Detailed information for compound 1654896

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 568.787 | Formula: C34H52N2O5
  • H donors: 0 H acceptors: 2 LogP: 7.42 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cccc(c1)N1CCN(CC1)CC(=O)OCC[C@H](CC[C@H]1C(=C)CC[C@@H]2[C@]1(C)CCC[C@]2(C)C(=O)OC)C
  • InChi: 1S/C34H52N2O5/c1-25(11-13-29-26(2)12-14-30-33(29,3)16-8-17-34(30,4)32(38)40-6)15-22-41-31(37)24-35-18-20-36(21-19-35)27-9-7-10-28(23-27)39-5/h7,9-10,23,25,29-30H,2,8,11-22,24H2,1,3-6H3/t25-,29-,30+,33+,34-/m0/s1
  • InChiKey: MGJVPVDDLGZEKT-FRAFAOTQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0014 0.0057 0.0051
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0065 0.1642 0.2403
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0017 0.0138 0.0201
Giardia lamblia Beta tubulin 0.0084 0.2253 0.7273
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.004 0.0847 0.0871
Onchocerca volvulus Tyrosine kinase homolog 0.0153 0.4403 1
Echinococcus granulosus tubulin gamma 1 chain 0.0097 0.2653 0.3881
Schistosoma mansoni growth factor receptor-bound protein 0.0014 0.0057 0.0086
Leishmania major beta tubulin 0.0084 0.2253 0.2228
Trypanosoma cruzi beta tubulin, putative 0.0084 0.2253 0.2228
Chlamydia trachomatis methionine aminopeptidase 0.0046 0.1042 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.1642 1
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0512 0.0907
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.004 0.0847 0.124
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0847 0.2891
Leishmania major beta tubulin 0.0084 0.2253 0.2228
Loa Loa (eye worm) beta-tubulin 0.0084 0.2253 0.3275
Brugia malayi SRC-1 0.0048 0.1126 0.213
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0057 0.1404 0.1376
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0048 0.1126 0.1647
Echinococcus granulosus Tubulin alpha 1 chain 0.0103 0.2852 0.4172
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0059 0.0027
Echinococcus granulosus beta tubulin 0.0084 0.2253 0.3296
Trypanosoma brucei beta tubulin 0.0084 0.2253 0.2145
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0038 0.0812 0.1188
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.1642 0.2485
Loa Loa (eye worm) tubulin alpha 2 0.0035 0.0713 0.1014
Brugia malayi Tubulin alpha chain 0.0033 0.0656 0.1194
Trichomonas vaginalis tubulin alpha chain, putative 0.0035 0.0701 0.2371
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0847 0.0818
Onchocerca volvulus 0.007 0.1817 0.4084
Loa Loa (eye worm) alpha-tubulin 0.0103 0.2852 0.4153
Loa Loa (eye worm) TK protein kinase 0.0041 0.0904 0.1295
Leishmania major alpha tubulin 0.0103 0.2852 0.2829
Echinococcus granulosus tubulin alpha chain 0.0103 0.2852 0.4172
Echinococcus multilocularis geminin 0.0181 0.5284 0.773
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.004 0.0847 0.1282
Leishmania major alpha tubulin 0.0103 0.2852 0.2829
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.1126 0.1647
Leishmania major protein kinase, putative 0.0017 0.0138 0.0106
Echinococcus granulosus alpha tubulin 0.0103 0.2852 0.4172
Echinococcus multilocularis tubulin delta chain 0.0033 0.0656 0.096
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0033 0.0656 0.1909
Echinococcus multilocularis tubulin subunit TubB 0.0103 0.2852 0.4172
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0017 0.0149 0.0225
Schistosoma mansoni hypothetical protein 0.0073 0.1895 0.2866
Leishmania major beta tubulin 0.0084 0.2253 0.2228
Brugia malayi beta-tubulin, identical 0.0084 0.2253 0.4377
Echinococcus granulosus peroxisome assembly protein 26 0.0103 0.2852 0.4172
Echinococcus multilocularis mitogen activated protein kinase 0.0057 0.1404 0.2054
Leishmania major beta tubulin 0.0084 0.2253 0.2228
Entamoeba histolytica tubulin alpha-1 chain 0.0103 0.2852 1
Schistosoma mansoni hypothetical protein 0.0181 0.5284 0.7995
Echinococcus granulosus lamin 0.0029 0.0512 0.0749
Plasmodium vivax methionine aminopeptidase 1b, putative 0.0046 0.1042 0.3332
Brugia malayi Tyrosine-protein kinase abl-1 0.0136 0.3876 0.761
Loa Loa (eye worm) aryl Hydrocarbon receptor Associated protein family member 0.0014 0.0032 0.0015
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.1404 0.4865
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.007 0.1805 0.6286
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.1126 0.1647
Plasmodium falciparum alpha tubulin 1 0.0103 0.2852 1
Trichomonas vaginalis tubulin beta-1 chain, putative 0.0033 0.0656 0.2213
Leishmania major methionine aminopeptidase, putative,metallo-peptidase, Clan MG, Family M24 0.0046 0.1042 0.1013
Trichomonas vaginalis tubulin alpha chain, putative 0.0035 0.0701 0.2371
Brugia malayi bHLH-PAS transcription factor 0.0038 0.0815 0.151
Treponema pallidum methionine aminopeptidase (map) 0.0046 0.1042 1
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0048 0.1126 0.1647
Echinococcus granulosus tyrosine protein kinase ABL1 0.0231 0.6836 1
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0046 0.1042 0.1577
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0231 0.6836 1
Brugia malayi Methionine aminopeptidase protein type I 0.0046 0.1042 0.1964
Echinococcus granulosus ubiquitin specific protease 41 0.004 0.0847 0.124
Onchocerca volvulus 0.0029 0.0512 0.1098
Loa Loa (eye worm) hypothetical protein 0.007 0.1805 0.2616
Schistosoma mansoni lamin 0.0029 0.0512 0.0775
Echinococcus granulosus tubulin subunit beta 0.0084 0.2253 0.3296
Brugia malayi Tubulin beta chain 0.0033 0.0656 0.1194
Echinococcus granulosus tyrosine protein kinase Lyn 0.0049 0.1152 0.1685
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.004 0.0847 0.0818
Leishmania major beta tubulin 0.0084 0.2253 0.2228
Plasmodium falciparum methionine aminopeptidase 1a, putative 0.0046 0.1042 0.3332
Toxoplasma gondii alpha tubulin TUBA1 0.0103 0.2852 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0102 0.0117
Plasmodium vivax tubulin gamma chain, putative 0.0097 0.2653 0.9267
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0512 0.0719
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPB (MAP) (PEPTIDASE M) 0.0046 0.1042 1
Loa Loa (eye worm) hypothetical protein 0.0131 0.3712 0.5415
Schistosoma mansoni tyrosine kinase 0.0223 0.6609 1
Echinococcus granulosus tubulin alpha 0.0068 0.1748 0.2557
Leishmania major alpha tubulin 0.0103 0.2852 0.2829
Onchocerca volvulus Huntingtin homolog 0.0131 0.3712 0.8419
Schistosoma mansoni tyrosine kinase 0.0017 0.0149 0.0225
Echinococcus multilocularis tubulin beta 1 chain 0.0084 0.2253 0.3296
Trypanosoma brucei zeta tubulin 0.0331 1 1
Loa Loa (eye worm) hypothetical protein 0.0087 0.2344 0.3408
Echinococcus multilocularis tubulin alpha 1C chain 0.0103 0.2852 0.4172
Leishmania major delta tubulin, putative 0.0033 0.0656 0.0626
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0017 0.0138 0.017
Schistosoma mansoni tubulin subunit beta 0.0084 0.2253 0.3409
Echinococcus multilocularis Tubulin alpha 1 chain 0.0103 0.2852 0.4172
Schistosoma mansoni hypothetical protein 0.0055 0.1341 0.2029
Leishmania major alpha tubulin 0.0103 0.2852 0.2829
Mycobacterium leprae cell division protein FtsZ 0.0033 0.0656 0.6177
Loa Loa (eye worm) tubulin alpha-3 chain 0.0069 0.176 0.2551
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription factor 0.009 0.2421 0.3542
Entamoeba histolytica tubulin family protein 0.0084 0.2253 0.7794
Schistosoma mansoni growth factor receptor-bound protein 0.0014 0.0057 0.0086
Brugia malayi protein-tyrosine kinase 0.0041 0.0904 0.1689
Schistosoma mansoni tubulin subunit alpha 0.0103 0.2852 0.4315
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0048 0.1126 0.1647
Loa Loa (eye worm) tubulin beta chain 0.0084 0.2253 0.3275
Schistosoma mansoni tyrosine kinase 0.0048 0.1126 0.1703
Trichomonas vaginalis tubulin beta chain, putative 0.0103 0.2852 1
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0017 0.0138 0.0201
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.004 0.0847 0.1575
Toxoplasma gondii beta-tubulin, putative 0.0084 0.2253 0.7794
Schistosoma mansoni tubulin subunit beta 0.0033 0.0656 0.0993
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0017 0.0149 0.0218
Trypanosoma brucei beta tubulin 0.0084 0.2253 0.2145
Echinococcus multilocularis Tubulin beta 2C chain 0.0084 0.2253 0.3296
Mycobacterium ulcerans methionine aminopeptidase 0.0046 0.1042 0.3916
Loa Loa (eye worm) hypothetical protein 0.004 0.0847 0.1211
Loa Loa (eye worm) TK/ABL protein kinase 0.0231 0.6836 1
Schistosoma mansoni protein kinase 0.0017 0.0138 0.0208
Loa Loa (eye worm) BEN-1 protein 0.0084 0.2253 0.3275
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0017 0.0138 0.0201
Leishmania major beta tubulin 0.0084 0.2253 0.2228
Trypanosoma cruzi zeta tubulin, putative 0.0331 1 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0084 0.2253 0.3296
Trypanosoma brucei epsilon tubulin 0.0068 0.1748 0.1633
Echinococcus granulosus calcium dependent protein kinase 0.0016 0.0112 0.0163
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0057 0.1404 0.1376
Entamoeba histolytica tubulin family protein 0.0084 0.2253 0.7794
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0009
Schistosoma mansoni cell adhesion molecule 0.0013 0.0022 0.0033
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0057 0.1404 0.1284
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.1404 0.1376
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0048 0.1126 0.1647
Echinococcus granulosus Tubulin alpha 1 chain 0.0103 0.2852 0.4172
Entamoeba histolytica protein kinase, putative 0.0034 0.0677 0.1988
Trypanosoma cruzi alpha tubulin, putative 0.0103 0.2852 0.2829
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0033 0.0656 0.1909
Echinococcus multilocularis Tubulin beta 2C chain 0.0084 0.2253 0.3296
Echinococcus multilocularis tubulin subunit beta 0.0084 0.2253 0.3296
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0014 0.0057 0.0051
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.1126 0.1647
Trypanosoma brucei alpha tubulin 0.0103 0.2852 0.2752
Echinococcus multilocularis Tubulin alpha 1 chain 0.0103 0.2852 0.4172
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0017 0.0138 0.0201
Plasmodium falciparum tubulin delta chain, putative 0.0033 0.0656 0.1909
Brugia malayi MAP kinase sur-1 0.0057 0.1404 0.2684
Trichomonas vaginalis tubulin beta chain, putative 0.0103 0.2852 1
Loa Loa (eye worm) alpha-tubulin 0.0103 0.2852 0.4153
Echinococcus multilocularis tubulin alpha 1C chain 0.0103 0.2852 0.4172
Brugia malayi hypothetical protein 0.0174 0.5075 1
Loa Loa (eye worm) tubulin beta-2A chain 0.0084 0.2253 0.3275
Plasmodium falciparum methionine aminopeptidase 1b, putative 0.0046 0.1042 0.3332
Plasmodium vivax tubulin alpha chain, putative 0.0103 0.2852 1
Loa Loa (eye worm) alpha-tubulin isotype 2 0.007 0.1805 0.2616
Giardia lamblia Alpha-tubulin 0.0103 0.2852 1
Echinococcus granulosus single minded 2 0.0038 0.0815 0.1192
Plasmodium vivax tubulin beta chain, putative 0.0084 0.2253 0.7794
Loa Loa (eye worm) tubulin beta-4 chain 0.0084 0.2253 0.3275
Trypanosoma brucei beta tubulin 0.0084 0.2253 0.2145
Trypanosoma brucei alpha tubulin, putative 0.0035 0.0701 0.0571
Echinococcus granulosus roundabout 2 0.0016 0.0102 0.0149
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.1126 0.1647
Echinococcus multilocularis NCK adaptor protein 0.0014 0.0057 0.0083
Trichomonas vaginalis CAMK family protein kinase 0.0017 0.0138 0.0374
Loa Loa (eye worm) tubulin alpha chain 0.0103 0.2852 0.4153
Schistosoma mansoni aldehyde dehydrogenase 0.0065 0.1642 0.2485
Loa Loa (eye worm) tubulin beta-1 chain 0.0084 0.2253 0.3275
Echinococcus multilocularis growth factor receptor bound protein 2 0.0014 0.0057 0.0083
Loa Loa (eye worm) hypothetical protein 0.0174 0.5075 0.7415
Schistosoma mansoni tubulin subunit gamma 0.0097 0.2653 0.4014
Echinococcus granulosus Tubulin beta 2C chain 0.0084 0.2253 0.3296
Echinococcus granulosus Tubulin alpha 1 chain 0.0103 0.2852 0.4172
Trichomonas vaginalis tubulin gamma chain, putative 0.0097 0.2653 0.9295
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0847 0.0818
Echinococcus multilocularis mitogen activated protein kinase 3 0.0057 0.1404 0.2054
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0048 0.1126 0.1647
Brugia malayi bZIP transcription factor family protein 0.009 0.2421 0.4712
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0048 0.1126 0.1647
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0046 0.1042 0.1525
Schistosoma mansoni serine/threonine protein kinase 0.0057 0.1404 0.2124
Trichomonas vaginalis tubulin beta chain, putative 0.0084 0.2253 0.7877
Brugia malayi Tyrosine-protein kinase abl-1 0.0101 0.2791 0.5447
Echinococcus granulosus lamin dm0 0.0029 0.0512 0.0749
Echinococcus granulosus Aryl hydrocarbon receptor nuclear 0.0014 0.0032 0.0047
Trichomonas vaginalis tubulin gamma chain, putative 0.0068 0.1748 0.6085
Trypanosoma cruzi epsilon tubulin, putative 0.0068 0.1748 0.1721
Leishmania major beta tubulin 0.0084 0.2253 0.2228
Plasmodium vivax methionine aminopeptidase 1a, putative 0.0046 0.1042 0.3332
Trichomonas vaginalis tubulin beta chain, putative 0.0103 0.2852 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0048 0.1126 0.1647
Echinococcus multilocularis Tubulin beta 2C chain 0.0084 0.2253 0.3296
Trypanosoma brucei tubulin gamma chain 0.0097 0.2653 0.2551
Loa Loa (eye worm) tubulin gamma chain 0.0097 0.2653 0.3861
Echinococcus multilocularis hypothetical protein 0.0103 0.2852 0.4172
Echinococcus multilocularis roundabout 2 0.0016 0.0102 0.0149
Trichomonas vaginalis tubulin epsilon chain, putative 0.0084 0.2253 0.7877
Echinococcus granulosus tubulin alpha 3 chain 0.0103 0.2852 0.4172
Loa Loa (eye worm) hypothetical protein 0.0013 0.0028 0.0009
Loa Loa (eye worm) hypothetical protein 0.0029 0.0512 0.0719
Loa Loa (eye worm) hypothetical protein 0.0017 0.0138 0.017
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0065 0.1642 0.1615
Leishmania major protein kinase, putative 0.0014 0.0059 0.0027
Echinococcus granulosus aryl hydrocarbon receptor 0.0014 0.0032 0.0047
Leishmania major beta tubulin 0.0084 0.2253 0.2228
Leishmania major beta tubulin 0.0084 0.2253 0.2228
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0485 0.0679
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0057 0.1404 0.2028
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0656 0.2213
Loa Loa (eye worm) TK protein kinase 0.0034 0.0677 0.0962
Mycobacterium ulcerans methionine aminopeptidase MapB 0.0046 0.1042 0.3916
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0014 0.0057 0.0086
Entamoeba histolytica tubulin alpha chain, putative 0.0103 0.2852 1
Loa Loa (eye worm) tubulin alpha-2 chain 0.0103 0.2852 0.4153
Trypanosoma brucei epsilon tubulin 0.0068 0.1748 0.1633
Echinococcus multilocularis calcium dependent protein kinase 0.0016 0.0112 0.0163
Echinococcus multilocularis tubulin alpha chain 0.0103 0.2852 0.4172
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0093 0.0104
Trichomonas vaginalis tubulin, putative 0.0062 0.1561 0.5422
Schistosoma mansoni protein kinase 0.0017 0.0138 0.0208
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0084 0.2253 0.3296
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0017 0.0138 0.0161
Echinococcus granulosus tyrosine protein kinase HCK 0.0034 0.0677 0.0991
Leishmania major protein kinase, putative 0.0014 0.0059 0.0027
Leishmania major alpha tubulin 0.0103 0.2852 0.2829
Echinococcus granulosus geminin 0.0181 0.5284 0.773
Brugia malayi Cam kinase protein 1 0.0017 0.0138 0.0161
Leishmania major alpha tubulin 0.0103 0.2852 0.2829
Echinococcus multilocularis tyrosine protein kinase Blk 0.0041 0.0904 0.1323
Brugia malayi Tubulin alpha chain 0.0103 0.2852 0.557
Loa Loa (eye worm) methionine aminopeptidase type I 0.0046 0.1042 0.1497
Schistosoma mansoni tubulin subunit beta 0.0084 0.2253 0.3409
Trypanosoma brucei beta tubulin 0.0084 0.2253 0.2145
Echinococcus granulosus tubulin alpha 3 chain 0.0103 0.2852 0.4172
Brugia malayi Immunoglobulin I-set domain containing protein 0.0164 0.4737 0.9326
Plasmodium falciparum alpha tubulin 2 0.0103 0.2852 1
Brugia malayi tubulin alpha chain - mouse 0.0103 0.2852 0.557
Echinococcus granulosus growth factor receptor bound protein 2 0.0014 0.0057 0.0083
Trypanosoma cruzi tubulin delta chain 0.0033 0.0656 0.0626
Onchocerca volvulus 0.0029 0.0512 0.1098
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0057 0.1404 0.4665
Loa Loa (eye worm) tubulin alpha 2 0.007 0.1805 0.2616
Schistosoma mansoni tubulin subunit beta 0.0084 0.2253 0.3409
Schistosoma mansoni aryl hydrocarbon receptor 0.0052 0.1238 0.1873
Leishmania major beta tubulin 0.0084 0.2253 0.2228
Echinococcus granulosus beta tubulin 0.0084 0.2253 0.3296
Loa Loa (eye worm) hypothetical protein 0.0131 0.3712 0.5415
Echinococcus granulosus tyrosine protein kinase Src42A 0.0038 0.0812 0.1188
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0041 0.0904 0.1323
Leishmania major alpha tubulin 0.0103 0.2852 0.2829
Leishmania major beta tubulin 0.0084 0.2253 0.2228
Loa Loa (eye worm) hypothetical protein 0.0069 0.176 0.2551
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0065 0.1642 0.2403
Brugia malayi intermediate filament protein 0.0029 0.0512 0.0907
Plasmodium falciparum tubulin beta chain 0.0084 0.2253 0.7794
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.1642 1
Onchocerca volvulus Huntingtin homolog 0.0131 0.3712 0.8419
Echinococcus granulosus NCK adaptor protein 0.0014 0.0057 0.0083
Echinococcus multilocularis tyrosine protein kinase HCK 0.0034 0.0677 0.0991
Echinococcus granulosus tyrosine protein kinase Blk 0.0041 0.0904 0.1323
Trichomonas vaginalis tubulin gamma chain, putative 0.0033 0.0656 0.2213
Echinococcus multilocularis Aryl hydrocarbon receptor nuclear 0.0014 0.0032 0.0047
Leishmania major beta tubulin 0.0084 0.2253 0.2228
Leishmania major gamma-tubulin 0.0097 0.2653 0.2629
Echinococcus multilocularis beta tubulin 0.0084 0.2253 0.3296
Trichomonas vaginalis tubulin, putative 0.0035 0.0701 0.2371
Loa Loa (eye worm) tubulin alpha chain 0.0103 0.2852 0.4153
Mycobacterium ulcerans putative regulatory protein 0.0038 0.0815 0.1607
Leishmania major alpha tubulin 0.0103 0.2852 0.2829
Echinococcus granulosus tyrosine protein kinase Src64B 0.0048 0.1126 0.1647
Schistosoma mansoni tubulin subunit beta 0.0084 0.2253 0.3409
Giardia lamblia Beta tubulin 0.0084 0.2253 0.7273
Trypanosoma cruzi STE group serine/threonine-protein kinase, putative 0.0014 0.0059 0.0027
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.004 0.0847 0.124
Echinococcus granulosus tubulin alpha 1C chain 0.0103 0.2852 0.4172
Echinococcus granulosus tubulin alpha 1C chain 0.0103 0.2852 0.4172
Brugia malayi Tubulin beta chain 0.0035 0.0701 0.1283
Leishmania major beta tubulin 0.0084 0.2253 0.2228
Toxoplasma gondii aldehyde dehydrogenase 0.0065 0.1642 0.5543
Trichomonas vaginalis tubulin epsilon chain, putative 0.0033 0.0656 0.2213
Brugia malayi tubulin alpha-2 chain 0.0103 0.2852 0.557
Onchocerca volvulus 0.0147 0.4231 0.9607
Trichomonas vaginalis tubulin beta chain, putative 0.0035 0.0701 0.2371
Toxoplasma gondii beta tubulin 0.0084 0.2253 0.7794
Giardia lamblia Beta tubulin 0.0084 0.2253 0.7273
Schistosoma mansoni tubulin subunit beta 0.0084 0.2253 0.3409
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0014 0.0045 0.0065
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0046 0.1042 0.1013
Brugia malayi Tubulin gamma chain 0.0097 0.2653 0.5174
Echinococcus granulosus Tubulin beta 2C chain 0.0084 0.2253 0.3296
Schistosoma mansoni methionyl aminopeptidase 1 (M24 family) 0.0046 0.1042 0.1577
Trypanosoma cruzi tubulin delta chain 0.0033 0.0656 0.0626
Plasmodium falciparum tubulin epsilon chain, putative 0.0068 0.1748 0.5933
Loa Loa (eye worm) hypothetical protein 0.0014 0.0045 0.0033
Leishmania major beta tubulin 0.0084 0.2253 0.2228
Toxoplasma gondii methionine aminopeptidase 0.0046 0.1042 0.3332
Echinococcus granulosus tubulin alpha chain 0.0103 0.2852 0.4172
Echinococcus multilocularis tubulin alpha chain 0.0103 0.2852 0.4172
Trypanosoma brucei alpha tubulin 0.0103 0.2852 0.2752
Trichomonas vaginalis tubulin beta chain, putative 0.0103 0.2852 1
Schistosoma mansoni tubulin subunit beta 0.0084 0.2253 0.3409
Schistosoma mansoni nck2/grb4 0.0014 0.0057 0.0086
Trypanosoma brucei methionine aminopeptidase, type I, putative 0.0046 0.1042 0.0917
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0017 0.0149 0.0218
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0059 0.0027
Leishmania major beta tubulin 0.0084 0.2253 0.2228
Brugia malayi hypothetical protein 0.0131 0.3712 0.7284
Trichomonas vaginalis tubulin gamma chain, putative 0.0084 0.2253 0.7877
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0057 0.1404 0.1376
Echinococcus granulosus tubulin subunit TubB 0.0103 0.2852 0.4172
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0014 0.0057 0.0051
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0057 0.1404 0.1376
Echinococcus multilocularis transfer RNA-Lys 0.0038 0.0815 0.1192
Giardia lamblia Gamma tubulin 0.0097 0.2653 0.9094
Schistosoma mansoni lamin 0.0029 0.0512 0.0775
Echinococcus granulosus c src tyrosine kinase 0.0017 0.0149 0.0218
Trichomonas vaginalis tubulin epsilon chain, putative 0.0103 0.2852 1
Toxoplasma gondii methionine aminopeptidase, type i, putative 0.0046 0.1042 0.3332
Echinococcus granulosus tubulin beta 4A class IVa 0.0084 0.2253 0.3296
Schistosoma mansoni alpha tubulin 0.0103 0.2852 0.4315
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.004 0.0847 0.1282
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0013 0.0022 0.0032
Mycobacterium ulcerans aldehyde dehydrogenase 0.0065 0.1642 1
Giardia lamblia Kinase, CMGC MAPK 0.0057 0.1404 0.3406
Echinococcus multilocularis jun protein 0.009 0.2421 0.3542
Echinococcus granulosus tubulin delta chain 0.0033 0.0656 0.096
Echinococcus multilocularis lamin 0.0029 0.0512 0.0749
Trichomonas vaginalis tubulin alpha chain, putative 0.0035 0.0701 0.2371
Plasmodium falciparum tubulin gamma chain 0.0097 0.2653 0.9267
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.004 0.0847 0.2614
Brugia malayi Cell division protein ftsZ 0.0033 0.0656 0.1194
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0048 0.1126 0.1647
Leishmania major alpha tubulin 0.0103 0.2852 0.2829
Trypanosoma brucei metallo- peptidase, Clan MG, Family M24 0.0046 0.1042 0.0917
Schistosoma mansoni tubulin subunit alpha 0.0103 0.2852 0.4315
Leishmania major alpha tubulin 0.0103 0.2852 0.2829
Onchocerca volvulus 0.0038 0.0815 0.179
Leishmania major beta tubulin 0.0084 0.2253 0.2228
Schistosoma mansoni tyrosine kinase 0.0048 0.1126 0.1703
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0048 0.1126 0.1647
Mycobacterium tuberculosis Methionine aminopeptidase MapA (map) (peptidase M) (MetAP) 0.0046 0.1042 0.3916
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0017 0.0138 0.0201
Echinococcus granulosus tubulin epsilon chain 0.0068 0.1748 0.2557
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0017 0.0138 0.0201
Brugia malayi Tubulin alpha-2 chain 0.0103 0.2852 0.557
Echinococcus granulosus jun protein 0.009 0.2421 0.3542
Plasmodium vivax tubulin alpha chain, putative 0.0103 0.2852 1
Echinococcus granulosus Tubulin beta 2C chain 0.0084 0.2253 0.3296
Echinococcus multilocularis beta tubulin 0.0084 0.2253 0.3296
Trypanosoma brucei methionine aminopeptidase, putative 0.0046 0.1042 0.0917
Brugia malayi Tubulin alpha-2 chain 0.0103 0.2852 0.557
Echinococcus multilocularis tyrosine protein kinase Srms 0.0041 0.0904 0.1323
Echinococcus granulosus tubulin beta 1 chain 0.0084 0.2253 0.3296
Mycobacterium leprae PROBABLE METHIONINE AMINOPEPTIDASE MAPA (MAP) (PEPTIDASE M) (MetAP) 0.0046 0.1042 1
Echinococcus multilocularis lamin dm0 0.0029 0.0512 0.0749
Trypanosoma brucei tubulin delta chain 0.0033 0.0656 0.0526
Trypanosoma brucei protein kinase, putative 0.0057 0.1404 0.1284
Trichomonas vaginalis tubulin beta chain, putative 0.0103 0.2852 1
Echinococcus multilocularis tubulin epsilon chain 0.0068 0.1748 0.2557
Echinococcus multilocularis peroxisome assembly protein 26 0.0103 0.2852 0.4172
Echinococcus granulosus methionyl aminopeptidase 1 M24 family 0.0046 0.1042 0.1525
Echinococcus multilocularis tubulin alpha 3 chain 0.0103 0.2852 0.4172
Leishmania major epsilon tubulin, putative 0.0068 0.1748 0.1721
Leishmania major beta tubulin 0.0084 0.2253 0.2228
Echinococcus granulosus Basic leucine zipper bZIP transcription factor 0.009 0.2421 0.3542
Loa Loa (eye worm) hypothetical protein 0.0087 0.2342 0.3405
Trichomonas vaginalis tubulin epsilon chain, putative 0.0103 0.2852 1
Schistosoma mansoni tyrosine kinase 0.0017 0.0149 0.0225
Echinococcus multilocularis tubulin gamma 1 chain 0.0097 0.2653 0.3881
Schistosoma mansoni alpha tubulin 0.0103 0.2852 0.4315
Echinococcus multilocularis methionyl aminopeptidase 1 (M24 family) 0.0046 0.1042 0.1525
Schistosoma mansoni tubulin subunit alpha 0.0103 0.2852 0.4315
Echinococcus granulosus Tubulin beta 2C chain 0.0084 0.2253 0.3296
Onchocerca volvulus 0.0035 0.0701 0.1529
Wolbachia endosymbiont of Brugia malayi methionine aminopeptidase 0.0046 0.1042 1
Schistosoma mansoni single-minded 0.0052 0.1238 0.1873
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0512 0.0719
Loa Loa (eye worm) tubulin beta chain 0.0033 0.0656 0.0931
Loa Loa (eye worm) hypothetical protein 0.0103 0.2852 0.4153
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0017 0.0138 0.0201
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0017 0.0138 0.0201
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0041 0.0904 0.1323
Trypanosoma cruzi zeta tubulin, putative 0.0331 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.1404 0.4865
Echinococcus multilocularis aryl hydrocarbon receptor 0.0014 0.0032 0.0047
Loa Loa (eye worm) hypothetical protein 0.0014 0.0032 0.0015
Echinococcus multilocularis musashi 0.0029 0.0512 0.0749
Trypanosoma brucei epsilon tubulin 0.0068 0.1748 0.1633
Trichomonas vaginalis tubulin, putative 0.0084 0.2253 0.7877
Mycobacterium tuberculosis Methionine aminopeptidase MapB (map) (peptidase M) 0.0046 0.1042 0.3916
Echinococcus multilocularis tubulin alpha 3 chain 0.0103 0.2852 0.4172
Toxoplasma gondii beta-1 tubulin, putative 0.0084 0.2253 0.7794
Echinococcus granulosus Tubulin beta 2C chain 0.0084 0.2253 0.3296
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0093 0.0071
Leishmania major alpha tubulin 0.0103 0.2852 0.2829
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.1404 0.4865
Echinococcus multilocularis Tubulin alpha 1 chain 0.0103 0.2852 0.4172
Echinococcus multilocularis tubulin alpha chain 0.0103 0.2852 0.4172
Schistosoma mansoni tubulin subunit delta 0.0033 0.0656 0.0993
Trypanosoma brucei alpha tubulin 0.0103 0.2852 0.2752
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.004 0.0847 0.124
Leishmania major alpha tubulin 0.0103 0.2852 0.2829
Trypanosoma brucei alpha tubulin 0.0103 0.2852 0.2752
Trichomonas vaginalis tubulin, putative 0.0035 0.0701 0.2371
Trichomonas vaginalis tubulin beta chain, putative 0.0103 0.2852 1
Schistosoma mansoni alpha tubulin 0.0103 0.2852 0.4315
Entamoeba histolytica tubulin gamma chain 0.0097 0.2653 0.9267
Echinococcus multilocularis c src tyrosine kinase 0.0017 0.0149 0.0218
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0847 0.2891
Echinococcus granulosus tyrosine protein kinase Src42A 0.0048 0.1126 0.1647
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0017 0.0138 0.017
Trichomonas vaginalis conserved hypothetical protein 0.0033 0.0656 0.2213
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0065 0.1642 1
Schistosoma mansoni hypothetical protein 0.0181 0.5284 0.7995
Trichomonas vaginalis tubulin epsilon chain, putative 0.0084 0.2253 0.7877
Schistosoma mansoni serine/threonine protein kinase 0.0017 0.0138 0.0208
Trichomonas vaginalis CMGC family protein kinase 0.0057 0.1404 0.4865
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.004 0.0847 0.2891
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.004 0.0847 0.072
Loa Loa (eye worm) hypoxia-induced factor 1 0.0161 0.4652 0.6794
Echinococcus multilocularis tyrosine protein kinase Abl 0.0101 0.2791 0.4082
Trypanosoma cruzi metallo- peptidase, Clan MG, Family M24 0.0046 0.1042 0.1013
Echinococcus multilocularis tubulin alpha chain 0.0103 0.2852 0.4172
Brugia malayi Cytochrome P450 family protein 0.0028 0.0485 0.0853
Loa Loa (eye worm) hypothetical protein 0.0028 0.0495 0.0695
Echinococcus multilocularis ubiquitin specific protease 41 0.004 0.0847 0.124
Brugia malayi hypothetical protein 0.007 0.1817 0.3508
Trypanosoma brucei beta tubulin 0.0068 0.1748 0.1633
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0069 0.176 0.6128
Brugia malayi hypoxia-induced factor 1 0.0161 0.4652 0.9156
Echinococcus granulosus tubulin alpha chain 0.0103 0.2852 0.4172
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0014 0.0059 0.0027
Schistosoma mansoni tubulin subunit alpha 0.0033 0.0656 0.0993
Brugia malayi alpha-tubulin 0.0103 0.2852 0.557
Echinococcus granulosus tubulin alpha chain 0.0103 0.2852 0.4172
Toxoplasma gondii methionine aminopeptidase 0.0046 0.1042 0.3332
Trichomonas vaginalis tubulin alpha chain, putative 0.0068 0.1748 0.6085
Loa Loa (eye worm) BEN-1 protein 0.0084 0.2253 0.3275
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.004 0.0847 0.124
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0103 0.2852 1
Echinococcus multilocularis tubulin alpha 0.0068 0.1748 0.2557
Echinococcus granulosus tyrosine protein kinase Fyn 0.0048 0.1126 0.1647
Plasmodium vivax tubulin epsilon chain, putative 0.0068 0.1748 0.5933
Loa Loa (eye worm) hypothetical protein 0.0016 0.0102 0.0117
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0068 0.1748 0.5933
Echinococcus multilocularis Tubulin beta 2C chain 0.0084 0.2253 0.3296
Echinococcus granulosus mitogen activated protein kinase 3 0.0057 0.1404 0.2054
Giardia lamblia Alpha-tubulin 0.0103 0.2852 1
Echinococcus granulosus intermediate filament protein 0.0029 0.0512 0.0749
Trichomonas vaginalis tubulin alpha chain, putative 0.0084 0.2253 0.7877
Echinococcus granulosus mitogen activated protein kinase 0.0057 0.1404 0.2054
Schistosoma mansoni intermediate filament proteins 0.0029 0.0512 0.0775
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0014 0.0045 0.0065
Trypanosoma cruzi tubulin gamma chain 0.0097 0.2653 0.2629
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0035 0.0701 0.2371
Loa Loa (eye worm) tubulin alpha 2 0.007 0.1805 0.2616
Loa Loa (eye worm) SRC-1 0.0048 0.1126 0.162
Brugia malayi Tubulin beta-1 chain 0.0084 0.2253 0.4377
Schistosoma mansoni protein kinase 0.0017 0.0138 0.0208
Echinococcus granulosus tyrosine kinase 0.0041 0.0904 0.1323
Echinococcus granulosus twitchin 0.0013 0.0026 0.0039
Trypanosoma brucei zeta tubulin, putative 0.0331 1 1
Plasmodium vivax delta tubulin, putative 0.0033 0.0656 0.1909
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0164 0.4737 0.6919
Echinococcus multilocularis tubulin alpha chain 0.0103 0.2852 0.4172
Schistosoma mansoni adapter molecule crk 0.0014 0.0057 0.0086
Trypanosoma cruzi epsilon tubulin, putative 0.0068 0.1748 0.1721
Schistosoma mansoni tubulin subunit epsilon 0.0068 0.1748 0.2645
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0057 0.1404 0.1376
Toxoplasma gondii alpha-tubulin I, putative 0.0103 0.2852 1
Leishmania major beta tubulin 0.0084 0.2253 0.2228
Brugia malayi PAS domain containing protein 0.0052 0.1238 0.2354
Echinococcus granulosus tubulin alpha chain 0.0103 0.2852 0.4172
Schistosoma mansoni jun-related protein 0.0073 0.1895 0.2866

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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