Detailed information for compound 1655110

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 490.541 | Formula: C24H25F3N4O2S
  • H donors: 2 H acceptors: 2 LogP: 3.95 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@@H](Oc1cc(ccc1C(=O)N)c1cc(cnc1N)c1scc(c1)CN(C)C)/C=C\C(F)(F)F
  • InChi: 1S/C24H25F3N4O2S/c1-14(6-7-24(25,26)27)33-20-10-16(4-5-18(20)23(29)32)19-9-17(11-30-22(19)28)21-8-15(13-34-21)12-31(2)3/h4-11,13-14H,12H2,1-3H3,(H2,28,30)(H2,29,32)/b7-6-/t14-/m1/s1
  • InChiKey: LLEOOSLUHRQCHZ-LMVHVUTASA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens LYN proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References
Homo sapiens protein kinase D2 Starlite/ChEMBL References
Homo sapiens MET proto-oncogene, receptor tyrosine kinase Starlite/ChEMBL References
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Starlite/ChEMBL References
Homo sapiens TTK protein kinase Starlite/ChEMBL References
Homo sapiens NIMA-related kinase 2 Starlite/ChEMBL References
Homo sapiens LCK proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References
Homo sapiens cyclin-dependent kinase 3 Starlite/ChEMBL References
Homo sapiens FYN proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References
Homo sapiens polo-like kinase 1 Starlite/ChEMBL References
Homo sapiens ABL proto-oncogene 1, non-receptor tyrosine kinase Starlite/ChEMBL References
Homo sapiens checkpoint kinase 2 Starlite/ChEMBL References
Homo sapiens aurora kinase A Starlite/ChEMBL References
Homo sapiens glycogen synthase kinase 3 beta Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Giardia lamblia Kinase, NEK Get druggable targets OG5_129446 All targets in OG5_129446
Plasmodium yoelii putative protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130080 All targets in OG5_130080
Schistosoma japonicum ko:K08850 aurora kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania major protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_129446 All targets in OG5_129446
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_128695 All targets in OG5_128695
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Plasmodium yoelii cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Candida albicans likely protein kinase similar to S. cerevisiae KIN3 (YAR018C) Get druggable targets OG5_129446 All targets in OG5_129446
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus tyrosine protein kinase ABL1 Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis dual specificity serine:threonine tyrosine Get druggable targets OG5_129339 All targets in OG5_129339
Plasmodium falciparum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense polo-like protein kinase,protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans kinase involved in DNA repair Get druggable targets OG5_128695 All targets in OG5_128695
Brugia malayi C1-like domain containing protein Get druggable targets OG5_130080 All targets in OG5_130080
Candida albicans protein kinase Get druggable targets OG5_128695 All targets in OG5_128695
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Neospora caninum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii NIMA-related protein kinase NIMA1 Get druggable targets OG5_129446 All targets in OG5_129446
Cryptosporidium parvum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K02090 cyclin-dependent kinase 5, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma congolense cdc2-related kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi Tyrosine-protein kinase abl-1 Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans second truncated form of RIM11 Serine/threonine protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi Phorbol esters/diacylglycerol binding domain Get druggable targets OG5_130080 All targets in OG5_130080
Candida albicans protein kinase Get druggable targets OG5_128695 All targets in OG5_128695
Schistosoma mansoni protein kinase C mu Get druggable targets OG5_130080 All targets in OG5_130080
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I Get druggable targets OG5_128695 All targets in OG5_128695
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma brucei protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130080 All targets in OG5_130080
Neospora caninum MGC81305 protein, related Get druggable targets OG5_129446 All targets in OG5_129446
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_128695 All targets in OG5_128695
Giardia lamblia Kinase, TTK Get druggable targets OG5_129339 All targets in OG5_129339
Brugia malayi serine/threonine kinase 12 Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax protein kinase Crk2 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Entamoeba histolytica serine/threonine protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) AUR protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania mexicana cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania major cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Toxoplasma gondii aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania infantum cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans likely protein kinase similar to S. cerevisiae KIN3 (YAR018C) Get druggable targets OG5_129446 All targets in OG5_129446
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K02087 cyclin-dependent kinase 1, putative Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus serine:threonine protein kinase 12 B Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126888 All targets in OG5_126888
Candida albicans protein threonine/tyrosine kinase Get druggable targets OG5_129339 All targets in OG5_129339
Schistosoma japonicum expressed protein Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum expressed protein Get druggable targets OG5_131234 All targets in OG5_131234
Trypanosoma brucei polo-like protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Tyrosine-protein kinase transforming protein Abl, putative Get druggable targets OG5_131234 All targets in OG5_131234
Neospora caninum hypothetical protein Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Serine/threonine-protein kinase 12, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium knowlesi NIMA related kinase 1, putative Get druggable targets OG5_129446 All targets in OG5_129446
Entamoeba histolytica protein kinase , putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica serine/threonine- protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC GSK Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum expressed protein Get druggable targets OG5_130080 All targets in OG5_130080
Plasmodium falciparum serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma brucei gambiense protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Candida albicans protein serine/threonine kinase Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis cell division protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Serine\/threonine kinase homolog Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Cryptosporidium parvum NEK2 protein, putative Get druggable targets OG5_129446 All targets in OG5_129446
Giardia lamblia Kinase, PLK Get druggable targets OG5_127396 All targets in OG5_127396
Leishmania braziliensis protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_129339 All targets in OG5_129339
Schistosoma japonicum hypothetical protein Get druggable targets OG5_130080 All targets in OG5_130080
Brugia malayi serine/threonine-protein kinase plk-2 Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma cruzi aurora B kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Brugia malayi serine/threonine protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Theileria parva cell division control protein 2 related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Onchocerca volvulus Get druggable targets OG5_130080 All targets in OG5_130080
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus granulosus cyclin dependent kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) PLK/PLK1 protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium vivax serine/threonine protein kinase 6, putative Get druggable targets OG5_127024 All targets in OG5_127024
Plasmodium berghei serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni dual specificity serine/threonine tyrosine kinase Get druggable targets OG5_129339 All targets in OG5_129339
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Theileria parva glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum ko:K06070 protein kinase D, putative Get druggable targets OG5_130080 All targets in OG5_130080
Trypanosoma cruzi cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Serine/threonine protein kinase required for induction of IME2 by Ime1p Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Babesia bovis protein kinase domain containing protein Get druggable targets OG5_129446 All targets in OG5_129446
Echinococcus multilocularis serine:threonine protein kinase PLK1 Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma brucei cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Plasmodium berghei cdc2-related kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium hominis protein kinase (EC 2.7.1.-) p46XlEg22 Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus protein kinase shaggy Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum Tyrosine-protein kinase transforming protein Abl, putative Get druggable targets OG5_131234 All targets in OG5_131234
Trypanosoma cruzi polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Loa Loa (eye worm) TK/ABL protein kinase Get druggable targets OG5_131234 All targets in OG5_131234
Entamoeba histolytica serine/threonine- protein kinase 6 , putative Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi serine/threonine protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Kinase, NEK Get druggable targets OG5_129446 All targets in OG5_129446
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma congolense aurora B kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense cdc2-related kinase 3, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, CMGC CDK Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania braziliensis protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Schistosoma japonicum ko:K06641 serine/threonine-protein kinase Chk2, putative Get druggable targets OG5_128695 All targets in OG5_128695
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130080 All targets in OG5_130080
Trichomonas vaginalis STE family protein kinase Get druggable targets OG5_129446 All targets in OG5_129446
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Cryptosporidium hominis NEK2 protein Get druggable targets OG5_129446 All targets in OG5_129446
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trypanosoma cruzi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania mexicana protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Neospora caninum CMGC kinase, CDK family TgPK2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Onchocerca volvulus Get druggable targets OG5_130080 All targets in OG5_130080
Plasmodium yoelii Protein kinase domain, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K08822 glycogen synthase kinase 3 alpha, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania infantum protein kinase, putative,polo-like protein kinase, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium berghei glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus serine:threonine protein kinase Chk2 Get druggable targets OG5_128695 All targets in OG5_128695
Cryptosporidium parvum Cdc2-like CDK2/CDC28 like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CMGC/GSK protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Plasmodium berghei NIMA related kinase 1, putative Get druggable targets OG5_129446 All targets in OG5_129446
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126712 All targets in OG5_126712
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase ABL1, putative Get druggable targets OG5_131234 All targets in OG5_131234
Brugia malayi intracellular kinase Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_129339 All targets in OG5_129339
Schistosoma mansoni serine/threonine protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Babesia bovis cell division control protein 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_130080 All targets in OG5_130080
Trypanosoma brucei cdc2-related kinase 1 Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania donovani Aurora I-related kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma congolense protein kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus aurora kinase A Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus calcium:calmodulin dependent protein kinase I Get druggable targets OG5_128695 All targets in OG5_128695
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus glycogen synthase kinase 3 beta Get druggable targets OG5_126888 All targets in OG5_126888
Schistosoma japonicum hypothetical protein Get druggable targets OG5_130080 All targets in OG5_130080
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) Get druggable targets OG5_126888 All targets in OG5_126888
Brugia malayi serine/threonine-protein kinase 6 Get druggable targets OG5_127024 All targets in OG5_127024
Cryptosporidium hominis cdc2-like protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Echinococcus multilocularis tyrosine protein kinase ABL1 Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum ko:K06070 protein kinase D, putative Get druggable targets OG5_130080 All targets in OG5_130080
Onchocerca volvulus Dual specificity protein kinase TTK homolog Get druggable targets OG5_129339 All targets in OG5_129339
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania braziliensis protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania mexicana protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_128695 All targets in OG5_128695
Echinococcus multilocularis tyrosine protein kinase Abl Get druggable targets OG5_131234 All targets in OG5_131234
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_127396 All targets in OG5_127396
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania mexicana protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania major cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Trypanosoma brucei gambiense cell division protein kinase 2 homolog 1,cdc2- like protein kinase, putative Get druggable targets OG5_126712 All targets in OG5_126712
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Plasmodium yoelii NIMA-related protein kinase Get druggable targets OG5_129446 All targets in OG5_129446
Leishmania major protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Entamoeba histolytica cell division protein kinase 2, putative Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium knowlesi glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania braziliensis cell division related protein kinase 2,cdc2-related kinase Get druggable targets OG5_126712 All targets in OG5_126712
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis serine:threonine protein kinase Chk2 Get druggable targets OG5_128695 All targets in OG5_128695
Candida albicans kinase involved in DNA repair Get druggable targets OG5_128695 All targets in OG5_128695
Schistosoma mansoni protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Theileria parva NIMA-related protein kinase, putative Get druggable targets OG5_129446 All targets in OG5_129446
Trichomonas vaginalis CAMK family protein kinase Get druggable targets OG5_129339 All targets in OG5_129339
Plasmodium knowlesi Cell division control protein 2 homolog Get druggable targets OG5_126712 All targets in OG5_126712
Cryptosporidium parvum hypothetical protein Get druggable targets OG5_126888 All targets in OG5_126888
Echinococcus multilocularis cyclin dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Onchocerca volvulus Get druggable targets OG5_130080 All targets in OG5_130080
Loa Loa (eye worm) CAMK/PKD protein kinase Get druggable targets OG5_130080 All targets in OG5_130080
Trypanosoma brucei gambiense cell division related protein kinase 2, putative,CDC2-related protein kinase Get druggable targets OG5_126712 All targets in OG5_126712
Leishmania infantum glycogen synthase kinase 3 Get druggable targets OG5_126888 All targets in OG5_126888
Trypanosoma brucei gambiense protein kinase, putative,glycogen synthase kinase, putative Get druggable targets OG5_126888 All targets in OG5_126888
Trichomonas vaginalis CMGC family protein kinase Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum Serine/threonine-protein kinase PLK1, putative Get druggable targets OG5_127396 All targets in OG5_127396
Plasmodium falciparum NIMA related kinase 1 Get druggable targets OG5_129446 All targets in OG5_129446
Plasmodium falciparum protein kinase 5 Get druggable targets OG5_126712 All targets in OG5_126712
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Giardia lamblia Aurora kinase Get druggable targets OG5_127024 All targets in OG5_127024
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus dual specificity serine:threonine tyrosine Get druggable targets OG5_129339 All targets in OG5_129339
Schistosoma japonicum ko:K05501 TetR/AcrR family transcriptional regulator, putative Get druggable targets OG5_129339 All targets in OG5_129339
Loa Loa (eye worm) TTK protein kinase Get druggable targets OG5_129339 All targets in OG5_129339
Trichomonas vaginalis AGC family protein kinase Get druggable targets OG5_127024 All targets in OG5_127024
Trypanosoma cruzi cdc2-related kinase 3 Get druggable targets OG5_126712 All targets in OG5_126712
Candida albicans Protein kinase that can substitute for S. cerevisiae CDC28 (YBR160W) main cell cycle cyclin-dependent kinase Get druggable targets OG5_126712 All targets in OG5_126712
Giardia lamblia Kinase, NEK Get druggable targets OG5_129446 All targets in OG5_129446
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Candida albicans likely protein kinase similar to S. cerevisiae IPL1 (YPL209C) Aurora protein kinase involved in regulating kinetochore-microtubu Get druggable targets OG5_127024 All targets in OG5_127024
Leishmania donovani cell division protein kinase 2 Get druggable targets OG5_126712 All targets in OG5_126712
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative Get druggable targets OG5_129446 All targets in OG5_129446
Onchocerca volvulus Get druggable targets OG5_126888 All targets in OG5_126888
Leishmania donovani glycogen synthase kinase 3, putative Get druggable targets OG5_126888 All targets in OG5_126888
Loa Loa (eye worm) CAMK/PKD protein kinase Get druggable targets OG5_130080 All targets in OG5_130080
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania infantum protein kinase, putative Get druggable targets OG5_127024 All targets in OG5_127024
Schistosoma japonicum ko:K06631 polo-like kinase 1, putative Get druggable targets OG5_127396 All targets in OG5_127396
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 cyclin-dependent kinase 3 305 aa 303 aa 32.0 %
Giardia lamblia Kinase, NEK NIMA-related kinase 2 388 aa 312 aa 25.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0049 0.0938 0.0819
Trichomonas vaginalis AGC family protein kinase 0.0071 0.1813 0.2214
Plasmodium falciparum serine/threonine protein kinase, putative 0.0071 0.1813 0.1391
Schistosoma mansoni tyrosine kinase 0.0029 0.0129 0.0024
Schistosoma mansoni protein kinase 0.0071 0.1813 0.1889
Schistosoma mansoni tyrosine kinase 0.0121 0.3763 0.4049
Toxoplasma gondii NIMA-related protein kinase NIMA1 0.0128 0.4046 0.6284
Plasmodium vivax FAD-dependent monooxygenase, putative 0.0171 0.5742 1
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0049 0.0938 0.082
Plasmodium vivax NIMA-related protein kinase (Pfnek-1), putative 0.0128 0.4046 0.6284
Giardia lamblia Kinase, PLK 0.0118 0.3641 0.8588
Schistosoma mansoni nck2/grb4 0.0043 0.0689 0.0644
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.0034 0.0328 0.0201
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0121 0.3763 0.3681
Schistosoma mansoni hypothetical protein 0.0171 0.5742 0.6241
Echinococcus multilocularis ubiquinone biosynthesis monooxygenase COQ6 0.0171 0.5742 0.5687
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0118 0.3641 0.3558
Loa Loa (eye worm) hypothetical protein 0.0098 0.2865 0.2772
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0049 0.0938 0.082
Schistosoma mansoni monoxygenase 0.0171 0.5742 0.6241
Echinococcus granulosus tyrosine protein kinase Btk29A 0.005 0.0972 0.0854
Echinococcus granulosus glycogen synthase kinase 3 beta 0.0061 0.1413 0.1301
Schistosoma mansoni tyrosine kinase 0.005 0.0972 0.0958
Schistosoma mansoni protein kinase C mu 0.0114 0.3502 0.376
Loa Loa (eye worm) AUR protein kinase 0.0071 0.1813 0.1706
Schistosoma mansoni serine/threonine protein kinase 0.0071 0.1813 0.1889
Loa Loa (eye worm) hypothetical protein 0.0102 0.3038 0.2948
Mycobacterium tuberculosis Possible oxidoreductase 0.0171 0.5742 0.5
Onchocerca volvulus 0.011 0.3347 0.9164
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.0114 0.3502 0.6816
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.3641 0.8588
Chlamydia trachomatis monooxygenase 0.0171 0.5742 0.5
Trichomonas vaginalis CAMK family protein kinase 0.009 0.2566 0.4838
Loa Loa (eye worm) hypothetical protein 0.011 0.3347 0.3261
Echinococcus multilocularis protein MICAL 3 0.0171 0.5742 0.5687
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.005 0.0972 0.0958
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0071 0.1813 0.4979
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.1413 0.0819
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0049 0.0938 0.0819
Echinococcus granulosus aurora kinase A 0.0071 0.1813 0.1706
Brugia malayi cell division control protein 2 homolog 0.0055 0.1178 0.212
Echinococcus granulosus tyrosine protein kinase Blk 0.0099 0.292 0.2827
Onchocerca volvulus 0.0098 0.2865 0.7791
Entamoeba histolytica protein kinase , putative 0.0071 0.1813 0.4979
Loa Loa (eye worm) TTK protein kinase 0.009 0.2566 0.2469
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0114 0.3502 0.3417
Echinococcus granulosus tyrosine protein kinase Lyn 0.0125 0.3917 0.3838
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0055 0.1178 0.1063
Leishmania major protein kinase, putative 0.0071 0.1813 0.1391
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0055 0.1178 0.1063
Brugia malayi protein-tyrosine kinase 0.0099 0.292 0.5639
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0092 0.2636 0.254
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0043 0.0689 0.0567
Entamoeba histolytica protein kinase, putative 0.0078 0.2055 0.5644
Trypanosoma cruzi polo-like protein kinase, putative 0.0118 0.3641 0.5397
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0071 0.1813 0.4979
Mycobacterium tuberculosis Probable oxidoreductase 0.0171 0.5742 0.5
Loa Loa (eye worm) hypothetical protein 0.011 0.3347 0.3261
Brugia malayi Variant SH3 domain containing protein 0.0034 0.0328 0.0402
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0938 0.0921
Entamoeba histolytica cell division protein kinase 2, putative 0.0055 0.1178 0.3236
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0121 0.3763 0.3681
Schistosoma mansoni tyrosine kinase 0.0029 0.0129 0.0024
Toxoplasma gondii FAD binding domain-containing protein 0.0171 0.5742 1
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0055 0.1178 0.1063
Entamoeba histolytica protein kinase domain containing protein 0.0061 0.1413 0.388
Echinococcus multilocularis tyrosine protein kinase HCK 0.0078 0.2055 0.1951
Brugia malayi Tyrosine-protein kinase abl-1 0.0145 0.4746 0.933
Entamoeba histolytica serine/threonine protein kinase, putative 0.0118 0.3641 1
Echinococcus multilocularis tyrosine protein kinase Abl 0.0145 0.4746 0.4678
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0121 0.3763 0.3681
Onchocerca volvulus Dual specificity protein kinase TTK homolog 0.009 0.2566 0.6938
Echinococcus multilocularis glycogen synthase kinase 3 beta 0.0061 0.1413 0.1301
Echinococcus granulosus tyrosine protein kinase HCK 0.0078 0.2055 0.1951
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0071 0.1813 0.4979
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0071 0.1813 0.1391
Mycobacterium ulcerans hypothetical protein 0.0171 0.5742 0.5
Echinococcus granulosus NCK adaptor protein 0.0043 0.0689 0.0567
Entamoeba histolytica protein kinase domain containing protein 0.0071 0.1813 0.4979
Echinococcus granulosus ubiquinone biosynthesis monooxygenase COQ6 0.0171 0.5742 0.5687
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0121 0.3763 0.3681
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0118 0.3641 0.3558
Trypanosoma cruzi polo-like protein kinase, putative 0.0118 0.3641 0.5397
Schistosoma mansoni adapter molecule crk 0.0043 0.0689 0.0644
Echinococcus granulosus cyclin dependent kinase 1 0.0055 0.1178 0.1063
Brugia malayi serine/threonine-protein kinase 6 0.0071 0.1813 0.3403
Mycobacterium ulcerans oxidoreductase 0.0171 0.5742 0.5
Echinococcus multilocularis cyclin dependent kinase 0.0055 0.1178 0.1063
Echinococcus multilocularis tyrosine protein kinase Blk 0.0099 0.292 0.2827
Echinococcus multilocularis N chimaerin 0.0034 0.0328 0.0201
Echinococcus multilocularis NCK adaptor protein 0.0043 0.0689 0.0567
Brugia malayi Protein kinase domain containing protein 0.009 0.2566 0.4924
Plasmodium vivax glycogen synthase kinase 3, putative 0.0061 0.1413 0.0514
Echinococcus granulosus tyrosine protein kinase Fyn 0.0121 0.3763 0.3681
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0121 0.3763 0.3681
Loa Loa (eye worm) RhoGAP domain-containing protein 0.0034 0.0328 0.0201
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.1413 0.0819
Loa Loa (eye worm) hypothetical protein 0.0043 0.0689 0.0567
Brugia malayi SRC-1 0.0121 0.3763 0.7343
Giardia lamblia Aurora kinase 0.0071 0.1813 0.2214
Echinococcus granulosus tyrosine protein kinase Src64B 0.0121 0.3763 0.3681
Entamoeba histolytica protein kinase, putative 0.0061 0.1413 0.388
Echinococcus granulosus cyclin dependent kinase 5 0.0055 0.1178 0.1063
Leishmania major glycogen synthase kinase, putative;with=GeneDB:LinJ18_V3.0270 0.0061 0.1413 0.0514
Leishmania major hypothetical protein, conserved 0.0171 0.5742 1
Brugia malayi serine/threonine protein kinase 6 0.0071 0.1813 0.3403
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0121 0.3763 0.3681
Loa Loa (eye worm) hypothetical protein 0.0171 0.5742 0.5687
Echinococcus granulosus N chimaerin 0.0034 0.0328 0.0201
Echinococcus multilocularis dual specificity serine:threonine tyrosine 0.009 0.2566 0.2469
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.1178 0.1186
Wolbachia endosymbiont of Brugia malayi 2-polyprenyl-6-methoxyphenol 4-hydroxylase 0.0171 0.5742 0.5
Brugia malayi Variant SH3 domain containing protein 0.0043 0.0689 0.1131
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0034 0.0328 0.0244
Entamoeba histolytica protein kinase domain containing protein 0.0061 0.1413 0.388
Trichomonas vaginalis AGC family protein kinase 0.0071 0.1813 0.2214
Giardia lamblia Kinase, NEK 0.0128 0.4046 1
Onchocerca volvulus 0.0061 0.1413 0.3656
Toxoplasma gondii aurora kinase 0.0071 0.1813 0.1391
Schistosoma mansoni vav2 0.0034 0.0328 0.0244
Entamoeba histolytica protein kinase, putative 0.0049 0.0938 0.2577
Echinococcus granulosus c src tyrosine kinase 0.005 0.0972 0.0854
Echinococcus granulosus protein MICAL 3 0.0171 0.5742 0.5687
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.3641 0.8588
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0278 1 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0118 0.3641 1
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0121 0.3763 0.3681
Schistosoma mansoni tyrosine kinase 0.0121 0.3763 0.4049
Giardia lamblia Kinase, TTK 0.009 0.2566 0.4838
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.3641 0.8588
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0055 0.1178 0.1063
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0121 0.3763 0.3681
Brugia malayi Protein kinase domain containing protein 0.0055 0.1178 0.212
Echinococcus multilocularis c src tyrosine kinase 0.005 0.0972 0.0854
Giardia lamblia Kinase, NEK 0.0128 0.4046 1
Echinococcus multilocularis protein kinase shaggy 0.0061 0.1413 0.1301
Mycobacterium tuberculosis Possible oxidoreductase 0.0171 0.5742 0.5
Trichomonas vaginalis STE family protein kinase 0.0128 0.4046 1
Mycobacterium ulcerans FAD-dependent oxidoreductase 0.0171 0.5742 0.5
Schistosoma mansoni growth factor receptor-bound protein 0.0043 0.0689 0.0644
Loa Loa (eye worm) AUR protein kinase 0.0071 0.1813 0.1706
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0102 0.302 0.2929
Entamoeba histolytica protein kinase, putative 0.0071 0.1813 0.4979
Echinococcus multilocularis cyclin dependent kinase 1 0.0055 0.1178 0.1063
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.0034 0.0328 0.0201
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.005 0.0972 0.0854
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.3641 0.8588
Echinococcus granulosus cyclin dependent kinase 0.0055 0.1178 0.1063
Trypanosoma brucei kynurenine 3-monooxygenase, putative 0.0171 0.5742 1
Plasmodium falciparum NIMA related kinase 1 0.0128 0.4046 0.6284
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0118 0.3641 0.5397
Mycobacterium tuberculosis Possible oxidoreductase 0.0171 0.5742 0.5
Trichomonas vaginalis CAMK family protein kinase 0.009 0.2566 0.4838
Echinococcus granulosus tyrosine protein kinase Fyn 0.0121 0.3763 0.3681
Echinococcus multilocularis cyclin dependent kinase 5 0.0055 0.1178 0.1063
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0121 0.3763 0.3681
Schistosoma mansoni dual specificity serine/threonine tyrosine kinase 0.009 0.2566 0.2723
Mycobacterium ulcerans hypothetical protein 0.0171 0.5742 0.5
Brugia malayi intracellular kinase 0.0061 0.1413 0.2595
Echinococcus multilocularis growth factor receptor bound protein 2 0.0043 0.0689 0.0567
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.3641 0.8588
Echinococcus multilocularis cyclin dependent kinase 1 0.0055 0.1178 0.1063
Echinococcus granulosus dual specificity serine:threonine tyrosine 0.009 0.2566 0.2469
Trypanosoma cruzi glycogen synthase kinase 3, putative 0.0061 0.1413 0.0514
Trypanosoma brucei aurora B kinase 0.0071 0.1813 0.1391
Loa Loa (eye worm) TK protein kinase 0.0078 0.2055 0.1951
Trichomonas vaginalis AGC family protein kinase 0.0071 0.1813 0.2214
Onchocerca volvulus 0.011 0.3347 0.9164
Trypanosoma cruzi Monooxygenase, putative 0.0171 0.5742 1
Mycobacterium ulcerans membrane-associated oxidoreductase 0.0171 0.5742 0.5
Leishmania major hypothetical protein, conserved 0.0171 0.5742 1
Brugia malayi Variant SH3 domain containing protein 0.0043 0.0689 0.1131
Plasmodium falciparum glycogen synthase kinase 3 0.0061 0.1413 0.0514
Brugia malayi RhoGAP domain containing protein 0.0034 0.0328 0.0402
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0029 0.0129 0.0354
Plasmodium vivax hypothetical protein, conserved 0.0171 0.5742 1
Schistosoma mansoni kinase 0.0061 0.1418 0.1452
Schistosoma mansoni tyrosine kinase 0.005 0.0972 0.0958
Echinococcus granulosus tyrosine kinase 0.0099 0.292 0.2827
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0061 0.1413 0.1301
Echinococcus multilocularis tyrosine protein kinase Srms 0.0099 0.292 0.2827
Trichomonas vaginalis AGC family protein kinase 0.0128 0.4046 1
Plasmodium falciparum FAD-dependent monooxygenase, putative 0.0171 0.5742 1
Brugia malayi Tyrosine-protein kinase abl-1 0.0154 0.5078 1
Echinococcus granulosus growth factor receptor bound protein 2 0.0043 0.0689 0.0567
Mycobacterium tuberculosis Probable oxidoreductase 0.0171 0.5742 0.5
Entamoeba histolytica protein kinase, putative 0.0049 0.0938 0.2577
Echinococcus multilocularis aurora kinase A 0.0071 0.1813 0.1706
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0071 0.1813 0.1706
Mycobacterium ulcerans FAD-linked oxidoreductase 0.0171 0.5742 0.5
Giardia lamblia Kinase, CMGC GSK 0.0061 0.1413 0.0819
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0043 0.0689 0.0644
Schistosoma mansoni glycogen synthase kinase 3-related (gsk3) (cmgc group III) 0.0061 0.1413 0.1446
Schistosoma mansoni serine/threonine protein kinase 0.0118 0.3641 0.3914
Toxoplasma gondii cell-cycle-associated protein kinase GSK, putative 0.0061 0.1413 0.0514
Mycobacterium ulcerans oxidoreductase GMC-type 0.0171 0.5742 0.5
Echinococcus granulosus tyrosine protein kinase Fyn 0.0121 0.3763 0.3681
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.3641 0.8588
Loa Loa (eye worm) hypothetical protein 0.0052 0.1024 0.0907
Trypanosoma brucei Monooxygenase, putative 0.0171 0.5742 1
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.0034 0.0328 0.0244
Toxoplasma gondii FAD binding domain-containing protein 0.0171 0.5742 1
Brugia malayi serine/threonine-protein kinase plk-2 0.0118 0.3641 0.7097
Brugia malayi C1-like domain containing protein 0.0114 0.3502 0.6816
Loa Loa (eye worm) TK/ABL protein kinase 0.0278 1 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0121 0.3763 0.3681
Brugia malayi Sex muscle abnormal protein 5 0.0043 0.0689 0.1131
Trichomonas vaginalis CAMK family protein kinase 0.0118 0.3641 0.8588
Trichomonas vaginalis CAMK family protein kinase 0.006 0.1358 0.0629
Loa Loa (eye worm) AUR protein kinase 0.0071 0.1813 0.1706
Trypanosoma cruzi hypothetical protein, conserved 0.0171 0.5742 1
Giardia lamblia Kinase, NEK 0.0128 0.4046 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0118 0.3641 0.3558
Entamoeba histolytica cell division protein kinase 2, putative 0.0055 0.1178 0.3236
Brugia malayi serine/threonine kinase 12 0.0071 0.1813 0.3403
Echinococcus granulosus protein kinase shaggy 0.0061 0.1413 0.1301
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0099 0.292 0.2827
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0071 0.1813 0.1706
Giardia lamblia Kinase, CMGC GSK 0.0061 0.1413 0.0819
Loa Loa (eye worm) hypothetical protein 0.0098 0.2865 0.2772
Trichomonas vaginalis CAMK family protein kinase 0.006 0.1358 0.0629
Echinococcus granulosus tyrosine protein kinase Src42A 0.0092 0.2636 0.254
Mycobacterium leprae possibleputative FAD-linked oxidoreductase 0.0171 0.5742 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0055 0.1178 0.1186
Trichomonas vaginalis AGC family protein kinase 0.0071 0.1813 0.2214
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0121 0.3763 0.3681
Trypanosoma cruzi aurora B kinase, putative 0.0071 0.1813 0.1391
Trypanosoma brucei polo-like protein kinase 0.0118 0.3641 0.5397
Schistosoma mansoni growth factor receptor-bound protein 0.0043 0.0689 0.0644
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0099 0.292 0.2827
Loa Loa (eye worm) CMGC/GSK protein kinase 0.0061 0.1413 0.1301
Loa Loa (eye worm) SRC-1 0.0121 0.3763 0.3681
Mycobacterium ulcerans hypothetical protein 0.0171 0.5742 0.5
Mycobacterium ulcerans oxidoreductase 0.0171 0.5742 0.5
Echinococcus granulosus tyrosine protein kinase Src42A 0.0121 0.3763 0.3681
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0043 0.0689 0.0567
Entamoeba histolytica protein kinase, putative 0.0071 0.1813 0.4979
Loa Loa (eye worm) TK protein kinase 0.0099 0.292 0.2827
Schistosoma mansoni tyrosine kinase 0.0256 0.9135 1
Trypanosoma brucei protein kinase, putative 0.0061 0.1413 0.0514

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) = 1.82 uM Growth inhibition of human U2OS cells after 92 hrs by CellTiter-Blue assay ChEMBL. 22404346
IC50 (binding) = 0.022 uM Inhibition of Nek2 using 5-FAM-KKLNRTLSVA-COOH as substrate after 1 hr by caliper method ChEMBL. 22404346
IC50 (binding) = 0.07 uM Inhibition of GSK3beta incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
IC50 (binding) = 0.11 uM Inhibition of LCK incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
IC50 (binding) = 0.33 uM Inhibition of PKD2 incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
IC50 (binding) = 0.75 uM Inhibition of FYN incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
IC50 (binding) = 0.8 uM Inhibition of Nek2-mediated C-Nap1 phosphorylation in human U2OS cells after 3 hrs by immunofluorescence microscopy ChEMBL. 22404346
IC50 (binding) = 0.84 uM Inhibition of SRC incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
IC50 (binding) = 1.11 uM Inhibition of ABL at 1 uM ChEMBL. 22404346
IC50 (binding) = 1.17 uM Inhibition of MET incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
IC50 (binding) = 1.36 uM Inhibition of LYN incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
IC50 (binding) = 2 uM Inhibition of CHK2 incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
IC50 (binding) = 4.57 uM Inhibition of CDK2 by caliper method ChEMBL. 22404346
IC50 (binding) = 4.94 uM Inhibition of Aurora A kinase by caliper method ChEMBL. 22404346
IC50 (binding) = 5.82 uM Inhibition of Plk1 using 5-FAMRRRAGALMDASFEEQ- CONH2 as substrate after 75 mins by caliper method ChEMBL. 22404346
IC50 (binding) = 8.47 uM Inhibition of MPS1 by caliper method ChEMBL. 22404346
Inhibition (binding) Reversible inhibition of Nek2 using 5-FAM-KKLNRTLSVA-COOH as substrate after 1 hr by caliper method ChEMBL. 22404346
Inhibition (binding) Inhibition of Nek2-mediated C-Nap1 phosphorylation in human U2OS cells after 3 hrs by immunofluorescence microscopy ChEMBL. 22404346
Inhibition (binding) = 0 % Inhibition of AKT2 at 1 uM incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
Inhibition (binding) = 0 % Inhibition of INSR at 1 uM incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
Inhibition (binding) = 0 % Inhibition of p38alpha at 1 uM incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
Inhibition (binding) = 2 % Inhibition of Erk1 at 1 uM incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
Inhibition (binding) = 3 % Inhibition of AKT1 at 1 uM incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
Inhibition (binding) = 6 % Inhibition of MAPKAPK2 at 1 uM incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
Inhibition (binding) = 7 % Inhibition of PRAK at 1 uM incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
Inhibition (binding) = 11 % Inhibition of CHK1 at 1 uM incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
Inhibition (binding) = 11 % Inhibition of Erk2 at 1 uM incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
Inhibition (binding) = 12 % Inhibition of PKCzeta at 1 uM incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
Inhibition (binding) = 19 % Inhibition of AURA at 1 uM incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
Inhibition (binding) = 25 % Inhibition of MSK1 at 1 uM incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
Inhibition (binding) = 29 % Inhibition of RSK1 at 1 uM incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
Inhibition (binding) = 32 % Inhibition of CHK2 at 1 uM incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
Inhibition (binding) = 43 % Inhibition of LYN at 1 uM incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
Inhibition (binding) = 46 % Inhibition of ABL at 1 uM incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
Inhibition (binding) = 46 % Inhibition of MET at 1 uM incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
Inhibition (binding) = 51 % Inhibition of SRC at 1 uM incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
Inhibition (binding) = 57 % Inhibition of FYN at 1 uM incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
Inhibition (binding) = 77 % Inhibition of PKD2 at 1 uM incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
Inhibition (binding) = 89 % Inhibition of LCK at 1 uM incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
Inhibition (binding) = 93 % Inhibition of GSK3beta at 1 uM incubated for 30 mins prior to substrate addition study done at apparent ATP Km for enzyme ChEMBL. 22404346
Ratio IC50 (binding) = 40 Ratio of IC50 for Nek2-mediated C-Nap1 phosphorylation in human U2OS cells to IC50 for Nek2 by caliper method ChEMBL. 22404346

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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