Detailed information for compound 1658446

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 348.354 | Formula: C23H12N2O2
  • H donors: 0 H acceptors: 2 LogP: 4.55 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1c2nc3cc4ccccc4cc3c(=O)n2c2c1ccc1c2cccc1
  • InChi: 1S/C23H12N2O2/c26-21-17-10-9-13-5-3-4-8-16(13)20(17)25-22(21)24-19-12-15-7-2-1-6-14(15)11-18(19)23(25)27/h1-12H
  • InChiKey: RWOBLXLBMSPVKX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Plasmodium falciparum NADPH--cytochrome P450 reductase, putative 0.0043 0.0074 0.3033
Schistosoma mansoni cytochrome B5 0.0013 0.0001 0.0003
Giardia lamblia Fructose-bisphosphate aldolase 0.0353 0.0835 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.0055 0.0171
Echinococcus granulosus microtubule associated protein 2 0.0833 0.2012 0.6215
Trichomonas vaginalis CMGC family protein kinase 0.0274 0.0643 0.7623
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0043 0.0074 0.0597
Loa Loa (eye worm) hypothetical protein 0.0032 0.0048 0.0148
Plasmodium vivax NADPH-cytochrome p450 reductase, putative 0.0111 0.0243 1
Schistosoma mansoni hypothetical protein 0.0035 0.0055 0.0171
Brugia malayi Muscleblind-like protein 0.018 0.0412 0.1273
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.044 0.115
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0835 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.044 0.1358
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0323 0.0999
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0077 0.0531
Plasmodium falciparum histone acetyltransferase GCN5 0.0047 0.0086 0.3504
Echinococcus multilocularis expressed conserved protein 0.0112 0.0244 0.0638
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0175 0.0399 0.1044
Schistosoma mansoni hypothetical protein 0.041 0.0974 0.3009
Loa Loa (eye worm) hypothetical protein 0.0111 0.0243 0.0749
Loa Loa (eye worm) cytochrome b5 reductase 4 0.0013 0.0001 0.0003
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0043 0.0074 0.0515
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0175 0.0399 0.1232
Loa Loa (eye worm) acetyltransferase 0.0175 0.0399 0.1232
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.0707 0.2183
Onchocerca volvulus 0.0043 0.0077 0.2304
Mycobacterium tuberculosis Conserved protein 0.0043 0.0077 0.0076
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0077 0.0076
Trypanosoma brucei NADPH-cytochrome p450 reductase, putative 0.0111 0.0243 0.1699
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0101 0.0264
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0033 0.005 0.0154
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0063 0.0435
Onchocerca volvulus 0.0032 0.0048 0.144
Loa Loa (eye worm) hypothetical protein 0.0032 0.0048 0.0148
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0026 0.0177
Echinococcus multilocularis NADPH cytochrome P450 reductase 0.0111 0.0243 0.0635
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0063 0.0338
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0077 0.0626
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0077 0.0531
Echinococcus granulosus mitogen activated protein kinase 3 0.0274 0.0643 0.1985
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0077 0.0076
Leishmania major cytochrome P450 reductase, putative 0.0099 0.0212 0.1481
Brugia malayi acetyltransferase, GNAT family protein 0.0175 0.0399 0.1232
Schistosoma mansoni rab6-interacting 0.0024 0.0028 0.0088
Loa Loa (eye worm) hypothetical protein 0.0062 0.0123 0.0381
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.01 0.0263
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.017 0.0444
Leishmania major hypothetical protein, conserved 0.0043 0.0074 0.0515
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0101 0.0311
Trypanosoma brucei S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0043 0.0074 0.0515
Onchocerca volvulus 0.0033 0.005 0.15
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0085 0.0261
Brugia malayi mbt repeat family protein 0.0047 0.0085 0.0261
Echinococcus multilocularis Niemann Pick C1 protein 0.0119 0.0261 0.0684
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0063 0.0435
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0077 0.0626
Loa Loa (eye worm) FAD binding domain-containing protein 0.0111 0.0243 0.0749
Treponema pallidum flavodoxin 0.0043 0.0074 0.0659
Onchocerca volvulus 0.0029 0.0041 0.122
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.0055 0.0171
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0088
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0077 0.0679
Schistosoma mansoni polycystin 1-related 0.0024 0.0028 0.0088
Brugia malayi FAD binding domain containing protein 0.0069 0.0138 0.0427
Echinococcus multilocularis muscleblind protein 0.018 0.0412 0.1078
Loa Loa (eye worm) hypothetical protein 0.0032 0.0048 0.0148
Loa Loa (eye worm) diaphorase 0.0013 0.0001 0.0003
Loa Loa (eye worm) twinkle helicase 0.0133 0.0297 0.0917
Echinococcus multilocularis RUN 0.0024 0.0028 0.0074
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0063 0.0435
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0043 0.0074 0.0597
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0053 0.0101 0.0311
Onchocerca volvulus 0.0081 0.017 0.5096
Entamoeba histolytica type A flavoprotein, putative 0.0043 0.0074 0.0597
Loa Loa (eye worm) MBCTL1 0.0053 0.01 0.031
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0026 0.0175
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0022
Brugia malayi mbt repeat family protein 0.0047 0.0085 0.0261
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0048 0.0148
Loa Loa (eye worm) hypothetical protein 0.0081 0.017 0.0524
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.017 0.0524
Onchocerca volvulus Peroxidasin homolog 0.0032 0.0048 0.144
Treponema pallidum fructose-bisphosphate aldolase 0.0353 0.0835 0.7495
Plasmodium vivax importin-beta 2, putative 0.0028 0.0039 0.1573
Plasmodium vivax multidomain scavenger receptor, putative 0.0024 0.0028 0.1133
Loa Loa (eye worm) hypothetical protein 0.018 0.0412 0.1273
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0028 0.0074
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0063 0.0456
Loa Loa (eye worm) indoleamine 2,3-dioxygenase 0.1333 0.3238 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0077 0.0237
Echinococcus granulosus expressed conserved protein 0.0112 0.0244 0.0753
Loa Loa (eye worm) hypothetical protein 0.0032 0.0048 0.0148
Mycobacterium ulcerans hypothetical protein 0.0043 0.0077 0.0679
Echinococcus multilocularis protein dispatched 1 0.0058 0.0113 0.0295
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.0055 0.0171
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0101 0.0311
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0016 0.0009 0.0027
Entamoeba histolytica type A flavoprotein, putative 0.0043 0.0074 0.0597
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0063 0.0456
Schistosoma mansoni importin beta-1 0.0028 0.0039 0.0121
Loa Loa (eye worm) hypothetical protein 0.0051 0.0095 0.0294
Brugia malayi FAD binding domain containing protein 0.0111 0.0243 0.0749
Entamoeba histolytica hypothetical protein 0.0043 0.0077 0.0625
Leishmania major mitochondrial DNA polymerase beta 0.0593 0.1423 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0048 0.0148
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0063 0.2559
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0048 0.0148
Echinococcus multilocularis lamin 0.0033 0.005 0.0131
Loa Loa (eye worm) hypothetical protein 0.0032 0.0048 0.0148
Schistosoma mansoni rab6-interacting 0.0024 0.0028 0.0088
Loa Loa (eye worm) hypothetical protein 0.0075 0.0155 0.0478
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0274 0.0643 0.4512
Brugia malayi MH2 domain containing protein 0.0144 0.0323 0.0999
Loa Loa (eye worm) hypothetical protein 0.011 0.024 0.0741
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0039 0.0267
Brugia malayi MAP kinase sur-1 0.0274 0.0643 0.1985
Plasmodium falciparum nitric oxide synthase, putative 0.0111 0.0243 1
Echinococcus granulosus cpg binding protein 0.003 0.0045 0.0138
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0063 0.2559
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0083 0.0174 0.1219
Brugia malayi Importin beta-1 subunit 0.0028 0.0039 0.0121
Trypanosoma cruzi DNA repair protein, putative 0.004 0.0068 0.0473
Onchocerca volvulus Huntingtin homolog 0.0148 0.0333 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0053 0.0101 0.0311
Schistosoma mansoni lamin 0.0033 0.005 0.0154
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.0835 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0048 0.0148
Trypanosoma cruzi Flavodoxin/Radical SAM superfamily/Wyosine base formation, putative 0.0043 0.0074 0.0515
Onchocerca volvulus 0.0024 0.0028 0.0855
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0048 0.0148
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0083 0.0174 0.1219
Echinococcus granulosus methionine synthase reductase 0.0069 0.0138 0.0427
Schistosoma mansoni hypothetical protein 0.0075 0.0155 0.0478
Echinococcus multilocularis Polycystic kidney disease protein 0.0024 0.0028 0.0074
Mycobacterium ulcerans formate dehydrogenase H FdhF 0.0111 0.0243 0.2171
Schistosoma mansoni microtubule-associated protein tau 0.0833 0.2012 0.6215
Schistosoma mansoni hypothetical protein 0.0035 0.0055 0.0171
Trichomonas vaginalis sulfite reductase, putative 0.0111 0.0243 0.2678
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0063 0.0556
Loa Loa (eye worm) hypothetical protein 0.0032 0.0048 0.0148
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0085 0.254
Echinococcus multilocularis indoleamine 2,3 dioxygenase 2 0.1333 0.3238 0.8471
Schistosoma mansoni hypothetical protein 0.0024 0.0028 0.0088
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0028 0.0088
Brugia malayi diaphorase 0.0013 0.0001 0.0003
Giardia lamblia Histone acetyltransferase GCN5 0.0047 0.0086 0.1015
Onchocerca volvulus Dual oxidase homolog 0.0032 0.0048 0.144
Trypanosoma cruzi NADPH--cytochrome P450 reductase, putative 0.0043 0.0074 0.0515
Brugia malayi indoleamine 2,3-dioxygenase 0.1333 0.3238 1
Schistosoma mansoni hypothetical protein 0.0035 0.0055 0.0171
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0041 0.0125
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0835 1
Schistosoma mansoni loxhd1 0.0024 0.0028 0.0088
Brugia malayi beta-lactamase family protein 0.0043 0.0077 0.0237
Toxoplasma gondii hypothetical protein 0.0096 0.0204 0.317
Plasmodium falciparum importin beta, putative 0.0028 0.0039 0.1573
Giardia lamblia Kinase, CMGC MAPK 0.0274 0.0643 0.7694
Onchocerca volvulus 0.0024 0.0028 0.0855
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0119 0.0261 0.291
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0063 0.0062
Brugia malayi intermediate filament protein 0.0033 0.005 0.0154
Mycobacterium tuberculosis Conserved protein 0.0043 0.0077 0.0076
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0323 0.0999
Schistosoma mansoni Replicative DNA helicase 0.0467 0.1114 0.344
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0048 0.0148
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0077 0.02
Loa Loa (eye worm) hypothetical protein 0.0033 0.005 0.0154
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0274 0.0643 0.4512
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.0026 0.0226
Echinococcus granulosus histone acetyltransferase KAT2B 0.0051 0.0096 0.0297
Loa Loa (eye worm) FAD binding domain-containing protein 0.0069 0.0138 0.0427
Trypanosoma cruzi p450 reductase, putative 0.0111 0.0243 0.1699
Echinococcus granulosus dnaJ subfamily B 0.041 0.0974 0.3009
Plasmodium falciparum LCCL domain-containing protein 0.0024 0.0028 0.1133
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0274 0.0643 0.4512
Mycobacterium ulcerans recombinase A 0.013 0.0289 0.2592
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0074 0.3033
Mycobacterium leprae PROBABLE REPLICATIVE DNA HELICASE DNAB replicative DNA helicase 0.0467 0.1114 0.328
Treponema pallidum recombinase A 0.013 0.0289 0.2592
Echinococcus granulosus Protein patched homolog 1 0.0051 0.0095 0.0294
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.0055 0.0171
Loa Loa (eye worm) hypothetical protein 0.0032 0.0048 0.0148
Entamoeba histolytica type A flavoprotein, putative 0.0043 0.0074 0.0597
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0083 0.0174 0.1219
Schistosoma mansoni diflavin oxidoreductase 0.0055 0.0105 0.0325
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0077 0.0626
Loa Loa (eye worm) intermediate filament protein 0.0033 0.005 0.0154
Loa Loa (eye worm) hypothetical protein 0.0035 0.0055 0.0171
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0077 0.0237
Schistosoma mansoni hypothetical protein 0.0035 0.0055 0.0171
Mycobacterium ulcerans hypothetical protein 0.0312 0.0736 0.6601
Brugia malayi hypothetical protein 0.0024 0.0028 0.0088
Entamoeba histolytica hypothetical protein 0.0043 0.0077 0.0625
Loa Loa (eye worm) hypothetical protein 0.018 0.0412 0.1273
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0593 0.1423 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0083 0.0174 0.1219
Brugia malayi CHE-14 protein 0.0051 0.0095 0.0294
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0077 0.0201
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0077 0.0237
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0835 1
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0077 0.3128
Echinococcus granulosus geminin 0.0205 0.0472 0.1457
Entamoeba histolytica type A flavoprotein, putative 0.0043 0.0074 0.0597
Entamoeba histolytica hypothetical protein 0.0043 0.0077 0.0625
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0835 1
Plasmodium vivax flavodoxin domain containing protein 0.0099 0.0212 0.8717
Leishmania major NADPH-cytochrome p450 reductase-like protein 0.0111 0.0243 0.1699
Brugia malayi Doublecortin family protein 0.0024 0.0028 0.0088
Onchocerca volvulus Peroxidasin homolog 0.0032 0.0048 0.144
Loa Loa (eye worm) doublecortin family protein 0.0024 0.0028 0.0088
Trichomonas vaginalis CMGC family protein kinase 0.0274 0.0643 0.7623
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0077 0.0626
Giardia lamblia Hypothetical protein 0.0099 0.0212 0.2525
Echinococcus multilocularis mitogen activated protein kinase 0.0274 0.0643 0.1682
Brugia malayi Blistered cuticle protein 3 0.0032 0.0048 0.0148
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0274 0.0643 0.4512
Trypanosoma brucei recA bacterial DNA recombination protein, putative 0.004 0.0068 0.0473
Mycobacterium ulcerans beta-lactamase 0.0043 0.0077 0.0679
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.0026 0.0025
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0281 0.0658 0.4618
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0835 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.011 0.024 0.0741
Loa Loa (eye worm) hypothetical protein 0.0015 0.0007 0.0022
Echinococcus granulosus Polycystic kidney disease protein 0.0024 0.0028 0.0088
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0026 0.0391
Schistosoma mansoni peroxidasin 0.0032 0.0048 0.0148
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.011 0.024 0.0741
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0077 0.0626
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0085 0.0261
Schistosoma mansoni hypothetical protein 0.0049 0.0091 0.028
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.01 0.0263
Echinococcus granulosus intermediate filament protein 0.0033 0.005 0.0154
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0063 0.0165
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0274 0.0643 0.4512
Loa Loa (eye worm) beta-lactamase 0.0043 0.0077 0.0237
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0051 0.0096 0.1483
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.017 0.0524
Onchocerca volvulus Chorion peroxidase homolog 0.0032 0.0048 0.144
Loa Loa (eye worm) hypothetical protein 0.0024 0.0028 0.0088
Schistosoma mansoni lipoxygenase 0.01 0.0214 0.0661
Leishmania major importin beta-1 subunit, putative 0.0023 0.0026 0.0175
Schistosoma mansoni cpg binding protein 0.0029 0.0041 0.0125
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0172 0.0393 0.0392
Mycobacterium ulcerans lipase LipD 0.0043 0.0077 0.0679
Plasmodium falciparum S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase, putative 0.0043 0.0074 0.3033
Schistosoma mansoni hypothetical protein 0.0205 0.0472 0.1457
Brugia malayi flavodoxin family protein 0.0043 0.0074 0.023
Echinococcus multilocularis geminin 0.0205 0.0472 0.1234
Loa Loa (eye worm) hypothetical protein 0.0028 0.0039 0.0121
Echinococcus granulosus cytochrome b5 reductase 4 0.0013 0.0001 0.0003
Echinococcus granulosus sterol regulatory element binding protein 0.0051 0.0095 0.0294
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.01 0.031
Echinococcus granulosus lamin dm0 0.0033 0.005 0.0154
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0274 0.0643 0.4512
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1572 0.3822 1
Schistosoma mansoni hypothetical protein 0.1333 0.3238 1
Echinococcus multilocularis GPCR, family 2 0.0035 0.0055 0.0145
Toxoplasma gondii exonuclease III APE 0.0038 0.0063 0.0964
Brugia malayi CXXC zinc finger family protein 0.0029 0.0041 0.0125
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0157 0.0356 0.0931
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0085 0.0221
Schistosoma mansoni cpg binding protein 0.003 0.0045 0.0138
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0039 0.0102
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0077 0.0531
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0077 0.0237
Schistosoma mansoni 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase 0.0069 0.0138 0.0427
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0085 0.0261
Onchocerca volvulus 0.0033 0.005 0.15
Toxoplasma gondii flavodoxin domain-containing protein 0.0055 0.0105 0.1625
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0593 0.1423 1
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0085 0.0261
Brugia malayi Niemann-Pick C1 protein precursor 0.0119 0.0261 0.0808
Wolbachia endosymbiont of Brugia malayi recombinase A 0.013 0.0289 0.2421
Treponema pallidum replicative DNA helicase (dnaB) 0.0467 0.1114 1
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0043 0.0074 0.0597
Echinococcus granulosus peroxidasin 0.0032 0.0048 0.0148
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0053 0.0101 0.0311
Echinococcus granulosus cytochrome b5 reductase 4 0.0013 0.0001 0.0003
Echinococcus granulosus mitogen activated protein kinase 0.0274 0.0643 0.1985
Trichomonas vaginalis CMGC family protein kinase 0.0274 0.0643 0.7623
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0593 0.1423 1
Entamoeba histolytica hypothetical protein 0.0023 0.0026 0.0002
Loa Loa (eye worm) hypothetical protein 0.0043 0.0077 0.0237
Leishmania major p450 reductase, putative 0.0111 0.0243 0.1699
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0142 0.0319 0.0835
Trichomonas vaginalis NADPH cytochrome P450, putative 0.0043 0.0074 0.0597
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0281 0.0658 0.4618
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0111 0.0243 0.1699
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0111 0.0243 0.1699
Echinococcus multilocularis lipoxygenase domain containing protein 0.0024 0.0028 0.0074
Schistosoma mansoni lipoxygenase 0.0142 0.0319 0.0986
Brugia malayi RNA, U transporter 1 0.008 0.0166 0.0514
Schistosoma mansoni ap endonuclease 0.0038 0.0063 0.0194
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0077 0.0076
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0274 0.0643 1
Brugia malayi Latrophilin receptor protein 2 0.0035 0.0055 0.0171
Echinococcus granulosus lamin 0.0033 0.005 0.0154
Onchocerca volvulus Huntingtin homolog 0.0148 0.0333 1
Echinococcus granulosus importin subunit beta 1 0.0028 0.0039 0.0121
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0017 0.0013 0.004
Schistosoma mansoni NADH-cytochrome B5 reductase 0.0013 0.0001 0.0003
Brugia malayi Intermediate filament tail domain containing protein 0.0033 0.005 0.0154
Loa Loa (eye worm) hypothetical protein 0.0047 0.0085 0.0261
Trichomonas vaginalis bromodomain-containing protein, putative 0.0051 0.0096 0.0868
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0063 0.0194
Loa Loa (eye worm) hypothetical protein 0.0032 0.0048 0.0148
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0085 0.0261
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0077 0.0236
Echinococcus granulosus histone acetyltransferase KAT2B 0.017 0.0387 0.1195
Loa Loa (eye worm) flavodoxin family protein 0.0043 0.0074 0.023
Trichomonas vaginalis CMGC family protein kinase 0.0274 0.0643 0.7623
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0835 1
Mycobacterium leprae Probable lipase LipE 0.0043 0.0077 0.0152
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0048 0.0148
Onchocerca volvulus 0.0047 0.0085 0.254
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0048 0.0148
Schistosoma mansoni hypothetical protein 0.0043 0.0077 0.0236
Schistosoma mansoni lamin 0.0033 0.005 0.0154
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0077 0.0237
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0835 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.0055 0.0145
Mycobacterium leprae Conserved hypothetical protein 0.1376 0.3342 1
Trichomonas vaginalis conserved hypothetical protein 0.0051 0.0095 0.0854
Toxoplasma gondii ABC1 family protein 0.0043 0.0077 0.1178
Brugia malayi beta-lactamase family protein 0.0043 0.0077 0.0237
Schistosoma mansoni serine/threonine protein kinase 0.0274 0.0643 0.1985
Onchocerca volvulus 0.0032 0.0048 0.144
Echinococcus multilocularis Niemann Pick C1 protein 0.017 0.0387 0.1011
Trichomonas vaginalis NADPH fad oxidoreductase, putative 0.0099 0.0212 0.2295
Echinococcus granulosus Niemann Pick C1 protein 0.017 0.0387 0.1194
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0121 0.0266 0.0821
Trypanosoma brucei NADPH-dependent diflavin oxidoreductase 1 0.0111 0.0243 0.1699
Schistosoma mansoni hypothetical protein 0.0049 0.0091 0.028
Echinococcus multilocularis mitogen activated protein kinase 3 0.0274 0.0643 0.1682
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0353 0.0835 1
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0039 0.0592
Echinococcus multilocularis microtubule associated protein 2 0.0833 0.2012 0.5265
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0063 0.0435
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0039 0.0267
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0063 0.0194
Schistosoma mansoni hypothetical protein 0.0291 0.0684 0.2114
Brugia malayi cytoplasmic intermediate filament protein 0.0017 0.0013 0.004
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0048 0.0148
Brugia malayi Peroxidasin 0.0032 0.0048 0.0148
Echinococcus multilocularis protein patched 0.0051 0.0095 0.0249
Echinococcus multilocularis peroxidasin 0.0032 0.0048 0.0125
Loa Loa (eye worm) hypothetical protein 0.0148 0.0333 0.1027
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0026 0.0226
Trypanosoma brucei protein kinase, putative 0.0274 0.0643 0.4512
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0063 0.0556
Onchocerca volvulus Peroxidase homolog 0.0032 0.0048 0.144
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0026 0.0177
Onchocerca volvulus 0.0032 0.0048 0.144
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0026 0.1039
Echinococcus multilocularis muscleblind protein 1 0.018 0.0412 0.1078
Brugia malayi Cytochrome b5-like Heme/Steroid binding domain containing protein 0.0013 0.0001 0.0003
Echinococcus granulosus NADPH dependent diflavin oxidoreductase 1 0.0111 0.0243 0.0749
Loa Loa (eye worm) hypothetical protein 0.0032 0.0048 0.0148
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.01 0.031
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0053 0.0101 0.0264
Echinococcus multilocularis NADPH dependent diflavin oxidoreductase 1 0.0111 0.0243 0.0635
Schistosoma mansoni cpg binding protein 0.003 0.0045 0.0138
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.0651 0.065
Loa Loa (eye worm) blistered cuticle protein 3 0.0032 0.0048 0.0148
Schistosoma mansoni hypothetical protein 0.0049 0.0091 0.028
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.017 0.0524
Mycobacterium tuberculosis RecA protein (recombinase A) [contains: endonuclease PI-MTUI (MTU RecA intein)]. 0.3756 0.9176 0.9176
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0051 0.0096 0.1483
Echinococcus multilocularis lamin dm0 0.0033 0.005 0.0131
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0281 0.0658 0.4618
Loa Loa (eye worm) hypothetical protein 0.0032 0.0048 0.0148
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0142 0.0319 0.0986
Onchocerca volvulus 0.0013 0.0001 0.0032
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0077 0.0237
Echinococcus granulosus NADPH cytochrome P450 reductase 0.0111 0.0243 0.0749
Echinococcus multilocularis dnaJ subfamily B 0.041 0.0974 0.2549
Echinococcus granulosus Niemann Pick C1 protein 0.0119 0.0261 0.0808
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0077 0.0076
Trichomonas vaginalis esterase, putative 0.0043 0.0077 0.0626
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0051 0.0096 0.0868
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0077 0.0236
Entamoeba histolytica hypothetical protein 0.0043 0.0077 0.0625
Onchocerca volvulus Peroxidase homolog 0.0032 0.0048 0.144
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0102 0.0219 0.1533
Brugia malayi hypothetical protein 0.0032 0.0048 0.0148
Brugia malayi flavodoxin family protein 0.0111 0.0243 0.0749
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0077 0.0679
Entamoeba histolytica acetyltransferase, GNAT family 0.0047 0.0086 0.0738
Echinococcus granulosus GPCR family 2 0.0035 0.0055 0.0171
Schistosoma mansoni hypothetical protein 0.0049 0.0091 0.028
Echinococcus granulosus NADH cytochrome b5 reductase 3 0.0013 0.0001 0.0003
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0026 0.0226
Schistosoma mansoni cytochrome P450 reductase 0.0111 0.0243 0.0749
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0101 0.0311
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0077 0.0152
Mycobacterium leprae RECA PROTEIN (RECOMBINASE A) [CONTAINS: Mle RECA INTEIN]. 0.013 0.0289 0.0794
Brugia malayi beta-lactamase 0.0043 0.0077 0.0237
Loa Loa (eye worm) hypothetical protein 0.0053 0.01 0.031
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0077 0.0076
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0063 0.0456
Echinococcus granulosus lipoxygenase domain containing protein 0.0024 0.0028 0.0088
Loa Loa (eye worm) hypothetical protein 0.0043 0.0077 0.0237
Loa Loa (eye worm) hypothetical protein 0.0043 0.0077 0.0237
Echinococcus granulosus snurportin 1 0.0301 0.0707 0.2183
Schistosoma mansoni hypothetical protein 0.1333 0.3238 1
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0085 0.0221
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.0055 0.0145
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0172 0.0393 0.1105
Leishmania major hypothetical protein, conserved 0.0043 0.0077 0.0531
Trypanosoma cruzi cytochrome P450 reductase, putative 0.0111 0.0243 0.1699
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0353 0.0835 1
Trypanosoma cruzi DNA repair protein, putative 0.004 0.0068 0.0473
Echinococcus multilocularis musashi 0.0033 0.005 0.0131
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.0026 0.0226
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.012 0.037
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.0155 0.0478
Onchocerca volvulus 0.0043 0.0077 0.2304
Schistosoma mansoni peroxidasin 0.0032 0.0048 0.0148
Echinococcus multilocularis cytochrome b5 reductase 4 0.0013 0.0001 0.0003
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0085 0.0261
Loa Loa (eye worm) hypothetical protein 0.0016 0.0009 0.0027
Loa Loa (eye worm) hypothetical protein 0.0119 0.0261 0.0808
Schistosoma mansoni NADPH flavin oxidoreductase 0.0056 0.0107 0.0332
Mycobacterium tuberculosis Conserved protein 0.0043 0.0077 0.0076
Schistosoma mansoni hypothetical protein 0.0205 0.0472 0.1457
Brugia malayi Calcitonin receptor-like protein seb-1 0.011 0.024 0.0741
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0274 0.0643 0.4512
Echinococcus multilocularis snurportin 1 0.0301 0.0707 0.1849
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0016 0.0009 0.0023
Schistosoma mansoni intermediate filament proteins 0.0033 0.005 0.0154
Chlamydia trachomatis replicative DNA helicase 0.0467 0.1114 1
Echinococcus multilocularis methionine synthase reductase 0.0069 0.0138 0.0362
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0274 0.0643 0.1985
Echinococcus multilocularis NADH cytochrome b5 reductase 3 0.0013 0.0001 0.0003
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.01 0.031
Onchocerca volvulus 0.0043 0.0077 0.2304
Brugia malayi hypothetical protein 0.0024 0.0028 0.0088
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0051 0.0095 0.0294
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0051 0.0096 0.3939
Loa Loa (eye worm) hypothetical protein 0.0043 0.0077 0.0237
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0077 0.0076
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0063 0.0194
Loa Loa (eye worm) hypothetical protein 0.0148 0.0333 0.1027
Entamoeba histolytica type A flavoprotein, putative 0.0043 0.0074 0.0597
Giardia lamblia Nitric oxide synthase, inducible 0.0099 0.0212 0.2525
Echinococcus granulosus nuclear factor of activated T cells 5 0.0157 0.0356 0.1099
Wolbachia endosymbiont of Brugia malayi replicative DNA helicase 0.0467 0.1114 1
Echinococcus granulosus indoleamine 23 dioxygenase 2 0.1333 0.3238 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0172 0.0393 0.3519
Echinococcus multilocularis sterol regulatory element binding protein 0.0051 0.0095 0.0249
Echinococcus granulosus RUN 0.0024 0.0028 0.0088
Brugia malayi hypothetical protein 0.0148 0.0333 0.1027
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0026 0.1039
Toxoplasma gondii histone lysine methyltransferase SET1 0.0059 0.0114 0.1762
Loa Loa (eye worm) hypothetical protein 0.0032 0.0048 0.0148
Chlamydia trachomatis sulfite reductase 0.0069 0.0138 0.1234
Loa Loa (eye worm) hypothetical protein 0.0032 0.0048 0.015
Echinococcus granulosus muscleblind protein 0.018 0.0412 0.1273
Schistosoma mansoni patched 1 0.0051 0.0095 0.0294
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0077 0.0076
Schistosoma mansoni hypothetical protein 0.0301 0.0707 0.2183
Loa Loa (eye worm) hypothetical protein 0.0043 0.0077 0.0237
Brugia malayi hypothetical protein 0.0043 0.0077 0.0236
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.01 0.031
Schistosoma mansoni ap endonuclease 0.0038 0.0063 0.0194
Toxoplasma gondii flavodoxin domain-containing protein 0.0055 0.0105 0.1625
Trypanosoma brucei NADPH--cytochrome P450 reductase, putative 0.0111 0.0243 0.1699
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0053 0.0101 0.0311
Echinococcus multilocularis cpg binding protein 0.003 0.0045 0.0117
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0063 0.0741
Mycobacterium ulcerans replicative DNA helicase DnaB 0.0467 0.1114 1
Chlamydia trachomatis recombinase RecA 0.013 0.0289 0.2592
Mycobacterium tuberculosis Conserved hypothetical protein 0.0312 0.0736 0.0735
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0026 0.0391
Trypanosoma cruzi NADPH-dependent FMN/FAD containing oxidoreductase, putative 0.0111 0.0243 0.1699
Brugia malayi Animal haem peroxidase family protein 0.0032 0.0048 0.0148
Loa Loa (eye worm) animal heme peroxidase 0.0032 0.0048 0.0148
Loa Loa (eye worm) hypothetical protein 0.0032 0.0048 0.0148

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 34.93 uM Cytotoxicity against human T47D cells after 72 hrs by MTT assay ChEMBL. 22819942
Inhibition (binding) = 19.05 % Inhibition of human DNA topoisomerase 2alpha-mediated relaxation of supercoiled pBR322 DNA at 20 uM after 30 mins by agarose gel electrophoretic analysis ChEMBL. 22819942
Inhibition (binding) = 53.45 % Inhibition of human DNA topoisomerase 2alpha-mediated relaxation of supercoiled pBR322 DNA at 100 uM after 30 mins by agarose gel electrophoretic analysis ChEMBL. 22819942

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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