Detailed information for compound 1681501

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 188.269 | Formula: C12H16N2
  • H donors: 1 H acceptors: 0 LogP: 1.92 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@@H]1CNC[C@@H]2N1c1ccccc1C2
  • InChi: 1S/C12H16N2/c1-9-7-13-8-11-6-10-4-2-3-5-12(10)14(9)11/h2-5,9,11,13H,6-8H2,1H3/t9-,11-/m1/s1
  • InChiKey: NITMFLAGDPNBNV-MWLCHTKSSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_144688 All targets in OG5_144688
Brugia malayi Serotonin receptor Get druggable targets OG5_135430 All targets in OG5_135430
Echinococcus granulosus hypothetical protein Get druggable targets OG5_144688 All targets in OG5_144688
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Treponema pallidum peptidyl-prolyl cis-trans isomerase, FKBP-type, 22 kDa (fklB) 0.0055 0.0087 1
Onchocerca volvulus 0.0103 0.0188 0.3556
Plasmodium falciparum peptidyl-prolyl cis-trans isomerase FKBP35 0.0055 0.0087 0.1564
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.132 0.2778 0.2776
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0254 0.051 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.2927 0.6198 0.7427
Brugia malayi Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog 0.0023 0.0017 0.0021
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Schistosoma mansoni hypothetical protein 0.0103 0.0188 0.0223
Echinococcus multilocularis receptor type tyrosine protein phosphatase F 0.002 0.0011 0.0009
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.132 0.2778 0.3322
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0103 0.0188 0.0186
Echinococcus granulosus rhodopsin orphan GPCR 0.0103 0.0188 0.0186
Leishmania major beta tubulin 0.0023 0.0018 0.0011
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.3935 0.8344 0.8344
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0103 0.0188 0.0186
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Toxoplasma gondii beta-tubulin, putative 0.0023 0.0018 0.0014
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0103 0.0188 0.0186
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0103 0.0188 0.0186
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.002 0.0011 0.0009
Trichomonas vaginalis PIKK family atypical protein kinase 0.2121 0.4485 0.5373
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0254 0.051 0.0601
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0254 0.051 0.0508
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0254 0.051 0.0608
Brugia malayi hypothetical protein 0.0103 0.0188 0.0226
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0254 0.051 0.0601
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0022 0.0268
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0744 0.1553 0.1862
Trichomonas vaginalis PIKK family atypical protein kinase 0.2125 0.4491 0.5382
Trichomonas vaginalis PIKK family atypical protein kinase 0.0744 0.1553 0.1859
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0254 0.051 0.0601
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0103 0.0188 0.0226
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0744 0.1553 0.1853
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0744 0.1553 0.1853
Loa Loa (eye worm) hypothetical protein 0.0186 0.0366 0.0439
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.002 0.0011 0.0013
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0254 0.051 0.0608
Loa Loa (eye worm) hypothetical protein 0.0026 0.0025 0.003
Loa Loa (eye worm) phosphatidylinositol 3 0.0254 0.051 0.0611
Loa Loa (eye worm) CAMK protein kinase 0.002 0.0012 0.0015
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0103 0.0188 0.0186
Loa Loa (eye worm) phosphatidylinositol 3 0.0254 0.051 0.0611
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Leishmania major hypothetical protein, conserved 0.0025 0.0022 0.0016
Giardia lamblia Beta tubulin 0.0023 0.0018 0.0011
Echinococcus multilocularis fk506 binding protein 0.0055 0.0087 0.0085
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.3133 0.6637 0.7952
Echinococcus multilocularis neuropeptide s receptor 0.0103 0.0188 0.0186
Entamoeba histolytica phosphatidylinositol 4-kinase, putative 0.0254 0.051 0.0601
Echinococcus granulosus tm gpcr rhodopsin 0.0103 0.0188 0.0186
Schistosoma mansoni biogenic amine (5HT) receptor 0.0103 0.0188 0.0223
Schistosoma mansoni titin 0.002 0.0012 0.0012
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0004 0.0002
Echinococcus multilocularis g-protein coupled receptor 0.0103 0.0188 0.0186
Leishmania major beta tubulin 0.0023 0.0018 0.0011
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.002 0.0011 0.0013
Echinococcus multilocularis G protein coupled receptor 139 0.0103 0.0188 0.0186
Echinococcus granulosus phosphatidylinositol 3 kinase catalytic subunit 0.0254 0.051 0.0508
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0254 0.051 0.0508
Loa Loa (eye worm) hypothetical protein 0.0051 0.0078 0.0094
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.132 0.2778 0.3322
Onchocerca volvulus 0.0103 0.0188 0.3556
Echinococcus granulosus voltage gated potassium channel 0.0023 0.0017 0.0015
Echinococcus multilocularis 0.0254 0.051 0.0508
Schistosoma mansoni immunophilin FK506 binding protein FKBP12 0.0055 0.0087 0.0102
Echinococcus multilocularis Tubulin beta 2C chain 0.0023 0.0018 0.0016
Echinococcus multilocularis Tubulin beta 2C chain 0.0023 0.0018 0.0016
Trichomonas vaginalis tubulin, putative 0.0023 0.0018 0.0019
Trichomonas vaginalis PIKK family atypical protein kinase 0.313 0.663 0.7946
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0015 0.0002 0.0003
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0055 0.0087 0.0094
Leishmania major phosphatidylinositol 3-kinase, putative 0.132 0.2778 0.3322
Schistosoma mansoni tubulin subunit beta 0.0023 0.0018 0.0019
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.132 0.2778 0.3329
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0254 0.051 0.0608
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0254 0.051 0.0809
Trichomonas vaginalis PIKK family atypical protein kinase 0.132 0.2778 0.3327
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0078 0.0094
Onchocerca volvulus 0.0027 0.0026 0.031
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0254 0.051 0.0611
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0254 0.051 0.0508
Echinococcus granulosus rhodopsin orphan GPCR 0.0103 0.0188 0.0186
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0004 0.0005
Trichomonas vaginalis PIKK family atypical protein kinase 0.2927 0.6198 0.7427
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0254 0.051 0.0508
Trichomonas vaginalis PIKK family atypical protein kinase 0.313 0.663 0.7946
Schistosoma mansoni tubulin subunit beta 0.0023 0.0018 0.0019
Onchocerca volvulus 0.0103 0.0188 0.3556
Echinococcus multilocularis neuropeptide Y receptor 0.0103 0.0188 0.0186
Leishmania major peptidylprolyl isomerase-like protein 0.0055 0.0087 0.0094
Echinococcus multilocularis DNA dependent protein kinase catalytic subunit 0.0254 0.051 0.0508
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0254 0.051 0.0601
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0103 0.0188 0.3556
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0254 0.051 0.0611
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Echinococcus multilocularis fmrfamide receptor 0.0103 0.0188 0.0186
Echinococcus multilocularis rhodopsin orphan GPCR 0.0103 0.0188 0.0186
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0254 0.051 0.0601
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Schistosoma mansoni immunophilin 0.0055 0.0087 0.0102
Trichomonas vaginalis PIKK family atypical protein kinase 0.132 0.2778 0.3327
Echinococcus granulosus Tubulin beta 2C chain 0.0023 0.0018 0.0016
Brugia malayi Tachykinin-like peptides receptor 99D 0.0103 0.0188 0.0226
Echinococcus multilocularis contactin neuroglian septate junction protein 0.002 0.0011 0.0009
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Schistosoma mansoni cell adhesion molecule 0.002 0.0011 0.001
Echinococcus multilocularis transfer RNA-Phe 0.002 0.0011 0.0009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0103 0.0188 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0829 0.1734 0.2076
Trichomonas vaginalis PIKK family atypical protein kinase 0.049 0.1013 0.1212
Schistosoma mansoni cell adhesion molecule 0.002 0.0011 0.001
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0055 0.0087 0.0085
Brugia malayi phosphatidylinositol 4-kinase, catalytic, alpha polypeptide 0.0254 0.051 0.0611
Loa Loa (eye worm) hypothetical protein 0.0048 0.0071 0.0085
Echinococcus multilocularis serine protein kinase ATM 0.0744 0.1553 0.1551
Echinococcus multilocularis rhodopsin orphan GPCR 0.0103 0.0188 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.1056 0.2216 0.2654
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Echinococcus multilocularis musashi 0.0027 0.0026 0.0024
Echinococcus granulosus GPCR family 2 0.0016 0.0004 0.0002
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.3935 0.8344 0.8344
Leishmania major beta tubulin 0.0023 0.0018 0.0011
Echinococcus multilocularis g protein coupled receptor 0.0103 0.0188 0.0186
Loa Loa (eye worm) beta-tubulin 0.0023 0.0018 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0103 0.0188 0.0223
Trichomonas vaginalis phosphatidylinositol 4-kinase, putative 0.0254 0.051 0.0608
Plasmodium falciparum phosphatidylinositol 4-kinase 0.0254 0.051 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.2927 0.6198 0.7427
Trichomonas vaginalis PIKK family atypical protein kinase 0.2927 0.6198 0.7427
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0254 0.051 0.0809
Echinococcus granulosus tm gpcr rhodopsin 0.0103 0.0188 0.0186
Echinococcus granulosus tubulin beta 1 chain 0.0023 0.0018 0.0016
Plasmodium vivax hypothetical protein, conserved 0.0254 0.051 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0254 0.051 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.0744 0.1553 0.1859
Entamoeba histolytica phosphatidylinositol 3-kinase 3, putative 0.0254 0.051 0.0601
Brugia malayi hypothetical protein 0.0016 0.0004 0.0004
Leishmania major beta tubulin 0.0023 0.0018 0.0011
Schistosoma mansoni amine GPCR 0.0103 0.0188 0.0223
Echinococcus multilocularis rhodopsin orphan GPCR 0.0103 0.0188 0.0186
Echinococcus granulosus serine:threonine protein kinase SMG1 0.0744 0.1553 0.1551
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.313 0.663 0.7946
Plasmodium falciparum tubulin beta chain 0.0023 0.0018 0.0178
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.002 0.0011 0.0009
Onchocerca volvulus 0.0254 0.051 1
Onchocerca volvulus 0.0103 0.0188 0.3556
Onchocerca volvulus 0.0103 0.0188 0.3556
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Brugia malayi Cyclic-nucleotide gated cation channel 0.0015 0.0002 0.0003
Mycobacterium leprae conserved hypothetical protein 0.0254 0.051 0.5
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0103 0.0188 0.0223
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0017 0.0018
Echinococcus granulosus Tubulin beta 2C chain 0.0023 0.0018 0.0016
Brugia malayi AKH receptor 0.0103 0.0188 0.0226
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0103 0.0188 0.0226
Schistosoma mansoni fkbp-rapamycin associated protein 0.0744 0.1553 0.1859
Onchocerca volvulus 0.0103 0.0188 0.3556
Schistosoma mansoni receptor tyrosine phosphatase type r2a 0.002 0.0011 0.001
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0254 0.051 0.0608
Brugia malayi sulfakinin receptor protein 0.0103 0.0188 0.0226
Echinococcus granulosus peptide allatostatin:somatostatin 0.0103 0.0188 0.0186
Trypanosoma brucei beta tubulin 0.0023 0.0018 0.0011
Leishmania major beta tubulin 0.0023 0.0018 0.0011
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Onchocerca volvulus 0.0027 0.0026 0.031
Echinococcus multilocularis beta tubulin 0.0023 0.0018 0.0016
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0002
Schistosoma mansoni hypothetical protein 0.0254 0.051 0.0608
Schistosoma mansoni lamin 0.0027 0.0026 0.0029
Schistosoma mansoni ap endonuclease 0.0019 0.0009 0.0008
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0103 0.0188 0.0223
Echinococcus multilocularis lamin dm0 0.0027 0.0026 0.0024
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0022 0.0016
Echinococcus multilocularis g protein coupled receptor 0.0103 0.0188 0.0186
Brugia malayi Immunoglobulin I-set domain containing protein 0.002 0.0011 0.0013
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0103 0.0188 0.0223
Loa Loa (eye worm) tubulin beta-1 chain 0.0023 0.0018 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.2351 0.4973 0.5959
Echinococcus multilocularis roundabout 2 0.002 0.0011 0.0009
Echinococcus granulosus neuropeptide receptor 0.0103 0.0188 0.0186
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Echinococcus multilocularis sex peptide receptor 0.0103 0.0188 0.0186
Leishmania major phosphatidylinositol 3-related kinase, putative 0.132 0.2778 0.3322
Echinococcus multilocularis peptidyl prolyl cis trans isomerase FKBP4 0.0048 0.0071 0.0069
Plasmodium falciparum phosphatidylinositol 3- and 4-kinase, putative 0.0254 0.051 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0103 0.0188 0.0226
Leishmania major beta tubulin 0.0023 0.0018 0.0011
Echinococcus granulosus serine:threonine protein kinase 0.0724 0.151 0.1508
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0055 0.0087 0.0094
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0103 0.0188 0.0223
Echinococcus granulosus rhodopsin orphan GPCR 0.0103 0.0188 0.0186
Leishmania major beta tubulin 0.0023 0.0018 0.0011
Brugia malayi Serotonin receptor 0.0103 0.0188 0.0226
Echinococcus multilocularis neuropeptides capa receptor 0.0103 0.0188 0.0186
Leishmania major beta tubulin 0.0023 0.0018 0.0011
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0254 0.051 0.0601
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0003
Schistosoma mansoni hypothetical protein 0.0103 0.0188 0.0223
Leishmania major phosphatidylinositol 3-kinase, putative 0.0254 0.051 0.0601
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0004 0.0002
Plasmodium vivax phosphatidylinositol 3- and 4-kinase, putative 0.0254 0.051 1
Trichomonas vaginalis tubulin gamma chain, putative 0.0023 0.0018 0.0019
Trichomonas vaginalis tubulin epsilon chain, putative 0.0023 0.0018 0.0019
Brugia malayi G protein-coupled receptor 0.0103 0.0188 0.0226
Trichomonas vaginalis PIKK family atypical protein kinase 0.132 0.2778 0.3327
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0254 0.051 0.0601
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.3935 0.8344 1
Schistosoma mansoni cell adhesion molecule 0.002 0.0011 0.001
Schistosoma mansoni intermediate filament proteins 0.0027 0.0026 0.0029
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0103 0.0188 0.0186
Schistosoma mansoni serine/threonine protein kinase 0.002 0.0012 0.0012
Schistosoma mansoni tubulin subunit beta 0.0023 0.0018 0.0019
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0103 0.0188 0.0223
Brugia malayi Immunoglobulin I-set domain containing protein 0.002 0.0011 0.0013
Loa Loa (eye worm) G-protein coupled receptor 0.0103 0.0188 0.0226
Brugia malayi Dopamine receptor protein 1 0.0103 0.0188 0.0226
Echinococcus granulosus tubulin beta 4A class IVa 0.0023 0.0018 0.0016
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0744 0.1553 0.1853
Onchocerca volvulus 0.0103 0.0188 0.3556
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0044 0.0053
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0103 0.0188 0.0223
Echinococcus granulosus receptor type tyrosine protein phosphatase 0.002 0.0011 0.0009
Leishmania major beta tubulin 0.0023 0.0018 0.0011
Echinococcus granulosus allatostatin A receptor 0.0103 0.0188 0.0186
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Echinococcus granulosus g protein coupled receptor 0.0103 0.0188 0.0186
Loa Loa (eye worm) hypothetical protein 0.0254 0.051 0.0611
Entamoeba histolytica hypothetical protein 0.0254 0.051 0.0601
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.049 0.1013 0.1205
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0078 0.0135 0.0133
Brugia malayi Immunoglobulin I-set domain containing protein 0.002 0.0011 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.2927 0.6198 0.7427
Trichomonas vaginalis PIKK family atypical protein kinase 0.2328 0.4924 0.59
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0009 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0575 0.1194 0.1429
Trichomonas vaginalis PIKK family atypical protein kinase 0.2125 0.4491 0.5382
Leishmania major phosphatidylinositol 4-kinase alpha, putative 0.0254 0.051 0.0601
Schistosoma mansoni immunophilin 0.0055 0.0087 0.0102
Brugia malayi Immunoglobulin I-set domain containing protein 0.002 0.0011 0.0013
Trypanosoma brucei C-8 sterol isomerase, putative 0.0365 0.0746 0.0884
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0254 0.051 0.0608
Echinococcus multilocularis GPCR, family 2 0.0016 0.0004 0.0002
Brugia malayi neuropeptide F receptor 0.0103 0.0188 0.0226
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0744 0.1553 0.1859
Echinococcus granulosus biogenic amine 5HT receptor 0.0103 0.0188 0.0186
Brugia malayi beta-tubulin, identical 0.0023 0.0018 0.0021
Schistosoma mansoni alpha-1 adrenergic receptor 0.0103 0.0188 0.0223
Echinococcus multilocularis Tubulin beta 2C chain 0.0023 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Toxoplasma gondii FATC domain-containing protein 0.0744 0.1553 0.2495
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0022 0.0268
Schistosoma mansoni nephrin 0.002 0.0011 0.001
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.1634 0.3448 0.4126
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0103 0.0188 0.0186
Echinococcus multilocularis neuroglian 0.002 0.0011 0.0009
Echinococcus granulosus Tubulin beta 2C chain 0.0023 0.0018 0.0016
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase, putative 0.0055 0.0087 0.0094
Mycobacterium tuberculosis Conserved hypothetical protein 0.0254 0.051 1
Brugia malayi Immunoglobulin I-set domain containing protein 0.002 0.0011 0.0013
Echinococcus granulosus neuropeptide receptor A26 0.0103 0.0188 0.0186
Echinococcus multilocularis roundabout 2 0.002 0.0011 0.0009
Echinococcus granulosus fmrfamide receptor 0.0103 0.0188 0.0186
Loa Loa (eye worm) tubulin beta chain 0.0023 0.0018 0.0021
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0103 0.0188 0.0226
Trypanosoma brucei beta tubulin 0.0023 0.0018 0.0011
Echinococcus multilocularis serine:threonine protein kinase 0.0724 0.151 0.1508
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0078 0.0094
Echinococcus granulosus roundabout 2 0.002 0.0011 0.0009
Echinococcus multilocularis neuropeptide FF receptor 2 0.0103 0.0188 0.0186
Entamoeba histolytica phosphatidylinositol-4,5-bisphosphate 3-kinase, putative 0.0254 0.051 0.0601
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase, putative 0.0055 0.0087 0.0094
Entamoeba histolytica hypothetical protein 0.0744 0.1553 0.1853
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0022 0.0016
Plasmodium vivax hypothetical protein 0.0254 0.051 1
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.3935 0.8344 1
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0055 0.0087 0.0085
Loa Loa (eye worm) phosphatidylinositol 3 0.0254 0.051 0.0611
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0002
Echinococcus granulosus nephrin 0.002 0.0011 0.0009
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0103 0.0188 0.0186
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0103 0.0188 0.0223
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0254 0.051 0.0601
Schistosoma mansoni opsin-like receptor 0.0103 0.0188 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.3359 0.7119 0.8532
Loa Loa (eye worm) phosphatidylinositol kinase 0.0254 0.051 0.0611
Loa Loa (eye worm) hypothetical protein 0.0025 0.0022 0.0027
Leishmania major beta tubulin 0.0023 0.0018 0.0011
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0009 0.5
Leishmania major fk506-binding protein 1-like protein 0.0055 0.0087 0.0094
Loa Loa (eye worm) G-protein coupled receptor 0.0103 0.0188 0.0226
Echinococcus multilocularis voltage gated potassium channel 0.0023 0.0017 0.0015
Echinococcus granulosus tubulin subunit beta 0.0023 0.0018 0.0016
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.3935 0.8344 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0254 0.051 0.0508
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0254 0.051 0.0508
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0009 0.0008
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0254 0.051 0.0608
Schistosoma mansoni biogenic amine receptor 0.0103 0.0188 0.0223
Loa Loa (eye worm) phosphatidylinositol 3 0.0254 0.051 0.0611
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0254 0.051 0.0608
Echinococcus multilocularis G-protein coupled receptor, putative 0.0103 0.0188 0.0186
Brugia malayi hypothetical protein 0.0103 0.0188 0.0226
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0103 0.0188 0.0223
Echinococcus multilocularis tubulin subunit beta 0.0023 0.0018 0.0016
Brugia malayi ORL1-like opioid receptor 0.0103 0.0188 0.0226
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0744 0.1553 0.1853
Echinococcus granulosus sex peptide receptor 0.0103 0.0188 0.0186
Giardia lamblia Beta tubulin 0.0023 0.0018 0.0011
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0254 0.051 0.0611
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.3935 0.8344 1
Schistosoma mansoni histamine h1 receptor 0.0103 0.0188 0.0223
Loa Loa (eye worm) hypothetical protein 0.049 0.1013 0.1214
Trichomonas vaginalis PIKK family atypical protein kinase 0.0254 0.051 0.0608
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.002 0.0012 0.0015
Onchocerca volvulus 0.0103 0.0188 0.3556
Brugia malayi Melatonin receptor type 1A 0.0103 0.0188 0.0226
Plasmodium vivax tubulin beta chain, putative 0.0023 0.0018 0.0178
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0026 0.0032
Echinococcus multilocularis serotonin receptor 0.0103 0.0188 0.0186
Schistosoma mansoni biogenic amine receptor 0.0103 0.0188 0.0223
Trichomonas vaginalis tubulin beta chain, putative 0.0023 0.0018 0.0019
Entamoeba histolytica hypothetical protein 0.0254 0.051 0.0601
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Echinococcus granulosus beta tubulin 0.0023 0.0018 0.0016
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0254 0.051 0.0601
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0004 0.0002
Loa Loa (eye worm) hypothetical protein 0.0744 0.1553 0.1862
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0254 0.051 0.0601
Onchocerca volvulus 0.0103 0.0188 0.3556
Trypanosoma brucei phosphatidylinositol 4-kinase alpha, putative 0.0254 0.051 0.0601
Loa Loa (eye worm) phosphatidylinositol 3 0.132 0.2778 0.3329
Brugia malayi FAT domain containing protein 0.0575 0.1194 0.1431
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Echinococcus multilocularis Tubulin beta 2C chain 0.0023 0.0018 0.0016
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.132 0.2778 0.3322
Trypanosoma brucei FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0055 0.0087 0.0094
Echinococcus multilocularis Zinc finger, PHD finger 0.0254 0.051 0.0508
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0254 0.051 0.0601
Entamoeba histolytica tubulin family protein 0.0023 0.0018 0.0011
Giardia lamblia Phosphatidylinositol 4-kinase 0.0254 0.051 0.0601
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Leishmania major beta tubulin 0.0023 0.0018 0.0011
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.3935 0.8344 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Brugia malayi putative neuropeptide receptor NPR1 0.0103 0.0188 0.0226
Loa Loa (eye worm) BEN-1 protein 0.0023 0.0018 0.0021
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Echinococcus granulosus rhodopsin orphan GPCR 0.0103 0.0188 0.0186
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0103 0.0188 0.0223
Schistosoma mansoni cell adhesion molecule 0.002 0.0011 0.001
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0103 0.0188 0.0186
Giardia lamblia Phosphoinositide-3-kinase, class 3 0.0254 0.051 0.0601
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0103 0.0188 0.0186
Echinococcus granulosus neuropeptide s receptor 0.0103 0.0188 0.0186
Echinococcus granulosus neuropeptides capa receptor 0.0103 0.0188 0.0186
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Schistosoma mansoni biogenic amine (5HT) receptor 0.0103 0.0188 0.0223
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Trichomonas vaginalis tubulin epsilon chain, putative 0.0023 0.0018 0.0019
Loa Loa (eye worm) phosphatidylinositol 3 0.0254 0.051 0.0611
Brugia malayi hypothetical protein 0.0103 0.0188 0.0226
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0254 0.051 0.0608
Schistosoma mansoni neuropeptide receptor 0.0103 0.0188 0.0223
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0103 0.0188 0.0223
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0103 0.0188 0.0186
Echinococcus granulosus beta tubulin 0.0023 0.0018 0.0016
Entamoeba histolytica hypothetical protein 0.0254 0.051 0.0601
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0103 0.0188 0.0186
Echinococcus multilocularis lamin 0.0027 0.0026 0.0024
Loa Loa (eye worm) phosphatidylinositol 4-kinase type 3 alpha isoform 1 0.0254 0.051 0.0611
Loa Loa (eye worm) neuropeptide F receptor 0.0103 0.0188 0.0226
Schistosoma mansoni tubulin subunit beta 0.0023 0.0018 0.0019
Echinococcus granulosus roundabout 2 0.002 0.0011 0.0009
Loa Loa (eye worm) phosphatidylinositol 3 0.3935 0.8344 1
Schistosoma mansoni amine GPCR 0.0103 0.0188 0.0223
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0254 0.051 0.0608
Onchocerca volvulus 0.0103 0.0188 0.3556
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0103 0.0188 0.0223
Echinococcus granulosus orexin receptor type 2 0.0103 0.0188 0.0186
Echinococcus multilocularis rhodopsin orphan GPCR 0.0103 0.0188 0.0186
Toxoplasma gondii beta-1 tubulin, putative 0.0023 0.0018 0.0014
Trypanosoma brucei beta tubulin 0.0023 0.0018 0.0011
Brugia malayi Immunoglobulin I-set domain containing protein 0.002 0.0012 0.0015
Schistosoma mansoni hypothetical protein 0.0103 0.0188 0.0223
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0103 0.0188 0.0186
Giardia lamblia Beta tubulin 0.0023 0.0018 0.0011
Schistosoma mansoni voltage-gated potassium channel 0.0085 0.015 0.0178
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Echinococcus granulosus Phosphatidylinositol 4 kinase type 2 beta 0.0254 0.051 0.0508
Trichomonas vaginalis PIKK family atypical protein kinase 0.313 0.663 0.7946
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type, putative 0.0055 0.0087 0.0094
Echinococcus granulosus 7TM GPCR rhodopsin 0.0103 0.0188 0.0186
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0254 0.051 0.0608
Trichomonas vaginalis PIKK family atypical protein kinase 0.3935 0.8344 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0103 0.0188 0.0186
Echinococcus granulosus lamin 0.0027 0.0026 0.0024
Leishmania major phosphatidylinositol kinase, putative 0.0254 0.051 0.0601
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0254 0.051 0.0608
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Schistosoma mansoni immunophilin 0.0048 0.0071 0.0082
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.132 0.2778 0.2776
Trypanosoma brucei target of rapamycin kinase 3, putative 0.3133 0.6637 0.7952
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0254 0.051 0.0601
Trypanosoma brucei phosphatidylinositol 3-kinase catalytic subunit, putative 0.0254 0.051 0.0601
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0365 0.0746 0.0884
Schistosoma mansoni lamin 0.0027 0.0026 0.0029
Echinococcus multilocularis tubulin beta 1 chain 0.0023 0.0018 0.0016
Brugia malayi Tubulin beta-1 chain 0.0023 0.0018 0.0021
Echinococcus multilocularis allatostatin A receptor 0.0103 0.0188 0.0186
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP1A 0.0055 0.0087 0.0085
Echinococcus granulosus neuropeptides capa receptor 0.0103 0.0188 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0254 0.051 0.0608
Brugia malayi G-protein coupled receptor 0.0103 0.0188 0.0226
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Echinococcus granulosus titin 0.002 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0078 0.0094
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0254 0.051 0.0611
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0103 0.0188 0.0186
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.4713 1 1
Echinococcus granulosus g-protein coupled receptor 0.0103 0.0188 0.0186
Brugia malayi neuropeptide F receptor 0.0103 0.0188 0.0226
Echinococcus granulosus rhodopsin orphan GPCR 0.0103 0.0188 0.0186
Echinococcus multilocularis roundabout 2 0.002 0.0011 0.0009
Trichomonas vaginalis tubulin alpha chain, putative 0.0023 0.0018 0.0019
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0254 0.051 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0103 0.0188 0.0223
Echinococcus multilocularis g protein coupled receptor 0.0103 0.0188 0.0186
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.3935 0.8344 1
Schistosoma mansoni hypothetical protein 0.0035 0.0044 0.005
Entamoeba histolytica tubulin family protein 0.0023 0.0018 0.0011
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0073 0.0124 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.2554 0.5406 0.6478
Echinococcus multilocularis titin 0.002 0.0012 0.001
Brugia malayi Immunoglobulin I-set domain containing protein 0.002 0.0011 0.0013
Echinococcus granulosus phosphatidylinositol 4 kinase beta 0.0254 0.051 0.0508
Schistosoma mansoni nephrin 0.002 0.0011 0.001
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Loa Loa (eye worm) hypothetical protein 0.0035 0.0044 0.0053
Echinococcus multilocularis neuropeptide receptor A26 0.0103 0.0188 0.0186
Echinococcus granulosus rhodopsin orphan GPCR 0.0103 0.0188 0.0186
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0103 0.0188 0.0186
Trypanosoma cruzi beta tubulin, putative 0.0023 0.0018 0.0011
Trichomonas vaginalis PIKK family atypical protein kinase 0.2927 0.6198 0.7427
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, FKBP-type , putative 0.0055 0.0087 0.0094
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0022 0.0016
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0078 0.0135 0.0162
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0103 0.0188 0.0223
Loa Loa (eye worm) FKBP5 protein 0.0055 0.0087 0.0105
Leishmania major phosphatidylinositol kinase related protein, putative 0.0254 0.051 0.0601
Loa Loa (eye worm) melatonin receptor type 1A 0.0103 0.0188 0.0226
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0103 0.0188 0.0186
Leishmania major beta tubulin 0.0023 0.0018 0.0011
Leishmania major C-8 sterol isomerase-like protein 0.0365 0.0746 0.0884
Schistosoma mansoni neuroglian 0.002 0.0011 0.001
Onchocerca volvulus 0.0103 0.0188 0.3556
Trichomonas vaginalis conserved hypothetical protein 0.049 0.1013 0.1212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.3935 0.8344 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0013
Brugia malayi putative neuropeptide receptor 0.0103 0.0188 0.0226
Schistosoma mansoni ap endonuclease 0.0019 0.0009 0.0008
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0254 0.051 0.0601
Echinococcus granulosus neuroglian 0.002 0.0011 0.0009
Onchocerca volvulus 0.0254 0.051 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0103 0.0188 0.0186
Echinococcus multilocularis receptor type tyrosine protein phosphatase 0.002 0.0011 0.0009
Schistosoma mansoni neuropeptide F-like receptor 0.0103 0.0188 0.0223
Loa Loa (eye worm) cyclic-nucleotide gated cation channel 0.0015 0.0002 0.0003
Loa Loa (eye worm) MH2 domain-containing protein 0.0118 0.022 0.0264
Schistosoma mansoni amine GPCR 0.0103 0.0188 0.0223
Schistosoma mansoni opsin-like receptor 0.0103 0.0188 0.0223
Echinococcus granulosus peptidyl prolyl cis trans isomerase FKBP4 0.0048 0.0071 0.0069
Brugia malayi hypothetical protein 0.0025 0.0022 0.0027
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0078 0.0135 0.0133
Giardia lamblia 70 kDa peptidylprolyl isomerase, putative 0.0055 0.0087 0.0094
Trypanosoma cruzi phosphatidylinositol kinase, putative 0.0254 0.051 0.0601
Echinococcus multilocularis rhodopsin orphan GPCR 0.0103 0.0188 0.0186
Echinococcus granulosus lamin dm0 0.0027 0.0026 0.0024
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0103 0.0188 0.0226
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0103 0.0188 0.0223
Brugia malayi protein unc-22 0.002 0.0012 0.0015
Brugia malayi hypothetical protein 0.0103 0.0188 0.0226
Loa Loa (eye worm) tubulin beta-2A chain 0.0023 0.0018 0.0021
Echinococcus multilocularis serine:threonine protein kinase SMG1 0.0744 0.1553 0.1551
Echinococcus granulosus g protein coupled receptor 0.0103 0.0188 0.0186
Echinococcus multilocularis orexin receptor type 2 0.0103 0.0188 0.0186
Schistosoma mansoni opsin-like receptor 0.0103 0.0188 0.0223
Echinococcus multilocularis PIK kinase, FAT and Armadillo domain containing protein 0.0575 0.1194 0.1192
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0023 0.0017 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.2927 0.6198 0.7427
Entamoeba histolytica protein kinase rad3, putative 0.0744 0.1553 0.1853
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.132 0.2778 0.3322
Echinococcus multilocularis beta tubulin 0.0023 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Loa Loa (eye worm) hypothetical protein 0.0254 0.051 0.0611
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0009 0.0007
Echinococcus granulosus G protein coupled receptor 139 0.0103 0.0188 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.2125 0.4491 0.5382
Leishmania major hypothetical protein, unknown function 0.0254 0.051 0.0601
Trichomonas vaginalis PIKK family atypical protein kinase 0.2125 0.4491 0.5382
Leishmania major beta tubulin 0.0023 0.0018 0.0011
Loa Loa (eye worm) hypothetical protein 0.0829 0.1734 0.2079
Loa Loa (eye worm) BEN-1 protein 0.0023 0.0018 0.0021
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0103 0.0188 0.0223
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0103 0.0188 0.0226
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0023 0.0018 0.0016
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0002
Schistosoma mansoni voltage-gated potassium channel 0.0023 0.0017 0.0018
Echinococcus multilocularis dro:myosuppressin receptor 0.0103 0.0188 0.0186
Loa Loa (eye worm) hypothetical protein 0.0016 0.0004 0.0005
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0254 0.051 0.0608
Leishmania major beta tubulin 0.0023 0.0018 0.0011
Echinococcus granulosus neuropeptide Y receptor 0.0103 0.0188 0.0186
Leishmania major beta tubulin 0.0023 0.0018 0.0011
Schistosoma mansoni neuropeptide receptor 0.0103 0.0188 0.0223
Echinococcus multilocularis neuropeptide receptor 0.0103 0.0188 0.0186
Echinococcus granulosus neuropeptide receptor 0.0103 0.0188 0.0186
Echinococcus granulosus Tubulin beta 2C chain 0.0023 0.0018 0.0016
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Schistosoma mansoni amine GPCR 0.0103 0.0188 0.0223
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0254 0.051 0.0809
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0103 0.0188 0.0223
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Plasmodium vivax phosphatidylinositol 4-kinase, putative 0.0254 0.051 1
Schistosoma mansoni tubulin subunit beta 0.0023 0.0018 0.0019
Echinococcus granulosus neuropeptide FF receptor 2 0.0103 0.0188 0.0186
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-59, BmFKBP59 0.0055 0.0087 0.0105
Echinococcus granulosus PIK kinase FAT and Armadillo domain containing protein 0.0575 0.1194 0.1192
Echinococcus multilocularis conserved hypothetical protein 0.0833 0.1743 0.1741
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0805 0.1683 0.1682
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0002
Echinococcus multilocularis rhodopsin orphan GPCR 0.0103 0.0188 0.0186
Echinococcus granulosus contactin 0.002 0.0011 0.0009
Schistosoma mansoni growth hormone secretagogue receptor 0.0103 0.0188 0.0223
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0103 0.0188 0.0226
Brugia malayi hypothetical protein 0.0103 0.0188 0.0226
Brugia malayi MH2 domain containing protein 0.0118 0.022 0.0264
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0009 0.0007
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0103 0.0188 0.0223
Leishmania major beta tubulin 0.0023 0.0018 0.0011
Entamoeba histolytica hypothetical protein 0.0254 0.051 0.0601
Loa Loa (eye worm) FKBP-type peptidyl-prolyl cis-trans isomerase-12 0.0055 0.0087 0.0105
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.3935 0.8344 1
Plasmodium vivax 70 kDa peptidylprolyl isomerase, putative 0.0055 0.0087 0.1564
Onchocerca volvulus 0.0103 0.0188 0.3556
Brugia malayi hypothetical protein 0.0103 0.0188 0.0226
Schistosoma mansoni phosphatidylinositol 4-kinase 0.0254 0.051 0.0608
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0254 0.051 0.0601
Brugia malayi Immunoglobulin I-set domain containing protein 0.002 0.0011 0.0013
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0365 0.0746 0.0894
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0009 0.0011
Echinococcus multilocularis phosphatidylinositol 4 kinase alpha 0.0254 0.051 0.0508
Trichomonas vaginalis fk506-binding protein, putative 0.0055 0.0087 0.0102
Loa Loa (eye worm) hypothetical protein 0.0575 0.1194 0.1431
Trichomonas vaginalis PIKK family atypical protein kinase 0.313 0.663 0.7946
Trichomonas vaginalis PIKK family atypical protein kinase 0.2328 0.4924 0.59
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0829 0.1734 0.2788
Echinococcus granulosus roundabout 2 0.002 0.0011 0.0009
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0004 0.0005
Brugia malayi Dopamine receptor protein 2 0.0103 0.0188 0.0226
Trypanosoma cruzi target of rapamycin kinase 3 0.3133 0.6637 0.7952
Giardia lamblia Hypothetical protein 0.0254 0.051 0.0601
Plasmodium falciparum phosphatidylinositol 3-kinase 0.0254 0.051 1
Onchocerca volvulus 0.0103 0.0188 0.3556
Schistosoma mansoni hypothetical protein 0.002 0.0011 0.001
Echinococcus granulosus biogenic amine 5HT receptor 0.0103 0.0188 0.0186
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0103 0.0188 0.0223
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0254 0.051 0.0611
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0254 0.051 0.0608
Echinococcus granulosus alpha 1A adrenergic receptor 0.0103 0.0188 0.0186
Echinococcus multilocularis serotonin receptor 0.0103 0.0188 0.0186
Giardia lamblia GTOR 0.3935 0.8344 1
Echinococcus multilocularis neuropeptides capa receptor 0.0103 0.0188 0.0186
Schistosoma mansoni hypothetical protein 0.0575 0.1194 0.1429
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.002 0.0012 0.0015
Echinococcus granulosus serine protein kinase ATM 0.0744 0.1553 0.1551
Loa Loa (eye worm) hypothetical protein 0.0365 0.0746 0.0894
Echinococcus granulosus neuropeptide Y receptor 0.0103 0.0188 0.0186
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0026 0.0032
Brugia malayi intermediate filament protein 0.0027 0.0026 0.0032
Leishmania major phosphatidylinositol 4-kinase, putative 0.0254 0.051 0.0601
Loa Loa (eye worm) transcription factor SMAD2 0.0118 0.022 0.0264
Trichomonas vaginalis PIKK family atypical protein kinase 0.2351 0.4973 0.5959
Echinococcus granulosus DNA dependent protein kinase catalytic subunit 0.0254 0.051 0.0508
Trichomonas vaginalis immunophilin, putative 0.0055 0.0087 0.0102
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0103 0.0188 0.0186
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0103 0.0188 0.0226
Echinococcus multilocularis myosin light chain kinase, smooth muscle 0.0724 0.151 0.1508
Trichomonas vaginalis PIKK family atypical protein kinase 0.2351 0.4973 0.5959
Brugia malayi G protein-coupled receptor F59B2.13 0.0103 0.0188 0.0226
Echinococcus granulosus hypothetical protein 0.0936 0.1962 0.196
Onchocerca volvulus 0.002 0.0012 0.0029
Loa Loa (eye worm) hypothetical protein 0.0068 0.0113 0.0136
Giardia lamblia FKBP-type peptidyl-prolyl cis-trans isomerase 0.0055 0.0087 0.0094
Brugia malayi RE15519p 0.0103 0.0188 0.0226
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0103 0.0188 0.0226
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0254 0.051 0.0608
Echinococcus multilocularis Phosphatidylinositol 4 kinase type 2 beta 0.0254 0.051 0.0508
Schistosoma mansoni phosphatidylinositol 4-kinase type-II 0.0254 0.051 0.0608
Loa Loa (eye worm) projectin 0.002 0.0011 0.0013
Echinococcus multilocularis neuropeptide receptor 0.0103 0.0188 0.0186
Loa Loa (eye worm) TYRA-2 protein 0.0103 0.0188 0.0226
Echinococcus granulosus dro:myosuppressin receptor 0.0103 0.0188 0.0186
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0013
Loa Loa (eye worm) neuropeptide F receptor 0.0103 0.0188 0.0226
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.132 0.2778 0.3327
Echinococcus granulosus intermediate filament protein 0.0027 0.0026 0.0024
Echinococcus granulosus g protein coupled receptor 0.0103 0.0188 0.0186
Echinococcus granulosus somatostatin receptor 0.0103 0.0188 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0744 0.1553 0.1859
Trichomonas vaginalis PIKK family atypical protein kinase 0.132 0.2778 0.3327
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0744 0.1553 0.1862
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0023 0.0017 0.0015
Trichomonas vaginalis PIKK family atypical protein kinase 0.3935 0.8344 1
Schistosoma mansoni tubulin subunit beta 0.0023 0.0018 0.0019
Brugia malayi larval opioid receptor 0.0103 0.0188 0.0226
Onchocerca volvulus Neuropeptide F receptor homolog 0.0103 0.0188 0.3556
Brugia malayi follicle stimulating hormone receptor 0.0103 0.0188 0.0226
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Trypanosoma cruzi phosphatidylinositol 4-kinase alpha, putative 0.0254 0.051 0.0601
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0022 0.0022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0103 0.0188 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.2121 0.4485 0.5373
Echinococcus granulosus titin 0.002 0.0012 0.001
Loa Loa (eye worm) hypothetical protein 0.0027 0.0026 0.0032
Trichomonas vaginalis PIKK family atypical protein kinase 0.2639 0.5587 0.6695
Plasmodium vivax phosphatidylinositol 3-kinase, putative 0.0254 0.051 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0011 0.0013
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.1861 0.393 0.4704
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0103 0.0188 0.0223
Schistosoma mansoni myosin-binding protein-related 0.002 0.0011 0.001
Onchocerca volvulus 0.0103 0.0188 0.3556
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0103 0.0188 0.0186
Echinococcus granulosus myosin light chain kinase smooth muscle 0.0724 0.151 0.1508
Loa Loa (eye worm) hypothetical protein 0.0802 0.1676 0.2009
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0055 0.0087 0.0102
Loa Loa (eye worm) hypothetical protein 0.0023 0.0017 0.0021
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0073 0.0124 0.0146
Brugia malayi Dopamine receptor 0.0103 0.0188 0.0226
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Echinococcus multilocularis fmrfamide receptor 0.0103 0.0188 0.0186
Schistosoma mansoni biogenic amine receptor 0.0103 0.0188 0.0223
Trichomonas vaginalis peptidylprolyl isomerase, putative 0.0055 0.0087 0.0102
Brugia malayi hypothetical protein 0.0103 0.0188 0.0226
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0009 0.0008
Schistosoma mansoni myosin xvIII 0.0103 0.0188 0.0223
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0254 0.051 0.0611
Onchocerca volvulus 0.0103 0.0188 0.3556
Brugia malayi FKBP-type peptidyl-prolyl cis-trans isomerase-12, BmFKBP-12 0.0055 0.0087 0.0105
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.3935 0.8344 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0103 0.0188 0.0186
Schistosoma mansoni neuropeptide receptor 0.0103 0.0188 0.0223
Echinococcus multilocularis neuropeptide Y receptor 0.0103 0.0188 0.0186
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Trypanosoma brucei beta tubulin 0.0023 0.0018 0.0011
Mycobacterium ulcerans FK-506 binding protein, peptidyl-prolyl cis-trans isomerase 0.0055 0.0087 1
Toxoplasma gondii target of rapamycin (TOR), putative 0.2927 0.6198 1
Schistosoma mansoni amine GPCR 0.0103 0.0188 0.0223
Schistosoma mansoni hemicentin 0.002 0.0011 0.001
Echinococcus granulosus serotonin receptor 0.0103 0.0188 0.0186
Echinococcus multilocularis somatostatin receptor 0.0103 0.0188 0.0186
Echinococcus multilocularis Tubulin beta 2C chain 0.0023 0.0018 0.0016
Leishmania major hypothetical protein, conserved 0.0254 0.051 0.0601
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.002 0.0011 0.0013
Trypanosoma cruzi phosphatidylinositol 4-kinase, putative 0.0254 0.051 0.0601
Onchocerca volvulus 0.0103 0.0188 0.3556
Loa Loa (eye worm) tubulin beta-4 chain 0.0023 0.0018 0.0021
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0254 0.051 0.0809
Leishmania major beta tubulin 0.0023 0.0018 0.0011
Brugia malayi hypothetical protein 0.0103 0.0188 0.0226
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Schistosoma mansoni hypothetical protein 0.0103 0.0188 0.0223
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0022 0.0268
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0004 0.0005
Leishmania major beta tubulin 0.0023 0.0018 0.0011
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0078 0.0135 0.0162
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0254 0.051 0.0608
Loa Loa (eye worm) hypothetical protein 0.0103 0.0188 0.0226
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0004 0.0002
Brugia malayi hypothetical protein 0.0103 0.0188 0.0226
Trypanosoma cruzi FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative 0.0055 0.0087 0.0094
Brugia malayi Immunoglobulin I-set domain containing protein 0.002 0.0011 0.0013
Echinococcus granulosus rhodopsin orphan GPCR 0.0103 0.0188 0.0186
Brugia malayi G-protein coupled receptor 0.0103 0.0188 0.0226
Schistosoma mansoni neuropeptide f receptor 76f 0.0103 0.0188 0.0223
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0026 0.0032
Brugia malayi GnHR receptor homolog 0.0103 0.0188 0.0226
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0103 0.0188 0.0226
Schistosoma mansoni phosphatidylinositol 3-kinase class 0.0254 0.051 0.0608
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0103 0.0188 0.0223
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.3935 0.8344 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0103 0.0188 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.2121 0.4485 0.5373
Brugia malayi Immunoglobulin I-set domain containing protein 0.002 0.0011 0.0013
Schistosoma mansoni neuropeptide receptor 0.0103 0.0188 0.0223
Onchocerca volvulus 0.0103 0.0188 0.3556
Schistosoma mansoni titin 0.002 0.0011 0.001
Echinococcus granulosus phosphatidylinositol 4 kinase alpha 0.0254 0.051 0.0508
Toxoplasma gondii phosphatidylinositol 3- and 4-kinase 0.0254 0.051 0.0809
Echinococcus granulosus Tubulin beta 2C chain 0.0023 0.0018 0.0016
Trichomonas vaginalis PIKK family atypical protein kinase 0.132 0.2778 0.3327
Trichomonas vaginalis PIKK family atypical protein kinase 0.3935 0.8344 1
Brugia malayi Serotonin receptor 0.0658 0.1371 0.1643
Schistosoma mansoni voltage-gated potassium channel 0.0085 0.015 0.0178
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.002 0.0011 0.0013
Schistosoma mansoni adenoreceptor 0.0103 0.0188 0.0223
Toxoplasma gondii beta tubulin 0.0023 0.0018 0.0014
Schistosoma mansoni neuropeptide F-like receptor 0.0103 0.0188 0.0223
Brugia malayi hypothetical protein 0.0103 0.0188 0.0226

Activities

Activity type Activity value Assay description Source Reference
Efficacy (binding) = 97 % Relative efficacy toward 5-HT2C receptor ChEMBL. 15975787
Ki (binding) = 1.9 nM Binding affinity toward 5-HT2A receptor evaluated by displacement of [125I]-DOI radioligand ChEMBL. 15975787
Ki (binding) = 2.2 nM Binding affinity toward 5-HT2C receptor evaluated by displacement of [3H]-5-HT radioligand ChEMBL. 15975787
Ki (binding) = 15 nM Binding affinity toward 5-HT2B receptor evaluated by displacement of [3H]-5-HT radioligand ChEMBL. 15975787

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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