Detailed information for compound 1652640

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 485.597 | Formula: C28H27N3O3S
  • H donors: 1 H acceptors: 2 LogP: 6.02 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)Oc1ccc(cc1)[C@H]1S[C@@H](C)C(=O)Nc2c1c(C)nn2c1ccccc1C
  • InChi: 1S/C28H27N3O3S/c1-17-7-5-6-8-24(17)31-27-25(18(2)30-31)26(35-19(3)28(32)29-27)20-9-11-22(12-10-20)34-23-15-13-21(33-4)14-16-23/h5-16,19,26H,1-4H3,(H,29,32)/t19-,26+/m0/s1
  • InChiKey: RRDPNBGQSPXBCV-AFMDSPMNSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens nuclear receptor subfamily 1, group H, member 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus ecdysone induced protein 78C nuclear receptor subfamily 1, group H, member 4 476 aa 402 aa 28.1 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus tubulin subunit TubB 0.0096 0.2845 0.4163
Echinococcus granulosus tubulin beta 4A class IVa 0.0078 0.2245 0.3286
Trypanosoma cruzi tubulin gamma chain 0.009 0.2646 0.2629
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.0838 0.2891
Loa Loa (eye worm) hypothetical protein 0.002 0.0265 0.0371
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.0083 0.2414 0.3532
Echinococcus granulosus tyrosine kinase 0.0038 0.0895 0.131
Echinococcus multilocularis Tubulin alpha 1 chain 0.0096 0.2845 0.4144
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0838 0.2891
Echinococcus granulosus single minded 2 0.0036 0.0805 0.1178
Schistosoma mansoni protein kinase 0.0015 0.0111 0.0151
Trichomonas vaginalis tubulin beta chain, putative 0.0032 0.0691 0.2371
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0265 0.0434
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.1634 1
Leishmania major alpha tubulin 0.0096 0.2845 0.2829
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0265 0.0371
Loa Loa (eye worm) hypothetical protein 0.002 0.0265 0.0371
Trypanosoma cruzi tubulin delta chain 0.0031 0.0647 0.0626
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.1116 0.1634
Echinococcus multilocularis jun protein 0.0083 0.2414 0.3511
Echinococcus multilocularis beta tubulin 0.0078 0.2245 0.3264
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0265 0.0356
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0265 0.0434
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0265 0.0384
Loa Loa (eye worm) hypothetical protein 0.0027 0.0502 0.0719
Onchocerca volvulus 0.0036 0.0805 0.179
Echinococcus multilocularis Tubulin alpha 1 chain 0.0096 0.2845 0.4144
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0032 0.0691 0.2371
Plasmodium falciparum tubulin delta chain, putative 0.0031 0.0647 0.1957
Schistosoma mansoni tubulin subunit alpha 0.0096 0.2845 0.4296
Brugia malayi Tyrosine-protein kinase abl-1 0.0126 0.3869 0.761
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0031 0.0647 0.1957
Leishmania major epsilon tubulin, putative 0.0063 0.174 0.1721
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.1634 0.2367
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0265 0.0371
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0838 0.0818
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0042 0.1033 0.3916
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.0838 0.1253
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.0838 0.0871
Brugia malayi Tubulin alpha-2 chain 0.0096 0.2845 0.557
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0265 0.0387
Trypanosoma brucei alpha tubulin, putative 0.0032 0.0691 0.0586
Echinococcus granulosus Tubulin beta 2C chain 0.0078 0.2245 0.3286
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0265 0.0384
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0042 0.1033 0.3372
Echinococcus granulosus tubulin delta chain 0.0031 0.0647 0.0946
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0015 0.0111 0.0131
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0265 0.0356
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.1634 0.1615
Echinococcus multilocularis tubulin alpha 3 chain 0.0096 0.2845 0.4144
Schistosoma mansoni coup transcription factor 0.002 0.0265 0.0384
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1634 0.246
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0042 0.1033 0.1013
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0042 0.1033 0.3916
Leishmania major beta tubulin 0.0078 0.2245 0.2228
Echinococcus multilocularis calcium dependent protein kinase 0.0015 0.0101 0.0117
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0042 0.1033 1
Trypanosoma brucei methionine aminopeptidase, putative 0.0042 0.1033 0.0932
Leishmania major beta tubulin 0.0078 0.2245 0.2228
Trichomonas vaginalis tubulin beta chain, putative 0.0096 0.2845 1
Brugia malayi tubulin alpha-2 chain 0.0096 0.2845 0.557
Echinococcus multilocularis tubulin gamma 1 chain 0.009 0.2646 0.3852
Trypanosoma cruzi beta tubulin, putative 0.0078 0.2245 0.2228
Brugia malayi bHLH-PAS transcription factor 0.0036 0.0805 0.151
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0013 0.0022 0.0032
Schistosoma mansoni tubulin subunit beta 0.0078 0.2245 0.3387
Echinococcus multilocularis peroxisome assembly protein 26 0.0096 0.2845 0.4144
Loa Loa (eye worm) tubulin gamma chain 0.009 0.2646 0.3861
Trypanosoma brucei alpha tubulin 0.0096 0.2845 0.2764
Mycobacterium ulcerans putative regulatory protein 0.0036 0.0805 0.1607
Echinococcus multilocularis tubulin delta chain 0.0031 0.0647 0.0917
Trypanosoma brucei alpha tubulin 0.0096 0.2845 0.2764
Trichomonas vaginalis tubulin alpha chain, putative 0.0032 0.0691 0.2371
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0013 0.0047 0.0051
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0015 0.0111 0.0163
Entamoeba histolytica tubulin alpha chain, putative 0.0096 0.2845 1
Echinococcus multilocularis tubulin alpha chain 0.0096 0.2845 0.4144
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0265 0.0434
Loa Loa (eye worm) tubulin beta-4 chain 0.0078 0.2245 0.3275
Giardia lamblia Beta tubulin 0.0078 0.2245 0.7273
Echinococcus multilocularis Tubulin beta 2C chain 0.0078 0.2245 0.3264
Schistosoma mansoni tubulin subunit beta 0.0078 0.2245 0.3387
Leishmania major alpha tubulin 0.0096 0.2845 0.2829
Trypanosoma brucei epsilon tubulin 0.0063 0.174 0.1647
Schistosoma mansoni hypothetical protein 0.0068 0.1886 0.2843
Trichomonas vaginalis tubulin beta chain, putative 0.0096 0.2845 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0096 0.2845 1
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0013 0.0047 0.0051
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0034 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0265 0.0434
Schistosoma mansoni tubulin subunit beta 0.0078 0.2245 0.3387
Schistosoma mansoni growth factor receptor-bound protein 0.0013 0.0047 0.0053
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0265 0.0371
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0265 0.0434
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0015 0.0111 0.0163
Loa Loa (eye worm) hypothetical protein 0.002 0.0265 0.0371
Schistosoma mansoni tubulin subunit delta 0.0031 0.0647 0.0963
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0016 0.0139 0.0193
Onchocerca volvulus 0.0065 0.1809 0.4084
Leishmania major beta tubulin 0.0078 0.2245 0.2228
Echinococcus multilocularis Tubulin beta 2C chain 0.0078 0.2245 0.3264
Echinococcus granulosus tubulin gamma 1 chain 0.009 0.2646 0.3872
Loa Loa (eye worm) methionine aminopeptidase type I 0.0042 0.1033 0.1497
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0045 0.1116 0.1607
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0042 0.1033 1
Schistosoma mansoni alpha tubulin 0.0096 0.2845 0.4296
Echinococcus multilocularis tubulin alpha 1C chain 0.0096 0.2845 0.4144
Brugia malayi protein-tyrosine kinase 0.0038 0.0895 0.1689
Echinococcus multilocularis beta tubulin 0.0078 0.2245 0.3264
Onchocerca volvulus Tyrosine kinase homolog 0.0142 0.4397 1
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0034 0.005
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0042 0.1033 0.3372
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.0838 0.1253
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0045 0.1116 0.1607
Schistosoma mansoni aryl hydrocarbon receptor 0.0048 0.1229 0.1846
Echinococcus granulosus NCK adaptor protein 0.0013 0.0047 0.0068
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0265 0.0356
Echinococcus multilocularis growth factor receptor bound protein 2 0.0013 0.0047 0.0036
Brugia malayi Tubulin alpha chain 0.0096 0.2845 0.557
Trichomonas vaginalis tubulin alpha chain, putative 0.0063 0.174 0.6085
Entamoeba histolytica tubulin alpha-1 chain 0.0096 0.2845 1
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.1634 0.557
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0265 0.0434
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.0838 0.0818
Loa Loa (eye worm) hypothetical protein 0.0122 0.3706 0.5415
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.1116 0.1634
Trichomonas vaginalis tubulin, putative 0.0032 0.0691 0.2371
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0096 0.2845 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0486 0.0695
Trichomonas vaginalis tubulin epsilon chain, putative 0.0096 0.2845 1
Brugia malayi Cam kinase protein 1 0.0015 0.0111 0.0129
Trypanosoma cruzi epsilon tubulin, putative 0.0063 0.174 0.1721
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0502 0.0719
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0045 0.1116 0.1607
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0838 0.1198
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0032 0.001
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0265 0.0387
Loa Loa (eye worm) hypoxia-induced factor 1 0.0149 0.4646 0.6794
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0265 0.0555
Trypanosoma brucei tubulin delta chain 0.0031 0.0647 0.0541
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0015 0.0111 0.0146
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0502 0.0719
Toxoplasma gondii beta-1 tubulin, putative 0.0078 0.2245 0.7807
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0064 0.1752 0.6128
Toxoplasma gondii methionine aminopeptidase 0.0042 0.1033 0.3372
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0265 0.0387
Brugia malayi Cell division protein ftsZ 0.0031 0.0647 0.1194
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0265 0.0384
Leishmania major beta tubulin 0.0078 0.2245 0.2228
Leishmania major alpha tubulin 0.0096 0.2845 0.2829
Schistosoma mansoni jun-related protein 0.0068 0.1886 0.2843
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1634 1
Trichomonas vaginalis tubulin beta chain, putative 0.0096 0.2845 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0078 0.2245 0.7877
Echinococcus granulosus jun protein 0.0083 0.2414 0.3532
Loa Loa (eye worm) tubulin alpha 2 0.0065 0.1796 0.2616
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0265 0.0356
Loa Loa (eye worm) alpha-tubulin 0.0096 0.2845 0.4153
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0265 0.0356
Trichomonas vaginalis tubulin alpha chain, putative 0.0032 0.0691 0.2371
Trichomonas vaginalis tubulin, putative 0.0058 0.1552 0.5422
Brugia malayi intermediate filament protein 0.0027 0.0502 0.0907
Loa Loa (eye worm) beta-tubulin 0.0078 0.2245 0.3275
Trichomonas vaginalis tubulin gamma chain, putative 0.0078 0.2245 0.7877
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0647 0.2213
Loa Loa (eye worm) SRC-1 0.0045 0.1116 0.162
Giardia lamblia Alpha-tubulin 0.0096 0.2845 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0094 0.2783 0.4054
Schistosoma mansoni lamin 0.0027 0.0502 0.0744
Schistosoma mansoni tyrosine kinase 0.0016 0.0139 0.0193
Brugia malayi Tubulin gamma chain 0.009 0.2646 0.5174
Echinococcus multilocularis c src tyrosine kinase 0.0016 0.0139 0.0172
Trichomonas vaginalis tubulin beta chain, putative 0.0096 0.2845 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0078 0.2245 0.3264
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0045 0.1116 0.1607
Echinococcus granulosus tubulin subunit beta 0.0078 0.2245 0.3286
Trichomonas vaginalis tubulin epsilon chain, putative 0.0031 0.0647 0.2213
Treponema pallidum methionine aminopeptidase (map) 0.0042 0.1033 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0078 0.2245 0.3264
Leishmania major protein kinase, putative 0.0013 0.0032 0.001
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0838 0.0735
Schistosoma mansoni hypothetical protein 0.0168 0.5279 0.7988
Brugia malayi hypothetical protein 0.0122 0.3706 0.7284
Echinococcus multilocularis musashi 0.0027 0.0502 0.0705
Echinococcus granulosus tyrosine protein kinase Blk 0.0038 0.0895 0.131
Leishmania major beta tubulin 0.0078 0.2245 0.2228
Leishmania major beta tubulin 0.0078 0.2245 0.2228
Trypanosoma cruzi tubulin delta chain 0.0031 0.0647 0.0626
Echinococcus granulosus tubulin alpha 0.0063 0.174 0.2546
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0117
Echinococcus multilocularis tubulin subunit beta 0.0078 0.2245 0.3264
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0265 0.0555
Schistosoma mansoni growth factor receptor-bound protein 0.0013 0.0047 0.0053
Brugia malayi hypothetical protein 0.0162 0.507 1
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0013 0.0047 0.0053
Echinococcus multilocularis tubulin subunit TubB 0.0096 0.2845 0.4144
Echinococcus granulosus Tubulin alpha 1 chain 0.0096 0.2845 0.4163
Loa Loa (eye worm) hypothetical protein 0.0064 0.1752 0.2551
Trichomonas vaginalis tubulin epsilon chain, putative 0.0078 0.2245 0.7877
Onchocerca volvulus Huntingtin homolog 0.0122 0.3706 0.8419
Brugia malayi hypoxia-induced factor 1 0.0149 0.4646 0.9156
Entamoeba histolytica tubulin family protein 0.0078 0.2245 0.7807
Onchocerca volvulus 0.0027 0.0502 0.1098
Onchocerca volvulus 0.0027 0.0502 0.1098
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0032 0.001
Schistosoma mansoni alpha tubulin 0.0096 0.2845 0.4296
Trichomonas vaginalis tubulin beta chain, putative 0.0096 0.2845 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0265 0.0387
Schistosoma mansoni lamin 0.0027 0.0502 0.0744
Loa Loa (eye worm) hypothetical protein 0.0013 0.0034 0.0033
Loa Loa (eye worm) hypothetical protein 0.0162 0.507 0.7415
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0031 0.0647 0.1957
Trichomonas vaginalis tubulin gamma chain, putative 0.0063 0.174 0.6085
Echinococcus granulosus Tubulin beta 2C chain 0.0078 0.2245 0.3286
Leishmania major alpha tubulin 0.0096 0.2845 0.2829
Loa Loa (eye worm) tubulin alpha chain 0.0096 0.2845 0.4153
Toxoplasma gondii alpha-tubulin I, putative 0.0096 0.2845 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0016 0.0139 0.0203
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0265 0.0434
Onchocerca volvulus 0.0137 0.4225 0.9607
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.0838 0.1226
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.0083 0.2414 0.3511
Echinococcus granulosus tyrosine protein kinase HCK 0.0032 0.0668 0.0977
Trypanosoma brucei tubulin gamma chain 0.009 0.2646 0.2563
Brugia malayi Tubulin beta chain 0.0032 0.0691 0.1283
Mycobacterium ulcerans methionine aminopeptidase 0.0042 0.1033 0.3916
Plasmodium vivax tubulin beta chain, putative 0.0078 0.2245 0.7807
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0032 0.001
Brugia malayi PAS domain containing protein 0.0048 0.1229 0.2354
Schistosoma mansoni nck2/grb4 0.0013 0.0047 0.0053
Echinococcus multilocularis Tubulin alpha 1 chain 0.0096 0.2845 0.4144
Leishmania major alpha tubulin 0.0096 0.2845 0.2829
Leishmania major beta tubulin 0.0078 0.2245 0.2228
Giardia lamblia Gamma tubulin 0.009 0.2646 0.9094
Trypanosoma brucei zeta tubulin 0.0308 1 1
Leishmania major gamma-tubulin 0.009 0.2646 0.2629
Plasmodium vivax tubulin gamma chain, putative 0.009 0.2646 0.9271
Brugia malayi nuclear hormone receptor 0.002 0.0265 0.0434
Echinococcus granulosus Tubulin alpha 1 chain 0.0096 0.2845 0.4163
Plasmodium falciparum tubulin gamma chain 0.009 0.2646 0.9271
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.0838 0.1575
Trypanosoma brucei beta tubulin 0.0078 0.2245 0.2158
Toxoplasma gondii methionine aminopeptidase 0.0042 0.1033 0.3372
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0265 0.0434
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0265 0.0434
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0042 0.1033 0.1485
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0265 0.0384
Echinococcus granulosus c src tyrosine kinase 0.0016 0.0139 0.0203
Leishmania major alpha tubulin 0.0096 0.2845 0.2829
Echinococcus multilocularis NCK adaptor protein 0.0013 0.0047 0.0036
Leishmania major alpha tubulin 0.0096 0.2845 0.2829
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0838 0.1198
Echinococcus granulosus lamin 0.0027 0.0502 0.0735
Loa Loa (eye worm) hypothetical protein 0.0013 0.0022 0.0015
Echinococcus multilocularis transfer RNA-Lys 0.0036 0.0805 0.115
Trypanosoma cruzi epsilon tubulin, putative 0.0063 0.174 0.1721
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.0838 0.0818
Schistosoma mansoni adapter molecule crk 0.0013 0.0047 0.0053
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0015 0.0111 0.0129
Trypanosoma brucei beta tubulin 0.0078 0.2245 0.2158
Schistosoma mansoni hypothetical protein 0.0168 0.5279 0.7988
Trypanosoma brucei zeta tubulin, putative 0.0308 1 1
Brugia malayi tubulin alpha chain - mouse 0.0096 0.2845 0.557
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0265 0.0356
Schistosoma mansoni tubulin subunit gamma 0.009 0.2646 0.3994
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0042 0.1033 1
Echinococcus multilocularis tyrosine protein kinase Blk 0.0038 0.0895 0.1282
Echinococcus granulosus tubulin alpha chain 0.0096 0.2845 0.4163
Loa Loa (eye worm) hypothetical protein 0.0065 0.1796 0.2616
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0265 0.0434
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0045 0.1116 0.1607
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0265 0.0434
Brugia malayi alpha-tubulin 0.0096 0.2845 0.557
Echinococcus granulosus tubulin alpha chain 0.0096 0.2845 0.4163
Plasmodium falciparum alpha tubulin 2 0.0096 0.2845 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0015 0.0111 0.0163
Leishmania major beta tubulin 0.0078 0.2245 0.2228
Schistosoma mansoni tubulin subunit beta 0.0078 0.2245 0.3387
Plasmodium falciparum alpha tubulin 1 0.0096 0.2845 1
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0015 0.0111 0.0146
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0042 0.1033 0.3372
Echinococcus granulosus tubulin alpha 3 chain 0.0096 0.2845 0.4163
Echinococcus granulosus tubulin alpha 3 chain 0.0096 0.2845 0.4163
Trichomonas vaginalis tubulin, putative 0.0032 0.0691 0.2371
Onchocerca volvulus Huntingtin homolog 0.0122 0.3706 0.8419
Loa Loa (eye worm) tubulin alpha 2 0.0033 0.0703 0.1014
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0265 0.0384
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0042 0.1033 0.1013
Mycobacterium leprae cell division protein FtsZ 0.0031 0.0647 0.6177
Loa Loa (eye worm) hypothetical protein 0.0122 0.3706 0.5415
Schistosoma mansoni hypothetical protein 0.0051 0.1332 0.2002
Entamoeba histolytica tubulin gamma chain 0.009 0.2646 0.9271
Echinococcus granulosus roundabout 2 0.0015 0.0091 0.0134
Loa Loa (eye worm) hypothetical protein 0.0081 0.2336 0.3408
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.1116 0.1607
Echinococcus multilocularis tubulin alpha chain 0.0096 0.2845 0.4144
Echinococcus multilocularis geminin 0.0168 0.5279 0.7719
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0078 0.2245 0.3264
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0265 0.0434
Echinococcus granulosus tyrosine protein kinase ABL1 0.0214 0.6833 1
Echinococcus granulosus aryl hydrocarbon receptor 0.0013 0.0022 0.0032
Echinococcus granulosus Tubulin beta 2C chain 0.0078 0.2245 0.3286
Schistosoma mansoni single-minded 0.0048 0.1229 0.1846
Loa Loa (eye worm) BEN-1 protein 0.0078 0.2245 0.3275
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.0838 0.2891
Schistosoma mansoni protein kinase 0.0015 0.0111 0.0151
Echinococcus granulosus calcium dependent protein kinase 0.0015 0.0101 0.0148
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0012 0.0012 0.0017
Echinococcus multilocularis tyrosine protein kinase Srms 0.0038 0.0895 0.1282
Echinococcus granulosus tyrosine protein kinase Src42A 0.0036 0.0803 0.1175
Leishmania major delta tubulin, putative 0.0031 0.0647 0.0626
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1634 1
Echinococcus multilocularis tubulin beta 1 chain 0.0078 0.2245 0.3264
Echinococcus granulosus Tubulin beta 2C chain 0.0078 0.2245 0.3286
Leishmania major alpha tubulin 0.0096 0.2845 0.2829
Schistosoma mansoni tubulin subunit beta 0.0078 0.2245 0.3387
Chlamydia trachomatis methionine aminopeptidase 0.0042 0.1033 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0094 0.2783 0.5447
Loa Loa (eye worm) tubulin alpha-3 chain 0.0064 0.1752 0.2551
Toxoplasma gondii alpha tubulin TUBA1 0.0096 0.2845 1
Schistosoma mansoni nuclear hormone receptor 0.002 0.0265 0.0384
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0014 0.0082 0.0104
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0042 0.1033 0.1512
Echinococcus multilocularis tubulin alpha chain 0.0096 0.2845 0.4144
Echinococcus granulosus tyrosine protein kinase Lyn 0.0045 0.1127 0.1649
Echinococcus granulosus intermediate filament protein 0.0027 0.0502 0.0735
Loa Loa (eye worm) hypothetical protein 0.002 0.0265 0.0371
Leishmania major alpha tubulin 0.0096 0.2845 0.2829
Schistosoma mansoni tubulin subunit beta 0.0031 0.0647 0.0963
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0065 0.1796 0.6286
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0502 0.0907
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.1634 0.2391
Trypanosoma brucei beta tubulin 0.0078 0.2245 0.2158
Loa Loa (eye worm) hypothetical protein 0.0015 0.0091 0.0117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0265 0.0371
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0265 0.0434
Schistosoma mansoni tubulin subunit epsilon 0.0063 0.174 0.262
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0647 0.2213
Echinococcus multilocularis tubulin alpha 1C chain 0.0096 0.2845 0.4144
Schistosoma mansoni serine/threonine protein kinase 0.0015 0.0111 0.0151
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0265 0.0356
Brugia malayi Methionine aminopeptidase protein type I 0.0042 0.1033 0.1964
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0015 0.0111 0.0163
Brugia malayi steroid hormone receptor 0.002 0.0265 0.0434
Plasmodium vivax delta tubulin, putative 0.0031 0.0647 0.1957
Schistosoma mansoni tyrosine kinase 0.0045 0.1116 0.1675
Schistosoma mansoni tubulin subunit alpha 0.0096 0.2845 0.4296
Plasmodium falciparum tubulin beta chain 0.0078 0.2245 0.7807
Loa Loa (eye worm) alpha-tubulin 0.0096 0.2845 0.4153
Leishmania major beta tubulin 0.0078 0.2245 0.2228
Loa Loa (eye worm) hypothetical protein 0.002 0.0265 0.0371
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0214 0.6833 1
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.0838 0.1226
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0045 0.1116 0.1607
Trichomonas vaginalis tubulin beta chain, putative 0.0096 0.2845 1
Echinococcus granulosus tubulin epsilon chain 0.0063 0.174 0.2546
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0038 0.0895 0.131
Leishmania major beta tubulin 0.0078 0.2245 0.2228
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0009
Loa Loa (eye worm) hypothetical protein 0.0081 0.2334 0.3405
Schistosoma mansoni tubulin subunit alpha 0.0031 0.0647 0.0963
Loa Loa (eye worm) hypothetical protein 0.002 0.0265 0.0371
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0042 0.1033 0.0932
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0045 0.1116 0.1634
Trichomonas vaginalis tubulin gamma chain, putative 0.009 0.2646 0.9295
Echinococcus multilocularis lamin dm0 0.0027 0.0502 0.0705
Giardia lamblia Alpha-tubulin 0.0096 0.2845 1
Leishmania major beta tubulin 0.0078 0.2245 0.2228
Schistosoma mansoni thyroid hormone receptor 0.002 0.0265 0.0384
Plasmodium vivax tubulin alpha chain, putative 0.0096 0.2845 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.2845 0.4153
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0013 0.0022 0.0015
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0152 0.4731 0.6919
Trypanosoma cruzi zeta tubulin, putative 0.0308 1 1
Schistosoma mansoni tyrosine kinase 0.0016 0.0139 0.0193
Echinococcus granulosus Tubulin alpha 1 chain 0.0096 0.2845 0.4163
Trypanosoma brucei beta tubulin 0.0063 0.174 0.1647
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0265 0.0384
Loa Loa (eye worm) tubulin alpha 2 0.0065 0.1796 0.2616
Echinococcus granulosus beta tubulin 0.0078 0.2245 0.3286
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0031 0.0647 0.2213
Echinococcus multilocularis tubulin alpha 0.0063 0.174 0.2522
Echinococcus granulosus tubulin alpha chain 0.0096 0.2845 0.4163
Trypanosoma brucei beta tubulin 0.0078 0.2245 0.2158
Trypanosoma brucei epsilon tubulin 0.0063 0.174 0.1647
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0015 0.0111 0.0131
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0265 0.0434
Trypanosoma brucei alpha tubulin 0.0096 0.2845 0.2764
Brugia malayi cytoplasmic intermediate filament protein 0.0014 0.0082 0.0071
Echinococcus multilocularis tyrosine protein kinase HCK 0.0032 0.0668 0.0948
Echinococcus multilocularis tubulin epsilon chain 0.0063 0.174 0.2522
Loa Loa (eye worm) tubulin beta chain 0.0031 0.0647 0.0931
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.0838 0.1198
Leishmania major protein kinase, putative 0.0015 0.0111 0.009
Plasmodium vivax tubulin alpha chain, putative 0.0096 0.2845 1
Brugia malayi nuclear receptor NHR-88 0.002 0.0265 0.0434
Loa Loa (eye worm) hypothetical protein 0.002 0.0265 0.0371
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0265 0.0384
Loa Loa (eye worm) TK/ABL protein kinase 0.0214 0.6833 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0031 0.0647 0.2213
Schistosoma mansoni tubulin subunit beta 0.0078 0.2245 0.3387
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0265 0.0387
Brugia malayi Tubulin alpha-2 chain 0.0096 0.2845 0.557
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0265 0.0387
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0042 0.1033 0.3372
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0013 0.0032 0.001
Loa Loa (eye worm) tubulin alpha chain 0.0096 0.2845 0.4153
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0265 0.0387
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0036 0.0803 0.1147
Loa Loa (eye worm) tubulin alpha-2 chain 0.0096 0.2845 0.4153
Brugia malayi beta-tubulin, identical 0.0078 0.2245 0.4377
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0042 0.1033 0.1013
Entamoeba histolytica tubulin family protein 0.0078 0.2245 0.7807
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0265 0.0356
Trichomonas vaginalis tubulin, putative 0.0078 0.2245 0.7877
Echinococcus granulosus tubulin alpha chain 0.0096 0.2845 0.4163
Trichomonas vaginalis tubulin alpha chain, putative 0.0078 0.2245 0.7877
Brugia malayi Immunoglobulin I-set domain containing protein 0.0152 0.4731 0.9326
Schistosoma mansoni tubulin subunit alpha 0.0096 0.2845 0.4296
Onchocerca volvulus 0.002 0.0265 0.0555
Leishmania major protein kinase, putative 0.0013 0.0032 0.001
Trypanosoma cruzi alpha tubulin, putative 0.0096 0.2845 0.2829
Leishmania major alpha tubulin 0.0096 0.2845 0.2829
Echinococcus granulosus tyrosine protein kinase Fyn 0.0045 0.1116 0.1634
Brugia malayi hypothetical protein 0.0065 0.1809 0.3508
Loa Loa (eye worm) hypothetical protein 0.002 0.0265 0.0371
Leishmania major beta tubulin 0.0078 0.2245 0.2228
Loa Loa (eye worm) tubulin beta-2A chain 0.0078 0.2245 0.3275
Echinococcus multilocularis tubulin alpha chain 0.0096 0.2845 0.4144
Trichomonas vaginalis CAMK family protein kinase 0.0015 0.0111 0.0317
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0265 0.0434
Loa Loa (eye worm) TK protein kinase 0.0032 0.0668 0.0962
Echinococcus granulosus tubulin beta 1 chain 0.0078 0.2245 0.3286
Brugia malayi Tubulin alpha chain 0.0031 0.0647 0.1194
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0042 0.1033 0.1485
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0265 0.0384
Schistosoma mansoni tyrosine kinase 0.0207 0.6606 1
Leishmania major beta tubulin 0.0078 0.2245 0.2228
Echinococcus multilocularis tubulin alpha 3 chain 0.0096 0.2845 0.4144
Toxoplasma gondii beta-tubulin, putative 0.0078 0.2245 0.7807
Brugia malayi ecdysteroid receptor 0.002 0.0265 0.0434
Brugia malayi Tubulin beta-1 chain 0.0078 0.2245 0.4377
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.0838 0.1226
Leishmania major alpha tubulin 0.0096 0.2845 0.2829
Leishmania major beta tubulin 0.0078 0.2245 0.2228
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0038 0.0895 0.1282
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0042 0.1033 0.3916
Leishmania major beta tubulin 0.0078 0.2245 0.2228
Trypanosoma cruzi zeta tubulin, putative 0.0308 1 1
Toxoplasma gondii beta tubulin 0.0078 0.2245 0.7807
Leishmania major beta tubulin 0.0078 0.2245 0.2228
Schistosoma mansoni protein kinase 0.0015 0.0111 0.0151
Loa Loa (eye worm) hypothetical protein 0.0013 0.0047 0.0051
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0042 0.1033 0.0932
Echinococcus granulosus FTZ F1 alpha 0.002 0.0265 0.0387
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.1634 0.246
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0265 0.0371
Echinococcus multilocularis lamin 0.0027 0.0502 0.0705
Trypanosoma brucei epsilon tubulin 0.0063 0.174 0.1647
Echinococcus multilocularis Tubulin beta 2C chain 0.0078 0.2245 0.3264
Brugia malayi Tubulin beta chain 0.0031 0.0647 0.1194
Schistosoma mansoni intermediate filament proteins 0.0027 0.0502 0.0744
Loa Loa (eye worm) tubulin beta-1 chain 0.0078 0.2245 0.3275
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0045 0.1116 0.1634
Schistosoma mansoni thyroid hormone receptor 0.002 0.0265 0.0384
Echinococcus multilocularis tubulin alpha chain 0.0096 0.2845 0.4144
Plasmodium falciparum tubulin epsilon chain, putative 0.0063 0.174 0.5957
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0265 0.0371
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0265 0.0371
Loa Loa (eye worm) cytochrome P450 family protein 0.0026 0.0475 0.0679
Brugia malayi Cytochrome P450 family protein 0.0026 0.0475 0.0853
Loa Loa (eye worm) hypothetical protein 0.0037 0.0838 0.1211
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.0838 0.2658
Loa Loa (eye worm) hypothetical protein 0.0015 0.0111 0.0146
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.1116 0.1607
Leishmania major alpha tubulin 0.0096 0.2845 0.2829
Echinococcus granulosus peroxisome assembly protein 26 0.0096 0.2845 0.4163
Entamoeba histolytica protein kinase, putative 0.0032 0.0668 0.2036
Trichomonas vaginalis tubulin beta chain, putative 0.0078 0.2245 0.7877
Echinococcus multilocularis hypothetical protein 0.0096 0.2845 0.4144
Echinococcus granulosus tyrosine protein kinase Src42A 0.0045 0.1116 0.1634
Loa Loa (eye worm) BEN-1 protein 0.0078 0.2245 0.3275
Echinococcus granulosus Tubulin beta 2C chain 0.0078 0.2245 0.3286
Plasmodium vivax tubulin epsilon chain, putative 0.0063 0.174 0.5957
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0265 0.0371
Trichomonas vaginalis tubulin alpha chain, putative 0.0032 0.0691 0.2371
Schistosoma mansoni alpha tubulin 0.0096 0.2845 0.4296
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0065 0.1796 0.2616
Echinococcus granulosus tyrosine protein kinase Src64B 0.0045 0.1116 0.1634
Loa Loa (eye worm) TK protein kinase 0.0038 0.0895 0.1295
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0015 0.0111 0.0131
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0042 0.1033 0.3372
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0042 0.1033 0.1549
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0265 0.0434
Echinococcus granulosus lamin dm0 0.0027 0.0502 0.0735
Schistosoma mansoni tyrosine kinase 0.0045 0.1116 0.1675
Echinococcus granulosus beta tubulin 0.0078 0.2245 0.3286
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0045 0.1116 0.1607
Onchocerca volvulus 0.0032 0.0691 0.1529
Echinococcus multilocularis roundabout 2 0.0015 0.0091 0.0102
Giardia lamblia Beta tubulin 0.0078 0.2245 0.7273
Echinococcus granulosus tubulin alpha chain 0.0096 0.2845 0.4163
Trypanosoma brucei alpha tubulin 0.0096 0.2845 0.2764
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0265 0.0387
Giardia lamblia Beta tubulin 0.0078 0.2245 0.7273
Echinococcus granulosus tubulin alpha 1C chain 0.0096 0.2845 0.4163
Echinococcus granulosus tubulin alpha 1C chain 0.0096 0.2845 0.4163
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0265 0.0384
Echinococcus granulosus growth factor receptor bound protein 2 0.0013 0.0047 0.0068
Leishmania major beta tubulin 0.0078 0.2245 0.2228
Loa Loa (eye worm) tubulin beta chain 0.0078 0.2245 0.3275
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0063 0.174 0.5957
Brugia malayi SRC-1 0.0045 0.1116 0.213
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0265 0.0555
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0042 0.1033 0.1549
Leishmania major beta tubulin 0.0078 0.2245 0.2228
Echinococcus granulosus geminin 0.0168 0.5279 0.7726
Brugia malayi bZIP transcription factor family protein 0.0083 0.2414 0.4712
Loa Loa (eye worm) hypothetical protein 0.0012 0.0018 0.0009
Echinococcus granulosus alpha tubulin 0.0096 0.2845 0.4163
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0265 0.0356
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.1634 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0015 0.0111 0.0131
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0016 0.0139 0.0172

Activities

Activity type Activity value Assay description Source Reference
EC50 (binding) = 2.2 uM Agonist activity at human GST-tagged FXR ligand binding domain assessed as recruitment of Src-1 peptide after 30 mins by AlphaScreen assay ChEMBL. 22564381
Efficacy (binding) = 70 % Agonist activity at human GST-tagged FXR ligand binding domain assessed as recruitment of Src-1 peptide after 30 mins by AlphaScreen assay relative to 10 uM of CDCA ChEMBL. 22564381

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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