Detailed information for compound 1638485

Basic information

Technical information
  • TDR Targets ID: 1638485
  • Name: 4-naphthalen-2-yl-N-[4-(phenoxy)phenyl]-1,3-t hiazol-2-amine
  • MW: 394.488 | Formula: C25H18N2OS
  • H donors: 1 H acceptors: 1 LogP: 7.27 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)Oc1ccc(cc1)Nc1scc(n1)c1ccc2c(c1)cccc2
  • InChi: 1S/C25H18N2OS/c1-2-8-22(9-3-1)28-23-14-12-21(13-15-23)26-25-27-24(17-29-25)20-11-10-18-6-4-5-7-19(18)16-20/h1-17H,(H,26,27)
  • InChiKey: QLTWZLWLRMAAGH-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(2-naphthyl)-N-[4-(phenoxy)phenyl]thiazol-2-amine
  • 4-(2-naphthyl)-N-[4-(phenoxy)phenyl]-2-thiazolamine
  • [4-(2-naphthyl)thiazol-2-yl]-[4-(phenoxy)phenyl]amine
  • AG-205/11559331
  • A1672/0071294
  • ZINC02911356

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0214 0.0607 0.0604
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0152 0.042 0.042
Echinococcus multilocularis Glutaredoxin protein 5 0.002 0.0019 0.0017
Trypanosoma brucei target of rapamycin kinase 3, putative 0.264 0.7954 0.7942
Echinococcus granulosus Nuclear hormone receptor HR96 0.0072 0.0177 0.0175
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0214 0.0607 0.0605
Schistosoma mansoni fkbp-rapamycin associated protein 0.0627 0.1858 0.1855
Toxoplasma gondii FATC domain-containing protein 0.0627 0.1858 0.2451
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0152 0.042 0.0417
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0214 0.0607 0.0604
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0214 0.0607 0.0554
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0152 0.042 0.0417
Trichomonas vaginalis PIKK family atypical protein kinase 0.2637 0.7946 0.7945
Echinococcus granulosus voltage gated potassium channel 0.0022 0.0024 0.0023
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0037 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.1112 0.3326 0.3324
Loa Loa (eye worm) phosphatidylinositol 3 0.1112 0.3326 0.3326
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0214 0.0607 0.0588
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.1112 0.3326 0.3288
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0214 0.0607 0.0605
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.005 0.011 0.011
Echinococcus granulosus FTZ F1 alpha 0.0152 0.042 0.0419
Trichomonas vaginalis PIKK family atypical protein kinase 0.0214 0.0607 0.0604
Entamoeba histolytica protein kinase, putative 0.0032 0.0056 0.0037
Leishmania major peptidylprolyl isomerase-like protein 0.0058 0.0134 0.0098
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0214 0.0607 0.0604
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.1112 0.3326 0.3325
Schistosoma mansoni nuclear hormone receptor 0.0072 0.0177 0.0173
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0017 0.0053
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0214 0.0607 0.0588
Echinococcus multilocularis ecdysone induced protein 78C 0.0152 0.042 0.0419
Echinococcus multilocularis thyroid hormone receptor alpha 0.0152 0.042 0.0419
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.1112 0.3326 0.3324
Echinococcus granulosus lamin 0.0029 0.0047 0.0046
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.0169 0.0166
Schistosoma mansoni immunophilin 0.005 0.011 0.0106
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0072 0.0177 0.0173
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.3315 1 1
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0022 0.0024 0.0021
Schistosoma mansoni lamin 0.0029 0.0047 0.0044
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0152 0.042 0.0419
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0026 0.0006
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1112 0.3326 0.3313
Trichomonas vaginalis PIKK family atypical protein kinase 0.2152 0.6477 0.6476
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0214 0.0607 0.0588
Plasmodium vivax hypothetical protein, conserved 0.0214 0.0607 1
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0214 0.0607 0.0604
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0214 0.0607 0.0588
Onchocerca volvulus 0.0072 0.0177 0.2454
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0627 0.1858 0.1855
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0214 0.0607 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.179 0.5381 0.5379
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0214 0.0607 0.0554
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0627 0.1858 0.1842
Schistosoma mansoni retinoic acid receptor RXR 0.0152 0.042 0.0417
Schistosoma mansoni hypothetical protein 0.0044 0.0092 0.0089
Schistosoma mansoni thyroid hormone receptor 0.0152 0.042 0.0417
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0152 0.042 0.0417
Trichomonas vaginalis PIKK family atypical protein kinase 0.1787 0.5373 0.5371
Loa Loa (eye worm) hypothetical protein 0.008 0.0203 0.0203
Trichomonas vaginalis PIKK family atypical protein kinase 0.2637 0.7946 0.7945
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0214 0.0607 0.0604
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0026 0.0037 0.1676
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0214 0.0607 0.0604
Brugia malayi nuclear receptor RXR 0.008 0.0203 0.0199
Schistosoma mansoni hypothetical protein 0.0044 0.0092 0.0089
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0152 0.042 0.0417
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0214 0.0607 0.0604
Brugia malayi steroid hormone receptor 0.0152 0.042 0.0417
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0214 0.0607 0.0604
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0627 0.1858 0.1842
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0214 0.0607 0.0588
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0072 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0072 0.0177 0.0177
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0627 0.1858 0.1842
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0214 0.0607 1
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0015 0.0004 0.0004
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0047 0.0047
Entamoeba histolytica hypothetical protein 0.0039 0.0077 0.0057
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0015 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0072 0.0177 0.0177
Schistosoma mansoni hypothetical protein 0.0485 0.1427 0.1424
Brugia malayi nuclear receptor RXR 0.0072 0.0177 0.0173
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0058 0.0134 0.0078
Loa Loa (eye worm) AGC/AKT protein kinase 0.0032 0.0056 0.0056
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0214 0.0607 0.0604
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0058 0.0134 1
Echinococcus granulosus Niemann Pick C1 protein 0.0152 0.0419 0.0418
Echinococcus granulosus hyperpolarization activated cyclic 0.0015 0.0004 0.0002
Brugia malayi Nuclear hormone receptor-like 1 0.008 0.0203 0.0199
Leishmania major hypothetical protein, conserved 0.0214 0.0607 0.0572
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0152 0.042 0.042
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0037 0.0033
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0152 0.042 0.0417
Loa Loa (eye worm) phosphatidylinositol kinase 0.0214 0.0607 0.0607
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0074 0.0184 0.0181
Trichomonas vaginalis PIKK family atypical protein kinase 0.089 0.2653 0.265
Echinococcus multilocularis voltage gated potassium channel 0.0022 0.0024 0.0023
Echinococcus multilocularis FTZ F1 alpha 0.0152 0.042 0.0419
Leishmania major fk506-binding protein 1-like protein 0.0058 0.0134 0.0098
Trichomonas vaginalis fk506-binding protein, putative 0.0058 0.0134 0.0131
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0015 0.0004 0.0002
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0214 0.0607 0.0604
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0152 0.042 0.0419
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0214 0.0607 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2466 0.7427 0.7426
Trichomonas vaginalis PIKK family atypical protein kinase 0.2466 0.7427 0.7426
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0214 0.0607 0.0754
Echinococcus multilocularis lamin 0.0029 0.0047 0.0046
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0058 0.0134 0.0134
Echinococcus multilocularis musashi 0.0029 0.0047 0.0046
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0214 0.0607 0.0604
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0024 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0214 0.0607 0.0604
Schistosoma mansoni hypothetical protein 0.0039 0.0077 0.0073
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0152 0.042 0.0419
Trichomonas vaginalis PIKK family atypical protein kinase 0.2224 0.6694 0.6693
Trichomonas vaginalis PIKK family atypical protein kinase 0.2466 0.7427 0.7426
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0214 0.0607 1
Loa Loa (eye worm) hypothetical protein 0.0676 0.2005 0.2005
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0214 0.0607 0.0605
Echinococcus granulosus serine threonine protein kinase nrc 0.002 0.002 0.0018
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0214 0.0607 0.0754
Loa Loa (eye worm) hypothetical protein 0.0627 0.1858 0.1858
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0017
Echinococcus granulosus cyclic nucleotide gated cation channel 0.0015 0.0004 0.0002
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0152 0.042 0.0419
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0876 0.2613 0.2611
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.008 0.0203 0.0201
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.3315 1 1
Entamoeba histolytica protein kinase, putative 0.0032 0.0056 0.0037
Echinococcus granulosus survival motor neuron protein 1 0.0256 0.0733 0.0731
Mycobacterium leprae conserved hypothetical protein 0.0214 0.0607 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.179 0.5381 0.5379
Echinococcus multilocularis nervana 2 0.002 0.0019 0.0017
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0214 0.0607 0.0604
Echinococcus multilocularis expressed conserved protein 0.01 0.0262 0.026
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0058 0.0134 0.1984
Entamoeba histolytica hypothetical protein 0.0214 0.0607 0.0588
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0485 0.1427 0.1426
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0152 0.042 0.0419
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0214 0.0607 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0152 0.042 0.042
Entamoeba histolytica hypothetical protein 0.0039 0.0077 0.0057
Entamoeba histolytica hypothetical protein 0.0214 0.0607 0.0588
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0214 0.0607 0.0604
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.2466 0.7427 0.7426
Trichomonas vaginalis PIKK family atypical protein kinase 0.179 0.5381 0.5379
Loa Loa (eye worm) hypothetical protein 0.0072 0.0177 0.0177
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0214 0.0607 0.0605
Schistosoma mansoni voltage-gated potassium channel 0.0022 0.0024 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0152 0.042 0.0417
Entamoeba histolytica acyl-CoA synthetase, putative 0.0026 0.0037 0.0017
Schistosoma mansoni immunophilin 0.0058 0.0134 0.0131
Loa Loa (eye worm) hypothetical protein 0.0485 0.1427 0.1427
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0017
Brugia malayi tailless protein 0.0072 0.0177 0.0173
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0152 0.042 0.0417
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0627 0.1858 0.1857
Echinococcus granulosus ecdysone induced protein 78C 0.0152 0.042 0.0419
Trichomonas vaginalis PIKK family atypical protein kinase 0.1112 0.3326 0.3324
Schistosoma mansoni serine/threonine-protein kinase 0.0022 0.0026 0.0022
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0056 0.0053
Schistosoma mansoni patched 1 0.0046 0.0097 0.0094
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0058 0.0134 0.0114
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0214 0.0607 0.0607
Brugia malayi CHE-14 protein 0.0046 0.0097 0.0094
Brugia malayi nuclear hormone receptor family member odr-7 0.0072 0.0177 0.0173
Loa Loa (eye worm) nuclear receptor NHR-67 0.0072 0.0177 0.0177
Onchocerca volvulus 0.0052 0.0117 0.1407
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.1962 0.5902 0.59
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.0006 0.0006
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0069 0.0169 0.0166
Leishmania major phosphatidylinositol 3-related kinase, putative 0.1112 0.3326 0.3302
Echinococcus multilocularis Niemann Pick C1 protein 0.0106 0.0281 0.028
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0108 0.0286 0.0283
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0214 0.0607 1
Brugia malayi FAT domain containing protein 0.0485 0.1427 0.1424
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0077 0.0073
Brugia malayi hypothetical protein 0.008 0.0203 0.0199
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0058 0.0134 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0627 0.1858 0.1855
Schistosoma mansoni nuclear receptor 0.0072 0.0177 0.0173
Loa Loa (eye worm) hypothetical protein 0.0072 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0015 0.0004 0.0004
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0214 0.0607 0.0605
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0214 0.0607 1
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0058 0.0134 0.0131
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0214 0.0607 0.0588
Trichomonas vaginalis PIKK family atypical protein kinase 0.1112 0.3326 0.3324
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.3315 1 1
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.005 0.011 0.0108
Leishmania major phosphatidylinositol 4-kinase, putative 0.0214 0.0607 0.0572
Trichomonas vaginalis PIKK family atypical protein kinase 0.0627 0.1858 0.1855
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0214 0.0607 0.0554
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0056 0.0053
Leishmania major phosphatidylinositol 3-kinase, putative 0.1112 0.3326 0.3302
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0214 0.0607 0.0754
Schistosoma mansoni steroid hormone receptor ad4bp 0.0152 0.042 0.0417
Loa Loa (eye worm) hypothetical protein 0.0413 0.121 0.121
Loa Loa (eye worm) hypothetical protein 0.0029 0.0047 0.0047
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0214 0.0607 0.0604
Loa Loa (eye worm) hypothetical protein 0.0214 0.0607 0.0607
Echinococcus multilocularis sterol regulatory element binding protein 0.0046 0.0097 0.0096
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0058 0.0134 0.0131
Echinococcus multilocularis cyclic nucleotide gated cation channel 0.0015 0.0004 0.0002
Onchocerca volvulus 0.0072 0.0177 0.2454
Schistosoma mansoni intermediate filament proteins 0.0029 0.0047 0.0044
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0152 0.042 0.0417
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0214 0.0607 0.0588
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0106 0.0281 0.0262
Brugia malayi nuclear receptor NHR-88 0.0152 0.042 0.0417
Loa Loa (eye worm) hypothetical protein 0.0072 0.0177 0.0177
Echinococcus multilocularis protein dispatched 1 0.0052 0.0117 0.0115
Echinococcus granulosus sterol regulatory element binding protein 0.0046 0.0097 0.0096
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0214 0.0607 0.0588
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0072 0.0177 0.0175
Brugia malayi ecdysteroid receptor 0.0152 0.042 0.0417
Onchocerca volvulus 0.0029 0.0047 0.0187
Schistosoma mansoni voltage-gated potassium channel 0.0081 0.0205 0.0201
Loa Loa (eye worm) hypothetical protein 0.008 0.0203 0.0203
Giardia lamblia Hypothetical protein 0.0214 0.0607 0.0588
Trypanosoma cruzi Protein kinase B 0.0022 0.0026 0.0006
Trichomonas vaginalis PIKK family atypical protein kinase 0.1112 0.3326 0.3324
Plasmodium vivax hypothetical protein 0.0214 0.0607 1
Loa Loa (eye worm) hypothetical protein 0.0152 0.042 0.042
Loa Loa (eye worm) hypothetical protein 0.0214 0.0607 0.0607
Trichomonas vaginalis PIKK family atypical protein kinase 0.3315 1 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0152 0.042 0.0417
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0058 0.0134 0.0114
Echinococcus granulosus Protein patched homolog 1 0.0046 0.0097 0.0096
Schistosoma mansoni zinc finger protein 0.0072 0.0177 0.0173
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0214 0.0607 0.0605
Echinococcus granulosus lamin dm0 0.0029 0.0047 0.0046
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.264 0.7954 0.7946
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0152 0.042 0.0417
Brugia malayi orphan nuclear receptor NR2E1 0.0072 0.0177 0.0173
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0214 0.0607 0.0605
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0022 0.0026 0.0006
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0627 0.1858 0.1855
Brugia malayi hypothetical protein 0.008 0.0203 0.0199
Echinococcus granulosus Glutaredoxin protein 5 0.002 0.0019 0.0017
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0214 0.0607 0.0588
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0214 0.0607 0.0588
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.3315 1 1
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0074 0.0184 0.0184
Echinococcus granulosus nuclear receptor nhr 48 0.0072 0.0177 0.0175
Onchocerca volvulus 0.0214 0.0607 1
Loa Loa (eye worm) FKBP5 protein 0.0058 0.0134 0.0134
Schistosoma mansoni hypothetical protein 0.0044 0.0092 0.0089
Echinococcus multilocularis serine protein kinase ATM 0.0627 0.1858 0.1857
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.005 0.011 0.0108
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0072 0.0177 0.0175
Trypanosoma cruzi target of rapamycin kinase 3 0.264 0.7954 0.795
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0152 0.042 0.042
Schistosoma mansoni serine/threonine-protein kinase 0.0022 0.0026 0.0022
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0072 0.0177 0.2454
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.3315 1 1
Schistosoma mansoni nuclear hormone receptor 0.0152 0.042 0.0417
Schistosoma mansoni nuclear hormone receptor 0.0072 0.0177 0.0173
Loa Loa (eye worm) phosphatidylinositol 3 0.0214 0.0607 0.0607
Entamoeba histolytica hypothetical protein 0.0214 0.0607 0.0588
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0214 0.0607 0.0604
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0214 0.0607 0.0754
Brugia malayi Nuclear hormone receptor-like 1 0.008 0.0203 0.0199
Brugia malayi hypothetical protein 0.0039 0.0077 0.0073
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.002 0.002 0.0047
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0214 0.0607 0.0588
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0072 0.0177 0.0175
Schistosoma mansoni coup transcription factor 0.0152 0.042 0.0417
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0214 0.0607 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.2637 0.7946 0.7945
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0214 0.0607 0.0604
Giardia lamblia Phosphatidylinositol 4-kinase 0.0214 0.0607 0.0588
Entamoeba histolytica hypothetical protein 0.0214 0.0607 0.0588
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0152 0.042 0.0417
Echinococcus multilocularis hyperpolarization activated cyclic 0.0015 0.0004 0.0002
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0058 0.0134 0.1984
Onchocerca volvulus 0.0152 0.042 0.6726
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0152 0.042 0.0419
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.008 0.0203 0.0199
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.3315 1 1
Mycobacterium tuberculosis Conserved hypothetical protein 0.0214 0.0607 1
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0152 0.042 0.0417
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0017
Entamoeba histolytica hypothetical protein 0.0039 0.0077 0.0057
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0072 0.0177 0.0173
Schistosoma mansoni retinoid-x-receptor (RXR) 0.008 0.0203 0.0199
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0214 0.0607 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.3315 1 1
Echinococcus multilocularis cyclic nucleotide gated cation channel alpha 3 0.0015 0.0004 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.0046 0.0097 0.0094
Brugia malayi hypothetical protein 0.0072 0.0177 0.0173
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0037
Trichomonas vaginalis PIKK family atypical protein kinase 0.1981 0.5959 0.5957
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.3315 1 1
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0056 0.0053
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0214 0.0607 0.0604
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0026 0.0037 0.0384
Loa Loa (eye worm) hypothetical protein 0.0152 0.042 0.042
Schistosoma mansoni survival motor neuron protein 0.0052 0.0117 0.0113
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0058 0.0134 0.0114
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0214 0.0607 0.0604
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0214 0.0607 0.0605
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0058 0.0134 0.0114
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0072 0.0177 0.0175
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0037 0.0033
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0056 0.0053
Loa Loa (eye worm) hypothetical protein 0.008 0.0203 0.0203
Brugia malayi nuclear hormone receptor 0.0152 0.042 0.0417
Loa Loa (eye worm) hypothetical protein 0.0014 0.0002 0.0002
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0214 0.0607 0.0604
Leishmania major hypothetical protein, unknown function 0.0214 0.0607 0.0572
Loa Loa (eye worm) phosphatidylinositol 3 0.3315 1 1
Schistosoma mansoni hypothetical protein 0.0044 0.0092 0.0089
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0214 0.0607 0.0604
Echinococcus granulosus hyperpolarization activated cyclic 0.0015 0.0004 0.0002
Loa Loa (eye worm) phosphatidylinositol 3 0.0214 0.0607 0.0607
Brugia malayi Steroid receptor seven-up type 2 0.0152 0.042 0.0417
Trichomonas vaginalis PIKK family atypical protein kinase 0.1112 0.3326 0.3324
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.0006 0.0003
Brugia malayi nuclear receptor NHR-88 0.0072 0.0177 0.0173
Echinococcus multilocularis lamin dm0 0.0029 0.0047 0.0046
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0026 0.0037 0.1676
Loa Loa (eye worm) phosphatidylinositol 3 0.0214 0.0607 0.0607
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0152 0.042 0.0417
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0022 0.0024 0.0023
Loa Loa (eye worm) hypothetical protein 0.0056 0.0128 0.0128
Trichomonas vaginalis PIKK family atypical protein kinase 0.2637 0.7946 0.7945
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0214 0.0607 0.0588
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.1112 0.3326 0.3324
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0627 0.1858 0.1857
Loa Loa (eye worm) hypothetical protein 0.0072 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.008 0.0203 0.0203
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0214 0.0607 0.0604
Trichomonas vaginalis PIKK family atypical protein kinase 0.179 0.5381 0.5379
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0152 0.042 0.0417
Trichomonas vaginalis PIKK family atypical protein kinase 0.1787 0.5373 0.5371
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0058 0.0134 0.0132
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0056 0.0053
Loa Loa (eye worm) hypothetical protein 0.0046 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.0256 0.0733 0.0733
Trichomonas vaginalis PIKK family atypical protein kinase 0.2466 0.7427 0.7426
Onchocerca volvulus Protein ultraspiracle homolog 0.0152 0.042 0.6726
Brugia malayi p70 ribosomal S6 kinase beta 0.003 0.005 0.0047
Loa Loa (eye worm) hypothetical protein 0.0072 0.0177 0.0177
Echinococcus granulosus Niemann Pick C1 protein 0.0106 0.0281 0.028
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0152 0.042 0.0417
Schistosoma mansoni RAR-like nuclear receptor 0.0152 0.042 0.0417
Entamoeba histolytica acyl-coA synthetase, putative 0.0026 0.0037 0.0017
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0052 0.0117 0.0113
Trichomonas vaginalis conserved hypothetical protein 0.0699 0.2075 0.2072
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0152 0.042 0.0417
Brugia malayi conserved hypotetical protein 0.0072 0.0177 0.0173
Loa Loa (eye worm) hypothetical protein 0.0026 0.0037 0.0037
Echinococcus multilocularis 0.0214 0.0607 0.0605
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0152 0.042 0.0419
Loa Loa (eye worm) phosphatidylinositol 3 0.0214 0.0607 0.0607
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0077 0.0075
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0214 0.0607 0.0605
Brugia malayi nuclear hormone receptor 0.0072 0.0177 0.0173
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.3315 1 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.2466 0.7427 1
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.002 0.002 0.0047
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0037 0.1676
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0214 0.0607 0.0588
Brugia malayi Niemann-Pick C1 protein precursor 0.0106 0.0281 0.0278
Echinococcus granulosus nervana 2 0.002 0.0019 0.0017
Loa Loa (eye worm) hypothetical protein 0.0072 0.0177 0.0177
Echinococcus multilocularis rac serine:threonine kinase 0.0022 0.0026 0.0024
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0026 0.0037 0.1676
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0056 0.0053
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0214 0.0607 0.0554
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0058 0.0134 0.0131
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0072 0.0177 0.0175
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0058 0.0134 0.0132
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0485 0.1427 0.1426
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0214 0.0607 1
Leishmania major phosphatidylinositol kinase, putative 0.0214 0.0607 0.0572
Entamoeba histolytica protein kinase, putative 0.003 0.005 0.0031
Brugia malayi ecdysone receptor 0.0072 0.0177 0.0173
Echinococcus granulosus thyroid hormone receptor alpha 0.0072 0.0177 0.0175
Loa Loa (eye worm) hypothetical protein 0.0152 0.042 0.042
Loa Loa (eye worm) hypothetical protein 0.0019 0.0017 0.0017
Echinococcus multilocularis nuclear receptor nhr 48 0.0072 0.0177 0.0175
Onchocerca volvulus Bile acid receptor homolog 0.0152 0.042 0.6726
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0214 0.0607 0.0604
Leishmania major phosphatidylinositol kinase related protein, putative 0.0214 0.0607 0.0572
Trichomonas vaginalis PIKK family atypical protein kinase 0.1961 0.5899 0.5898
Brugia malayi Nuclear hormone receptor-like 1 0.0152 0.042 0.0417
Echinococcus multilocularis hyperpolarization activated cyclic 0.0015 0.0004 0.0002
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.002 0.002 0.0018
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0214 0.0607 0.0605
Brugia malayi hypothetical protein 0.0072 0.0177 0.0173
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0072 0.0177 0.2454
Trichomonas vaginalis conserved hypothetical protein 0.0485 0.1427 0.1424
Trichomonas vaginalis PIKK family atypical protein kinase 0.1981 0.5959 0.5957
Schistosoma mansoni immunophilin 0.0058 0.0134 0.0131
Schistosoma mansoni thyroid hormone receptor 0.0152 0.042 0.0417
Echinococcus multilocularis protein patched 0.0046 0.0097 0.0096
Brugia malayi intermediate filament protein 0.0029 0.0047 0.0044
Echinococcus multilocularis Zinc finger, PHD finger 0.0214 0.0607 0.0605
Trichomonas vaginalis PIKK family atypical protein kinase 0.3315 1 1
Schistosoma mansoni hypothetical protein 0.0214 0.0607 0.0604
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.008 0.0203 0.0201
Brugia malayi photoreceptor-specific nuclear receptor 0.0152 0.042 0.0417
Loa Loa (eye worm) hypothetical protein 0.0072 0.0177 0.0177
Echinococcus multilocularis survival motor neuron protein 1 0.0256 0.0733 0.0731
Echinococcus granulosus serine protein kinase ATM 0.0627 0.1858 0.1857
Trichomonas vaginalis PIKK family atypical protein kinase 0.0627 0.1858 0.1855
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.1112 0.3326 0.3288
Entamoeba histolytica hypothetical protein 0.0627 0.1858 0.1842
Giardia lamblia GTOR 0.3315 1 1
Brugia malayi Nuclear hormone receptor E75 0.0072 0.0177 0.0173
Schistosoma mansoni voltage-gated potassium channel 0.0081 0.0205 0.0201
Trichomonas vaginalis immunophilin, putative 0.0058 0.0134 0.0131
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0214 0.0607 0.0605
Loa Loa (eye worm) steroid hormone receptor 0.0152 0.042 0.042
Brugia malayi AMP-binding enzyme family protein 0.0026 0.0037 0.0033
Loa Loa (eye worm) hypothetical protein 0.0699 0.2075 0.2075
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0058 0.0134 0.0132
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0074 0.0184 0.0182
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.002 0.0019 0.0017
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0214 0.0607 0.0754
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0214 0.0607 0.0604
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0214 0.0607 0.0572
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0152 0.042 0.042
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0152 0.042 0.0417
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0026 0.0037 0.0384
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0152 0.042 0.0419
Echinococcus granulosus cyclic nucleotide gated cation channel alpha 3 0.0015 0.0004 0.0002
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.1112 0.3326 0.3313
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0152 0.042 0.6726
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0058 0.0134 0.0131
Loa Loa (eye worm) hypothetical protein 0.0152 0.042 0.042
Entamoeba histolytica protein kinase rad3, putative 0.0627 0.1858 0.1842
Loa Loa (eye worm) hypothetical protein 0.0152 0.042 0.042
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0058 0.0134 0.0114
Loa Loa (eye worm) hypothetical protein 0.0072 0.0177 0.0177
Echinococcus granulosus expressed conserved protein 0.01 0.0262 0.026
Brugia malayi nuclear hormone receptor family member nhr-6 0.0072 0.0177 0.0173
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0152 0.042 0.0417
Loa Loa (eye worm) hypothetical protein 0.0152 0.042 0.042
Onchocerca volvulus 0.0029 0.0047 0.0187
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0214 0.0607 0.0604
Brugia malayi hypothetical protein 0.0256 0.0733 0.073
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0699 0.2075 0.2745
Echinococcus granulosus serine/threonine protein kinase 0.0022 0.0026 0.0024
Loa Loa (eye worm) hypothetical protein 0.0152 0.042 0.042
Trichomonas vaginalis PIKK family atypical protein kinase 0.2466 0.7427 0.7426
Trichomonas vaginalis PIKK family atypical protein kinase 0.1961 0.5899 0.5898
Trichomonas vaginalis PIKK family atypical protein kinase 0.0413 0.121 0.1207
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0627 0.1858 0.1855
Onchocerca volvulus 0.0214 0.0607 1
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0214 0.0607 0.0588
Echinococcus granulosus Nuclear hormone receptor HR96 0.0072 0.0177 0.0175
Trichomonas vaginalis PIKK family atypical protein kinase 0.2637 0.7946 0.7945
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0214 0.0607 0.0605
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0152 0.042 0.042
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0072 0.0177 0.0175
Trichomonas vaginalis PIKK family atypical protein kinase 0.2831 0.8532 0.8531
Entamoeba histolytica PH domain containing protein kinase, putative 0.0022 0.0026 0.0006
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0017 0.5
Echinococcus multilocularis fk506 binding protein 0.0058 0.0134 0.0132
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0214 0.0607 0.0588
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0037 0.1676
Loa Loa (eye worm) hypothetical protein 0.0072 0.0177 0.0177
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0214 0.0607 0.0588
Loa Loa (eye worm) phosphatidylinositol 3 0.0214 0.0607 0.0607
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0214 0.0607 0.0605
Echinococcus multilocularis nervana 2 0.002 0.0019 0.0017
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0058 0.0134 0.0114
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0024
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.008 0.0203 0.0203
Brugia malayi Nuclear hormone receptor E75 0.0072 0.0177 0.0173
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0072 0.0177 0.0175
Echinococcus multilocularis potassium:sodium hyperpolarization activated 0.0015 0.0004 0.0002
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0058 0.0134 0.5
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0214 0.0607 0.0588
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0152 0.042 0.042
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0047 0.0044
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.3315 1 1
Schistosoma mansoni nuclear receptor 0.0072 0.0177 0.0173
Leishmania major phosphatidylinositol 3-kinase, putative 0.0214 0.0607 0.0572
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0152 0.042 0.0419
Loa Loa (eye worm) hypothetical protein 0.0106 0.0281 0.0281
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0058 0.0134 0.0114
Entamoeba histolytica hypothetical protein 0.0039 0.0077 0.0057
Mycobacterium ulcerans hypothetical protein 0.0026 0.0037 0.1676
Loa Loa (eye worm) hypothetical protein 0.0072 0.0177 0.0177
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0152 0.042 0.0419
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0214 0.0607 0.0588
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.3315 1 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.1112 0.3326 0.3325
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0413 0.121 0.1193
Schistosoma mansoni hypothetical protein 0.0052 0.0117 0.0113
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0026 0.0037 0.1676
Loa Loa (eye worm) hypothetical protein 0.0064 0.0154 0.0154
Loa Loa (eye worm) nuclear hormone receptor 0.0072 0.0177 0.0177
Loa Loa (eye worm) hypothetical protein 0.0152 0.042 0.042
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1568 0.4708 0.4678
Schistosoma mansoni lamin 0.0029 0.0047 0.0044
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0077 0.0075
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0214 0.0607 0.0604
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0047 0.0047
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0627 0.1858 0.1812
Echinococcus granulosus nervana 2 0.002 0.0019 0.0017
Loa Loa (eye worm) DR-78 0.0072 0.0177 0.0177
Trichomonas vaginalis conserved hypothetical protein 0.0413 0.121 0.1207
Mycobacterium ulcerans acyl-CoA synthetase 0.0026 0.0037 0.1676
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0058 0.0134 0.0078
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0152 0.042 0.0417
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0074 0.0184 0.0182
Loa Loa (eye worm) hypothetical protein 0.0072 0.0177 0.0177
Trichomonas vaginalis PIKK family atypical protein kinase 0.1787 0.5373 0.5371
Trichomonas vaginalis PIKK family atypical protein kinase 0.1981 0.5959 0.5957
Echinococcus granulosus potassium:sodium hyperpolarization activated 0.0015 0.0004 0.0002
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0214 0.0607 0.0588
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1377 0.413 0.4096
Echinococcus granulosus intermediate filament protein 0.0029 0.0047 0.0046
Trichomonas vaginalis PIKK family atypical protein kinase 0.2466 0.7427 0.7426
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0046 0.0097 0.0097
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.002 0.0019 0.0017
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0152 0.042 0.0419
Echinococcus multilocularis Niemann Pick C1 protein 0.0152 0.0419 0.0418
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0214 0.0607 0.0588
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0058 0.0134 0.0131
Trichomonas vaginalis AGC family protein kinase 0.0032 0.0056 0.0053
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.002 0.002 0.0018
Loa Loa (eye worm) hypothetical protein 0.008 0.0203 0.0203
Brugia malayi nuclear receptor NHR-67 0.0072 0.0177 0.0173
Schistosoma mansoni nuclear receptor nhr-48 0.0072 0.0177 0.0173
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0152 0.042 0.0419
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.3315 1 1
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0022 0.0024 0.0023
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0046
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.003 0.005 0.005
Brugia malayi Protein kinase domain containing protein 0.0032 0.0056 0.0053
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0152 0.042 0.0419

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) Inhibition of COX2 by fluorescence assay ChEMBL. 22516282
Inhibition (binding) Inhibition of COX2 at 5 uM by fluorescence assay ChEMBL. 22516282

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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