TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 424.887 | Formula: C22H24ClF3N2O
H donors: 1 H acceptors: 1 LogP: 5.02 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: O=C(NC(C(F)(F)F)c1ccc(cc1)Cl)CCN1CCC(CC1)c1ccccc1
InChi: 1S/C22H24ClF3N2O/c23-19-8-6-18(7-9-19)21(22(24,25)26)27-20(29)12-15-28-13-10-17(11-14-28)16-4-2-1-3-5-16/h1-9,17,21H,10-15H2,(H,27,29)
InChiKey: HCBGHLFVHFXNAF-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	prolylcarboxypeptidase (angiotensinase C)	Starlite/ChEMBL	References
Mus musculus	prolylcarboxypeptidase (angiotensinase C)	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma japonicum	IPR008758,Peptidase S28,domain-containing	Get druggable targets OG5_130246	All targets in OG5_130246
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130246	All targets in OG5_130246
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	Get druggable targets OG5_130246	All targets in OG5_130246
Schistosoma japonicum	IPR008758,Peptidase S28,domain-containing	Get druggable targets OG5_130246	All targets in OG5_130246
Schistosoma mansoni	lysosomal Pro-Xaa carboxypeptidase (S28 family)	Get druggable targets OG5_130246	All targets in OG5_130246
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	Get druggable targets OG5_130246	All targets in OG5_130246
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130246	All targets in OG5_130246
Schistosoma japonicum	ko:K01285 lysosomal Pro-X carboxypeptidase [EC3.4.16.2], putative	Get druggable targets OG5_130246	All targets in OG5_130246
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_130246	All targets in OG5_130246
Brugia malayi	Serine carboxypeptidase S28 family protein	Get druggable targets OG5_130246	All targets in OG5_130246

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Trypanosoma cruzi	serine carboxypeptidase S28, putative	prolylcarboxypeptidase (angiotensinase C)	496 aa	414 aa	24.1 %
Trypanosoma cruzi	serine carboxypeptidase S28, putative	prolylcarboxypeptidase (angiotensinase C)	491 aa	402 aa	24.1 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	nuclear hormone receptor	0.0271	0.5013	0.5013
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.0271	0.5013	0.528
Brugia malayi	Carboxylesterase family protein	0.0083	0.1132	0.1132
Onchocerca volvulus	Protein ultraspiracle homolog	0.0271	0.5013	1
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0083	0.1132	0.5
Echinococcus granulosus	neurogenic locus notch protein	0.0049	0.0432	0.0455
Echinococcus granulosus	sodium and chloride dependent glycine	0.0043	0.0324	0.0341
Brugia malayi	laminin alpha chain	0.0049	0.0432	0.0432
Brugia malayi	hypothetical protein	0.0128	0.2065	0.2065
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.0271	0.5013	0.5013
Brugia malayi	Protein kinase domain containing protein	0.005	0.0468	0.0468
Onchocerca volvulus	Chorion peroxidase homolog	0.0096	0.1401	0.2795
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0169	0.0178
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0232	0.4208	0.4431
Brugia malayi	Protein kinase domain containing protein	0.0044	0.0335	0.0335
Schistosoma mansoni	hypothetical protein	0.0138	0.2271	0.2392
Brugia malayi	photoreceptor-specific nuclear receptor	0.0271	0.5013	0.5013
Loa Loa (eye worm)	intermediate filament protein	0.0028	0.0018	0.0019
Onchocerca volvulus		0.0083	0.1132	0.2258
Schistosoma mansoni	laminin gamma-3 chain	0.0067	0.0802	0.0844
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.0271	0.5013	0.528
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.0271	0.5013	1
Brugia malayi	hypothetical protein	0.0143	0.238	0.238
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0271	0.5013	0.528
Echinococcus granulosus	slit 2 protein	0.0067	0.0802	0.0844
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.0049	0.0441	1
Loa Loa (eye worm)	TK/EGFR protein kinase	0.0158	0.2673	0.2815
Echinococcus granulosus	mitogen activated protein kinase 14	0.0133	0.2169	0.2284
Loa Loa (eye worm)	animal heme peroxidase	0.0096	0.1401	0.1475
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0271	0.5013	0.5013
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.0049	0.0441	1
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0043	0.0324	0.0341
Schistosoma mansoni	cell polarity protein	0.0049	0.0432	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0143	0.238	0.2507
Brugia malayi	Serine protease Z688.6 precursor	0.0049	0.0441	0.0441
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0083	0.1132	0.1192
Loa Loa (eye worm)	hypothetical protein	0.0143	0.238	0.2507
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1401	0.1475
Schistosoma mansoni	ankyrin 23/unc44	0.0043	0.0325	0.0342
Schistosoma mansoni	peroxidasin	0.0096	0.1401	0.1475
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.0271	0.5013	0.528
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.0271	0.5013	0.528
Echinococcus multilocularis	ankyrin repeat and death domain containing protein	0.0043	0.0325	0.0342
Onchocerca volvulus		0.0043	0.0324	0.0646
Echinococcus granulosus	pikachurin	0.0049	0.0432	0.0455
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.0271	0.5013	0.528
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1132	0.1192
Brugia malayi	Animal haem peroxidase family protein	0.0096	0.1401	0.1401
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.0225	0.4054	0.4269
Onchocerca volvulus		0.0049	0.0441	0.0879
Schistosoma mansoni	nuclear hormone receptor	0.0271	0.5013	0.528
Loa Loa (eye worm)	hypothetical protein	0.0143	0.238	0.2507
Loa Loa (eye worm)	hypothetical protein	0.0128	0.2065	0.2174
Brugia malayi	Intermediate filament tail domain containing protein	0.0028	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0432	0.0455
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0043	0.0324	0.0341
Brugia malayi	Uncoordinated protein 44	0.0043	0.0325	0.0325
Echinococcus multilocularis	neurogenic locus notch protein	0.0049	0.0432	0.0455
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1132	0.1192
Echinococcus multilocularis	slit 2 protein	0.0067	0.0802	0.0844
Schistosoma mansoni	nuclear receptor	0.0128	0.2065	0.2174
Schistosoma mansoni	jun-related protein	0.0138	0.2271	0.2392
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0128	0.2065	0.2174
Echinococcus granulosus	netrin receptor unc 5	0.0043	0.0325	0.0342
Onchocerca volvulus	Peroxidasin homolog	0.0096	0.1401	0.2795
Mycobacterium tuberculosis	Carboxylesterase LipT	0.0083	0.1132	0.5
Onchocerca volvulus	Peroxidasin homolog	0.0096	0.1401	0.2795
Echinococcus multilocularis	sodium dependent neurotransmitter transporter	0.0043	0.0324	0.0341
Echinococcus granulosus	neuroligin	0.0083	0.1132	0.1192
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1132	0.1192
Echinococcus multilocularis	insulin receptor	0.005	0.0468	0.0492
Brugia malayi	hypothetical protein	0.0133	0.2176	0.2176
Echinococcus granulosus	sodium and chloride dependent glycine	0.0043	0.0324	0.0341
Mycobacterium ulcerans	carboxylesterase, LipT	0.0083	0.1132	0.5
Schistosoma mansoni	hypothetical protein	0.0036	0.0169	0.0178
Brugia malayi	Animal haem peroxidase family protein	0.0096	0.1401	0.1401
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0271	0.5013	0.5013
Onchocerca volvulus		0.0096	0.1401	0.2795
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0043	0.0324	0.0341
Brugia malayi	Carboxylesterase family protein	0.0489	0.9496	0.9496
Loa Loa (eye worm)	hypothetical protein	0.0128	0.2065	0.2174
Schistosoma mansoni	tyrosine kinase	0.0084	0.1155	0.1216
Brugia malayi	nuclear receptor NHR-88	0.0271	0.5013	0.5013
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.0271	0.5013	0.528
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0169	0.0178
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0143	0.238	0.2507
Echinococcus granulosus	mitogen activated protein kinase 11	0.0133	0.2169	0.2284
Loa Loa (eye worm)	hypothetical protein	0.0489	0.9496	1
Brugia malayi	laminin-like protein K08C7.3 precursor	0.0049	0.0432	0.0432
Schistosoma mansoni	family S28 unassigned peptidase (S28 family)	0.0049	0.0441	0.0464
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0043	0.0324	0.0341
Brugia malayi	Serine carboxypeptidase S28 family protein	0.0225	0.4054	0.4054
Echinococcus multilocularis	para nitrobenzyl esterase	0.0083	0.1132	0.1192
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0043	0.0324	0.0341
Loa Loa (eye worm)	norepinephrine transporter	0.0255	0.4688	0.4936
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0324	0.0341
Onchocerca volvulus		0.0083	0.1132	0.2258
Loa Loa (eye worm)	hypothetical protein	0.0255	0.4688	0.4936
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0169	0.0178
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.0271	0.5013	0.528
Echinococcus multilocularis	jun protein	0.017	0.2926	0.3081
Loa Loa (eye worm)	animal heme peroxidase	0.0096	0.1401	0.1475
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.0271	0.5013	0.5013
Schistosoma mansoni	nuclear receptor nhr-48	0.0128	0.2065	0.2174
Schistosoma mansoni	chondroitin sulfate proteoglycan-related	0.0049	0.0432	0.0455
Echinococcus granulosus	jun protein	0.017	0.2926	0.3081
Echinococcus granulosus	serotonin transporter	0.0255	0.4688	0.4936
Loa Loa (eye worm)	hypothetical protein	0.0225	0.4054	0.4269
Echinococcus granulosus	ecdysone induced protein 78C	0.0271	0.5013	0.528
Loa Loa (eye worm)	hypothetical protein	0.0128	0.2065	0.2174
Echinococcus multilocularis	family S9 non peptidase ue (S09 family)	0.0083	0.1132	0.1192
Brugia malayi	ecdysone receptor	0.0128	0.2065	0.2065
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0441	0.0464
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0133	0.2169	0.2284
Loa Loa (eye worm)	hypothetical protein	0.0271	0.5013	0.528
Schistosoma mansoni	tyrosine kinase	0.0158	0.2673	0.2815
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1132	0.1192
Brugia malayi	intermediate filament protein	0.0028	0.0018	0.0018
Loa Loa (eye worm)	hypothetical protein	0.0271	0.5013	0.528
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0043	0.0324	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1401	0.1475
Plasmodium falciparum	transporter, putative	0.0043	0.0324	0.5
Schistosoma mansoni	sodium/chloride dependent transporter	0.0255	0.4688	0.4936
Schistosoma mansoni	coup transcription factor	0.0271	0.5013	0.528
Treponema pallidum	sodium- and chloride- dependent transporter	0.0255	0.4688	0.5
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0122	0.1934	0.2036
Brugia malayi	nuclear receptor RXR	0.0143	0.238	0.238
Loa Loa (eye worm)	hypothetical protein	0.0128	0.2065	0.2174
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0128	0.2065	0.2174
Onchocerca volvulus		0.0133	0.2176	0.4339
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1401	0.1475
Echinococcus multilocularis	ecdysone induced protein 78C	0.0271	0.5013	0.528
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.0271	0.5013	0.5013
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0043	0.0324	0.0341
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0122	0.1934	0.2036
Brugia malayi	nuclear receptor RXR	0.0128	0.2065	0.2065
Brugia malayi	Blistered cuticle protein 3	0.0096	0.1401	0.1401
Schistosoma mansoni	lamin	0.0028	0.0018	0.0019
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.0376	0.7156	0.7536
Loa Loa (eye worm)	hypothetical protein	0.0143	0.238	0.2507
Onchocerca volvulus		0.0043	0.0324	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0067	0.0802	0.0844
Echinococcus multilocularis	mitogen activated protein kinase 14	0.0133	0.2169	0.2284
Onchocerca volvulus		0.0255	0.4688	0.935
Onchocerca volvulus	Bile acid receptor homolog	0.0271	0.5013	1
Brugia malayi	Carboxylesterase family protein	0.0083	0.1132	0.1132
Echinococcus granulosus	family S9 non peptidase ue S09 family	0.0083	0.1132	0.1192
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1401	0.1475
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0128	0.2065	0.2174
Loa Loa (eye worm)	carboxylesterase	0.0083	0.1132	0.1192
Loa Loa (eye worm)	hypothetical protein	0.0271	0.5013	0.528
Echinococcus multilocularis	epidermal growth factor receptor	0.0158	0.2673	0.2815
Brugia malayi	nuclear receptor NHR-88	0.0128	0.2065	0.2065
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0128	0.2065	0.2065
Schistosoma mansoni	neuroligin 3 (S09 family)	0.0083	0.1132	0.1192
Schistosoma mansoni	slit	0.0067	0.0802	0.0844
Echinococcus multilocularis	neuroligin	0.0083	0.1132	0.1192
Schistosoma mansoni	lamin	0.0028	0.0018	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0324	0.0341
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0043	0.0324	0.0341
Giardia lamblia	Thymus-specific serine protease precursor	0.0049	0.0441	0.5
Loa Loa (eye worm)	animal heme peroxidase	0.0096	0.1401	0.1475
Loa Loa (eye worm)	acetylcholinesterase 1	0.0489	0.9496	1
Echinococcus granulosus	voltage gated sodium channel Nav1 alpha subunit	0.009	0.1277	0.1345
Echinococcus multilocularis	sodium:chloride dependent neurotransmitter	0.0043	0.0324	0.0341
Brugia malayi	Nuclear hormone receptor E75	0.0128	0.2065	0.2065
Loa Loa (eye worm)	hypothetical protein	0.0128	0.2065	0.2174
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.0225	0.4054	0.4269
Schistosoma mansoni	zinc finger protein	0.0128	0.2065	0.2174
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0271	0.5013	0.5013
Trypanosoma brucei	mitogen-activated protein kinase 3, putative	0.0133	0.2169	0.5
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1401	0.1475
Onchocerca volvulus	Peroxidase homolog	0.0096	0.1401	0.2795
Loa Loa (eye worm)	hypothetical protein	0.0271	0.5013	0.528
Echinococcus multilocularis	peroxidasin	0.0096	0.1401	0.1475
Onchocerca volvulus	Netrin receptor homolog	0.0043	0.0325	0.0647
Schistosoma mansoni	tyrosine kinase	0.005	0.0468	0.0492
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.0271	0.5013	0.528
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.0271	0.5013	0.528
Echinococcus granulosus	FTZ F1 alpha	0.0271	0.5013	0.528
Brugia malayi	hypothetical protein	0.0096	0.1401	0.1401
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0393	0.7515	0.7914
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0489	0.9496	1
Schistosoma mansoni	sodium-dependent amino acid transporter	0.0043	0.0324	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1401	0.1475
Brugia malayi	nuclear receptor NHR-67	0.0128	0.2065	0.2065
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0043	0.0325	0.0325
Echinococcus multilocularis	FTZ F1 alpha	0.0271	0.5013	0.528
Echinococcus multilocularis	nuclear factor of activated T cells 5	0.0222	0.4005	0.4218
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.0271	0.5013	0.528
Brugia malayi	Animal haem peroxidase family protein	0.0096	0.1401	0.1401
Schistosoma mansoni	tyrosine kinase	0.0084	0.1155	0.1216
Loa Loa (eye worm)	carboxylesterase	0.0083	0.1132	0.1192
Giardia lamblia	Serine peptidase, putative	0.0049	0.0441	0.5
Echinococcus granulosus	intermediate filament protein	0.0028	0.0018	0.0019
Brugia malayi	Nuclear hormone receptor-like 1	0.0143	0.238	0.238
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1132	0.1192
Schistosoma mansoni	thyroid hormone receptor	0.0393	0.7515	0.7914
Echinococcus multilocularis	acetylcholinesterase	0.0489	0.9496	1
Echinococcus multilocularis	lamin	0.0028	0.0018	0.0019
Schistosoma mansoni	netrin receptor unc5	0.0043	0.0325	0.0342
Echinococcus granulosus	ankyrin repeat and death domain containing protein	0.0043	0.0325	0.0342
Schistosoma mansoni	hypothetical protein	0.0043	0.0325	0.0342
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0324	0.0341
Schistosoma mansoni	lipoxygenase	0.0058	0.0632	0.0665
Onchocerca volvulus		0.0083	0.1132	0.2258
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1401	0.1475
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1401	0.1475
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.0271	0.5013	0.528
Echinococcus multilocularis	Ankyrin	0.0044	0.0332	0.035
Chlamydia trachomatis	Ssodium-dependent amino acid transporter	0.0043	0.0324	0.5
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0043	0.0324	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0271	0.5013	0.528
Echinococcus granulosus	sodium dependent neurotransmitter transporter	0.0043	0.0324	0.0341
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.005	0.0468	0.0492
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0043	0.0324	0.0324
Echinococcus granulosus	sodium channel protein	0.009	0.1277	0.1345
Schistosoma mansoni	peroxidasin	0.0096	0.1401	0.1475
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.0271	0.5013	0.5013
Echinococcus granulosus	thyroid hormone receptor alpha	0.0128	0.2065	0.2174
Schistosoma mansoni	norepinephrine/norepinephrine transporter	0.0255	0.4688	0.4936
Loa Loa (eye worm)	hypothetical protein	0.0271	0.5013	0.528
Brugia malayi	Serine protease Z688.6 precursor	0.0049	0.0441	0.0441
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0143	0.238	0.2507
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.0271	0.5013	0.5013
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0128	0.2065	0.2174
Echinococcus multilocularis	Lysosomal Pro X carboxypeptidase	0.0049	0.0441	0.0464
Trichomonas vaginalis	spcc417.12 protein, putative	0.0083	0.1132	1
Brugia malayi	Nuclear hormone receptor E75	0.0128	0.2065	0.2065
Brugia malayi	Steroid receptor seven-up type 2	0.0271	0.5013	0.5013
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1401	0.1475
Loa Loa (eye worm)	hypothetical protein	0.0225	0.4054	0.4269
Loa Loa (eye worm)	hypothetical protein	0.0225	0.4054	0.4269
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0128	0.2065	0.2174
Plasmodium falciparum	amino acid transporter, putative	0.0043	0.0324	0.5
Echinococcus multilocularis	musashi	0.0028	0.0018	0.0019
Onchocerca volvulus	Peroxidase homolog	0.0096	0.1401	0.2795
Schistosoma mansoni	hypothetical protein	0.0122	0.1934	0.2036
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.0271	0.5013	0.528
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1401	0.1475
Echinococcus granulosus	lamin dm0	0.0028	0.0018	0.0019
Trichomonas vaginalis	carboxylesterase domain containing protein, putative	0.0083	0.1132	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1132	0.1192
Brugia malayi	hypothetical protein	0.0043	0.0324	0.0324
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0018	0.0019
Leishmania major	mitogen-activated protein kinase 3, putative,map kinase 3, putative	0.0133	0.2169	1
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0128	0.2065	0.2174
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0043	0.0324	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1401	0.1475
Schistosoma mansoni	tyrosine kinase	0.0085	0.1173	0.1236
Echinococcus granulosus	Basic leucine zipper bZIP transcription factor	0.017	0.2926	0.3081
Onchocerca volvulus		0.0028	0.0018	0.0036
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0271	0.5013	0.528
Loa Loa (eye worm)	hypothetical protein	0.0255	0.4688	0.4936
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0271	0.5013	0.528
Brugia malayi	Death domain containing protein	0.0043	0.0325	0.0325
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0255	0.4688	0.4688
Echinococcus multilocularis	epidermal growth factor receptor	0.0085	0.1173	0.1236
Onchocerca volvulus		0.0043	0.0324	0.0646
Loa Loa (eye worm)	hypothetical protein	0.0128	0.2065	0.2174
Schistosoma mansoni	sodium/chloride dependent transporter	0.0043	0.0324	0.0341
Loa Loa (eye worm)	CMGC/MAPK/P38 protein kinase	0.0133	0.2169	0.2284
Onchocerca volvulus	Dual oxidase homolog	0.0096	0.1401	0.2795
Loa Loa (eye worm)	hypothetical protein	0.0465	0.9	0.9478
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0128	0.2065	0.2174
Loa Loa (eye worm)	Sodium:neurotransmitter symporter family protein	0.0043	0.0324	0.0341
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.0271	0.5013	0.528
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0128	0.2065	0.2174
Schistosoma mansoni	RAR-like nuclear receptor	0.0271	0.5013	0.528
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0332	0.035
Loa Loa (eye worm)	DR-78	0.0128	0.2065	0.2174
Brugia malayi	hypothetical protein	0.0036	0.0169	0.0169
Loa Loa (eye worm)	carboxylesterase	0.0489	0.9496	1
Brugia malayi	ecdysteroid receptor	0.0271	0.5013	0.5013
Loa Loa (eye worm)	hypothetical protein	0.0128	0.2065	0.2174
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0133	0.2169	0.2284
Brugia malayi	EGF-like domain containing protein	0.0067	0.0802	0.0802
Schistosoma mansoni	nuclear hormone receptor	0.0128	0.2065	0.2174
Echinococcus multilocularis	sodium and chloride dependent glycine	0.0043	0.0324	0.0341
Loa Loa (eye worm)	blistered cuticle protein 3	0.0096	0.1401	0.1475
Loa Loa (eye worm)	hypothetical protein	0.0128	0.2065	0.2174
Schistosoma mansoni	acetylcholinesterase	0.0083	0.1132	0.1192
Brugia malayi	Sodium:neurotransmitter symporter family protein 1, putative	0.0043	0.0324	0.0324
Brugia malayi	nuclear hormone receptor family member odr-7	0.0128	0.2065	0.2065
Schistosoma mansoni	sodium/chloride dependent transporter	0.0044	0.0334	0.0352
Brugia malayi	steroid hormone receptor	0.0271	0.5013	0.5013
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.005	0.0468	0.0492
Echinococcus multilocularis	acetylcholinesterase	0.0489	0.9496	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.0271	0.5013	0.5013
Plasmodium vivax	hypothetical protein, conserved	0.0043	0.0324	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0128	0.2065	0.2174
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.0271	0.5013	0.528
Brugia malayi	bZIP transcription factor family protein	0.017	0.2926	0.2926
Brugia malayi	P38 map kinase family protein 2	0.0133	0.2169	0.2169
Brugia malayi	hypothetical protein	0.0083	0.1132	0.1132
Loa Loa (eye worm)	hypothetical protein	0.0128	0.2065	0.2174
Brugia malayi	orphan nuclear receptor NR2E1	0.0128	0.2065	0.2065
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.0085	0.1173	0.1236
Echinococcus granulosus	death domain containing protein	0.0043	0.0325	0.0342
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0143	0.238	0.2507
Echinococcus multilocularis	lamin dm0	0.0028	0.0018	0.0019
Onchocerca volvulus		0.0096	0.1401	0.2795
Plasmodium vivax	amine transporter, putative	0.0043	0.0324	0.5
Echinococcus multilocularis	BC026374 protein (S09 family)	0.0083	0.1132	0.1192
Loa Loa (eye worm)	hypothetical protein	0.0128	0.2065	0.2174
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0324	0.0341
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0043	0.0325	0.0342
Loa Loa (eye worm)	steroid hormone receptor	0.0271	0.5013	0.528
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0128	0.2065	0.4118
Schistosoma mansoni	thyroid hormone receptor	0.0393	0.7515	0.7914
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0128	0.2065	0.2174
Echinococcus granulosus	nuclear receptor nhr 48	0.0128	0.2065	0.2174
Loa Loa (eye worm)	animal heme peroxidase	0.0096	0.1401	0.1475
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0058	0.0632	0.0665
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.0271	0.5013	0.528
Onchocerca volvulus		0.0271	0.5013	1
Loa Loa (eye worm)	hypothetical protein	0.0128	0.2065	0.2174
Brugia malayi	Carboxylesterase family protein	0.0489	0.9496	0.9496
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0128	0.2065	0.2065
Brugia malayi	Carboxylesterase family protein	0.0083	0.1132	0.1132
Brugia malayi	conserved hypotetical protein	0.0128	0.2065	0.2065
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0128	0.2065	0.2174
Schistosoma mansoni	sodium/chloride dependent neurotransmitter transporter	0.0043	0.0324	0.0341
Echinococcus granulosus	carboxylesterase 5A	0.0489	0.9496	1
Loa Loa (eye worm)	abnormal epIthelia family member	0.0049	0.0432	0.0455
Loa Loa (eye worm)	solute carrier family 6 member 4	0.0255	0.4688	0.4936
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.0271	0.5013	0.528
Brugia malayi	Nuclear hormone receptor-like 1	0.0271	0.5013	0.5013
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.0271	0.5013	0.5013
Echinococcus multilocularis	nuclear receptor nhr 48	0.0128	0.2065	0.2174
Echinococcus multilocularis	pikachurin	0.0049	0.0432	0.0455
Loa Loa (eye worm)	TK/INSR protein kinase	0.005	0.0468	0.0492
Echinococcus multilocularis	netrin receptor unc 5	0.0043	0.0325	0.0342
Schistosoma mansoni	sodium-dependent neurotransmitter transporter	0.0043	0.0324	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1401	0.1475
Echinococcus granulosus	sodium:chloride dependent neurotransmitter	0.0043	0.0324	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0465	0.9	0.9478
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0007	0.0008
Brugia malayi	Animal haem peroxidase family protein	0.0096	0.1401	0.1401
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.0271	0.5013	0.5013
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0324	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0324	0.0341
Echinococcus granulosus	uncharacterized sodium dependent transporter	0.0043	0.0324	0.0341
Onchocerca volvulus		0.0128	0.2065	0.4118
Echinococcus granulosus	peroxidasin	0.0096	0.1401	0.1475
Echinococcus granulosus	epidermal growth factor receptor	0.0085	0.1173	0.1236
Schistosoma mansoni	steroid hormone receptor ad4bp	0.0271	0.5013	0.528
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription factor	0.017	0.2926	0.3081
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0325	0.0342
Echinococcus multilocularis	mitogen activated protein kinase 11	0.0133	0.2169	0.2284
Brugia malayi	nuclear hormone receptor	0.0128	0.2065	0.2065
Echinococcus granulosus	epidermal growth factor receptor	0.0158	0.2673	0.2815
Echinococcus granulosus	acetylcholinesterase	0.0489	0.9496	1
Echinococcus multilocularis	serotonin transporter	0.0255	0.4688	0.4936
Echinococcus granulosus	nuclear factor of activated T cells 5	0.0222	0.4005	0.4218
Echinococcus multilocularis	sodium channel protein	0.009	0.1277	0.1345
Brugia malayi	Animal haem peroxidase family protein	0.0096	0.1401	0.1401
Brugia malayi	Nuclear hormone receptor-like 1	0.0143	0.238	0.238
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0133	0.2169	1
Trypanosoma cruzi	mitogen-activated protein kinase 3, putative	0.0133	0.2169	1
Loa Loa (eye worm)	hypothetical protein	0.0143	0.238	0.2507
Echinococcus granulosus	para nitrobenzyl esterase	0.0083	0.1132	0.1192
Toxoplasma gondii	serine carboxypeptidase s28 protein	0.0049	0.0441	1
Loa Loa (eye worm)	hypothetical protein	0.0165	0.283	0.298
Brugia malayi	tailless protein	0.0128	0.2065	0.2065
Schistosoma mansoni	gliotactin	0.0083	0.1132	0.1192
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.0271	0.5013	0.528
Loa Loa (eye worm)	serotonin transporter b	0.0255	0.4688	0.4936
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0432	0.0455
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0128	0.2065	0.4118
Schistosoma mansoni	retinoblastoma-binding protein 4 (rbbp4)	0.0044	0.0332	0.035
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.0271	0.5013	0.528
Echinococcus granulosus	Lysosomal Pro X carboxypeptidase	0.0049	0.0441	0.0464
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0143	0.238	0.2507
Schistosoma mansoni	retinoic acid receptor RXR	0.0376	0.7156	0.7536
Brugia malayi	Carboxylesterase family protein	0.0083	0.1132	0.1132
Onchocerca volvulus		0.0083	0.1132	0.2258
Loa Loa (eye worm)	nuclear hormone receptor	0.0128	0.2065	0.2174
Brugia malayi	Sodium:neurotransmitter symporter family protein	0.0043	0.0324	0.0324
Schistosoma mansoni	lysosomal Pro-Xaa carboxypeptidase (S28 family)	0.0225	0.4054	0.4269
Entamoeba histolytica	serine carboxypeptidase (S28) family protein	0.0049	0.0441	1
Schistosoma mansoni	tyrosine kinase	0.005	0.0468	0.0492
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0271	0.5013	0.528
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0083	0.1132	0.1192
Onchocerca volvulus		0.0028	0.0018	0.0036
Schistosoma mansoni	family S9 non-peptidase homologue (S09 family)	0.0083	0.1132	0.1192
Schistosoma mansoni	tyrosine kinase	0.0084	0.1155	0.1216
Loa Loa (eye worm)	hypothetical protein	0.0043	0.0324	0.0341
Schistosoma mansoni	intermediate filament proteins	0.0028	0.0018	0.0019
Mycobacterium tuberculosis	POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT)	0.0083	0.1132	0.5
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0058	0.0632	0.0665
Onchocerca volvulus		0.0083	0.1132	0.2258
Brugia malayi	Peroxidasin	0.0096	0.1401	0.1401
Echinococcus granulosus	insulin receptor	0.005	0.0468	0.0492
Loa Loa (eye worm)	hypothetical protein	0.0271	0.5013	0.528
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.0271	0.5013	0.528
Echinococcus granulosus	Ankyrin	0.0044	0.0332	0.035
Brugia malayi	Furin-like cysteine rich region family protein	0.0158	0.2673	0.2673
Echinococcus granulosus	BC026374 protein S09 family	0.0083	0.1132	0.1192
Brugia malayi	hypothetical protein	0.0128	0.2065	0.2065
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.0271	0.5013	0.5013
Schistosoma mansoni	BC026374 protein (S09 family)	0.0083	0.1132	0.1192
Onchocerca volvulus		0.0096	0.1401	0.2795
Echinococcus multilocularis	uncharacterized sodium dependent transporter	0.0043	0.0324	0.0341
Loa Loa (eye worm)	hypothetical protein	0.0271	0.5013	0.528
Echinococcus multilocularis	carboxylesterase 5A	0.0489	0.9496	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.1132	0.1192
Loa Loa (eye worm)	hypothetical protein	0.0489	0.9496	1
Schistosoma mansoni	nuclear receptor	0.0128	0.2065	0.2174
Brugia malayi	hypothetical protein	0.0143	0.238	0.238
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0143	0.238	0.2507
Echinococcus granulosus	acetylcholinesterase	0.0489	0.9496	1
Loa Loa (eye worm)	hypothetical protein	0.0128	0.2065	0.2174
Echinococcus granulosus	lamin	0.0028	0.0018	0.0019
Schistosoma mansoni	tyrosine kinase	0.0085	0.1173	0.1236
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1401	0.1475
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.0271	0.5013	0.528
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0128	0.2065	0.2174
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0028	0.0018	0.0019
Loa Loa (eye worm)	hypothetical protein	0.0255	0.4688	0.4936
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.0271	0.5013	0.5013
Loa Loa (eye worm)	hypothetical protein	0.0128	0.2065	0.2174
Onchocerca volvulus		0.0128	0.2065	0.4118
Brugia malayi	Thrombospondin N-terminal -like domain containing protein	0.0049	0.0432	0.0432
Schistosoma mansoni	nuclear hormone receptor	0.0128	0.2065	0.2174
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1401	0.1475
Echinococcus multilocularis		0.0049	0.0435	0.0458
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0271	0.5013	0.528

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 1.4 nM	Inhibition of recombinant human PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assay	ChEMBL.	22079761
IC50 (binding)	= 14 nM	Inhibition of recombinant mouse PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assay	ChEMBL.	22079761
IC50 (binding)	= 70 nM	Inhibition of recombinant human PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assay	ChEMBL.	22079761

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1938519

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1597638