
Brugia malayi RE15519p 0.0042 0.0056 0.0061
Echinococcus granulosus histone h3 methyltransferase 0.1283 0.7644 1
Echinococcus multilocularis g protein coupled receptor 0.0042 0.0056 0.0056
Brugia malayi Disco-interacting protein 2 homolog 0.0488 0.2778 0.3056
Echinococcus multilocularis neuropeptide receptor A26 0.0042 0.0056 0.0056
Brugia malayi PWWP domain containing protein 0.0121 0.0534 0.0587
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0056 0.0056
Brugia malayi G-protein coupled receptor 0.0042 0.0056 0.0061
Loa Loa (eye worm) spermidine synthase 0.1141 0.6775 0.7449
Schistosoma mansoni adenoreceptor 0.0042 0.0056 0.003
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0056 0.0141 0.0142
Brugia malayi hypothetical protein 0.0385 0.2151 0.2366
Echinococcus granulosus adenosylhomocysteinase 0.0252 0.1337 0.1735
Loa Loa (eye worm) hypothetical protein 0.0062 0.0177 0.018
Leishmania major S-adenosylhomocysteine hydrolase 0.0252 0.1337 0.19
Entamoeba histolytica adenosylhomocysteinase, putative 0.0252 0.1337 0.3369
Echinococcus multilocularis cpg binding protein 0.0456 0.2585 0.3371
Echinococcus multilocularis g-protein coupled receptor 0.0042 0.0056 0.0056
Echinococcus multilocularis neuropeptide Y receptor 0.0042 0.0056 0.0056
Brugia malayi Dopamine receptor protein 2 0.0042 0.0056 0.0061
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0056 0.0056
Onchocerca volvulus 0.0121 0.0534 0.0481
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0042 0.0056 0.0056
Echinococcus multilocularis serotonin receptor 0.0042 0.0056 0.0056
Brugia malayi hypothetical protein 0.0385 0.2151 0.2366
Trypanosoma cruzi hypothetical protein, conserved 0.0121 0.0534 0.0703
Leishmania major S-adenosylmethionine decarboxylase 0.068 0.3954 0.5797
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0252 0.1337 0.1283
Trypanosoma cruzi protein arginine n-methyltransferase 7 0.0166 0.0809 0.1113
Onchocerca volvulus 0.0276 0.1484 0.1436
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Leishmania major arginine N-methyltransferase, type III, putative;with=GeneDB:Tb927.7.5490 0.0166 0.0809 0.1113
Loa Loa (eye worm) uridine phosphorylase 0.0193 0.0977 0.1062
Brugia malayi Tachykinin-like peptides receptor 99D 0.0042 0.0056 0.0061
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0056 0.0056
Schistosoma mansoni histone J3 methyltransferase 0.1283 0.7644 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0056 0.003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0056 0.0056
Giardia lamblia UPL-1 0.0193 0.0977 0.5
Brugia malayi hypothetical protein 0.0042 0.0056 0.0061
Toxoplasma gondii hypothetical protein 0.1071 0.6346 1
Echinococcus multilocularis uridine phosphorylase 1 0.0193 0.0977 0.1263
Trypanosoma cruzi histone-lysine N-methyltransferase, putative 0.0163 0.0793 0.1089
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.0042 0.0056 0.003
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0252 0.1337 0.19
Echinococcus multilocularis neuropeptide receptor 0.0042 0.0056 0.0056
Echinococcus granulosus purine nucleoside phosphorylase 0.0193 0.0977 0.1263
Echinococcus granulosus bromo adjacent y domain containing 1 0.0056 0.0141 0.0167
Loa Loa (eye worm) TYRA-2 protein 0.0042 0.0056 0.0047
Brugia malayi purine nucleoside phosphorylase I, inosine and guanosine-specific family protein 0.0193 0.0977 0.1074
Echinococcus granulosus metastasis associated protein MTA1 0.0056 0.0141 0.0167
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.0056 0.0056
Echinococcus multilocularis PWWP domain containing protein 2A 0.0121 0.0534 0.0683
Mycobacterium ulcerans spermidine synthase 0.0899 0.5294 0.8312
Onchocerca volvulus 0.0488 0.2778 0.2738
Echinococcus multilocularis orexin receptor type 2 0.0042 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Loa Loa (eye worm) protein arginine N-methyltransferase 0.0166 0.0809 0.0877
Echinococcus multilocularis fmrfamide receptor 0.0042 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.0056 0.0056
Schistosoma mansoni cpg binding protein 0.0454 0.2574 0.334
Echinococcus multilocularis G protein coupled receptor 139 0.0042 0.0056 0.0056
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0042 0.0056 0.0047
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Schistosoma mansoni methylthioadenosine phosphorylase 0.1042 0.617 0.8064
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0042 0.0056 0.0056
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0056 0.0056
Schistosoma mansoni neuropeptide receptor 0.0042 0.0056 0.003
Loa Loa (eye worm) hypothetical protein 0.0385 0.2151 0.2355
Schistosoma mansoni enhancer of zeste ezh 0.0304 0.1656 0.2133
Echinococcus granulosus polybromo 1 0.0056 0.0141 0.0167
Schistosoma mansoni hypothetical protein 0.0177 0.0879 0.1112
Mycobacterium tuberculosis Probable spermidine synthase SpeE (putrescine aminopropyltransferase) (aminopropyltransferase) (SPDSY) 0.0899 0.5294 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.0056 0.003
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0193 0.0977 0.092
Loa Loa (eye worm) neuropeptide F receptor 0.0042 0.0056 0.0047
Leishmania major hypothetical protein, conserved 0.0121 0.0534 0.0703
Echinococcus multilocularis somatostatin receptor 0.0042 0.0056 0.0056
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0042 0.0056 0.0061
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Echinococcus multilocularis purine nucleoside phosphorylase 0.0193 0.0977 0.1263
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0056 0.0056
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0042 0.0056 0.003
Echinococcus granulosus lysine specific demethylase 5A 0.0039 0.0033 0.0026
Trypanosoma cruzi spermidine synthase, putative 0.1141 0.6775 1
Echinococcus multilocularis neuropeptide receptor 0.0042 0.0056 0.0056
Schistosoma mansoni hypothetical protein 0.0042 0.0056 0.003
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0056 0.0056
Brugia malayi MTAP 0.1042 0.617 0.6787
Echinococcus multilocularis purine nucleoside phosphorylase 0.0193 0.0977 0.1263
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0056 0.003
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0042 0.0056 0.0047
Schistosoma mansoni neuropeptide receptor 0.0042 0.0056 0.003
Loa Loa (eye worm) hypothetical protein 0.0118 0.052 0.0559
Brugia malayi G protein-coupled receptor F59B2.13 0.0042 0.0056 0.0061
Trypanosoma brucei uridine phosphorylase 0.0193 0.0977 0.1363
Schistosoma mansoni amine GPCR 0.0042 0.0056 0.003
Echinococcus granulosus protein arginine N methyltransferase 5 0.0068 0.0211 0.0259
Brugia malayi Pre-SET motif family protein 0.152 0.9091 1
Echinococcus multilocularis lysine specific demethylase 5A 0.0037 0.0022 0.0012
Trypanosoma cruzi S-adenosylhomocysteine hydrolase, putative 0.0252 0.1337 0.19
Mycobacterium tuberculosis Probable 5'-methylthioadenosine phosphorylase Pnp (MTA phosphorylase) 0.0849 0.499 0.9297
Echinococcus multilocularis adenosylhomocysteinase 0.0252 0.1337 0.1735
Echinococcus multilocularis histone h3 methyltransferase 0.1283 0.7644 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0042 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Schistosoma mansoni purine nucleoside phosphorylase 0.0193 0.0977 0.124
Plasmodium vivax histone-lysine N-methyltransferase, putative 0.0089 0.0338 0.0194
Loa Loa (eye worm) adenosylhomocysteinase 0.0252 0.1337 0.1459
Echinococcus granulosus S adenosylmethionine decarboxylase proenzyme 0.068 0.3954 0.5164
Echinococcus granulosus histone lysine N methyltransferase H3 lysine 36 0.0135 0.0624 0.0801
Echinococcus multilocularis geminin 0.0177 0.0879 0.1135
Echinococcus granulosus neuropeptide receptor 0.0042 0.0056 0.0056
Schistosoma mansoni opsin-like receptor 0.0042 0.0056 0.003
Schistosoma mansoni amine GPCR 0.0042 0.0056 0.003
Brugia malayi hypothetical protein 0.0062 0.0177 0.0194
Entamoeba histolytica purine nucleoside phosphorylase, putative 0.0193 0.0977 0.2323
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0042 0.0056 0.003
Schistosoma mansoni protein arginine n-methyltransferase 0.0135 0.0625 0.0778
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Trypanosoma brucei protein arginine n-methyltransferase 7 0.0166 0.0809 0.1113
Echinococcus granulosus SET and MYND domain containing protein 3 0.0074 0.0248 0.0308
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.152 0.9091 1
Schistosoma mansoni hypothetical protein 0.0056 0.0141 0.0142
Brugia malayi SET domain containing protein 0.0073 0.0241 0.0265
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0056 0.003
Schistosoma mansoni amine GPCR 0.0042 0.0056 0.003
Echinococcus granulosus neuropeptide FF receptor 2 0.0042 0.0056 0.0056
Echinococcus granulosus protein arginine N methyltransferase 7 0.0166 0.0809 0.1043
Echinococcus multilocularis purine nucleoside phosphorylase 0.0193 0.0977 0.1263
Echinococcus granulosus neuropeptide s receptor 0.0042 0.0056 0.0056
Echinococcus granulosus histone lysine n methyltransferase suv420h1 0.0144 0.0674 0.0866
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.0056 0.0047
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0042 0.0056 0.0047
Trypanosoma cruzi nucleoside phosphorylase, putative 0.0193 0.0977 0.1363
Toxoplasma gondii histone arginine methyltransferase PRMT4/CARM1 0.0152 0.0726 0.0839
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0193 0.0977 0.092
Echinococcus granulosus microtubule associated protein 2 0.0725 0.4231 0.5528
Trypanosoma cruzi hypothetical protein, conserved 0.0121 0.0534 0.0703
Echinococcus granulosus sex peptide receptor 0.0042 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Echinococcus multilocularis bromo adjacent y domain containing 1 0.0056 0.0141 0.0167
Brugia malayi follicle stimulating hormone receptor 0.0042 0.0056 0.0061
Echinococcus granulosus hepatoma derived growth factor protein 0.0121 0.0534 0.0683
Trypanosoma brucei Protein arginine N-methyltransferase 1 catalytic subunit 0.0062 0.0177 0.0171
Leishmania major spermidine synthase 0.1141 0.6775 1
Brugia malayi larval opioid receptor 0.0042 0.0056 0.0061
Toxoplasma gondii phosphorylase family protein 0.0193 0.0977 0.1248
Leishmania major histone-lysine N-methyltransferase, putative 0.0163 0.0793 0.1089
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0193 0.0977 0.092
Echinococcus granulosus purine nucleoside phosphorylase 0.0193 0.0977 0.1263
Schistosoma mansoni histamine h1 receptor 0.0042 0.0056 0.003
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Entamoeba histolytica DNA (cytosine-5)-methyltransferase, putative 0.0625 0.3621 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0163 0.0796 0.1026
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Brugia malayi hypothetical protein 0.0042 0.0056 0.0061
Schistosoma mansoni growth hormone secretagogue receptor 0.0042 0.0056 0.003
Schistosoma mansoni biogenic amine (5HT) receptor 0.0042 0.0056 0.003
Echinococcus granulosus purine nucleoside phosphorylase 0.0193 0.0977 0.1263
Loa Loa (eye worm) hypothetical protein 0.1283 0.7644 0.8406
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0042 0.0056 0.003
Brugia malayi Spermidine synthase 0.1141 0.6775 0.7453
Trypanosoma brucei S-adenosylhomocysteine hydrolase, putative 0.0252 0.1337 0.19
Echinococcus multilocularis microtubule associated protein 2 0.0725 0.4231 0.5528
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0042 0.0056 0.0061
Plasmodium vivax SET domain protein, putative 0.0163 0.0796 0.0891
Schistosoma mansoni phd finger protein 0.0121 0.0534 0.0659
Echinococcus granulosus G protein coupled receptor 139 0.0042 0.0056 0.0056
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0079 0.028 0.022
Echinococcus granulosus biogenic amine 5HT receptor 0.0042 0.0056 0.0056
Echinococcus granulosus neuropeptide receptor A26 0.0042 0.0056 0.0056
Schistosoma mansoni metastasis-associated protein 1 (mta1) 0.0056 0.0141 0.0142
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0056 0.003
Loa Loa (eye worm) NNMT/PNMT/TEMT family protein 0.0939 0.554 0.6088
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0042 0.0056 0.0061
Schistosoma mansoni hypothetical protein 0.0177 0.0879 0.1112
Echinococcus granulosus alpha 1A adrenergic receptor 0.0042 0.0056 0.0056
Loa Loa (eye worm) jmjC domain-containing protein 0.0063 0.0181 0.0185
Echinococcus multilocularis G-protein coupled receptor, putative 0.0042 0.0056 0.0056
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0062 0.0177 0.0171
Echinococcus granulosus g protein coupled receptor 0.0042 0.0056 0.0056
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0042 0.0056 0.003
Echinococcus granulosus tm gpcr rhodopsin 0.0042 0.0056 0.0056
Treponema pallidum pfs protein (pfs) 0.0193 0.0977 0.5
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Brugia malayi hypothetical protein 0.0042 0.0056 0.0061
Echinococcus granulosus somatostatin receptor 0.0042 0.0056 0.0056
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0042 0.0056 0.0056
Loa Loa (eye worm) jmjC domain-containing protein 0.0039 0.0033 0.0022
Echinococcus granulosus neuropeptides capa receptor 0.0042 0.0056 0.0056
Loa Loa (eye worm) G-protein coupled receptor 0.0042 0.0056 0.0047
Schistosoma mansoni biogenic amine receptor 0.0042 0.0056 0.003
Brugia malayi Dopamine receptor protein 1 0.0042 0.0056 0.0061
Schistosoma mansoni amine GPCR 0.0042 0.0056 0.003
Trypanosoma cruzi methylthioadenosine phosphorylase, putative 0.1042 0.617 0.9099
Echinococcus granulosus purine nucleoside phosphorylase 0.0193 0.0977 0.1263
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0193 0.0977 0.092
Loa Loa (eye worm) hypothetical protein 0.0385 0.2151 0.2355
Schistosoma mansoni disco-interacting protein 2 (dip2) 0.0488 0.2778 0.3607
Echinococcus multilocularis histone arginine methyltransferase CARMER 0.0152 0.0726 0.0934
Schistosoma mansoni hypothetical protein 0.0121 0.0534 0.0659
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.068 0.3954 0.5797
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0042 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Entamoeba histolytica hypothetical protein 0.0193 0.0977 0.2323
Schistosoma mansoni opsin-like receptor 0.0042 0.0056 0.003
Plasmodium vivax spermidine synthase, putative 0.1141 0.6775 1
Trypanosoma cruzi Histone methylation protein DOT1, putative 0.0163 0.0793 0.1089
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0042 0.0056 0.0047
Brugia malayi hypothetical protein 0.0042 0.0056 0.0061
Echinococcus granulosus serotonin receptor 0.0042 0.0056 0.0056
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0056 0.003
Echinococcus multilocularis serotonin receptor 0.0042 0.0056 0.0056
Plasmodium falciparum spermidine synthase 0.1141 0.6775 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0042 0.0056 0.003
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0193 0.0977 0.092
Echinococcus multilocularis methylthioadenosine phosphorylase 0.1042 0.617 0.8069
Onchocerca volvulus 0.0135 0.0622 0.0569
Trypanosoma cruzi arginine N-methyltransferase, putative 0.0062 0.0177 0.0171
Trichomonas vaginalis set domain proteins, putative 0.1669 1 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Loa Loa (eye worm) CXXC zinc finger family protein 0.0454 0.2574 0.2822
Schistosoma mansoni cpg binding protein 0.0456 0.2585 0.3353
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0226 0.1176 0.1525
Loa Loa (eye worm) SET domain-containing protein 0.0144 0.0674 0.0728
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0042 0.0056 0.0061
Brugia malayi hypothetical protein 0.0042 0.0056 0.0061
Brugia malayi SET domain containing protein 0.0127 0.0575 0.0633
Echinococcus multilocularis rhodopsin orphan GPCR 0.0042 0.0056 0.0056
Echinococcus multilocularis histone lysine n methyltransferase suv420h1 0.0144 0.0674 0.0866
Schistosoma mansoni suppressor of variegation 4-20-related 0.0144 0.0674 0.0843
Brugia malayi Serotonin receptor 0.0042 0.0056 0.0061
Brugia malayi Serotonin receptor 0.0042 0.0056 0.0061
Leishmania major methylthioadenosine phosphorylase, putative 0.1042 0.617 0.9099
Loa Loa (eye worm) hypothetical protein 0.0939 0.554 0.6088
Entamoeba histolytica MTA/SAH nucleosidase, putative 0.0193 0.0977 0.2323
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0042 0.0056 0.003
Loa Loa (eye worm) hypothetical protein 0.0058 0.0151 0.0152
Brugia malayi AKH receptor 0.0042 0.0056 0.0061
Brugia malayi Dopamine receptor 0.0042 0.0056 0.0061
Echinococcus granulosus peptide allatostatin:somatostatin 0.0042 0.0056 0.0056
Echinococcus granulosus DNA methyltransferase 2, putative 0.0625 0.3621 0.4728
Trypanosoma cruzi transcription elongation factor s-II, putative 0.0121 0.0534 0.0703
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0042 0.0056 0.0056
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0056 0.0056
Echinococcus multilocularis neuropeptide s receptor 0.0042 0.0056 0.0056
Schistosoma mansoni methylthioadenosine phosphorylase 0.0193 0.0977 0.124
Trichomonas vaginalis CDC6, putative 0.0056 0.0141 0.0079
Mycobacterium ulcerans 5'-methylthioadenosine phosphorylase 0.1042 0.617 1
Schistosoma mansoni hepatoma derived growth factor 0.0121 0.0534 0.0659
Onchocerca volvulus 0.0385 0.2151 0.2107
Toxoplasma gondii hypothetical protein 0.0121 0.0534 0.0527
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0163 0.0796 0.1003
Echinococcus granulosus orexin receptor type 2 0.0042 0.0056 0.0056
Echinococcus granulosus metastasis associated protein 1 mta1 0.0056 0.0141 0.0167
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0042 0.0056 0.0056
Trichomonas vaginalis conserved hypothetical protein 0.0193 0.0977 0.092
Trypanosoma cruzi Histone-lysine N-methyltransferase, H3 lysine-76 specific 0.0163 0.0793 0.1089
Echinococcus multilocularis neuropeptide FF receptor 2 0.0042 0.0056 0.0056
Trypanosoma brucei Histone methylation protein DOT1, putative 0.0163 0.0793 0.1089
Plasmodium vivax purine nucleoside phosphorylase, putative 0.0193 0.0977 0.1167
Echinococcus granulosus 7TM GPCR rhodopsin 0.0042 0.0056 0.0056
Echinococcus multilocularis hepatoma derived growth factor protein 0.0121 0.0534 0.0683
Trypanosoma cruzi S-adenosylmethionine decarboxylase proenzyme, putative 0.068 0.3954 0.5797
Trypanosoma cruzi arginine N-methyltransferase, type III 0.0166 0.0809 0.1113
Schistosoma mansoni amine GPCR 0.0042 0.0056 0.003
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Brugia malayi GATA zinc finger family protein 0.0056 0.0141 0.0155
Echinococcus multilocularis protein arginine N methyltransferase 5 0.0068 0.0211 0.0259
Plasmodium vivax DNA (cytosine-5)-methyltransferase, putative 0.0625 0.3621 0.5195
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.1071 0.6346 0.9346
Echinococcus granulosus arginine glutamic acid dipeptide RE repeats 0.0056 0.0141 0.0167
Schistosoma mansoni hypothetical protein 0.0121 0.0534 0.0659
Schistosoma mansoni protein arginine n-methyltransferase 0.0152 0.0726 0.0911
Echinococcus multilocularis spermidine synthase 0.1141 0.6775 0.8862
Trypanosoma brucei S-adenosylmethionine decarboxylase 0.068 0.3954 0.5797
Trichomonas vaginalis adenosylhomocysteinase, putative 0.0252 0.1337 0.1283
Loa Loa (eye worm) hypothetical protein 0.0056 0.0141 0.0141
Brugia malayi G protein-coupled receptor 0.0042 0.0056 0.0061
Brugia malayi S-adenosylmethionine decarboxylase proenzyme 0.068 0.3954 0.4349
Mycobacterium leprae putative S-adenosyl-L-homocysteine hydrolase SahH 0.0252 0.1337 1
Giardia lamblia 5-methylthioadenosine nucleosidase, S-adenosylhomocysteine nucleosidase 0.0193 0.0977 0.5
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Trypanosoma brucei transcription elongation factor s-II, putative 0.0121 0.0534 0.0703
Echinococcus granulosus purine nucleoside phosphorylase 0.0193 0.0977 0.1263
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Schistosoma mansoni polybromo-1 0.0056 0.0141 0.0142
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0056 0.003
Brugia malayi SET domain containing protein 0.0304 0.1656 0.1822
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0226 0.1176 0.1503
Schistosoma mansoni hypothetical protein 0.0054 0.0129 0.0127
Toxoplasma gondii C-5 cytosine-specific DNA methylase superfamily protein 0.0625 0.3621 0.5559
Echinococcus granulosus geminin 0.0177 0.0879 0.1135
Loa Loa (eye worm) hypothetical protein 0.0121 0.0534 0.0574
Schistosoma mansoni hypothetical protein 0.0121 0.0534 0.0659
Schistosoma mansoni neuropeptide F-like receptor 0.0042 0.0056 0.003
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0042 0.0056 0.003
Echinococcus multilocularis polybromo 1 0.0056 0.0141 0.0167
Echinococcus granulosus neuropeptide receptor 0.0042 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Trypanosoma brucei spermidine synthase 0.1141 0.6775 1
Echinococcus multilocularis neuropeptides capa receptor 0.0042 0.0056 0.0056
Echinococcus granulosus cpg binding protein 0.0456 0.2585 0.3371
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0042 0.0056 0.0056
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Echinococcus granulosus fmrfamide receptor 0.0042 0.0056 0.0056
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0042 0.0056 0.0056
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0042 0.0056 0.0056
Entamoeba histolytica hypothetical protein 0.0121 0.0534 0.1038
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0042 0.0056 0.003
Schistosoma mansoni adenosylhomocysteinase 0.0156 0.075 0.0943
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0042 0.0056 0.003
Echinococcus granulosus rhodopsin orphan GPCR 0.0042 0.0056 0.0056
Entamoeba histolytica Skb1 methyltransferase, putative 0.0068 0.0211 0.0099
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0042 0.0056 0.003
Onchocerca volvulus 0.0454 0.2574 0.2533
Echinococcus multilocularis fmrfamide receptor 0.0042 0.0056 0.0056
Brugia malayi hypothetical protein 0.0042 0.0056 0.0061
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0276 0.1484 0.1907
Echinococcus multilocularis SET and MYND domain containing protein 3 0.0074 0.0248 0.0308
Loa Loa (eye worm) hypothetical protein 0.0042 0.0056 0.0047
Plasmodium vivax S-adenosylmethionine decarboxylase-ornithine decarboxylase, putative 0.0331 0.1821 0.2453
Loa Loa (eye worm) Skb1 methyltransferase 0.0068 0.0211 0.0218
Echinococcus multilocularis PWWP domain containing protein 2A 0.0121 0.0534 0.0683
Loa Loa (eye worm) S-methyl-5'-thioadenosine phosphorylase MTAP 0.1042 0.617 0.6783
Echinococcus granulosus histone lysine N methyltransferase Ez 0.0304 0.1656 0.2154
Echinococcus granulosus PWWP domain containing protein 2A 0.0121 0.0534 0.0683
Schistosoma mansoni neuropeptide receptor 0.0042 0.0056 0.003
Schistosoma mansoni cpg binding protein 0.0456 0.2585 0.3353
Brugia malayi jmjC domain containing protein 0.01 0.0407 0.0447
Trichomonas vaginalis purine nucleoside phosphorylase, putative 0.0193 0.0977 0.092
Brugia malayi SET domain containing protein 0.0144 0.0674 0.0741

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 100 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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