Detailed information for compound 159906

Basic information

Technical information
  • TDR Targets ID: 159906
  • Name: (2S,3S,4S)-2-[(1R)-2-amino-1-[(2S,3S,4R,5R)-5 -(2,4-dioxopyrimidin-1-yl)-4-hydroxy-3-methox yoxolan-2-yl]-2-oxoethoxy]-3,4-dihydroxy-N-te tradecyl-3,4-dihydro-2H-pyran-6-carboxamide
  • MW: 654.749 | Formula: C31H50N4O11
  • H donors: 6 H acceptors: 7 LogP: 2.36 Rotable bonds: 21
    Rule of 5 violations (Lipinski): 3
  • SMILES: CCCCCCCCCCCCCCNC(=O)C1=C[C@@H]([C@@H]([C@H](O1)O[C@H]([C@H]1O[C@H]([C@@H]([C@@H]1OC)O)n1ccc(=O)[nH]c1=O)C(=O)N)O)O
  • InChi: 1S/C31H50N4O11/c1-3-4-5-6-7-8-9-10-11-12-13-14-16-33-28(41)20-18-19(36)22(38)30(44-20)46-26(27(32)40)25-24(43-2)23(39)29(45-25)35-17-15-21(37)34-31(35)42/h15,17-19,22-26,29-30,36,38-39H,3-14,16H2,1-2H3,(H2,32,40)(H,33,41)(H,34,37,42)/t19-,22-,23+,24-,25-,26+,29+,30+/m0/s1
  • InChiKey: FZNKZWRXRXXUFG-LTRPPTTCSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S,3S,4S)-2-[(1R)-2-amino-1-[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-3-methoxy-tetrahydrofuran-2-yl]-2-oxo-ethoxy]-3,4-dihydroxy-N-tetradecyl-3,4-dihydro-2H-pyran-6-carboxamide
  • (2S,3S,4S)-2-[(1R)-2-amino-1-[(2S,3S,4R,5R)-5-(2,4-dioxo-1-pyrimidinyl)-4-hydroxy-3-methoxy-2-tetrahydrofuranyl]-2-oxoethoxy]-3,4-dihydroxy-N-tetradecyl-3,4-dihydro-2H-pyran-6-carboxamide
  • (2S,3S,4S)-2-[(1R)-2-azanyl-1-[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-3-methoxy-oxolan-2-yl]-2-oxo-ethoxy]-3,4-dihydroxy-N-tetradecyl-3,4-dihydro-2H-pyran-6-carboxamide
  • (2S,3S,4S)-2-[(1R)-2-amino-1-[(2S,3S,4R,5R)-5-(2,4-diketopyrimidin-1-yl)-4-hydroxy-3-methoxy-tetrahydrofuran-2-yl]-2-keto-ethoxy]-3,4-dihydroxy-N-myristyl-3,4-dihydro-2H-pyran-6-carboxamide
  • (4S,5S,6S)-6-[(1R)-2-amino-1-[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-3-methoxyoxolan-2-yl]-2-oxoethoxy]-4,5-dihydroxy-N-tetradecyl-5,6-dihydro-4H-pyran-2-carboxamide
  • (4S,5S,6S)-6-[(1R)-2-amino-1-[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-3-methoxy-tetrahydrofuran-2-yl]-2-oxo-ethoxy]-4,5-dihydroxy-N-tetradecyl-5,6-dihydro-4H-pyran-2-carboxamide
  • (4S,5S,6S)-6-[(1R)-2-amino-1-[(2S,3S,4R,5R)-5-(2,4-dioxo-1-pyrimidinyl)-4-hydroxy-3-methoxy-2-tetrahydrofuranyl]-2-oxoethoxy]-4,5-dihydroxy-N-tetradecyl-5,6-dihydro-4H-pyran-2-carboxamide
  • (4S,5S,6S)-6-[(1R)-2-amino-1-[(2S,3S,4R,5R)-5-(2,4-diketopyrimidin-1-yl)-4-hydroxy-3-methoxy-tetrahydrofuran-2-yl]-2-keto-ethoxy]-4,5-dihydroxy-N-myristyl-5,6-dihydro-4H-pyran-2-carboxamide
  • (4S,5S,6S)-6-[(1R)-2-amino-1-[(2S,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-4-hydroxy-3-methoxy-oxolan-2-yl]-2-oxo-ethoxy]-4,5-dihydroxy-N-tetradecyl-5,6-dihydro-4H-pyran-2-carboxamide
  • AIDS-189128
  • AIDS189128
  • (4S,5S,6S)-6-{(R)-1-Carbamoyl-1-[(2S,3S,4R,5R)-5-(2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-4-hydroxy-3-methoxy-tetrahydro-furan-2-yl]-methoxy}-4,5-dihydroxy-5,6-dihydro-4H-pyran-2-carboxylic acid tetradecylamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli phospho-N-acetylmuramoyl-pentapeptide transferase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Wolbachia endosymbiont of Brugia malayi phospho-N-acetylmuramoyl-pentapeptide-transferase Get druggable targets OG5_131597 All targets in OG5_131597
Mycobacterium ulcerans phospho-N-acetylmuramoyl-pentapeptide-transferase Get druggable targets OG5_131597 All targets in OG5_131597
Mycobacterium tuberculosis Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX Get druggable targets OG5_131597 All targets in OG5_131597
Mycobacterium leprae Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX Get druggable targets OG5_131597 All targets in OG5_131597
Treponema pallidum phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) Get druggable targets OG5_131597 All targets in OG5_131597
Chlamydia trachomatis phospho-N-acetylmuramoyl-pentapeptide-transferase Get druggable targets OG5_131597 All targets in OG5_131597
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0046
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.047 0.0614
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0024 0.0071 0.0093
Onchocerca volvulus 0.0042 0.0278 0.0506
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0028 0.0037
Echinococcus multilocularis glycine receptor subunit beta 0.0042 0.0278 0.0364
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0244 1
Brugia malayi glutathione reductase 0.0046 0.0323 0.0722
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0042 0.0278 0.0364
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0159
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0046
Onchocerca volvulus 0.0467 0.5112 1
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0028 0.0015
Entamoeba histolytica aminopeptidase, putative 0.0024 0.0071 0.2468
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0071 0.0093
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0623
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0028 0.0037
Onchocerca volvulus 0.002 0.0028 0.0015
Loa Loa (eye worm) TATA binding protein associated factor 0.0024 0.0071 0.0159
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0028 0.0037
Loa Loa (eye worm) hypothetical protein 0.0038 0.0228 0.0511
Brugia malayi hypothetical protein 0.0019 0.0021 0.0046
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0023 0.0058 0.0129
Echinococcus granulosus glycine receptor subunit alpha 1 0.0042 0.0278 0.0364
Echinococcus granulosus jumonji domain containing protein 0.0039 0.0249 0.0325
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0196 0.0439
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0063
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0014 0.0031
Echinococcus granulosus subfamily M12B unassigned peptidase 0.0018 0.0002 0.0003
Trypanosoma cruzi aminopeptidase, putative 0.0024 0.0071 0.2196
Loa Loa (eye worm) cytochrome P450 family protein 0.0037 0.0217 0.0486
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0042 0.0278 0.0364
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0071 0.0093
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0019 0.0021 0.0027
Trypanosoma brucei Aminopeptidase M1, putative 0.0024 0.0071 0.2196
Echinococcus granulosus glycine receptor subunit alpha 1 0.0042 0.0278 0.0364
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0028 0.0037
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0024 0.0071 0.2196
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0623
Chlamydia trachomatis phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0341 0.3677 0.5
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0024 0.0071 0.0112
Brugia malayi ephrin receptor 1 precursor 0.003 0.014 0.0314
Onchocerca volvulus 0.0059 0.047 0.0882
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0014 0.0014
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0071 0.0093
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0028 0.0015
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0071 0.0093
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0071 0.0093
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0028 0.0037
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0028 0.0037
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0024 0.0071 0.0112
Schistosoma mansoni nAChR subunit 0.0019 0.0021 0.0027
Brugia malayi Cation transporter family protein 0.0042 0.0278 0.0623
Brugia malayi jmjC domain containing protein 0.0034 0.019 0.0426
Schistosoma mansoni ephrin receptor 0.0063 0.0514 0.0671
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0042 0.0278 0.0364
Loa Loa (eye worm) PHD-finger family protein 0.0028 0.0122 0.0274
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0042 0.0278 0.0364
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.047 0.0614
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0014 0.0018
Schistosoma mansoni nAChR subunit 0.0042 0.0278 0.0364
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0028 0.0037
Echinococcus multilocularis pikachurin 0.0028 0.0119 0.0155
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0042 0.0278 0.0364
Onchocerca volvulus 0.0024 0.0071 0.0099
Mycobacterium ulcerans phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0896 1 1
Schistosoma mansoni ap endonuclease 0.0019 0.0014 0.0018
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0046
Onchocerca volvulus 0.0023 0.0058 0.0073
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0453 0.0453
Echinococcus granulosus histone acetyltransferase KAT2B 0.0043 0.0285 0.0372
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0023 0.0058 0.0075
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0046
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0042 0.0278 0.0623
Schistosoma mansoni nuclear hormone receptor 0.002 0.0028 0.0037
Brugia malayi PHD-finger family protein 0.0028 0.0122 0.0274
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0035 0.0196 0.0196
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0024 0.0071 0.0093
Echinococcus granulosus disintegrin and metalloproteinase 0.0018 0.0002 0.0003
Schistosoma mansoni thyroid hormone receptor 0.002 0.0028 0.0037
Echinococcus granulosus adam 17 protease 0.0196 0.2032 0.2656
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0028 0.0037
Loa Loa (eye worm) TK/EPH protein kinase 0.008 0.0707 0.1583
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.0992 0.0992
Echinococcus multilocularis nAChR subunit 0.0042 0.0278 0.0364
Echinococcus multilocularis disintegrin and metalloproteinase 0.0018 0.0002 0.0003
Echinococcus granulosus aminopeptidase N 0.0024 0.0071 0.0093
Brugia malayi hypothetical protein 0.0024 0.0071 0.0159
Echinococcus granulosus ephrin type A receptor 4 A 0.0063 0.0514 0.0671
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0623
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0323 0.0323
Toxoplasma gondii aminopeptidase n, putative 0.0024 0.0071 0.1509
Schistosoma mansoni neurotransmitter gated ion channel 0.0019 0.0021 0.0027
Echinococcus granulosus leukotriene A 4 hydrolase 0.023 0.2414 0.3156
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0042 0.0278 0.0364
Brugia malayi Cation transporter family protein 0.0042 0.0278 0.0623
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0028 0.0063
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.1125 0.1125
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0028 0.0037
Loa Loa (eye worm) hypothetical protein 0.0023 0.0058 0.0129
Leishmania major UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0038 0.0228 0.5044
Onchocerca volvulus 0.0042 0.0278 0.0506
Brugia malayi hypothetical protein 0.0206 0.2144 0.4798
Loa Loa (eye worm) CYP4Cod1 0.0035 0.0196 0.0439
Plasmodium vivax glutathione reductase, putative 0.0046 0.0323 0.6776
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0028 0.0037
Loa Loa (eye worm) hypothetical protein 0.0023 0.0058 0.0129
Loa Loa (eye worm) hypothetical protein 0.0028 0.0119 0.0266
Loa Loa (eye worm) hypothetical protein 0.0028 0.0122 0.0274
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0028 0.0063
Schistosoma mansoni aminopeptidase A (M01 family) 0.0024 0.0071 0.0093
Brugia malayi Pre-SET motif family protein 0.041 0.4468 1
Trypanosoma cruzi cytochrome P450, putative 0.0035 0.0196 0.6073
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0028 0.0063
Loa Loa (eye worm) hypothetical protein 0.0023 0.0058 0.0129
Brugia malayi ecdysteroid receptor 0.002 0.0028 0.0063
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0046
Brugia malayi Peptidase family M1 containing protein 0.0024 0.0071 0.0159
Echinococcus multilocularis nAChR subunit 0.0023 0.0058 0.0075
Brugia malayi hypothetical protein 0.0019 0.0021 0.0046
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0042 0.0278 0.0623
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0042 0.0278 0.0623
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0042 0.0278 0.0623
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0019 0.0021 0.0027
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0042 0.0278 0.0623
Schistosoma mansoni chondroitin sulfate proteoglycan-related 0.0028 0.0119 0.0155
Treponema pallidum phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) 0.0341 0.3677 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0159
Brugia malayi hypothetical protein 0.0019 0.0021 0.0046
Trypanosoma brucei cytochrome P450, putative 0.0035 0.0196 0.6073
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0093 0.0855 0.1118
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0042 0.0278 0.0623
Schistosoma mansoni nAChR subunit 0.0042 0.0278 0.0364
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.019 0.0249
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0042 0.0278 0.0364
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0623
Echinococcus granulosus UDP N acetylglucosamine dolichyl phosphate 0.0038 0.0228 0.0298
Echinococcus multilocularis a disintegrin and metalloproteinase with 0.0084 0.0758 0.0992
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0028 0.0063
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0042 0.0278 0.0623
Trichomonas vaginalis bromodomain-containing protein, putative 0.0043 0.0285 0.0531
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.0992 0.0992
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0043 0.0285 0.5946
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0028 0.0063
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0042 0.0278 0.0364
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0028 0.0063
Toxoplasma gondii aminopeptidase N, putative 0.0024 0.0071 0.1509
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0023 0.0058 0.0129
Schistosoma mansoni acetylcholine receptor subunit beta 0.0019 0.0021 0.0027
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0019 0.0021 0.0046
Onchocerca volvulus 0.0042 0.0278 0.0506
Echinococcus multilocularis peregrin 0.0032 0.0163 0.0213
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0038 0.0228 0.7074
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0014 0.0031
Schistosoma mansoni laminin gamma-3 chain 0.0028 0.0119 0.0155
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0122 0.2605
Echinococcus granulosus glycine receptor subunit beta 0.0042 0.0278 0.0364
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0623
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0028 0.0037
Schistosoma mansoni nAChR subunit 0.0042 0.0278 0.0364
Brugia malayi jmjC domain containing protein 0.0093 0.0855 0.1915
Leishmania major trypanothione reductase 0.0046 0.0323 0.713
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.023 0.2414 0.3156
Entamoeba histolytica UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0038 0.0228 0.9297
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.1125 0.1125
Echinococcus granulosus adam 0.0031 0.0153 0.02
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0024 0.0071 0.1843
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0024 0.0071 0.2196
Loa Loa (eye worm) hypothetical protein 0.0049 0.0353 0.0789
Echinococcus granulosus peregrin 0.0032 0.0163 0.0213
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0046
Brugia malayi steroid hormone receptor 0.002 0.0028 0.0063
Schistosoma mansoni microtubule-associated protein tau 0.069 0.7649 1
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0323 0.0722
Trypanosoma brucei aminopeptidase, putative 0.0024 0.0071 0.2196
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.047 0.0614
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0042 0.0278 0.0623
Loa Loa (eye worm) hypothetical protein 0.0018 0.0002 0.0005
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0042 0.0278 0.0364
Echinococcus multilocularis aminopeptidase N 0.0024 0.0071 0.0093
Brugia malayi Peptidase family M1 containing protein 0.0024 0.0071 0.0159
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0028 0.0063
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0043 0.0285 0.6067
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0028 0.0037
Brugia malayi excitatory GABA receptor EXP-1A 0.0042 0.0278 0.0623
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0038 0.0228 0.0298
Schistosoma mansoni nAChR subunit 0.0042 0.0278 0.0364
Loa Loa (eye worm) abnormal epIthelia family member 0.0028 0.0119 0.0266
Echinococcus multilocularis adam 0.0031 0.0153 0.02
Schistosoma mansoni acetylcholine receptor-related 0.0019 0.0021 0.0027
Echinococcus granulosus PHD finger protein rhinoceros 0.0028 0.0122 0.016
Schistosoma mansoni dihydroceramide desaturase 0.0018 0.0002 0.0003
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0057 0.0453 0.0592
Brugia malayi nuclear receptor NHR-88 0.002 0.0028 0.0063
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0024 0.0071 0.0093
Echinococcus granulosus neurogenic locus notch protein 0.0028 0.0119 0.0155
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0063
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.047 1
Echinococcus multilocularis ephrin type A receptor 4 A 0.0063 0.0514 0.0671
Schistosoma mansoni coup transcription factor 0.002 0.0028 0.0037
Echinococcus multilocularis lysine specific demethylase 5A 0.0034 0.019 0.0249
Plasmodium falciparum glutathione reductase 0.0046 0.0323 1
Giardia lamblia PHD finger protein 15 0.0028 0.0122 0.4699
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0028 0.0063
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0071 0.1566
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0028 0.0037
Loa Loa (eye worm) aminopeptidase N 0.0024 0.0071 0.0159
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0018 0.0002 0.0003
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0057 0.0453 1
Loa Loa (eye worm) peptidase family M1 containing protein 0.0024 0.0071 0.0159
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0014 0.0309
Brugia malayi TATA binding protein associated factor 0.0024 0.0071 0.0159
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0042 0.0278 0.0364
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0063
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0028 0.0063
Loa Loa (eye worm) hypothetical protein 0.0023 0.0058 0.0129
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0028 0.0063
Schistosoma mansoni thyroid hormone receptor 0.002 0.0028 0.0037
Mycobacterium tuberculosis Probable reductase 0.0105 0.0992 0.0992
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0071 0.0093
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0028 0.0063
Loa Loa (eye worm) jmjC domain-containing protein 0.0058 0.0465 0.1042
Trypanosoma brucei Aminopeptidase M1, putative 0.0024 0.0071 0.2196
Brugia malayi Cytochrome P450 family protein 0.0035 0.0196 0.0439
Mycobacterium ulcerans aminopeptidase N PepN 0.0024 0.0071 0.0071
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0019 0.0021 0.0046
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0043 0.0285 0.0531
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0042 0.0278 0.0364
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0453 0.0592
Plasmodium vivax hypothetical protein, conserved 0.0028 0.0122 0.2378
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0042 0.0278 0.0364
Onchocerca volvulus 0.0024 0.0071 0.0099
Plasmodium vivax N-acetylglucosamine-1-phosphate transferase, putative 0.0038 0.0228 0.4704
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0024 0.0071 0.1843
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0445 0.0582
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0028 0.0063
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0046
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.1125 0.1125
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0093 0.0855 0.1118
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0623
Entamoeba histolytica hypothetical protein 0.0023 0.0058 0.1897
Giardia lamblia UDP-N-acetylglucosamine-dolichyl-phosphateN-acetylglucosaminephosphotransferase 0.0038 0.0228 0.9297
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0042 0.0278 0.0364
Schistosoma mansoni ADAM17 peptidase (M12 family) 0.0178 0.183 0.2392
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0323 0.0422
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0028 0.0037
Loa Loa (eye worm) hypothetical protein 0.0023 0.0058 0.0129
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0623
Brugia malayi Pre-SET motif family protein 0.0059 0.047 0.1051
Echinococcus multilocularis microtubule associated protein 2 0.069 0.7649 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0623
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0028 0.0037
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0019 0.0021 0.0046
Schistosoma mansoni nAChR subunit 0.0042 0.0278 0.0364
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0042 0.0278 0.0364
Brugia malayi Cytochrome P450 family protein 0.0035 0.0196 0.0439
Loa Loa (eye worm) hypothetical protein 0.0023 0.0058 0.0129
Onchocerca volvulus Putative nachr subunit 0.0042 0.0278 0.0506
Echinococcus multilocularis leukotriene A 4 hydrolase 0.023 0.2414 0.3156
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0063
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0042 0.0278 0.0623
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0028 0.0063
Trypanosoma cruzi aminopeptidase, putative 0.0024 0.0071 0.2196
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0042 0.0278 0.0623
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0623
Brugia malayi Peptidase family M1 containing protein 0.0024 0.0071 0.0159
Brugia malayi hypothetical protein 0.0024 0.0071 0.0159
Loa Loa (eye worm) hypothetical protein 0.0059 0.047 0.1051
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0323 0.6776
Schistosoma mansoni nAChR subunit 0.0019 0.0021 0.0027
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0063
Echinococcus granulosus a disintegrin and metalloproteinase with 0.0084 0.0758 0.0992
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0042 0.0278 0.0623
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0024 0.0071 0.1249
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0145 0.1449 0.1894
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0024 0.0071 0.2196
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0042 0.0278 0.0364
Brugia malayi metalloprotease disintegrin 16 with thrombospondin type I motif 0.0084 0.0758 0.1698
Brugia malayi Cytochrome P450 family protein 0.0037 0.0217 0.0486
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0042 0.0278 0.0623
Loa Loa (eye worm) glutathione reductase 0.0046 0.0323 0.0722
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0063
Brugia malayi laminin-like protein K08C7.3 precursor 0.0028 0.0119 0.0266
Brugia malayi nuclear hormone receptor 0.002 0.0028 0.0063
Loa Loa (eye worm) acetylcholine receptor protein 0.0019 0.0021 0.0046
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0623
Trypanosoma cruzi cytochrome P450, putative 0.0035 0.0196 0.6073
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0623
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.1125 0.1125
Brugia malayi Thioredoxin reductase 0.0046 0.0323 0.0722
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0042 0.0278 0.0364
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0071 0.1566
Echinococcus granulosus glycine receptor subunit alpha 1 0.0042 0.0278 0.0364
Onchocerca volvulus 0.0023 0.0058 0.0073
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0042 0.0278 0.0364
Echinococcus granulosus slit 2 protein 0.0028 0.0119 0.0155
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0071 0.0093
Schistosoma mansoni jumonji/arid domain-containing protein 0.0034 0.019 0.0249
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0024 0.0071 0.0112
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0046
Brugia malayi hypothetical protein 0.0019 0.0021 0.0046
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0014 0.0018
Brugia malayi hypothetical protein 0.0019 0.0021 0.0046
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0071 0.1566
Echinococcus granulosus glycine receptor subunit beta 0.0042 0.0278 0.0364
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0046
Echinococcus granulosus lysine specific demethylase 5A 0.0034 0.019 0.0249
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0028 0.0063
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0028 0.0037
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0071 0.1566
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0028 0.0063
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0028 0.0037
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0043 0.0285 0.6067
Echinococcus granulosus FTZ F1 alpha 0.002 0.0028 0.0037
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0057 0.0453 0.0453
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0071 0.0093
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0019 0.0021 0.0027
Echinococcus multilocularis glycine receptor subunit beta 0.0042 0.0278 0.0364
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0028 0.0122 0.016
Plasmodium falciparum phd finger protein, putative 0.0028 0.0122 0.3509
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0046
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0244 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0623
Echinococcus multilocularis slit 2 protein 0.0028 0.0119 0.0155
Schistosoma mansoni ap endonuclease 0.0019 0.0014 0.0018
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0024 0.0071 0.1249
Loa Loa (eye worm) hypothetical protein 0.0032 0.0159 0.0356
Plasmodium falciparum UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0038 0.0228 0.6941
Echinococcus granulosus nAChR subunit 0.0042 0.0278 0.0364
Loa Loa (eye worm) jmjC domain-containing protein 0.0034 0.019 0.0426
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0028 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0028 0.0063
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0057 0.0453 0.0453
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0028 0.0063
Loa Loa (eye worm) hypothetical protein 0.0375 0.4065 0.9099
Echinococcus granulosus pikachurin 0.0028 0.0119 0.0155
Trichomonas vaginalis glucosaminephosphotransferase, putative 0.0038 0.0228 0.042
Echinococcus granulosus Blood coagulation inhibitor Disintegrin 0.0112 0.1074 0.1404
Echinococcus multilocularis Blood coagulation inhibitor, Disintegrin 0.0112 0.1074 0.1404
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0042 0.0278 0.0364
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0019 0.0021 0.0046
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0028 0.0037
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0042 0.0278 0.0364
Loa Loa (eye worm) hypothetical protein 0.0024 0.0071 0.0159
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0046
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0623
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0042 0.0278 0.0623
Schistosoma mansoni subfamily M12B unassigned peptidase (M12 family) 0.0018 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0023 0.0058 0.0129
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.1402 0.1833
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0042 0.0278 0.0623
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0021 0.0046
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0019 0.0021 0.0046
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0028 0.0037
Loa Loa (eye worm) reprolysin 0.0018 0.0002 0.0005
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0019 0.0021 0.0027
Echinococcus multilocularis jumonji domain containing protein 0.0039 0.0249 0.0325
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0028 0.0037
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0323 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0058 0.0129
Brugia malayi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0038 0.0228 0.0511
Onchocerca volvulus 0.0038 0.0228 0.0408
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.0992 0.0992
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.0992 0.0992
Plasmodium falciparum thioredoxin reductase 0.0046 0.0323 1
Toxoplasma gondii exonuclease III APE 0.0019 0.0014 0.0298
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0623
Toxoplasma gondii aminopeptidase N protein 0.0024 0.0071 0.1509
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0057 0.0453 0.1013
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0071 0.0093
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0057 0.0453 0.0592
Onchocerca volvulus 0.0042 0.0278 0.0506
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0042 0.0278 0.0623
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0623
Leishmania major cytochrome p450-like protein 0.0035 0.0196 0.433
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.0058 0.0129
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0014 0.0434
Schistosoma mansoni neurotransmitter gated ion channel 0.0023 0.0058 0.0075
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0028 0.0063
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.041 0.4468 1
Onchocerca volvulus 0.0042 0.0278 0.0506
Toxoplasma gondii glycosyl transferase, group 4 family protein 0.0038 0.0228 0.4862
Mycobacterium ulcerans aminopeptidase N PepN 0.0024 0.0071 0.0071
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0024 0.0071 0.2196
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0014 0.0434
Echinococcus multilocularis PHD finger protein rhinoceros 0.0028 0.0122 0.016
Loa Loa (eye worm) ACC-1 protein 0.0042 0.0278 0.0623
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0071 0.0093
Echinococcus multilocularis adam 17 protease 0.0178 0.183 0.2392
Echinococcus granulosus nAChR subunit 0.0023 0.0058 0.0075
Onchocerca volvulus 0.0042 0.0278 0.0506
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0323 0.0422
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0623
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0145 0.1449 0.1894
Trypanosoma brucei trypanothione reductase 0.0046 0.0323 1
Echinococcus multilocularis UDP N acetylglucosamine dolichyl phosphate 0.0038 0.0228 0.0298
Schistosoma mansoni hypothetical protein 0.0028 0.0122 0.016
Loa Loa (eye worm) cytochrome P450 family protein 0.0035 0.0196 0.0439
Loa Loa (eye worm) LGC-31 protein 0.0042 0.0278 0.0623
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0042 0.0278 0.0623
Brugia malayi acetyltransferase, GNAT family protein 0.0145 0.1449 0.3243
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0042 0.0278 0.0623
Brugia malayi Disintegrin family protein 0.0018 0.0002 0.0005
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.047 0.0614
Onchocerca volvulus 0.0062 0.0506 0.0953
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0042 0.0278 0.0364
Brugia malayi Bromodomain containing protein 0.0032 0.0163 0.0364
Schistosoma mansoni cell polarity protein 0.0028 0.0119 0.0155
Schistosoma mansoni nAChR subunit 0.0042 0.0278 0.0364
Loa Loa (eye worm) hypothetical protein 0.0062 0.0506 0.1132
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0024 0.0071 0.0093
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0028 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0028 0.0063
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0024 0.0071 0.2196
Loa Loa (eye worm) ACC-1 protein 0.0042 0.0278 0.0623
Wolbachia endosymbiont of Brugia malayi phospho-N-acetylmuramoyl-pentapeptide-transferase 0.0896 1 1
Trypanosoma brucei UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0038 0.0228 0.7074
Trypanosoma cruzi Aminopeptidase M1, putative 0.0024 0.0071 0.2196
Brugia malayi hypothetical protein 0.0031 0.0153 0.0342
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0063
Brugia malayi Thrombospondin N-terminal -like domain containing protein 0.0028 0.0119 0.0266
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0046
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0023 0.0058 0.0129
Plasmodium vivax SET domain protein, putative 0.0059 0.047 1
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.0992 0.0992
Mycobacterium ulcerans undecapaprenyl-phosphate alpha-N-acetylglucosaminyltransferase Rfe 0.0038 0.0228 0.0228
Loa Loa (eye worm) leukotriene A4 hydrolase 0.023 0.2414 0.5404
Schistosoma mansoni nAChR subunit 0.0042 0.0278 0.0364
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0028 0.0063
Loa Loa (eye worm) hypothetical protein 0.0023 0.0058 0.0129
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0014 0.0434
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0028 0.0063
Echinococcus multilocularis subfamily M12B unassigned peptidase 0.0018 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0623
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0014 0.0014
Schistosoma mansoni slit 0.0028 0.0119 0.0155
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.047 0.0614
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0042 0.0278 0.0623
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0046
Echinococcus multilocularis neurogenic locus notch protein 0.0028 0.0119 0.0155
Trichomonas vaginalis set domain proteins, putative 0.0467 0.5112 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0028 0.0063
Loa Loa (eye worm) hypothetical protein 0.0028 0.0119 0.0266
Loa Loa (eye worm) GABA receptor subunit 0.0023 0.0058 0.0129
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0028 0.0037
Mycobacterium tuberculosis Probable phospho-N-acetylmuramoyl-pentappeptidetransferase MurX 0.0896 1 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0028 0.0037
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0021 0.0046
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0028 0.0037
Trypanosoma cruzi UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase, putative 0.0038 0.0228 0.7074
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0046
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0623
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0028 0.0015
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0019 0.0021 0.0027
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0024 0.0071 0.2196
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.0992 0.0992
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0042 0.0278 0.0623
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0042 0.0278 0.0364
Schistosoma mansoni UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase 0.0038 0.0228 0.0298
Schistosoma mansoni adam (A disintegrin and metalloprotease 0.0031 0.0153 0.02
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0071 0.0093
Brugia malayi laminin alpha chain 0.0028 0.0119 0.0266
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.047 0.0614
Schistosoma mansoni neurotransmitter gated ion channel 0.0019 0.0021 0.0027
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0053 0.0409 0.0915
Brugia malayi Cation transporter family protein 0.0042 0.0278 0.0623
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0042 0.0278 0.0623
Echinococcus granulosus microtubule associated protein 2 0.069 0.7649 1
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0042 0.0278 0.0364
Loa Loa (eye worm) hypothetical protein 0.0042 0.0278 0.0623
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0042 0.0278 0.0623
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0028 0.0037
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0023 0.0058 0.0075
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0244 0.7467
Onchocerca volvulus 0.0024 0.0071 0.0099
Toxoplasma gondii thioredoxin reductase 0.0046 0.0323 0.6873
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.047 0.0614
Brugia malayi EGF-like domain containing protein 0.0028 0.0119 0.0266
Schistosoma mansoni ADAMTS5 peptidase (M12 family) 0.0084 0.0758 0.0992
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0042 0.0278 0.0623
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0028 0.0063
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0021 0.0046
Loa Loa (eye worm) hypothetical protein 0.0019 0.0021 0.0046
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0028 0.0037
Loa Loa (eye worm) hypothetical protein 0.0028 0.0119 0.0266
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0028 0.0063
Loa Loa (eye worm) acetyltransferase 0.0145 0.1449 0.3243
Schistosoma mansoni jumonji domain containing protein 0.0074 0.0639 0.0835
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0042 0.0278 0.0364
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0042 0.0278 0.0364
Toxoplasma gondii PHD-finger domain-containing protein 0.0028 0.0122 0.2605
Onchocerca volvulus Alhambra homolog 0.0028 0.0122 0.02

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 2500 ng ml-1 Inhibitory activity against translocase I ChEMBL. 14611838
IC50 (binding) > 2500 ng ml-1 Inhibitory activity against translocase I ChEMBL. 14611838
MIC (functional) > 50 ug ml-1 Antimycobacterial activity against Mycobacterium smegmatis (SANK 75075) ChEMBL. 14611838

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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