TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 263.291 | Formula: C17H13NO2
H donors: 1 H acceptors: 2 LogP: 3.15 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: CNC(=O)C1=C(c2ccccc2)c2c(C1=O)cccc2
InChi: 1S/C17H13NO2/c1-18-17(20)15-14(11-7-3-2-4-8-11)12-9-5-6-10-13(12)16(15)19/h2-10H,1H3,(H,18,20)
InChiKey: GQNITLCGPGUTQT-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	mitogen activated protein kinase, putative,map kinase, putative	0.0051	0.0724	0.0653
Schistosoma mansoni	hypothetical protein	0.0096	0.1683	0.2597
Trypanosoma brucei	mitogen activated protein kinase 4, putative	0.0051	0.0724	1
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0466	0.0677
Leishmania major	hypothetical protein, conserved	0.0034	0.0381	0.028
Toxoplasma gondii	hypothetical protein	0.0027	0.0223	0.0108
Brugia malayi	beta-lactamase	0.0034	0.0381	0.0261
Loa Loa (eye worm)	PHD-finger family protein	0.0019	0.0057	0.0057
Leishmania major	macrophage migration inhibitory factor-like protein	0.046	0.9324	1
Echinococcus multilocularis	GTP binding nuclear protein Ran	0.0022	0.0123	0.0087
Echinococcus granulosus	mothers against decapentaplegic 5	0.0023	0.0149	0.0113
Brugia malayi	Thyroglobulin type-1 repeat family protein	0.007	0.1134	0.1023
Brugia malayi	Probable ClpP-like protease	0.0078	0.1293	0.1185
Schistosoma mansoni	bromodomain containing protein	0.0058	0.0877	0.1326
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0027	0.0223	0.0108
Schistosoma mansoni	hypothetical protein	0.0184	0.3531	0.5511
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.017	0.0051
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0051	0.0731	0.4744
Trichomonas vaginalis	importin beta-1, putative	0.0024	0.017	0.0051
Echinococcus granulosus	inositol monophosphatase 1	0.0038	0.0466	0.0431
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0078	0.1293	0.1261
Leishmania major	mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440	0.0051	0.0724	0.0653
Schistosoma mansoni	ran	0.0022	0.0123	0.0136
Plasmodium vivax	hypothetical protein, conserved	0.0034	0.0381	0.028
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0141	0.2619	0.2619
Echinococcus granulosus	peptidase Clp S14 family	0.0051	0.0731	0.0697
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0078	0.1293	0.1261
Loa Loa (eye worm)	hypothetical protein	0.0035	0.0398	0.0398
Echinococcus multilocularis	lamin	0.0057	0.0865	0.0831
Brugia malayi	beta-lactamase family protein	0.0034	0.0381	0.0261
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0381	0.0381
Loa Loa (eye worm)	hypothetical protein	0.0492	1	1
Trichomonas vaginalis	set domain proteins, putative	0.0442	0.896	0.9605
Brugia malayi	MH1 domain containing protein	0.0023	0.0149	0.0027
Loa Loa (eye worm)	hypothetical protein	0.0028	0.0241	0.0241
Loa Loa (eye worm)	hypothetical protein	0.0133	0.2459	0.2459
Schistosoma mansoni	hypothetical protein	0.0319	0.6377	1
Schistosoma mansoni	smad	0.0023	0.0149	0.0178
Entamoeba histolytica	myo-inositol monophosphatase, putative	0.0038	0.0466	0.0373
Trichomonas vaginalis	penicillin-binding protein, putative	0.0034	0.0381	0.028
Schistosoma mansoni	intermediate filament proteins	0.0057	0.0865	0.1306
Loa Loa (eye worm)	cytoplasmic intermediate filament protein	0.0031	0.0305	0.0305
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.01	0.1769	0.1666
Onchocerca volvulus		0.0057	0.0865	0.0563
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0219	0.0219
Trichomonas vaginalis	D-aminoacylase, putative	0.0034	0.0381	0.028
Loa Loa (eye worm)	hypothetical protein	0.007	0.1134	0.1134
Echinococcus granulosus	geminin	0.0184	0.3531	0.3507
Schistosoma mansoni	smad1 5 8 and	0.0023	0.0149	0.0178
Brugia malayi	Inositol-1	0.0038	0.0466	0.0347
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1683	0.1683
Echinococcus granulosus	smad	0.0023	0.0149	0.0113
Toxoplasma gondii	inositol(myo)-1(or 4)-monophosphatase 2, putative	0.0038	0.0466	0.0373
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0724	0.0653
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0724	0.0653
Onchocerca volvulus	Huntingtin homolog	0.0133	0.2459	0.2421
Onchocerca volvulus		0.0056	0.0832	0.0526
Onchocerca volvulus		0.01	0.1769	0.1618
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0865	0.0865
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0045	0.0596	0.0562
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0141	0.2619	0.2527
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1293	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0466	0.0373
Loa Loa (eye worm)	hypothetical protein	0.0133	0.2459	0.2459
Leishmania major	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0466	0.0373
Echinococcus multilocularis	cytoplasmic intermediate filament protein	0.0028	0.0241	0.0205
Echinococcus granulosus	GTP binding nuclear protein Ran	0.0022	0.0123	0.0087
Schistosoma mansoni	hypothetical protein	0.0045	0.0596	0.0883
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0056	0.0832	0.0798
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0843	0.0843
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0045	0.0596	0.0562
Brugia malayi	PHD-finger family protein	0.0023	0.0139	0.0016
Brugia malayi	Intermediate filament tail domain containing protein	0.0057	0.0865	0.0751
Onchocerca volvulus		0.007	0.1134	0.0877
Onchocerca volvulus		0.007	0.1134	0.0877
Echinococcus multilocularis	geminin	0.0184	0.3531	0.3507
Loa Loa (eye worm)	hypothetical protein	0.007	0.1134	0.1134
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0078	0.1293	1
Brugia malayi	intermediate filament protein	0.0057	0.0865	0.0751
Trypanosoma cruzi	mitogen activated protein kinase 2, putative	0.0051	0.0724	1
Toxoplasma gondii	HEAT repeat-containing protein	0.003	0.0289	0.0181
Loa Loa (eye worm)	intermediate filament tail domain-containing protein	0.0057	0.0865	0.0865
Loa Loa (eye worm)	hypothetical protein	0.0039	0.0481	0.0481
Trypanosoma brucei	protein kinase, putative	0.0051	0.0724	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0034	0.0381	0.0543
Loa Loa (eye worm)	intermediate filament protein	0.0057	0.0865	0.0865
Echinococcus granulosus	survival motor neuron protein 1	0.0492	1	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0141	0.2619	0.2527
Onchocerca volvulus		0.0442	0.896	1
Echinococcus multilocularis	lamin dm0	0.0057	0.0865	0.0831
Trypanosoma cruzi	hypothetical protein, conserved	0.0034	0.0381	0.4292
Mycobacterium leprae	Probable lipase LipE	0.0034	0.0381	0.1479
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0034	0.0381	0.0543
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0054	0.0789	0.0755
Echinococcus multilocularis	smad	0.0023	0.0149	0.0113
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0724	0.0653
Echinococcus multilocularis	mitogen activated protein kinase	0.0051	0.0724	0.069
Echinococcus multilocularis	Smad4	0.0023	0.0149	0.0113
Schistosoma mansoni	smad1 5 8 and	0.0023	0.0149	0.0178
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0056	0.0832	0.1255
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0021	0.0094	0.009
Trichomonas vaginalis	penicillin-binding protein, putative	0.0034	0.0381	0.028
Loa Loa (eye worm)	beta-lactamase	0.0034	0.0381	0.0381
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0389	0.7831	0.7831
Schistosoma mansoni	hypothetical protein	0.0019	0.0057	0.0032
Loa Loa (eye worm)	nucleolar RNA-associated protein alpha	0.0319	0.6377	0.6377
Trichomonas vaginalis	conserved hypothetical protein	0.046	0.9324	1
Echinococcus granulosus	Smad4	0.0023	0.0149	0.0113
Loa Loa (eye worm)	hypothetical protein	0.003	0.0289	0.0289
Brugia malayi	MH2 domain containing protein	0.0023	0.0149	0.0027
Mycobacterium tuberculosis	Inositol-1-monophosphatase SuhB	0.0034	0.0382	0.0001
Schistosoma mansoni	survival motor neuron protein	0.01	0.1769	0.2733
Echinococcus multilocularis	TGF beta signal transducer SmadC	0.0023	0.0149	0.0113
Echinococcus granulosus	mitogen activated protein kinase	0.0051	0.0724	0.069
Plasmodium falciparum	importin beta, putative	0.003	0.0289	0.0181
Loa Loa (eye worm)	inositol-1	0.0038	0.0466	0.0466
Loa Loa (eye worm)	hypothetical protein	0.007	0.1134	0.1134
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1293	1
Loa Loa (eye worm)	Smad1	0.0023	0.0149	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0381	0.0381
Loa Loa (eye worm)	macrophage migration inhibitory factor	0.046	0.9324	0.9324
Trichomonas vaginalis	esterase, putative	0.0034	0.0381	0.028
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0051	0.0731	0.0899
Trypanosoma cruzi	importin beta-1 subunit, putative	0.0024	0.017	0.0784
Echinococcus granulosus	beta LACTamase domain containing family member	0.0034	0.0381	0.0346
Loa Loa (eye worm)	thyroglobulin type-1 repeat family protein	0.007	0.1134	0.1134
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0034	0.0381	0.0381
Schistosoma mansoni	hypothetical protein	0.0184	0.3531	0.5511
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0078	0.1293	0.1272
Loa Loa (eye worm)	hypothetical protein	0.007	0.1134	0.1134
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.1293	0.1272
Loa Loa (eye worm)	hypothetical protein	0.0071	0.116	0.116
Entamoeba histolytica	macrophage migration inhibitory factor-like protein	0.046	0.9324	1
Loa Loa (eye worm)	hypothetical protein	0.0027	0.0219	0.0219
Loa Loa (eye worm)	hypothetical protein	0.0037	0.0444	0.0444
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.0724	1
Trichomonas vaginalis	CMGC family protein kinase	0.0051	0.0724	0.0653
Schistosoma mansoni	TGF-beta signal transducer Smad2	0.0023	0.0149	0.0178
Trichomonas vaginalis	Importin beta-1 subunit, putative	0.0024	0.017	0.0051
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0466	0.5704
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0021	0.0094	0.0057
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0034	0.0381	0.0261
Brugia malayi	cytoplasmic intermediate filament protein	0.0031	0.0305	0.0184
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0289	0.2763
Trypanosoma brucei	inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0466	0.5704
Brugia malayi	Smad1	0.0023	0.0149	0.0027
Loa Loa (eye worm)	MH1 domain-containing protein	0.0023	0.0149	0.0149
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0051	0.0731	0.0899
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0045	0.0596	0.0596
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0045	0.0596	0.0479
Brugia malayi	Thyroglobulin type-1 repeat family protein	0.007	0.1134	0.1023
Loa Loa (eye worm)	hypothetical protein	0.0141	0.2619	0.2619
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1293	1
Trypanosoma cruzi	mitogen-activated protein kinase 11, putative	0.0051	0.0724	1
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0045	0.0596	0.0562
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0055	0.0809	0.0775
Brugia malayi	MH1 domain containing protein	0.0023	0.0149	0.0027
Brugia malayi	latrophilin 2 splice variant baaae	0.0096	0.1683	0.1579
Schistosoma mansoni	ran	0.0022	0.0123	0.0136
Trichomonas vaginalis	D-aminoacylase, putative	0.0034	0.0381	0.028
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.023	0.4497	0.4497
Brugia malayi	beta-lactamase family protein	0.0034	0.0381	0.0261
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0055	0.0809	0.0775
Giardia lamblia	Kinase, CMGC MAPK	0.0051	0.0724	0.0653
Loa Loa (eye worm)	macrophage migration inhibitory factor 2	0.0242	0.4757	0.4757
Loa Loa (eye worm)	MH2 domain-containing protein	0.0023	0.0149	0.0149
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0381	0.0381
Schistosoma mansoni	lamin	0.0057	0.0865	0.1306
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0381	0.0381
Brugia malayi	Latrophilin receptor protein 2	0.0045	0.0596	0.0479
Brugia malayi	Bromodomain containing protein	0.0069	0.1103	0.0992
Brugia malayi	Importin beta-1 subunit	0.003	0.0289	0.0168
Leishmania major	macrophage migration inhibitory factor-like protein	0.046	0.9324	1
Schistosoma mansoni	hypothetical protein	0.0045	0.0596	0.0883
Echinococcus granulosus	mitogen activated protein kinase 3	0.0051	0.0724	0.069
Mycobacterium leprae	possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ).	0.0034	0.0382	0.1483
Schistosoma mansoni	importin beta-1	0.003	0.0289	0.0398
Schistosoma mansoni	hypothetical protein	0.01	0.1769	0.2733
Trichomonas vaginalis	inositol monophosphatase, putative	0.0038	0.0466	0.0373
Echinococcus granulosus	histone lysine methyltransferase setb	0.0071	0.116	0.1128
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1293	0.5
Trypanosoma brucei	hypothetical protein, conserved	0.0034	0.0381	0.4292
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0051	0.0731	0.0697
Echinococcus multilocularis	snurportin 1	0.0319	0.6377	0.6363
Echinococcus granulosus	intermediate filament protein	0.0057	0.0865	0.0831
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0078	0.1293	0.1272
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0219	0.4267	1
Trichomonas vaginalis	myo inositol monophosphatase, putative	0.0038	0.0466	0.0373
Echinococcus multilocularis	GPCR, family 2	0.0045	0.0596	0.0562
Echinococcus multilocularis	inositol monophosphatase 1	0.0038	0.0466	0.0431
Loa Loa (eye worm)	hypothetical protein	0.0065	0.1021	0.1021
Onchocerca volvulus		0.007	0.1134	0.0877
Echinococcus granulosus	fetal alzheimer antigen falz	0.0021	0.0094	0.0057
Onchocerca volvulus		0.0057	0.0865	0.0563
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0056	0.0832	0.1255
Entamoeba histolytica	hypothetical protein	0.0024	0.017	0.0051
Brugia malayi	MH2 domain containing protein	0.0023	0.0149	0.0027
Echinococcus granulosus	snurportin 1	0.0319	0.6377	0.6363
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0056	0.0832	0.0771
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0034	0.0381	0.0346
Brugia malayi	Bm-MIF-1, identical	0.046	0.9324	0.9315
Toxoplasma gondii	ABC1 family protein	0.0034	0.0381	0.028
Toxoplasma gondii	CMGC kinase, MAPK family (ERK) MAPK-1	0.0051	0.0724	0.0653
Brugia malayi	Bromodomain containing protein	0.0035	0.0397	0.0277
Echinococcus multilocularis	musashi	0.0057	0.0865	0.0831
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0071	0.116	0.1128
Brugia malayi	secreted modular calcium-binding protein 1	0.007	0.1134	0.1023
Mycobacterium leprae	conserved hypothetical protein	0.0034	0.0381	0.1479
Loa Loa (eye worm)	macrophage migration inhibitory factor 2	0.0242	0.4757	0.4757
Brugia malayi	MH2 domain containing protein	0.0342	0.6841	0.6801
Brugia malayi	MAP kinase sur-1	0.0051	0.0724	0.0609
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1293	1
Schistosoma mansoni	smad1 5 8 and	0.0023	0.0149	0.0178
Mycobacterium ulcerans	extragenic suppressor protein SuhB	0.0038	0.0466	0.093
Loa Loa (eye worm)	transcription factor SMAD2	0.0342	0.6841	0.6841
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0033	0.0351	0.0316
Brugia malayi	Pre-SET motif family protein	0.0056	0.0832	0.0718
Echinococcus multilocularis	mitogen activated protein kinase 3	0.0051	0.0724	0.069
Echinococcus granulosus	importin subunit beta 1	0.003	0.0289	0.0254
Schistosoma mansoni	hypothetical protein	0.0045	0.0596	0.0883
Plasmodium vivax	importin-beta 2, putative	0.003	0.0289	0.0181
Schistosoma mansoni	serine/threonine protein kinase	0.0051	0.0724	0.1085
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0596	0.0596
Plasmodium falciparum	macrophage migration inhibitory factor	0.046	0.9324	1
Trypanosoma brucei	importin beta-1 subunit, putative	0.003	0.0289	0.2763
Trypanosoma cruzi	myo-inositol-1(or 4)-monophosphatase 1, putative	0.0038	0.0466	0.5704
Loa Loa (eye worm)	hypothetical protein	0.0078	0.1293	0.1293
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0071	0.116	0.1772
Plasmodium vivax	macrophage migration inhibitory factor, putative	0.046	0.9324	1
Loa Loa (eye worm)	CMGC/MAPK/ERK1 protein kinase	0.0051	0.0724	0.0724
Brugia malayi	Pre-SET motif family protein	0.0389	0.7831	0.7804
Echinococcus granulosus	lamin	0.0057	0.0865	0.0831
Trypanosoma cruzi	mitogen activated protein kinase 4, putative	0.0051	0.0724	1
Schistosoma mansoni	lamin	0.0057	0.0865	0.1306
Schistosoma mansoni	inositol monophosphatase	0.0038	0.0466	0.0677
Brugia malayi	follicle stimulating hormone receptor	0.023	0.4497	0.4429
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0033	0.0351	0.0316
Schistosoma mansoni	Smad4	0.0023	0.0149	0.0178
Loa Loa (eye worm)	GTP-binding nuclear protein RAN/TC4	0.0022	0.0123	0.0123
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0381	0.0381
Echinococcus granulosus	cytoplasmic intermediate filament protein	0.0028	0.0241	0.0205
Plasmodium vivax	SET domain protein, putative	0.0056	0.0832	0.0771
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1293	0.1272
Brugia malayi	RNA, U transporter 1	0.0085	0.1449	0.1343
Trichomonas vaginalis	D-aminoacylase, putative	0.0034	0.0381	0.028
Onchocerca volvulus	Huntingtin homolog	0.0133	0.2459	0.2421
Schistosoma mansoni	hypothetical protein	0.0045	0.0596	0.0883
Giardia lamblia	Macrophage migration inhibitory factor	0.046	0.9324	1
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0045	0.0596	0.0562
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0078	0.1293	0.5
Trichomonas vaginalis	macrophage migration inhibitory factor, mif, putative	0.046	0.9324	1
Echinococcus granulosus	GPCR family 2	0.0045	0.0596	0.0562
Echinococcus multilocularis	importin subunit beta 1	0.003	0.0289	0.0254
Trypanosoma cruzi	hypothetical protein, conserved	0.0034	0.0381	0.4292
Loa Loa (eye worm)	thyroglobulin type-1 repeat family protein	0.007	0.1134	0.1134
Brugia malayi	Thyroglobulin type-1 repeat family protein	0.007	0.1134	0.1023
Echinococcus granulosus	lamin dm0	0.0057	0.0865	0.0831
Loa Loa (eye worm)	hypothetical protein	0.0034	0.0381	0.0381
Schistosoma mansoni	peptidase Clp (S14 family)	0.0078	0.1293	0.1982
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0071	0.116	0.1772
Brugia malayi	hypothetical protein	0.0133	0.2459	0.2364
Echinococcus granulosus	TGF beta signal transducer SmadC	0.0023	0.0149	0.0113
Onchocerca volvulus		0.007	0.1134	0.0877
Toxoplasma gondii	macrophage migration inhibitory factor, putative	0.046	0.9324	1
Loa Loa (eye worm)	MH2 domain-containing protein	0.0342	0.6841	0.6841
Leishmania major	importin beta-1 subunit, putative	0.0024	0.017	0.0051
Echinococcus multilocularis	mothers against decapentaplegic 5	0.0023	0.0149	0.0113
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0027	0.0223	0.0108
Echinococcus multilocularis	survival motor neuron protein 1	0.0492	1	1

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 21 uM	Inhibitory activity against fibroblast growth factor receptor (FGFr)	ChEMBL.	No reference
IC50 (binding)	= 21 uM	Inhibitory activity against fibroblast growth factor receptor (FGFr)	ChEMBL.	No reference
Inhibition (binding)	= 16 %	Inhibitory activity against c-src tyrosine kinase at 50 uM	ChEMBL.	No reference
Inhibition (binding)	= 16 %	Inhibitory activity against c-src tyrosine kinase at 50 uM	ChEMBL.	No reference
Inhibition (binding)	= 24 %	Inhibitory activity against platelet-derived growth factor receptor (PDGFr) at 50 uM	ChEMBL.	No reference
Inhibition (binding)	= 24 %	Inhibitory activity against platelet-derived growth factor receptor (PDGFr) at 50 uM	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL99352

Bibliographic References

No literature references available for this target.

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Detailed information for compound 161899