Detailed information for compound 1612148

Basic information

Technical information
  • TDR Targets ID: 1612148
  • Name: AIDS160410
  • MW: 357.425 | Formula: C22H15NO2S
  • H donors: 0 H acceptors: 2 LogP: 3.58 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1N(c2ccccc2)C(=O)C2C1C1SC2c2c1cc1c(c2)cccc1
  • InChi: 1S/C22H15NO2S/c24-21-17-18(22(25)23(21)14-8-2-1-3-9-14)20-16-11-13-7-5-4-6-12(13)10-15(16)19(17)26-20/h1-11,17-20H
  • InChiKey: FKHRJQRQRDBPQA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4,11-Epithio-1H-naphth[2,3-f]isoindole-1,3(2H)-dione, 3a,4,11,11a-tetrahydro-2-phenyl-
  • NCI60_008819
  • NSC627597
  • AIDS-160410

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Echinococcus granulosus expressed conserved protein 0.0215 0.2548 0.2544
Trichomonas vaginalis AGC family protein kinase 0.0147 0.1676 0.555
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.2022 0.6707
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0266 0.3322
Loa Loa (eye worm) hypothetical protein 0.0105 0.1144 0.2582
Schistosoma mansoni tyrosine protein kinase 0.0147 0.1676 0.1676
Echinococcus granulosus expressed protein 0.0016 0.0021 0.0014
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.1676 0.34
Echinococcus granulosus neuropeptide s receptor 0.0449 0.5518 0.5516
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0147 0.1676 0.1671
Echinococcus multilocularis tyrosine protein kinase Blk 0.0362 0.4412 0.4409
Schistosoma mansoni tyrosine kinase 0.0362 0.4412 0.4412
Schistosoma mansoni tyrosine kinase 0.0147 0.1676 0.1676
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0105 0.114 0.1364
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Echinococcus granulosus tyrosine protein kinase 0.0147 0.1676 0.1671
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0215 0.2548 0.2548
Loa Loa (eye worm) TK protein kinase 0.0362 0.4412 1
Echinococcus multilocularis chromobox protein 1 0.0068 0.067 0.0664
Loa Loa (eye worm) TK/FER protein kinase 0.0147 0.1676 0.379
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0266 0.1588
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0394 0.0388
Brugia malayi Variant SH3 domain containing protein 0.0215 0.2548 0.5769
Loa Loa (eye worm) hypothetical protein 0.0147 0.1676 0.379
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.1289 0.1542
Echinococcus multilocularis tyrosine protein kinase csk 0.0147 0.1676 0.1671
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0014 0.0081
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0252 0.3009 0.6814
Loa Loa (eye worm) hypothetical protein 0.0215 0.2548 0.5769
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0774 1
Loa Loa (eye worm) hypothetical protein 0.0362 0.4412 1
Schistosoma mansoni bromodomain containing protein 0.0061 0.059 0.059
Schistosoma mansoni microtubule-associated protein tau 0.0802 1 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.1676 0.379
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0215 0.2548 0.2544
Echinococcus multilocularis neuropeptide s receptor 0.0449 0.5518 0.5516
Brugia malayi glutathione reductase 0.0046 0.0394 0.0881
Echinococcus multilocularis protein kinase 0.0147 0.1676 0.1671
Trichomonas vaginalis serine/threonine-protein kinase wnk, putative 0.0147 0.1676 0.555
Echinococcus multilocularis SH2 domain containing protein 7 0.0215 0.2548 0.2544
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0397 0.2971
Schistosoma mansoni protein kinase 0.0147 0.1676 0.1676
Echinococcus multilocularis macrophage colony stimulating factor 1 receptor 0.0147 0.1676 0.1671
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0362 0.4412 0.4409
Trypanosoma cruzi trypanothione reductase, putative 0.0016 0.0014 0.0081
Echinococcus granulosus atrial natriuretic peptide receptor 1 0.0147 0.1676 0.1671
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0442 0.0525
Loa Loa (eye worm) TK protein kinase 0.0147 0.1676 0.379
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Entamoeba histolytica protein kinase, putative 0.0215 0.2548 0.5504
Mycobacterium tuberculosis Conserved protein 0.0105 0.1144 0.1368
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0147 0.1676 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0147 0.1676 0.1671
Brugia malayi Bromodomain containing protein 0.0073 0.0734 0.1653
Onchocerca volvulus 0.0046 0.0397 0.0493
Entamoeba histolytica cysteine surface protein, putative 0.0147 0.1676 0.34
Echinococcus granulosus retinal guanylyl cyclase 2 0.0147 0.1676 0.1671
Trichomonas vaginalis conserved hypothetical protein 0.0147 0.1676 0.555
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0147 0.1676 0.379
Schistosoma mansoni protein kinase 0.0147 0.1676 0.1676
Toxoplasma gondii ABC1 family protein 0.0105 0.1144 0.6814
Brugia malayi Inositol-1 0.0036 0.0266 0.059
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.379
Echinococcus multilocularis tyrosine kinase 0.0147 0.1676 0.1671
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0014 0.0081
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0774 1
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.1676 0.34
Mycobacterium ulcerans beta-lactamase 0.0105 0.1144 1
Schistosoma mansoni ephrin receptor 0.0147 0.1676 0.1676
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0147 0.1676 0.34
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Echinococcus granulosus retinal guanylyl cyclase 2 0.0147 0.1676 0.1671
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Brugia malayi hypothetical protein 0.0362 0.4412 1
Onchocerca volvulus 0.0147 0.1676 0.3521
Mycobacterium tuberculosis Conserved protein 0.0105 0.1144 0.1368
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0105 0.114 0.1364
Echinococcus multilocularis tyrosine protein kinase Fes:Fps 0.0147 0.1676 0.1671
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0147 0.1676 0.34
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0362 0.4412 0.4409
Echinococcus granulosus tyrosine protein kinase Blk 0.0362 0.4412 0.4409
Schistosoma mansoni tyrosine kinase 0.0147 0.1676 0.1676
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0014 0.0081
Brugia malayi Variant SH3 domain containing protein 0.0215 0.2548 0.5769
Loa Loa (eye worm) protein kinase domain-containing protein 0.0147 0.1676 0.379
Schistosoma mansoni protein kinase 0.0147 0.1676 0.1676
Loa Loa (eye worm) hypothetical protein 0.0034 0.0249 0.0552
Onchocerca volvulus Suppressor of cytokine signaling at 36E homolog 0.0215 0.2548 0.5586
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Onchocerca volvulus 0.0147 0.1676 0.3521
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0016 0.0021 0.0017
Entamoeba histolytica tyrosin kinase, putative 0.0147 0.1676 0.34
Schistosoma mansoni tyrosine kinase 0.0147 0.1676 0.1676
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1909 0.633
Entamoeba histolytica hypothetical protein, conserved 0.0147 0.1676 0.34
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0362 0.4412 0.4409
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0215 0.2548 0.2544
Brugia malayi integrin-linked kinase 0.0147 0.1676 0.379
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0215 0.2548 0.2548
Loa Loa (eye worm) hypothetical protein 0.0215 0.2548 0.5769
Loa Loa (eye worm) hypothetical protein 0.0017 0.0022 0.0035
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0147 0.1676 0.1671
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0026 0.0143 0.0968
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0254 0.0248
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0147 0.1676 0.379
Echinococcus granulosus N chimaerin 0.0215 0.2548 0.2544
Entamoeba histolytica tyrosine kinase, putative 0.0147 0.1676 0.34
Schistosoma mansoni GTPase activating protein 0.0215 0.2548 0.2548
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.379
Loa Loa (eye worm) SRC-1 0.0362 0.4412 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0774 0.1742
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Loa Loa (eye worm) hypothetical protein 0.0034 0.0249 0.0552
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0774 0.4598
Entamoeba histolytica leucine-rich repeat domain-containing protein 0.0147 0.1678 0.3404
Schistosoma mansoni hypothetical protein 0.0164 0.1896 0.1896
Mycobacterium tuberculosis Probable dehydrogenase 0.0105 0.114 0.1364
Brugia malayi Variant SH3 domain containing protein 0.0215 0.2548 0.5769
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0215 0.2548 0.5769
Mycobacterium ulcerans hypothetical protein 0.0046 0.0397 0.3395
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0215 0.2548 0.5769
Entamoeba histolytica tyrosine kinase, putative 0.0147 0.1676 0.34
Plasmodium falciparum thioredoxin reductase 0.0016 0.0014 0.0045
Echinococcus multilocularis transfer RNA-Thr 0.0147 0.1676 0.1671
Echinococcus granulosus receptor type guanylyl cyclase 0.0147 0.1676 0.1671
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0394 0.2324
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.379
Brugia malayi Probable tyrosine-protein kinase kin-31 0.0147 0.1676 0.379
Loa Loa (eye worm) TK/DDR protein kinase 0.0147 0.1676 0.379
Brugia malayi Tyrosine-protein kinase F09A5.2 in chromosome X, putative 0.0147 0.1676 0.379
Trichomonas vaginalis protein tyrosine kinase, putative 0.0147 0.1676 0.555
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0147 0.1676 0.34
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0774 0.6726
Schistosoma mansoni tyrosine kinase 0.0147 0.1676 0.1676
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0362 0.4412 0.4409
Brugia malayi Thioredoxin reductase 0.0046 0.0394 0.0881
Schistosoma mansoni chromobox protein 0.0068 0.067 0.067
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0266 0.0843
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0266 0.1588
Onchocerca volvulus Huntingtin homolog 0.0119 0.1321 0.268
Onchocerca volvulus Tyrosine kinase receptor Cad96Ca homolog 0.0147 0.1676 0.3521
Loa Loa (eye worm) TK/CSK protein kinase 0.0147 0.1676 0.379
Brugia malayi ephrin receptor 1 precursor 0.0147 0.1676 0.379
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Entamoeba histolytica protein kinase, putative 0.0147 0.1676 0.34
Loa Loa (eye worm) TKL/MLK/ILK protein kinase 0.0147 0.1676 0.379
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0397 0.2371
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0362 0.4412 0.4409
Echinococcus granulosus c src tyrosine kinase 0.0362 0.4412 0.4409
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0397 0.0888
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0147 0.1676 0.1671
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0089 0.0089
Schistosoma mansoni signal transduction protein lnk-related 0.0215 0.2548 0.2548
Brugia malayi Tyrosine-protein kinase PR2 0.0147 0.1676 0.379
Loa Loa (eye worm) hypothetical protein 0.0147 0.1676 0.379
Entamoeba histolytica protein kinase, putative 0.0147 0.1676 0.34
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Schistosoma mansoni apoferritin-2 0.0016 0.0021 0.0021
Loa Loa (eye worm) TK/INSR protein kinase 0.0147 0.1676 0.379
Loa Loa (eye worm) hypothetical protein 0.0215 0.2548 0.5769
Onchocerca volvulus Tyrosine kinase homolog 0.0147 0.1676 0.3521
Brugia malayi Raf kinase 0.0147 0.1676 0.379
Schistosoma mansoni tyrosine kinase 0.0362 0.4412 0.4412
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0397 0.2371
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0006 0.0037
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0266 0.2234
Loa Loa (eye worm) bromodomain containing protein 0.0017 0.0029 0.0052
Entamoeba histolytica tyrosine kinase, putative 0.0147 0.1676 0.34
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0774 0.6726
Schistosoma mansoni tyrosine kinase 0.0147 0.1676 0.1676
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0397 0.3395
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.379
Schistosoma mansoni tyrosine kinase 0.0362 0.4412 0.4412
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1909 0.633
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0774 0.0768
Loa Loa (eye worm) hypothetical protein 0.0041 0.0336 0.075
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0266 0.1588
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0147 0.1676 0.1671
Echinococcus granulosus tyrosine protein kinase Fes:Fps 0.0147 0.1676 0.1671
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0252 0.3009 0.6814
Mycobacterium tuberculosis Probable reductase 0.0105 0.114 0.1364
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.1676 0.1676
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0147 0.1676 0.34
Loa Loa (eye worm) TK/EGFR protein kinase 0.0147 0.1676 0.379
Trypanosoma brucei Pseudokinase, putative 0.0147 0.1676 1
Schistosoma mansoni protein kinase 0.0147 0.1676 0.1676
Brugia malayi Immunoglobulin I-set domain containing protein 0.0147 0.1676 0.379
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0147 0.1676 1
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.1676 0.34
Loa Loa (eye worm) TK/FER protein kinase 0.0147 0.1676 0.379
Loa Loa (eye worm) hypothetical protein 0.0215 0.2548 0.5769
Loa Loa (eye worm) TK/FER protein kinase 0.0147 0.1676 0.379
Schistosoma mansoni protein kinase 0.0147 0.1676 0.1676
Loa Loa (eye worm) hypothetical protein 0.0039 0.0313 0.0696
Entamoeba histolytica protein kinase, putative 0.0147 0.1676 0.34
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0046 0.0397 0.3395
Plasmodium falciparum protein kinase, putative 0.0147 0.1676 1
Onchocerca volvulus 0.0147 0.1676 0.3521
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0442 0.0437
Loa Loa (eye worm) hypothetical protein 0.0119 0.1321 0.2984
Schistosoma mansoni protein kinase 0.0147 0.1676 0.1676
Entamoeba histolytica protein kinase, putative 0.0147 0.1676 0.34
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0215 0.2548 0.2544
Echinococcus multilocularis tyrosine protein kinase 0.0147 0.1676 0.1671
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0147 0.1676 0.1676
Echinococcus multilocularis heat shock protein 70 0.0147 0.1676 0.1671
Trichomonas vaginalis ferritin, putative 0.0016 0.0021 0.0023
Schistosoma mansoni protein kinase 0.0147 0.1676 0.1676
Echinococcus multilocularis ephrin type A receptor 4 A 0.0147 0.1676 0.1671
Schistosoma mansoni ephrin receptor 0.0147 0.1676 0.1676
Brugia malayi cytokine inducible SH2-containing protein 5 0.0215 0.2548 0.5769
Onchocerca volvulus 0.0215 0.2548 0.5586
Giardia lamblia Kinase, NEK 0.0147 0.1676 1
Entamoeba histolytica hypothetical protein 0.0147 0.1676 0.34
Echinococcus granulosus tensin 0.0215 0.2548 0.2544
Schistosoma mansoni tyrosine kinase 0.0147 0.1676 0.1676
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0016 0.0014 0.0045
Echinococcus multilocularis insulin growth factor 1 receptor beta 0.0147 0.1676 0.1671
Echinococcus granulosus tyrosine kinase 0.0147 0.1676 0.1671
Echinococcus granulosus raf serine:threonine protein kinase 0.0147 0.1676 0.1671
Entamoeba histolytica tyrosine kinase, putative 0.0147 0.1676 0.34
Toxoplasma gondii STE kinase 0.0147 0.1676 1
Echinococcus granulosus zinc finger protein 0.0019 0.0053 0.0046
Plasmodium vivax tyrosine kinase-like protein, putative 0.0147 0.1676 1
Echinococcus multilocularis tyrosine protein kinase csk 0.0147 0.1676 0.1671
Schistosoma mansoni protein tyrosine phosphatase n11 (shp2) 0.0215 0.2548 0.2548
Onchocerca volvulus 0.0362 0.4412 1
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.379
Loa Loa (eye worm) TK/ROR protein kinase 0.0147 0.1676 0.379
Echinococcus granulosus SH2 domain containing adapter protein F 0.0215 0.2548 0.2544
Schistosoma mansoni tyrosine kinase 0.0147 0.1676 0.1676
Loa Loa (eye worm) TKL/RAF/RAF protein kinase 0.0147 0.1676 0.379
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0105 0.1144 0.2582
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.1676 0.34
Onchocerca volvulus 0.0362 0.4412 1
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Trichomonas vaginalis conserved hypothetical protein 0.0147 0.1676 0.555
Onchocerca volvulus 0.0362 0.4412 1
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0105 0.114 0.1364
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0266 0.1588
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0016 0.0021 0.0091
Brugia malayi hypothetical protein 0.0147 0.1676 0.379
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.3009 1
Echinococcus granulosus signal transduction protein lnk realted 0.0215 0.2548 0.2544
Brugia malayi Tensin 0.0215 0.2548 0.5769
Trichomonas vaginalis D-aminoacylase, putative 0.0105 0.1144 0.3774
Echinococcus multilocularis geminin 0.0164 0.1896 0.1891
Trichomonas vaginalis STE family protein kinase 0.0147 0.1676 0.555
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Echinococcus multilocularis SH2 domain containing adapter protein F 0.0215 0.2548 0.2544
Loa Loa (eye worm) TK protein kinase 0.0147 0.1676 0.379
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.3009 1
Loa Loa (eye worm) TK/FER protein kinase 0.0362 0.4412 1
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0215 0.2548 0.2544
Echinococcus granulosus histone lysine methyltransferase setb 0.0017 0.0022 0.0015
Entamoeba histolytica protein kinase, putative 0.0147 0.1676 0.34
Echinococcus multilocularis fibroblast growth factor receptor 4 0.0147 0.1676 0.1671
Schistosoma mansoni suppressor of cytokine signaling 0.0215 0.2548 0.2548
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0147 0.1676 0.1671
Echinococcus multilocularis protein kinase 0.0147 0.1676 0.1671
Loa Loa (eye worm) RGC/RGC protein kinase 0.0147 0.1676 0.379
Echinococcus granulosus tyrosine protein kinase transmembrane receptor 0.0147 0.1676 0.1671
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Echinococcus multilocularis receptor type guanylyl cyclase 0.0147 0.1676 0.1671
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0215 0.2548 0.2544
Schistosoma mansoni tyrosine kinase 0.0362 0.4412 0.4412
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0014 0.0081
Brugia malayi beta-lactamase family protein 0.0105 0.1144 0.2582
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.3009 1
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0066 0.0135
Echinococcus multilocularis signal transduction protein lnk realted 0.0215 0.2548 0.2544
Trypanosoma brucei AGC/RSK family serine/threonine kinase, putative 0.0147 0.1676 1
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0774 0.594
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0397 0.0316
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.1144 0.6826
Loa Loa (eye worm) hypothetical protein 0.0105 0.1144 0.2582
Trypanosoma cruzi protein kinase, putative 0.0147 0.1676 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.1144 0.2582
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0147 0.1676 0.379
Echinococcus multilocularis suppressor of cytokine signaling 6 0.0215 0.2548 0.2544
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0147 0.1676 0.379
Plasmodium vivax acyl-CoA synthetase, putative 0.0034 0.0249 0.1456
Loa Loa (eye worm) hypothetical protein 0.0119 0.1321 0.2984
Onchocerca volvulus 0.0362 0.4412 1
Echinococcus multilocularis NCK adaptor protein 0.0215 0.2548 0.2544
Brugia malayi hypothetical protein 0.0215 0.2548 0.5769
Echinococcus granulosus activated cdc42 kinase 1 0.0147 0.1676 0.1671
Plasmodium falciparum thioredoxin reductase 0.0046 0.0394 0.2324
Toxoplasma gondii Tyrosine kinase-like (TKL) protein 0.0147 0.1676 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0266 0.0843
Entamoeba histolytica protein kinase, putative 0.0147 0.1676 0.34
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.379
Entamoeba histolytica protein kinase, putative 0.0147 0.1676 0.34
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1909 0.633
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0143 0.0821
Brugia malayi Protein kinase domain containing protein 0.0362 0.4412 1
Trichomonas vaginalis TK family protein kinase 0.0147 0.1676 0.555
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0046 0.0397 0.047
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0219 0.0255
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1909 0.633
Echinococcus granulosus SH2 domain containing protein 7 0.0215 0.2548 0.2544
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.1676 0.1676
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0016 0.0014 0.0009
Onchocerca volvulus 0.0147 0.1676 0.3521
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.379
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0147 0.1676 0.1676
Schistosoma mansoni tensin 0.0215 0.2548 0.2548
Echinococcus granulosus tyrosine protein kinase Srms 0.0362 0.4412 0.4409
Schistosoma mansoni tyrosine kinase 0.0362 0.4412 0.4412
Echinococcus multilocularis protein KINase family member (kin 25) 0.0147 0.1676 0.1671
Echinococcus multilocularis chromobox protein 1 0.0068 0.067 0.0664
Loa Loa (eye worm) hypothetical protein 0.0215 0.2548 0.5769
Brugia malayi SH2 domain containing protein 0.0215 0.2548 0.5769
Schistosoma mansoni protein kinase 0.0147 0.1676 0.1676
Onchocerca volvulus 0.0147 0.1676 0.3521
Loa Loa (eye worm) TKL/MLK/HH498 protein kinase 0.0147 0.1676 0.379
Echinococcus granulosus basic fibroblast growth factor receptor 1 A 0.0147 0.1676 0.1671
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.379
Onchocerca volvulus Glucosylceramidase homolog 0.0165 0.1909 0.4074
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0266 0.1557
Echinococcus granulosus protein kinase 0.0147 0.1676 0.1671
Loa Loa (eye worm) hypothetical protein 0.0034 0.0249 0.0552
Schistosoma mansoni hypothetical protein 0.0215 0.2548 0.2548
Loa Loa (eye worm) hypothetical protein 0.0034 0.0249 0.0552
Mycobacterium leprae Probable lipase LipE 0.0105 0.1144 0.8858
Schistosoma mansoni chromobox protein 0.0068 0.067 0.067
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Entamoeba histolytica tyrosine kinase, putative 0.0147 0.1676 0.34
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0014 0.0081
Entamoeba histolytica serine/threonine kinase, putative 0.0147 0.1676 0.34
Brugia malayi Tyrosine-protein kinase abl-1 0.0362 0.4412 1
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.379
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0016 0.0014 0.0045
Trypanosoma cruzi protein kinase, putative 0.0147 0.1676 1
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0014 0.0045
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0147 0.1676 0.379
Entamoeba histolytica protein kinase, putative 0.0147 0.1676 0.34
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Schistosoma mansoni adapter molecule crk 0.0215 0.2548 0.2548
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0014 0.0014
Echinococcus granulosus geminin 0.0164 0.1896 0.1891
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.1676 0.1676
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Loa Loa (eye worm) TK/FER protein kinase 0.0362 0.4412 1
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0014 0.0045
Echinococcus multilocularis beta LACTamase domain containing family member 0.0105 0.1144 0.1138
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.379
Echinococcus granulosus protein tyrosine kinase 0.0147 0.1676 0.1671
Loa Loa (eye worm) hypothetical protein 0.003 0.0189 0.0415
Loa Loa (eye worm) hypothetical protein 0.0215 0.2548 0.5769
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.1676 0.34
Loa Loa (eye worm) hypothetical protein 0.0046 0.0397 0.0888
Echinococcus multilocularis FL cytokine receptor 0.0147 0.1676 0.1671
Schistosoma mansoni tyrosine protein kinase fes (fps) (ptk group IV) 0.0147 0.1676 0.1676
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0105 0.114 0.8831
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.379
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0046 0.0397 0.3395
Echinococcus multilocularis tyrosine protein kinase csk 0.0147 0.1676 0.1671
Schistosoma mansoni tyrosine-protein kinase fps85d 0.0147 0.1676 0.1676
Schistosoma mansoni tyrosine kinase 0.0147 0.1676 0.1676
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0026 0.0143 0.0821
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0014 0.0081
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.1676 0.34
Brugia malayi Heterochromatin protein 1 0.0068 0.067 0.1507
Trichomonas vaginalis glucosylceramidase, putative 0.0174 0.2022 0.6707
Echinococcus multilocularis activin receptor type 0.0147 0.1676 0.1671
Onchocerca volvulus 0.0215 0.2548 0.5586
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Entamoeba histolytica protein kinase, putative 0.0147 0.1676 0.34
Loa Loa (eye worm) inositol-1 0.0036 0.0266 0.059
Loa Loa (eye worm) hypothetical protein 0.0046 0.0397 0.0888
Leishmania major protein kinase, putative 0.0147 0.1676 1
Loa Loa (eye worm) TK/FER protein kinase 0.0362 0.4412 1
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0016 0.0014 0.0081
Plasmodium falciparum tyrosine kinase-like protein 0.0147 0.1676 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0046 0.0397 0.2971
Loa Loa (eye worm) hypothetical protein 0.0215 0.2548 0.5769
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0362 0.4412 0.4409
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.1676 0.34
Trichomonas vaginalis conserved hypothetical protein 0.0147 0.1676 0.555
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Entamoeba histolytica hypothetical protein 0.0147 0.1676 0.34
Loa Loa (eye worm) TK/FER protein kinase 0.0147 0.1676 0.379
Loa Loa (eye worm) hypothetical protein 0.0215 0.2548 0.5769
Plasmodium falciparum acyl-CoA synthetase 0.0034 0.0249 0.1456
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.1289 0.1542
Schistosoma mansoni hypothetical protein 0.002 0.0066 0.0066
Onchocerca volvulus 0.0215 0.2548 0.5586
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0089 0.0083
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0215 0.2548 0.5769
Loa Loa (eye worm) hypothetical protein 0.0215 0.2548 0.5769
Echinococcus granulosus tyrosine protein kinase HCK 0.0147 0.1676 0.1671
Entamoeba histolytica tyrosine- protein kinase 2, putative 0.0147 0.1676 0.34
Echinococcus granulosus beta LACTamase domain containing family member 0.0105 0.1144 0.1138
Trichomonas vaginalis D-aminoacylase, putative 0.0105 0.1144 0.3774
Entamoeba histolytica hypothetical protein 0.0147 0.1676 0.34
Schistosoma mansoni growth factor receptor-bound protein 0.0215 0.2548 0.2548
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0016 0.0014 0.0081
Echinococcus granulosus ferritin 0.0016 0.0021 0.0014
Loa Loa (eye worm) TK/FER protein kinase 0.0362 0.4412 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0034 0.0249 0.0292
Schistosoma mansoni protein kinase 0.0147 0.1676 0.1676
Loa Loa (eye worm) glutathione reductase 0.0046 0.0394 0.0881
Echinococcus granulosus epidermal growth factor receptor 0.0147 0.1676 0.1671
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0016 0.0021 0.0017
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0215 0.2548 0.2544
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0147 0.1676 1
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0105 0.1144 0.1144
Loa Loa (eye worm) TK/FER protein kinase 0.0362 0.4412 1
Loa Loa (eye worm) hypothetical protein 0.0105 0.1144 0.2582
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0046 0.0397 0.047
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Leishmania major hypothetical protein, conserved 0.0105 0.1144 0.6826
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0147 0.1676 1
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.1676 0.34
Echinococcus granulosus tyrosine protein kinase Lyn 0.0362 0.4412 0.4409
Entamoeba histolytica SH2 domain containing protein 0.0215 0.2548 0.5504
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0147 0.1676 0.34
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0038 0.0293 0.0246
Loa Loa (eye worm) hypothetical protein 0.0147 0.1676 0.379
Trichomonas vaginalis CAMK family protein kinase 0.0147 0.1676 0.555
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1909 0.633
Loa Loa (eye worm) TK/FER protein kinase 0.0147 0.1676 0.379
Mycobacterium tuberculosis Probable lipase LipD 0.0105 0.1144 0.1368
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Echinococcus granulosus neuropeptide receptor A26 0.0449 0.5518 0.5516
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Entamoeba histolytica protein kinase, putative 0.0147 0.1676 0.34
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.1676 0.34
Plasmodium falciparum glutathione reductase 0.0046 0.0394 0.2324
Loa Loa (eye worm) hypothetical protein 0.0034 0.0249 0.0552
Onchocerca volvulus 0.0362 0.4412 1
Echinococcus granulosus SH2 motif 0.0215 0.2548 0.2544
Echinococcus granulosus 3'partial|retinal guanylyl cyclase 2 0.0147 0.1676 0.1671
Onchocerca volvulus Huntingtin homolog 0.0119 0.1321 0.268
Loa Loa (eye worm) SH2 domain-containing protein 0.0215 0.2548 0.5769
Echinococcus granulosus tyrosine protein kinase shark 0.0362 0.4412 0.4409
Entamoeba histolytica tyrosine kinase, putative 0.0147 0.1676 0.34
Onchocerca volvulus 0.0147 0.1676 0.3521
Schistosoma mansoni ferritin light chain 0.0016 0.0021 0.0021
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0147 0.1676 0.1671
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0147 0.1676 0.1671
Echinococcus multilocularis insulin receptor 0.0147 0.1676 0.1671
Trichomonas vaginalis penicillin-binding protein, putative 0.0105 0.1144 0.3774
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0006 0.0037
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0362 0.4412 0.4409
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.3009 1
Loa Loa (eye worm) TK/EPH protein kinase 0.0147 0.1676 0.379
Plasmodium falciparum glutathione reductase 0.0016 0.0014 0.0045
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0362 0.4412 1
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0362 0.4412 0.4409
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.1289 0.1542
Loa Loa (eye worm) TK/RYK protein kinase 0.0147 0.1676 0.379
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0022 0.0022
Echinococcus multilocularis SH2 motif 0.0215 0.2548 0.2544
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.379
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0147 0.1676 0.1671
Entamoeba histolytica ankyrin repeat protein 0.0147 0.1676 0.34
Echinococcus multilocularis natriuretic peptide receptor 1 0.0147 0.1676 0.1671
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0006 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0147 0.1676 0.555
Echinococcus multilocularis neuropeptide receptor A26 0.0449 0.5518 0.5516
Schistosoma mansoni tyrosine kinase 0.0147 0.1676 0.1676
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0032 0.0219 0.1562
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.379
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.379
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Giardia lamblia Kinase, NEK 0.0147 0.1676 1
Loa Loa (eye worm) TK protein kinase 0.0147 0.1676 0.379
Loa Loa (eye worm) beta-lactamase 0.0105 0.1144 0.2582
Brugia malayi chromobox protein homolog 3 0.0038 0.0293 0.0651
Schistosoma mansoni hypothetical protein 0.0164 0.1896 0.1896
Echinococcus granulosus tyrosine protein kinase Fyn 0.0362 0.4412 0.4409
Schistosoma mansoni tyrosine kinase 0.0147 0.1676 0.1676
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.379
Entamoeba histolytica tyrosine kinase, putative 0.0147 0.1676 0.34
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0774 1
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0147 0.1676 0.1671
Treponema pallidum bacterioferrin (TpF1) 0.0016 0.0021 0.0091
Entamoeba histolytica protein kinase, putative 0.0147 0.1676 0.34
Echinococcus granulosus growth factor receptor bound protein 2 0.0215 0.2548 0.2544
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0774 0.0768
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1909 0.633
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.3009 1
Echinococcus multilocularis tyrosine protein kinase transmembrane receptor 0.0147 0.1676 0.1671
Schistosoma mansoni protein kinase 0.0147 0.1676 0.1676
Loa Loa (eye worm) TK protein kinase 0.0147 0.1676 0.379
Echinococcus multilocularis activated cdc42 kinase 1 0.0147 0.1676 0.1671
Loa Loa (eye worm) hypothetical protein 0.0105 0.1144 0.2582
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0016 0.0014 0.0081
Loa Loa (eye worm) cytokine inducible SH2-containing protein 5 0.0215 0.2548 0.5769
Schistosoma mansoni tyrosine kinase 0.0147 0.1676 0.1676
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0254 0.0248
Loa Loa (eye worm) heterochromatin protein 1 0.0068 0.067 0.1507
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0362 0.4412 0.4409
Entamoeba histolytica protein kinase, putative 0.0147 0.1676 0.34
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0147 0.1676 0.34
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0215 0.2548 0.2544
Echinococcus multilocularis tyrosine protein kinase pr2 0.0147 0.1676 0.1671
Echinococcus multilocularis SH2 motif 0.0215 0.2548 0.2544
Brugia malayi Immunoglobulin I-set domain containing protein 0.0147 0.1676 0.379
Brugia malayi Protein kinase domain containing protein 0.0362 0.4412 1
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.379
Plasmodium falciparum tyrosine kinase-like protein 0.0147 0.1676 1
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0147 0.1676 0.34
Brugia malayi Sex muscle abnormal protein 5 0.0215 0.2548 0.5769
Echinococcus multilocularis protein tyrosine kinase 0.0147 0.1676 0.1671
Loa Loa (eye worm) TK protein kinase 0.0147 0.1676 0.379
Loa Loa (eye worm) hypothetical protein 0.0215 0.2548 0.5769
Entamoeba histolytica hypothetical protein 0.0147 0.1678 0.3404
Brugia malayi tRNA modification GTPase TrmE family protein 0.0215 0.2548 0.5769
Brugia malayi SH2 domain containing protein 0.0215 0.2548 0.5769
Leishmania major 4-coumarate:coa ligase-like protein 0.0046 0.0397 0.2371
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0225 0.0264
Loa Loa (eye worm) hypothetical protein 0.0147 0.1676 0.379
Entamoeba histolytica serine/threonine kinase, putative 0.0147 0.1676 0.34
Trichomonas vaginalis conserved hypothetical protein 0.0147 0.1676 0.555
Brugia malayi SH2 domain containing protein 0.0215 0.2548 0.5769
Onchocerca volvulus Suppressor of cytokine signaling 7 homolog 0.0215 0.2548 0.5586
Echinococcus multilocularis ferritin 0.0016 0.0021 0.0014
Brugia malayi Protein kinase domain containing protein 0.0362 0.4412 1
Schistosoma mansoni growth factor receptor-bound protein 0.0215 0.2548 0.2548
Schistosoma mansoni ferritin 0.0016 0.0021 0.0021
Entamoeba histolytica protein kinase, putative 0.0147 0.1676 0.34
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Loa Loa (eye worm) hypothetical protein 0.0147 0.1676 0.379
Schistosoma mansoni tyrosine kinase 0.0147 0.1676 0.1676
Loa Loa (eye worm) TK/FER protein kinase 0.0147 0.1676 0.379
Echinococcus multilocularis retinal guanylyl cyclase 2 0.0147 0.1676 0.1671
Leishmania major trypanothione reductase 0.0046 0.0394 0.2352
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0034 0.0249 0.31
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0147 0.1676 0.34
Loa Loa (eye worm) hypothetical protein 0.0147 0.1676 0.379
Schistosoma mansoni tyrosine-protein kinase zap-70 0.0215 0.2548 0.2548
Schistosoma mansoni SH2A 0.0215 0.2548 0.2548
Plasmodium falciparum protein kinase, putative 0.0147 0.1676 1
Brugia malayi STAT protein, DNA binding domain containing protein 0.0215 0.2548 0.5769
Loa Loa (eye worm) RGC/RGC protein kinase 0.0147 0.1676 0.379
Trypanosoma brucei protein kinase, putative 0.0147 0.1676 1
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.1676 0.34
Schistosoma mansoni inositol monophosphatase 0.0036 0.0266 0.0266
Mycobacterium ulcerans bacterioferritin BfrB 0.0016 0.0021 0.0061
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.1676 0.34
Echinococcus multilocularis tensin 0.0215 0.2548 0.2544
Echinococcus multilocularis tensin 0.0215 0.2548 0.2544
Echinococcus multilocularis suppressor of cytokine signaling 7 0.0215 0.2548 0.2544
Echinococcus granulosus activin receptor type 0.0147 0.1676 0.1671
Echinococcus multilocularis c src tyrosine kinase 0.0362 0.4412 0.4409
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.1676 0.34
Echinococcus granulosus suppressor of cytokine signaling 6 0.0215 0.2548 0.2544
Loa Loa (eye worm) hypothetical protein 0.0147 0.1676 0.379
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0016 0.0014 0.0081
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.379
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0147 0.1676 0.1671
Schistosoma mansoni tyrosine kinase 0.0362 0.4412 0.4412
Brugia malayi SH2 domain containing protein 0.0215 0.2548 0.5769
Echinococcus multilocularis zinc finger protein 0.0019 0.0053 0.0046
Loa Loa (eye worm) serine/threonine protein kinase 0.0147 0.1676 0.379
Entamoeba histolytica tyrosine kinase, putative 0.0147 0.1676 0.34
Schistosoma mansoni tyrosine kinase 0.0147 0.1676 0.1676
Trichomonas vaginalis penicillin-binding protein, putative 0.0105 0.1144 0.3774
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0017 0.0022 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0293 0.0932
Echinococcus multilocularis tyrosine kinase 0.0362 0.4412 0.4409
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Trichomonas vaginalis conserved hypothetical protein 0.0147 0.1676 0.555
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0329 0.1054
Echinococcus granulosus tyrosine protein kinase Src64B 0.0362 0.4412 0.4409
Entamoeba histolytica protein kinase with ankyrin repeats, putative 0.0147 0.1676 0.34
Entamoeba histolytica hypothetical protein 0.0147 0.1676 0.34
Echinococcus granulosus insulin growth factor 1 receptor beta 0.0147 0.1676 0.1671
Schistosoma mansoni tyrosine kinase 0.0147 0.1676 0.1676
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.1676 0.34
Echinococcus granulosus kinase suppressor of Ras 1 0.0147 0.1676 0.1671
Echinococcus granulosus NCK adaptor protein 0.0215 0.2548 0.2544
Brugia malayi Probable ClpP-like protease 0.0076 0.0774 0.1742
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0046 0.0397 0.3395
Echinococcus granulosus tyrosine protein kinase csk 0.0147 0.1676 0.1671
Entamoeba histolytica hypothetical protein 0.0147 0.1676 0.34
Loa Loa (eye worm) TK/FER protein kinase 0.0362 0.4412 1
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0147 0.1676 1
Trichomonas vaginalis esterase, putative 0.0105 0.1144 0.3774
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Echinococcus granulosus SH2 motif 0.0215 0.2548 0.2544
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Trichomonas vaginalis conserved hypothetical protein 0.0147 0.1676 0.555
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.1676 0.34
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0774 0.0774
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Giardia lamblia Kinase 0.0147 0.1676 1
Echinococcus granulosus tyrosine protein kinase csk 0.0147 0.1676 0.1671
Brugia malayi proto-oncogene tyrosine-protein kinase FER 0.0147 0.1676 0.379
Echinococcus granulosus epidermal growth factor receptor 0.0147 0.1676 0.1671
Entamoeba histolytica tyrosine kinase, putative 0.0147 0.1676 0.34
Loa Loa (eye worm) RGC/RGC protein kinase 0.0147 0.1676 0.379
Echinococcus multilocularis N chimaerin 0.0215 0.2548 0.2544
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0147 0.1676 0.379
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Loa Loa (eye worm) TK/FER protein kinase 0.0147 0.1676 0.379
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0215 0.2548 0.5769
Onchocerca volvulus 0.0215 0.2548 0.5586
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0362 0.4412 0.4409
Loa Loa (eye worm) hypothetical protein 0.0215 0.2548 0.5769
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.1676 0.34
Brugia malayi Guanylyl cyclase protein 23 0.0147 0.1676 0.379
Trypanosoma brucei Flagellum attachment zone protein 20 0.0147 0.1676 1
Echinococcus multilocularis SHC transforming protein 3 0.0215 0.2548 0.2544
Loa Loa (eye worm) TK/FAK protein kinase 0.0147 0.1676 0.379
Echinococcus multilocularis growth factor receptor bound protein 2 0.0215 0.2548 0.2544
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0774 0.4598
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0362 0.4412 0.4409
Loa Loa (eye worm) hypothetical protein 0.0147 0.1676 0.379
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Onchocerca volvulus 0.0147 0.1676 0.3521
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Plasmodium vivax glutathione reductase, putative 0.0046 0.0394 0.2324
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.1676 0.34
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.1676 0.34
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0022 0.0015
Schistosoma mansoni ferritin 0.0016 0.0021 0.0021
Echinococcus granulosus tyrosine protein kinase Src42A 0.0215 0.2548 0.2544
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0266 0.0843
Schistosoma mansoni hypothetical protein 0.0147 0.1676 0.1676
Echinococcus granulosus insulin receptor 0.0147 0.1676 0.1671
Entamoeba histolytica tyrosine kinase, putative 0.0147 0.1676 0.34
Onchocerca volvulus 0.0105 0.1144 0.2261
Brugia malayi beta-lactamase 0.0105 0.1144 0.2582
Brugia malayi Variant SH3 domain containing protein 0.0215 0.2548 0.5769
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0016 0.0014 0.0081
Echinococcus multilocularis phosphatidylinositol 3 kinase regulatory subunit 0.0215 0.2548 0.2544
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0076 0.0774 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0046 0.0397 0.0316
Mycobacterium tuberculosis Possible penicillin-binding protein 0.067 0.8323 1
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0394 0.0467
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0015 0.0006 0.0037
Echinococcus granulosus tyrosine protein kinase pr2 0.0147 0.1676 0.1671
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0225 0.0264
Schistosoma mansoni inositol monophosphatase 0.0036 0.0266 0.0266
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0362 0.4412 0.4409
Onchocerca volvulus 0.0147 0.1676 0.3521
Brugia malayi beta-lactamase family protein 0.0105 0.1144 0.2582
Entamoeba histolytica protein kinase, putative 0.0147 0.1676 0.34
Entamoeba histolytica protein kinase, putative 0.0147 0.1676 0.34
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0147 0.1676 0.1676
Schistosoma mansoni src-type protein tyrosine kinase-related 0.0147 0.1676 0.1676
Loa Loa (eye worm) hypothetical protein 0.0215 0.2548 0.5769
Brugia malayi SRC-1 0.0362 0.4412 1
Brugia malayi SH2 domain containing protein 0.0362 0.4412 1
Echinococcus granulosus tyrosine kinase 0.0362 0.4412 0.4409
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0147 0.1676 0.34
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0362 0.4412 0.4409
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.1676 0.34
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0046 0.0397 0.3395
Onchocerca volvulus 0.0362 0.4412 1
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0394 0.2352
Entamoeba histolytica tyrosine kinase, putative 0.0147 0.1676 0.34
Loa Loa (eye worm) hypothetical protein 0.0215 0.2548 0.5769
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0105 0.1144 0.1368
Echinococcus granulosus tensin C1 domain containing phosphatase 0.0215 0.2548 0.2544
Echinococcus multilocularis expressed protein 0.0016 0.0021 0.0014
Leishmania major protein kinase, putative 0.0147 0.1676 1
Schistosoma mansoni tyrosine kinase 0.0147 0.1676 0.1676
Echinococcus multilocularis SH2 motif 0.0215 0.2548 0.2544
Brugia malayi Bromodomain containing protein 0.0037 0.0283 0.0628
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0362 0.4412 0.4409
Loa Loa (eye worm) TK protein kinase 0.0147 0.1676 0.379
Echinococcus multilocularis 0.0215 0.2548 0.2544
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0147 0.1676 0.3521
Schistosoma mansoni tensin-related 0.0215 0.2548 0.2548
Loa Loa (eye worm) TK/FER protein kinase 0.0362 0.4412 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.1289 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0774 0.4598
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0089 0.0083
Mycobacterium tuberculosis Probable lipase LipE 0.0105 0.1144 0.1368
Schistosoma mansoni tyrosine kinase 0.0147 0.1676 0.1676
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0014 0.0007
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0041 0.0329 0.0333
Entamoeba histolytica ankyrin repeat protein 0.0147 0.1676 0.34
Entamoeba histolytica protein kinase, putative 0.0147 0.1678 0.3404
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0152 0.0463
Entamoeba histolytica hypothetical protein 0.0147 0.1678 0.3404
Toxoplasma gondii protein kinase domain-containing protein 0.0147 0.1676 1
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0105 0.1144 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0362 0.4412 0.4409
Toxoplasma gondii hypothetical protein 0.0026 0.0143 0.0821
Schistosoma mansoni tyrosine kinase 0.0147 0.1676 0.1676
Brugia malayi SH2 domain containing protein 0.0215 0.2548 0.5769
Entamoeba histolytica serine/threonine kinase, putative 0.0147 0.1676 0.34
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0397 0.0888
Entamoeba histolytica acyl-coA synthetase, putative 0.0046 0.0397 0.0316
Echinococcus multilocularis integrin linked protein kinase 0.0147 0.1676 0.1671
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0014 0.0007
Mycobacterium ulcerans lipase LipD 0.0105 0.1144 1
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Giardia lamblia Protein 21.1 0.0147 0.1676 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0026 0.0143 0.1705
Mycobacterium ulcerans hypothetical protein 0.0105 0.1144 1
Schistosoma mansoni ferritin light chain 0.0016 0.0021 0.0021
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0016 0.0014 0.0045
Toxoplasma gondii protein kinase 0.0147 0.1676 1
Schistosoma mansoni tensin 0.0215 0.2548 0.2548
Brugia malayi SH2 domain containing protein 0.0215 0.2548 0.5769
Trypanosoma brucei trypanothione reductase 0.0046 0.0394 0.2352
Schistosoma mansoni serine/threonine RGC 0.0147 0.1676 0.1676
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0362 0.4412 0.4409
Echinococcus multilocularis tyrosine protein kinase Srms 0.0362 0.4412 0.4409
Entamoeba histolytica hypothetical protein 0.0147 0.1676 0.34
Brugia malayi Furin-like cysteine rich region family protein 0.0147 0.1676 0.379
Schistosoma mansoni tensin 0.0215 0.2548 0.2548
Toxoplasma gondii thioredoxin reductase 0.0046 0.0394 0.2324
Entamoeba histolytica tyrosine kinase, putative 0.0147 0.1676 0.34
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Schistosoma mansoni tyrosine kinase 0.0147 0.1676 0.1676
Brugia malayi SH2 domain containing protein 0.0362 0.4412 1
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0014 0.0081
Entamoeba histolytica tyrosin kinase, putative 0.0147 0.1676 0.34
Plasmodium vivax hypothetical protein, conserved 0.0105 0.1144 0.6814
Trichomonas vaginalis serine-threonine protein kinase, putative 0.0147 0.1676 0.555
Entamoeba histolytica tyrosin kinase, putative 0.0147 0.1676 0.34
Loa Loa (eye worm) SH2 domain-containing protein 0.0215 0.2548 0.5769
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0442 0.0525
Schistosoma mansoni vav2 0.0215 0.2548 0.2548
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0362 0.4412 0.4409
Schistosoma mansoni tyrosine kinase 0.0147 0.1676 0.1676
Brugia malayi C-terminal src kinase protein 1 0.0147 0.1676 0.379
Loa Loa (eye worm) hypothetical protein 0.0147 0.1676 0.379
Loa Loa (eye worm) TK/FER protein kinase 0.0362 0.4412 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0362 0.4412 0.4409
Entamoeba histolytica serine/threonine kinase, putative 0.0147 0.1676 0.34
Loa Loa (eye worm) hypothetical protein 0.0037 0.0284 0.063
Trichomonas vaginalis br serine/threonine-protein kinase, putative 0.0147 0.1676 0.555
Brugia malayi AMP-binding enzyme family protein 0.0046 0.0397 0.0888
Schistosoma mansoni tyrosine kinase 0.0147 0.1676 0.1676
Onchocerca volvulus 0.0105 0.1144 0.2261
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0266 0.026
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0017 0.0022 0.0022
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0397 0.3395
Schistosoma mansoni tyrosine kinase 0.0147 0.1676 0.1676
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Entamoeba histolytica protein kinase, putative 0.0147 0.1676 0.34
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.1676 0.34
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.379
Mycobacterium leprae conserved hypothetical protein 0.0105 0.1144 0.8858
Entamoeba histolytica serine/threonine kinase, putative 0.0147 0.1676 0.34
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0147 0.1676 0.1671
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0266 0.026
Trichomonas vaginalis chromobox protein, putative 0.0041 0.0329 0.1054
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0442 0.0437
Echinococcus multilocularis basic fibroblast growth factor receptor 1 A 0.0147 0.1676 0.1671
Mycobacterium ulcerans acyl-CoA synthetase 0.0046 0.0397 0.3395
Echinococcus granulosus tyrosine protein kinase csk 0.0147 0.1676 0.1671
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0442 0.3327
Leishmania major hypothetical protein, conserved 0.0147 0.1676 1
Schistosoma mansoni protein kinase 0.0147 0.1676 0.1676
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0105 0.114 0.1364
Brugia malayi protein-tyrosine kinase 0.0362 0.4412 1
Echinococcus granulosus fibroblast growth factor receptor 4 0.0147 0.1676 0.1671
Echinococcus granulosus ephrin type A receptor 4 A 0.0147 0.1676 0.1671
Loa Loa (eye worm) hypothetical protein 0.0068 0.0682 0.1533
Loa Loa (eye worm) hypothetical protein 0.0038 0.0293 0.0651
Schistosoma mansoni suppressor of cytokine signaling 0.0215 0.2548 0.2548
Schistosoma mansoni tyrosine kinase 0.0147 0.1676 0.1676
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Echinococcus granulosus tyrosine protein kinase ABL1 0.0362 0.4412 0.4409
Schistosoma mansoni tyrosine kinase 0.0147 0.1676 0.1676
Mycobacterium ulcerans esterase/lipase LipP 0.0105 0.1144 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0362 0.4412 0.4409
Onchocerca volvulus 0.0105 0.1144 0.2261
Loa Loa (eye worm) hypothetical protein 0.0105 0.1144 0.2582
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0022 0.0022
Entamoeba histolytica tyrosine kinase, putative 0.0147 0.1676 0.34
Schistosoma mansoni hypothetical protein 0.0215 0.2548 0.2548
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.379
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0105 0.1144 0.2582
Echinococcus granulosus natriuretic peptide receptor 1 0.0147 0.1676 0.1671
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0215 0.2548 0.2548
Mycobacterium tuberculosis Conserved protein 0.0105 0.1144 0.1368
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0147 0.1676 0.34
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0215 0.2548 0.5504
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.379
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0022 0.0015
Loa Loa (eye worm) TKL/RAF/KSR protein kinase 0.0147 0.1676 0.379
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0362 0.4412 0.4412
Schistosoma mansoni serine/threonine protein kinase 0.0147 0.1676 0.1676
Brugia malayi Adenylate and Guanylate cyclase catalytic domain containing protein 0.0147 0.1676 0.379
Brugia malayi Receptor family ligand binding region containing protein 0.0147 0.1676 0.379
Onchocerca volvulus 0.0215 0.2548 0.5586
Mycobacterium tuberculosis Probable hydrolase 0.0105 0.1144 0.1368
Entamoeba histolytica receptor protein kinase, putative 0.0147 0.1676 0.34
Loa Loa (eye worm) RGC/RGC protein kinase 0.0147 0.1676 0.379
Entamoeba histolytica serine/threonine kinase, putative 0.0147 0.1676 0.34
Plasmodium vivax tyrosine kinase-like protein, putative 0.0147 0.1676 1
Brugia malayi RhoGAP domain containing protein 0.0215 0.2548 0.5769
Echinococcus multilocularis raf serine:threonine protein kinase 0.0147 0.1676 0.1671
Loa Loa (eye worm) hypothetical protein 0.0147 0.1676 0.379
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0014 0.0081
Entamoeba histolytica hypothetical protein 0.0147 0.1678 0.3404
Loa Loa (eye worm) TK protein kinase 0.0147 0.1676 0.379
Trichomonas vaginalis D-aminoacylase, putative 0.0105 0.1144 0.3774
Mycobacterium tuberculosis Probable esterase LipL 0.0105 0.1144 0.1368
Echinococcus granulosus chromobox protein 1 0.0068 0.067 0.0664
Loa Loa (eye worm) TK/ABL protein kinase 0.0362 0.4412 1
Echinococcus granulosus retinal guanylyl cyclase 2 0.0147 0.1676 0.1671
Trichomonas vaginalis glucosylceramidase, putative 0.0165 0.1909 0.633
Loa Loa (eye worm) TK/ALK protein kinase 0.0147 0.1676 0.379
Plasmodium falciparum protein kinase, putative 0.0147 0.1676 1
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Loa Loa (eye worm) hypothetical protein 0.0215 0.2548 0.5769
Echinococcus granulosus suppressor of cytokine signaling 7 0.0215 0.2548 0.2544
Echinococcus multilocularis atrial natriuretic peptide receptor 1 0.0147 0.1676 0.1671
Echinococcus granulosus integrin linked protein kinase 0.0147 0.1676 0.1671
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0147 0.1676 0.34
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.379
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Loa Loa (eye worm) TK/Met protein kinase 0.0147 0.1676 0.379
Schistosoma mansoni zinc finger protein 0.0019 0.0053 0.0053
Loa Loa (eye worm) TK protein kinase 0.0147 0.1676 0.379
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0147 0.1676 0.34
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0147 0.1676 0.555
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0215 0.2548 0.5769
Entamoeba histolytica tyrosine kinase, putative 0.0147 0.1676 0.34
Schistosoma mansoni ferritin 0.0016 0.0021 0.0021
Echinococcus granulosus tyrosine protein kinase Fyn 0.0362 0.4412 0.4409
Entamoeba histolytica protein tyrosine kinase domain-containing protein 0.0147 0.1676 0.34
Trichomonas vaginalis glucosylceramidase, putative 0.0252 0.3009 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0105 0.1144 0.1368
Echinococcus multilocularis microtubule associated protein 2 0.0802 1 1
Entamoeba histolytica tyrosin kinase, putative 0.0147 0.1676 0.34
Entamoeba histolytica protein kinase, putative 0.0147 0.1676 0.34
Entamoeba histolytica protein kinase, putative 0.0147 0.1676 0.34
Brugia malayi SH2 domain containing protein 0.0215 0.2548 0.5769
Schistosoma mansoni apoferritin-2 0.0016 0.0021 0.0021
Loa Loa (eye worm) TK protein kinase 0.0147 0.1676 0.379
Plasmodium vivax protein kinase, putative 0.0147 0.1676 1
Loa Loa (eye worm) hypothetical protein 0.0215 0.2548 0.5769
Trypanosoma cruzi hypothetical protein, conserved 0.0105 0.1144 0.6826
Brugia malayi hypothetical protein 0.0119 0.1321 0.2984
Schistosoma mansoni tyrosine kinase 0.0147 0.1676 0.1676
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0147 0.1676 0.1671
Entamoeba histolytica receptor protein kinase, putative 0.0147 0.1676 0.34
Trichomonas vaginalis protein kinase atn1, putative 0.0147 0.1676 0.555
Echinococcus granulosus phosphatidylinositol 3 kinase regulatory subunit 0.0215 0.2548 0.2544
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.379
Schistosoma mansoni tyrosine kinase 0.0147 0.1676 0.1676
Schistosoma mansoni tensin-related 0.0215 0.2548 0.2548
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0016 0.0014 0.0081
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.1676 0.34
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0225 0.0264
Echinococcus granulosus chromobox protein 1 0.0068 0.067 0.0664
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0546 0.054
Loa Loa (eye worm) TK/FER protein kinase 0.0362 0.4412 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0105 0.1144 0.1144
Echinococcus multilocularis epidermal growth factor receptor 0.0147 0.1676 0.1671
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0016 0.0014 0.0081
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.379
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0546 0.054
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0394 0.0388
Entamoeba histolytica hypothetical protein 0.0147 0.1676 0.34
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0215 0.2548 0.2544
Brugia malayi PHD-finger family protein 0.0024 0.0118 0.0254
Entamoeba histolytica tyrosine kinase, putative 0.0147 0.1676 0.34
Schistosoma mansoni ferritin 0.0016 0.0021 0.0021
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0293 0.0932
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.379
Mycobacterium ulcerans bacterioferritin BfrA 0.0016 0.0021 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0152 0.0463
Loa Loa (eye worm) TK/FER protein kinase 0.0362 0.4412 1
Trypanosoma brucei hypothetical protein, conserved 0.0105 0.1144 0.6826
Echinococcus granulosus tyrosine kinase 0.0362 0.4412 0.4409
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0015 0.0006 0.0037
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0022 0.0022
Loa Loa (eye worm) TK/ACK protein kinase 0.0147 0.1676 0.379
Echinococcus granulosus hypothetical protein 0.0215 0.2548 0.2544
Brugia malayi bone morphogenetic protein type 1 receptor 0.0147 0.1676 0.379
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0215 0.2548 0.5769
Schistosoma mansoni protein tyrosine kinase 0.0147 0.1676 0.1676
Entamoeba histolytica tyrosine kinase, putative 0.0147 0.1676 0.34
Schistosoma mansoni nck2/grb4 0.0215 0.2548 0.2548
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0147 0.1676 0.1671
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Brugia malayi Protein kinase domain containing protein 0.0362 0.4412 1
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0016 0.0014 0.0081
Loa Loa (eye worm) SH2 domain-containing protein 0.0215 0.2548 0.5769
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0774 0.4598
Brugia malayi hypothetical protein 0.0147 0.1676 0.379
Entamoeba histolytica tyrosine kinase, putative 0.0147 0.1676 0.34
Echinococcus granulosus tyrosine protein kinase Fyn 0.0362 0.4412 0.4409
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0033 0.0225 0.0264
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0034 0.0249 0.2085
Echinococcus multilocularis epidermal growth factor receptor 0.0147 0.1676 0.1671
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.1676 0.34
Onchocerca volvulus 0.0147 0.1676 0.3521
Echinococcus multilocularis tyrosine protein kinase shark 0.0362 0.4412 0.4409
Echinococcus multilocularis tyrosine protein kinase HCK 0.0147 0.1676 0.1671
Echinococcus granulosus SHC transforming protein 3 0.0215 0.2548 0.2544
Entamoeba histolytica hypothetical protein 0.0147 0.1676 0.34
Trichomonas vaginalis chromobox protein, putative 0.0068 0.067 0.2192
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0015 0.0006 0.0037
Loa Loa (eye worm) TK/KIN6 protein kinase 0.0147 0.1676 0.379
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Trichomonas vaginalis chromobox protein, putative 0.0068 0.067 0.2192
Trichomonas vaginalis TKL family protein kinase 0.0147 0.1676 0.555
Brugia malayi Protein kinase domain containing protein 0.0362 0.4412 1
Loa Loa (eye worm) STAT protein 0.0215 0.2548 0.5769
Loa Loa (eye worm) hypothetical protein 0.0046 0.0397 0.0888
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0362 0.4412 0.4409
Schistosoma mansoni shc transforming protein 0.0215 0.2548 0.2548
Echinococcus granulosus activated cdc42 kinase 1 0.0147 0.1676 0.1671
Echinococcus multilocularis kinase suppressor of Ras 1 0.0147 0.1676 0.1671
Entamoeba histolytica protein kinase domain containing protein 0.0147 0.1676 0.34
Brugia malayi Protein kinase domain containing protein 0.0147 0.1676 0.379
Onchocerca volvulus 0.0215 0.2548 0.5586
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0016 0.0014 0.0045
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0394 0.0881
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0105 0.1144 0.1368

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.522 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.314 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.153 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.069 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.005 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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