Detailed information for compound 1659187

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 454.588 | Formula: C23H30N6O2S
  • H donors: 1 H acceptors: 5 LogP: 2.26 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1(CC1)NC(=O)[C@@H]1CCCC[C@H]1C(=O)N1CCN(CC1)c1ncc(s1)C(C#N)(C)C
  • InChi: 1S/C23H30N6O2S/c1-22(2,14-24)18-13-26-21(32-18)29-11-9-28(10-12-29)20(31)17-6-4-3-5-16(17)19(30)27-23(15-25)7-8-23/h13,16-17H,3-12H2,1-2H3,(H,27,30)/t16-,17-/m1/s1
  • InChiKey: GVFZKOCFOOBUQV-IAGOWNOFSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL References
Homo sapiens cathepsin B Starlite/ChEMBL References
Homo sapiens cathepsin S Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL References
Homo sapiens cathepsin K Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 3 Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin CPL Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Neospora caninum Cathepsin L, related Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Cryptosporidium parvum cryptopain - cysteine proteinase secreted, possible transmembrane domain near N-terminus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi cathepsin B-like cysteine proteinase Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni SmCB2 peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin L-like proteinase precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K01363 cathepsin B [EC3.4.22.1], putative Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-4 Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l1 Get druggable targets OG5_126607 All targets in OG5_126607
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania donovani cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium falciparum cysteine proteinase falcipain 2a Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) ctsf protein Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Cryptosporidium hominis cryptopain precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium yoelii berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Plasmodium knowlesi knowpain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma cruzi cysteine peptidase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium berghei berghepain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) fibroinase Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin L cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) papain family cysteine protease containing protein Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium falciparum cysteine proteinase falcipain 2b Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase C (CPC), putative,CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like, putative Get druggable targets OG5_127800 All targets in OG5_127800
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania braziliensis cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Theileria parva cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Plasmodium vivax vivapain-2 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Toxoplasma gondii cathepsin B Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin B-like peptidase (C01 family) Get druggable targets OG5_127800 All targets in OG5_127800
Brugia malayi Cathepsin L-like precursor Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania donovani cysteine peptidase A (CBA) Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei gambiense cysteine peptidase precursor,cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cysteine peptidase C (CPC), putative Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Giardia lamblia Cathepsin B precursor Get druggable targets OG5_127800 All targets in OG5_127800
Plasmodium knowlesi knowpain-3 Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma mansoni cathepsin F (C01 family) Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin l cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana cathepsin L-like protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma cruzi cruzipain precursor, putative Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Schistosoma japonicum expressed protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase C (CPC) Get druggable targets OG5_127800 All targets in OG5_127800
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus multilocularis cathepsin L cysteine protease Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K01373 cathepsin F [EC3.4.22.41], putative Get druggable targets OG5_126607 All targets in OG5_126607
Echinococcus granulosus cathepsin b Get druggable targets OG5_127800 All targets in OG5_127800
Entamoeba histolytica cysteine proteinase, putative Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania infantum cysteine peptidase A (CPA) Get druggable targets OG5_126607 All targets in OG5_126607
Entamoeba histolytica cysteine protease, putative Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania major cathepsin L-like protease Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Trypanosoma congolense cysteine peptidase, Clan CA, family C1, Cathepsin L-like Get druggable targets OG5_126607 All targets in OG5_126607
Schistosoma japonicum Cathepsin B-like cysteine proteinase precursor, putative Get druggable targets OG5_127800 All targets in OG5_127800
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin F homolog Get druggable targets OG5_126607 All targets in OG5_126607
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase Get druggable targets OG5_126607 All targets in OG5_126607
Onchocerca volvulus Cathepsin L homolog Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania mexicana Get druggable targets OG5_126607 All targets in OG5_126607
Leishmania braziliensis cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like Get druggable targets OG5_127800 All targets in OG5_127800
Neospora caninum Cathepsin B-like protease (Precursor), related Get druggable targets OG5_127800 All targets in OG5_127800
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum dipeptidyl aminopeptidase 1 cathepsin B 339 aa 368 aa 26.9 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin K 329 aa 349 aa 33.2 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Plasmodium falciparum cysteine proteinase falcipain 1 cathepsin S 281 aa 226 aa 34.1 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis cathepsin L cysteine protease 0.0059 0.1605 0.2385
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0523 0.0343
Echinococcus multilocularis cathepsin L 0.0033 0.0523 0.0682
Loa Loa (eye worm) hypothetical protein 0.0049 0.1176 0.1826
Leishmania major cathepsin L-like protease 0.0059 0.1605 0.8437
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1605 0.8189
Brugia malayi beta-lactamase 0.0041 0.0864 0.0898
Leishmania major cathepsin L-like protease 0.0059 0.1605 0.8437
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1605 0.8189
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.1605 0.2385
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0059 0.1605 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1605 0.8189
Schistosoma mansoni cathepsin F (C01 family) 0.0059 0.1605 0.2385
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1605 0.8189
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0864 0.1218
Brugia malayi Cathepsin L-like precursor 0.0059 0.1605 0.2108
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0033 0.0523 0.0343
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0026 0.023 0.022
Trypanosoma cruzi cysteine peptidase, putative 0.0033 0.0523 0.0343
Loa Loa (eye worm) cytochrome P450 family protein 0.0063 0.1782 0.2767
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0864 0.2575
Brugia malayi Cathepsin L-like precursor 0.0059 0.1605 0.2108
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0059 0.1605 0.2385
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0065 0.1844 0.2762
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1605 0.8189
Leishmania major cathepsin L-like protease 0.0059 0.1605 0.8437
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1605 0.8189
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.1605 0.2108
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1605 0.8437
Schistosoma mansoni hypothetical protein 0.0023 0.014 0.0078
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0059 0.1605 0.8189
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1605 0.8189
Toxoplasma gondii cathepsin CPL 0.0059 0.1605 0.7561
Brugia malayi MH2 domain containing protein 0.0136 0.479 0.7304
Brugia malayi Cytochrome P450 family protein 0.0063 0.1782 0.2397
Echinococcus multilocularis cysteine protease 0.0059 0.1605 0.2385
Leishmania major cathepsin L-like protease 0.0059 0.1605 0.8437
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1605 0.8189
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.0523 0.0682
Brugia malayi Cathepsin L-like precursor 0.0041 0.0868 0.0904
Onchocerca volvulus 0.0059 0.1605 1
Onchocerca volvulus 0.0059 0.1605 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1605 0.8437
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0868 0.2606
Echinococcus granulosus fetal alzheimer antigen falz 0.0026 0.023 0.022
Brugia malayi Bromodomain containing protein 0.0044 0.0972 0.1074
Loa Loa (eye worm) hypothetical protein 0.0057 0.1516 0.2353
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.014 0.0217
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1605 0.8437
Entamoeba histolytica cysteine protease, putative 0.0059 0.1605 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.1979 0.2974
Schistosoma mansoni hypothetical protein 0.0039 0.0773 0.1075
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0864 0.2575
Brugia malayi Cathepsin L-like precursor 0.0059 0.1605 0.2108
Loa Loa (eye worm) hypothetical protein 0.0039 0.0773 0.12
Entamoeba histolytica cysteine proteinase, putative 0.0041 0.0868 0.3182
Echinococcus granulosus cathepsin l1 0.0041 0.0868 0.1224
Brugia malayi Cathepsin L-like precursor 0.0041 0.0868 0.0904
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0864 0.134
Loa Loa (eye worm) hypothetical protein 0.0176 0.6442 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0041 0.0862 0.1216
Brugia malayi cathepsin B-like cysteine proteinase 0.0176 0.6442 1
Giardia lamblia Cathepsin B precursor 0.0065 0.1844 0.5
Onchocerca volvulus 0.0059 0.1605 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0864 0.134
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.1605 0.2108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1605 0.8189
Loa Loa (eye worm) hypothetical protein 0.0046 0.1086 0.1686
Schistosoma mansoni transcription factor LCR-F1 0.0041 0.0862 0.1216
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1605 0.8437
Trypanosoma brucei cysteine peptidase C (CPC) 0.0065 0.1844 1
Plasmodium vivax vivapain-2 0.0059 0.1605 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0868 0.1347
Entamoeba histolytica hypothetical protein 0.0041 0.0862 0.3133
Brugia malayi Bromodomain containing protein 0.0085 0.27 0.3894
Trypanosoma cruzi cruzipain precursor, putative 0.0059 0.1605 0.2108
Entamoeba histolytica hypothetical protein 0.0041 0.0862 0.3133
Loa Loa (eye worm) CYP4Cod1 0.0028 0.0313 0.0486
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0864 0.3145
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1605 0.8189
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.6442 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0041 0.086 0.1212
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1605 0.8189
Entamoeba histolytica hypothetical protein 0.0041 0.0862 0.3133
Giardia lamblia Cathepsin B precursor 0.0065 0.1844 0.5
Echinococcus granulosus cathepsin L cysteine protease 0.0033 0.0523 0.0682
Echinococcus multilocularis cathepsin b 0.0176 0.6442 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1605 0.8189
Onchocerca volvulus 0.0059 0.1605 1
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.1605 0.2108
Onchocerca volvulus 0.0059 0.1605 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0868 0.1347
Giardia lamblia Cathepsin B precursor 0.0065 0.1844 0.5
Mycobacterium leprae conserved hypothetical protein 0.0041 0.0864 0.5
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1605 0.8189
Echinococcus granulosus cathepsin L 0.0033 0.0523 0.0682
Mycobacterium leprae Probable lipase LipE 0.0041 0.0864 0.5
Leishmania major cathepsin L-like protease 0.0059 0.1605 0.8437
Onchocerca volvulus Cathepsin L homolog 0.0059 0.1605 1
Loa Loa (eye worm) hypothetical protein 0.0059 0.1605 0.2492
Brugia malayi hypothetical protein 0.0041 0.0862 0.0896
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0864 0.2575
Brugia malayi Calcitonin receptor-like protein seb-1 0.0057 0.1516 0.1962
Brugia malayi Cathepsin L-like precursor 0.0059 0.1605 0.2108
Mycobacterium ulcerans hypothetical protein 0.0041 0.0864 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0864 0.134
Brugia malayi latrophilin 2 splice variant baaae 0.0039 0.0773 0.075
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0864 0.0898
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1605 0.8437
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.1979 0.2974
Echinococcus multilocularis cathepsin L cysteine protease 0.0059 0.1605 0.2385
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0059 0.1605 1
Brugia malayi cathepsin L-like precursor 0.0041 0.0868 0.0904
Schistosoma mansoni hypothetical protein 0.0041 0.0862 0.1216
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0864 0.1218
Plasmodium falciparum cysteine proteinase falcipain 3 0.0059 0.1605 1
Loa Loa (eye worm) transcription factor SMAD2 0.0136 0.479 0.7435
Loa Loa (eye worm) hypothetical protein 0.0041 0.0864 0.134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1605 0.8437
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1605 0.8189
Loa Loa (eye worm) hypothetical protein 0.0044 0.0975 0.1513
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0313 0.0486
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0059 0.1605 0.8189
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0041 0.0868 0.0904
Entamoeba histolytica hypothetical protein 0.0041 0.0862 0.3133
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0041 0.086 0.1212
Echinococcus granulosus cathepsin l1 0.0059 0.1605 0.2385
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1605 0.8437
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0041 0.0868 0.2606
Brugia malayi Cathepsin L-like cysteine proteinase 0.0041 0.0868 0.0904
Brugia malayi beta-lactamase family protein 0.0041 0.0864 0.0898
Trypanosoma cruzi cysteine peptidase, putative 0.0059 0.1605 0.2108
Loa Loa (eye worm) MH2 domain-containing protein 0.0136 0.479 0.7435
Loa Loa (eye worm) cytochrome P450 family protein 0.0028 0.0313 0.0486
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1605 0.8189
Toxoplasma gondii cathepsin B 0.0065 0.1844 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.0523 0.0682
Schistosoma mansoni cathepsin F (C01 family) 0.0041 0.0868 0.1224
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1605 0.8189
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1605 0.8189
Trypanosoma brucei hypothetical protein, conserved 0.0041 0.0864 0.3594
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.6442 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0868 0.1347
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1605 0.8189
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1605 0.8189
Echinococcus granulosus cathepsin l cysteine peptidase 0.0059 0.1605 0.2385
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0864 0.1218
Brugia malayi Cathepsin L-like precursor 0.0059 0.1605 0.2108
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0059 0.1605 0.2492
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0033 0.0523 0.0682
Brugia malayi Papain family cysteine protease containing protein 0.0033 0.0523 0.0343
Echinococcus multilocularis cysteine protease 0.0059 0.1605 0.2385
Leishmania major cathepsin L-like protease 0.0059 0.1605 0.8437
Leishmania major cathepsin L-like protease 0.0059 0.1605 0.8437
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0176 0.6442 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0057 0.1516 0.1962
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1605 0.8437
Loa Loa (eye worm) cathepsin B 0.0065 0.1844 0.2863
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.1605 1
Trypanosoma cruzi hypothetical protein, conserved 0.0041 0.0864 0.0898
Entamoeba histolytica cysteine proteinase, putative 0.0059 0.1605 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1605 0.8437
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0041 0.0864 1
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0065 0.1844 0.2498
Loa Loa (eye worm) hypothetical protein 0.008 0.2498 0.3878
Loa Loa (eye worm) fibroinase 0.0059 0.1605 0.2492
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0057 0.1516 0.2353
Loa Loa (eye worm) hypothetical protein 0.0041 0.0864 0.134
Trypanosoma cruzi cysteine proteinase, putative 0.0033 0.0523 0.0343
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0026 0.023 0.022
Echinococcus granulosus cathepsin b 0.0176 0.6442 1
Leishmania major cysteine peptidase A (CPA) 0.0059 0.1605 0.8437
Loa Loa (eye worm) hypothetical protein 0.0041 0.0864 0.134
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0176 0.6442 1
Trichomonas vaginalis D-aminoacylase, putative 0.0041 0.0864 0.2575
Mycobacterium ulcerans beta-lactamase 0.0041 0.0864 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0059 0.1605 0.2492
Echinococcus multilocularis cathepsin b 0.0176 0.6442 1
Trichomonas vaginalis esterase, putative 0.0041 0.0864 0.2575
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0864 0.0898
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0041 0.0862 0.1216
Brugia malayi Papain family cysteine protease containing protein 0.0059 0.1605 0.2108
Plasmodium vivax vivapain-2 0.0059 0.1605 1
Loa Loa (eye worm) ctsf protein 0.0059 0.1605 0.2492
Onchocerca volvulus 0.0041 0.0868 0.0054
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0065 0.1844 1
Onchocerca volvulus Cathepsin L homolog 0.0059 0.1605 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0864 0.134
Loa Loa (eye worm) cysteine protease 0.0059 0.1605 0.2492
Mycobacterium ulcerans lipase LipD 0.0041 0.0864 1
Brugia malayi beta-lactamase family protein 0.0041 0.0864 0.0898
Echinococcus granulosus cathepsin b 0.0176 0.6442 1
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0065 0.1844 1
Mycobacterium ulcerans esterase/lipase LipP 0.0041 0.0864 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0523 0.1372
Brugia malayi PHD-finger family protein 0.0028 0.0341 0.0045
Leishmania major cathepsin L-like protease 0.0059 0.1605 0.8437
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1605 0.8189
Trypanosoma cruzi cysteine protease, putative 0.0033 0.0523 0.0343
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0176 0.6442 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1605 0.8189
Brugia malayi Cathepsin L-like precursor 0.0059 0.1605 0.2108
Trypanosoma cruzi cysteine proteinase, putative 0.0033 0.0523 0.0343
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0059 0.1605 0.8189
Loa Loa (eye worm) beta-lactamase 0.0041 0.0864 0.134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1605 0.8437
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0059 0.1605 0.8437
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0059 0.1605 0.2385
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0033 0.0523 0.1372
Schistosoma mansoni bromodomain containing protein 0.0072 0.2148 0.324
Onchocerca volvulus Cathepsin F homolog 0.0059 0.1605 1
Leishmania major hypothetical protein, conserved 0.0041 0.0864 0.3594
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0864 0.1218
Onchocerca volvulus 0.0059 0.1605 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0059 0.1605 0.8189
Onchocerca volvulus 0.0059 0.1605 1
Echinococcus granulosus cathepsin L cysteine proteinase 0.0059 0.1605 0.2385
Echinococcus granulosus cysteine protease 0.0033 0.0523 0.0682
Trichomonas vaginalis penicillin-binding protein, putative 0.0041 0.0864 0.2575

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 4 Inhibition of human recombinant cathepsin L using Z-Phe-Arg-AMC as substrate preincubated for 30 mins measured after 1 hr by quenched fluorescent resonance energy transfer assay ChEMBL. 22858142
IC50 (binding) > 4 Inhibition of human ERG ChEMBL. 22858142
IC50 (ADMET) > 4.5 Inhibition of CYP1A2 ChEMBL. 22858142
IC50 (ADMET) = 5 Inhibition of CYP2C19 ChEMBL. 22858142
IC50 (binding) = 5.3 Inhibition of human recombinant cathepsin B using Z-Arg-Arg-AMC as substrate preincubated for 30 mins measured after 1 hr by quenched fluorescent resonance energy transfer assay ChEMBL. 22858142
IC50 (ADMET) = 5.4 Inhibition of CYP3A4 ChEMBL. 22858142
IC50 (binding) = 5.5 Inhibition of human recombinant cathepsin S using Z-Val-Val-Arg-AMC as substrate preincubated for 30 mins measured after 1 hr by quenched fluorescent resonance energy transfer assay ChEMBL. 22858142
IC50 (ADMET) = 5.5 Inhibition of CYP2C9 ChEMBL. 22858142
IC50 (ADMET) < 7 Inhibition of CYP2D6 ChEMBL. 22858142
IC50 (binding) = 7.4 Inhibition of human recombinant cathepsin K using Z-Phe-Arg-AMC as substrate preincubated for 30 mins measured after 1 hr by quenched fluorescent resonance energy transfer assay ChEMBL. 22858142

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.