Detailed information for compound 1647341

Basic information

Technical information
  • TDR Targets ID: 1647341
  • Name: 6-[(4-methoxyphenyl)-(pyrimidin-2-ylamino)met hyl]-1,3-benzodioxol-5-ol
  • MW: 351.356 | Formula: C19H17N3O4
  • H donors: 2 H acceptors: 3 LogP: 3.14 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)C(c1cc2OCOc2cc1O)Nc1ncccn1
  • InChi: 1S/C19H17N3O4/c1-24-13-5-3-12(4-6-13)18(22-19-20-7-2-8-21-19)14-9-16-17(10-15(14)23)26-11-25-16/h2-10,18,23H,11H2,1H3,(H,20,21,22)
  • InChiKey: IJLYHFDMMYWAIQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-[(4-methoxyphenyl)-(2-pyrimidinylamino)methyl]-1,3-benzodioxol-5-ol
  • NCI60_003390
  • 6-((4-methoxyphenyl)(2-pyrimidinylamino)methyl)-1,3-benzodioxol-5-ol
  • NSC368270

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus microtubule associated protein 2 0.081 0.6835 0.6834
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Schistosoma mansoni coup transcription factor 0.0023 0.0055 0.0078
Brugia malayi nuclear receptor NHR-88 0.0023 0.0055 0.0078
Leishmania major 4-coumarate:coa ligase-like protein 0.0138 0.1043 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0138 0.1043 1
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.011 0.0753
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.0147 0.1016
Entamoeba histolytica hypothetical protein 0.0084 0.058 0.5366
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Brugia malayi G protein-coupled receptor 0.0018 0.0008 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0138 0.1043 0.1461
Brugia malayi cytochrome P450 0.0017 0.0002 0.0003
Schistosoma mansoni intermediate filament proteins 0.0031 0.0126 0.018
Mycobacterium ulcerans acyl-CoA synthetase 0.004 0.0204 0.141
Brugia malayi nuclear hormone receptor 0.0023 0.0055 0.0078
Echinococcus granulosus TGF beta signal transducer SmadC 0.0019 0.0016 0.0014
Schistosoma mansoni peptidase Clp (S14 family) 0.0183 0.1431 0.209
Echinococcus multilocularis neuropeptide receptor 0.0018 0.0008 0.0006
Echinococcus multilocularis orexin receptor type 2 0.0018 0.0008 0.0006
Plasmodium vivax acetyl-CoA synthetase, putative 0.004 0.0204 0.071
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.0147 0.0145
Echinococcus granulosus dro:myosuppressin receptor 0.0018 0.0008 0.0006
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.011 0.5343
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0018 0.0008 0.0011
Schistosoma mansoni RAR-like nuclear receptor 0.0023 0.0055 0.0078
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.012 0.0888 0.8512
Echinococcus granulosus g protein coupled receptor 0.0018 0.0008 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0008 0.0006
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0044 0.0401
Loa Loa (eye worm) hypothetical protein 0.0172 0.134 0.1877
Schistosoma mansoni amine GPCR 0.0018 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0023 0.0055 0.0078
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0018 0.0008 0.0011
Schistosoma mansoni histamine h1 receptor 0.0018 0.0008 0.0008
Brugia malayi hypothetical protein 0.0084 0.058 0.0812
Trypanosoma brucei unspecified product 0.0022 0.0044 0.207
Echinococcus granulosus mothers against decapentaplegic 5 0.0019 0.0016 0.0014
Loa Loa (eye worm) hypothetical protein 0.0023 0.0055 0.0078
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0044 0.0292
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.004 0.0204 0.1935
Onchocerca volvulus Bile acid receptor homolog 0.0023 0.0055 0.0218
Echinococcus multilocularis dna polymerase eta 0.0022 0.0044 0.0042
Trichomonas vaginalis hypothetical protein 0.0036 0.0166 0.0571
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0094 0.0131
Brugia malayi Cytochrome P450 family protein 0.0028 0.0094 0.0131
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0183 0.1431 1
Trypanosoma brucei cytochrome P450, putative 0.0028 0.0094 0.4531
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0008 0.0006
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0008 0.0006
Schistosoma mansoni hypothetical protein 0.0037 0.0173 0.0249
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0034 0.0147 0.0212
Onchocerca volvulus 0.0034 0.0147 0.0643
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0023 0.0055 0.0078
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0103 0.0742 0.5181
Entamoeba histolytica hypothetical protein 0.0084 0.058 0.5366
Mycobacterium ulcerans acyl-CoA synthetase 0.004 0.0204 0.141
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0044 0.0062
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0138 0.1043 0.7283
Brugia malayi hypothetical protein 0.0018 0.0008 0.0011
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0023 0.0055 0.0078
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0044 0.207
Echinococcus multilocularis GA binding protein alpha chain 0.0084 0.0582 0.0579
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0044 0.207
Trypanosoma cruzi PAB1-binding protein , putative 0.003 0.011 0.5343
Echinococcus multilocularis neuropeptides capa receptor 0.0018 0.0008 0.0006
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0094 0.4531
Brugia malayi Cytochrome P450 family protein 0.0028 0.0094 0.0131
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Echinococcus granulosus allatostatin A receptor 0.0018 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0008 0.0008
Onchocerca volvulus 0.0138 0.1043 0.4773
Echinococcus multilocularis ecdysone induced protein 78C 0.0023 0.0055 0.0053
Schistosoma mansoni steroid hormone receptor ad4bp 0.0023 0.0055 0.0078
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0044 0.207
Echinococcus granulosus neuropeptide receptor 0.0018 0.0008 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0055 0.0078
Trichomonas vaginalis set domain proteins, putative 0.0269 0.2175 1
Brugia malayi AKH receptor 0.0018 0.0008 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0008 0.0008
Loa Loa (eye worm) MH1 domain-containing protein 0.0019 0.0016 0.0023
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0018 0.0008 0.0006
Echinococcus granulosus lamin 0.0031 0.0126 0.0123
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.004 0.0204 0.1935
Schistosoma mansoni microtubule-associated protein tau 0.081 0.6835 1
Brugia malayi ORL1-like opioid receptor 0.0018 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Echinococcus granulosus neuropeptide FF receptor 2 0.0018 0.0008 0.0006
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0023 0.0055 0.0053
Brugia malayi Dopamine receptor protein 2 0.0018 0.0008 0.0011
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.004 0.0204 0.141
Trypanosoma brucei PAB1-binding protein , putative 0.003 0.011 0.5343
Brugia malayi latrophilin 2 splice variant baaae 0.008 0.0542 0.0759
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0097 0.0694 0.6648
Mycobacterium ulcerans acyl-CoA synthetase 0.004 0.0204 0.141
Brugia malayi Serotonin receptor 0.0018 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0103 0.0742 0.104
Trypanosoma brucei acetyl-CoA synthetase, putative 0.004 0.0204 1
Brugia malayi intermediate filament protein 0.0031 0.0126 0.0176
Schistosoma mansoni smad1 5 8 and 0.0019 0.0016 0.002
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0044 0.207
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0018 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0031 0.0126 0.0176
Brugia malayi sulfakinin receptor protein 0.0018 0.0008 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0166 0.812
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0037 0.0173 0.017
Schistosoma mansoni hypothetical protein 0.0037 0.0173 0.0249
Onchocerca volvulus 0.004 0.0204 0.0903
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0147 0.0212
Brugia malayi putative neuropeptide receptor 0.0018 0.0008 0.0011
Echinococcus multilocularis neuropeptide s receptor 0.0018 0.0008 0.0006
Brugia malayi steroid hormone receptor 0.0023 0.0055 0.0078
Brugia malayi Tachykinin-like peptides receptor 99D 0.0018 0.0008 0.0011
Brugia malayi hypothetical protein 0.0018 0.0008 0.0011
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0055 0.0078
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0044 0.207
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0018 0.0008 0.0006
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0008 0.0006
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0008 0.0008
Brugia malayi hypothetical protein 0.0036 0.0166 0.0232
Brugia malayi Probable ClpP-like protease 0.0183 0.1431 0.2004
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0232
Brugia malayi larval opioid receptor 0.0018 0.0008 0.0011
Schistosoma mansoni biogenic amine receptor 0.0018 0.0008 0.0008
Schistosoma mansoni smad1 5 8 and 0.0019 0.0016 0.002
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0018 0.0008 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0023 0.0055 0.0078
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.004 0.0204 0.0201
Brugia malayi AMP-binding enzyme family protein 0.0138 0.1043 0.1461
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0023 0.0055 0.0078
Echinococcus multilocularis peptidase Clp (S14 family) 0.012 0.0888 0.0886
Brugia malayi G protein-coupled receptor F59B2.13 0.0018 0.0008 0.0011
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0018 0.0008 0.0008
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0044 0.207
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0044 0.207
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0044 0.0062
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.004 0.0204 0.1935
Echinococcus granulosus neuropeptide Y receptor 0.0018 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0117 0.0859 0.1204
Brugia malayi Cytochrome P450 family protein 0.0017 0.0002 0.0003
Brugia malayi Fli-1 protein 0.0256 0.2061 0.2888
Schistosoma mansoni hypothetical protein 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.004 0.0204 0.141
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0018 0.0008 0.0006
Schistosoma mansoni hypothetical protein 0.029 0.2351 0.3438
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0008 0.0011
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0084 0.058 0.0578
Brugia malayi Dopamine receptor protein 1 0.0018 0.0008 0.0011
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0166 0.812
Mycobacterium ulcerans acyl-CoA synthetase 0.0138 0.1043 0.7283
Brugia malayi MH2 domain containing protein 0.0019 0.0016 0.0023
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0023 0.0055 0.0078
Echinococcus multilocularis smad 0.0019 0.0016 0.0014
Echinococcus multilocularis FTZ F1 alpha 0.0023 0.0055 0.0053
Schistosoma mansoni amine GPCR 0.0018 0.0008 0.0008
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0008 0.0006
Plasmodium vivax acyl-CoA synthetase, putative 0.0103 0.0742 0.4789
Echinococcus granulosus neuropeptide receptor 0.0018 0.0008 0.0006
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 0.0028 0.0094 0.0639
Brugia malayi AMP-binding enzyme family protein 0.0138 0.1043 0.1461
Mycobacterium ulcerans acyl-CoA synthetase 0.0138 0.1043 0.7283
Mycobacterium ulcerans acyl-CoA synthetase 0.004 0.0204 0.141
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Brugia malayi Ras-related protein ypt4 0.0036 0.0166 0.0232
Loa Loa (eye worm) hypothetical protein 0.0022 0.0044 0.0062
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0023 0.0055 0.0078
Mycobacterium ulcerans acyl-CoA synthetase 0.004 0.0204 0.141
Brugia malayi hypothetical protein 0.003 0.011 0.0154
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0138 0.1043 0.1461
Onchocerca volvulus 0.0036 0.0166 0.0728
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0138 0.1043 0.7283
Leishmania major 4-coumarate:coa ligase-like protein 0.0138 0.1043 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0008 0.0006
Brugia malayi neuropeptide F receptor 0.0018 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0845 0.7137 0.7137
Echinococcus multilocularis microtubule associated protein 2 0.081 0.6835 0.6834
Onchocerca volvulus 0.0269 0.2175 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0097 0.0694 0.6648
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0183 0.1431 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0166 0.812
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0018 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0232
Brugia malayi RE15519p 0.0018 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.004 0.0204 0.1935
Echinococcus multilocularis G protein coupled receptor 139 0.0018 0.0008 0.0006
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0183 0.1431 1
Loa Loa (eye worm) AMP-binding enzyme family protein 0.004 0.0204 0.0285
Loa Loa (eye worm) AMP-binding enzyme family protein 0.004 0.0204 0.0285
Echinococcus granulosus neuropeptide Y receptor 0.0018 0.0008 0.0006
Schistosoma mansoni retinoic acid receptor RXR 0.0023 0.0055 0.0078
Brugia malayi hypothetical protein 0.0019 0.002 0.0028
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.004 0.0204 0.141
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0044 0.207
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0034 0.0147 0.0207
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.004 0.0204 0.1935
Brugia malayi AMP-binding enzyme family protein 0.004 0.0204 0.0285
Schistosoma mansoni acetyl-CoA synthetase 0.004 0.0204 0.0295
Echinococcus multilocularis rab protein 3 0.0036 0.0166 0.0164
Schistosoma mansoni neuropeptide receptor 0.0018 0.0008 0.0008
Echinococcus multilocularis lamin dm0 0.0031 0.0126 0.0123
Echinococcus granulosus g protein coupled receptor 0.0018 0.0008 0.0006
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0018 0.0008 0.0006
Echinococcus granulosus 7tm_1 domain containing protein 0.0018 0.0008 0.0006
Brugia malayi RAB, member of RAS oncogene family-like 5 0.0036 0.0166 0.0232
Brugia malayi Calcitonin receptor-like protein seb-1 0.0117 0.0859 0.1204
Loa Loa (eye worm) MH2 domain-containing protein 0.0275 0.2222 0.3114
Echinococcus multilocularis ras-related protein rab-5 0.0036 0.0166 0.0164
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Schistosoma mansoni hypothetical protein 0.0084 0.058 0.0845
Schistosoma mansoni biogenic amine receptor 0.0018 0.0008 0.0008
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0018 0.0008 0.0006
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0023 0.0055 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0023 0.0055 0.0078
Echinococcus granulosus GTP binding protein Parf 0.0036 0.0166 0.0164
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0103 0.0742 0.104
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0137 0.0134
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0023 0.0055 0.0078
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.004 0.0204 0.141
Schistosoma mansoni neuropeptide f receptor 76f 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0023 0.0055 0.0078
Echinococcus multilocularis G-protein coupled receptor, putative 0.0018 0.0008 0.0006
Echinococcus granulosus alpha 1A adrenergic receptor 0.0018 0.0008 0.0006
Schistosoma mansoni hypothetical protein 0.0018 0.0008 0.0008
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0018 0.0008 0.0006
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0044 0.207
Echinococcus multilocularis GTP binding protein Parf 0.0036 0.0166 0.0164
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.004 0.0204 0.141
Echinococcus multilocularis neuropeptide receptor 0.0018 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Trypanosoma brucei Rab-like 5, small G protein 0.0036 0.0166 0.812
Echinococcus multilocularis g-protein coupled receptor 0.0018 0.0008 0.0006
Brugia malayi photoreceptor-specific nuclear receptor 0.0023 0.0055 0.0078
Brugia malayi Steroid receptor seven-up type 2 0.0023 0.0055 0.0078
Echinococcus multilocularis GPCR, family 2 0.0037 0.0173 0.017
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0044 0.207
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0008 0.0006
Brugia malayi hypothetical protein 0.0018 0.0008 0.0011
Schistosoma mansoni ets-related 0.0256 0.2061 0.3013
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0183 0.1431 0.1429
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0147 0.0212
Loa Loa (eye worm) MH2 domain-containing protein 0.0019 0.0016 0.0023
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.0036 0.0166 0.0728
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.012 0.0888 0.6199
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0008 0.0008
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0019 0.0016 0.0014
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0094 0.0131
Echinococcus granulosus ecdysone induced protein 78C 0.0023 0.0055 0.0053
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0023 0.0055 0.0053
Loa Loa (eye worm) latrophilin receptor protein 2 0.0037 0.0173 0.0242
Echinococcus multilocularis musashi 0.0031 0.0126 0.0123
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0008 0.0006
Echinococcus multilocularis neuropeptide Y receptor 0.0018 0.0008 0.0006
Schistosoma mansoni DNA polymerase eta 0.0022 0.0044 0.0061
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0055 0.0053
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0008 0.0006
Schistosoma mansoni smad1 5 8 and 0.0019 0.0016 0.002
Onchocerca volvulus 0.004 0.0204 0.0903
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0035 0.0155 0.1469
Entamoeba histolytica hypothetical protein 0.0084 0.058 0.5366
Echinococcus granulosus orexin receptor type 2 0.0018 0.0008 0.0006
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0084 0.058 0.0578
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0023 0.0055 0.0053
Schistosoma mansoni lamin 0.0031 0.0126 0.018
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0126 0.0176
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0117 0.0859 0.1204
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0063 0.0398 0.2769
Echinococcus granulosus Smad4 0.0019 0.0016 0.0014
Loa Loa (eye worm) fli-1 protein 0.0256 0.2061 0.2888
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0044 0.207
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0008 0.0006
Loa Loa (eye worm) cytochrome P450 0.0017 0.0002 0.0003
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.004 0.0204 1
Plasmodium falciparum acyl-CoA synthetase 0.0103 0.0742 0.4789
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0018 0.0008 0.0006
Schistosoma mansoni amine GPCR 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.004 0.0204 0.141
Toxoplasma gondii hypothetical protein 0.0063 0.0398 0.2769
Brugia malayi Pre-SET motif family protein 0.0236 0.1894 0.2653
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0008 0.0006
Echinococcus granulosus dna polymerase kappa 0.0022 0.0044 0.0042
Loa Loa (eye worm) hypothetical protein 0.0023 0.0055 0.0078
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0023 0.0055 0.0053
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0018 0.0008 0.0006
Echinococcus multilocularis somatostatin receptor 0.0018 0.0008 0.0006
Brugia malayi Serotonin receptor 0.0018 0.0008 0.0011
Brugia malayi G-protein coupled receptor 0.0018 0.0008 0.0011
Onchocerca volvulus 0.0172 0.134 0.6145
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0044 0.0042
Schistosoma mansoni amine GPCR 0.0018 0.0008 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0023 0.0055 0.0078
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0845 0.7137 1
Echinococcus granulosus neuropeptide s receptor 0.0018 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Leishmania major DNA polymerase eta, putative 0.0022 0.0044 0.0401
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0183 0.1431 1
Leishmania major acetyl-CoA synthetase, putative 0.004 0.0204 0.1935
Echinococcus granulosus tachykinin peptides receptor 99D 0.0018 0.0008 0.0006
Plasmodium vivax SET domain protein, putative 0.0034 0.0147 0.0284
Loa Loa (eye worm) hypothetical protein 0.0023 0.0055 0.0078
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0044 0.0042
Schistosoma mansoni neuropeptide receptor 0.0018 0.0008 0.0008
Echinococcus multilocularis tumor protein p63 0.1177 1 1
Brugia malayi Ets-domain containing protein 0.0084 0.0582 0.0815
Echinococcus granulosus biogenic amine 5HT receptor 0.0018 0.0008 0.0006
Echinococcus granulosus g protein coupled receptor 0.0018 0.0008 0.0006
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.029 0.2351 0.235
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.004 0.0204 0.141
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0008 0.0008
Echinococcus granulosus sex peptide receptor 0.0018 0.0008 0.0006
Schistosoma mansoni neuropeptide receptor 0.0018 0.0008 0.0008
Schistosoma mansoni cellular tumor antigen P53 0.0172 0.134 0.1958
Mycobacterium ulcerans acyl-CoA synthetase 0.004 0.0204 0.141
Echinococcus multilocularis fmrfamide receptor 0.0018 0.0008 0.0006
Brugia malayi follicle stimulating hormone receptor 0.0018 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0031 0.0121 0.0169
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Echinococcus multilocularis neuropeptide FF receptor 2 0.0018 0.0008 0.0006
Brugia malayi hypothetical protein 0.0018 0.0008 0.0011
Schistosoma mansoni biogenic amine receptor 0.0018 0.0008 0.0008
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0063 0.0398 0.218
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0008 0.0008
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0044 0.207
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0018 0.0008 0.0011
Schistosoma mansoni myosin xvIII 0.0018 0.0008 0.0008
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0183 0.1431 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0044 0.207
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.004 0.0204 0.1935
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0008 0.0006
Brugia malayi hypothetical protein 0.0018 0.0008 0.0011
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0008 0.0011
Brugia malayi hypothetical protein 0.0018 0.0008 0.0011
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0138 0.1043 1
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.004 0.0204 0.1935
Echinococcus granulosus neuropeptides capa receptor 0.0018 0.0008 0.0006
Echinococcus granulosus serotonin receptor 0.0018 0.0008 0.0006
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0055 0.0053
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.004 0.0204 0.141
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0023 0.0055 0.0053
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0018 0.0008 0.0008
Trichomonas vaginalis antibiotic synthetase, putative 0.004 0.0204 0.0749
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.004 0.0204 0.0285
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0023 0.0055 0.0078
Loa Loa (eye worm) hypothetical protein 0.0138 0.1043 0.1461
Echinococcus multilocularis fmrfamide receptor 0.0018 0.0008 0.0006
Onchocerca volvulus 0.0023 0.0055 0.0218
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0008 0.0006
Entamoeba histolytica hypothetical protein 0.0084 0.058 0.5366
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0044 0.207
Entamoeba histolytica acyl-coA synthetase, putative 0.0138 0.1043 1
Echinococcus multilocularis lamin 0.0031 0.0126 0.0123
Brugia malayi putative neuropeptide receptor NPR1 0.0018 0.0008 0.0011
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0094 0.0131
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.004 0.0204 0.141
Loa Loa (eye worm) Smad1 0.0019 0.0016 0.0023
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0008 0.0008
Brugia malayi Dopamine receptor 0.0018 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Trypanosoma cruzi Rab-like 5, small G protein 0.0036 0.0166 0.812
Schistosoma mansoni transcription factor LCR-F1 0.0084 0.058 0.0845
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0023 0.0055 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0023 0.0055 0.0078
Loa Loa (eye worm) hypothetical protein 0.003 0.011 0.0154
Loa Loa (eye worm) oxidoreductase 0.004 0.0204 0.0285
Onchocerca volvulus Protein ultraspiracle homolog 0.0023 0.0055 0.0218
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0008 0.0006
Echinococcus granulosus lamin dm0 0.0031 0.0126 0.0123
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0008 0.0006
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0044 0.0061
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0018 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0008 0.0011
Echinococcus granulosus GA binding protein alpha chain 0.0084 0.0582 0.0579
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0018 0.0008 0.0008
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.004 0.0204 0.141
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0023 0.0055 0.0078
Echinococcus multilocularis thyroid hormone receptor alpha 0.0313 0.2552 0.255
Leishmania major acetyl-CoA synthetase, putative 0.004 0.0204 0.1935
Brugia malayi Ets-domain containing protein 0.0084 0.0582 0.0815
Schistosoma mansoni thyroid hormone receptor 0.0313 0.2552 0.3731
Brugia malayi MH2 domain containing protein 0.0019 0.0016 0.0023
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.085 0.7187 0.7186
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0103 0.0742 0.7114
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0008 0.0006
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.004 0.0204 0.1935
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0055 0.0078
Loa Loa (eye worm) hypothetical protein 0.0103 0.0742 0.104
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0008 0.0008
Schistosoma mansoni amine GPCR 0.0018 0.0008 0.0008
Echinococcus granulosus GPCR family 2 0.0037 0.0173 0.017
Brugia malayi MH1 domain containing protein 0.0019 0.0016 0.0023
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.004 0.0204 0.0201
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0008 0.0008
Brugia malayi hypothetical protein 0.0018 0.0008 0.0011
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0063 0.0398 0.218
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.004 0.0204 0.141
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Brugia malayi ecdysteroid receptor 0.0023 0.0055 0.0078
Mycobacterium ulcerans acetyl-CoA synthetase 0.004 0.0204 0.141
Mycobacterium ulcerans acyl-CoA synthetase 0.004 0.0204 0.141
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0236 0.1894 0.2653
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.0147 0.0212
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0008 0.0008
Leishmania major 4-coumarate:coa ligase-like protein 0.0138 0.1043 1
Schistosoma mansoni smad 0.0019 0.0016 0.002
Schistosoma mansoni alpha-1 adrenergic receptor 0.0018 0.0008 0.0008
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0084 0.0582 0.0815
Schistosoma mansoni hypothetical protein 0.0037 0.0173 0.0249
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0037 0.0173 0.0242
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0018 0.0008 0.0011
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.004 0.0204 0.1935
Loa Loa (eye worm) hypothetical protein 0.004 0.0204 0.0285
Schistosoma mansoni gabp alpha 0.0084 0.0582 0.0848
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.004 0.0204 0.1935
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0023 0.0055 0.0053
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.004 0.0204 0.141
Schistosoma mansoni hypothetical protein 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Echinococcus multilocularis neuropeptide Y receptor 0.0018 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.008 0.0542 0.0759
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0138 0.1043 0.7283
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0023 0.0055 0.0218
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0126 0.0176
Echinococcus granulosus neuropeptide receptor A26 0.0018 0.0008 0.0006
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0023 0.0055 0.0078
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Leishmania major hypothetical protein, conserved 0.0036 0.0166 0.1572
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0044 0.207
Loa Loa (eye worm) steroid hormone receptor 0.0023 0.0055 0.0078
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.004 0.0204 0.1935
Echinococcus granulosus g-protein coupled receptor 0.0018 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0037 0.0173 0.0242
Echinococcus granulosus G protein coupled receptor 139 0.0018 0.0008 0.0006
Brugia malayi Protein kinase domain containing protein 0.0845 0.7137 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0055 0.0078
Loa Loa (eye worm) transcription factor SMAD2 0.0275 0.2222 0.3114
Brugia malayi hypothetical protein 0.0018 0.0008 0.0011
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.004 0.0204 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0023 0.0055 0.0078
Onchocerca volvulus 0.004 0.0204 0.0903
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Brugia malayi Pre-SET motif family protein 0.0034 0.0147 0.0207
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0117 0.0859 0.1204
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.004 0.0204 1
Echinococcus granulosus somatostatin receptor 0.0018 0.0008 0.0006
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0183 0.1431 0.5
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0183 0.1431 1
Trichomonas vaginalis antibiotic synthetase, putative 0.004 0.0204 0.0749
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.004 0.0204 0.1935
Entamoeba histolytica hypothetical protein 0.0036 0.0166 0.122
Schistosoma mansoni thyroid hormone receptor 0.0313 0.2552 0.3731
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0023 0.0055 0.0078
Echinococcus granulosus FTZ F1 alpha 0.0023 0.0055 0.0053
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0023 0.0055 0.0078
Echinococcus multilocularis serotonin receptor 0.0018 0.0008 0.0006
Leishmania major DNA polymerase kappa, putative 0.0022 0.0044 0.0401
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0044 0.0062
Schistosoma mansoni hypothetical protein 0.008 0.0542 0.0789
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0018 0.0008 0.0006
Echinococcus granulosus hypothetical protein 0.0018 0.0008 0.0006
Brugia malayi MH1 domain containing protein 0.0019 0.0016 0.0023
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0018 0.0008 0.0006
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0018 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Schistosoma mansoni growth hormone secretagogue receptor 0.0018 0.0008 0.0008
Echinococcus granulosus dna polymerase eta 0.0022 0.0044 0.0042
Brugia malayi AMP-binding enzyme family protein 0.004 0.0204 0.0285
Onchocerca volvulus 0.004 0.0204 0.0903
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0018 0.0008 0.0011
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0008 0.0006
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.012 0.0888 0.8512
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0138 0.1043 0.7283
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.0147 0.0145
Loa Loa (eye worm) TYRA-2 protein 0.0018 0.0008 0.0011
Brugia malayi hypothetical protein 0.0018 0.0008 0.0011
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0138 0.1043 0.7283
Loa Loa (eye worm) hypothetical protein 0.0023 0.0055 0.0078
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0018 0.0008 0.0006
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.004 0.0204 0.1599
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0018 0.0008 0.0008
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0008 0.0006
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.0147 0.0145
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0044 0.207
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0044 0.0042
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0008 0.0006
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0018 0.0008 0.0008
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0018 0.0008 0.0008
Onchocerca volvulus 0.0031 0.0126 0.0542
Brugia malayi Latrophilin receptor protein 2 0.0037 0.0173 0.0242
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Echinococcus multilocularis Smad4 0.0019 0.0016 0.0014
Echinococcus granulosus 7TM GPCR rhodopsin 0.0018 0.0008 0.0006
Brugia malayi AMP-binding enzyme family protein 0.0138 0.1043 0.1461
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0044 0.0401
Mycobacterium ulcerans hypothetical protein 0.0138 0.1043 0.7283
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0023 0.0055 0.0078
Loa Loa (eye worm) hypothetical protein 0.0103 0.0742 0.104
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0183 0.1431 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0023 0.0055 0.0078
Brugia malayi G-protein coupled receptor 0.0018 0.0008 0.0011
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.004 0.0204 1
Brugia malayi Nuclear hormone receptor-like 1 0.0023 0.0055 0.0078
Loa Loa (eye worm) hypothetical protein 0.0023 0.0055 0.0078
Brugia malayi hypothetical protein 0.0018 0.0008 0.0011
Brugia malayi Cytochrome P450 family protein 0.0063 0.04 0.056
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0044 0.207
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0183 0.1431 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0138 0.1043 0.7283
Echinococcus granulosus biogenic amine 5HT receptor 0.0018 0.0008 0.0006
Schistosoma mansoni opsin-like receptor 0.0018 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Trypanosoma cruzi cytochrome P450, putative 0.0028 0.0094 0.4531
Schistosoma mansoni hypothetical protein 0.0037 0.0173 0.0249
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0044 0.0401
Loa Loa (eye worm) melatonin receptor type 1A 0.0018 0.0008 0.0011
Echinococcus multilocularis neuropeptide receptor A26 0.0018 0.0008 0.0006
Echinococcus multilocularis sex peptide receptor 0.0018 0.0008 0.0006
Brugia malayi MH2 domain containing protein 0.0275 0.2222 0.3114
Loa Loa (eye worm) hypothetical protein 0.0072 0.0476 0.0667
Brugia malayi neuropeptide F receptor 0.0018 0.0008 0.0011
Leishmania major cytochrome p450-like protein 0.0028 0.0094 0.0877
Echinococcus multilocularis allatostatin A receptor 0.0018 0.0008 0.0006
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0044 0.207
Echinococcus multilocularis mothers against decapentaplegic 5 0.0019 0.0016 0.0014
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0008 0.0006
Plasmodium falciparum ras-related protein Rab-5A 0.0036 0.0166 0.0423
Mycobacterium ulcerans acyl-CoA synthetase 0.0138 0.1043 0.7283
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0018 0.0008 0.0006
Echinococcus granulosus neuropeptides capa receptor 0.0018 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0023 0.0055 0.0078
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.004 0.0204 0.141
Schistosoma mansoni hypothetical protein 0.0018 0.0008 0.0008
Schistosoma mansoni nuclear hormone receptor 0.0023 0.0055 0.0078
Echinococcus multilocularis neuropeptides capa receptor 0.0018 0.0008 0.0006
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0023 0.0055 0.0078
Leishmania major hypothetical protein, conserved 0.0036 0.0166 0.1572
Schistosoma mansoni adenoreceptor 0.0018 0.0008 0.0008
Onchocerca volvulus 0.0031 0.0126 0.0542
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0018 0.0008 0.0008
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0044 0.0292
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0183 0.1431 1
Leishmania major hypothetical protein, conserved 0.003 0.011 0.1034
Echinococcus granulosus intermediate filament protein 0.0031 0.0126 0.0123
Giardia lamblia DINP protein human, muc B family 0.0022 0.0044 0.5
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0008 0.0006
Brugia malayi acetyl-Coenzyme A synthetase 2 0.004 0.0204 0.0285
Brugia malayi AMP-binding enzyme family protein 0.004 0.0204 0.0285
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0018 0.0008 0.0006
Echinococcus granulosus peptidase Clp S14 family 0.012 0.0888 0.0886
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0018 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Schistosoma mansoni hypothetical protein 0.0036 0.0166 0.0239
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0166 0.0571
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.029 0.2351 0.235
Echinococcus granulosus fmrfamide receptor 0.0018 0.0008 0.0006
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0018 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.004 0.0204 0.0285
Brugia malayi Melatonin receptor type 1A 0.0018 0.0008 0.0011
Schistosoma mansoni neuropeptide receptor 0.0018 0.0008 0.0008
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0037 0.0173 0.017
Brugia malayi AMP-binding enzyme family protein 0.004 0.0204 0.0285
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0019 0.0016 0.002
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0023 0.0055 0.0053
Echinococcus multilocularis dro:myosuppressin receptor 0.0018 0.0008 0.0006
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0183 0.1431 1
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0008 0.0006
Schistosoma mansoni lamin 0.0031 0.0126 0.018
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0044 0.207
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Schistosoma mansoni Smad4 0.0019 0.0016 0.002
Loa Loa (eye worm) hypothetical protein 0.0103 0.0742 0.104
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0126 0.0176
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0183 0.1431 0.1429
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0008 0.0008
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0008 0.0008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0097 0.0694 0.6648
Loa Loa (eye worm) hypothetical protein 0.0018 0.0008 0.0011
Mycobacterium ulcerans acyl-CoA synthetase 0.004 0.0204 0.141
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0023 0.0055 0.0078
Echinococcus granulosus rab protein 3 0.0036 0.0166 0.0164
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0023 0.0055 0.0053
Entamoeba histolytica hypothetical protein 0.0036 0.0166 0.122
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0023 0.0055 0.0078
Loa Loa (eye worm) cytochrome P450 family protein 0.0063 0.04 0.056
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0097 0.0694 0.6648
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0023 0.0055 0.0053
Plasmodium falciparum acetyl-CoA synthetase, putative 0.004 0.0204 0.071
Brugia malayi Smad1 0.0019 0.0016 0.0023
Entamoeba histolytica acyl-CoA synthetase, putative 0.0138 0.1043 1
Echinococcus multilocularis serotonin receptor 0.0018 0.0008 0.0006
Loa Loa (eye worm) hypothetical protein 0.0036 0.0166 0.0232
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0044 0.0061
Echinococcus granulosus smad 0.0019 0.0016 0.0014
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0008 0.0006
Schistosoma mansoni opsin-like receptor 0.0018 0.0008 0.0008
Schistosoma mansoni opsin-like receptor 0.0018 0.0008 0.0008
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0018 0.0008 0.0011
Loa Loa (eye worm) hypothetical protein 0.0183 0.1431 0.2004
Echinococcus granulosus peptide allatostatin:somatostatin 0.0018 0.0008 0.0006
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0018 0.0008 0.0008
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.004 0.0204 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0023 0.0055 0.0078
Trichomonas vaginalis GTP binding protein rare7l, putative 0.0036 0.0166 0.0571
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0008 0.0008
Toxoplasma gondii propionate-CoA ligase 0.004 0.0204 0.141
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0037 0.0173 0.017
Plasmodium vivax ras-related protein Rab-5A, putative 0.0036 0.0166 0.0423
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0018 0.0008 0.0006
Brugia malayi GnHR receptor homolog 0.0018 0.0008 0.0011
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0037 0.0173 0.017
Entamoeba histolytica acyl-CoA synthetase, putative 0.0138 0.1043 1

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.895 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.819 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.786 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.768 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.76 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.738 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.688 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.43 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.379 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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