Detailed information for compound 1656948

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 352.433 | Formula: C19H24N6O
  • H donors: 2 H acceptors: 3 LogP: 2.08 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1C)c1nn(c2c1c(N)ncn2)CC1CCNCC1
  • InChi: 1S/C19H24N6O/c1-12-9-14(3-4-15(12)26-2)17-16-18(20)22-11-23-19(16)25(24-17)10-13-5-7-21-8-6-13/h3-4,9,11,13,21H,5-8,10H2,1-2H3,(H2,20,22,23)
  • InChiKey: MQULVMDBNSSIMR-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase Starlite/ChEMBL References
Homo sapiens ABL proto-oncogene 1, non-receptor tyrosine kinase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) TK/ABL protein kinase Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum expressed protein Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi Tyrosine-protein kinase abl-1 Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Tyrosine-protein kinase transforming protein Abl, putative Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus granulosus tyrosine protein kinase ABL1 Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase ABL1, putative Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase ABL1 Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Abl Get druggable targets OG5_131234 All targets in OG5_131234
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131234 All targets in OG5_131234
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum Tyrosine-protein kinase transforming protein Abl, putative Get druggable targets OG5_131234 All targets in OG5_131234
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum expressed protein Get druggable targets OG5_131234 All targets in OG5_131234
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.0703 0.0795
Echinococcus granulosus Tubulin beta 2C chain 0.0139 0.0678 0.1614
Loa Loa (eye worm) hypothetical protein 0.0186 0.0928 0.5613
Leishmania major hypothetical protein, conserved 0.0051 0.0214 0.0666
Trypanosoma cruzi alpha tubulin, putative 0.0258 0.1307 0.4783
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0186 0.0928 0.128
Leishmania major importin beta-1 subunit, putative 0.0025 0.0075 0.0139
Leishmania major epsilon tubulin, putative 0.0139 0.0678 0.2412
Loa Loa (eye worm) TK protein kinase 0.0046 0.0186 0.1124
Echinococcus multilocularis tubulin epsilon chain 0.0139 0.0678 0.0766
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0012 0.0071
Leishmania major alpha tubulin 0.0258 0.1307 0.4783
Loa Loa (eye worm) hypothetical protein 0.0053 0.0225 0.1363
Loa Loa (eye worm) tubulin alpha chain 0.0258 0.1307 0.7903
Echinococcus granulosus peroxisome assembly protein 26 0.0258 0.1307 0.3112
Echinococcus granulosus tubulin alpha chain 0.0258 0.1307 0.3112
Echinococcus granulosus TRP transient receptor potential channel 0.0038 0.0145 0.0346
Echinococcus granulosus importin subunit beta 1 0.003 0.0105 0.025
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0046 0.0186 0.0443
Schistosoma mansoni growth factor receptor-bound protein 0.0016 0.003 0.0072
Brugia malayi Tubulin beta chain 0.0079 0.036 0.0496
Echinococcus multilocularis tubulin alpha chain 0.0258 0.1307 0.1478
Echinococcus granulosus GPCR family 2 0.0016 0.0027 0.0065
Loa Loa (eye worm) hypothetical protein 0.0186 0.0928 0.5613
Trypanosoma brucei beta tubulin 0.0139 0.0678 0.251
Leishmania major beta tubulin 0.0139 0.0678 0.2412
Brugia malayi Tubulin alpha-2 chain 0.0258 0.1307 0.1802
Echinococcus granulosus growth factor receptor bound protein 2 0.0016 0.003 0.0072
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0054 0.0228 0.0258
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0073 0.0258
Schistosoma mansoni adapter molecule crk 0.0016 0.003 0.0072
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0075 0.0547
Echinococcus multilocularis Tubulin beta 2C chain 0.0139 0.0678 0.0766
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0054 0.0228 0.0258
Trypanosoma brucei tubulin delta chain 0.006 0.0263 0.0967
Schistosoma mansoni hypothetical protein 0.0023 0.0066 0.0157
Brugia malayi RNA binding protein 0.0065 0.029 0.04
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0038 0.0001
Schistosoma mansoni hypothetical protein 0.0806 0.42 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.0174 0.1052
Trichomonas vaginalis tubulin epsilon chain, putative 0.0139 0.0678 0.5175
Loa Loa (eye worm) tubulin alpha-3 chain 0.018 0.0892 0.5394
Echinococcus granulosus tyrosine protein kinase ABL1 0.026 0.1315 0.313
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.029 0.04
Plasmodium vivax importin-beta 2, putative 0.003 0.0105 0.0242
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0012 0.0071
Leishmania major alpha tubulin 0.0258 0.1307 0.4783
Brugia malayi Tyrosine-protein kinase abl-1 0.0114 0.0545 0.0751
Loa Loa (eye worm) tubulin alpha 2 0.0198 0.0989 0.5978
Loa Loa (eye worm) BEN-1 protein 0.0139 0.0678 0.4099
Loa Loa (eye worm) tyrosinase 1 0.0186 0.0928 0.5613
Echinococcus multilocularis Tubulin beta 2C chain 0.0139 0.0678 0.0766
Echinococcus multilocularis snurportin 1 0.0324 0.1654 0.187
Leishmania major alpha tubulin 0.0258 0.1307 0.4783
Trypanosoma cruzi beta tubulin, putative 0.0139 0.0678 0.2412
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.014 0.0158
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0000094675 0.0001
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.014 0.0333
Entamoeba histolytica tubulin alpha chain, putative 0.0258 0.1307 1
Schistosoma mansoni tubulin subunit beta 0.0139 0.0678 0.1614
Schistosoma mansoni hypothetical protein 0.0016 0.0027 0.0065
Entamoeba histolytica tubulin gamma chain 0.0139 0.0678 0.5187
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0038 0.0052
Schistosoma mansoni alpha tubulin 0.0258 0.1307 0.3112
Echinococcus granulosus tar DNA binding protein 0.0065 0.029 0.0692
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0073 0.0082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0703 0.1674
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0038 0.0145 0.0164
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0018 0.0037 0.0089
Loa Loa (eye worm) tubulin beta-2A chain 0.0139 0.0678 0.4099
Loa Loa (eye worm) tubulin beta chain 0.0139 0.0678 0.4099
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0105 0.0378
Brugia malayi tubulin alpha-2 chain 0.0258 0.1307 0.1802
Loa Loa (eye worm) RNA binding protein 0.0065 0.029 0.1756
Schistosoma mansoni tar DNA-binding protein 0.0065 0.029 0.0692
Entamoeba histolytica hypothetical protein 0.0024 0.0073 0.0555
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0014 0.0019 0.0045
Trypanosoma brucei alpha tubulin 0.0258 0.1307 0.485
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0000094675 0.0001
Leishmania major beta tubulin 0.0139 0.0678 0.2412
Schistosoma mansoni hypothetical protein 0.0042 0.0166 0.0394
Brugia malayi Transient-receptor-potential like protein 0.0038 0.0145 0.02
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0073 0.1462
Echinococcus granulosus tyrosine protein kinase Fyn 0.0054 0.0228 0.0543
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Plasmodium falciparum alpha tubulin 1 0.0258 0.1307 0.4777
Loa Loa (eye worm) tubulin alpha 2 0.0198 0.0989 0.5978
Plasmodium falciparum telomerase reverse transcriptase 0.052 0.2691 1
Leishmania major delta tubulin, putative 0.006 0.0263 0.0849
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0198 0.0989 0.7558
Echinococcus granulosus Niemann Pick C1 protein 0.0101 0.0479 0.114
Trichomonas vaginalis tubulin epsilon chain, putative 0.0139 0.0678 0.5175
Loa Loa (eye worm) hypothetical protein 0.0024 0.0073 0.0444
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0012 0.0071
Loa Loa (eye worm) SRC-1 0.0054 0.0228 0.1379
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0247
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0000094675 0.0001
Echinococcus multilocularis geminin 0.0164 0.0813 0.0919
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0018 0.0038 0.0129
Echinococcus granulosus tyrosine protein kinase Blk 0.0046 0.0186 0.0443
Echinococcus multilocularis Tubulin beta 2C chain 0.0139 0.0678 0.0766
Trypanosoma brucei alpha tubulin 0.0258 0.1307 0.485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Echinococcus multilocularis tubulin alpha 1C chain 0.0258 0.1307 0.1478
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0206 0.0284
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0054 0.0228 0.0258
Echinococcus multilocularis Tubulin alpha 1 chain 0.0258 0.1307 0.1478
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0000094675 0.0001
Schistosoma mansoni hypothetical protein 0.0164 0.0813 0.1935
Trichomonas vaginalis tubulin alpha chain, putative 0.0139 0.0678 0.5175
Echinococcus granulosus cpg binding protein 0.006 0.0261 0.062
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.014 0.0333
Brugia malayi CXXC zinc finger family protein 0.0057 0.0244 0.0336
Loa Loa (eye worm) hypothetical protein 0.0049 0.0206 0.1245
Trichomonas vaginalis tubulin alpha chain, putative 0.0079 0.036 0.2733
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0214 0.0655
Loa Loa (eye worm) hypothetical protein 0.0021 0.0055 0.0331
Giardia lamblia Epsilon tubulin 0.006 0.0263 0.0849
Schistosoma mansoni hypothetical protein 0.0016 0.0027 0.0065
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0012 0.0071
Echinococcus multilocularis dnaJ subfamily B 0.0806 0.42 0.4749
Loa Loa (eye worm) tubulin beta chain 0.006 0.0263 0.1591
Leishmania major alpha tubulin 0.0258 0.1307 0.4783
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0206 0.1245
Schistosoma mansoni tubulin subunit epsilon 0.0139 0.0678 0.1614
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0042 0.0142
Schistosoma mansoni tar DNA-binding protein 0.0065 0.029 0.0692
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0018 0.0037 0.0042
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0054 0.0228 0.0543
Loa Loa (eye worm) hypothetical protein 0.0016 0.003 0.0182
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Leishmania major beta tubulin 0.0139 0.0678 0.2412
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0023 0.0066 0.0074
Schistosoma mansoni cpg binding protein 0.006 0.0261 0.062
Loa Loa (eye worm) hypothetical protein 0.018 0.0892 0.5394
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0012 0.0071
Schistosoma mansoni alpha tubulin 0.0258 0.1307 0.3112
Onchocerca volvulus 0.001 0.0000094675 0.0000094675
Brugia malayi CHE-14 protein 0.0043 0.0174 0.024
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.0174 0.0197
Echinococcus granulosus tubulin alpha chain 0.0258 0.1307 0.3112
Leishmania major beta tubulin 0.0139 0.0678 0.2412
Echinococcus granulosus short transient receptor potential channel 6 0.0068 0.0301 0.0717
Schistosoma mansoni tyrosine kinase 0.0054 0.0228 0.0543
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0257 0.1302 0.1796
Loa Loa (eye worm) hypothetical protein 0.0102 0.0484 0.2925
Onchocerca volvulus 0.0024 0.0073 0.0073
Echinococcus granulosus tubulin subunit beta 0.0139 0.0678 0.1614
Onchocerca volvulus 0.0079 0.036 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Trichomonas vaginalis tubulin gamma chain, putative 0.0139 0.0678 0.5175
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0103 0.0487 0.1159
Echinococcus multilocularis tubulin alpha 1C chain 0.0258 0.1307 0.1478
Echinococcus granulosus Tubulin beta 2C chain 0.0139 0.0678 0.1614
Echinococcus granulosus Tubulin alpha 1 chain 0.0258 0.1307 0.3112
Loa Loa (eye worm) alpha-tubulin 0.0258 0.1307 0.7903
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0018 0.0038 0.0289
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0038 0.009
Brugia malayi Tubulin alpha chain 0.0258 0.1307 0.1802
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0038 0.0043
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0012 0.0071
Giardia lamblia Beta tubulin 0.0139 0.0678 0.2412
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0075 0.0547
Echinococcus granulosus tubulin alpha chain 0.0258 0.1307 0.3112
Trypanosoma brucei beta tubulin 0.0139 0.0678 0.251
Schistosoma mansoni transient receptor potential channel 0.0068 0.0301 0.0717
Loa Loa (eye worm) hypothetical protein 0.0043 0.0174 0.1052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Schistosoma mansoni tyrosinase precursor 0.0186 0.0928 0.221
Echinococcus multilocularis expressed conserved protein 0.0095 0.0446 0.0505
Trichomonas vaginalis tubulin, putative 0.006 0.0263 0.1993
Leishmania major beta tubulin 0.0139 0.0678 0.2412
Toxoplasma gondii beta-1 tubulin, putative 0.0139 0.0678 0.251
Echinococcus granulosus tubulin alpha 3 chain 0.0258 0.1307 0.3112
Echinococcus multilocularis tubulin delta chain 0.006 0.0263 0.0297
Plasmodium vivax tubulin epsilon chain, putative 0.0139 0.0678 0.2404
Plasmodium falciparum alpha tubulin 2 0.0258 0.1307 0.4777
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0075 0.0547
Toxoplasma gondii alpha-tubulin I, putative 0.0258 0.1307 0.485
Entamoeba histolytica Ran family GTPase 0.0022 0.0063 0.0478
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Schistosoma mansoni tubulin subunit alpha 0.0258 0.1307 0.3112
Echinococcus multilocularis beta tubulin 0.0139 0.0678 0.0766
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0063 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Echinococcus multilocularis transient receptor potential ion channel A 0.0099 0.0466 0.0527
Leishmania major beta tubulin 0.0139 0.0678 0.2412
Trypanosoma brucei PAB1-binding protein , putative 0.0051 0.0214 0.0786
Schistosoma mansoni tyrosine kinase 0.0251 0.1272 0.3027
Echinococcus multilocularis Tubulin alpha 1 chain 0.0258 0.1307 0.1478
Entamoeba histolytica hypothetical protein 0.0025 0.0075 0.057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Giardia lamblia Delta tubulin 0.006 0.0263 0.0849
Mycobacterium ulcerans hypothetical protein 0.0024 0.0073 0.1462
Leishmania major gamma-tubulin 0.0139 0.0678 0.2412
Trichomonas vaginalis tubulin epsilon chain, putative 0.006 0.0263 0.1993
Brugia malayi hypothetical protein 0.0033 0.0119 0.0164
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0023 0.0066 0.0157
Echinococcus multilocularis transient receptor potential gamma protein 0.0102 0.0484 0.0547
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0054 0.0228 0.0258
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0073 0.1462
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0144 0.0703 0.4251
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0186 0.0928 0.128
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0836 0.6384
Echinococcus multilocularis Niemann Pick C1 protein 0.0101 0.0479 0.0541
Schistosoma mansoni patched 1 0.0043 0.0174 0.0414
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0042 0.0014
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0073 0.0101
Onchocerca volvulus 0.001 0.0000094675 0.0000094675
Echinococcus granulosus tubulin gamma 1 chain 0.0139 0.0678 0.1614
Brugia malayi Variant SH3 domain containing protein 0.0016 0.003 0.0041
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0027 0.0065
Brugia malayi hypothetical protein 0.0051 0.0214 0.0296
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0042 0.0003
Trichomonas vaginalis tubulin beta chain, putative 0.0258 0.1307 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0247
Echinococcus granulosus Tubulin alpha 1 chain 0.0258 0.1307 0.3112
Echinococcus granulosus tyrosine protein kinase Fyn 0.0054 0.0228 0.0543
Trichomonas vaginalis tubulin beta chain, putative 0.0258 0.1307 1
Echinococcus granulosus tyrosine protein kinase HCK 0.0038 0.0143 0.034
Echinococcus multilocularis tubulin alpha 3 chain 0.0258 0.1307 0.1478
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0042 0.0317
Echinococcus granulosus Tubulin beta 2C chain 0.0139 0.0678 0.1614
Schistosoma mansoni tar DNA-binding protein 0.0065 0.029 0.0692
Echinococcus granulosus tyrosine protein kinase Src42A 0.0043 0.0174 0.0414
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0073 0.0101
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0036 0.005
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0836 0.6384
Leishmania major beta tubulin 0.0139 0.0678 0.2412
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0079 0.036 0.2733
Onchocerca volvulus 0.001 0.0000094675 0.0000094675
Plasmodium falciparum tubulin gamma chain 0.0139 0.0678 0.2404
Trichomonas vaginalis tubulin epsilon chain, putative 0.0258 0.1307 1
Loa Loa (eye worm) beta-tubulin 0.0139 0.0678 0.4099
Schistosoma mansoni tubulin subunit delta 0.006 0.0263 0.0626
Echinococcus granulosus NCK adaptor protein 0.0016 0.003 0.0072
Echinococcus multilocularis NCK adaptor protein 0.0016 0.003 0.0034
Leishmania major alpha tubulin 0.0258 0.1307 0.4783
Brugia malayi Importin beta-1 subunit 0.003 0.0105 0.0145
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0214 0.0666
Brugia malayi Hypothetical tyrosinase-like protein C02C2.1 in chromosome III 0.0186 0.0928 0.128
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0063 0.0071
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Brugia malayi Tubulin alpha-2 chain 0.0258 0.1307 0.1802
Leishmania major beta tubulin 0.0139 0.0678 0.2412
Trypanosoma brucei alpha tubulin 0.0258 0.1307 0.485
Toxoplasma gondii RNA-directed DNA polymerase 0.052 0.2691 1
Trichomonas vaginalis tubulin epsilon chain, putative 0.0258 0.1307 1
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0014 0.0019 0.0045
Echinococcus multilocularis tyrosine protein kinase HCK 0.0038 0.0143 0.0161
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.052 0.2691 1
Schistosoma mansoni ran 0.0022 0.0063 0.0149
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0046 0.0186 0.021
Echinococcus granulosus tubulin subunit TubB 0.0258 0.1307 0.3112
Echinococcus granulosus transient receptor potential ion channel A 0.0099 0.0466 0.1109
Schistosoma mansoni tubulin subunit beta 0.0139 0.0678 0.1614
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0073 0.0561
Loa Loa (eye worm) hypothetical protein 0.0258 0.1307 0.7903
Giardia lamblia Alpha-tubulin 0.0258 0.1307 0.4783
Trypanosoma brucei beta tubulin 0.0139 0.0678 0.251
Echinococcus granulosus tubulin alpha 0.0139 0.0678 0.1614
Echinococcus multilocularis tubulin alpha 3 chain 0.0258 0.1307 0.1478
Echinococcus granulosus tubulin alpha 1C chain 0.0258 0.1307 0.3112
Loa Loa (eye worm) TK protein kinase 0.0038 0.0143 0.0863
Echinococcus multilocularis Tubulin alpha 1 chain 0.0258 0.1307 0.1478
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0063 0.0221
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0703 0.1674
Leishmania major beta tubulin 0.0139 0.0678 0.2412
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0063 0.0093
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0324 0.1654 1
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0054 0.0228 0.0258
Brugia malayi ShTK domain containing protein 0.0186 0.0928 0.128
Echinococcus multilocularis hypothetical protein 0.0258 0.1307 0.1478
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0101 0.0479 0.3662
Echinococcus granulosus short transient receptor potential channel 6 0.0068 0.0301 0.0717
Schistosoma mansoni tyrosinase precursor 0.0186 0.0928 0.221
Trichomonas vaginalis tubulin beta chain, putative 0.0258 0.1307 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Leishmania major telomerase reverse transcriptase, putative 0.052 0.2691 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0073 0.0561
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0054 0.0228 0.0258
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0042 0.0057
Trichomonas vaginalis tubulin alpha chain, putative 0.0139 0.0678 0.5175
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Echinococcus multilocularis peroxisome assembly protein 26 0.0258 0.1307 0.1478
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.0139 0.0678 0.251
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0027 0.0166
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0063 0.0149
Echinococcus granulosus Tubulin alpha 1 chain 0.0258 0.1307 0.3112
Loa Loa (eye worm) tubulin beta-1 chain 0.0139 0.0678 0.4099
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0027 0.0038
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0063 0.0221
Leishmania major beta tubulin 0.0139 0.0678 0.2412
Toxoplasma gondii target of rapamycin (TOR), putative 0.0018 0.0038 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Echinococcus multilocularis tubulin alpha chain 0.0258 0.1307 0.1478
Echinococcus granulosus geminin 0.0164 0.0813 0.1935
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0042 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Leishmania major beta tubulin 0.0139 0.0678 0.2412
Entamoeba histolytica tubulin alpha-1 chain 0.0258 0.1307 1
Brugia malayi Cell division protein ftsZ 0.006 0.0263 0.0363
Trichomonas vaginalis helicase, putative 0.0013 0.0012 0.0071
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0075 0.0139
Leishmania major alpha tubulin 0.0258 0.1307 0.4783
Loa Loa (eye worm) hypothetical protein 0.0035 0.0127 0.0769
Loa Loa (eye worm) hypothetical protein 0.0034 0.0123 0.0746
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0247
Wolbachia endosymbiont of Brugia malayi cell division protein FtsZ 0.006 0.0263 1
Loa Loa (eye worm) tubulin alpha chain 0.0258 0.1307 0.7903
Echinococcus granulosus snurportin 1 0.0324 0.1654 0.3938
Loa Loa (eye worm) tubulin gamma chain 0.0139 0.0678 0.4099
Echinococcus granulosus tubulin beta 4A class IVa 0.0139 0.0678 0.1614
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0043 0.0174 0.0197
Leishmania major beta tubulin 0.0139 0.0678 0.2412
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0836 0.6384
Echinococcus multilocularis short transient receptor potential channel 6 0.0068 0.0301 0.0341
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0012 0.0071
Leishmania major beta tubulin 0.0139 0.0678 0.2412
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0042 0.0047
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0014 0.0019 0.0021
Trypanosoma brucei alpha tubulin 0.0258 0.1307 0.485
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.0258 0.1307 1
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0042 0.0294
Leishmania major alpha tubulin 0.0258 0.1307 0.4783
Schistosoma mansoni cpg binding protein 0.0057 0.0244 0.058
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0027 0.0065
Loa Loa (eye worm) hypothetical protein 0.003 0.0105 0.0634
Trypanosoma cruzi zeta tubulin, putative 0.006 0.0263 0.0849
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0073 0.0532
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0073 0.1659
Schistosoma mansoni hypothetical protein 0.0042 0.0166 0.0394
Entamoeba histolytica hypothetical protein 0.0037 0.014 0.107
Echinococcus multilocularis short transient receptor potential channel 6 0.0068 0.0301 0.0341
Loa Loa (eye worm) hypothetical protein 0.0024 0.0073 0.0444
Loa Loa (eye worm) hypothetical protein 0.0024 0.0073 0.0444
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0244 0.1473
Loa Loa (eye worm) histone methyltransferase 0.0018 0.0037 0.0225
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Echinococcus multilocularis tar DNA binding protein 0.0065 0.029 0.0328
Schistosoma mansoni ap endonuclease 0.0018 0.0042 0.0099
Trypanosoma cruzi tubulin delta chain 0.006 0.0263 0.0849
Loa Loa (eye worm) hypothetical protein 0.0101 0.0479 0.2895
Echinococcus multilocularis protein dispatched 1 0.005 0.0206 0.0233
Schistosoma mansoni tyrosine kinase 0.0018 0.0042 0.01
Trichomonas vaginalis tubulin gamma chain, putative 0.006 0.0263 0.1993
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0042 0.0294
Echinococcus multilocularis tubulin subunit beta 0.0139 0.0678 0.0766
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0073 0.1659
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0263 0.1993
Schistosoma mansoni ap endonuclease 0.0018 0.0042 0.0099
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0139 0.0678 0.0766
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0042 0.0262
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0000094675 0.0001
Schistosoma mansoni tubulin subunit beta 0.006 0.0263 0.0626
Leishmania major beta tubulin 0.0139 0.0678 0.2412
Giardia lamblia Beta tubulin 0.0139 0.0678 0.2412
Loa Loa (eye worm) TAR-binding protein 0.0065 0.029 0.1756
Loa Loa (eye worm) TK/ABL protein kinase 0.026 0.1315 0.7949
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0018 0.0038 0.0129
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0012 0.0071
Trypanosoma cruzi tubulin gamma chain 0.0139 0.0678 0.2412
Loa Loa (eye worm) hypothetical protein 0.0016 0.0027 0.0166
Echinococcus granulosus beta tubulin 0.0139 0.0678 0.1614
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0018 0.0042 0.01
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0144 0.0703 0.1674
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0174 0.1309
Entamoeba histolytica hypothetical protein 0.0037 0.014 0.107
Echinococcus granulosus dnaJ subfamily B 0.0806 0.42 1
Toxoplasma gondii LsmAD domain-containing protein 0.0051 0.0214 0.0786
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1302 0.9965
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0012 0.0071
Plasmodium vivax tubulin alpha chain, putative 0.0258 0.1307 0.4777
Echinococcus multilocularis tubulin alpha chain 0.0258 0.1307 0.1478
Echinococcus granulosus tubulin alpha 1C chain 0.0258 0.1307 0.3112
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0042 0.0003
Trichomonas vaginalis tubulin beta chain, putative 0.0079 0.036 0.2733
Schistosoma mansoni hypothetical protein 0.0034 0.0123 0.0294
Trypanosoma cruzi zeta tubulin, putative 0.006 0.0263 0.0849
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0027 0.0031
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0012 0.0071
Schistosoma mansoni nck2/grb4 0.0016 0.003 0.0072
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Loa Loa (eye worm) sex muscle abnormal protein 5 0.0016 0.003 0.0182
Echinococcus multilocularis Tubulin beta 2C chain 0.0139 0.0678 0.0766
Schistosoma mansoni transient receptor potential channel 4 0.0102 0.0484 0.1152
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0836 0.6384
Echinococcus multilocularis tubulin gamma 1 chain 0.0139 0.0678 0.0766
Trichomonas vaginalis tubulin, putative 0.0079 0.036 0.2733
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0073 0.0173
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0123 0.017
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0073 0.1462
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0257 0.1302 0.7875
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0000094675 0.0001
Schistosoma mansoni tubulin subunit alpha 0.006 0.0263 0.0626
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0144 0.0703 0.0795
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0038 0.009
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0038 0.009
Trypanosoma brucei tubulin gamma chain 0.0139 0.0678 0.251
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0073 0.01
Echinococcus multilocularis tyrosine protein kinase Abl 0.0114 0.0545 0.0616
Leishmania major alpha tubulin 0.0258 0.1307 0.4783
Trypanosoma brucei zeta tubulin 0.006 0.0263 0.0967
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0073 0.0101
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0018 0.0038 0.0289
Echinococcus multilocularis tubulin subunit TubB 0.0258 0.1307 0.1478
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0063 0.0086
Onchocerca volvulus 0.0186 0.0928 0.0928
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0012 0.0071
Echinococcus granulosus Niemann Pick C1 protein 0.0145 0.0708 0.1685
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.029 0.1756
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0073 0.0134
Schistosoma mansoni importin beta-1 0.003 0.0105 0.025
Brugia malayi Hypothetical tyrosinase-like protein F21C3.2 in chromosome I 0.0186 0.0928 0.128
Giardia lamblia Beta tubulin 0.0139 0.0678 0.2412
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0105 0.0378
Trichomonas vaginalis tubulin alpha-1 chain, putative 0.018 0.0892 0.6818
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.0703 0.1674
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Schistosoma mansoni tubulin subunit beta 0.0139 0.0678 0.1614
Schistosoma mansoni hypothetical protein 0.0164 0.0813 0.1935
Schistosoma mansoni tar DNA-binding protein 0.0065 0.029 0.0692
Loa Loa (eye worm) hypothetical protein 0.0038 0.0145 0.0878
Leishmania major beta tubulin 0.0139 0.0678 0.2412
Schistosoma mansoni tubulin subunit beta 0.0139 0.0678 0.1614
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0073 0.1462
Brugia malayi SRC-1 0.0054 0.0228 0.0314
Brugia malayi protein-tyrosine kinase 0.0046 0.0186 0.0256
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Echinococcus multilocularis tubulin alpha 0.0139 0.0678 0.0766
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0884 0.6752
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0054 0.0228 0.0258
Echinococcus multilocularis c src tyrosine kinase 0.0018 0.0042 0.0048
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0054 0.0228 0.0258
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0018 0.0042 0.0048
Schistosoma mansoni alpha tubulin 0.0258 0.1307 0.3112
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.0174 0.0414
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0018 0.0038 0.0129
Trypanosoma brucei zeta tubulin, putative 0.006 0.0263 0.0967
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0042 0.0251
Plasmodium vivax delta tubulin, putative 0.006 0.0263 0.0839
Onchocerca volvulus 0.0057 0.0244 0.0244
Echinococcus multilocularis growth factor receptor bound protein 2 0.0016 0.003 0.0034
Echinococcus multilocularis tubulin alpha chain 0.0258 0.1307 0.1478
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0038 0.0229
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1302 0.9965
Entamoeba histolytica hypothetical protein 0.0037 0.014 0.107
Trichomonas vaginalis tubulin beta chain, putative 0.0258 0.1307 1
Trypanosoma cruzi telomerase reverse transcriptase, putative 0.052 0.2691 1
Toxoplasma gondii beta tubulin 0.0139 0.0678 0.251
Schistosoma mansoni mixed-lineage leukemia protein mll 0.012 0.0579 0.1377
Onchocerca volvulus 0.0186 0.0928 0.0928
Trypanosoma brucei epsilon tubulin 0.0139 0.0678 0.251
Schistosoma mansoni cpg binding protein 0.006 0.0261 0.062
Loa Loa (eye worm) tubulin alpha-2 chain 0.0258 0.1307 0.7903
Loa Loa (eye worm) hypothetical protein 0.0064 0.0283 0.1713
Toxoplasma gondii exonuclease III APE 0.0018 0.0042 0.0142
Trypanosoma cruzi tubulin delta chain 0.006 0.0263 0.0849
Echinococcus granulosus Protein patched homolog 1 0.0043 0.0174 0.0414
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0038 0.0052
Mycobacterium tuberculosis Cell division protein FtsZ 0.006 0.0263 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0042 0.0014
Schistosoma mansoni hypothetical protein 0.0042 0.0166 0.0394
Brugia malayi Sex muscle abnormal protein 5 0.0016 0.003 0.0041
Echinococcus multilocularis Niemann Pick C1 protein 0.0145 0.0708 0.08
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.006 0.0263 0.0967
Schistosoma mansoni proto-oncogene tyrosine-protein kinase abl1 0.0016 0.003 0.0072
Schistosoma mansoni hypothetical protein 0.0037 0.014 0.0333
Echinococcus granulosus tubulin alpha chain 0.0258 0.1307 0.3112
Schistosoma mansoni ran 0.0022 0.0063 0.0149
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0063 0.0082
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0018 0.0042 0.01
Trypanosoma brucei epsilon tubulin 0.0139 0.0678 0.251
Brugia malayi TAR-binding protein 0.0065 0.029 0.04
Loa Loa (eye worm) hypothetical protein 0.001 0.0000094675 0.0001
Schistosoma mansoni tubulin subunit beta 0.0139 0.0678 0.1614
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0105 0.0378
Echinococcus multilocularis Tubulin beta 2C chain 0.0139 0.0678 0.0766
Echinococcus granulosus tyrosine protein kinase Src64B 0.0054 0.0228 0.0543
Echinococcus multilocularis tyrosine protein kinase Srms 0.0046 0.0186 0.021
Trypanosoma brucei beta tubulin 0.0139 0.0678 0.251
Onchocerca volvulus 0.001 0.0000094675 0.0000094675
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0038 0.0043
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1302 0.9965
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0014 0.0019 0.0021
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0073 0.0131
Echinococcus multilocularis tubulin beta 1 chain 0.0139 0.0678 0.0766
Brugia malayi alpha-tubulin 0.0258 0.1307 0.1802
Schistosoma mansoni transient receptor potential channel 0.0102 0.0484 0.1152
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0012 0.0071
Trypanosoma brucei alpha tubulin, putative 0.0079 0.036 0.1326
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0206 0.0284
Schistosoma mansoni hypothetical protein 0.0016 0.0027 0.0065
Trichomonas vaginalis tubulin beta chain, putative 0.0258 0.1307 1
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0000094675 0.0001
Leishmania major alpha tubulin 0.0258 0.1307 0.4783
Plasmodium vivax tubulin alpha chain, putative 0.0258 0.1307 0.4777
Loa Loa (eye worm) alpha-tubulin 0.0258 0.1307 0.7903
Echinococcus multilocularis tubulin alpha chain 0.0258 0.1307 0.1478
Trypanosoma cruzi epsilon tubulin, putative 0.0139 0.0678 0.2412
Schistosoma mansoni tubulin subunit alpha 0.0258 0.1307 0.3112
Trypanosoma brucei beta tubulin 0.0139 0.0678 0.251
Echinococcus granulosus tubulin delta chain 0.006 0.0263 0.0626
Trichomonas vaginalis tubulin alpha chain, putative 0.0079 0.036 0.2733
Giardia lamblia Alpha-tubulin 0.0258 0.1307 0.4783
Leishmania major GTP-binding protein, putative 0.0022 0.0063 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Trypanosoma cruzi epsilon tubulin, putative 0.0139 0.0678 0.2412
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Trichomonas vaginalis tubulin, putative 0.0139 0.0678 0.5175
Trichomonas vaginalis tubulin beta-1 chain, putative 0.006 0.0263 0.1993
Toxoplasma gondii histone lysine methyltransferase SET1 0.0107 0.0511 0.1888
Loa Loa (eye worm) ShTK domain-containing protein 0.0186 0.0928 0.5613
Trypanosoma cruzi PAB1-binding protein , putative 0.0051 0.0214 0.0666
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0042 0.0014
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0073 0.0258
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1302 0.9965
Brugia malayi hypothetical protein 0.0037 0.014 0.0193
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0063 0.0093
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0038 0.0229
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0073 0.0173
Schistosoma mansoni hypothetical protein 0.0324 0.1654 0.3938
Leishmania major alpha tubulin 0.0258 0.1307 0.4783
Echinococcus granulosus tubulin beta 1 chain 0.0139 0.0678 0.1614
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0000094675 0.0001
Echinococcus multilocularis protein patched 0.0043 0.0174 0.0197
Brugia malayi Common central domain of tyrosinase family protein 0.0186 0.0928 0.128
Onchocerca volvulus 0.0186 0.0928 0.0928
Brugia malayi Tubulin beta-1 chain 0.0139 0.0678 0.0935
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0054 0.0228 0.0543
Entamoeba histolytica tubulin family protein 0.0139 0.0678 0.5187
Schistosoma mansoni tyrosine kinase 0.0018 0.0042 0.01
Onchocerca volvulus 0.001 0.0000094675 0.0000094675
Toxoplasma gondii beta-tubulin, putative 0.0139 0.0678 0.251
Brugia malayi beta-tubulin, identical 0.0139 0.0678 0.0935
Trichomonas vaginalis tubulin beta chain, putative 0.0258 0.1307 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0144 0.0703 0.1674
Trichomonas vaginalis glucosylceramidase, putative 0.0178 0.0884 0.6752
Schistosoma mansoni tubulin subunit beta 0.0139 0.0678 0.1614
Brugia malayi Tubulin beta chain 0.006 0.0263 0.0363
Plasmodium falciparum tubulin epsilon chain, putative 0.0139 0.0678 0.2404
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0836 0.6384
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0012 0.0071
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0073 0.0134
Plasmodium vivax ataxin-2 like protein, putative 0.0051 0.0214 0.0655
Schistosoma mansoni tubulin subunit gamma 0.0139 0.0678 0.1614
Schistosoma mansoni hypothetical protein 0.0042 0.0166 0.0394
Onchocerca volvulus 0.001 0.0000094675 0.0000094675
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0012 0.0071
Plasmodium falciparum tubulin beta chain 0.0139 0.0678 0.2404
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0041 0.0231
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0063 0.0093
Brugia malayi Telomerase reverse transcriptase 0.1385 0.7254 1
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein 0.006 0.0263 0.0967
Brugia malayi RNA, U transporter 1 0.0086 0.04 0.0552
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Echinococcus multilocularis beta tubulin 0.0139 0.0678 0.0766
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0247
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1686 0.8845 1
Plasmodium vivax tubulin gamma chain, putative 0.0139 0.0678 0.2404
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0073 0.1462
Echinococcus multilocularis cpg binding protein 0.006 0.0261 0.0295
Echinococcus granulosus tubulin alpha 3 chain 0.0258 0.1307 0.3112
Loa Loa (eye worm) hypothetical protein 0.0011 0.0003 0.002
Onchocerca volvulus 0.0186 0.0928 0.0928
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0063 0.0379
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0041 0.5
Echinococcus multilocularis tyrosine protein kinase ABL1 0.026 0.1315 0.1486
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0012 0.0071
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0000094675 0.0001
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0836 0.6384
Loa Loa (eye worm) hypothetical protein 0.0018 0.0041 0.0247
Brugia malayi Tubulin gamma chain 0.0139 0.0678 0.0935
Echinococcus granulosus Tubulin beta 2C chain 0.0139 0.0678 0.1614
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1302 0.9965
Echinococcus granulosus tyrosine protein kinase Lyn 0.0054 0.0228 0.0543
Echinococcus granulosus tyrosine protein kinase Src42A 0.0054 0.0228 0.0543
Entamoeba histolytica protein kinase, putative 0.0038 0.0143 0.1092
Echinococcus granulosus beta tubulin 0.0139 0.0678 0.1614
Trichomonas vaginalis tubulin, putative 0.0079 0.036 0.2733
Trichomonas vaginalis ran, putative 0.0022 0.0063 0.0455
Trichomonas vaginalis glucosylceramidase, putative 0.0257 0.1302 0.9965
Echinococcus granulosus transient receptor potential gamma protein 0.0102 0.0484 0.1152
Leishmania major beta tubulin 0.0139 0.0678 0.2412
Entamoeba histolytica tubulin family protein 0.0139 0.0678 0.5187
Leishmania major alpha tubulin 0.0258 0.1307 0.4783
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0018 0.0038 0.0129
Echinococcus multilocularis importin subunit beta 1 0.003 0.0105 0.0119
Brugia malayi Niemann-Pick C1 protein precursor 0.0101 0.0479 0.066
Leishmania major beta tubulin 0.0139 0.0678 0.2412
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0055 0.0064
Loa Loa (eye worm) tubulin alpha 2 0.0119 0.0574 0.347
Echinococcus granulosus tubulin alpha chain 0.0258 0.1307 0.3112
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0073 0.0134
Loa Loa (eye worm) BEN-1 protein 0.0139 0.0678 0.4099
Treponema pallidum cell division protein FtsZ 0.006 0.0263 1
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0038 0.0001
Loa Loa (eye worm) hypothetical protein 0.0098 0.046 0.2779
Loa Loa (eye worm) tubulin beta-4 chain 0.0139 0.0678 0.4099
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0073 0.1462
Loa Loa (eye worm) TK/FER protein kinase 0.001 0.0000094675 0.0001
Loa Loa (eye worm) alpha-tubulin isotype 2 0.0198 0.0989 0.5978
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0073 0.1462
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0018 0.0038 0.0129
Brugia malayi Tyrosine-protein kinase abl-1 0.0154 0.0757 0.1043
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0042 0.0099
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0144 0.0703 0.0969
Mycobacterium leprae cell division protein FtsZ 0.006 0.0263 1
Schistosoma mansoni transient receptor potential channel 0.0068 0.0301 0.0717
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0012 0.0071
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0038 0.009
Trypanosoma brucei telomerase reverse transcriptase 0.052 0.2691 1
Echinococcus granulosus tyrosine kinase 0.0046 0.0186 0.0443
Echinococcus granulosus c src tyrosine kinase 0.0018 0.0042 0.01
Echinococcus granulosus Tubulin beta 2C chain 0.0139 0.0678 0.1614
Trypanosoma brucei epsilon tubulin 0.0139 0.0678 0.251
Mycobacterium ulcerans cell division protein FtsZ 0.006 0.0263 1
Echinococcus granulosus tubulin epsilon chain 0.0139 0.0678 0.1614
Leishmania major beta tubulin 0.0139 0.0678 0.2412
Schistosoma mansoni growth factor receptor-bound protein 0.0016 0.003 0.0072
Trichomonas vaginalis conserved hypothetical protein 0.006 0.0263 0.1993
Trichomonas vaginalis tubulin gamma chain, putative 0.0139 0.0678 0.5175
Onchocerca volvulus Glucosylceramidase homolog 0.0169 0.0836 0.0836
Schistosoma mansoni tubulin subunit alpha 0.0258 0.1307 0.3112
Schistosoma mansoni tyrosine kinase 0.0054 0.0228 0.0543
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0012 0.0071
Schistosoma mansoni hypothetical protein 0.0016 0.0027 0.0065
Loa Loa (eye worm) hypothetical protein 0.0198 0.0989 0.5978
Trichomonas vaginalis tubulin alpha chain, putative 0.0079 0.036 0.2733
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0027 0.0038
Plasmodium falciparum tubulin delta chain, putative 0.006 0.0263 0.0839
Plasmodium vivax tubulin beta chain, putative 0.0139 0.0678 0.2404
Plasmodium vivax telomerase reverse transcriptase, putative 0.052 0.2691 1
Loa Loa (eye worm) ShTK domain-containing protein 0.0186 0.0928 0.5613
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0016 0.003 0.0182
Brugia malayi Tubulin alpha chain 0.006 0.0263 0.0363
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Entamoeba histolytica hypothetical protein 0.0037 0.014 0.107
Trichomonas vaginalis glucosylceramidase, putative 0.0169 0.0836 0.6384
Brugia malayi Variant SH3 domain containing protein 0.0016 0.003 0.0041
Echinococcus granulosus alpha tubulin 0.0258 0.1307 0.3112
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0038 0.0265
Echinococcus multilocularis tyrosine protein kinase Blk 0.0046 0.0186 0.021
Echinococcus granulosus expressed conserved protein 0.0095 0.0446 0.1063
Giardia lamblia Telomerase catalytic subunit 0.052 0.2691 1
Leishmania major zeta tubulin, putative 0.006 0.0263 0.0849
Loa Loa (eye worm) hypothetical protein 0.0051 0.0214 0.1297
Leishmania major alpha tubulin 0.0258 0.1307 0.4783
Echinococcus multilocularis GPCR, family 2 0.0016 0.0027 0.0031
Schistosoma mansoni tar DNA-binding protein 0.0065 0.029 0.0692
Echinococcus granulosus mixed lineage leukemia protein mll 0.0014 0.0019 0.0045
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0042 0.0032
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0027 0.0031
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0054 0.0228 0.0258
Giardia lamblia Gamma tubulin 0.0139 0.0678 0.2412
Trichomonas vaginalis tubulin beta chain, putative 0.0139 0.0678 0.5175
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0073 0.0561
Brugia malayi tubulin alpha chain - mouse 0.0258 0.1307 0.1802
Echinococcus granulosus tyrosine protein kinase Fyn 0.0054 0.0228 0.0543
Plasmodium falciparum importin beta, putative 0.003 0.0105 0.0242
Toxoplasma gondii alpha tubulin TUBA1 0.0258 0.1307 0.485
Plasmodium falciparum ataxin-2 like protein, putative 0.0051 0.0214 0.0655
Trichomonas vaginalis tubulin gamma chain, putative 0.0139 0.0678 0.5175

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 5.5 uM Inhibition of human ABL by radiometric assay ChEMBL. 22369268
Ki (binding) > 10 uM Inhibition of human SRC by radiometric assay ChEMBL. 22369268

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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