Detailed information for compound 1651058

Basic information

Technical information
  • TDR Targets ID: 1651058
  • Name: 3-chloro-N-[1-(1,3-dioxoinden-2-yl)ethylidene amino]benzamide
  • MW: 340.76 | Formula: C18H13ClN2O3
  • H donors: 1 H acceptors: 3 LogP: 3.41 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1cccc(c1)C(=O)N/N=C(/C1C(=O)c2c(C1=O)cccc2)\C
  • InChi: 1S/C18H13ClN2O3/c1-10(20-21-18(24)11-5-4-6-12(19)9-11)15-16(22)13-7-2-3-8-14(13)17(15)23/h2-9,15H,1H3,(H,21,24)/b20-10+
  • InChiKey: DRCBFIKLMBTUCD-KEBDBYFISA-N  


Substructure search Similarity search

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Synonyms

  • 3-chloro-N-[1-(1,3-dioxoindan-2-yl)ethylideneamino]benzamide
  • 3-chloro-N-[1-(1,3-dioxo-2-indanyl)ethylideneamino]benzamide
  • 3-chloro-N-[1-(1,3-diketoindan-2-yl)ethylideneamino]benzamide
  • STK056553
  • 3-chloro-N'-[1-(1,3-dioxo-2,3-dihydro-1H-inden-2-yl)ethylidene]benzohydrazide
  • AN-329/10727034
  • MLS000702380
  • ARONIS017433
  • SMR000228538

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL No references
Homo sapiens chromobox homolog 1 Starlite/ChEMBL No references
Homo sapiens lamin A/C Starlite/ChEMBL No references
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL No references
Homo sapiens polymerase (DNA directed), eta Starlite/ChEMBL No references
Homo sapiens huntingtin Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Homo sapiens thyroid stimulating hormone receptor Starlite/ChEMBL No references
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL No references
Homo sapiens RAB9A, member RAS oncogene family Starlite/ChEMBL No references
Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble Starlite/ChEMBL No references
Homo sapiens glucagon-like peptide 1 receptor Starlite/ChEMBL No references
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Theileria parva hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania mexicana DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Echinococcus granulosus dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Plasmodium knowlesi isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania donovani isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Onchocerca volvulus Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma congolense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania braziliensis DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum DinB/family X-type DNA polymerase Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Trypanosoma brucei gambiense isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei gambiense isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Candida albicans C terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Toxoplasma gondii isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania major DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum hypothetical protein Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Chromobox protein homolog 5, putative Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Trypanosoma brucei gambiense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum ko:K03509 DNA polymerase eta subunit, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Theileria parva isocitrate dehydrogenase (NADP+), putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma mansoni chromobox protein Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma congolense DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi isocitrate dehydrogenase, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Babesia bovis isocitrate dehydrogenase, NADP-dependent family protein Get druggable targets OG5_127057 All targets in OG5_127057
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Brugia malayi follicle stimulating hormone receptor Get druggable targets OG5_130089 All targets in OG5_130089
Toxoplasma gondii ImpB/MucB/SamB family protein Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi hypothetical protein Get druggable targets OG5_132837 All targets in OG5_132837
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Candida albicans similar to S. cerevisiae DNA polymerase pol-eta, involved in the bypass of distorted DNA lesions Get druggable targets OG5_128521 All targets in OG5_128521
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis dna polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Echinococcus granulosus NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Heterochromatin protein 1 homolog Get druggable targets OG5_129545 All targets in OG5_129545
Trichomonas vaginalis chromobox protein, putative Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans N terminus of cytosolic NADP-specific isocitrate dehydrogenase. Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Neospora caninum Isocitrate dehydrogenase-like protein, related Get druggable targets OG5_127057 All targets in OG5_127057
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Plasmodium yoelii isocitrate dehydrogenase, NADP-dependent, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma mansoni DNA polymerase eta Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni NADP-specific isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Leishmania infantum DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma japonicum ko:K00031 isocitrate dehydrogenase [EC1.1.1.42], putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus granulosus chromobox protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) heterochromatin protein 1 Get druggable targets OG5_129545 All targets in OG5_129545
Echinococcus multilocularis isocitrate dehydrogenase Get druggable targets OG5_127057 All targets in OG5_127057
Onchocerca volvulus Huntingtin homolog Get druggable targets OG5_132837 All targets in OG5_132837
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma cruzi DNA polymerase eta, putative Get druggable targets OG5_128521 All targets in OG5_128521
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Plasmodium berghei isocitrate dehydrogenase [NADP], mitochondrial, putative Get druggable targets OG5_127057 All targets in OG5_127057
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana Get druggable targets OG5_128521 All targets in OG5_128521
Neospora caninum Pc21g17280 protein, related Get druggable targets OG5_128521 All targets in OG5_128521
Leishmania braziliensis isocitrate dehydrogenase [NADP], mitochondrial precursor, putative Get druggable targets OG5_127057 All targets in OG5_127057
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Plasmodium falciparum ras-related protein Rab-5B RAB9A, member RAS oncogene family 201 aa 165 aa 30.9 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Loa Loa (eye worm) pigment dispersing factor receptor c glucagon-like peptide 1 receptor 463 aa 388 aa 25.8 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni ste20-related kinase 0.0524 0.7658 1
Echinococcus multilocularis musashi 0.0033 0.0282 0.0282
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0501 0.0845
Echinococcus granulosus leucine rich repeat serine:threonine protein 0.0538 0.7875 0.7875
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0143 0.0502
Echinococcus granulosus tar DNA binding protein 0.0076 0.0942 0.0942
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0143 0.0502
Loa Loa (eye worm) hypothetical protein 0.0041 0.0411 0.0392
Brugia malayi hypothetical protein 0.0023 0.0134 0.0114
Loa Loa (eye worm) hypothetical protein 0.0023 0.0134 0.0114
Brugia malayi Ras-related protein ypt4 0.0023 0.0134 0.0114
Trichomonas vaginalis STE family protein kinase 0.0312 0.4478 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0334 0.0337
Giardia lamblia Kinase, STE STE20 0.016 0.2199 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.3566 0.3553
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0134 0.0257
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0942 0.1138
Echinococcus multilocularis rab protein 3 0.0023 0.0134 0.0134
Brugia malayi RNA recognition motif domain containing protein 0.0076 0.0942 0.0924
Onchocerca volvulus 0.0033 0.0282 0.069
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.0535 0.7821 0.7821
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0143 0.0021
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0019 0.0079 0.0079
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0143 0.0299
Schistosoma mansoni serine/threonine protein kinase 0.0165 0.2276 0.2899
Loa Loa (eye worm) hypothetical protein 0.0047 0.0501 0.0482
Echinococcus multilocularis GPCR, family 2 0.0019 0.0079 0.0079
Brugia malayi Latrophilin receptor protein 2 0.0019 0.0079 0.0059
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0942 0.1138
Toxoplasma gondii aldehyde dehydrogenase 0.0073 0.0894 1
Leishmania major DNA polymerase eta, putative 0.0038 0.0364 0.134
Brugia malayi Protein kinase domain containing protein 0.0535 0.7821 0.7816
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0942 0.1138
Onchocerca volvulus 0.0037 0.0348 0.0852
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0894 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0334 0.0337
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0143 0.0299
Echinococcus granulosus GPCR family 2 0.0019 0.0079 0.0079
Loa Loa (eye worm) hypothetical protein 0.0148 0.2014 0.1998
Loa Loa (eye worm) hypothetical protein 0.0032 0.0273 0.0253
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0143 0.0299
Entamoeba histolytica protein kinase, putative 0.0312 0.4478 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0019 0.0079 0.0079
Schistosoma mansoni chromobox protein 0.0084 0.1056 0.1289
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0073 0.0894 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.006 0.0697 0.0678
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0019 0.008 0.008
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0143 0.0502
Echinococcus granulosus chromobox protein 1 0.0084 0.1056 0.1056
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0143 0.0084
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0334 0.0334
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0073 0.0894 0.0894
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0143 0.0123
Trichomonas vaginalis STE family protein kinase 0.0312 0.4478 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0282 0.0262
Loa Loa (eye worm) hypothetical protein 0.0036 0.0334 0.0315
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0143 0.0502
Echinococcus multilocularis isocitrate dehydrogenase 0.0019 0.008 0.008
Echinococcus granulosus intermediate filament protein 0.0033 0.0282 0.0282
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0894 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.006 0.0697 0.0678
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0334 0.3128
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1056 0.2123
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0143 0.0084
Plasmodium falciparum ras-related protein Rab-5A 0.0023 0.0134 0.0124
Loa Loa (eye worm) hypothetical protein 0.0023 0.0134 0.0114
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0143 0.0502
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0315 0.0315
Schistosoma mansoni serine/threonine protein kinase 0.0312 0.4478 0.5804
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0555 0.0969
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0143 0.0502
Trypanosoma brucei Rab-like 5, small G protein 0.0023 0.0134 0.046
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0019 0.008 0.008
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0134 0.0257
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.3992 0.398
Loa Loa (eye worm) hypothetical protein 0.0054 0.0605 0.0586
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.008 0.008
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.016 0.2199 0.4753
Trichomonas vaginalis STE family protein kinase 0.016 0.2199 0.4753
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0143 0.0502
Trypanosoma cruzi Rab-like 5, small G protein 0.0023 0.0134 0.0257
Echinococcus granulosus serine threonine protein kinase 0.0312 0.4478 0.4478
Loa Loa (eye worm) TAR-binding protein 0.0076 0.0942 0.0923
Trypanosoma cruzi hypothetical protein, conserved 0.0023 0.0134 0.0257
Onchocerca volvulus 0.005 0.0541 0.1324
Brugia malayi Heterochromatin protein 1 0.0084 0.1056 0.1038
Schistosoma mansoni DNA polymerase eta 0.0054 0.0605 0.0694
Leishmania major DNA polymerase eta, putative 0.0054 0.0605 0.2479
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0038 0.0364 0.3487
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.008 0.008
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0076 0.0942 0.0923
Loa Loa (eye worm) latrophilin receptor protein 2 0.0019 0.0079 0.0059
Echinococcus granulosus geminin 0.0205 0.2865 0.2865
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0334 0.0337
Onchocerca volvulus 0.0033 0.0282 0.069
Echinococcus granulosus dna polymerase eta 0.0054 0.0605 0.0605
Plasmodium vivax serine/threonine-specific protein kinase, putative 0.0312 0.4478 1
Plasmodium vivax SET domain protein, putative 0.0036 0.0334 0.0579
Schistosoma mansoni chromobox protein 0.0084 0.1056 0.1289
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0143 0.0502
Onchocerca volvulus Huntingtin homolog 0.0148 0.2014 0.4928
Brugia malayi TAR-binding protein 0.0076 0.0942 0.0924
Loa Loa (eye worm) intermediate filament protein 0.0033 0.0282 0.0262
Echinococcus multilocularis serine threonine protein kinase 0.0312 0.4478 0.4478
Onchocerca volvulus 0.0023 0.0134 0.0328
Brugia malayi Pre-SET motif family protein 0.0251 0.3566 0.3553
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0019 0.008 0.0209
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0019 0.008 0.0209
Leishmania major DNA polymerase kappa, putative 0.0023 0.0143 0.0299
Echinococcus granulosus lamin 0.0033 0.0282 0.0282
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.068 1 1
Loa Loa (eye worm) TKL/LRRK protein kinase 0.0535 0.7821 0.7816
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0143 0.0143
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0143 0.0502
Brugia malayi Pre-SET motif family protein 0.0036 0.0334 0.0315
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.016 0.2199 1
Echinococcus granulosus lamin dm0 0.0033 0.0282 0.0282
Echinococcus granulosus chromobox protein 1 0.0084 0.1056 0.1056
Schistosoma mansoni hypothetical protein 0.0205 0.2865 0.3676
Leishmania major hypothetical protein, conserved 0.0023 0.0134 0.0257
Trichomonas vaginalis conserved hypothetical protein 0.0047 0.0501 0.0845
Echinococcus multilocularis GTP binding protein Parf 0.0023 0.0134 0.0134
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0143 0.0143
Trypanosoma cruzi DNA polymerase eta, putative 0.0038 0.0364 0.134
Brugia malayi follicle stimulating hormone receptor 0.028 0.3992 0.398
Plasmodium falciparum protein kinase, putative 0.0312 0.4478 1
Plasmodium vivax ras-related protein Rab-5A, putative 0.0023 0.0134 0.0124
Brugia malayi intermediate filament protein 0.0033 0.0282 0.0263
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0143 0.0123
Brugia malayi Isocitrate dehydrogenase 0.0019 0.008 0.006
Brugia malayi ImpB/MucB/SamB family protein 0.0054 0.0605 0.0586
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0143 0.0143
Echinococcus multilocularis serine:threonine protein kinase 3 0.068 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0143 0.0299
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0073 0.0894 0.0894
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0029 0.0029
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0019 0.0079 0.0059
Echinococcus granulosus serine:threonine protein kinase 3 0.068 1 1
Echinococcus multilocularis geminin 0.0205 0.2865 0.2865
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0334 0.0334
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0942 0.1138
Loa Loa (eye worm) pigment dispersing factor receptor c 0.006 0.0697 0.0678
Echinococcus multilocularis dna polymerase eta 0.0054 0.0605 0.0605
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0143 0.0502
Brugia malayi Protein kinase domain containing protein 0.0165 0.2276 0.2261
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.0023 0.0134 0.0328
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0143 0.0502
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0019 0.0079 0.0079
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.016 0.2199 1
Loa Loa (eye worm) heterochromatin protein 1 0.0084 0.1056 0.1038
Trichomonas vaginalis chromobox protein, putative 0.0051 0.0555 0.0969
Echinococcus multilocularis lamin dm0 0.0033 0.0282 0.0282
Echinococcus granulosus dna polymerase kappa 0.0023 0.0143 0.0143
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0143 0.0021
Brugia malayi RNA binding protein 0.0076 0.0942 0.0924
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0143 0.0779
Loa Loa (eye worm) hypothetical protein 0.0023 0.0134 0.0114
Leishmania major hypothetical protein, conserved 0.0023 0.0134 0.0257
Trypanosoma brucei DNA polymerase eta, putative 0.0054 0.0605 0.2636
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0143 0.0299
Trichomonas vaginalis set domain proteins, putative 0.0286 0.4088 0.9102
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.0282 0.0262
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0073 0.0894 0.3843
Brugia malayi latrophilin 2 splice variant baaae 0.0041 0.0411 0.0392
Echinococcus multilocularis lamin 0.0033 0.0282 0.0282
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0019 0.008 0.008
Loa Loa (eye worm) hypothetical protein 0.0019 0.0079 0.0059
Loa Loa (eye worm) RNA binding protein 0.0076 0.0942 0.0923
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0501 0.1226
Loa Loa (eye worm) hypothetical protein 0.0148 0.2014 0.1998
Brugia malayi chromobox protein homolog 3 0.0047 0.0501 0.0482
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0894 0.1075
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0143 0.0502
Echinococcus granulosus rab protein 3 0.0023 0.0134 0.0134
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.016 0.2199 0.4753
Echinococcus multilocularis chromobox protein 1 0.0084 0.1056 0.1056
Onchocerca volvulus Huntingtin homolog 0.0148 0.2014 0.4928
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0019 0.008 0.0001
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0051 0.0555 0.1358
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0165 0.2276 0.2261
Trypanosoma brucei unspecified product 0.0023 0.0143 0.0502
Brugia malayi isocitrate dehydrogenase 0.0019 0.008 0.006
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0055 0.0035
Schistosoma mansoni hypothetical protein 0.0205 0.2865 0.3676
Mycobacterium ulcerans aldehyde dehydrogenase 0.0073 0.0894 1
Schistosoma mansoni intermediate filament proteins 0.0033 0.0282 0.0268
Loa Loa (eye worm) hypothetical protein 0.006 0.0697 0.0678
Schistosoma mansoni hypothetical protein 0.0041 0.0411 0.0438
Echinococcus multilocularis myosin iiia 0.016 0.2199 0.2199
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0029 0.0029
Schistosoma mansoni lamin 0.0033 0.0282 0.0268
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0295 0.0369
Loa Loa (eye worm) STE/STE20/YSK protein kinase 0.0312 0.4478 0.4466
Trypanosoma cruzi DNA polymerase eta, putative 0.0054 0.0605 0.2479
Leishmania major protein kinase, putative 0.016 0.2199 1
Echinococcus multilocularis chromobox protein 1 0.0084 0.1056 0.1056
Schistosoma mansoni aldehyde dehydrogenase 0.0073 0.0894 0.1075
Loa Loa (eye worm) hypothetical protein 0.0037 0.0348 0.0329
Echinococcus multilocularis tar DNA binding protein 0.0076 0.0942 0.0942
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.016 0.2199 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0334 0.0334
Brugia malayi hypothetical protein 0.0148 0.2014 0.1998
Schistosoma mansoni tar DNA-binding protein 0.0076 0.0942 0.1138
Schistosoma mansoni hypothetical protein 0.0023 0.0134 0.0072
Loa Loa (eye worm) isocitrate dehydrogenase 0.0019 0.008 0.006
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.0282 0.0263
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0295 0.0369
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0055 0.0035
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0143 0.0021
Brugia malayi RAB, member of RAS oncogene family-like 5 0.0023 0.0134 0.0114
Onchocerca volvulus 0.0286 0.4088 1
Trichomonas vaginalis chromobox protein, putative 0.0084 0.1056 0.2123
Loa Loa (eye worm) hypothetical protein 0.0016 0.0029 0.0009
Schistosoma mansoni lamin 0.0033 0.0282 0.0268
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0143 0.0779
Echinococcus granulosus GTP binding protein Parf 0.0023 0.0134 0.0134
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0143 0.0502
Echinococcus multilocularis ras-related protein rab-5 0.0023 0.0134 0.0134
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0019 0.0079 0.0079
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.005 0.0541 0.061

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) 68.57 uM PubChem BioAssay. Fluorescence polarization aasay to screen for inhibitors that compete for the binding of FadD28 to a bisubstrate Measured in Biochemical System Using Plate Reader - 2147-01_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
IC50 (binding) = 40.78 um PUBCHEM_BIOASSAY: Inhibitors of Plasmodium falciparum M1- Family Alanyl Aminopeptidase (M1AAP). Inhibition of the rate of hydrolysis of fluorogenic peptide substrate (H-Leu-NHMec). Secondary screen (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.0418 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 1.5849 uM PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 1.9953 uM PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 2.8184 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 3.1623 um PUBCHEM_BIOASSAY: qHTS Assay for Rab9 Promoter Activators. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 3.6626 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 5.6234 um PUBCHEM_BIOASSAY: qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP). (Class of assay: confirmatory) [Related pubchem assays: 1482, 1471 ] ChEMBL. No reference
Potency (functional) 5.8048 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 7.9433 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Modulators of Lamin A Splicing. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.2202 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) 11.9955 uM PUBCHEM_BIOASSAY: qHTS for antagonists of the Thyroid Stimulation Hormone Receptor: Hit Validation in Primary Screen. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 12.5893 um PUBCHEM_BIOASSAY: qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 12.9953 uM PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 15.8489 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference
Potency (functional) 18.526 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 19.0115 uM PUBCHEM_BIOASSAY: qHTS for antagonists of the Thyroid Stimulation Hormone Receptor: Hit Validation in Parental Cell Line. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 19.9526 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] ChEMBL. No reference
Potency (functional) 23.9341 uM PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] ChEMBL. No reference
Potency (binding) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase). (Class of assay: confirmatory) [Related pubchem assays: 2429 (Confirmation qHTS Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2407 (Probe Development Summary for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase)), 2427 (Thermal Shift Assay for Inhibitors of HPGD (15-Hydroxyprostaglandin Dehydrogenase))] ChEMBL. No reference
Potency (functional) 28.1838 uM PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 29.0929 uM PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] ChEMBL. No reference
Potency (functional) 31.6228 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference
Potency (binding) 31.6228 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 32.6427 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] ChEMBL. No reference
Potency (functional) 44.6684 uM PubChem BioAssay. qHTS for Antagonists of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 56.2341 uM PubChem BioAssay. qHTS for Inhibitors of WRN Helicase. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23
Saccharomyces cerevisiae ChEMBL23
Homo sapiens ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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