Detailed information for compound 1646327

Basic information

Technical information
  • TDR Targets ID: 1646327
  • Name: N-(phenylmethyl)-2H-triazolo[4,5-e]pyrimidin- 7-amine
  • MW: 226.237 | Formula: C11H10N6
  • H donors: 2 H acceptors: 4 LogP: 1.52 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: c1ccc(cc1)CNc1ncnc2c1[nH]nn2
  • InChi: 1S/C11H10N6/c1-2-4-8(5-3-1)6-12-10-9-11(14-7-13-10)16-17-15-9/h1-5,7H,6H2,(H2,12,13,14,15,16,17)
  • InChiKey: WUNPRFMUHCNVCF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • benzyl-(2H-triazolo[4,5-e]pyrimidin-7-yl)amine
  • N-(phenylmethyl)-2H-[1,2,3]triazolo[4,5-e]pyrimidin-7-amine
  • 16347-47-0
  • NSC401055
  • NCI60_003757

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0062 0.0053
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0119 0.0167
Onchocerca volvulus Putative sulfate transporter 0.0215 0.0844 0.0835
Loa Loa (eye worm) hypothetical protein 0.1179 0.4981 0.498
Schistosoma mansoni lipoxygenase 0.0124 0.0454 0.0444
Onchocerca volvulus 0.0043 0.0106 0.0097
Echinococcus multilocularis fat cadherin tumor suppressor 0.046 0.1893 0.1885
Echinococcus granulosus protein jagged 2 0.046 0.1893 0.1885
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0556 0.2307 0.2307
Schistosoma mansoni hypothetical protein 0.0033 0.0062 0.0053
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0029 0.0046 0.0037
Mycobacterium ulcerans transferase 0.0071 0.0226 0.0299
Toxoplasma gondii hypothetical protein 0.0556 0.2307 1
Loa Loa (eye worm) hypothetical protein 0.2349 1 1
Echinococcus granulosus sodium and chloride dependent glycine 0.0043 0.0106 0.0097
Onchocerca volvulus Peroxidase homolog 0.2349 1 1
Schistosoma mansoni lipoxygenase 0.0087 0.0293 0.0284
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0029 0.0046 0.0037
Toxoplasma gondii EGF family domain-containing protein 0.046 0.1893 0.8152
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0029 0.0046 0.0046
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0119 0.0109
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0029 0.0046 0.0037
Schistosoma mansoni hypothetical protein 0.0071 0.0227 0.0217
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0029 0.0046 0.0037
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0043 0.0106 0.0097
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0079 0.0083
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0029 0.0046 0.0037
Echinococcus granulosus carbonic anhydrase 0.0556 0.2307 0.23
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0078 0.0081
Echinococcus granulosus GPCR family 2 0.0033 0.0062 0.0053
Onchocerca volvulus 0.0029 0.0046 0.0037
Echinococcus granulosus sodium and chloride dependent glycine 0.0043 0.0106 0.0097
Giardia lamblia High cysteine protein 0.046 0.1893 1
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0043 0.0106 0.0097
Brugia malayi Calcium binding EGF domain containing protein 0.046 0.1893 0.1893
Brugia malayi cytochrome c oxidase subunit II 0.0019 0.0002 0.0002
Echinococcus multilocularis fibropellin Ia 0.046 0.1893 0.1885
Loa Loa (eye worm) notch protein 0.046 0.1893 0.1892
Loa Loa (eye worm) hypothetical protein 0.046 0.1893 0.1892
Brugia malayi Protein kinase domain containing protein 0.0304 0.1223 0.1223
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0047 0.0124 0.0115
Mycobacterium tuberculosis Probable transmembrane cytochrome C oxidase (subunit II) CtaC 0.0047 0.0124 0.005
Onchocerca volvulus 0.2349 1 1
Echinococcus granulosus slit 2 protein 0.046 0.1893 0.1885
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0106 0.2534
Schistosoma mansoni hypothetical protein 0.0133 0.049 0.048
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0034 0.0068 0.0046
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0029 0.0046 0.0037
Brugia malayi EGF-like domain containing protein 0.046 0.1893 0.1893
Echinococcus granulosus geminin 0.0179 0.0687 0.0678
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0124 0.0454 0.0444
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0119 0.0145
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0008
Brugia malayi photoreceptor-specific nuclear receptor 0.0029 0.0046 0.0046
Entamoeba histolytica acetyltransferase, putative 0.0074 0.0239 0.0254
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0039 0.0018
Leishmania major carbonic anhydrase family protein, putative 0.1285 0.5436 1
Schistosoma mansoni notch 0.046 0.1893 0.1885
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0038 0.0017
Wolbachia endosymbiont of Brugia malayi N-acetylglucosamine-1-phosphate uridyltransferase 0.0074 0.0239 0.2761
Entamoeba histolytica ankyrin, putative 0.0074 0.0239 0.0255
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0029 0.0046 0.0037
Loa Loa (eye worm) hypothetical protein 0.2349 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0029 0.0046 0.0044
Echinococcus multilocularis slit 2 protein 0.046 0.1893 0.1885
Schistosoma mansoni retinoic acid receptor RXR 0.0029 0.0046 0.0037
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0043 0.0106 0.0097
Onchocerca volvulus Protein ultraspiracle homolog 0.0029 0.0046 0.0037
Brugia malayi Muscle positioning protein 4 0.046 0.1893 0.1893
Echinococcus multilocularis microsomal glutathione S transferase 3 0.0228 0.0897 0.0888
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0029 0.0046 0.0037
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0042 0.0103 0.0103
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0255 0.1014 0.1014
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0119 0.0109
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0029 0.0046 0.0037
Plasmodium falciparum amino acid transporter, putative 0.0043 0.0106 0.042
Onchocerca volvulus 0.046 0.1893 0.1885
Echinococcus multilocularis protein jagged 1 0.046 0.1893 0.1885
Echinococcus multilocularis neural cadherin 0.046 0.1893 0.1885
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0043 0.0106 0.0172
Onchocerca volvulus Slit protein homolog 0.046 0.1893 0.1885
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0304 0.1223 0.1221
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0068 0.0064
Echinococcus multilocularis protein jagged 1 0.046 0.1893 0.1885
Mycobacterium ulcerans hypothetical protein 0.0042 0.0103 0.0102
Loa Loa (eye worm) hypothetical protein 0.0042 0.0103 0.0101
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0029 0.0046 0.0037
Loa Loa (eye worm) hypothetical protein 0.046 0.1893 0.1892
Loa Loa (eye worm) hypothetical protein 0.0556 0.2307 0.2306
Schistosoma mansoni thyroid hormone receptor 0.0162 0.0615 0.0606
Mycobacterium ulcerans integral membrane transporter 0.0034 0.0068 0.0046
Loa Loa (eye worm) animal heme peroxidase 0.2349 1 1
Echinococcus multilocularis FTZ F1 alpha 0.0029 0.0046 0.0037
Entamoeba histolytica carbonic anhydrase, putative 0.1285 0.5436 1
Brugia malayi Cytochrome P450 family protein 0.0028 0.0039 0.0039
Echinococcus multilocularis protein jagged 2 0.046 0.1893 0.1885
Schistosoma mansoni hypothetical protein 0.046 0.1893 0.1885
Loa Loa (eye worm) hypothetical protein 0.0042 0.0103 0.0101
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0029 0.0046 0.0046
Mycobacterium tuberculosis Probable serine acetyltransferase CysE (sat) 0.0074 0.0239 0.0322
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0043 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.2349 1 1
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0042 0.0103 0.0093
Loa Loa (eye worm) calcium channel 0.0042 0.0103 0.0101
Schistosoma mansoni notch 0.046 0.1893 0.1885
Brugia malayi Blistered cuticle protein 3 0.2349 1 1
Echinococcus granulosus protein jagged 1 0.046 0.1893 0.1885
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0136 0.0502 0.0962
Trypanosoma brucei carbonic anhydrase-like protein 0.1151 0.486 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0054 0.0041
Echinococcus granulosus ecdysone induced protein 78C 0.0029 0.0046 0.0037
Schistosoma mansoni carbonic anhydrase-related 0.0556 0.2307 0.23
Brugia malayi Calcium binding EGF domain containing protein 0.046 0.1893 0.1893
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0046 0.0037
Schistosoma mansoni thyroid hormone receptor 0.0162 0.0615 0.0606
Echinococcus multilocularis mitogen activated protein kinase 14 0.0136 0.0502 0.0493
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0172 0.066 0.132
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0556 0.2307 0.2307
Trichomonas vaginalis conserved hypothetical protein 0.1492 0.6324 1
Schistosoma mansoni hypothetical protein 0.0033 0.0062 0.0053
Onchocerca volvulus Peroxidasin homolog 0.2349 1 1
Loa Loa (eye worm) hypothetical protein 0.0104 0.0369 0.0367
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0227 0.0227
Loa Loa (eye worm) hypothetical protein 0.2349 1 1
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0043 0.0106 0.0104
Loa Loa (eye worm) hypothetical protein 0.0043 0.0106 0.0104
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0038 0.0017
Loa Loa (eye worm) cytochrome oxidase subunit 2 0.0028 0.0043 0.0041
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0029 0.0046 0.0044
Plasmodium vivax cytochrome c oxidase subunit 2, putative 0.0047 0.0124 0.3006
Echinococcus granulosus protein jagged 1 0.046 0.1893 0.1885
Mycobacterium leprae PROBABLE TRANSFERASE 0.0071 0.0226 0.0341
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0103 0.0133
Loa Loa (eye worm) hypothetical protein 0.0043 0.0106 0.0104
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1151 0.486 0.4855
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0068 0.0064
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.1151 0.486 0.486
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0043 0.0106 0.0097
Brugia malayi EGF-like domain containing protein 0.046 0.1893 0.1893
Brugia malayi Cadherin domain containing protein 0.046 0.1893 0.1893
Echinococcus granulosus neurogenic locus notch protein 0.046 0.1893 0.1885
Schistosoma mansoni notch 0.046 0.1893 0.1885
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0068 0.0064
Schistosoma mansoni sodium-dependent amino acid transporter 0.0043 0.0106 0.0097
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0029 0.0046 0.0037
Schistosoma mansoni notch 0.046 0.1894 0.1886
Echinococcus granulosus carbonic anhydrase 0.0556 0.2307 0.23
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0119 0.0145
Loa Loa (eye worm) hypothetical protein 0.046 0.1893 0.1892
Loa Loa (eye worm) serotonin transporter b 0.0255 0.1014 0.1012
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0046 0.0046
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0369 0.0367
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0119 0.0117
Onchocerca volvulus 0.0047 0.0124 0.0115
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0049 0.0035
Schistosoma mansoni cytochrome c oxidase subunit II 0.0128 0.0472 0.0462
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0124 0.0454 0.0444
Toxoplasma gondii hypothetical protein 0.0043 0.0106 0.0172
Schistosoma mansoni Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] 0.046 0.1893 0.1885
Plasmodium vivax sulfate transporter, putative 0.0034 0.0068 0.1523
Loa Loa (eye worm) hypothetical protein 0.046 0.1893 0.1892
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0029 0.0046 0.0046
Echinococcus multilocularis notch 0.046 0.1893 0.1885
Brugia malayi Steroid receptor seven-up type 2 0.0029 0.0046 0.0046
Onchocerca volvulus Peroxidasin homolog 0.2349 1 1
Echinococcus multilocularis neurogenic locus protein delta 0.046 0.1893 0.1885
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0556 0.2307 0.2307
Brugia malayi Doublecortin family protein 0.0021 0.001 0.001
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0043 0.0106 0.0097
Loa Loa (eye worm) carbonic anhydrase 3 0.1151 0.486 0.4859
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0136 0.0502 0.0962
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0119 0.0239
Brugia malayi Cadherin domain containing protein 0.046 0.1893 0.1893
Loa Loa (eye worm) hypothetical protein 0.046 0.1893 0.1892
Brugia malayi phosphoinositide-dependent protein kinase I 0.0304 0.1223 0.1223
Onchocerca volvulus Bile acid receptor homolog 0.0029 0.0046 0.0037
Echinococcus granulosus serotonin transporter 0.0255 0.1014 0.1005
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.1151 0.486 0.4855
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0062 0.0053
Loa Loa (eye worm) hypothetical protein 0.046 0.1893 0.1892
Echinococcus multilocularis neurogenic locus notch protein 0.046 0.1893 0.1885
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0034 0.0068 0.006
Brugia malayi Transmembrane cell adhesion receptor mua-3 precursor, putative 0.046 0.1893 0.1893
Mycobacterium ulcerans transmembrane cytochrome C oxidase (subunit II) CtaC 0.0047 0.0124 0.0136
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0029 0.0046 0.0044
Trichomonas vaginalis conserved hypothetical protein 0.1492 0.6324 1
Entamoeba histolytica protein kinase, putative 0.0304 0.1223 0.2101
Trichomonas vaginalis maltose O-acetyltransferase, putative 0.0071 0.0226 0.0316
Echinococcus multilocularis mitogen activated protein kinase 11 0.0136 0.0502 0.0493
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0029 0.0046 0.0037
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0556 0.2307 0.2306
Loa Loa (eye worm) hypothetical protein 0.0037 0.0081 0.0079
Trichomonas vaginalis AGC family protein kinase 0.0304 0.1223 0.1899
Onchocerca volvulus 0.0215 0.0844 0.0835
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0029 0.0046 0.0044
Echinococcus granulosus protein jagged 2 0.046 0.1893 0.1885
Trichomonas vaginalis AGC family protein kinase 0.0304 0.1223 0.1899
Loa Loa (eye worm) cytochrome P450 family protein 0.0077 0.0249 0.0247
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0047 0.0124 0.0115
Loa Loa (eye worm) hypothetical protein 0.046 0.1893 0.1892
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0043 0.0106 0.0097
Loa Loa (eye worm) hypothetical protein 0.0037 0.0081 0.0079
Brugia malayi EGF-like domain containing protein 0.046 0.1893 0.1893
Loa Loa (eye worm) animal heme peroxidase 0.2349 1 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0119 0.0119
Schistosoma mansoni hypothetical protein 0.0033 0.0062 0.0053
Loa Loa (eye worm) solute carrier family 6 member 4 0.0255 0.1014 0.1012
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.0042 0.0103 0.0133
Loa Loa (eye worm) hypothetical protein 0.046 0.1893 0.1892
Loa Loa (eye worm) hypothetical protein 0.046 0.1893 0.1892
Schistosoma mansoni peroxidasin 0.2349 1 1
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0716 0.2993 0.6855
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0042 0.0103 0.0093
Loa Loa (eye worm) doublecortin family protein 0.0021 0.001 0.0008
Leishmania major carbonic anhydrase-like protein 0.1151 0.486 0.8933
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.009 0.0099
Loa Loa (eye worm) hypothetical protein 0.046 0.1893 0.1892
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0369 0.0369
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0034 0.0068 0.006
Brugia malayi notch-like transmembrane receptor 0.046 0.1893 0.1893
Schistosoma mansoni hypothetical protein 0.0033 0.0062 0.0053
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0042 0.0103 0.0093
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.1025 0.4318 1
Schistosoma mansoni hypothetical protein 0.0179 0.0687 0.0678
Mycobacterium leprae Probable transmembrane transport protein 0.0249 0.0987 0.1751
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0042 0.0103 0.0093
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0062 0.006
Schistosoma mansoni voltage-gated cation channel 0.0042 0.0103 0.0093
Brugia malayi EGF-like domain containing protein 0.046 0.1893 0.1893
Schistosoma mansoni carbonic anhydrase 0.1285 0.5436 0.5431
Loa Loa (eye worm) hypothetical protein 0.046 0.1893 0.1892
Loa Loa (eye worm) hypothetical protein 0.0043 0.0106 0.0104
Onchocerca volvulus 0.046 0.1893 0.1885
Echinococcus multilocularis GPCR, family 2 0.0033 0.0062 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0119 0.0145
Schistosoma mansoni notch 0.046 0.1893 0.1885
Loa Loa (eye worm) hypothetical protein 0.0043 0.0106 0.0104
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0034 0.0068 0.0133
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0014 0.0024
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.2349 1 1
Brugia malayi follicle stimulating hormone receptor 0.0255 0.1017 0.1017
Brugia malayi Cytochrome P450 family protein 0.0028 0.0039 0.0039
Echinococcus granulosus mitogen activated protein kinase 11 0.0136 0.0502 0.0493
Wolbachia endosymbiont of Brugia malayi 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 0.0074 0.0239 0.2761
Onchocerca volvulus 0.0255 0.1014 0.1005
Loa Loa (eye worm) hypothetical protein 0.046 0.1893 0.1892
Loa Loa (eye worm) hypothetical protein 0.0255 0.1014 0.1012
Echinococcus multilocularis carbonic anhydrase II 0.1151 0.486 0.4855
Loa Loa (eye worm) hypothetical protein 0.046 0.1893 0.1892
Schistosoma mansoni carbonic anhydrase-related 0.0556 0.2307 0.23
Leishmania major hypothetical protein, conserved 0.0042 0.0103 0.0119
Onchocerca volvulus 0.0043 0.0106 0.0097
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0255 0.1017 0.1015
Mycobacterium ulcerans carbonic anhydrase 0.1285 0.5436 0.8587
Brugia malayi EGF-like domain containing protein 0.046 0.1893 0.1893
Schistosoma mansoni membrane associated proteins in eicosanoid and glutathione metabolism family member 0.0993 0.4181 0.4175
Brugia malayi Cytochrome P450 family protein 0.0077 0.0249 0.0249
Loa Loa (eye worm) hypothetical protein 0.0071 0.0227 0.0225
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0043 0.0106 0.0097
Onchocerca volvulus Peroxidase homolog 0.2349 1 1
Echinococcus granulosus FTZ F1 alpha 0.0029 0.0046 0.0037
Schistosoma mansoni coup transcription factor 0.0029 0.0046 0.0037
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0029 0.0046 0.0037
Brugia malayi nuclear hormone receptor 0.0029 0.0046 0.0046
Schistosoma mansoni hypothetical protein 0.046 0.1893 0.1885
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0043 0.0106 0.0106
Loa Loa (eye worm) animal heme peroxidase 0.2349 1 1
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.1285 0.5436 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0046 0.0119 0.003
Loa Loa (eye worm) norepinephrine transporter 0.0255 0.1014 0.1012
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0039 0.0037
Toxoplasma gondii hypothetical protein 0.0037 0.0081 0.0058
Schistosoma mansoni cell polarity protein 0.046 0.1893 0.1885
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0078 0.0081
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0046 0.0037
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0109 0.039 1
Echinococcus multilocularis neurogenic locus notch protein 4 0.046 0.1893 0.1885
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0119 0.0167
Echinococcus granulosus carbonic anhydrase 0.0556 0.2307 0.23
Trichomonas vaginalis AGC family protein kinase 0.0304 0.1223 0.1899
Echinococcus granulosus cytochrome c oxidase subunit II 0.0157 0.0594 0.0585
Brugia malayi Animal haem peroxidase family protein 0.2349 1 1
Echinococcus granulosus neurogenic locus notch protein 4 0.046 0.1893 0.1885
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0039 0.0037
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0047 0.0124 0.0115
Echinococcus granulosus carbonic anhydrase II 0.1151 0.486 0.4855
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0043 0.0106 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1151 0.486 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0044
Onchocerca volvulus 0.0043 0.0106 0.0097
Echinococcus multilocularis voltage dependent calcium channel 0.0042 0.0103 0.0093
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP 0.0034 0.0068 0.0046
Loa Loa (eye worm) hypothetical protein 0.2349 1 1
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0079 0.0156
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0044
Echinococcus granulosus neural cadherin 0.046 0.1893 0.1885
Brugia malayi steroid hormone receptor 0.0029 0.0046 0.0046
Schistosoma mansoni sodium/chloride dependent transporter 0.0255 0.1014 0.1005
Schistosoma mansoni hypothetical protein 0.046 0.1893 0.1885
Toxoplasma gondii hypothetical protein 0.0043 0.0106 0.0172
Echinococcus multilocularis mitogen activated protein kinase 11 0.0136 0.0502 0.0493
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0044
Loa Loa (eye worm) hypothetical protein 0.2349 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0044
Brugia malayi Animal haem peroxidase family protein 0.2349 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.001 0.0008
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0043 0.0106 0.0172
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0043 0.0106 0.0106
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0029 0.0046 0.0046
Echinococcus granulosus peroxidasin 0.2349 1 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0119 0.0239
Echinococcus multilocularis ecdysone induced protein 78C 0.0029 0.0046 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0029 0.0046 0.0046
Plasmodium vivax amine transporter, putative 0.0043 0.0106 0.2534
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0044
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0043 0.0106 0.0172
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0062 0.0062
Trypanosoma brucei hypothetical protein, conserved 0.0042 0.0103 0.0206
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0133 0.049 0.048
Schistosoma mansoni sodium/chloride dependent transporter 0.0043 0.0106 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0029 0.0046 0.0046
Schistosoma mansoni steroid hormone receptor ad4bp 0.0029 0.0046 0.0037
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0029 0.0046 0.0046
Onchocerca volvulus Neurogenic locus notch protein homolog 0.046 0.1893 0.1885
Loa Loa (eye worm) hypothetical protein 0.0556 0.2307 0.2306
Loa Loa (eye worm) animal heme peroxidase 0.2349 1 1
Echinococcus multilocularis mitogen activated protein kinase 14 0.0136 0.0502 0.0493
Echinococcus multilocularis peroxidasin 0.2349 1 1
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0556 0.2307 0.2307
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.1151 0.486 0.4859
Loa Loa (eye worm) hypothetical protein 0.0043 0.0106 0.0104
Loa Loa (eye worm) hypothetical protein 0.2349 1 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0029 0.0046 0.0044
Schistosoma mansoni sodium/chloride dependent transporter 0.0047 0.0121 0.0111
Echinococcus granulosus voltage dependent calcium channel 0.0042 0.0103 0.0093
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0369 0.0369
Schistosoma mansoni hypothetical protein 0.0179 0.0687 0.0678
Brugia malayi Nuclear hormone receptor-like 1 0.0029 0.0046 0.0046
Brugia malayi Animal haem peroxidase family protein 0.2349 1 1
Echinococcus multilocularis neurogenic locus protein delta 0.046 0.1893 0.1885
Treponema pallidum sodium- and chloride- dependent transporter 0.0255 0.1014 0.5
Onchocerca volvulus 0.2349 1 1
Plasmodium falciparum transporter, putative 0.0043 0.0106 0.042
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0042 0.0103 0.0093
Brugia malayi hypothetical protein 0.0021 0.001 0.001
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0043 0.0106 0.0097
Onchocerca volvulus 0.0071 0.0226 0.0217
Schistosoma mansoni laminin gamma-3 chain 0.046 0.1893 0.1885
Brugia malayi GCC2 and GCC3 family protein 0.046 0.1893 0.1893
Onchocerca volvulus 0.046 0.1893 0.1885
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.0119 0.0109
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.0042 0.0103 0.0205
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0029 0.0046 0.0037
Brugia malayi Animal haem peroxidase family protein 0.2349 1 1
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0034 0.0068 0.0252
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0043 0.0106 0.0097
Echinococcus granulosus delta-like protein 1 0.046 0.1893 0.1885
Echinococcus granulosus neurogenic locus protein delta 0.046 0.1893 0.1885
Echinococcus multilocularis carbonic anhydrase 0.0556 0.2307 0.23
Schistosoma mansoni carbonic anhydrase 0.0556 0.2307 0.23
Onchocerca volvulus Dual oxidase homolog 0.2349 1 1
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0078 0.0254 0.0244
Brugia malayi ecdysteroid receptor 0.0029 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0044
Loa Loa (eye worm) hypothetical protein 0.0033 0.0062 0.006
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0556 0.2307 0.2307
Toxoplasma gondii transporter, cation channel family protein 0.0042 0.0103 0.0156
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0043 0.0106 0.0097
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0029 0.0046 0.0046
Echinococcus multilocularis neurogenic locus notch protein 0.046 0.1893 0.1885
Loa Loa (eye worm) hypothetical protein 0.046 0.1893 0.1892
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0029 0.0046 0.0044
Brugia malayi Animal haem peroxidase family protein 0.2349 1 1
Schistosoma mansoni slit 0.046 0.1893 0.1885
Echinococcus multilocularis 3 phosphoinositide dependent protein kinase 1 0.0304 0.1223 0.1215
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0062 0.0053
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0043 0.0106 0.0097
Schistosoma mansoni hypothetical protein 0.046 0.1893 0.1885
Onchocerca volvulus 0.046 0.1893 0.1885
Schistosoma mansoni septate junction protein 0.046 0.1893 0.1885
Echinococcus granulosus nuclear factor of activated T cells 5 0.0078 0.0254 0.0244
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0078 0.0081
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0043 0.0106 0.0106
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0249 0.0987 0.2097
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0044
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0029 0.0046 0.0037
Echinococcus granulosus voltage dependent calcium channel 0.0042 0.0103 0.0093
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0818 0.343 0.7893
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0046 0.0046
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0133 0.049 0.048
Brugia malayi Delta serrate ligand family protein 0.046 0.1893 0.1893
Toxoplasma gondii MAPEG family protein 0.0228 0.0897 0.3702
Echinococcus multilocularis sodium and chloride dependent glycine 0.0043 0.0106 0.0097
Echinococcus granulosus dynactin 5 p25 0.0074 0.0239 0.0229
Loa Loa (eye worm) hypothetical protein 0.2349 1 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0106 0.0104
Loa Loa (eye worm) hypothetical protein 0.046 0.1893 0.1892
Onchocerca volvulus 0.2349 1 1
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0119 0.0149
Echinococcus multilocularis sodium and chloride dependent glycine 0.0043 0.0106 0.0097
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0226 0.0316
Schistosoma mansoni peroxidasin 0.2349 1 1
Echinococcus multilocularis carbonic anhydrase 0.0556 0.2307 0.23
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0068 0.0064
Schistosoma mansoni hypothetical protein 0.046 0.1893 0.1885
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0068 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0039 0.0018
Echinococcus granulosus notch 0.046 0.1893 0.1885
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0046 0.0037
Loa Loa (eye worm) hypothetical protein 0.0029 0.0046 0.0044
Loa Loa (eye worm) hypothetical protein 0.0255 0.1014 0.1012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0029 0.0046 0.0044
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0043 0.0106 0.0097
Echinococcus multilocularis serotonin transporter 0.0255 0.1014 0.1005
Loa Loa (eye worm) hypothetical protein 0.2349 1 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0062 0.0053
Schistosoma mansoni RAR-like nuclear receptor 0.0029 0.0046 0.0037
Brugia malayi Calcium binding EGF domain containing protein 0.046 0.1893 0.1893
Schistosoma mansoni notch 0.046 0.1893 0.1885
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0029 0.0046 0.0046
Loa Loa (eye worm) hypothetical protein 0.046 0.1893 0.1892
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0046 0.0119 0.003
Loa Loa (eye worm) hypothetical protein 0.046 0.1893 0.1892
Loa Loa (eye worm) hypothetical protein 0.046 0.1893 0.1892
Brugia malayi hypothetical protein 0.0021 0.001 0.001
Loa Loa (eye worm) hypothetical protein 0.0255 0.1014 0.1012
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0068 0.0002
Onchocerca volvulus Chorion peroxidase homolog 0.2349 1 1
Schistosoma mansoni hypothetical protein 0.046 0.1893 0.1885
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0078 0.0081
Echinococcus granulosus 3-phosphoinositide-dependent protein kinase 1 0.0304 0.1223 0.1215
Schistosoma mansoni microsomal glutathione s-transferase 0.0228 0.0897 0.0888
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0042 0.0103 0.0093
Onchocerca volvulus Putative cubilin 0.046 0.1893 0.1885
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0043 0.0106 0.0097
Brugia malayi nuclear receptor NHR-88 0.0029 0.0046 0.0046
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0042 0.0103 0.0093
Loa Loa (eye worm) AGC/PDK1 protein kinase 0.0304 0.1223 0.1221
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0119 0.0149
Echinococcus granulosus microsomal glutathione S transferase 3 0.0228 0.0897 0.0888
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0068 0.0064
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0039 0.0037
Echinococcus granulosus neurogenic locus notch protein 0.046 0.1893 0.1885
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0043 0.0106 0.0097
Loa Loa (eye worm) steroid hormone receptor 0.0029 0.0046 0.0044
Mycobacterium ulcerans epoxide hydrolase EphA 0.0172 0.066 0.0988
Loa Loa (eye worm) hypothetical protein 0.046 0.1893 0.1892
Loa Loa (eye worm) hypothetical protein 0.046 0.1893 0.1892
Loa Loa (eye worm) Notch2 0.046 0.1893 0.1892
Loa Loa (eye worm) hypothetical protein 0.0043 0.0106 0.0104
Brugia malayi EGF-like domain containing protein 0.046 0.1893 0.1893
Echinococcus granulosus fibropellin Ia 0.046 0.1893 0.1885
Onchocerca volvulus Cytochrome c oxidase subunit 2 homolog 0.0047 0.0124 0.0115
Loa Loa (eye worm) hypothetical protein 0.2349 1 1
Mycobacterium ulcerans carbonic anhydrase 0.1492 0.6324 1
Plasmodium falciparum carbonic anhydrase 0.0556 0.2307 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0068 0.0064
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0078 0.0081
Loa Loa (eye worm) hypothetical protein 0.2349 1 1
Plasmodium falciparum cytochrome c oxidase subunit 2, putative 0.0047 0.0124 0.0498
Loa Loa (eye worm) hypothetical protein 0.046 0.1893 0.1892
Schistosoma mansoni hypothetical protein 0.046 0.1893 0.1885
Schistosoma mansoni carbonic anhydrase-related 0.0556 0.2307 0.23
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0136 0.0502 0.1028
Echinococcus multilocularis geminin 0.0179 0.0687 0.0678
Loa Loa (eye worm) blistered cuticle protein 3 0.2349 1 1
Schistosoma mansoni cytochrome-c oxidase 0.0047 0.0124 0.0115
Loa Loa (eye worm) voltage-dependent calcium channel 0.0042 0.0103 0.0101
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0046 0.0037
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.1151 0.486 1
Loa Loa (eye worm) hypothetical protein 0.2349 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0039 0.0018
Brugia malayi EGF-like domain containing protein 0.046 0.1893 0.1893
Onchocerca volvulus Neurogenic locus notch homolog 0.046 0.1894 0.1886
Schistosoma mansoni serine/threonine protein kinase 0.0304 0.1223 0.1215
Brugia malayi Putative carbonic anhydrase 5 precursor 0.1151 0.486 0.486
Loa Loa (eye worm) hypothetical protein 0.2349 1 1
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0136 0.0502 0.05
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0029 0.0046 0.0046
Brugia malayi hypothetical protein 0.0043 0.0106 0.0106
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0043 0.0106 0.0104
Schistosoma mansoni hypothetical protein 0.0556 0.2307 0.23
Echinococcus multilocularis voltage dependent calcium channel 0.0042 0.0103 0.0093
Brugia malayi P38 map kinase family protein 2 0.0136 0.0502 0.0502
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0046 0.0037
Loa Loa (eye worm) hypothetical protein 0.046 0.1893 0.1892
Trypanosoma cruzi hypothetical protein, conserved 0.0042 0.0103 0.0133
Wolbachia endosymbiont of Brugia malayi cytochrome c oxidase, subunit 2 0.0157 0.0594 1
Onchocerca volvulus 0.046 0.1893 0.1885
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0042 0.0103 0.0093
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0255 0.1014 0.1005
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0029 0.0046 0.0037
Echinococcus multilocularis carbonic anhydrase 0.0556 0.2307 0.23
Brugia malayi Peroxidasin 0.2349 1 1
Toxoplasma gondii cytochrome C oxidase subunit IIb, putative 0.0047 0.0124 0.0252
Echinococcus granulosus mitogen activated protein kinase 14 0.0136 0.0502 0.0493
Echinococcus multilocularis thyroid hormone receptor alpha 0.0162 0.0615 0.0606
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0042 0.0103 0.0093
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0043 0.0106 0.0097
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0062 0.0062
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0039 0.0073
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0079 0.0074
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0136 0.0502 0.0859

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.246 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.041 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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