Detailed information for compound 1628589

Basic information

Technical information
  • TDR Targets ID: 1628589
  • Name: 2-(butylaminomethylidene)-5-phenylcyclohexane -1,3-dione
  • MW: 271.354 | Formula: C17H21NO2
  • H donors: 1 H acceptors: 2 LogP: 3.44 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN/C=C/1\C(=O)CC(CC1=O)c1ccccc1
  • InChi: 1S/C17H21NO2/c1-2-3-9-18-12-15-16(19)10-14(11-17(15)20)13-7-5-4-6-8-13/h4-8,12,14,18H,2-3,9-11H2,1H3/b15-12-
  • InChiKey: BPGODBBZKGTBDY-QINSGFPZSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(butylaminomethylene)-5-phenyl-cyclohexane-1,3-dione
  • 2-(butylaminomethylene)-5-phenylcyclohexane-1,3-dione
  • 2-(butylaminomethylene)-5-phenyl-cyclohexane-1,3-quinone
  • 2-(butylaminomethylidene)-5-phenyl-cyclohexane-1,3-dione
  • AK-968/13659122
  • STK158366
  • 2-[(butylamino)methylene]-5-phenyl-1,3-cyclohexanedione
  • MLS000681319
  • SMR000267712

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) MH2 domain-containing protein 0.0008 0.002 0.0036
Entamoeba histolytica hypothetical protein 0.0043 0.0288 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0759 0.567 0.567
Brugia malayi hypothetical protein 0.005 0.0336 0.0592
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0669 0.0669
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0035 0.0035
Trichomonas vaginalis importin beta-1, putative 0.0024 0.014 0.0649
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0528 0.0528
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0279 0.1307
Brugia malayi kinase, mitochondrial precursor 0.0759 0.567 1
Schistosoma mansoni Smad4 0.0008 0.002 0.002
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.005 0.0336 0.0592
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.005 0.0336 0.0336
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0035 0.0035
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0008 0.002 0.002
Echinococcus granulosus somatostatin receptor 0.005 0.0336 0.0336
Schistosoma mansoni importin beta-1 0.0029 0.0181 0.0181
Loa Loa (eye worm) CYP4Cod1 0.0012 0.0054 0.0095
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0035 0.0061
Leishmania major heat shock protein 83-1 0.0042 0.0279 0.0487
Plasmodium vivax DNA topoisomerase II, putative 0.0042 0.0279 0.5253
Entamoeba histolytica DNA topoisomerase II, putative 0.0042 0.0279 0.9674
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0035 0.0061
Onchocerca volvulus 0.005 0.0336 0.1448
Onchocerca volvulus 0.005 0.0336 0.1448
Onchocerca volvulus 0.0075 0.0528 0.2373
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Schistosoma mansoni biogenic amine receptor 0.005 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0528 0.0931
Echinococcus granulosus mothers against decapentaplegic 5 0.0008 0.002 0.002
Echinococcus multilocularis g protein coupled receptor 0.005 0.0336 0.0336
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0528 0.2489
Trichomonas vaginalis DNA topoisomerase II, putative 0.0042 0.0279 0.1307
Leishmania major GTP-binding protein, putative 0.0022 0.0123 0.0212
Brugia malayi TAR-binding protein 0.0195 0.1427 0.2516
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.005 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0075 0.0528 0.0931
Trypanosoma brucei heat shock protein 90, putative 0.0042 0.0279 0.0487
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.005 0.0336 0.0336
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.005 0.0336 0.0336
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.005 0.0336 0.0592
Schistosoma mansoni hypothetical protein 0.0078 0.0549 0.0549
Schistosoma mansoni smad 0.0008 0.002 0.002
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.0033 0.1111
Trichomonas vaginalis DNA helicase recq, putative 0.0023 0.0136 0.0632
Schistosoma mansoni hypothetical protein 0.005 0.0336 0.0336
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0035 0.0035
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0042 0.0279 0.4739
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0528 0.2489
Schistosoma mansoni tar DNA-binding protein 0.0195 0.1427 0.1427
Onchocerca volvulus 0.005 0.0336 0.1448
Leishmania major heat shock protein 83-1 0.0042 0.0279 0.0487
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0832 0.1467
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0042 0.0279 0.4739
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.005 0.0336 0.0592
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0042 0.0279 0.5
Loa Loa (eye worm) hypothetical protein 0.0078 0.0549 0.0968
Schistosoma mansoni tar DNA-binding protein 0.0195 0.1427 0.1427
Echinococcus multilocularis bloom syndrome protein 0.0023 0.0136 0.0136
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.008 0.1462
Echinococcus granulosus FTZ F1 alpha 0.001 0.0035 0.0035
Echinococcus granulosus orexin receptor type 2 0.005 0.0336 0.0336
Brugia malayi steroid hormone receptor 0.001 0.0035 0.0061
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0528 0.0755
Brugia malayi MH2 domain containing protein 0.0008 0.002 0.0036
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0832 0.1467
Brugia malayi Cytochrome P450 family protein 0.0012 0.0054 0.0095
Brugia malayi Serotonin/octopamine receptor family protein 7 0.005 0.0336 0.0592
Loa Loa (eye worm) hypothetical protein 0.0169 0.123 0.217
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0042 0.0279 0.04
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0078 0.0549 0.0968
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0033 0.0059
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0123 0.3661
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0336 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0035 0.0061
Echinococcus multilocularis fmrfamide receptor 0.005 0.0336 0.0336
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0307 0.2275 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0288 0.0288
Onchocerca volvulus 0.0286 0.2113 1
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0035 0.0035
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.005 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0061
Brugia malayi hypothetical protein 0.005 0.0336 0.0592
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Loa Loa (eye worm) hypothetical protein 0.0075 0.0528 0.0931
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0042 0.0279 0.0492
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0222 0.0222
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0528 0.0755
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.0033 0.0033
Leishmania major heat shock protein 83-1 0.0042 0.0279 0.0487
Echinococcus multilocularis neuropeptide s receptor 0.005 0.0336 0.0336
Brugia malayi kap beta 3 protein 0.0006 0.0003 0.0005
Trichomonas vaginalis esterase, putative 0.0075 0.0528 0.2489
Brugia malayi G-protein coupled receptor 0.005 0.0336 0.0592
Leishmania major heat shock protein 83-1 0.0042 0.0279 0.0487
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0122 0.0878 0.0878
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.005 0.0336 0.0336
Entamoeba histolytica hypothetical protein 0.0024 0.014 0.48
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0035 0.0035
Schistosoma mansoni endoplasmin 0.0042 0.0279 0.0279
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0528 0.0528
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.1852 0.3266
Schistosoma mansoni hypothetical protein 0.0169 0.123 0.123
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0042 0.0279 0.04
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0759 0.567 0.567
Echinococcus granulosus microtubule associated protein 2 0.0668 0.4986 0.4986
Chlamydia trachomatis DNA gyrase subunit B 0.0042 0.0279 0.5
Echinococcus granulosus g protein coupled receptor 0.005 0.0336 0.0336
Echinococcus multilocularis Smad4 0.0008 0.002 0.002
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0528 0.2489
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0035 0.0061
Echinococcus granulosus g protein coupled receptor 0.005 0.0336 0.0336
Schistosoma mansoni hypothetical protein 0.0164 0.1197 0.1197
Loa Loa (eye worm) neuropeptide F receptor 0.005 0.0336 0.0592
Schistosoma mansoni neuropeptide f receptor 76f 0.005 0.0336 0.0336
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0288 0.0288
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0042 0.0279 0.5
Schistosoma mansoni amine GPCR 0.005 0.0336 0.0336
Echinococcus multilocularis GPCR, family 2 0.0078 0.0549 0.0549
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0336 0.0336
Schistosoma mansoni biogenic amine (dopamine) receptor 0.005 0.0336 0.0336
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0035 0.0061
Plasmodium falciparum DNA gyrase subunit B 0.0042 0.0279 1
Trichomonas vaginalis DNA helicase recq1, putative 0.0023 0.0136 0.0632
Trypanosoma cruzi heat shock protein 85, putative 0.0042 0.0279 0.04
Schistosoma mansoni tar DNA-binding protein 0.0195 0.1427 0.1427
Echinococcus multilocularis neuropeptide receptor A26 0.005 0.0336 0.0336
Schistosoma mansoni myosin xvIII 0.005 0.0336 0.0336
Entamoeba histolytica hypothetical protein 0.0043 0.0288 1
Leishmania major heat shock protein 83-1 0.0042 0.0279 0.0487
Entamoeba histolytica hypothetical protein 0.0043 0.0288 1
Brugia malayi MH1 domain containing protein 0.0008 0.002 0.0036
Plasmodium falciparum importin beta, putative 0.0029 0.0181 0.6472
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0759 0.567 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0061
Schistosoma mansoni coup transcription factor 0.001 0.0035 0.0035
Loa Loa (eye worm) follicle stimulating hormone receptor 0.005 0.0336 0.0592
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0033 0.0135
Brugia malayi nuclear hormone receptor 0.001 0.0035 0.0061
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0035 0.0035
Echinococcus granulosus fmrfamide receptor 0.005 0.0336 0.0336
Brugia malayi G protein-coupled receptor 0.005 0.0336 0.0592
Trypanosoma cruzi heat shock protein 85, putative 0.0042 0.0279 0.04
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.005 0.0336 0.0592
Echinococcus granulosus biogenic amine 5HT receptor 0.005 0.0336 0.0336
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0035 0.0035
Leishmania major hypothetical protein, conserved 0.0042 0.0279 0.0487
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Trypanosoma brucei heat shock protein, putative 0.0042 0.0279 0.0487
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Echinococcus multilocularis importin 5 0.0006 0.0003 0.0003
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0528 0.0528
Onchocerca volvulus 0.005 0.0336 0.1448
Echinococcus multilocularis heat shock protein 90 0.0042 0.0279 0.0279
Plasmodium vivax hypothetical protein, conserved 0.0042 0.0279 0.5253
Trypanosoma cruzi heat shock protein 90, putative 0.0042 0.0279 0.04
Brugia malayi Probable DNA topoisomerase II 0.0042 0.0279 0.0492
Schistosoma mansoni neuropeptide F-like receptor 0.005 0.0336 0.0336
Echinococcus granulosus neuropeptide receptor 0.005 0.0336 0.0336
Leishmania major heat shock protein 83-1 0.0042 0.0279 0.0487
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0528 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.005 0.0336 0.0336
Echinococcus granulosus GPCR family 2 0.0078 0.0549 0.0549
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0336 0.0336
Trypanosoma brucei developmentally regulated phosphoprotein 0.0759 0.567 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0035 0.0035
Echinococcus granulosus neuropeptides capa receptor 0.005 0.0336 0.0336
Brugia malayi ORL1-like opioid receptor 0.005 0.0336 0.0592
Loa Loa (eye worm) hypothetical protein 0.0247 0.1818 0.3206
Loa Loa (eye worm) G-protein coupled receptor 0.005 0.0336 0.0592
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.005 0.0336 0.1448
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.005 0.0336 0.0336
Mycobacterium tuberculosis Conserved protein 0.0075 0.0528 0.0755
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0042 0.0279 0.5
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0232 0.0232
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0035 0.0061
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0042 0.0279 0.1307
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Echinococcus granulosus 7TM GPCR rhodopsin 0.005 0.0336 0.0336
Echinococcus granulosus importin 5 0.0006 0.0003 0.0003
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0123 0.0123
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0181 0.0181
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0669 0.0669
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0035 0.0061
Trypanosoma brucei heat shock protein, putative 0.0042 0.0279 0.0487
Schistosoma mansoni heat shock protein 0.0042 0.0279 0.0279
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0035 0.0061
Loa Loa (eye worm) neuropeptide F receptor 0.005 0.0336 0.0592
Trypanosoma brucei cytochrome P450, putative 0.0012 0.0054 0.0091
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Brugia malayi follicle stimulating hormone receptor 0.005 0.0336 0.0592
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0336 0.0336
Schistosoma mansoni pyruvate dehydrogenase 0.0759 0.567 0.567
Chlamydia trachomatis DNA gyrase subunit B 0.0042 0.0279 0.5
Brugia malayi MH1 domain containing protein 0.0008 0.002 0.0036
Brugia malayi RNA, U transporter 1 0.0083 0.0587 0.1036
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.005 0.0336 0.0336
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.005 0.0336 0.0592
Loa Loa (eye worm) kap beta 3 protein 0.0006 0.0003 0.0005
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0035 0.0061
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Schistosoma mansoni hypothetical protein 0.0047 0.0312 0.0312
Loa Loa (eye worm) hypothetical protein 0.0075 0.0528 0.0931
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.005 0.0336 0.0336
Onchocerca volvulus 0.005 0.0336 0.1448
Schistosoma mansoni hypothetical protein 0.005 0.0336 0.0336
Schistosoma mansoni neuropeptide receptor 0.1334 1 1
Brugia malayi neuropeptide F receptor 0.005 0.0336 0.0592
Echinococcus granulosus neuropeptide s receptor 0.005 0.0336 0.0336
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Echinococcus granulosus TGF beta signal transducer SmadC 0.0008 0.002 0.002
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Trichomonas vaginalis endoplasmin, putative 0.0042 0.0279 0.1307
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Echinococcus multilocularis dro:myosuppressin receptor 0.005 0.0336 0.0336
Leishmania major heat shock protein 83-1 0.0042 0.0279 0.0487
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0042 0.0279 0.0492
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0035 0.0035
Brugia malayi Serotonin receptor 0.005 0.0336 0.0592
Loa Loa (eye worm) endoplasmin 0.0042 0.0279 0.0492
Mycobacterium ulcerans two component regulator - sensor kinase 0.0042 0.0279 0.4739
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Loa Loa (eye worm) TAR-binding protein 0.0195 0.1427 0.2516
Schistosoma mansoni blooms syndrome DNA helicase 0.0018 0.0099 0.0099
Entamoeba histolytica recQ family helicase, putative 0.0012 0.0055 0.182
Leishmania major heat shock protein 83-1 0.0042 0.0279 0.0487
Echinococcus multilocularis somatostatin receptor 0.005 0.0336 0.0336
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0042 0.0279 0.1174
Mycobacterium leprae Probable lipase LipE 0.0075 0.0528 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0123 0.053
Leishmania major importin beta-1 subunit, putative 0.0024 0.014 0.0242
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0232 0.0232
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0042 0.0279 0.0279
Echinococcus multilocularis neuropeptide Y receptor 0.005 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.005 0.0336 0.0336
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0247 0.1818 0.3206
Loa Loa (eye worm) RecQ helicase 0.0023 0.0136 0.024
Echinococcus granulosus geminin 0.0164 0.1197 0.1197
Schistosoma mansoni biogenic amine receptor 0.005 0.0336 0.0336
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0123 0.0212
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0123 0.0217
Loa Loa (eye worm) TYRA-2 protein 0.005 0.0336 0.0592
Trypanosoma cruzi Heat shock protein 83, putative 0.0042 0.0279 0.04
Schistosoma mansoni microtubule-associated protein tau 0.0668 0.4986 0.4986
Schistosoma mansoni peptide (allatostatin)-like receptor 0.005 0.0336 0.0336
Brugia malayi Pre-SET motif family protein 0.0036 0.0232 0.041
Loa Loa (eye worm) hypothetical protein 0.0042 0.0279 0.0492
Loa Loa (eye worm) hypothetical protein 0.0075 0.0528 0.0931
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0528 1
Loa Loa (eye worm) hypothetical protein 0.0229 0.1683 0.2968
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0035 0.0061
Plasmodium falciparum DNA topoisomerase 2 0.0042 0.0279 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Echinococcus granulosus Smad4 0.0008 0.002 0.002
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0061
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0061
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0265 0.1957 0.8602
Schistosoma mansoni growth hormone secretagogue receptor 0.005 0.0336 0.0336
Brugia malayi nuclear receptor NHR-88 0.001 0.0035 0.0061
Trypanosoma brucei heat shock protein, putative 0.0042 0.0279 0.0487
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.0033 0.0033
Onchocerca volvulus 0.005 0.0336 0.1448
Toxoplasma gondii heat shock protein HSP90 0.0042 0.0279 0.1215
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0336 0.0336
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0336 0.0336
Onchocerca volvulus 0.005 0.0336 0.1448
Echinococcus multilocularis neuropeptide Y receptor 0.005 0.0336 0.0336
Brugia malayi hypothetical protein 0.005 0.0336 0.0592
Brugia malayi AKH receptor 0.005 0.0336 0.0592
Mycobacterium ulcerans two component sensor kinase MprB 0.0042 0.0279 0.4739
Brugia malayi G-protein coupled receptor 0.005 0.0336 0.0592
Schistosoma mansoni DNA helicase recq1 0.001 0.0033 0.0033
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0336 0.0336
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0042 0.0279 0.5
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Brugia malayi RNA binding protein 0.0195 0.1427 0.2516
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0336 0.0336
Mycobacterium ulcerans DNA gyrase subunit B 0.0042 0.0279 0.4739
Brugia malayi hypothetical protein 0.0229 0.1683 0.2968
Schistosoma mansoni hypothetical protein 0.0078 0.0549 0.0549
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.005 0.0336 0.0336
Schistosoma mansoni biogenic amine (dopamine) receptor 0.005 0.0336 0.0336
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.005 0.0336 0.0336
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0042 0.0279 0.1307
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0232 0.0232
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0042 0.0279 0.4739
Schistosoma mansoni tar DNA-binding protein 0.0195 0.1427 0.1427
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0035 0.0035
Loa Loa (eye worm) heat shock protein 90 0.0042 0.0279 0.0492
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0035 0.0061
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.005 0.0336 0.0336
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0336 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0035 0.0061
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0061
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0759 0.567 0.567
Onchocerca volvulus 0.005 0.0336 0.1448
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0035 0.0061
Echinococcus granulosus dro:myosuppressin receptor 0.005 0.0336 0.0336
Onchocerca volvulus 0.0075 0.0528 0.2373
Plasmodium vivax SET domain protein, putative 0.0036 0.0232 0.4371
Schistosoma mansoni nuclear hormone receptor 0.001 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0122 0.0878 0.0878
Leishmania major DNA topoisomerase ii 0.0042 0.0279 0.0487
Trypanosoma brucei heat shock protein, putative 0.0042 0.0279 0.0487
Schistosoma mansoni heat shock protein 0.0042 0.0279 0.0279
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Entamoeba histolytica hypothetical protein 0.0043 0.0288 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Echinococcus granulosus thyrotropin releasing hormone receptor 0.005 0.0336 0.0336
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0232 0.0232
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.005 0.0336 0.0336
Brugia malayi Dopamine receptor 0.005 0.0336 0.0592
Echinococcus granulosus G protein coupled receptor 139 0.005 0.0336 0.0336
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0094 0.0669 0.118
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0312 0.0551
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0232 0.0232
Echinococcus granulosus neuropeptide Y receptor 0.005 0.0336 0.0336
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.014 0.0649
Echinococcus multilocularis heat shock protein 0.0042 0.0279 0.0279
Leishmania major heat shock protein 83-1 0.0042 0.0279 0.0487
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.002 0.0115 0.4067
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.014 0.0152
Onchocerca volvulus 0.005 0.0336 0.1448
Echinococcus multilocularis g protein coupled receptor 0.005 0.0336 0.0336
Brugia malayi hypothetical protein 0.005 0.0336 0.0592
Brugia malayi GnHR receptor homolog 0.005 0.0336 0.0592
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.0033 0.0059
Onchocerca volvulus Neuropeptide F receptor homolog 0.005 0.0336 0.1448
Schistosoma mansoni endoplasmin 0.0042 0.0279 0.0279
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0035 0.0035
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0528 0.0931
Schistosoma mansoni neuropeptide F-like receptor 0.005 0.0336 0.0336
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0336 0.0336
Loa Loa (eye worm) RNA binding protein 0.0195 0.1427 0.2516
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0055 0.0001
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0336 0.0336
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0669 0.0669
Echinococcus granulosus neuropeptide receptor A26 0.005 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0336 0.0336
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0042 0.0279 0.1307
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0035 0.0035
Schistosoma mansoni hypothetical protein 0.0164 0.1197 0.1197
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0528 0.2489
Schistosoma mansoni biogenic amine (dopamine) receptor 0.005 0.0336 0.0336
Trypanosoma cruzi heat shock protein 85, putative 0.0042 0.0279 0.04
Leishmania major heat shock protein 83-1 0.0042 0.0279 0.0487
Brugia malayi larval opioid receptor 0.005 0.0336 0.0592
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0042 0.0279 0.1174
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0094 0.0669 0.118
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.005 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Brugia malayi hypothetical protein 0.0043 0.0288 0.0508
Brugia malayi ecdysteroid receptor 0.001 0.0035 0.0061
Brugia malayi hypothetical protein 0.005 0.0336 0.0592
Onchocerca volvulus 0.005 0.0336 0.1448
Echinococcus granulosus transportin 1 0.0006 0.0003 0.0003
Echinococcus granulosus importin subunit beta 1 0.0029 0.0181 0.0181
Brugia malayi gonadotropin-releasing hormone receptor 2 0.005 0.0336 0.0592
Echinococcus granulosus tachykinin peptides receptor 99D 0.005 0.0336 0.0336
Toxoplasma gondii heat shock protein 90, putative 0.0042 0.0279 0.1215
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0035 0.0061
Echinococcus multilocularis alpha 1A adrenergic receptor 0.005 0.0336 0.0336
Echinococcus multilocularis thyroid hormone receptor alpha 0.0132 0.0951 0.0951
Schistosoma mansoni opsin-like receptor 0.005 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0036 0.0232 0.041
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0055 0.0092
Trichomonas vaginalis receptor histidine kinase, putative 0.0042 0.0279 0.1307
Echinococcus multilocularis fmrfamide receptor 0.005 0.0336 0.0336
Echinococcus granulosus g protein coupled receptor 0.005 0.0336 0.0336
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0265 0.1957 0.3448
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0528 0.0755
Echinococcus granulosus peptide allatostatin:somatostatin 0.005 0.0336 0.0336
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0669 0.0669
Echinococcus multilocularis orexin receptor type 2 0.005 0.0336 0.0336
Schistosoma mansoni hypothetical protein 0.0078 0.0549 0.0549
Toxoplasma gondii ABC1 family protein 0.0075 0.0528 0.2312
Schistosoma mansoni ran 0.0022 0.0123 0.0123
Loa Loa (eye worm) G-protein coupled receptor 0.005 0.0336 0.0592
Loa Loa (eye worm) latrophilin receptor protein 2 0.0078 0.0549 0.0968
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.005 0.0336 0.0336
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0042 0.0279 0.04
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0042 0.0279 0.1307
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0123 0.0217
Echinococcus multilocularis neuropeptides capa receptor 0.005 0.0336 0.0336
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0528 0.0755
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0528 0.2489
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0247 0.1818 0.3206
Trypanosoma brucei heat shock protein, putative 0.0042 0.0279 0.0487
Onchocerca volvulus 0.005 0.0336 0.1448
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0528 0.0844
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0035 0.0061
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.005 0.0336 0.0336
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0042 0.0279 0.1215
Schistosoma mansoni ran 0.0022 0.0123 0.0123
Onchocerca volvulus 0.005 0.0336 0.1448
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0078 0.0549 0.0549
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0035 0.0035
Echinococcus granulosus g-protein coupled receptor 0.005 0.0336 0.0336
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0035 0.0035
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0528 0.0528
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0042 0.0279 0.5
Schistosoma mansoni opsin-like receptor 0.005 0.0336 0.0336
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.0033 0.0033
Loa Loa (eye worm) hypothetical protein 0.0042 0.0279 0.0492
Brugia malayi hypothetical protein 0.005 0.0336 0.0592
Schistosoma mansoni alpha-1 adrenergic receptor 0.005 0.0336 0.0336
Trypanosoma brucei heat shock protein 90, putative 0.0042 0.0279 0.0487
Leishmania major heat shock protein 83-1 0.0042 0.0279 0.0487
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0528 0.0755
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0042 0.0279 0.4739
Loa Loa (eye worm) importin-beta domain-containing protein 0.0006 0.0003 0.0005
Schistosoma mansoni amine GPCR 0.005 0.0336 0.0336
Brugia malayi Tachykinin-like peptides receptor 99D 0.005 0.0336 0.0592
Leishmania major heat shock protein 83-1 0.0042 0.0279 0.0487
Schistosoma mansoni biogenic amine receptor 0.005 0.0336 0.0336
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0035 0.0061
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0232 0.1011
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0094 0.0669 0.0669
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.005 0.0336 0.0336
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0035 0.0061
Leishmania major cytochrome p450-like protein 0.0012 0.0054 0.0091
Loa Loa (eye worm) hypothetical protein 0.0075 0.0528 0.0931
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0035 0.0035
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.005 0.0336 0.0336
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.005 0.0336 0.0336
Echinococcus multilocularis snurportin 1 0.0312 0.2312 0.2312
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0035 0.0061
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0336 0.0336
Schistosoma mansoni hypothetical protein 0.0043 0.0288 0.0288
Echinococcus multilocularis sex peptide receptor 0.005 0.0336 0.0336
Echinococcus multilocularis tachykinin peptides receptor 99D 0.005 0.0336 0.0336
Brugia malayi Cytochrome P450 family protein 0.0012 0.0054 0.0095
Onchocerca volvulus 0.005 0.0336 0.1448
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0336 0.0336
Echinococcus multilocularis g protein coupled receptor 0.005 0.0336 0.0336
Echinococcus multilocularis g-protein coupled receptor 0.005 0.0336 0.0336
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0042 0.0279 0.1307
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0042 0.0279 1
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0181 0.0315
Brugia malayi MH2 domain containing protein 0.0116 0.0832 0.1467
Schistosoma mansoni tar DNA-binding protein 0.0195 0.1427 0.1427
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0035 0.0061
Echinococcus granulosus neuropeptide Y receptor 0.005 0.0336 0.0336
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0042 0.0279 0.0487
Loa Loa (eye worm) hypothetical protein 0.001 0.0033 0.0059
Leishmania major heat shock protein 83-1 0.0042 0.0279 0.0487
Echinococcus granulosus neuropeptides capa receptor 0.005 0.0336 0.0336
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.005 0.0336 0.0336
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0336 0.0336
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0265 0.1957 0.3388
Schistosoma mansoni thyroid hormone receptor 0.0132 0.0951 0.0951
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.005 0.0336 0.0336
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0035 0.0035
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0123 0.0123
Trypanosoma cruzi DNA topoisomerase II, putative 0.0042 0.0279 0.04
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0035 0.0035
Echinococcus granulosus tm gpcr rhodopsin 0.005 0.0336 0.0336
Echinococcus multilocularis geminin 0.0164 0.1197 0.1197
Echinococcus granulosus translational activator gcn1 0.0006 0.0003 0.0003
Brugia malayi Dopamine receptor protein 1 0.005 0.0336 0.0592
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.005 0.0336 0.0336
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0035 0.0035
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0035 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0035 0.0061
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0035 0.0035
Onchocerca volvulus 0.005 0.0336 0.1448
Echinococcus multilocularis biogenic amine (5HT) receptor 0.005 0.0336 0.0336
Echinococcus multilocularis microtubule associated protein 2 0.0668 0.4986 0.4986
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0232 0.0232
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0042 0.0279 0.5
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0042 0.0279 0.4739
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Trypanosoma brucei heat shock protein, putative 0.0042 0.0279 0.0487
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.0078 0.0332
Loa Loa (eye worm) hypothetical protein 0.0117 0.0843 0.1486
Brugia malayi Latrophilin receptor protein 2 0.0078 0.0549 0.0968
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0042 0.0279 0.0279
Onchocerca volvulus 0.0075 0.0528 0.2373
Brugia malayi Importin beta-1 subunit 0.0029 0.0181 0.032
Schistosoma mansoni histamine h1 receptor 0.005 0.0336 0.0336
Schistosoma mansoni biogenic amine (5HT) receptor 0.005 0.0336 0.0336
Schistosoma mansoni adenoreceptor 0.005 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Brugia malayi beta-lactamase family protein 0.0075 0.0528 0.0931
Loa Loa (eye worm) hypothetical protein 0.0029 0.0181 0.032
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0265 0.1957 0.3448
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0123 0.2293
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0042 0.0279 0.0487
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.1683 0.1683
Schistosoma mansoni survival motor neuron protein 0.0047 0.0312 0.0312
Loa Loa (eye worm) Smad1 0.0008 0.002 0.0036
Giardia lamblia Pms1-like protein 0.0042 0.0279 1
Entamoeba histolytica heat shock protein 90, putative 0.0042 0.0279 0.9674
Echinococcus granulosus biogenic amine 5HT receptor 0.005 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0061
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0012 0.0055 0.0092
Leishmania major heat shock protein 83-1 0.0042 0.0279 0.0487
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.005 0.0336 0.0592
Mycobacterium ulcerans putative regultory protein 0.0042 0.0279 0.4739
Toxoplasma gondii DNA topoisomerase 2, putative 0.0042 0.0279 0.1215
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0288 0.0288
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.0033 0.0135
Echinococcus granulosus serotonin receptor 0.005 0.0336 0.0336
Schistosoma mansoni DNA topoisomerase II 0.0042 0.0279 0.0279
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0123 0.4365
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0528 0.0755
Schistosoma mansoni opsin-like receptor 0.005 0.0336 0.0336
Echinococcus granulosus tm gpcr rhodopsin 0.005 0.0336 0.0336
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.005 0.0336 0.0592
Brugia malayi Dopamine receptor protein 2 0.005 0.0336 0.0592
Echinococcus granulosus snurportin 1 0.0312 0.2312 0.2312
Onchocerca volvulus 0.005 0.0336 0.1448
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0336 0.0336
Leishmania major heat shock protein 83-1 0.0042 0.0279 0.0487
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0078 0.0549 0.0549
Schistosoma mansoni hypothetical protein 0.0078 0.0549 0.0549
Echinococcus multilocularis neuropeptides capa receptor 0.005 0.0336 0.0336
Onchocerca volvulus 0.005 0.0336 0.1448
Trypanosoma brucei DNA topoisomerase ii 0.0042 0.0279 0.0487
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0061
Schistosoma mansoni amine GPCR 0.005 0.0336 0.0336
Plasmodium vivax heat shock protein 86, putative 0.0042 0.0279 0.5253
Echinococcus multilocularis tar DNA binding protein 0.0195 0.1427 0.1427
Mycobacterium ulcerans lipase LipD 0.0075 0.0528 1
Brugia malayi sulfakinin receptor protein 0.005 0.0336 0.0592
Loa Loa (eye worm) melatonin receptor type 1A 0.005 0.0336 0.0592
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0336 0.0336
Brugia malayi putative neuropeptide receptor 0.005 0.0336 0.0592
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0528 0.0755
Trichomonas vaginalis set domain proteins, putative 0.0286 0.2113 1
Trichomonas vaginalis sensor histidine kinase, putative 0.0042 0.0279 0.1307
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.0759 0.567 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0054 0.0095
Brugia malayi Melatonin receptor type 1A 0.005 0.0336 0.0592
Onchocerca volvulus 0.005 0.0336 0.1448
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0008 0.002 0.002
Brugia malayi Endoplasmin precursor 0.0042 0.0279 0.0492
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0035 0.0061
Loa Loa (eye worm) TOPoisomerase family member 0.0042 0.0279 0.0492
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.005 0.0336 0.0336
Trichomonas vaginalis heat shock protein, putative 0.0042 0.0279 0.1307
Giardia lamblia Heat shock protein HSP 90-alpha 0.0042 0.0279 1
Schistosoma mansoni pyruvate dehydrogenase 0.0717 0.5353 0.5353
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Schistosoma mansoni biogenic amine (5HT) receptor 0.005 0.0336 0.0336
Brugia malayi latrophilin 2 splice variant baaae 0.0169 0.123 0.217
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0078 0.0549 0.0549
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0035 0.0035
Loa Loa (eye worm) cytochrome P450 family protein 0.0012 0.0054 0.0095
Schistosoma mansoni hypothetical protein 0.0312 0.2312 0.2312
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0481 0.3583 1
Echinococcus multilocularis allatostatin A receptor 0.005 0.0336 0.0336
Trypanosoma brucei Heat shock protein 83, putative 0.0042 0.0279 0.0487
Schistosoma mansoni amine GPCR 0.005 0.0336 0.0336
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0336 0.0336
Echinococcus multilocularis smad 0.0008 0.002 0.002
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0042 0.0279 0.1215
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0123 0.0123
Schistosoma mansoni neuropeptide receptor 0.005 0.0336 0.0336
Schistosoma mansoni smad1 5 8 and 0.0008 0.002 0.002
Brugia malayi hypothetical protein 0.005 0.0336 0.0592
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0336 0.0336
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0042 0.0279 0.4739
Echinococcus multilocularis neuropeptide receptor 0.005 0.0336 0.0336
Brugia malayi beta-lactamase family protein 0.0075 0.0528 0.0931
Schistosoma mansoni hypothetical protein 0.005 0.0336 0.0336
Schistosoma mansoni hypothetical protein 0.005 0.0336 0.0336
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0042 0.0279 0.1174
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Trichomonas vaginalis DNA helicase recq, putative 0.0012 0.0055 0.0246
Echinococcus granulosus tm gpcr rhodopsin 0.005 0.0336 0.0336
Leishmania major hypothetical protein, conserved 0.0075 0.0528 0.0927
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Brugia malayi Pre-SET motif family protein 0.0251 0.1852 0.3266
Leishmania major heat shock protein 83-1 0.0042 0.0279 0.0487
Brugia malayi Smad1 0.0008 0.002 0.0036
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Onchocerca volvulus 0.0047 0.0312 0.1336
Brugia malayi RNA recognition motif domain containing protein 0.0195 0.1427 0.2516
Schistosoma mansoni amine GPCR 0.005 0.0336 0.0336
Echinococcus granulosus bloom syndrome protein 0.0023 0.0136 0.0136
Brugia malayi neuropeptide F receptor 0.005 0.0336 0.0592
Echinococcus granulosus 7tm_1 domain containing protein 0.005 0.0336 0.0336
Schistosoma mansoni neuropeptide receptor 0.005 0.0336 0.0336
Echinococcus granulosus alpha 1A adrenergic receptor 0.005 0.0336 0.0336
Brugia malayi putative neuropeptide receptor NPR1 0.005 0.0336 0.0592
Echinococcus granulosus allatostatin A receptor 0.005 0.0336 0.0336
Schistosoma mansoni importin-beta 2 0.0006 0.0003 0.0003
Loa Loa (eye worm) hypothetical protein 0.001 0.0035 0.0061
Trichomonas vaginalis ran, putative 0.0022 0.0123 0.0571
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0528 1
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0122 0.0878 0.0878
Echinococcus multilocularis serotonin receptor 0.005 0.0336 0.0336
Echinococcus multilocularis translational activator gcn1 0.0006 0.0003 0.0003
Trypanosoma cruzi heat shock protein 90, putative 0.0042 0.0279 0.04
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0035 0.0061
Echinococcus multilocularis neuropeptide FF receptor 2 0.005 0.0336 0.0336
Mycobacterium tuberculosis Conserved protein 0.0075 0.0528 0.0755
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0035 0.0061
Echinococcus granulosus tar DNA binding protein 0.0195 0.1427 0.1427
Brugia malayi hypothetical protein 0.005 0.0336 0.0592
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Brugia malayi hypothetical protein 0.005 0.0336 0.0592
Trypanosoma brucei heat shock protein, putative 0.0042 0.0279 0.0487
Trypanosoma brucei heat shock protein, putative 0.0042 0.0279 0.0487
Echinococcus multilocularis mothers against decapentaplegic 5 0.0008 0.002 0.002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0094 0.0669 0.0669
Plasmodium vivax endoplasmin, putative 0.0042 0.0279 0.5253
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0042 0.0279 0.4739
Schistosoma mansoni smad1 5 8 and 0.0008 0.002 0.002
Echinococcus granulosus heat shock protein 0.0042 0.0279 0.0279
Plasmodium falciparum heat shock protein 90 0.0042 0.0279 1
Brugia malayi Serotonin receptor 0.005 0.0336 0.0592
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0528 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.005 0.0336 0.0336
Echinococcus multilocularis serotonin receptor 0.005 0.0336 0.0336
Echinococcus granulosus sex peptide receptor 0.005 0.0336 0.0336
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Leishmania major developmentally regulated phosphoprotein-like protein 0.0759 0.567 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Plasmodium vivax DNA gyrase subunit B, putative 0.0042 0.0279 0.5253
Entamoeba histolytica heat shock protein 90, putative 0.0042 0.0279 0.9674
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.0033 0.0033
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0232 0.0232
Onchocerca volvulus 0.0036 0.0232 0.0951
Brugia malayi MH2 domain containing protein 0.0008 0.002 0.0036
Schistosoma mansoni thyroid hormone receptor 0.0132 0.0951 0.0951
Echinococcus multilocularis neuropeptide receptor 0.1334 1 1
Mycobacterium tuberculosis Conserved protein 0.0075 0.0528 0.0755
Leishmania major heat shock protein 83-1 0.0042 0.0279 0.0487
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0181 0.0315
Echinococcus multilocularis transportin 1 0.0006 0.0003 0.0003
Brugia malayi G protein-coupled receptor F59B2.13 0.005 0.0336 0.0592
Schistosoma mansoni DNA helicase recq5 0.001 0.0033 0.0033
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.1683 0.1683
Leishmania major mitochondrial DNA topoisomerase II 0.0042 0.0279 0.0487
Mycobacterium ulcerans beta-lactamase 0.0075 0.0528 1
Plasmodium vivax importin-beta 2, putative 0.0029 0.0181 0.34
Plasmodium falciparum endoplasmin, putative 0.0042 0.0279 1
Brugia malayi hypothetical protein 0.005 0.0336 0.0592
Schistosoma mansoni smad1 5 8 and 0.0008 0.002 0.002
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0042 0.0279 0.4739
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Schistosoma mansoni pyruvate dehydrogenase 0.0717 0.5353 0.5353
Echinococcus granulosus hypothetical protein 0.005 0.0336 0.0336
Loa Loa (eye worm) MH1 domain-containing protein 0.0008 0.002 0.0036
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0123 0.0123
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0195 0.1427 0.2516
Brugia malayi Calcitonin receptor-like protein seb-1 0.0247 0.1818 0.3206
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0094 0.0669 0.0669
Entamoeba histolytica Ran family GTPase 0.0022 0.0123 0.4222
Schistosoma mansoni neuropeptide receptor 0.005 0.0336 0.0336
Trypanosoma cruzi DNA topoisomerase II, putative 0.0042 0.0279 0.04
Brugia malayi Bloom's syndrome protein homolog 0.0023 0.0136 0.024
Brugia malayi heat shock protein 90 0.0042 0.0279 0.0492
Echinococcus granulosus smad 0.0008 0.002 0.002
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0528 0.0844
Echinococcus multilocularis rhodopsin orphan GPCR 0.005 0.0336 0.0336
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0312 0.2312 0.4078
Loa Loa (eye worm) hypothetical protein 0.0009 0.0027 0.0048
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.014 0.0649
Schistosoma mansoni rhodopsin-like orphan GPCR 0.005 0.0336 0.0336
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0035 0.0061
Brugia malayi RE15519p 0.005 0.0336 0.0592
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0181 0.0786
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Loa Loa (eye worm) hypothetical protein 0.0075 0.0528 0.0931
Loa Loa (eye worm) hypothetical protein 0.005 0.0336 0.0592
Trichomonas vaginalis receptor histidine kinase, putative 0.0042 0.0279 0.1307
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.0033 0.0059
Echinococcus multilocularis G protein coupled receptor 139 0.1334 1 1
Loa Loa (eye worm) beta-lactamase 0.0075 0.0528 0.0931
Echinococcus granulosus rhodopsin orphan GPCR 0.005 0.0336 0.0336
Mycobacterium ulcerans hypothetical protein 0.0075 0.0528 1
Echinococcus granulosus heat shock protein 90 0.0042 0.0279 0.0279
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0078 0.0549 0.0549
Echinococcus granulosus neuropeptide FF receptor 2 0.005 0.0336 0.0336
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0042 0.0279 0.0487
Brugia malayi beta-lactamase 0.0075 0.0528 0.0931
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0528 0.0927

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.5623 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) 0.9285 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 35.4813 uM PubChem BioAssay. qHTS for Inhibitors of Vif-A3G Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.