Detailed information for compound 167968

Basic information

Technical information
  • TDR Targets ID: 167968
  • Name: 2-[[3-[[2-[4-[(2-methylphenyl)carbamoylamino] phenyl]acetyl]amino]phenyl]carbamoylamino]ace tic acid
  • MW: 475.497 | Formula: C25H25N5O5
  • H donors: 6 H acceptors: 5 LogP: 2.22 Rotable bonds: 13
    Rule of 5 violations (Lipinski): 2
  • SMILES: O=C(Nc1cccc(c1)NC(=O)NCC(=O)O)Cc1ccc(cc1)NC(=O)Nc1ccccc1C
  • InChi: 1S/C25H25N5O5/c1-16-5-2-3-8-21(16)30-25(35)28-18-11-9-17(10-12-18)13-22(31)27-19-6-4-7-20(14-19)29-24(34)26-15-23(32)33/h2-12,14H,13,15H2,1H3,(H,27,31)(H,32,33)(H2,26,29,34)(H2,28,30,35)
  • InChiKey: PABDFJGYMMQDCU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[3-[[2-[4-(o-tolylcarbamoylamino)phenyl]acetyl]amino]phenyl]carbamoylamino]acetic acid
  • 2-[[[3-[[2-[4-[[(2-methylanilino)-oxomethyl]amino]phenyl]-1-oxoethyl]amino]anilino]-oxomethyl]amino]acetic acid
  • 2-[[3-[2-[4-[(2-methylphenyl)carbamoylamino]phenyl]ethanoylamino]phenyl]carbamoylamino]ethanoic acid
  • 2-[[[[3-[[2-[4-[[[(2-methylphenyl)amino]-oxomethyl]amino]phenyl]-1-oxoethyl]amino]phenyl]amino]-oxomethyl]amino]acetic acid

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Loa Loa (eye worm) integrin beta-2 Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma mansoni integrin beta subunit Get druggable targets OG5_127959 All targets in OG5_127959
Echinococcus multilocularis integrin beta 2 Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma japonicum ko:K06464 integrin beta 2, putative Get druggable targets OG5_127959 All targets in OG5_127959
Brugia malayi Integrin beta pat-3 precursor Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma japonicum Integrin beta-3 precursor, putative Get druggable targets OG5_127959 All targets in OG5_127959
Schistosoma japonicum Integrin beta-PS precursor, putative Get druggable targets OG5_127959 All targets in OG5_127959
Echinococcus granulosus integrin beta 2 Get druggable targets OG5_127959 All targets in OG5_127959
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) papain family cysteine protease containing protein 0.003 0.0149 0.0266
Onchocerca volvulus 0.0078 0.0813 0.6087
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.1336 0.718
Echinococcus granulosus cathepsin L cysteine proteinase 0.0078 0.0813 0.1453
Brugia malayi follicle stimulating hormone receptor 0.028 0.3646 0.6516
Trypanosoma cruzi cysteine proteinase, putative 0.003 0.0149 0.0232
Entamoeba histolytica cysteine protease, putative 0.003 0.0149 0.1095
Leishmania major cathepsin L-like protease 0.0078 0.0813 0.192
Onchocerca volvulus Cathepsin L homolog 0.0078 0.0813 0.6087
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.003 0.0149 0.0643
Mycobacterium leprae Probable lipase LipE 0.0115 0.1336 0.1757
Echinococcus multilocularis geminin 0.0335 0.4402 0.7867
Brugia malayi hypothetical protein 0.0057 0.0531 0.0948
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.2358 0.2945
Entamoeba histolytica cysteine protease, putative 0.003 0.0149 0.1095
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.003 0.0149 0.0186
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0117 0.1356 0.2423
Entamoeba histolytica cysteine protease, putative 0.003 0.0149 0.1095
Echinococcus multilocularis integrin beta 2 0.028 0.3642 0.6509
Trypanosoma brucei trypanothione reductase 0.0185 0.2319 1
Trypanosoma brucei Aminopeptidase M1, putative 0.0035 0.022 0.0676
Entamoeba histolytica cysteine protease, putative 0.003 0.0149 0.1095
Loa Loa (eye worm) hypothetical protein 0.0069 0.0694 0.1241
Schistosoma mansoni cathepsin C 0.003 0.0149 0.0186
Entamoeba histolytica aminopeptidase, putative 0.0035 0.022 0.2042
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0149 0.0462
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.003 0.0149 0.0643
Loa Loa (eye worm) hypothetical protein 0.0078 0.0813 0.1453
Mycobacterium tuberculosis Probable lipase LipD 0.0115 0.1336 0.1088
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0188 0.2358 0.4214
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0078 0.0813 0.1453
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0626 0.1087
Mycobacterium ulcerans aldehyde dehydrogenase 0.0256 0.331 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0115 0.1336 0.718
Leishmania major cysteine peptidase A (CPA) 0.0078 0.0813 0.192
Brugia malayi cathepsin B-like cysteine proteinase 0.042 0.5596 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0149 0.0462
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0342 0.0579
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0115 0.1336 0.3611
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0064 0.0626 0.1118
Plasmodium falciparum serine repeat antigen 4 0.003 0.0149 0.0643
Echinococcus granulosus inositol monophosphatase 1 0.0044 0.0342 0.0612
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0423 0.5638 0.8904
Loa Loa (eye worm) integrin beta-2 0.0378 0.5012 0.8956
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0149 0.0462
Onchocerca volvulus 0.0078 0.0813 0.6087
Echinococcus multilocularis cathepsin b 0.042 0.5596 1
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.1336 0.236
Echinococcus multilocularis cathepsin L cysteine protease 0.0078 0.0813 0.1453
Entamoeba histolytica cysteine protease, putative 0.003 0.0149 0.1095
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0813 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0813 0.4221
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0256 0.331 0.5915
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0064 0.0626 0.0782
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0149 0.0462
Schistosoma mansoni inositol monophosphatase 0.0044 0.0342 0.0428
Entamoeba histolytica papain family cysteine protease domain containing protein 0.003 0.0149 0.1095
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0064 0.0626 0.1314
Brugia malayi STAT protein, DNA binding domain containing protein 0.013 0.1543 0.2758
Schistosoma mansoni lipoxygenase 0.0117 0.1356 0.1693
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0043 0.0329 0.0589
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0342 0.0398
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0149 0.0462
Plasmodium vivax thioredoxin reductase, putative 0.0185 0.2319 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.003 0.0149 0.0363
Leishmania major cathepsin L-like protease 0.0078 0.0813 0.192
Onchocerca volvulus 0.0035 0.022 0.1644
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.042 0.5596 1
Giardia lamblia Cathepsin B precursor 0.0151 0.1834 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0115 0.1336 0.1668
Entamoeba histolytica cysteine proteinase 2 0.003 0.0149 0.1095
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.003 0.0149 0.0643
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.003 0.0149 0.0643
Entamoeba histolytica cysteine protease, putative 0.003 0.0149 0.1095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0813 0.3312
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.003 0.0149 0.0186
Leishmania major cathepsin L-like protease 0.0078 0.0813 0.192
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0064 0.0626 0.2698
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0115 0.1336 0.1668
Loa Loa (eye worm) STAT protein 0.013 0.1543 0.2758
Onchocerca volvulus Cathepsin L homolog 0.0078 0.0813 0.6087
Echinococcus granulosus cysteine protease 0.003 0.0149 0.0266
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.003 0.0149 0.0232
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0813 0.4221
Loa Loa (eye worm) aminopeptidase N 0.0035 0.022 0.0392
Brugia malayi Papain family cysteine protease containing protein 0.003 0.0149 0.0266
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0047 0.0387 0.0692
Entamoeba histolytica cysteine proteinase 1, putative 0.003 0.0149 0.1095
Plasmodium falciparum glutathione reductase 0.0064 0.0626 0.2698
Trypanosoma cruzi aminopeptidase, putative 0.0035 0.022 0.0358
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0813 0.4221
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.003 0.0149 0.0186
Echinococcus granulosus aminopeptidase N 0.0035 0.022 0.0392
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.003 0.0149 0.0462
Schistosoma mansoni hypothetical protein 0.0335 0.4402 0.5498
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0188 0.2358 0.4214
Schistosoma mansoni cathepsin S (C01 family) 0.003 0.0149 0.0186
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0115 0.1336 0.1088
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.047 0.6298 0.6192
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.022 0.0392
Loa Loa (eye worm) hypothetical protein 0.0023 0.0047 0.0083
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0043 0.0329 0.3515
Trypanosoma cruzi cysteine proteinase, putative 0.003 0.0149 0.0232
Loa Loa (eye worm) hypothetical protein 0.0023 0.0047 0.0083
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0043 0.0329 0.0808
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0064 0.0626 0.1314
Loa Loa (eye worm) hypothetical protein 0.0023 0.0047 0.0083
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.003 0.0149 0.0186
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0022 0.0036 0.0045
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0813 0.3312
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.0342 0.1557
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.003 0.0149 0.0462
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0064 0.0626 0.1087
Plasmodium falciparum cysteine proteinase falcipain 3 0.0078 0.0813 0.3506
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0078 0.0813 0.3506
Plasmodium falciparum serine repeat antigen 3 0.003 0.0149 0.0643
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0185 0.2319 0.2099
Plasmodium falciparum serine repeat antigen 9 0.003 0.0149 0.0643
Onchocerca volvulus 0.0115 0.1336 1
Entamoeba histolytica cysteine protease, putative 0.003 0.0149 0.1095
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0044 0.0342 0.0848
Schistosoma mansoni alpha glucosidase 0.0043 0.0329 0.0411
Schistosoma mansoni integrin beta subunit 0.0223 0.284 0.3546
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.1336 0.718
Schistosoma mansoni aldehyde dehydrogenase 0.0256 0.331 0.4134
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0188 0.2358 0.4214
Loa Loa (eye worm) hypothetical protein 0.0115 0.1336 0.2387
Onchocerca volvulus Cathepsin F homolog 0.0078 0.0813 0.6087
Trypanosoma cruzi trypanothione reductase, putative 0.0064 0.0626 0.1087
Onchocerca volvulus 0.0078 0.0813 0.6087
Trypanosoma brucei cysteine peptidase C (CPC) 0.0151 0.1834 0.7845
Loa Loa (eye worm) hypothetical protein 0.0115 0.1336 0.2387
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0813 0.1422
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0035 0.022 0.0676
Toxoplasma gondii cathepsin CPL 0.0078 0.0813 0.2299
Loa Loa (eye worm) cathepsin B 0.0151 0.1834 0.3277
Schistosoma mansoni bromodomain containing protein 0.0062 0.0593 0.074
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.1336 0.236
Plasmodium falciparum serine repeat antigen 6 0.003 0.0149 0.0643
Trypanosoma brucei Aminopeptidase M1, putative 0.0035 0.022 0.0676
Onchocerca volvulus 0.0078 0.0813 0.6087
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.003 0.0149 0.0266
Loa Loa (eye worm) inositol-1 0.0044 0.0342 0.0612
Leishmania major cathepsin L-like protease 0.0078 0.0813 0.192
Echinococcus granulosus integrin beta 2 0.028 0.3642 0.6509
Loa Loa (eye worm) hypothetical protein 0.0021 0.002 0.0035
Brugia malayi Bromodomain containing protein 0.0073 0.0753 0.1345
Entamoeba histolytica cysteine protease, putative 0.003 0.0149 0.1095
Onchocerca volvulus 0.0078 0.0813 0.6087
Mycobacterium ulcerans aldehyde dehydrogenase 0.0256 0.331 1
Loa Loa (eye worm) hypothetical protein 0.0115 0.1336 0.2387
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0149 0.0462
Leishmania major cathepsin L-like protease 0.0078 0.0813 0.192
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0064 0.0626 0.248
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0022 0.0036 0.0064
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0188 0.2358 0.4214
Loa Loa (eye worm) papain family cysteine protease containing protein 0.003 0.0149 0.0266
Toxoplasma gondii thioredoxin reductase 0.0185 0.2319 0.6943
Plasmodium vivax serine-repeat antigen (SERA), putative 0.003 0.0149 0.0643
Echinococcus multilocularis aminopeptidase N 0.0035 0.022 0.0392
Loa Loa (eye worm) hypothetical protein 0.003 0.0149 0.0266
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0043 0.0329 0.3515
Plasmodium vivax vivapain-2 0.0078 0.0813 0.3506
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0149 0.0462
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0813 0.4221
Mycobacterium tuberculosis Probable esterase LipL 0.0115 0.1336 0.1088
Echinococcus granulosus cathepsin L 0.003 0.0149 0.0266
Toxoplasma gondii NADPH-glutathione reductase 0.0064 0.0626 0.1722
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0064 0.0626 0.1314
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0813 0.4221
Brugia malayi Papain family cysteine protease containing protein 0.003 0.0149 0.0266
Trypanosoma cruzi major cysteine proteinase, putative 0.003 0.0149 0.0232
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.003 0.0149 0.0462
Loa Loa (eye worm) hypothetical protein 0.003 0.0149 0.0266
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0151 0.1834 0.229
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0151 0.1834 1
Trypanosoma cruzi cysteine protease, putative 0.003 0.0149 0.0232
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.003 0.0149 0.0462
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0813 0.3312
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0044 0.0342 0.0398
Onchocerca volvulus 0.0078 0.0813 0.6087
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0151 0.1834 0.5223
Loa Loa (eye worm) PHD-finger family protein 0.002 0.001 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0188 0.2358 0.4214
Echinococcus multilocularis cathepsin L 0.003 0.0149 0.0266
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0149 0.1095
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0078 0.0813 0.4221
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0078 0.0813 0.1422
Plasmodium vivax serine-repeat antigen (SERA), putative 0.003 0.0149 0.0643
Plasmodium falciparum serine repeat antigen 2 0.003 0.0149 0.0643
Trypanosoma cruzi major cysteine proteinase, putative 0.003 0.0149 0.0232
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.003 0.0149 0.0186
Brugia malayi cathepsin F-like cysteine proteinase 0.003 0.0149 0.0266
Echinococcus multilocularis beta LACTamase domain containing family member 0.0115 0.1336 0.2387
Schistosoma mansoni alpha-glucosidase 0.0167 0.2061 0.2575
Brugia malayi Cathepsin L-like cysteine proteinase 0.0078 0.0813 0.1453
Leishmania major trypanothione reductase 0.0185 0.2319 0.6793
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0329 0.1484
Loa Loa (eye worm) cytochrome P450 family protein 0.0048 0.0401 0.0717
Loa Loa (eye worm) ctsf protein 0.0078 0.0813 0.1453
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.042 0.5596 0.6989
Mycobacterium tuberculosis Probable lipase LipE 0.0115 0.1336 0.1088
Giardia lamblia Cathepsin B precursor 0.0151 0.1834 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0813 0.3312
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0023 0.0047 0.0048
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0188 0.2358 0.4214
Toxoplasma gondii cathepsin B 0.0151 0.1834 0.5447
Echinococcus granulosus lysosomal alpha glucosidase 0.0194 0.2439 0.4358
Entamoeba histolytica cysteine protease, putative 0.003 0.0149 0.1095
Plasmodium vivax hypothetical protein, conserved 0.0115 0.1336 0.576
Plasmodium falciparum glutathione reductase 0.0185 0.2319 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0626 0.1087
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0813 0.4221
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.003 0.0149 0.0462
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0813 0.3312
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.1336 0.718
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0256 0.331 0.3119
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0064 0.0626 0.1722
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0067 0.012
Toxoplasma gondii cathepsin CPC1 0.003 0.0149 0.0252
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0423 0.5638 0.5514
Entamoeba histolytica hypothetical protein 0.003 0.0149 0.1095
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.042 0.5596 0.6989
Brugia malayi Papain family cysteine protease containing protein 0.003 0.0149 0.0266
Mycobacterium ulcerans beta-lactamase 0.0115 0.1336 0.3611
Brugia malayi glutathione reductase 0.0185 0.2319 0.4144
Entamoeba histolytica cysteine protease, putative 0.003 0.0149 0.1095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0813 0.3312
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0067 0.012
Entamoeba histolytica cysteine protease, putative 0.0078 0.0813 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0187 0.2334 0.4171
Schistosoma mansoni cathepsin B (C01 family) 0.003 0.0149 0.0186
Mycobacterium tuberculosis Probable reductase 0.0423 0.5638 0.5514
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0813 0.1422
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0035 0.022 0.0274
Schistosoma mansoni inositol monophosphatase 0.0044 0.0342 0.0428
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0115 0.1336 0.1088
Mycobacterium ulcerans lipase LipD 0.0115 0.1336 0.3611
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0064 0.0626 0.1314
Echinococcus granulosus thioredoxin glutathione reductase 0.0187 0.2334 0.4171
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0813 0.4221
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0813 0.4221
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0067 0.012
Echinococcus granulosus fetal alzheimer antigen falz 0.0022 0.0036 0.0064
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0813 0.4221
Brugia malayi Cathepsin L-like precursor 0.0078 0.0813 0.1453
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0023 0.0047 0.0083
Echinococcus granulosus cathepsin b 0.042 0.5596 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.2358 0.2945
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0329 0.1484
Plasmodium vivax serine-repeat antigen (SERA) 0.003 0.0149 0.0643
Plasmodium vivax vivapain-3 0.003 0.0149 0.0643
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.003 0.0149 0.0186
Loa Loa (eye worm) hypothetical protein 0.0115 0.1336 0.2387
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0813 0.3312
Loa Loa (eye worm) hypothetical protein 0.0038 0.0252 0.0451
Brugia malayi beta-lactamase 0.0115 0.1336 0.2387
Giardia lamblia Cathepsin B precursor 0.0151 0.1834 1
Schistosoma mansoni alpha-glucosidase 0.0167 0.2061 0.2575
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0078 0.0813 0.4221
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0813 0.4221
Echinococcus multilocularis inositol monophosphatase 1 0.0044 0.0342 0.0612
Onchocerca volvulus 0.0078 0.0813 0.6087
Loa Loa (eye worm) hypothetical protein 0.042 0.5596 1
Plasmodium falciparum cysteine proteinase falcipain 1 0.003 0.0149 0.0643
Leishmania major cathepsin L-like protease 0.0078 0.0813 0.192
Brugia malayi Cathepsin L-like precursor 0.0078 0.0813 0.1453
Echinococcus granulosus cathepsin L cysteine protease 0.003 0.0149 0.0266
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.003 0.0149 0.0643
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.003 0.0149 0.0186
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0044 0.0342 0.3689
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.003 0.0149 0.0643
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0035 0.022 0.0862
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.003 0.0149 0.0363
Mycobacterium ulcerans hypothetical protein 0.0115 0.1336 0.3611
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0219 0.0391
Echinococcus multilocularis neutral alpha glucosidase AB 0.0043 0.0329 0.0589
Brugia malayi Cathepsin L-like precursor 0.0078 0.0813 0.1453
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0064 0.0626 0.0358
Trypanosoma cruzi Aminopeptidase M1, putative 0.0035 0.022 0.0358
Entamoeba histolytica cysteine protease, putative 0.003 0.0149 0.1095
Trichomonas vaginalis inositol monophosphatase, putative 0.0044 0.0342 0.1557
Brugia malayi Peptidase family M1 containing protein 0.0035 0.022 0.0392
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0149 0.0462
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.003 0.0149 0.0643
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0813 0.4221
Schistosoma mansoni cathepsin F (C01 family) 0.0078 0.0813 0.1015
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.022 0.0392
Trypanosoma brucei glucosidase, putative 0.0043 0.0329 0.1164
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0064 0.0626 0.2698
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.003 0.0149 0.0462
Echinococcus granulosus cathepsin l1 0.0078 0.0813 0.1453
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0813 0.3312
Echinococcus multilocularis cysteine protease 0.0078 0.0813 0.1453
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0342 0.0579
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.042 0.5596 0.6989
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0194 0.2439 0.4358
Echinococcus granulosus geminin 0.0335 0.4402 0.7867
Mycobacterium tuberculosis Conserved protein 0.0115 0.1336 0.1088
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0047 0.0387 0.0692
Loa Loa (eye worm) hypothetical protein 0.0115 0.1336 0.2387
Brugia malayi Papain family cysteine protease containing protein 0.003 0.0149 0.0266
Entamoeba histolytica cysteine protease, putative 0.003 0.0149 0.1095
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.047 0.6298 1
Plasmodium falciparum serine repeat antigen 7 0.003 0.0149 0.0643
Brugia malayi Cathepsin L-like precursor 0.0078 0.0813 0.1453
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0813 0.4221
Echinococcus multilocularis cysteine protease 0.0078 0.0813 0.1453
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0064 0.0626 0.1118
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0035 0.022 0.0392
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.003 0.0149 0.0186
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.022 0.0392
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0813 0.4221
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0149 0.0462
Loa Loa (eye worm) beta-lactamase 0.0115 0.1336 0.2387
Loa Loa (eye worm) hypothetical protein 0.0057 0.0531 0.0948
Brugia malayi cahepsin L-like non-peptiedase homolog 0.003 0.0149 0.0266
Toxoplasma gondii cathepsin CPC2 0.003 0.0149 0.0252
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0813 1
Leishmania major hypothetical protein, conserved 0.0115 0.1336 0.3611
Trichomonas vaginalis maltase-glucoamylase, putative 0.0043 0.0329 0.1484
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0115 0.1336 0.1088
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0626 0.1087
Brugia malayi cathepsin Z-like cysteine proteinase 0.003 0.0149 0.0266
Echinococcus multilocularis lysosomal alpha glucosidase 0.0194 0.2439 0.4358
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.003 0.0149 0.0643
Leishmania major cathepsin L-like protease 0.0078 0.0813 0.192
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.003 0.0149 0.0462
Onchocerca volvulus 0.0112 0.1296 0.9702
Loa Loa (eye worm) hypothetical protein 0.003 0.0149 0.0266
Trichomonas vaginalis esterase, putative 0.0115 0.1336 0.718
Loa Loa (eye worm) hypothetical protein 0.0078 0.0813 0.1453
Brugia malayi Papain family cysteine protease containing protein 0.003 0.0149 0.0266
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0044 0.0342 0.1222
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.003 0.0149 0.0643
Plasmodium falciparum serine repeat antigen 8 0.003 0.0149 0.0643
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.022 0.0392
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.003 0.0149 0.0186
Leishmania major cathepsin L-like protease 0.0078 0.0813 0.192
Schistosoma mansoni hypothetical protein 0.002 0.001 0.0012
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0149 0.1095
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0064 0.0626 0.1314
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0813 0.3312
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0813 0.4221
Schistosoma mansoni cathepsin F (C01 family) 0.0078 0.0813 0.1015
Echinococcus granulosus neutral alpha glucosidase AB 0.0043 0.0329 0.0589
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0813 0.4221
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.022 0.0392
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.003 0.0149 0.0643
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0329 0.0555
Brugia malayi hypothetical protein 0.0035 0.022 0.0392
Trypanosoma cruzi trypanothione reductase, putative 0.0185 0.2319 0.4123
Entamoeba histolytica papain family cysteine protease domain containing protein 0.003 0.0149 0.1095
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0813 0.4221
Trypanosoma cruzi cysteine peptidase, putative 0.003 0.0149 0.0232
Brugia malayi Integrin beta pat-3 precursor 0.0378 0.5012 0.8956
Leishmania major alpha glucosidase II subunit, putative 0.0043 0.0329 0.0355
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0219 0.0391
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0813 0.4221
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0117 0.1356 0.2423
Mycobacterium tuberculosis Probable dehydrogenase 0.0423 0.5638 0.5514
Onchocerca volvulus Cathepsin L homolog 0.003 0.0149 0.1116
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0064 0.0626 0.1087
Mycobacterium tuberculosis Conserved protein 0.0115 0.1336 0.1088
Brugia malayi Cathepsin L-like precursor 0.0078 0.0813 0.1453
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0256 0.331 1
Toxoplasma gondii ABC1 family protein 0.0115 0.1336 0.3911
Schistosoma mansoni cathepsin F (C01 family) 0.0078 0.0813 0.1015
Entamoeba histolytica cysteine protease, putative 0.003 0.0149 0.1095
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0043 0.0329 0.1484
Loa Loa (eye worm) hypothetical protein 0.0042 0.0311 0.0555
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0035 0.022 0.0358
Plasmodium falciparum serine repeat antigen 5 0.003 0.0149 0.0643
Brugia malayi fibroinase precursor 0.003 0.0149 0.0266
Brugia malayi PHD-finger family protein 0.0024 0.0068 0.0122
Toxoplasma gondii aldehyde dehydrogenase 0.0256 0.331 1
Plasmodium vivax unspecified product 0.003 0.0149 0.0643
Onchocerca volvulus 0.003 0.0149 0.1116
Onchocerca volvulus 0.0078 0.0813 0.6087
Brugia malayi cathepsin Z-like cysteine proteinase 0.003 0.0149 0.0266
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0064 0.0626 0.5
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0035 0.022 0.0862
Plasmodium falciparum thioredoxin reductase 0.0064 0.0626 0.2698
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0626 0.1087
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0044 0.0342 0.1557
Trichomonas vaginalis glutathione reductase, putative 0.0064 0.0626 0.3161
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0058 0.0544 0.0972
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0149 0.1095
Echinococcus multilocularis lysosomal alpha glucosidase 0.0194 0.2439 0.4358
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0064 0.0626 0.1314
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0149 0.0462
Echinococcus granulosus beta LACTamase domain containing family member 0.0115 0.1336 0.2387
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0256 0.331 0.5915
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0064 0.0626 0.1314
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0078 0.0813 0.1453
Plasmodium vivax glutathione reductase, putative 0.0185 0.2319 1
Onchocerca volvulus 0.0115 0.1336 1
Brugia malayi Glycosyl hydrolases family 31 protein 0.0194 0.2439 0.4358
Loa Loa (eye worm) thioredoxin reductase 0.0185 0.2319 0.4144
Mycobacterium tuberculosis Conserved protein 0.0115 0.1336 0.1088
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.003 0.0149 0.0643
Brugia malayi beta-lactamase family protein 0.0115 0.1336 0.2387
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0149 0.1095
Brugia malayi Peptidase family M1 containing protein 0.0035 0.022 0.0392
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0626 0.1087
Loa Loa (eye worm) hypothetical protein 0.0078 0.0813 0.1453
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0064 0.0626 0.1087
Onchocerca volvulus 0.0035 0.022 0.1644
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0149 0.0462
Loa Loa (eye worm) glutathione reductase 0.0185 0.2319 0.4144
Brugia malayi Cytochrome P450 family protein 0.0048 0.0401 0.0717
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0064 0.0626 0.2698
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.022 0.0392
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0078 0.0813 0.1453
Plasmodium falciparum serine repeat antigen 1 0.003 0.0149 0.0643
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0115 0.1336 0.2387
Mycobacterium leprae conserved hypothetical protein 0.0115 0.1336 0.1757
Plasmodium vivax serine-repeat antigen (SERA) 0.003 0.0149 0.0643
Mycobacterium ulcerans aldehyde dehydrogenase 0.0256 0.331 1
Echinococcus granulosus cathepsin b 0.042 0.5596 1
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0067 0.0084
Plasmodium vivax unspecified product 0.003 0.0149 0.0643
Loa Loa (eye worm) hypothetical protein 0.0115 0.1336 0.2387
Brugia malayi beta-lactamase family protein 0.0115 0.1336 0.2387
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0813 0.4221
Brugia malayi Cathepsin L-like precursor 0.0078 0.0813 0.1453
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0078 0.0813 0.1453
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0064 0.0626 1
Entamoeba histolytica cysteine protease, putative 0.003 0.0149 0.1095
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.003 0.0149 0.0186
Loa Loa (eye worm) fibroinase 0.0078 0.0813 0.1453
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0813 0.4221
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0329 0.1484
Schistosoma mansoni lipoxygenase 0.0081 0.0866 0.1082
Treponema pallidum NADH oxidase 0.0064 0.0626 0.5
Loa Loa (eye worm) cysteine protease 0.0078 0.0813 0.1453
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.047 0.6298 0.6192
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0149 0.0462
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0058 0.0544 0.0972
Mycobacterium tuberculosis Probable oxidoreductase 0.047 0.6298 0.6192
Brugia malayi Glycosyl hydrolases family 31 protein 0.0043 0.0329 0.0589
Trypanosoma cruzi cruzipain precursor, putative 0.0078 0.0813 0.1422
Toxoplasma gondii preprocathepsin c precursor, putative 0.003 0.0149 0.0252
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0813 0.4221
Schistosoma mansoni hypothetical protein 0.0335 0.4402 0.5498
Loa Loa (eye worm) hypothetical protein 0.003 0.0149 0.0266
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0042 0.0311 0.0389
Brugia malayi Cathepsin L-like precursor 0.0078 0.0813 0.1453
Plasmodium vivax vivapain-2 0.0078 0.0813 0.3506
Echinococcus multilocularis cathepsin b 0.042 0.5596 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0149 0.0266
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0115 0.1336 0.2387
Trichomonas vaginalis penicillin-binding protein, putative 0.0115 0.1336 0.718
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0064 0.0626 0.248
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.022 0.0392
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0067 0.0085
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0057 0.0531 0.0948
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.003 0.0149 0.0186
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0813 0.3312
Brugia malayi cathepsin L-like precursor 0.0078 0.0813 0.1453
Onchocerca volvulus 0.0115 0.1336 1
Echinococcus multilocularis cathepsin L 0.003 0.0149 0.0266
Echinococcus granulosus cathepsin l1 0.0078 0.0813 0.1453
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0813 0.4221
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.042 0.5596 0.6989
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0064 0.0626 0.2698
Brugia malayi cathepsin L precursor 0.003 0.0149 0.0266
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0078 0.0813 0.3506
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0064 0.0626 0.1118
Brugia malayi Bromodomain containing protein 0.0037 0.0251 0.0449
Brugia malayi Cathepsin L-like precursor 0.0078 0.0813 0.1453
Plasmodium vivax vivapain-1 0.003 0.0149 0.0643
Schistosoma mansoni aldehyde dehydrogenase 0.0256 0.331 0.4134
Schistosoma mansoni family M1 non-peptidase homologue (M01 family) 0.0023 0.0047 0.0058
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0064 0.0626 1
Entamoeba histolytica cysteine proteinase, putative 0.0078 0.0813 1
Loa Loa (eye worm) hypothetical protein 0.003 0.0149 0.0266
Brugia malayi cathepsin L-like cysteine proteinase 0.003 0.0149 0.0266
Trypanosoma brucei hypothetical protein, conserved 0.0115 0.1336 0.5633
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0064 0.0626 0.248
Giardia lamblia NADH oxidase lateral transfer candidate 0.0064 0.0626 0.283
Loa Loa (eye worm) hypothetical protein 0.004 0.0285 0.0509
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0813 0.1422
Brugia malayi Papain family cysteine protease containing protein 0.0078 0.0813 0.1453
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0078 0.0813 0.3312
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0813 0.4221
Trichomonas vaginalis sucrase-isomaltase, putative 0.0043 0.0329 0.1484
Echinococcus multilocularis cathepsin L cysteine protease 0.0078 0.0813 0.1453
Entamoeba histolytica cysteine protease, putative 0.003 0.0149 0.1095
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0423 0.5638 0.5514
Echinococcus granulosus cathepsin l cysteine peptidase 0.0078 0.0813 0.1453
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0043 0.0329 0.1484
Brugia malayi Inositol-1 0.0044 0.0342 0.0612
Mycobacterium ulcerans esterase/lipase LipP 0.0115 0.1336 0.3611
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0813 0.4221
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0423 0.5638 0.5514
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0329 0.0555
Brugia malayi Kelch motif family protein 0.0057 0.0531 0.0948
Mycobacterium tuberculosis Probable hydrolase 0.0115 0.1336 0.1088
Entamoeba histolytica cysteine protease, putative 0.003 0.0149 0.1095
Plasmodium falciparum thioredoxin reductase 0.0185 0.2319 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0078 0.0813 0.4221
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0064 0.0626 0.248
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0035 0.022 0.0392
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0423 0.5638 0.5514
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0329 0.1484
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0151 0.1834 0.3253
Entamoeba histolytica cysteine protease, putative 0.003 0.0149 0.1095
Loa Loa (eye worm) follicle stimulating hormone receptor 0.028 0.3646 0.6516
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0078 0.0813 0.4221
Echinococcus granulosus cathepsin L 0.003 0.0149 0.0266
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.003 0.0149 0.0186
Trichomonas vaginalis alpha-glucosidase, putative 0.0043 0.0329 0.1484
Entamoeba histolytica cysteine protease, putative 0.003 0.0149 0.1095
Loa Loa (eye worm) hypothetical protein 0.0078 0.0813 0.1453
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0188 0.2358 0.2945
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.003 0.0149 0.0462
Entamoeba histolytica cysteine protease, putative 0.003 0.0149 0.1095
Trichomonas vaginalis conserved hypothetical protein 0.003 0.0149 0.0462
Trypanosoma cruzi cysteine peptidase, putative 0.0078 0.0813 0.1422
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0035 0.022 0.0392
Trichomonas vaginalis mercuric reductase, putative 0.0064 0.0626 0.3161
Brugia malayi Thioredoxin reductase 0.0185 0.2319 0.4144

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 0.067 uM Inhibition of Very late antigen 4 (VLA-4) and VCAM-Ig fusion protein interaction ChEMBL. 12086484
IC50 (binding) = 0.067 uM Inhibition of Very late antigen 4 (VLA-4) and VCAM-Ig fusion protein interaction ChEMBL. 12086484

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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