Detailed information for compound 1694292

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 490.515 | Formula: C26H29F3N2O4
  • H donors: 0 H acceptors: 2 LogP: 4.47 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)[C@@H]1Cc2c(N(C(=O)[C@@H]1OC(=O)C)C[C@H]1CCCN1C)cccc2C(F)(F)F
  • InChi: 1S/C26H29F3N2O4/c1-16(32)35-24-20(17-9-11-19(34-3)12-10-17)14-21-22(26(27,28)29)7-4-8-23(21)31(25(24)33)15-18-6-5-13-30(18)2/h4,7-12,18,20,24H,5-6,13-15H2,1-3H3/t18-,20+,24-/m1/s1
  • InChiKey: DMBNNPMTRSVDEP-LJFZDNNRSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major UDP-galactopyranose mutase 0.0041 0.0106 0.0395
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0346 0.1591 0.1591
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0041 0.0106 0.1177
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0106 0.1177
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0053 0.0053
Toxoplasma gondii hypothetical protein 0.0048 0.0139 0.1924
Echinococcus multilocularis peregrin 0.0032 0.0065 0.0065
Mycobacterium ulcerans dehydrogenase 0.0041 0.0106 0.0283
Mycobacterium ulcerans beta-lactamase 0.0075 0.0271 0.3169
Echinococcus multilocularis neuropeptide receptor A26 0.045 0.2096 0.2096
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0041 0.0106 1
Brugia malayi PHD-finger family protein 0.003 0.0053 0.0123
Echinococcus granulosus survival motor neuron protein 1 0.0229 0.1021 0.1021
Loa Loa (eye worm) transcription factor SMAD2 0.0117 0.0476 0.1166
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0122 0.0503 1
Toxoplasma gondii ABC1 family protein 0.0075 0.0271 0.4849
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0041 0.0106 0.0252
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.011 0.0427
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0025 0.003 0.003
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.011 0.0427
Echinococcus granulosus tumor protein p63 0.0327 0.1499 0.1499
Schistosoma mansoni microtubule-associated protein tau 0.2076 1 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.0135 0.0326
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0197 0.1105
Echinococcus multilocularis tumor protein p63 0.0327 0.1499 0.1499
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0053 0.0053
Schistosoma mansoni vesicular amine transporter 0.0186 0.0813 0.0813
Plasmodium vivax hypothetical protein, conserved 0.0075 0.0271 0.4849
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0109 0.0109
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0197 0.0503
Leishmania major hypothetical protein, conserved 0.0075 0.0271 0.1682
Schistosoma mansoni hypothetical protein 0.0081 0.0304 0.0304
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0037 0.0089 0.5
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0586 0.4132
Trypanosoma cruzi UDP-galactopyranose mutase 0.0041 0.0106 0.0395
Echinococcus multilocularis synaptic vesicular amine transporter 0.0186 0.0813 0.0813
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0041 0.0106 0.0283
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0075 0.0271 0.0662
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0093 0.0222
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0041 0.0106 0.0106
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0167 0.0167
Plasmodium vivax ataxin-2 like protein, putative 0.003 0.0055 0.0049
Schistosoma mansoni bromodomain containing protein 0.007 0.0249 0.0249
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0346 0.1591 0.1591
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0089 0.0213
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0081 0.0304 0.0304
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0167 0.0404
Trichomonas vaginalis esterase, putative 0.0075 0.0271 0.04
Schistosoma mansoni amine oxidase 0.0041 0.0106 0.0106
Echinococcus granulosus synaptic vesicular amine transporter 0.0186 0.0813 0.0813
Schistosoma mansoni hypothetical protein 0.0081 0.0304 0.0304
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0089 0.5
Loa Loa (eye worm) hypothetical protein 0.0053 0.0167 0.0403
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0295 0.1341 1
Mycobacterium tuberculosis Probable lipase LipD 0.0075 0.0271 0.085
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.1341 1
Onchocerca volvulus 0.0041 0.0106 0.0116
Echinococcus multilocularis polycomb protein SCMH1 0.0047 0.0135 0.0135
Echinococcus granulosus geminin 0.034 0.1559 0.1559
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0477 0.2227 1
Mycobacterium ulcerans hypothetical protein 0.0075 0.0271 0.3169
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0089 1
Onchocerca volvulus 0.0047 0.0135 0.0181
Echinococcus multilocularis protoporphyrinogen oxidase 0.0041 0.0106 0.0106
Schistosoma mansoni hypothetical protein 0.0081 0.0304 0.0304
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0122 0.0503 0.0503
Trypanosoma brucei hypothetical protein, conserved 0.0075 0.0271 0.1682
Mycobacterium tuberculosis Possible oxidoreductase 0.0041 0.0106 0.0076
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0141 0.0595 0.0595
Loa Loa (eye worm) beta-lactamase 0.0075 0.0271 0.0661
Mycobacterium ulcerans oxidoreductase 0.0041 0.0106 0.0283
Schistosoma mansoni hypothetical protein 0.0023 0.0019 0.0019
Schistosoma mansoni ap endonuclease 0.0037 0.0089 0.0089
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0081 0.0304 0.0304
Brugia malayi jmjC domain containing protein 0.0097 0.0381 0.0933
Loa Loa (eye worm) hypothetical protein 0.0075 0.0271 0.0661
Schistosoma mansoni hypothetical protein 0.0176 0.0763 0.0763
Mycobacterium ulcerans lipase LipD 0.0075 0.0271 0.3169
Mycobacterium ulcerans esterase/lipase LipP 0.0075 0.0271 0.3169
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0041 0.0106 0.0106
Loa Loa (eye worm) hypothetical protein 0.0047 0.0138 0.0332
Loa Loa (eye worm) hypothetical protein 0.0075 0.0271 0.0661
Echinococcus granulosus fetal alzheimer antigen falz 0.0025 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.0041 0.0106 0.0252
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0139 0.0586 0.4132
Echinococcus multilocularis pol protein 0.0634 0.2992 0.2992
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0089 0.0269
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0197 0.1876
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0097 0.0381 0.0381
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0431 0.2002 0.493
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.004 0.0102 0.0102
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0122 0.0503 0.0503
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0089 0.6934
Brugia malayi Pre-SET motif family protein 0.0122 0.0503 0.1234
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0093 0.0093
Brugia malayi hypothetical protein 0.003 0.0055 0.0128
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0141 0.0595 0.0595
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0284 0.0284
Brugia malayi hypothetical protein 0.0041 0.0106 0.0254
Plasmodium falciparum protoporphyrinogen oxidase 0.0041 0.0106 1
Brugia malayi jmjC domain containing protein 0.0038 0.0093 0.0223
Trichomonas vaginalis set domain proteins, putative 0.0971 0.463 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0346 0.1591 0.1591
Mycobacterium leprae Probable lipase LipE 0.0075 0.0271 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0106 0.0252
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0047 0.0135 0.0135
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0075 0.0271 0.085
Brugia malayi beta-lactamase 0.0075 0.0271 0.0662
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0197 0.0197
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.0186 0.0813 0.1998
Loa Loa (eye worm) hypothetical protein 0.0075 0.0271 0.0661
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0853 0.4057 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.084 0.084
Echinococcus multilocularis neuropeptide s receptor 0.045 0.2096 0.2096
Mycobacterium tuberculosis Conserved hypothetical protein 0.0041 0.0106 0.0076
Loa Loa (eye worm) hypothetical protein 0.0078 0.0289 0.0705
Schistosoma mansoni zinc finger protein 0.0022 0.0014 0.0014
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0346 0.1591 0.1591
Echinococcus granulosus GPCR family 2 0.0081 0.0304 0.0304
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0041 0.0106 0.1177
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0271 0.04
Toxoplasma gondii histone lysine-specific demethylase 0.0041 0.0106 0.1177
Loa Loa (eye worm) hypothetical protein 0.0081 0.0304 0.0741
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0346 0.1591 0.3916
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0167 0.0167
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0053 0.0122
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0089 0.0269
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0139 0.0586 0.4132
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0089 0.0212
Schistosoma mansoni hypothetical protein 0.0292 0.1326 0.1326
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0041 0.0106 0.1177
Loa Loa (eye worm) hypothetical protein 0.0045 0.0128 0.0306
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0122 0.0503 0.0503
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0066 0.023 0.023
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0047 0.0135 0.0181
Schistosoma mansoni ap endonuclease 0.0037 0.0089 0.0089
Loa Loa (eye worm) hypothetical protein 0.0048 0.0141 0.034
Echinococcus multilocularis zinc finger protein 0.0022 0.0014 0.0014
Echinococcus multilocularis GPCR, family 2 0.0081 0.0304 0.0304
Brugia malayi mbt repeat family protein 0.0047 0.0135 0.0327
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.011 0.0427
Loa Loa (eye worm) hypothetical protein 0.0229 0.1021 0.2511
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.0106 0.0106
Trichomonas vaginalis penicillin-binding protein, putative 0.0075 0.0271 0.04
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0141 0.0141
Loa Loa (eye worm) MH2 domain-containing protein 0.0117 0.0476 0.1166
Loa Loa (eye worm) hypothetical protein 0.003 0.0053 0.0122
Loa Loa (eye worm) latrophilin receptor protein 2 0.0081 0.0304 0.0741
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0167 0.0167
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0135 0.0135
Brugia malayi Pre-SET motif family protein 0.0853 0.4057 1
Schistosoma mansoni hypothetical protein 0.003 0.0053 0.0053
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0271 0.04
Echinococcus granulosus neuropeptide receptor A26 0.045 0.2096 0.2096
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0089 0.0269
Mycobacterium ulcerans hypothetical protein 0.0155 0.0663 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0066 0.023 0.023
Brugia malayi SWIRM domain containing protein 0.0041 0.0106 0.0254
Echinococcus granulosus zinc finger protein 0.0022 0.0014 0.0014
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0118 0.0481 0.0481
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0271 0.04
Schistosoma mansoni hypothetical protein 0.0047 0.0135 0.0135
Onchocerca volvulus 0.0075 0.0271 0.0477
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0346 0.1591 0.3917
Echinococcus granulosus neuropeptide s receptor 0.045 0.2096 0.2096
Schistosoma mansoni hypothetical protein 0.034 0.1559 0.1559
Onchocerca volvulus 0.0122 0.0503 0.0985
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0089 0.0089
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0346 0.1591 0.1591
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0197 0.0197
Echinococcus multilocularis geminin 0.034 0.1559 0.1559
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.011 0.0427
Echinococcus granulosus beta LACTamase domain containing family member 0.0075 0.0271 0.0271
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0346 0.1591 0.1591
Trypanosoma cruzi UDP-galactopyranose mutase 0.0041 0.0106 0.0395
Brugia malayi MH2 domain containing protein 0.0117 0.0476 0.1167
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0075 0.0271 0.3169
Loa Loa (eye worm) MBCTL1 0.0053 0.0167 0.0403
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0089 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0197 0.1876
Mycobacterium leprae conserved hypothetical protein 0.0075 0.0271 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0089 0.0089
Brugia malayi Bromodomain containing protein 0.0083 0.0312 0.0763
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0081 0.0304 0.0742
Echinococcus granulosus polycomb protein SCMH1 0.0047 0.0135 0.0135
Mycobacterium tuberculosis Probable esterase LipL 0.0075 0.0271 0.085
Brugia malayi Calcitonin receptor-like protein seb-1 0.0257 0.1158 0.2851
Brugia malayi hypothetical protein 0.0229 0.1021 0.2512
Brugia malayi PHD-finger family protein 0.0028 0.0042 0.0097
Echinococcus granulosus SAM and MBT domain containing protein 0.0047 0.0135 0.0135
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0197 0.3203
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.1341 1
Loa Loa (eye worm) hypothetical protein 0.0141 0.0595 0.146
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0075 0.0271 0.0661
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.084 0.084
Loa Loa (eye worm) hypothetical protein 0.0041 0.0106 0.0252
Plasmodium vivax hypothetical protein, conserved 0.0041 0.0106 0.1177
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0075 0.0271 0.085
Schistosoma mansoni sex comb on midleg homolog 0.0047 0.0135 0.0135
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0197 0.0197
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0271 0.0271
Schistosoma mansoni amine oxidase 0.0041 0.0106 0.0106
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0055 0.0413
Trichomonas vaginalis D-aminoacylase, putative 0.0075 0.0271 0.04
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0257 0.1158 0.285
Onchocerca volvulus 0.0971 0.463 1
Plasmodium vivax SET domain protein, putative 0.0122 0.0503 1
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0089 0.0269
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0089 0.0816
Brugia malayi Abnormal catecholamine distribution protein 1 0.0186 0.0813 0.1999
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0097 0.0381 0.0381
Brugia malayi beta-lactamase family protein 0.0075 0.0271 0.0662
Chlamydia trachomatis protoporphyrinogen oxidase 0.0041 0.0106 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0271 0.1682
Brugia malayi Latrophilin receptor protein 2 0.0081 0.0304 0.0742
Toxoplasma gondii exonuclease III APE 0.0037 0.0089 0.0816
Schistosoma mansoni hypothetical protein 0.0081 0.0304 0.0304
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0075 0.0271 0.0271
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0925 0.4407 0.4407
Loa Loa (eye worm) hypothetical protein 0.0075 0.0271 0.0661
Loa Loa (eye worm) hypothetical protein 0.0075 0.0271 0.0661
Mycobacterium tuberculosis Probable hydrolase 0.0075 0.0271 0.085
Loa Loa (eye worm) hypothetical protein 0.0176 0.0763 0.1874
Brugia malayi Bromodomain containing protein 0.0042 0.0114 0.0275
Brugia malayi latrophilin 2 splice variant baaae 0.0176 0.0763 0.1875
Trypanosoma cruzi hypothetical protein, conserved 0.0075 0.0271 0.1682
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0167 0.0167
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0041 0.0106 0.0283
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0206 0.0501
Onchocerca volvulus 0.0048 0.0141 0.0193
Loa Loa (eye worm) hypothetical protein 0.0431 0.2002 0.493
Loa Loa (eye worm) hypothetical protein 0.0075 0.0271 0.0661
Echinococcus multilocularis survival motor neuron protein 1 0.0229 0.1021 0.1021
Mycobacterium tuberculosis Conserved protein 0.0075 0.0271 0.085
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0255 0.1147 0.1147
Loa Loa (eye worm) hypothetical protein 0.0042 0.0115 0.0275
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0197 0.0197
Echinococcus multilocularis pol protein 0.0634 0.2992 0.2992
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0197 0.1876
Brugia malayi amine oxidase, flavin-containing family protein 0.0041 0.0106 0.0254
Onchocerca volvulus 0.0075 0.0271 0.0477
Mycobacterium tuberculosis Probable lipase LipE 0.0075 0.0271 0.085
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0167 0.0167
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0141 0.0595 0.0595
Echinococcus multilocularis beta LACTamase domain containing family member 0.0075 0.0271 0.0271
Onchocerca volvulus 0.0047 0.0135 0.0181
Echinococcus multilocularis pol protein 0.0634 0.2992 0.2992
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0053 0.0053
Schistosoma mansoni hypothetical protein 0.034 0.1559 0.1559
Toxoplasma gondii LsmAD domain-containing protein 0.003 0.0055 0.0049
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.005 0.0154 0.0769
Loa Loa (eye worm) PHD-finger family protein 0.0023 0.0019 0.0039
Echinococcus multilocularis microtubule associated protein 2 0.2076 1 1
Brugia malayi mbt repeat family protein 0.0047 0.0135 0.0327
Brugia malayi beta-lactamase family protein 0.0075 0.0271 0.0662
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0083 0.0083
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.004 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.003 0.0055 0.0127
Echinococcus multilocularis pol protein 0.0634 0.2992 0.2992
Loa Loa (eye worm) mbt repeat family protein 0.0047 0.0135 0.0326
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0255 0.1147 0.1147
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0041 0.0106 1
Loa Loa (eye worm) hypothetical protein 0.0041 0.0106 0.0252
Onchocerca volvulus 0.0075 0.0271 0.0477
Echinococcus granulosus lysine specific histone demethylase 1A 0.0041 0.0106 0.0106
Echinococcus multilocularis SAM and MBT domain containing protein 0.0047 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0041 0.0106 0.0252
Mycobacterium tuberculosis Conserved protein 0.0075 0.0271 0.085
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0346 0.1591 0.1591
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0093 0.0093
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0041 0.0106 0.0283
Brugia malayi Bromodomain containing protein 0.0032 0.0065 0.0154
Echinococcus granulosus peregrin 0.0032 0.0065 0.0065
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0109 0.0109
Schistosoma mansoni survival motor neuron protein 0.0047 0.0135 0.0135
Loa Loa (eye worm) hypothetical protein 0.0051 0.0156 0.0376
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0041 0.0106 0.0106
Echinococcus multilocularis 0.0041 0.0106 0.0106
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0663 0.2683
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0135 0.0327
Mycobacterium tuberculosis Conserved protein 0.0075 0.0271 0.085
Echinococcus granulosus histone lysine methyltransferase setb 0.0141 0.0595 0.0595
Mycobacterium ulcerans monoamine oxidase 0.0041 0.0106 0.0283
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0025 0.003 0.003
Plasmodium falciparum ataxin-2 like protein, putative 0.003 0.0055 0.0413
Leishmania major mitochondrial DNA polymerase beta 0.0295 0.1341 1
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0075 0.0271 0.085

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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