Detailed information for compound 16979

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 454.713 | Formula: C23H40N3O2S2+
  • H donors: 2 H acceptors: 4 LogP: 5.82 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC[N+](C)(C)C.CCSc1nnc(s1)c1cc(c(c(c1)C(C)(C)C)O)C(C)(C)C
  • InChi: 1S/C18H26N2OS2.C5H14NO/c1-8-22-16-20-19-15(23-16)11-9-12(17(2,3)4)14(21)13(10-11)18(5,6)7;1-6(2,3)4-5-7/h9-10,21H,8H2,1-7H3;7H,4-5H2,1-3H3/q;+1
  • InChiKey: QMBKNLJAXCEMIQ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0055 0.0144 0.0486
Loa Loa (eye worm) hypothetical protein 0.0455 0.208 0.2894
Schistosoma mansoni cathepsin S (C01 family) 0.0142 0.0564 0.0544
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0194 0.0173
Brugia malayi MH1 domain containing protein 0.0066 0.0198 0.0276
Echinococcus multilocularis baculoviral IAP repeat containing protein 0.0214 0.0914 0.0894
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0034 0.0045 0.015
Brugia malayi hypothetical protein 0.0065 0.0194 0.0271
Echinococcus granulosus g-protein coupled receptor 0.0065 0.0194 0.0173
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0045 0.0024
Schistosoma mansoni opsin-like receptor 0.0065 0.0194 0.0173
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0239 0.1031 0.1012
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0442 0.1473
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0066 0.0198 0.0177
Echinococcus granulosus dna polymerase eta 0.0117 0.0442 0.0422
Brugia malayi RNA recognition motif domain containing protein 0.0132 0.0518 0.0721
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0065 0.0194 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Leishmania major cathepsin L-like protease 0.0455 0.208 0.6928
Brugia malayi hypothetical protein 0.0065 0.0194 0.0271
Trypanosoma cruzi cruzipain precursor, putative 0.0052 0.0132 0.0183
Schistosoma mansoni hypothetical protein 0.0065 0.0194 0.0173
Echinococcus multilocularis aminopeptidase N 0.0034 0.0045 0.0024
Echinococcus granulosus cathepsin b 0.1512 0.7186 0.718
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0142 0.0564 0.2707
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Toxoplasma gondii hypothetical protein 0.0456 0.2084 0.7977
Plasmodium falciparum serine repeat antigen 9 0.0142 0.0564 0.2707
Echinococcus granulosus caspase 2 0.0123 0.0471 0.0451
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0065 0.0194 0.0173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0646 0.3002 1
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0142 0.0564 0.2022
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0142 0.0564 0.0544
Loa Loa (eye worm) prolyl oligopeptidase 0.0381 0.1719 0.2393
Brugia malayi Serotonin receptor 0.0065 0.0194 0.0271
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0117 0.0442 0.1473
Echinococcus multilocularis histone deacetylase 0.0043 0.0085 0.0063
Plasmodium falciparum serine repeat antigen 3 0.0142 0.0564 0.2707
Giardia lamblia Cathepsin B precursor 0.0142 0.0564 0.1995
Trypanosoma brucei serine peptidase, clan SC, family S9A-like protein 0.013 0.0506 0.1685
Echinococcus granulosus apoptotic protease activating factor 1 0.0123 0.0471 0.0451
Trypanosoma brucei chrX additional, unordered contigs 0.0036 0.0053 0.0178
Schistosoma mansoni alpha-1 adrenergic receptor 0.0065 0.0194 0.0173
Brugia malayi putative neuropeptide receptor NPR1 0.0065 0.0194 0.0271
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0518 0.0498
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Brugia malayi prolyl oligopeptidase family protein 0.0381 0.1719 0.2393
Entamoeba histolytica prolyl oligopeptidase family protein 0.0055 0.0144 0.0486
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.0053 0.0205
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0065 0.0194 0.0173
Brugia malayi RE15519p 0.0065 0.0194 0.0271
Entamoeba histolytica cysteine protease, putative 0.0194 0.0817 0.3795
Trypanosoma brucei DNA damage repair protein, putative 0.0036 0.0053 0.0178
Schistosoma mansoni caspase-7 (C14 family) 0.0123 0.0471 0.0451
Loa Loa (eye worm) histone deacetylase 0.0043 0.0085 0.0118
Brugia malayi Cathepsin L-like precursor 0.0455 0.208 0.2894
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0146 0.0584 0.0563
Schistosoma mansoni neuropeptide F-like receptor 0.0065 0.0194 0.0173
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0065 0.0194 0.0271
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Loa Loa (eye worm) hypothetical protein 0.0142 0.0564 0.0785
Brugia malayi mothers against decapentaplegic homolog 3 0.003 0.0022 0.003
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0518 0.0498
Schistosoma mansoni histone deacetylase 4 5 0.0043 0.0085 0.0063
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Brugia malayi putative neuropeptide receptor 0.0065 0.0194 0.0271
Echinococcus granulosus g protein coupled receptor 0.0065 0.0194 0.0173
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0045 0.0024
Toxoplasma gondii cathepsin CPC2 0.0142 0.0564 0.2159
Echinococcus granulosus cathepsin b 0.1512 0.7186 0.718
Schistosoma mansoni hypothetical protein 0.0065 0.0194 0.0173
Plasmodium falciparum serine repeat antigen 5 0.0142 0.0564 0.2707
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0194 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Loa Loa (eye worm) hypothetical protein 0.0123 0.0471 0.0656
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0142 0.0564 0.1995
Loa Loa (eye worm) hypothetical protein 0.0403 0.1827 0.2542
Giardia lamblia Cathepsin B precursor 0.0566 0.2612 1
Brugia malayi hypothetical protein 0.0065 0.0194 0.0271
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0194 0.0817 0.1137
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.0451 0.175
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Echinococcus granulosus neuropeptide receptor A26 0.0065 0.0194 0.0173
Mycobacterium ulcerans DNA polymerase IV 0.0117 0.0442 0.1948
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0455 0.208 0.7927
Entamoeba histolytica prolyl oligopeptidase family protein 0.0055 0.0144 0.0486
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0518 0.0498
Entamoeba histolytica cysteine protease, putative 0.0142 0.0564 0.255
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0267 0.089
Echinococcus multilocularis cathepsin L 0.0142 0.0564 0.0544
Entamoeba histolytica cysteine proteinase, putative 0.0194 0.0817 0.3795
Echinococcus multilocularis neuropeptide receptor 0.0065 0.0194 0.0173
Entamoeba histolytica cysteine protease, putative 0.0142 0.0564 0.255
Loa Loa (eye worm) thioredoxin reductase 0.0047 0.0104 0.0145
Schistosoma mansoni hypothetical protein 0.0036 0.005 0.0029
Loa Loa (eye worm) G-protein coupled receptor 0.0065 0.0194 0.0271
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0042 0.0082 0.0114
Loa Loa (eye worm) hypothetical protein 0.0037 0.0055 0.0077
Onchocerca volvulus 0.0065 0.0194 0.084
Entamoeba histolytica cysteine protease, putative 0.0194 0.0817 0.3795
Echinococcus granulosus thioredoxin glutathione reductase 0.0047 0.0104 0.0083
Onchocerca volvulus 0.0065 0.0194 0.084
Schistosoma mansoni neuropeptide F-like receptor 0.0065 0.0194 0.0173
Schistosoma mansoni transcription factor LCR-F1 0.0036 0.005 0.0029
Loa Loa (eye worm) ctsf protein 0.0455 0.208 0.2894
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0646 0.3002 1
Entamoeba histolytica cysteine protease, putative 0.0194 0.0817 0.3795
Mycobacterium tuberculosis Probable reductase 0.0106 0.0393 0.146
Brugia malayi hypothetical protein 0.0123 0.0471 0.0656
Entamoeba histolytica hypothetical protein 0.0036 0.005 0.0026
Loa Loa (eye worm) hypothetical protein 0.0038 0.0061 0.0085
Leishmania major polypeptide deformylase-like protein, putative 0.0174 0.072 0.2398
Echinococcus granulosus sex peptide receptor 0.0065 0.0194 0.0173
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0042 0.0082 0.0394
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0646 0.3002 1
Brugia malayi hypothetical protein 0.0036 0.005 0.007
Leishmania major oligopeptidase b 0.013 0.0506 0.1685
Leishmania major DNA polymerase eta, putative 0.0036 0.0053 0.0178
Echinococcus multilocularis thioredoxin glutathione reductase 0.0047 0.0104 0.0083
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0363 0.1635 0.2275
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0052 0.0132 0.0183
Plasmodium falciparum histone deacetylase, putative 0.0043 0.0085 0.0406
Entamoeba histolytica cysteine protease, putative 0.0194 0.0817 0.3795
Leishmania major cathepsin L-like protease 0.0455 0.208 0.6928
Plasmodium vivax importin-beta 2, putative 0.0057 0.0155 0.0744
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0103 0.0225
Mycobacterium tuberculosis Probable protease II PtrBb [second part] (oligopeptidase B) 0.013 0.0506 0.203
Leishmania major GTP-binding protein, putative 0.0042 0.0082 0.0273
Schistosoma mansoni neuropeptide receptor 0.0065 0.0194 0.0173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.0817 0.2722
Echinococcus granulosus fmrfamide receptor 0.0065 0.0194 0.0173
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0455 0.208 0.2063
Loa Loa (eye worm) glutathione reductase 0.0047 0.0104 0.0145
Chlamydia trachomatis peptide deformylase 0.0456 0.2084 0.5
Echinococcus multilocularis inhibitor of apoptosis protein 0.0214 0.0914 0.0894
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0065 0.0194 0.0271
Echinococcus granulosus G protein coupled receptor 139 0.0065 0.0194 0.0173
Echinococcus multilocularis neuropeptide receptor 0.0065 0.0194 0.0173
Trypanosoma cruzi major cysteine proteinase, putative 0.0142 0.0564 0.0785
Onchocerca volvulus 0.0034 0.0045 0.0114
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0393 0.146
Brugia malayi MH2 domain containing protein 0.0066 0.0198 0.0276
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Loa Loa (eye worm) RNA binding protein 0.0132 0.0518 0.0721
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0142 0.0564 0.2707
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0146 0.0584 0.1944
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0065 0.0194 0.0271
Brugia malayi prolyl oligopeptidase family protein 0.0055 0.0144 0.02
Trypanosoma cruzi cysteine peptidase, putative 0.0646 0.3002 0.4178
Brugia malayi AKH receptor 0.0065 0.0194 0.0271
Onchocerca volvulus Cathepsin L homolog 0.0455 0.208 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0194 0.0173
Trypanosoma cruzi histone deacetylase, putative 0.0043 0.0085 0.0118
Trypanosoma brucei DNA polymerase IV, putative 0.0117 0.0442 0.1473
Brugia malayi Cathepsin L-like precursor 0.0455 0.208 0.2894
Loa Loa (eye worm) hypothetical protein 0.0123 0.0471 0.0656
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0065 0.0194 0.0173
Trypanosoma cruzi trypanothione reductase, putative 0.0047 0.0104 0.0145
Trypanosoma cruzi DNA polymerase kappa, putative 0.0117 0.0442 0.0615
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0036 0.0053 0.0205
Giardia lamblia Cathepsin B precursor 0.0142 0.0564 0.1995
Entamoeba histolytica dipeptidyl-peptidase, putative 0.0055 0.0144 0.0486
Plasmodium falciparum peptide deformylase 0.0456 0.2084 1
Trypanosoma cruzi histone deacetylase, putative 0.0043 0.0085 0.0118
Echinococcus multilocularis cathepsin L cysteine protease 0.0455 0.208 0.2063
Plasmodium vivax vivapain-1 0.0194 0.0817 0.3922
Echinococcus multilocularis histone deacetylase 7 0.0043 0.0085 0.0063
Toxoplasma gondii HEAT repeat-containing protein 0.0057 0.0155 0.0594
Brugia malayi MH2 domain containing protein 0.0971 0.4572 0.6362
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0646 0.3002 1
Echinococcus granulosus tm gpcr rhodopsin 0.0065 0.0194 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0442 0.1473
Entamoeba histolytica cysteine protease, putative 0.0194 0.0817 0.3795
Trypanosoma cruzi Aminopeptidase M1, putative 0.0034 0.0045 0.0063
Leishmania major importin beta-1 subunit, putative 0.0046 0.0103 0.0342
Giardia lamblia Cathepsin L precursor 0.0142 0.0564 0.1995
Trypanosoma cruzi importin beta-1 subunit, putative 0.0046 0.0103 0.0143
Brugia malayi hypothetical protein 0.0065 0.0194 0.0271
Echinococcus granulosus neuropeptide receptor 0.0065 0.0194 0.0173
Brugia malayi cathepsin B-like cysteine proteinase 0.1512 0.7186 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0065 0.0194 0.0173
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0142 0.0564 0.0544
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0403 0.1827 0.6941
Mycobacterium ulcerans DNA polymerase IV 0.0117 0.0442 0.1948
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0646 0.3002 1
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0117 0.0442 0.1707
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0142 0.0564 0.0785
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0142 0.0564 0.2022
Brugia malayi neuropeptide F receptor 0.0065 0.0194 0.0271
Echinococcus multilocularis snurportin 1 0.0611 0.283 0.2814
Loa Loa (eye worm) cysteine protease 0.0455 0.208 0.2894
Loa Loa (eye worm) hypothetical protein 0.0214 0.0914 0.1272
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Trypanosoma cruzi DNA polymerase eta, putative 0.0117 0.0442 0.0615
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0214 0.0914 0.1272
Entamoeba histolytica hypothetical protein 0.0046 0.0103 0.0284
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0142 0.0564 0.2022
Loa Loa (eye worm) hypothetical protein 0.0142 0.0564 0.0785
Loa Loa (eye worm) Smad1 0.0066 0.0198 0.0276
Echinococcus granulosus 7TM GPCR rhodopsin 0.0065 0.0194 0.0173
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0117 0.0442 0.0615
Echinococcus granulosus importin subunit beta 1 0.0057 0.0155 0.0134
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0146 0.0584 0.0563
Plasmodium falciparum peptidase, putative 0.0055 0.0144 0.0691
Brugia malayi MH1 domain containing protein 0.0037 0.0055 0.0077
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Brugia malayi ORL1-like opioid receptor 0.0065 0.0194 0.0271
Trypanosoma brucei DNA damage repair protein, putative 0.0036 0.0053 0.0178
Echinococcus multilocularis neuropeptide FF receptor 2 0.0065 0.0194 0.0173
Schistosoma mansoni hypothetical protein 0.0611 0.283 0.2814
Loa Loa (eye worm) hypothetical protein 0.0142 0.0564 0.0785
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.0164 0.0143
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0267 0.089
Giardia lamblia Cathepsin B precursor 0.0142 0.0564 0.1995
Trypanosoma brucei C-8 sterol isomerase, putative 0.0363 0.1635 0.5446
Giardia lamblia Alanyl dipeptidyl peptidase 0.0055 0.0144 0.0353
Mycobacterium tuberculosis Conserved hypothetical protein 0.0117 0.0442 0.1707
Leishmania major prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative 0.0284 0.1251 0.4166
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Brugia malayi prolyl oligopeptidase family protein 0.0055 0.0144 0.02
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0194 0.0173
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0566 0.2612 0.87
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0194 0.0817 0.0797
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0455 0.208 0.7927
Echinococcus multilocularis cathepsin b 0.1512 0.7186 0.718
Brugia malayi Dopamine receptor protein 2 0.0065 0.0194 0.0271
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0455 0.208 0.7927
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0164 0.0143
Giardia lamblia Hypothetical protein 0.0142 0.0564 0.1995
Echinococcus granulosus alpha 1A adrenergic receptor 0.0065 0.0194 0.0173
Trypanosoma cruzi Peptide deformylase 2, putative 0.0174 0.072 0.1002
Entamoeba histolytica cysteine protease, putative 0.0194 0.0817 0.3795
Onchocerca volvulus Cathepsin F homolog 0.0455 0.208 1
Echinococcus granulosus tm gpcr rhodopsin 0.0065 0.0194 0.0173
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0142 0.0564 0.255
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Loa Loa (eye worm) neuropeptide F receptor 0.0065 0.0194 0.0271
Toxoplasma gondii thioredoxin reductase 0.0047 0.0104 0.0399
Echinococcus granulosus cathepsin L cysteine proteinase 0.0455 0.208 0.2063
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Leishmania major oligopeptidase B-like protein,serine peptidase, clan SC, family S9A-like protein 0.013 0.0506 0.1685
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0065 0.0194 0.0173
Giardia lamblia DINP protein human, muc B family 0.0117 0.0442 0.1519
Schistosoma mansoni hypothetical protein 0.0065 0.0194 0.0173
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Trypanosoma brucei histone deacetylase 3 0.0043 0.0085 0.0282
Toxoplasma gondii cathepsin CPL 0.0455 0.208 0.7963
Plasmodium falciparum importin beta, putative 0.0057 0.0155 0.0744
Brugia malayi G-protein coupled receptor 0.0065 0.0194 0.0271
Leishmania major C-8 sterol isomerase-like protein 0.0363 0.1635 0.5446
Schistosoma mansoni histone deacetylase 4 5 0.0043 0.0085 0.0063
Toxoplasma gondii histone deacetylase HDAC1 0.0043 0.0085 0.0324
Trypanosoma cruzi DNA polymerase eta, putative 0.0036 0.0053 0.0074
Entamoeba histolytica cysteine protease, putative 0.0194 0.0817 0.3795
Entamoeba histolytica Ran family GTPase 0.0042 0.0082 0.0182
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Loa Loa (eye worm) MH2 domain-containing protein 0.0971 0.4572 0.6362
Schistosoma mansoni bromodomain containing protein 0.0062 0.0179 0.0158
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0455 0.208 0.7927
Echinococcus multilocularis cathepsin L cysteine protease 0.0455 0.208 0.2063
Brugia malayi TAR-binding protein 0.0132 0.0518 0.0721
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1512 0.7186 0.718
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0442 0.1473
Onchocerca volvulus Cell death protein 3 homolog 0.0123 0.0471 0.2185
Leishmania major cathepsin L-like protease 0.0646 0.3002 1
Giardia lamblia Cathepsin L-like protease 0.0142 0.0564 0.1995
Entamoeba histolytica cysteine proteinase, putative 0.0194 0.0817 0.3795
Echinococcus granulosus mothers against decapentaplegic 5 0.0066 0.0198 0.0177
Plasmodium falciparum cysteine proteinase falcipain 3 0.0455 0.208 0.9982
Onchocerca volvulus 0.0455 0.208 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0442 0.1473
Toxoplasma gondii cathepsin B 0.0566 0.2612 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0455 0.208 0.7927
Onchocerca volvulus Prolyl endopeptidase homolog 0.0284 0.1251 0.5972
Leishmania major cathepsin L-like protease 0.0455 0.208 0.6928
Plasmodium vivax unspecified product 0.0142 0.0564 0.2707
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0146 0.0584 0.2234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0646 0.3002 1
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Entamoeba histolytica cysteine protease, putative 0.0194 0.0817 0.3795
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0065 0.0194 0.0173
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0239 0.1031 0.1012
Onchocerca volvulus 0.0065 0.0194 0.084
Echinococcus granulosus neuropeptide receptor 0.0065 0.0194 0.0173
Brugia malayi G protein-coupled receptor F59B2.13 0.0065 0.0194 0.0271
Onchocerca volvulus 0.0065 0.0194 0.084
Onchocerca volvulus 0.0065 0.0194 0.084
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.0164 0.0304
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0045 0.0024
Mycobacterium ulcerans peptide deformylase 0.0456 0.2084 1
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.0381 0.1719 0.8248
Schistosoma mansoni cathepsin C 0.0142 0.0564 0.0544
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0085 0.0063
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0142 0.0564 0.255
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0455 0.208 0.7927
Brugia malayi Cathepsin L-like precursor 0.0403 0.1827 0.2542
Schistosoma mansoni smad1 5 8 and 0.0066 0.0198 0.0177
Echinococcus multilocularis cathepsin b 0.1512 0.7186 0.718
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0065 0.0194 0.0271
Trypanosoma brucei Peptide deformylase 2 0.0174 0.072 0.2398
Echinococcus granulosus tar DNA binding protein 0.0132 0.0518 0.0498
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0065 0.0194 0.0173
Brugia malayi Histone deacetylase family protein 0.0043 0.0085 0.0118
Trypanosoma brucei histone deacetylase 4 0.0043 0.0085 0.0282
Mycobacterium tuberculosis Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) 0.0456 0.2084 1
Entamoeba histolytica cysteine protease, putative 0.0194 0.0817 0.3795
Trypanosoma cruzi aminopeptidase, putative 0.0034 0.0045 0.0063
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0049 0.0028
Loa Loa (eye worm) transcription factor SMAD2 0.0971 0.4572 0.6362
Loa Loa (eye worm) hypothetical protein 0.0214 0.0914 0.1272
Leishmania major DNA polymerase kappa, putative 0.0117 0.0442 0.1473
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0164 0.0586
Trypanosoma cruzi cysteine protease, putative 0.0194 0.0817 0.1137
Schistosoma mansoni biogenic amine (5HT) receptor 0.0065 0.0194 0.0173
Schistosoma mansoni cathepsin F (C01 family) 0.0403 0.1827 0.1809
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0142 0.0564 0.1995
Brugia malayi hypothetical protein 0.0065 0.0194 0.0271
Schistosoma mansoni biogenic amine receptor 0.0065 0.0194 0.0173
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0065 0.0194 0.0173
Echinococcus granulosus orexin receptor type 2 0.0065 0.0194 0.0173
Onchocerca volvulus 0.0065 0.0194 0.084
Echinococcus granulosus prolyl endopeptidase 0.0284 0.1251 0.1232
Entamoeba histolytica cysteine proteinase, putative 0.0455 0.208 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0155 0.0516
Plasmodium vivax vivapain-3 0.0194 0.0817 0.3922
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Echinococcus multilocularis serotonin receptor 0.0065 0.0194 0.0173
Brugia malayi cathepsin L-like cysteine proteinase 0.0142 0.0564 0.0785
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0455 0.208 0.7927
Trypanosoma brucei Aminopeptidase M1, putative 0.0034 0.0045 0.015
Echinococcus granulosus 7tm_1 domain containing protein 0.0065 0.0194 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0053 0.0178
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0393 0.146
Trypanosoma cruzi DNA damage repair protein, putative 0.0036 0.0053 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0442 0.1473
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0117 0.0442 0.1547
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Wolbachia endosymbiont of Brugia malayi peptide deformylase 0.0456 0.2084 0.5
Giardia lamblia Cathepsin L precursor 0.0142 0.0564 0.1995
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0065 0.0194 0.0173
Brugia malayi Melatonin receptor type 1A 0.0065 0.0194 0.0271
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0045 0.0024
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0146 0.0584 0.0812
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0393 0.146
Giardia lamblia Cathepsin L precursor 0.0142 0.0564 0.1995
Mycobacterium tuberculosis Probable protease II PtrBa [first part] (oligopeptidase B) 0.0229 0.0986 0.4452
Trypanosoma cruzi cysteine peptidase, putative 0.0646 0.3002 0.4178
Brugia malayi Peptidase family M1 containing protein 0.0034 0.0045 0.0063
Leishmania major histone deacetylase, putative 0.0043 0.0085 0.0282
Giardia lamblia Cathepsin L precursor 0.0142 0.0564 0.1995
Trypanosoma brucei trypanothione reductase 0.0047 0.0104 0.0347
Brugia malayi Cathepsin L-like precursor 0.0455 0.208 0.2894
Echinococcus multilocularis g-protein coupled receptor 0.0065 0.0194 0.0173
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0117 0.0442 0.0422
Echinococcus granulosus cathepsin L 0.0194 0.0817 0.0797
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0059 0.0162 0.0141
Plasmodium falciparum serine repeat antigen 6 0.0142 0.0564 0.2707
Loa Loa (eye worm) MH2 domain-containing protein 0.003 0.0022 0.003
Trypanosoma cruzi cysteine peptidase, putative 0.0455 0.208 0.2894
Plasmodium falciparum serine repeat antigen 4 0.0142 0.0564 0.2707
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0174 0.072 0.1002
Onchocerca volvulus 0.0455 0.208 1
Entamoeba histolytica cysteine proteinase, putative 0.0194 0.0817 0.3795
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0065 0.0194 0.0173
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0194 0.0173
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0045 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0142 0.0564 0.2022
Entamoeba histolytica cysteine proteinase 2 0.0194 0.0817 0.3795
Brugia malayi G protein-coupled receptor 0.0065 0.0194 0.0271
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0034 0.0045 0.0024
Brugia malayi Cathepsin L-like precursor 0.0455 0.208 0.2894
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0065 0.0194 0.0173
Brugia malayi Cathepsin L-like precursor 0.0455 0.208 0.2894
Entamoeba histolytica cysteine protease, putative 0.0194 0.0817 0.3795
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0594 0.2749 0.3825
Echinococcus multilocularis neuropeptides capa receptor 0.0065 0.0194 0.0173
Treponema pallidum polypeptide deformylase (def) 0.0456 0.2084 0.5
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0393 0.146
Loa Loa (eye worm) neuropeptide F receptor 0.0065 0.0194 0.0271
Echinococcus granulosus Smad4 0.0066 0.0198 0.0177
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0142 0.0564 0.2707
Schistosoma mansoni amine GPCR 0.0065 0.0194 0.0173
Echinococcus granulosus aminopeptidase N 0.0034 0.0045 0.0024
Loa Loa (eye worm) hypothetical protein 0.0284 0.1251 0.1741
Loa Loa (eye worm) MH1 domain-containing protein 0.003 0.0022 0.003
Giardia lamblia Alanyl dipeptidyl peptidase 0.0055 0.0144 0.0353
Brugia malayi Papain family cysteine protease containing protein 0.0142 0.0564 0.0785
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0393 0.146
Onchocerca volvulus Cathepsin L homolog 0.0455 0.208 1
Entamoeba histolytica hypothetical protein 0.0036 0.005 0.0026
Mycobacterium leprae PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) 0.0456 0.2084 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Echinococcus granulosus somatostatin receptor 0.0065 0.0194 0.0173
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Loa Loa (eye worm) aminopeptidase N 0.0034 0.0045 0.0063
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0055 0.0144 0.0123
Echinococcus granulosus GTP binding nuclear protein Ran 0.0042 0.0082 0.0061
Echinococcus granulosus baculoviral IAP repeat containing protein 0.0214 0.0914 0.0894
Onchocerca volvulus 0.0065 0.0194 0.084
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0042 0.0082 0.0112
Loa Loa (eye worm) hypothetical protein 0.0142 0.0564 0.0785
Onchocerca volvulus 0.0065 0.0194 0.084
Mycobacterium ulcerans protease II (oligopeptidase B), PtrB 0.013 0.0506 0.2261
Entamoeba histolytica cysteine protease, putative 0.0194 0.0817 0.3795
Schistosoma mansoni neuropeptide f receptor 76f 0.0065 0.0194 0.0173
Giardia lamblia Cathepsin B precursor 0.0566 0.2612 1
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0455 0.208 0.2894
Trypanosoma cruzi histone deacetylase, putative 0.0043 0.0085 0.0118
Trichomonas vaginalis conserved hypothetical protein 0.0055 0.0144 0.0385
Plasmodium vivax glutathione reductase, putative 0.0047 0.0104 0.05
Trypanosoma brucei unspecified product 0.008 0.0267 0.089
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0239 0.1031 0.1435
Echinococcus granulosus hypothetical protein 0.0065 0.0194 0.0173
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0085 0.0063
Echinococcus granulosus histone deacetylase 6 0.0043 0.0085 0.0063
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0065 0.0194 0.0271
Mycobacterium tuberculosis Probable peptidase 0.013 0.0506 0.203
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Leishmania major histone deacetylase, putative 0.0043 0.0085 0.0282
Trypanosoma brucei Alpha/beta hydrolase domain-containing protein 0.0055 0.0144 0.0479
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Trypanosoma brucei DNA polymerase eta, putative 0.0117 0.0442 0.1473
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0183
Schistosoma mansoni DNA polymerase IV / kappa 0.0036 0.0053 0.0032
Onchocerca volvulus 0.0065 0.0194 0.084
Loa Loa (eye worm) prolyl oligopeptidase 0.0055 0.0144 0.02
Plasmodium falciparum serine repeat antigen 8 0.0142 0.0564 0.2707
Trypanosoma brucei prolyl endopeptidase 0.0284 0.1251 0.4166
Loa Loa (eye worm) hypothetical protein 0.0057 0.0155 0.0216
Loa Loa (eye worm) TAR-binding protein 0.0132 0.0518 0.0721
Echinococcus granulosus smad 0.0066 0.0198 0.0177
Brugia malayi Cathepsin L-like cysteine proteinase 0.0403 0.1827 0.2542
Schistosoma mansoni opsin-like receptor 0.0065 0.0194 0.0173
Leishmania major cathepsin L-like protease 0.0455 0.208 0.6928
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.0451 0.175
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0142 0.0564 0.0785
Brugia malayi hypothetical protein 0.0091 0.0318 0.0443
Loa Loa (eye worm) hypothetical protein 0.004 0.0072 0.01
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0442 0.1473
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0053 0.0178
Echinococcus granulosus cathepsin l1 0.0403 0.1827 0.1809
Schistosoma mansoni hypothetical protein 0.0214 0.0914 0.0894
Trypanosoma cruzi oligopeptidase b 0.013 0.0506 0.0704
Brugia malayi Bromodomain containing protein 0.0038 0.0061 0.0084
Entamoeba histolytica cysteine protease, putative 0.0455 0.208 1
Onchocerca volvulus 0.0065 0.0194 0.084
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Plasmodium vivax peptide deformylase, putative 0.0456 0.2084 1
Trypanosoma brucei unspecified product 0.0117 0.0442 0.1473
Trypanosoma cruzi cysteine peptidase, putative 0.0194 0.0817 0.1137
Leishmania major DNA polymerase kappa, putative 0.0036 0.0053 0.0178
Echinococcus granulosus cathepsin L 0.0142 0.0564 0.0544
Trypanosoma cruzi prolyl endopeptidase 0.0284 0.1251 0.1741
Onchocerca volvulus 0.0065 0.0194 0.084
Echinococcus granulosus histone deacetylase 6 0.0043 0.0085 0.0063
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.0381 0.1719 0.1702
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0239 0.1031 0.1012
Giardia lamblia Cysteine protease 0.0142 0.0564 0.1995
Entamoeba histolytica deoxycytidyl transferase, putative 0.0117 0.0442 0.1951
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0034 0.0045 0.0024
Toxoplasma gondii preprocathepsin c precursor, putative 0.0142 0.0564 0.2159
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0817 0.3008
Echinococcus multilocularis tar DNA binding protein 0.0132 0.0518 0.0498
Echinococcus multilocularis apoptotic protease activating factor 1 0.0123 0.0471 0.0451
Schistosoma mansoni neuropeptide receptor 0.0065 0.0194 0.0173
Schistosoma mansoni smad 0.0066 0.0198 0.0177
Brugia malayi Inhibitor of Apoptosis domain containing protein 0.0214 0.0914 0.1272
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0082 0.0114
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0142 0.0564 0.0785
Loa Loa (eye worm) hypothetical protein 0.0091 0.0318 0.0443
Leishmania major trypanothione reductase 0.0047 0.0104 0.0347
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0065 0.0194 0.0173
Leishmania major DNA polymerase eta, putative 0.0117 0.0442 0.1473
Trypanosoma cruzi DNA polymerase kappa, putative 0.0117 0.0442 0.0615
Plasmodium falciparum cysteine proteinase falcipain 1 0.0194 0.0817 0.3922
Onchocerca volvulus 0.0455 0.208 1
Brugia malayi cathepsin L-like precursor 0.0403 0.1827 0.2542
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0065 0.0194 0.0271
Schistosoma mansoni adenoreceptor 0.0065 0.0194 0.0173
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0566 0.2612 0.3635
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0065 0.0194 0.0173
Loa Loa (eye worm) G-protein coupled receptor 0.0065 0.0194 0.0271
Brugia malayi hypothetical protein 0.0065 0.0194 0.0271
Plasmodium vivax histone deacetylase, putative 0.0043 0.0085 0.0406
Echinococcus multilocularis cysteine protease 0.0455 0.208 0.2063
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.1512 0.7186 0.718
Plasmodium falciparum DNA repair protein REV1, putative 0.0036 0.0053 0.0257
Brugia malayi ImpB/MucB/SamB family protein 0.0117 0.0442 0.0615
Giardia lamblia Cathepsin L precursor 0.0142 0.0564 0.1995
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0455 0.208 0.2063
Echinococcus granulosus Dipeptidyl peptidase 9 0.0146 0.0584 0.0563
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0194 0.0817 0.0797
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0646 0.3002 1
Giardia lamblia Cysteine protease 0.0142 0.0564 0.1995
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0142 0.0564 0.2707
Trichomonas vaginalis Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase 0.0055 0.0144 0.0385
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0183
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0045 0.0024
Onchocerca volvulus 0.0403 0.1827 0.877
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0518 0.0498
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0194 0.0173
Trypanosoma cruzi oligopeptidase B-like protein, putative 0.013 0.0506 0.0704
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Brugia malayi GnHR receptor homolog 0.0065 0.0194 0.0271
Loa Loa (eye worm) hypothetical protein 0.0052 0.0132 0.0183
Onchocerca volvulus 0.0455 0.208 1
Echinococcus multilocularis g protein coupled receptor 0.0065 0.0194 0.0173
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0065 0.0194 0.0173
Onchocerca volvulus Cathepsin L homolog 0.0142 0.0564 0.2635
Onchocerca volvulus 0.0034 0.0045 0.0114
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.0451 0.034
Plasmodium falciparum histone deacetylase 2 0.0043 0.0085 0.0406
Plasmodium falciparum serine repeat antigen 7 0.0142 0.0564 0.2707
Brugia malayi cathepsin Z-like cysteine proteinase 0.0142 0.0564 0.0785
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Toxoplasma gondii acylaminoacyl-peptidase, putative 0.0055 0.0144 0.0551
Trypanosoma cruzi cysteine peptidase, putative 0.0646 0.3002 0.4178
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0442 0.1473
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0065 0.0194 0.0271
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0194 0.0173
Entamoeba histolytica hypothetical protein 0.0036 0.005 0.0026
Schistosoma mansoni amine GPCR 0.0065 0.0194 0.0173
Trypanosoma brucei DNA polymerase IV, putative 0.0117 0.0442 0.1473
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0142 0.0564 0.2707
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Brugia malayi MH1 domain containing protein 0.0037 0.0055 0.0077
Onchocerca volvulus 0.0065 0.0194 0.084
Brugia malayi Papain family cysteine protease containing protein 0.0142 0.0564 0.0785
Schistosoma mansoni ran 0.0042 0.0082 0.0061
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0065 0.0194 0.0173
Echinococcus multilocularis acylamino acid releasing enzyme 0.0055 0.0144 0.0123
Echinococcus granulosus tachykinin peptides receptor 99D 0.0065 0.0194 0.0173
Loa Loa (eye worm) hypothetical protein 0.0363 0.1635 0.2275
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0042 0.0082 0.0394
Trypanosoma cruzi DNA polymerase kappa, putative 0.0117 0.0442 0.0615
Giardia lamblia Cathepsin B precursor 0.0142 0.0564 0.1995
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0065 0.0194 0.0271
Plasmodium vivax hypothetical protein, conserved 0.0055 0.0144 0.0691
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0144 0.02
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0034 0.0045 0.015
Echinococcus multilocularis histone deacetylase 6 0.0043 0.0085 0.0063
Leishmania major cysteine peptidase A (CPA) 0.0455 0.208 0.6928
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0042 0.0082 0.0114
Schistosoma mansoni neuropeptide receptor 0.0065 0.0194 0.0173
Brugia malayi MH2 domain containing protein 0.003 0.0022 0.003
Echinococcus granulosus histone deacetylase 7 0.0043 0.0085 0.0063
Echinococcus granulosus peptide allatostatin:somatostatin 0.0065 0.0194 0.0173
Trypanosoma brucei DNA polymerase kappa, putative 0.008 0.0267 0.089
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0146 0.0584 0.0812
Trypanosoma brucei DNA polymerase kappa, putative 0.0036 0.0053 0.0178
Brugia malayi Cell death protein 3 precursor 0.0123 0.0471 0.0656
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0142 0.0564 0.2022
Trypanosoma brucei importin beta-1 subunit, putative 0.0057 0.0155 0.0516
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0065 0.0194 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0142 0.0564 0.2022
Loa Loa (eye worm) cathepsin B 0.0566 0.2612 0.3635
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0142 0.0564 0.2022
Trichomonas vaginalis conserved hypothetical protein 0.0142 0.0564 0.2022
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0065 0.0194 0.0173
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0142 0.0564 0.2022
Schistosoma mansoni opsin-like receptor 0.0065 0.0194 0.0173
Trichomonas vaginalis DNA polymerase eta, putative 0.0117 0.0442 0.1547
Plasmodium falciparum serine repeat antigen 1 0.0142 0.0564 0.2707
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0146 0.0584 0.1944
Schistosoma mansoni hypothetical protein 0.0123 0.0471 0.0451
Brugia malayi Serotonin receptor 0.0065 0.0194 0.0271
Schistosoma mansoni neuropeptide receptor 0.0065 0.0194 0.0173
Brugia malayi Importin beta-1 subunit 0.0057 0.0155 0.0216
Brugia malayi Papain family cysteine protease containing protein 0.0194 0.0817 0.1137
Brugia malayi Smad1 0.0066 0.0198 0.0276
Echinococcus multilocularis Smad4 0.0066 0.0198 0.0177
Brugia malayi Dopamine receptor protein 1 0.0065 0.0194 0.0271
Echinococcus granulosus histone deacetylase 0.0043 0.0085 0.0063
Entamoeba histolytica cysteine protease, putative 0.0142 0.0564 0.255
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Plasmodium falciparum serine repeat antigen 2 0.0142 0.0564 0.2707
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Schistosoma mansoni cathepsin B (C01 family) 0.0142 0.0564 0.0544
Echinococcus multilocularis G protein coupled receptor 139 0.0065 0.0194 0.0173
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0142 0.0564 0.2707
Echinococcus multilocularis caspase 2 0.0123 0.0471 0.0451
Echinococcus multilocularis neuropeptide s receptor 0.0065 0.0194 0.0173
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0045 0.0024
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Plasmodium vivax serine-repeat antigen (SERA) 0.0142 0.0564 0.2707
Echinococcus multilocularis importin subunit beta 1 0.0057 0.0155 0.0134
Trypanosoma cruzi polypeptide deformylase-like protein, putative 0.0174 0.072 0.1002
Echinococcus multilocularis G-protein coupled receptor, putative 0.0065 0.0194 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0455 0.208 0.7927
Brugia malayi cathepsin F-like cysteine proteinase 0.0142 0.0564 0.0785
Schistosoma mansoni amine GPCR 0.0065 0.0194 0.0173
Brugia malayi hypothetical protein 0.0065 0.0194 0.0271
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0117 0.0442 0.0422
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0142 0.0564 0.2707
Loa Loa (eye worm) hypothetical protein 0.0043 0.0085 0.0118
Echinococcus multilocularis dna polymerase eta 0.0117 0.0442 0.0422
Loa Loa (eye worm) hypothetical protein 0.007 0.0215 0.0299
Echinococcus granulosus TGF beta signal transducer SmadC 0.0066 0.0198 0.0177
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.0164 0.0143
Giardia lamblia Cysteine protease 0.0142 0.0564 0.1995
Loa Loa (eye worm) hypothetical protein 0.0117 0.0442 0.0615
Giardia lamblia Encystation-specific protease 0.0142 0.0564 0.1995
Echinococcus multilocularis neuropeptide Y receptor 0.0065 0.0194 0.0173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0646 0.3002 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0065 0.0194 0.0271
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Echinococcus granulosus serotonin receptor 0.0065 0.0194 0.0173
Entamoeba histolytica cysteine proteinase, putative 0.0194 0.0817 0.3795
Echinococcus granulosus acylamino acid releasing enzyme 0.0055 0.0144 0.0123
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Schistosoma mansoni inhibitor of apoptosis (iap) domain family member 0.0214 0.0914 0.0894
Echinococcus multilocularis fmrfamide receptor 0.0065 0.0194 0.0173
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0284 0.1251 0.1232
Onchocerca volvulus 0.0065 0.0194 0.084
Brugia malayi hypothetical protein 0.0034 0.0045 0.0063
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Brugia malayi Bromodomain containing protein 0.0074 0.0235 0.0327
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0142 0.0564 0.2022
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0059 0.0162 0.0141
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0053 0.0178
Echinococcus multilocularis allatostatin A receptor 0.0065 0.0194 0.0173
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0142 0.0564 0.0544
Schistosoma mansoni histone deacetylase hda2 0.0043 0.0085 0.0063
Echinococcus multilocularis somatostatin receptor 0.0065 0.0194 0.0173
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0194 0.0173
Echinococcus granulosus neuropeptide Y receptor 0.0065 0.0194 0.0173
Plasmodium vivax serine-repeat antigen (SERA) 0.0142 0.0564 0.2707
Schistosoma mansoni ran 0.0042 0.0082 0.0061
Brugia malayi Papain family cysteine protease containing protein 0.0194 0.0817 0.1137
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0239 0.1031 0.1012
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0065 0.0194 0.0173
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0065 0.0194 0.0173
Schistosoma mansoni biogenic amine receptor 0.0065 0.0194 0.0173
Schistosoma mansoni importin beta-1 0.0057 0.0155 0.0134
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0142 0.0564 0.2707
Echinococcus granulosus dna polymerase kappa 0.0117 0.0442 0.0422
Brugia malayi hypothetical protein 0.0065 0.0194 0.0271
Schistosoma mansoni acylaminoacyl-peptidase (S09 family) 0.0055 0.0144 0.0123
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0042 0.0082 0.0114
Echinococcus multilocularis orexin receptor type 2 0.0065 0.0194 0.0173
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Entamoeba histolytica cysteine proteinase 1, putative 0.0194 0.0817 0.3795
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0403 0.1827 0.6941
Schistosoma mansoni inhibitor of apoptosis protein 0.0214 0.0914 0.0894
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0142 0.0564 0.2707
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0046 0.0103 0.0225
Brugia malayi ImpB/MucB/SamB family protein 0.0117 0.0442 0.0615
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0065 0.0194 0.0173
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.0164 0.0143
Loa Loa (eye worm) hypothetical protein 0.0055 0.0144 0.02
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0117 0.0442 0.0422
Plasmodium vivax thioredoxin reductase, putative 0.0047 0.0104 0.05
Schistosoma mansoni hypothetical protein 0.2094 1 1
Plasmodium falciparum glutathione reductase 0.0047 0.0104 0.05
Mycobacterium leprae PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) 0.013 0.0506 0.0668
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Loa Loa (eye worm) hypothetical protein 0.0055 0.0144 0.02
Brugia malayi larval opioid receptor 0.0065 0.0194 0.0271
Brugia malayi Cathepsin L-like precursor 0.0052 0.0132 0.0183
Leishmania major cathepsin L-like protease 0.0646 0.3002 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Giardia lamblia Cathepsin B precursor 0.0566 0.2612 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0065 0.0194 0.0173
Entamoeba histolytica cysteine protease, putative 0.0142 0.0564 0.255
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.0164 0.0629
Echinococcus granulosus inhibitor of apoptosis protein 0.0214 0.0914 0.0894
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0164 0.0586
Echinococcus multilocularis mothers against decapentaplegic 5 0.0066 0.0198 0.0177
Giardia lamblia Cysteine protease 0.0142 0.0564 0.1995
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0455 0.208 0.7927
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0142 0.0564 0.2022
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0566 0.2612 0.2596
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Echinococcus multilocularis smad 0.0066 0.0198 0.0177
Onchocerca volvulus 0.0455 0.208 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0065 0.0194 0.0173
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0363 0.1635 0.2275
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0142 0.0564 0.2022
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0039 0.0069 0.0048
Schistosoma mansoni smad1 5 8 and 0.0066 0.0198 0.0177
Schistosoma mansoni DNA polymerase eta 0.0117 0.0442 0.0422
Brugia malayi MH1 domain containing protein 0.0066 0.0198 0.0276
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0065 0.0194 0.0173
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Echinococcus granulosus cathepsin l1 0.0455 0.208 0.2063
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0142 0.0564 0.2707
Brugia malayi neuropeptide F receptor 0.0065 0.0194 0.0271
Brugia malayi prolyl oligopeptidase family protein 0.0284 0.1251 0.1741
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Schistosoma mansoni myosin xvIII 0.0065 0.0194 0.0173
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0065 0.0194 0.0173
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0239 0.1031 0.1435
Loa Loa (eye worm) hypothetical protein 0.0142 0.0564 0.0785
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0053 0.0074
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0646 0.3002 1
Echinococcus multilocularis neuropeptide Y receptor 0.0065 0.0194 0.0173
Giardia lamblia Cathepsin L-like protease 0.0142 0.0564 0.1995
Trypanosoma cruzi DNA damage repair protein, putative 0.0036 0.0053 0.0074
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0442 0.1473
Trichomonas vaginalis importin beta-1, putative 0.0046 0.0103 0.0225
Entamoeba histolytica hypothetical protein 0.0036 0.005 0.0026
Echinococcus multilocularis prolyl endopeptidase 0.0284 0.1251 0.1232
Plasmodium vivax histone deacetylase 2, putative 0.0043 0.0085 0.0406
Brugia malayi Peptidase family M1 containing protein 0.0034 0.0045 0.0063
Entamoeba histolytica cysteine protease, putative 0.0194 0.0817 0.3795
Trypanosoma brucei histone deacetylase, putative 0.0043 0.0085 0.0282
Loa Loa (eye worm) fibroinase 0.0455 0.208 0.2894
Brugia malayi RNA binding protein 0.0132 0.0518 0.0721
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0239 0.1031 0.1012
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0142 0.0564 0.2707
Entamoeba histolytica cysteine protease, putative 0.0142 0.0564 0.255
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Echinococcus multilocularis cathepsin L 0.0194 0.0817 0.0797
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0442 0.1473
Echinococcus granulosus cathepsin l cysteine peptidase 0.0455 0.208 0.2063
Loa Loa (eye worm) hypothetical protein 0.003 0.0022 0.003
Loa Loa (eye worm) hypothetical protein 0.0042 0.0081 0.0113
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0142 0.0564 0.2022
Entamoeba histolytica cysteine protease, putative 0.0142 0.0564 0.255
Brugia malayi prolyl oligopeptidase family protein 0.0146 0.0584 0.0812
Trypanosoma brucei Aminopeptidase M1, putative 0.0034 0.0045 0.015
Brugia malayi MH2 domain containing protein 0.0066 0.0198 0.0276
Schistosoma mansoni biogenic amine receptor 0.0065 0.0194 0.0173
Brugia malayi Dopamine receptor 0.0065 0.0194 0.0271
Echinococcus multilocularis cysteine protease 0.0455 0.208 0.2063
Schistosoma mansoni smad1 5 8 and 0.0066 0.0198 0.0177
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.0381 0.1719 0.1702
Echinococcus multilocularis neuropeptides capa receptor 0.0065 0.0194 0.0173
Onchocerca volvulus 0.0065 0.0194 0.084
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0142 0.0564 0.0544
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0611 0.283 0.3938
Echinococcus granulosus dro:myosuppressin receptor 0.0065 0.0194 0.0173
Plasmodium vivax unspecified product 0.0052 0.0132 0.0632
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0066 0.0198 0.0177
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0042 0.0082 0.0314
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.0164 0.0586
Onchocerca volvulus Neuropeptide F receptor homolog 0.0065 0.0194 0.084
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0049 0.0028
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0194 0.0817 0.0797
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0142 0.0564 0.2707
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0132 0.0518 0.0721
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0455 0.208 0.7927
Brugia malayi Cathepsin L-like precursor 0.0403 0.1827 0.2542
Echinococcus granulosus g protein coupled receptor 0.0065 0.0194 0.0173
Trypanosoma cruzi cysteine peptidase, putative 0.0052 0.0132 0.0183
Echinococcus multilocularis fmrfamide receptor 0.0065 0.0194 0.0173
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0042 0.0082 0.0061
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0065 0.0194 0.0173
Loa Loa (eye worm) hypothetical protein 0.0142 0.0564 0.0785
Brugia malayi glutathione reductase 0.0047 0.0104 0.0145
Giardia lamblia Cathepsin L precursor 0.0142 0.0564 0.1995
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0455 0.208 0.2894
Entamoeba histolytica cysteine protease, putative 0.0194 0.0817 0.3795
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1512 0.7186 0.718
Schistosoma mansoni cathepsin F (C01 family) 0.0455 0.208 0.2063
Entamoeba histolytica hypothetical protein, conserved 0.0055 0.0144 0.0486
Trypanosoma cruzi major cysteine proteinase, putative 0.0333 0.1486 0.2068
Brugia malayi polk-prov protein 0.0036 0.0053 0.0074
Loa Loa (eye worm) TYRA-2 protein 0.0065 0.0194 0.0271
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0034 0.0045 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0142 0.0564 0.2022
Giardia lamblia Hypothetical protein 0.0142 0.0564 0.1995
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Leishmania major DNA damage repair protein, putative 0.0036 0.0053 0.0178
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0065 0.0194 0.0173
Brugia malayi follicle stimulating hormone receptor 0.0065 0.0194 0.0271
Loa Loa (eye worm) melatonin receptor type 1A 0.0065 0.0194 0.0271
Onchocerca volvulus 0.0123 0.0471 0.2185
Schistosoma mansoni amine GPCR 0.0065 0.0194 0.0173
Loa Loa (eye worm) hypothetical protein 0.1512 0.7186 1
Trypanosoma cruzi cysteine proteinase, putative 0.0194 0.0817 0.1137
Schistosoma mansoni amine GPCR 0.0065 0.0194 0.0173
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0239 0.1031 0.1012
Toxoplasma gondii prolyl endopeptidase 0.0284 0.1251 0.4789
Onchocerca volvulus 0.0214 0.0914 0.4335
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0142 0.0564 0.1995
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Brugia malayi cathepsin Z-like cysteine proteinase 0.0142 0.0564 0.0785
Trypanosoma brucei Polypeptide deformylase 1 0.0174 0.072 0.2398
Trypanosoma cruzi hypothetical protein, conserved 0.0055 0.0144 0.02
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Brugia malayi hypothetical protein 0.0065 0.0194 0.0271
Loa Loa (eye worm) hypothetical protein 0.0186 0.0776 0.108
Brugia malayi fibroinase precursor 0.0142 0.0564 0.0785
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0142 0.0564 0.0544
Brugia malayi Cathepsin L-like precursor 0.0455 0.208 0.2894
Brugia malayi hypothetical protein 0.0065 0.0194 0.0271
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0034 0.0045 0.015
Echinococcus granulosus histone deacetylase 6 0.0043 0.0085 0.0063
Trypanosoma brucei cysteine peptidase C (CPC) 0.0566 0.2612 0.87
Trypanosoma cruzi DNA polymerase kappa, putative 0.0117 0.0442 0.0615
Brugia malayi G-protein coupled receptor 0.0065 0.0194 0.0271
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0518 0.0498
Trypanosoma cruzi serine peptidase, clan SC, family S9A-like protein, putative 0.013 0.0506 0.0704
Brugia malayi RNA, U transporter 1 0.0163 0.0665 0.0925
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0065 0.0194 0.0173
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Trypanosoma brucei DNA polymerase kappa, putative 0.0117 0.0442 0.1473
Echinococcus multilocularis g protein coupled receptor 0.0065 0.0194 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0142 0.0564 0.2022
Leishmania major cathepsin L-like protease 0.0646 0.3002 1
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.0381 0.1719 0.1702
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0065 0.0194 0.0173
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.0451 0.175
Echinococcus multilocularis serotonin receptor 0.0065 0.0194 0.0173
Brugia malayi sulfakinin receptor protein 0.0065 0.0194 0.0271
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0142 0.0564 0.0544
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0142 0.0564 0.2022
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.1512 0.7186 0.718
Echinococcus granulosus tm gpcr rhodopsin 0.0065 0.0194 0.0173
Echinococcus multilocularis neuropeptide receptor A26 0.0065 0.0194 0.0173
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0142 0.0564 0.1995
Trypanosoma cruzi oligopeptidase b 0.013 0.0506 0.0704
Brugia malayi Papain family cysteine protease containing protein 0.0455 0.208 0.2894
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0065 0.0194 0.0271
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0142 0.0564 0.2707
Onchocerca volvulus 0.0455 0.208 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0065 0.0194 0.084
Giardia lamblia Cathepsin B precursor 0.0142 0.0564 0.1995
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0142 0.0564 0.2022
Toxoplasma gondii cathepsin CPC1 0.0142 0.0564 0.2159
Echinococcus multilocularis dro:myosuppressin receptor 0.0065 0.0194 0.0173
Plasmodium vivax unspecified product 0.0194 0.0817 0.3922
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.0164 0.0548
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0065 0.0194 0.0173
Trichomonas vaginalis conserved hypothetical protein 0.0142 0.0564 0.2022
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0034 0.0045 0.0063
Trypanosoma brucei oligopeptidase b 0.013 0.0506 0.1685
Entamoeba histolytica prolyl oligopeptidase family protein 0.0055 0.0144 0.0486
Schistosoma mansoni cathepsin F (C01 family) 0.0455 0.208 0.2063
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0052 0.0132 0.0183
Echinococcus multilocularis g protein coupled receptor 0.0065 0.0194 0.0173
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0053 0.0074
Trypanosoma brucei unspecified product 0.008 0.0267 0.089
Schistosoma mansoni growth hormone secretagogue receptor 0.0065 0.0194 0.0173
Echinococcus granulosus biogenic amine 5HT receptor 0.0065 0.0194 0.0173
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0566 0.2612 1
Plasmodium vivax vivapain-2 0.0455 0.208 0.9982
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0065 0.0194 0.0271
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0455 0.208 0.9982
Entamoeba histolytica cysteine proteinase, putative 0.0455 0.208 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0455 0.208 0.7927
Toxoplasma gondii hypothetical protein 0.0055 0.0144 0.0551
Schistosoma mansoni biogenic amine (5HT) receptor 0.0065 0.0194 0.0173
Brugia malayi Histone deacetylase family protein 0.0043 0.0085 0.0118
Onchocerca volvulus Deterin homolog 0.0214 0.0914 0.4335
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0142 0.0564 0.0544
Echinococcus granulosus snurportin 1 0.0611 0.283 0.2814
Echinococcus multilocularis rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0142 0.0564 0.0544
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0034 0.0045 0.0024
Trypanosoma cruzi cysteine proteinase, putative 0.0194 0.0817 0.1137
Echinococcus granulosus cathepsin L cysteine protease 0.0194 0.0817 0.0797
Echinococcus granulosus rhodopsin orphan GPCR 0.0065 0.0194 0.0173
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0455 0.208 0.7927
Schistosoma mansoni prolyl oligopeptidase (S09 family) 0.0284 0.1251 0.1232
Mycobacterium ulcerans hypothetical protein 0.0036 0.0053 0.0042
Onchocerca volvulus 0.0065 0.0194 0.084
Schistosoma mansoni terminal deoxycytidyl transferase 0.0117 0.0442 0.0422
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0455 0.208 0.9982
Onchocerca volvulus 0.0065 0.0194 0.084
Loa Loa (eye worm) hypothetical protein 0.0036 0.0053 0.0074
Plasmodium falciparum thioredoxin reductase 0.0047 0.0104 0.05
Loa Loa (eye worm) MH2 domain-containing protein 0.0066 0.0198 0.0276
Trypanosoma cruzi cruzipain precursor, putative 0.0646 0.3002 0.4178
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.1512 0.7186 1
Echinococcus granulosus cysteine protease 0.0194 0.0817 0.0797
Echinococcus granulosus neuropeptide Y receptor 0.0065 0.0194 0.0173
Trypanosoma brucei DNA polymerase IV, putative 0.0117 0.0442 0.1473
Plasmodium vivax vivapain-2 0.0455 0.208 0.9982
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0065 0.0194 0.0173
Onchocerca volvulus 0.0455 0.208 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0142 0.0564 0.2022
Schistosoma mansoni hypothetical protein 0.0065 0.0194 0.0173
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0142 0.0564 0.0785
Echinococcus multilocularis dna polymerase kappa 0.0117 0.0442 0.0422
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0065 0.0194 0.0173
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0239 0.1031 0.1012
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0042 0.0082 0.0273
Loa Loa (eye worm) hypothetical protein 0.0043 0.0085 0.0118
Echinococcus granulosus neuropeptide FF receptor 2 0.0065 0.0194 0.0173
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0065 0.0194 0.0173
Schistosoma mansoni histamine h1 receptor 0.0065 0.0194 0.0173
Trypanosoma cruzi Peptide deformylase 2, putative 0.0174 0.072 0.1002
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0065 0.0194 0.0173
Entamoeba histolytica hypothetical protein 0.0142 0.0564 0.255
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0142 0.0564 0.0544
Echinococcus multilocularis geminin 0.2094 1 1
Loa Loa (eye worm) nuclear factor I 0.0037 0.0055 0.0077
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0194 0.0817 0.2722
Onchocerca volvulus 0.0065 0.0194 0.084
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0036 0.005 0.0029
Schistosoma mansoni hypothetical protein 0.2094 1 1
Loa Loa (eye worm) hypothetical protein 0.0403 0.1827 0.2542
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0065 0.0194 0.0173
Onchocerca volvulus 0.0142 0.0564 0.2635
Brugia malayi Papain family cysteine protease containing protein 0.0142 0.0564 0.0785
Loa Loa (eye worm) histone deacetylase 7A 0.0043 0.0085 0.0118
Trichomonas vaginalis ran, putative 0.0042 0.0082 0.0144
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0146 0.0584 0.1944
Entamoeba histolytica cysteine proteinase, putative 0.0403 0.1827 0.8756
Echinococcus granulosus neuropeptide s receptor 0.0065 0.0194 0.0173
Loa Loa (eye worm) MH1 domain-containing protein 0.0066 0.0198 0.0276
Trypanosoma brucei prolyl oligopeptidase, putative 0.013 0.0506 0.1685
Echinococcus granulosus g protein coupled receptor 0.0065 0.0194 0.0173
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Leishmania major cathepsin L-like protease 0.0455 0.208 0.6928
Loa Loa (eye worm) hypothetical protein 0.0065 0.0194 0.0271
Brugia malayi cathepsin F-like cysteine proteinase 0.0052 0.0132 0.0183
Echinococcus granulosus neuropeptides capa receptor 0.0065 0.0194 0.0173
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0646 0.3002 1
Echinococcus granulosus allatostatin A receptor 0.0065 0.0194 0.0173
Echinococcus granulosus neuropeptides capa receptor 0.0065 0.0194 0.0173
Loa Loa (eye worm) hypothetical protein 0.0403 0.1827 0.2542
Echinococcus multilocularis sex peptide receptor 0.0065 0.0194 0.0173
Plasmodium vivax DNA repair protein REV1, putative 0.0036 0.0053 0.0257
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0194 0.0817 0.3008
Schistosoma mansoni cathepsin s 0.0052 0.0132 0.011
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0036 0.005 0.0029
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.0055 0.0144 0.0385
Schistosoma mansoni Smad4 0.0066 0.0198 0.0177
Brugia malayi cathepsin L precursor 0.0142 0.0564 0.0785
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0646 0.3002 1
Brugia malayi Thioredoxin reductase 0.0047 0.0104 0.0145
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0036 0.0053 0.0205

Activities

Activity type Activity value Assay description Source Reference
Damaged area (functional) = 0.05 % Percentage of gastric damage was measured in rats. ChEMBL. 10197960
ED50 (functional) = 7.1 mg kg-1 ED50 of the compound was measured by CFE assay method. ChEMBL. 10197960
Inhibition (functional) = 77.4 % Percantage inhibition of the prostaglandin synthesis was measured in rats. ChEMBL. 10197960
Lesion frequency (functional) = 12.5 % Lesion frequency of the compound was measured in rats. ChEMBL. 10197960

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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