Detailed information for compound 1670949

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 488.485 | Formula: C28H24O8
  • H donors: 2 H acceptors: 6 LogP: 2.36 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1)OC[C@@]1(O)C(=O)[C@H]2C=C[C@@H]1[C@H]1[C@@H]2C=CC(=O)[C@]1(O)COC(=O)c1ccccc1
  • InChi: 1S/C28H24O8/c29-22-14-12-19-20-11-13-21(23(19)28(22,34)16-36-26(32)18-9-5-2-6-10-18)27(33,24(20)30)15-35-25(31)17-7-3-1-4-8-17/h1-14,19-21,23,33-34H,15-16H2/t19-,20+,21-,23-,27+,28-/m1/s1
  • InChiKey: XXUFTPBMJHFXJE-MPGPANPZSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis polycomb protein SCMH1 0.0166 0.2901 0.3332
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.006 0.0863 0.0978
Loa Loa (eye worm) mbt repeat family protein 0.0173 0.303 0.582
Brugia malayi Shank2E 0.0016 0.0016 0.003
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0936 0.0935
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0286 0.5197 1
Brugia malayi plexin A 0.0063 0.0917 0.1765
Schistosoma mansoni zinc finger protein 0.0031 0.0309 0.0307
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0034 0.0366 0.0365
Loa Loa (eye worm) hypothetical protein 0.0286 0.5197 1
Schistosoma mansoni hypothetical protein 0.0072 0.1091 0.109
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0042 0.0041
Echinococcus multilocularis histone acetyltransferase MYST2 0.006 0.0863 0.0978
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0033 0.0351 0.0387
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0004
Plasmodium falciparum JmjC domain-containing protein, putative 0.0018 0.0062 0.3875
Brugia malayi Latrophilin receptor protein 2 0.0033 0.0351 0.0676
Echinococcus granulosus histone acetyltransferase myst3 0.0029 0.027 0.0294
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0033 0.0351 0.0387
Schistosoma mansoni bromodomain containing protein 0.0075 0.1153 0.1151
Brugia malayi hypothetical protein 0.0016 0.0016 0.003
Giardia lamblia Giardia trophozoite antigen GTA-1 0.0016 0.0016 0.5
Loa Loa (eye worm) hypothetical protein 0.0054 0.0758 0.1437
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0033 0.0345 0.3074
Schistosoma mansoni Protein aveugle 0.0016 0.0016 0.0014
Echinococcus multilocularis lysine specific demethylase 5A 0.0048 0.0643 0.0725
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0326 0.5966 0.6872
Loa Loa (eye worm) beta-lactamase 0.004 0.0474 0.0889
Brugia malayi CHD4 protein 0.002 0.0106 0.0204
Brugia malayi Calcitonin receptor-like protein seb-1 0.0105 0.1729 0.3327
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.006 0.0863 0.166
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.068 0.0767
Brugia malayi cask-interacting protein 2 0.0016 0.0016 0.003
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0474 0.3079
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0474 0.0472
Echinococcus granulosus histone acetyltransferase MYST2 0.006 0.0863 0.0978
Loa Loa (eye worm) tnks protein 0.0016 0.0016 0.0004
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0033 0.0345 0.2225
Schistosoma mansoni hypothetical protein 0.0015 0.0009 0.0007
Loa Loa (eye worm) latrophilin receptor protein 2 0.0033 0.0351 0.0651
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.068 0.0678
Brugia malayi mbt repeat family protein 0.0286 0.5197 1
Brugia malayi Bromodomain containing protein 0.0039 0.0453 0.0871
Loa Loa (eye worm) hypothetical protein 0.0105 0.1729 0.331
Loa Loa (eye worm) hypothetical protein 0.0022 0.0138 0.0241
Echinococcus multilocularis plexin a4 0.0063 0.0917 0.1041
Trypanosoma brucei SAM domain (Sterile alpha motif), putative 0.0016 0.0016 0.0047
Echinococcus granulosus plexin a4 0.0063 0.0917 0.1041
Toxoplasma gondii ABC1 family protein 0.004 0.0474 0.4296
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0936 0.0935
Brugia malayi Sema domain containing protein 0.0022 0.0138 0.0267
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0157 0.0984
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0474 0.4319
Schistosoma mansoni pyruvate dehydrogenase 0.0094 0.152 0.1519
Echinococcus multilocularis zinc finger protein 0.0031 0.0309 0.0339
Brugia malayi CXXC zinc finger family protein 0.0029 0.0268 0.0515
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0033 0.0351 0.0387
Schistosoma mansoni inositol monophosphatase 0.0071 0.1077 0.1076
Brugia malayi beta-lactamase 0.004 0.0474 0.0912
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.004 0.0474 0.0889
Schistosoma mansoni spingomyelin synthetase-related 0.0016 0.0016 0.0014
Leishmania major hypothetical protein, conserved 0.004 0.0474 0.3079
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0034 0.0366 0.0405
Brugia malayi beta-lactamase family protein 0.004 0.0474 0.0912
Toxoplasma gondii LsmAD domain-containing protein 0.0023 0.0157 0.1299
Loa Loa (eye worm) MBCTL1 0.006 0.0863 0.1638
Brugia malayi Inositol-1 0.0071 0.1077 0.2073
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0055 0.0053
Brugia malayi Bromodomain containing protein 0.0087 0.1379 0.2653
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0036 0.0407 0.0452
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0018 0.0055 0.0053
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0071 0.1077 0.7068
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0094 0.152 0.1738
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0809 0.7467
Loa Loa (eye worm) hypothetical protein 0.006 0.0863 0.1638
Echinococcus multilocularis geminin 0.017 0.2984 0.3429
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0036 0.0407 0.0452
Schistosoma mansoni phd finger protein 0.0029 0.027 0.0269
Brugia malayi hypothetical protein 0.0022 0.0138 0.0267
Echinococcus multilocularis inositol monophosphatase 1 0.0071 0.1077 0.1226
Loa Loa (eye worm) hypothetical protein 0.0022 0.0138 0.0241
Schistosoma mansoni inositol monophosphatase 0.0071 0.1077 0.1076
Onchocerca volvulus 0.004 0.0474 0.0885
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.068 0.0767
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.068 0.0767
Brugia malayi Sema domain containing protein 0.0022 0.0138 0.0267
Loa Loa (eye worm) hypothetical protein 0.0031 0.0306 0.0564
Loa Loa (eye worm) AIDA-1b 0.0016 0.0016 0.0004
Loa Loa (eye worm) hypothetical protein 0.0053 0.0731 0.1384
Onchocerca volvulus 0.0054 0.0758 0.1434
Schistosoma mansoni hypothetical protein 0.0022 0.0138 0.0137
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0758 0.0757
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0064 0.0934 0.1122
Leishmania major developmentally regulated phosphoprotein-like protein 0.0094 0.152 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0016 0.0018 0.0003
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0033 0.0345 0.2225
Giardia lamblia Kinesin-13 0.0016 0.0016 0.5
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0071 0.1077 1
Echinococcus granulosus semaphorin 5B 0.0022 0.0138 0.0142
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0004
Schistosoma mansoni hypothetical protein 0.0205 0.3638 0.3637
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0094 0.152 0.1738
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0071 0.1084 0.1233
Loa Loa (eye worm) hypothetical protein 0.0018 0.0055 0.0079
Echinococcus granulosus neuropeptide s receptor 0.0467 0.8674 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.004 0.0474 0.0529
Schistosoma mansoni Protein aveugle 0.0016 0.0016 0.0014
Loa Loa (eye worm) hypothetical protein 0.0022 0.0138 0.0241
Echinococcus multilocularis tumor suppressor p53 binding protein 1 0.0205 0.3638 0.4184
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.068 0.0678
Echinococcus multilocularis cpg binding protein 0.0042 0.0522 0.0585
Brugia malayi beta-lactamase family protein 0.004 0.0474 0.0912
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0004
Brugia malayi bicaudal-C 0.0016 0.0016 0.003
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0033 0.0351 0.0676
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0071 0.1077 1
Brugia malayi hypothetical protein 0.0023 0.0157 0.0303
Loa Loa (eye worm) hypothetical protein 0.004 0.0474 0.0889
Loa Loa (eye worm) hypothetical protein 0.004 0.0474 0.0889
Loa Loa (eye worm) jmjC domain-containing protein 0.0089 0.1425 0.2723
Plasmodium falciparum ataxin-2 like protein, putative 0.0023 0.0157 1
Schistosoma mansoni hypothetical protein 0.0033 0.0351 0.0349
Brugia malayi mbt repeat family protein 0.0173 0.303 0.5831
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0016 0.0018 0.0003
Echinococcus multilocularis tar DNA binding protein 0.0064 0.0936 0.1063
Trypanosoma brucei PAB1-binding protein , putative 0.0023 0.0157 0.0984
Echinococcus granulosus zinc finger protein 0.0031 0.0309 0.0339
Echinococcus granulosus GPCR family 2 0.0033 0.0351 0.0387
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0241 0.4329 0.4328
Schistosoma mansoni polyhomeotic 0.0016 0.0016 0.0014
Schistosoma mansoni cpg binding protein 0.0042 0.0522 0.0521
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0094 0.152 1
Schistosoma mansoni cpg binding protein 0.0029 0.0268 0.0266
Loa Loa (eye worm) hypothetical protein 0.0041 0.05 0.0938
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0326 0.5966 0.6872
Schistosoma mansoni hypothetical protein 0.0022 0.0138 0.0137
Echinococcus granulosus SAM and MBT domain containing protein 0.0241 0.4329 0.4982
Schistosoma mansoni hypothetical protein 0.0033 0.0351 0.0349
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0071 0.1077 0.7068
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0898 0.0896
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.1091 0.21
Brugia malayi RNA recognition motif domain containing protein 0.0064 0.0936 0.1801
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0038 0.0446 0.4025
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0936 0.0935
Plasmodium vivax protein kinase, putative 0.0018 0.0066 0.0084
Loa Loa (eye worm) hypothetical protein 0.004 0.0474 0.0889
Plasmodium falciparum ataxin-2 like protein, putative 0.0023 0.0157 1
Trypanosoma cruzi Kinesin-13 5, putative 0.0016 0.0016 0.0047
Loa Loa (eye worm) hypothetical protein 0.0054 0.0754 0.1429
Loa Loa (eye worm) hypothetical protein 0.004 0.0474 0.0889
Onchocerca volvulus 0.0053 0.0731 0.138
Brugia malayi Sphingomyelin synthase-related 1 0.0016 0.0016 0.003
Onchocerca volvulus 0.0022 0.0138 0.0237
Trypanosoma cruzi Kinesin-13 5, putative 0.0016 0.0016 0.0047
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0004
Toxoplasma gondii PLU-1 family protein 0.0027 0.024 0.2082
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.068 0.0678
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0071 0.1077 1
Brugia malayi TAR-binding protein 0.0064 0.0936 0.1801
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.002 0.0106 0.0104
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0936 0.0935
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0474 0.4319
Echinococcus multilocularis histone acetyltransferase myst3 0.0029 0.027 0.0294
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0033 0.0351 0.0387
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0014
Schistosoma mansoni hypothetical protein 0.0021 0.0112 0.011
Loa Loa (eye worm) inositol-1 0.0071 0.1077 0.2052
Plasmodium vivax hypothetical protein, conserved 0.004 0.0474 1
Schistosoma mansoni hypothetical protein 0.0031 0.0306 0.0304
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.006 0.0863 0.0978
Brugia malayi jmjC domain containing protein 0.0016 0.0018 0.0035
Schistosoma mansoni plexin 0.0053 0.0731 0.0729
Trichomonas vaginalis esterase, putative 0.004 0.0474 0.4319
Onchocerca volvulus 0.004 0.0474 0.0885
Schistosoma mansoni pyruvate dehydrogenase 0.0089 0.142 0.1418
Schistosoma mansoni tar DNA-binding protein 0.0064 0.0936 0.0935
Leishmania major hypothetical protein, conserved 0.0023 0.0157 0.0984
Echinococcus granulosus geminin 0.017 0.2984 0.3429
Loa Loa (eye worm) hypothetical protein 0.0071 0.1079 0.2055
Brugia malayi RNA binding protein 0.0064 0.0936 0.1801
Loa Loa (eye worm) sema domain-containing protein 0.0022 0.0138 0.0241
Echinococcus granulosus tar DNA binding protein 0.0064 0.0936 0.1063
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0268 0.049
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0253 0.4574 1
Schistosoma mansoni hypothetical protein 0.0412 0.7609 0.7609
Loa Loa (eye worm) hypothetical protein 0.0023 0.0157 0.0277
Echinococcus multilocularis semaphorin 5B 0.0022 0.0138 0.0142
Loa Loa (eye worm) hypothetical protein 0.0022 0.0138 0.0241
Brugia malayi jmjC domain containing protein 0.0089 0.1425 0.2742
Loa Loa (eye worm) hypothetical protein 0.0033 0.0351 0.0651
Loa Loa (eye worm) CHromoDomain protein family member 0.002 0.0106 0.0178
Echinococcus granulosus polycomb protein SCMH1 0.0166 0.2901 0.3332
Schistosoma mansoni myelin transcription factor 1 myt1 0.006 0.0863 0.0861
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.004 0.0474 0.0472
Schistosoma mansoni bromodomain containing protein 0.0016 0.0014 0.0012
Schistosoma mansoni pyruvate dehydrogenase 0.0089 0.142 0.1418
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0071 0.1077 1
Brugia malayi hypothetical protein 0.0022 0.0138 0.0267
Trypanosoma cruzi hypothetical protein 0.0016 0.0016 0.0047
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0105 0.1729 0.3327
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0004
Trichomonas vaginalis inositol monophosphatase, putative 0.0071 0.1077 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0889 0.0888
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0474 0.4319
Loa Loa (eye worm) TAR-binding protein 0.0064 0.0936 0.178
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0064 0.0934 1
Echinococcus multilocularis chromobox protein 2 0.0123 0.2077 0.2381
Echinococcus granulosus inositol monophosphatase 1 0.0071 0.1077 0.1226
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.068 0.1286
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0018 0.0055 0.0045
Echinococcus granulosus beta LACTamase domain containing family member 0.004 0.0474 0.0529
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0033 0.0345 0.2225
Loa Loa (eye worm) hypothetical protein 0.004 0.0474 0.0889
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0004
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0257 0.4654 0.8953
Schistosoma mansoni cpg binding protein 0.0042 0.0522 0.0521
Schistosoma mansoni hypothetical protein 0.0033 0.0351 0.0349
Loa Loa (eye worm) sema domain-containing protein 0.0022 0.0138 0.0241
Echinococcus granulosus histone lysine methyltransferase setb 0.0018 0.0055 0.0045
Echinococcus granulosus lysine specific demethylase 5A 0.0062 0.0898 0.1019
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0004
Schistosoma mansoni sex comb on midleg homolog 0.0166 0.2901 0.2899
Echinococcus granulosus methyl CpG binding domain protein 2 0.0017 0.0042 0.0031
Echinococcus multilocularis hypothetical protein 0.0022 0.0138 0.0142
Schistosoma mansoni hypothetical protein 0.017 0.2984 0.2983
Echinococcus granulosus fetal alzheimer antigen falz 0.0034 0.0366 0.0405
Loa Loa (eye worm) plexin A 0.0063 0.0917 0.1743
Echinococcus multilocularis GPCR, family 2 0.0033 0.0351 0.0387
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0071 0.1077 0.5
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.004 0.0474 0.0912
Echinococcus multilocularis SAM and MBT domain containing protein 0.0241 0.4329 0.4982
Loa Loa (eye worm) hypothetical protein 0.0022 0.0138 0.0241
Schistosoma mansoni hypothetical protein 0.0016 0.0016 0.0014
Brugia malayi kinase, mitochondrial precursor 0.0094 0.152 0.2926
Loa Loa (eye worm) hypothetical protein 0.0039 0.0454 0.085
Loa Loa (eye worm) hypothetical protein 0.0016 0.0016 0.0004
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0075 0.115 0.1311
Schistosoma mansoni zinc finger protein 0.0015 0.0009 0.0007
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0071 0.1077 0.7068
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0105 0.1729 0.331
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0094 0.152 0.1738
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0157 0.0984
Echinococcus granulosus tumor suppressor p53 binding protein 1 0.0205 0.3638 0.4184
Onchocerca volvulus 0.004 0.0474 0.0885
Brugia malayi Liprin-alpha 2 0.0016 0.0016 0.003
Echinococcus multilocularis dnaJ subfamily B 0.0412 0.7609 0.8771
Loa Loa (eye worm) hypothetical protein 0.0022 0.0138 0.0241
Schistosoma mansoni chromodomain helicase DNA binding protein 0.002 0.0106 0.0104
Trichomonas vaginalis D-aminoacylase, putative 0.004 0.0474 0.4319
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.068 0.0767
Loa Loa (eye worm) hypothetical protein 0.0072 0.1091 0.2079
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0071 0.1084 0.1233
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0075 0.115 0.1311
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0106 0.0203
Echinococcus granulosus semaphorin 1A 0.0022 0.0138 0.0142
Schistosoma mansoni hypothetical protein 0.0033 0.0351 0.0349
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0017 0.0042 0.0031
Schistosoma mansoni plexin 0.0031 0.0306 0.0304
Schistosoma mansoni lip-related protein (liprin) alpha 0.0016 0.0016 0.0014
Loa Loa (eye worm) toll and interleukin 1 receptor domain-containing protein isoform f 0.0016 0.0016 0.0004
Schistosoma mansoni DNAj-like protein 0.0016 0.0016 0.0014
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.005 0.068 0.1308
Brugia malayi Plexin repeat family protein 0.0053 0.0731 0.1406
Brugia malayi PHD-finger family protein 0.0036 0.0412 0.0793
Plasmodium vivax ataxin-2 like protein, putative 0.0023 0.0157 0.2314
Brugia malayi sterile alpha and TIR motif containing protein 1 isoform a 0.0016 0.0016 0.003
Brugia malayi hypothetical protein 0.0016 0.0016 0.003
Trypanosoma brucei hypothetical protein, conserved 0.004 0.0474 0.3079
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0064 0.0936 0.178
Schistosoma mansoni methyl-cpg binding protein mbd 0.0017 0.0042 0.0041
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0071 0.1077 1
Schistosoma mansoni jumonji domain containing protein 0.0016 0.0018 0.0016
Schistosoma mansoni hypothetical protein 0.017 0.2984 0.2983
Trypanosoma cruzi hypothetical protein, conserved 0.004 0.0474 0.3079
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0112 0.0189
Echinococcus granulosus dnaJ subfamily B 0.0412 0.7609 0.8771
Schistosoma mansoni chromobox protein 0.0123 0.2077 0.2076
Loa Loa (eye worm) hypothetical protein 0.0094 0.152 0.2907
Loa Loa (eye worm) RNA binding protein 0.0064 0.0936 0.178
Schistosoma mansoni semaphorin 5-related 0.0022 0.0138 0.0137
Trichomonas vaginalis penicillin-binding protein, putative 0.004 0.0474 0.4319
Schistosoma mansoni sex comb on midleg homolog 0.0166 0.2901 0.2899
Echinococcus granulosus chromobox protein 2 0.0123 0.2077 0.2381
Onchocerca volvulus 0.0189 0.3332 0.6402
Echinococcus multilocularis neuropeptide receptor A26 0.0467 0.8674 1
Trypanosoma brucei developmentally regulated phosphoprotein 0.0094 0.152 1
Echinococcus granulosus neuropeptide receptor A26 0.0467 0.8674 1
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0054 0.0078
Echinococcus granulosus tumor protein p63 0.0372 0.6854 0.7898
Echinococcus multilocularis neuropeptide s receptor 0.0467 0.8674 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0071 0.1077 0.7068
Trypanosoma brucei Present in the outer mitochondrial membrane proteome 24 0.0016 0.0016 0.0047
Onchocerca volvulus 0.0029 0.0268 0.0486
Schistosoma mansoni lar interacting protein (lip)-related protein 0.0016 0.0016 0.0014
Echinococcus granulosus cpg binding protein 0.0042 0.0522 0.0585
Brugia malayi AIDA-1b 0.0016 0.0016 0.003
Brugia malayi coiled-coil like protein 1 0.0016 0.0016 0.003
Echinococcus multilocularis tumor protein p63 0.0372 0.6854 0.7898
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.002 0.0106 0.0104
Schistosoma mansoni jumonji/arid domain-containing protein 0.0062 0.0898 0.0896
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.002 0.0101 0.0769
Loa Loa (eye worm) hypothetical protein 0.004 0.0474 0.0889
Brugia malayi follicle stimulating hormone receptor 0.0257 0.4654 0.8955

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) > 500 uM Anti-austerity antiproliferative activity against nutrient-deprived human HT-29 cells after 72 hrs in presence of 0.5% serum ChEMBL. 24835628
PC50 (functional) = 14.5 uM Cytotoxicity against human PANC1 cells grown in nutrient-deprived medium after 24 hrs by WST8 assay ChEMBL. 22676269

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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