Detailed information for compound 1698312

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 506.479 | Formula: C23H22O11S
  • H donors: 4 H acceptors: 8 LogP: 0.36 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: OC(=O)[C@@H]1O[C@@H](Oc2ccc(cc2)C2=C(COC2=O)c2ccc(cc2)S(=O)(=O)C)[C@H]([C@H]([C@@H]1O)O)O
  • InChi: 1S/C23H22O11S/c1-35(30,31)14-8-4-11(5-9-14)15-10-32-22(29)16(15)12-2-6-13(7-3-12)33-23-19(26)17(24)18(25)20(34-23)21(27)28/h2-9,17-20,23-26H,10H2,1H3,(H,27,28)/t17-,18-,19-,20+,23+/m0/s1
  • InChiKey: PVWMFNOEZMRTFY-BCYLSMINSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0007 0.0005 0.0018
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0031 0.0031
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0016 0.0031 0.0031
Brugia malayi Zinc knuckle family protein 0.0011 0.0018 0.0018
Schistosoma mansoni glycogen phosphorylase 0.0077 0.023 0.023
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0031 0.0031
Onchocerca volvulus 0.0016 0.0031 0.0159
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0031 0.0031
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0044 0.0188
Echinococcus granulosus NADH ubiquinone oxidoreductase 42 kDa subunit 0.0173 0.0542 0.0542
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0013 0.0025 0.0105
Echinococcus granulosus ribonuclease H1 0.0102 0.031 0.031
Trypanosoma cruzi ribonuclease H1, putative 0.0102 0.031 0.1342
Trypanosoma brucei DNA polymerase epsilon catalytic subunit, putative 0.0007 0.0005 0.0018
Echinococcus multilocularis dro:myosuppressin receptor 0.0016 0.0031 0.0031
Trichomonas vaginalis rotamase, putative 0.0014 0.0026 0.0126
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0031 0.0031
Echinococcus granulosus glycogen phosphorylase 0.0178 0.0557 0.0557
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0173 0.0542 0.6872
Schistosoma mansoni DNA polymerase eta 0.0019 0.0044 0.0043
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0718 0.2305 0.2305
Echinococcus granulosus neuropeptide FF receptor 2 0.0016 0.0031 0.0031
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0018 0.0018
Onchocerca volvulus 0.0016 0.0031 0.0159
Trypanosoma brucei ingi protein (ORF1) 0.0113 0.0347 0.1502
Toxoplasma gondii DNA polymerase (pol2) superfamily protein 0.0022 0.0051 0.0439
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Loa Loa (eye worm) glycogen phosphorylase 0.0178 0.0557 0.0557
Loa Loa (eye worm) carboxylesterase 0.0523 0.1674 0.1674
Onchocerca volvulus 0.0016 0.0031 0.0159
Trypanosoma brucei DNA polymerase alpha catalytic subunit 0.0012 0.0019 0.0078
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0016 0.0031 0.0031
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0095 0.0289 0.0288
Onchocerca volvulus 0.0016 0.0031 0.0159
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0291 0.0291
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0179 0.0589
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0024 0.0103
Entamoeba histolytica hypothetical protein 0.0173 0.0542 0.6872
Loa Loa (eye worm) beta-1,4-galactosyltransferase VII 0.0008 0.0008 0.0008
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0019 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0291 0.0291
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0359 0.1143 1
Schistosoma mansoni protein kinase 0.0011 0.0018 0.0017
Echinococcus granulosus Metazoa galactosyltransferase 0.0031 0.0083 0.0082
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0007 0.0005 0.0005
Brugia malayi Dopamine receptor 0.0016 0.0031 0.0031
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0289 0.125
Toxoplasma gondii histone lysine methyltransferase SET1 0.0036 0.0099 0.0858
Loa Loa (eye worm) hypothetical protein 0.0523 0.1674 0.1674
Onchocerca volvulus 0.0523 0.1674 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0016 0.0031 0.0031
Trypanosoma brucei hypothetical protein, conserved 0.0113 0.0347 0.1502
Loa Loa (eye worm) dihydrofolate reductase 0.0324 0.103 0.1029
Trypanosoma cruzi polo-like protein kinase, putative 0.0095 0.0289 0.125
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0016 0.0031 0.0031
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0095 0.0289 0.125
Leishmania major thymidine kinase, putative 0.0249 0.0786 0.3409
Brugia malayi putative neuropeptide receptor 0.0016 0.0031 0.0031
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0007 0.0005 0.0005
Schistosoma mansoni BC026374 protein (S09 family) 0.0523 0.1674 0.1673
Brugia malayi DNA polymerase alpha catalytic subunit 0.0022 0.0051 0.0051
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0016 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Trichomonas vaginalis NeSL-1_NeSL reverse transcriptases, putative 0.0011 0.0018 0.0079
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Echinococcus multilocularis serotonin receptor 0.0016 0.0031 0.0031
Loa Loa (eye worm) deoxynucleoside kinase 0.0173 0.0542 0.0542
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0007 0.0005 0.0005
Trichomonas vaginalis reverse transcriptases, putative 0.0011 0.0018 0.0079
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0018 0.0018
Brugia malayi hypothetical protein 0.0011 0.0018 0.0018
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0188
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0007 0.0005 0.0018
Echinococcus multilocularis transfer RNA-Ile 0.1306 0.4207 0.4206
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.0044 0.0043
Giardia lamblia DNA polymerase alpha subunit A 0.0022 0.0054 0.0183
Onchocerca volvulus 0.0523 0.1674 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0016 0.0031 0.0031
Loa Loa (eye worm) galactosyltransferase 0.0031 0.0083 0.0082
Echinococcus multilocularis neuroligin 0.0523 0.1674 0.1674
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0359 0.1143 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0523 0.1674 0.1674
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0042 0.0144
Trichomonas vaginalis carboxylesterase domain containing protein, putative 0.0523 0.1674 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Entamoeba histolytica hypothetical protein 0.0173 0.0542 0.6872
Schistosoma mansoni neuropeptide receptor 0.0016 0.0031 0.0031
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0044 0.0188
Brugia malayi hypothetical protein 0.0016 0.0031 0.0031
Onchocerca volvulus 0.0016 0.0031 0.0159
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0011 0.0018 0.0018
Echinococcus granulosus alpha 1A adrenergic receptor 0.0016 0.0031 0.0031
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0031 0.0031
Schistosoma mansoni ap endonuclease 0.0019 0.0042 0.0042
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0016 0.0031 0.0031
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0031 0.0031
Echinococcus granulosus RNA directed DNA polymerase 0.0011 0.0018 0.0018
Brugia malayi GnHR receptor homolog 0.0016 0.0031 0.0031
Trichomonas vaginalis spcc417.12 protein, putative 0.0523 0.1674 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Schistosoma mansoni opsin-like receptor 0.0016 0.0031 0.0031
Brugia malayi follicle stimulating hormone receptor 0.0016 0.0031 0.0031
Schistosoma mansoni neuropeptide receptor 0.0016 0.0031 0.0031
Echinococcus multilocularis RNA directed DNA polymerase 0.0011 0.0018 0.0018
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0291 0.0291
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0018 0.0018
Brugia malayi thymidylate synthase 0.0187 0.0586 0.0586
Trichomonas vaginalis ribonuclease H1, putative 0.0102 0.031 0.1828
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.0044 0.0043
Onchocerca volvulus Serine\/threonine kinase homolog 0.0095 0.0289 0.1701
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0096 0.0291 0.0291
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0523 0.1674 0.1673
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0031 0.0031
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0179 0.0773
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0016 0.0031 0.0031
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0018 0.0018
Onchocerca volvulus Ribonuclease H1 homolog 0.0102 0.031 0.1828
Entamoeba histolytica glycogenphosphorylase, putative 0.0077 0.023 0.2885
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0031 0.0031
Echinococcus granulosus sex peptide receptor 0.0016 0.0031 0.0031
Echinococcus granulosus hypothetical protein 0.0016 0.0031 0.0031
Giardia lamblia DINP protein human, muc B family 0.0019 0.0044 0.0149
Schistosoma mansoni amine GPCR 0.0016 0.0031 0.0031
Schistosoma mansoni opsin-like receptor 0.0016 0.0031 0.0031
Onchocerca volvulus 0.0523 0.1674 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0031 0.0031
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0007 0.0005 0.0005
Brugia malayi reverse transcriptase 0.0011 0.0018 0.0018
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0016 0.0031 0.0031
Brugia malayi DNA polymerase family B containing protein 0.0007 0.0005 0.0005
Trypanosoma cruzi DNA polymerase I alpha catalytic subunit, putative 0.0012 0.0019 0.0078
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0018 0.0018
Echinococcus granulosus expressed protein 0.0014 0.0026 0.0026
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.0044 0.0234
Echinococcus granulosus Ribosomal protein L34a 0.0023 0.0056 0.0056
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0016 0.0031 0.0031
Schistosoma mansoni neuropeptide receptor 0.0016 0.0031 0.0031
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0179 0.156
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0018 0.0018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0031 0.0031
Trypanosoma brucei SLACS reverse transcriptase, putative 0.0011 0.0018 0.0076
Schistosoma mansoni NADH-ubiquinone oxidoreductase 0.0173 0.0542 0.0541
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0042 0.0181
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0016 0.0031 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0188
Brugia malayi DNA polymerase delta catalytic subunit 0.0007 0.0005 0.0005
Brugia malayi AKH receptor 0.0016 0.0031 0.0031
Echinococcus multilocularis glycogen phosphorylase 0.0178 0.0557 0.0557
Brugia malayi hypothetical protein 0.0016 0.0031 0.0031
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0031 0.0031
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0042 0.0365
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Schistosoma mansoni growth hormone secretagogue receptor 0.0016 0.0031 0.0031
Echinococcus granulosus neuropeptide receptor A26 0.0016 0.0031 0.0031
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0031 0.0031
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0027 0.0067 0.0067
Schistosoma mansoni serine/threonine protein kinase 0.0012 0.0019 0.0018
Trypanosoma brucei ingi protein (ORF1) 0.0113 0.0347 0.1502
Loa Loa (eye worm) melatonin receptor type 1A 0.0016 0.0031 0.0031
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0031 0.0031
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0042 0.0042
Echinococcus multilocularis para nitrobenzyl esterase 0.0523 0.1674 0.1674
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0179 0.0178
Echinococcus multilocularis allatostatin A receptor 0.0016 0.0031 0.0031
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0291 0.0291
Brugia malayi hypothetical protein 0.0016 0.0031 0.0031
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0031 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0188
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.3096 1 1
Brugia malayi Dopamine receptor protein 1 0.0016 0.0031 0.0031
Trichomonas vaginalis reverse transcriptase [C. elegans], putative 0.0011 0.0018 0.0079
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0011 0.0018 0.0018
Echinococcus granulosus dihydrofolate reductase 0.0324 0.103 0.1029
Plasmodium vivax DNA polymerase zeta catalytic subunit, putative 0.0007 0.0005 0.0037
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0042 0.0181
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0031 0.0031
Entamoeba histolytica serine/threonine protein kinase, putative 0.0095 0.0289 0.3632
Schistosoma mansoni myosin xvIII 0.0016 0.0031 0.0031
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0042 0.0225
Schistosoma mansoni beta-14-galactosyltransferase 0.0031 0.0083 0.0082
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0031 0.0031
Brugia malayi reverse transcriptase 0.0011 0.0018 0.0018
Loa Loa (eye worm) MH2 domain-containing protein 0.0048 0.0137 0.0137
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0133 0.077
Brugia malayi Serotonin receptor 0.0016 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0523 0.1674 0.1674
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0096 0.0291 0.0291
Leishmania major DNA polymerase I alpha catalytic subunit, putative 0.0012 0.0019 0.0078
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0042 0.0225
Schistosoma mansoni hypothetical protein 0.0016 0.0031 0.0031
Echinococcus multilocularis acetylcholinesterase 0.3096 1 1
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.001 0.0013 0.0013
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0359 0.1143 0.4957
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0523 0.1674 0.5501
Schistosoma mansoni beta-14-galactosyltransferase 0.0008 0.0008 0.0007
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0013 0.0025 0.0105
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0018 0.0018
Echinococcus granulosus orexin receptor type 2 0.0016 0.0031 0.0031
Echinococcus granulosus neuropeptide receptor 0.0016 0.0031 0.0031
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0031 0.0031
Entamoeba histolytica glycogen phosphorylase, putative 0.0178 0.0557 0.707
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0007 0.0005 0.0005
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0013 0.0025 0.0105
Echinococcus multilocularis BC026374 protein (S09 family) 0.0523 0.1674 0.1674
Loa Loa (eye worm) hypothetical protein 0.0523 0.1674 0.1674
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0031 0.0031
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0018 0.0018
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0096 0.0291 0.0291
Trypanosoma cruzi hypothetical protein, conserved 0.0011 0.0018 0.0076
Mycobacterium tuberculosis Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) 0.0942 0.3028 1
Echinococcus granulosus KRAB A domain containing protein 0.0011 0.0018 0.0018
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.0044 0.0234
Brugia malayi Tachykinin-like peptides receptor 99D 0.0016 0.0031 0.0031
Trichomonas vaginalis thymidine kinase, putative 0.0249 0.0786 0.4682
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0031 0.0031
Trypanosoma brucei unspecified product 0.0019 0.0044 0.0188
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0031 0.0031
Schistosoma mansoni beta-14-galactosyltransferase 0.0008 0.0008 0.0007
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0031 0.0031
Trypanosoma brucei unspecified product 0.0013 0.0024 0.0103
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0016 0.0031 0.0031
Echinococcus granulosus neuropeptide receptor 0.0016 0.0031 0.0031
Echinococcus multilocularis Glycosyl transferase, family 35 0.0178 0.0557 0.0557
Giardia lamblia Thymidine kinase 0.0249 0.0786 0.2703
Trypanosoma brucei unspecified product 0.0013 0.0024 0.0103
Schistosoma mansoni histamine h1 receptor 0.0016 0.0031 0.0031
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.0044 0.0044
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0031 0.0031
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0031 0.0031
Mycobacterium ulcerans glycogen phosphorylase GlgP 0.0077 0.023 0.0758
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0018 0.0018
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0016 0.0031 0.0031
Giardia lamblia Kinase, PLK 0.0095 0.0289 0.0991
Echinococcus granulosus acetylcholinesterase 0.3096 1 1
Echinococcus granulosus thymidine phosphorylase 0.0942 0.3028 0.3028
Schistosoma mansoni hypothetical protein 0.0505 0.1614 0.1613
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0011 0.0018 0.006
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0718 0.2305 0.2305
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0188
Mycobacterium tuberculosis Hypothetical protein 0.0089 0.0269 0.0833
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0031 0.0031
Brugia malayi polk-prov protein 0.0006 0.0001 0.0001
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0018 0.0018
Entamoeba histolytica glycogen phosphorylase, putative 0.0077 0.023 0.2885
Schistosoma mansoni thymidine kinase 0.1306 0.4207 0.4206
Schistosoma mansoni neuropeptide f receptor 76f 0.0016 0.0031 0.0031
Schistosoma mansoni adenoreceptor 0.0016 0.0031 0.0031
Brugia malayi Serotonin receptor 0.0016 0.0031 0.0031
Schistosoma mansoni hypothetical protein 0.0011 0.0018 0.0017
Loa Loa (eye worm) hypothetical protein 0.0523 0.1674 0.1674
Entamoeba histolytica glycogen phosphorylase, putative 0.0077 0.023 0.2885
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0031 0.0031
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0042 0.0042
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0173 0.0542 0.6872
Brugia malayi Galactosyltransferase family protein 0.0031 0.0083 0.0083
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0018 0.0018
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0031 0.0031
Onchocerca volvulus 0.0016 0.0031 0.0159
Toxoplasma gondii DNA polymerase 0.0007 0.0005 0.0037
Brugia malayi G-protein coupled receptor 0.0016 0.0031 0.0031
Entamoeba histolytica hypothetical protein 0.0173 0.0542 0.6872
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0031 0.0031
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0042 0.0181
Echinococcus granulosus 7TM GPCR rhodopsin 0.0016 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0018 0.0018
Echinococcus granulosus acetylcholinesterase 0.3096 1 1
Echinococcus granulosus cpg binding protein 0.002 0.0047 0.0046
Loa Loa (eye worm) UDP-Galactose:b-N-acetylglucosamine b1,4-galactosyltransferase 4 0.0008 0.0008 0.0008
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0187 0.0586 0.0585
Giardia lamblia Ribonuclease H 0.0102 0.031 0.1064
Echinococcus granulosus g protein coupled receptor 0.0016 0.0031 0.0031
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0016 0.0031 0.0031
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0289 0.1701
Schistosoma mansoni rotamase 0.0014 0.0026 0.0025
Entamoeba histolytica hypothetical protein 0.0173 0.0542 0.6872
Echinococcus granulosus thymidine kinase 0.1306 0.4207 0.4206
Echinococcus granulosus somatostatin receptor 0.0016 0.0031 0.0031
Brugia malayi neuropeptide F receptor 0.0016 0.0031 0.0031
Echinococcus multilocularis dna polymerase kappa 0.0019 0.0044 0.0044
Brugia malayi RNase H family protein 0.0102 0.031 0.031
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0018 0.0018
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0031 0.0031
Loa Loa (eye worm) galactosyltransferase 0.0008 0.0008 0.0008
Trypanosoma cruzi DNA polymerase eta, putative 0.0019 0.0044 0.0188
Brugia malayi G protein-coupled receptor 0.0016 0.0031 0.0031
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0359 0.1143 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0031 0.0031
Echinococcus granulosus g protein coupled receptor 0.0016 0.0031 0.0031
Echinococcus granulosus beta 14 N acetylgalactosaminyltransferase 0.0008 0.0008 0.0008
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0016 0.0031 0.0031
Echinococcus multilocularis serotonin receptor 0.0016 0.0031 0.0031
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0016 0.0031 0.0031
Echinococcus granulosus Thymidine kinase 2 mitochondrial 0.1306 0.4207 0.4206
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0016 0.0031 0.0031
Mycobacterium ulcerans thymidine phosphorylase 0.0942 0.3028 1
Chlamydia trachomatis dihydrofolate reductase 0.0324 0.103 1
Loa Loa (eye worm) hypothetical protein 0.3096 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0031 0.0031
Schistosoma mansoni acetylcholinesterase 0.0523 0.1674 0.1673
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0031 0.0031
Brugia malayi Deoxynucleoside kinase family protein 0.0173 0.0542 0.0542
Echinococcus granulosus dro:myosuppressin receptor 0.0016 0.0031 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0188
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0018 0.0018
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0007 0.0005 0.0004
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0523 0.1674 0.1673
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0031 0.0031
Schistosoma mansoni amine GPCR 0.0016 0.0031 0.0031
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0007 0.0005 0.0018
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0031 0.0031
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0016 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Schistosoma mansoni phenylalanine decarboxylase 0.0008 0.0008 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0016 0.0031 0.0031
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0031 0.0031
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0031 0.0031
Onchocerca volvulus 0.0187 0.0586 0.348
Echinococcus multilocularis beta 1,4 galactosyltransferase 7 0.0008 0.0008 0.0008
Brugia malayi RNase H family protein 0.0102 0.031 0.031
Onchocerca volvulus 0.0016 0.0031 0.0159
Echinococcus multilocularis thymidine phosphorylase 0.0942 0.3028 0.3028
Trichomonas vaginalis conserved hypothetical protein 0.0014 0.0026 0.0126
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0024 0.0103
Plasmodium falciparum DNA polymerase alpha catalytic subunit A 0.0008 0.0005 0.0042
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0016 0.0031 0.0031
Brugia malayi larval opioid receptor 0.0016 0.0031 0.0031
Brugia malayi hypothetical protein 0.0011 0.0018 0.0018
Echinococcus granulosus carboxylesterase 5A 0.3096 1 1
Echinococcus granulosus g-protein coupled receptor 0.0016 0.0031 0.0031
Leishmania major C-8 sterol isomerase-like protein 0.0718 0.2305 1
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0007 0.0005 0.0004
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0007 0.0005 0.0037
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.0044 0.0086
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0031 0.0031
Treponema pallidum ribonuclease H (rnhA) 0.0102 0.031 1
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0324 0.103 0.3361
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0011 0.0018 0.006
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0031 0.0031
Schistosoma mansoni beta-14-galactosyltransferase 0.0008 0.0008 0.0007
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0031 0.0031
Echinococcus granulosus family S9 non peptidase ue S09 family 0.0523 0.1674 0.1674
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Schistosoma mansoni neuropeptide receptor 0.0016 0.0031 0.0031
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0523 0.1674 0.1673
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0007 0.0005 0.0005
Echinococcus multilocularis G-protein coupled receptor, putative 0.0016 0.0031 0.0031
Brugia malayi hypothetical protein 0.0011 0.0018 0.0018
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0007 0.0005 0.0004
Brugia malayi hypothetical protein 0.0016 0.0031 0.0031
Echinococcus granulosus 7tm_1 domain containing protein 0.0016 0.0031 0.0031
Echinococcus multilocularis orexin receptor type 2 0.0016 0.0031 0.0031
Onchocerca volvulus 0.0016 0.0031 0.0159
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0324 0.103 0.3399
Schistosoma mansoni biogenic amine receptor 0.0016 0.0031 0.0031
Plasmodium vivax DNA polymerase alpha, putative 0.0022 0.0051 0.0439
Schistosoma mansoni gliotactin 0.0523 0.1674 0.1673
Toxoplasma gondii peptidylprolyl isomerase 0.0013 0.0025 0.0211
Mycobacterium tuberculosis Carboxylesterase LipT 0.0523 0.1674 0.5501
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0042 0.0042
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0289 0.1701
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0289 0.1701
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.0024 0.0103
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0011 0.0018 0.006
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0014 0.0026 0.0026
Brugia malayi Carboxylesterase family protein 0.3096 1 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0089 0.0269 0.1163
Trypanosoma brucei unspecified product 0.0113 0.0347 0.1502
Entamoeba histolytica glycogen phosphorylase, putative 0.0178 0.0557 0.707
Brugia malayi hypothetical protein 0.0016 0.0031 0.0031
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0289 0.1701
Echinococcus granulosus tachykinin peptides receptor 99D 0.0016 0.0031 0.0031
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0031 0.0031
Schistosoma mansoni amine GPCR 0.0016 0.0031 0.0031
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0031 0.0031
Onchocerca volvulus 0.0016 0.0031 0.0159
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Schistosoma mansoni hypothetical protein 0.0016 0.0031 0.0031
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.0044 0.0086
Echinococcus granulosus serotonin receptor 0.0016 0.0031 0.0031
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0173 0.0542 0.6872
Mycobacterium ulcerans carboxylesterase, LipT 0.0523 0.1674 0.5527
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Trypanosoma brucei polo-like protein kinase 0.0095 0.0289 0.125
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Giardia lamblia DNA polymerase epsilon, catalytic subunit 0.0007 0.0005 0.0015
Echinococcus multilocularis thymidine kinase 0.1306 0.4207 0.4206
Echinococcus granulosus BC026374 protein S09 family 0.0523 0.1674 0.1674
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Onchocerca volvulus 0.0523 0.1674 1
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0179 0.0178
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0016 0.0031 0.0031
Onchocerca volvulus 0.0011 0.0018 0.0079
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0018 0.0018
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0011 0.0018 0.0018
Echinococcus multilocularis thymidylate synthase 0.0187 0.0586 0.0585
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0031 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0188
Trypanosoma brucei DNA polymerase eta, putative 0.0019 0.0044 0.0188
Giardia lamblia Reverse transcriptase/endonuclease, putative 0.0011 0.0018 0.006
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0018 0.0018
Entamoeba histolytica hypothetical protein 0.0173 0.0542 0.6872
Brugia malayi G-protein coupled receptor 0.0016 0.0031 0.0031
Schistosoma mansoni amine GPCR 0.0016 0.0031 0.0031
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0188
Trypanosoma brucei retrotransposon hot spot protein 4 (RHS4), interrupted 0.0113 0.0347 0.1502
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0523 0.1674 0.1674
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.0044 0.0044
Echinococcus multilocularis dna polymerase eta 0.0019 0.0044 0.0044
Trypanosoma cruzi DNA polymerase epsilon catalytic subunit, putative 0.0007 0.0005 0.0018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Trichomonas vaginalis DNA polymerase alpha catalytic subunit, putative 0.0012 0.0019 0.0082
Schistosoma mansoni glycogen phosphorylase 0.0178 0.0557 0.0557
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.0542 0.3217
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0018 0.0018
Toxoplasma gondii exonuclease III APE 0.0019 0.0042 0.0365
Echinococcus granulosus dna polymerase kappa 0.0019 0.0044 0.0044
Schistosoma mansoni biogenic amine receptor 0.0016 0.0031 0.0031
Onchocerca volvulus 0.0011 0.0018 0.0079
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.0542 0.3217
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.0542 0.3217
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0031 0.0031
Loa Loa (eye worm) TYRA-2 protein 0.0016 0.0031 0.0031
Echinococcus multilocularis Ribosomal protein L34a 0.0023 0.0056 0.0056
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0044 0.0188
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0027 0.0067 0.0067
Trichomonas vaginalis thymidine kinase, putative 0.0249 0.0786 0.4682
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0018 0.0018
Mycobacterium ulcerans anthranilate phosphoribosyltransferase 0.0266 0.0841 0.2776
Trichomonas vaginalis thymidine kinase, putative 0.0249 0.0786 0.4682
Mycobacterium leprae Probable anthranilate phosphoribosyltransferase TrpD 0.0266 0.0841 0.5754
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Giardia lamblia Hypothetical protein 0.0173 0.0542 0.1862
Trypanosoma brucei DNA polymerase zeta catalytic subunit, putative 0.0007 0.0005 0.0018
Trypanosoma cruzi ribonuclease H1, putative 0.0102 0.031 0.1342
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0095 0.0289 0.0288
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0031 0.0031
Echinococcus multilocularis dihydrofolate reductase 0.0324 0.103 0.1029
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0188
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0179 0.0179
Echinococcus granulosus G protein coupled receptor 139 0.0016 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Entamoeba histolytica DNA polymerase alpha catalytic subunit, putative 0.0008 0.0005 0.0008
Echinococcus multilocularis expressed protein 0.0014 0.0026 0.0026
Leishmania major DNA polymerase kappa, putative 0.0019 0.0044 0.0188
Onchocerca volvulus 0.0019 0.0043 0.0229
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0016 0.0031 0.0031
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0031 0.0031
Echinococcus multilocularis acetylcholinesterase 0.3096 1 1
Schistosoma mansoni phosphoglucomutase 0.0102 0.031 0.0309
Schistosoma mansoni kinase 0.0048 0.0137 0.0137
Brugia malayi Carboxylesterase family protein 0.0523 0.1674 0.1674
Echinococcus granulosus thymidylate synthase 0.0187 0.0586 0.0585
Toxoplasma gondii hypothetical protein 0.0008 0.0008 0.0063
Onchocerca volvulus 0.0016 0.0031 0.0159
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0007 0.0005 0.0037
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.3096 1 1
Schistosoma mansoni beta-14-galactosyltransferase 0.0008 0.0008 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0031 0.0031
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0179 0.0179
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.0542 0.3217
Brugia malayi hypothetical protein 0.0016 0.0031 0.0031
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0016 0.0031 0.0031
Onchocerca volvulus 0.0016 0.0031 0.0159
Echinococcus multilocularis NADH ubiquinone oxidoreductase 42 kDa subunit 0.0173 0.0542 0.0542
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Schistosoma mansoni alpha-1 adrenergic receptor 0.0016 0.0031 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0173 0.0542 0.3217
Echinococcus granulosus g protein coupled receptor 0.0016 0.0031 0.0031
Brugia malayi Carboxylesterase family protein 0.0523 0.1674 0.1674
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0031 0.0031
Onchocerca volvulus 0.0016 0.0031 0.0159
Loa Loa (eye worm) carboxylesterase 0.0523 0.1674 0.1674
Trypanosoma brucei SLACS retrotransposable element (part), putative 0.0011 0.0018 0.0076
Trichomonas vaginalis rotamase, putative 0.0013 0.0025 0.0119
Schistosoma mansoni hypothetical protein 0.0011 0.0018 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0289 0.1701
Brugia malayi Zinc knuckle family protein 0.0011 0.0018 0.0018
Entamoeba histolytica deoxyuridine 5-triphosphate nucleotidohydrolase domain containing protein 0.0173 0.0542 0.6872
Echinococcus multilocularis ribonuclease H1 0.0102 0.031 0.031
Echinococcus multilocularis G protein coupled receptor 139 0.0016 0.0031 0.0031
Schistosoma mansoni cpg binding protein 0.0019 0.0043 0.0043
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0188
Echinococcus granulosus neuropeptide s receptor 0.0016 0.0031 0.0031
Leishmania major DNA polymerase eta, putative 0.0019 0.0044 0.0188
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.0044 0.0044
Brugia malayi Carboxylesterase family protein 0.0523 0.1674 0.1674
Trypanosoma cruzi thymidine kinase, putative 0.0249 0.0786 0.3409
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0031 0.0031
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0016 0.0031 0.0031
Echinococcus granulosus beta 14 galactosyltransferase 7 0.0008 0.0008 0.0008
Brugia malayi RNase H family protein 0.0102 0.031 0.031
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0042 0.0138
Echinococcus multilocularis Metazoa galactosyltransferase 0.0027 0.0067 0.0067
Leishmania major ribonuclease H1, putative 0.0102 0.031 0.1342
Brugia malayi carbohydrate phosphorylase 0.0178 0.0557 0.0557
Entamoeba histolytica hypothetical protein 0.0173 0.0542 0.6872
Toxoplasma gondii ribonuclease HI protein 0.0102 0.031 0.2707
Giardia lamblia Glycogen phosphorylase 0.0178 0.0557 0.1916
Echinococcus multilocularis carboxylesterase 5A 0.3096 1 1
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0042 0.0081
Brugia malayi neuropeptide F receptor 0.0016 0.0031 0.0031
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0289 0.1701
Echinococcus multilocularis neuropeptide FF receptor 2 0.0016 0.0031 0.0031
Schistosoma mansoni beta-14-galactosyltransferase 0.0008 0.0008 0.0007
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0031 0.0031
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0016 0.0031 0.0031
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0044 0.0044
Echinococcus multilocularis neuropeptide receptor A26 0.0016 0.0031 0.0031
Brugia malayi hypothetical protein 0.0016 0.0031 0.0031
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0031 0.0031
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0344 0.1093 0.1093
Trypanosoma brucei thymidine kinase 0.0249 0.0786 0.3409
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0007 0.0005 0.0005
Trichomonas vaginalis reverse transcriptases, putative 0.0011 0.0018 0.0079
Schistosoma mansoni cpg binding protein 0.002 0.0047 0.0046
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0011 0.0018 0.0018
Echinococcus granulosus para nitrobenzyl esterase 0.0523 0.1674 0.1674
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0044 0.0143
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0031 0.0031
Brugia malayi Dihydrofolate reductase 0.0324 0.103 0.103
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0044 0.0188
Trypanosoma brucei RNA helicase, putative 0.0505 0.1614 0.6999
Giardia lamblia Deoxynucleoside kinase 0.0904 0.2907 1
Toxoplasma gondii DNA polymerase family B protein 0.0007 0.0005 0.0037
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0031 0.0031
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0018 0.0018
Brugia malayi ORL1-like opioid receptor 0.0016 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Echinococcus multilocularis neuropeptide s receptor 0.0016 0.0031 0.0031
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0041 0.0113 0.0112
Echinococcus multilocularis family S9 non peptidase ue (S09 family) 0.0523 0.1674 0.1674
Trichomonas vaginalis DNA polymerase II, putative 0.0012 0.0019 0.0082
Schistosoma mansoni phosphoglucomutase 0.0102 0.031 0.0309
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0013 0.0025 0.0105
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0095 0.0289 0.0288
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0007 0.0005 0.0005
Trypanosoma brucei ribonuclease H1 0.0102 0.031 0.1342
Trichomonas vaginalis CAMK family protein kinase 0.0047 0.0133 0.077
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0031 0.0031
Onchocerca volvulus 0.0523 0.1674 1
Brugia malayi MH2 domain containing protein 0.0048 0.0137 0.0137
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0096 0.0291 0.0291
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0031 0.0031
Echinococcus granulosus allatostatin A receptor 0.0016 0.0031 0.0031
Echinococcus multilocularis Metazoa galactosyltransferase 0.0031 0.0083 0.0082
Onchocerca volvulus Telomerase reverse transcriptase homolog 0.0011 0.0018 0.0079
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0016 0.0031 0.0031
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0324 0.103 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.0044 0.0188
Entamoeba histolytica hypothetical protein 0.0173 0.0542 0.6872
Echinococcus multilocularis thymidine kinase 0.1306 0.4207 0.4206
Schistosoma mansoni biogenic amine receptor 0.0016 0.0031 0.0031
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0031 0.0031
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0179 0.0589
Loa Loa (eye worm) acetylcholinesterase 1 0.3096 1 1
Onchocerca volvulus 0.0016 0.0031 0.0159
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.0044 0.0188
Echinococcus multilocularis somatostatin receptor 0.0016 0.0031 0.0031
Echinococcus granulosus glycogen phosphorylase 0.0178 0.0557 0.0557
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Echinococcus granulosus Glycosyl transferase family 35 0.0178 0.0557 0.0557
Mycobacterium tuberculosis Conserved hypothetical protein 0.0077 0.023 0.0703
Onchocerca volvulus 0.0016 0.0031 0.0159
Schistosoma mansoni serine/threonine protein kinase 0.0095 0.0289 0.0288
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.0044 0.0143
Leishmania major DNA polymerase epsilon catalytic subunit, putative 0.0007 0.0005 0.0018
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0179 0.0534
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0014 0.0026 0.0026
Giardia lamblia Reverse transcriptase/endonuclease 0.0011 0.0018 0.006
Schistosoma mansoni glycogen phosphorylase 0.0178 0.0557 0.0557
Echinococcus multilocularis glycogen phosphorylase 0.0178 0.0557 0.0557
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Giardia lamblia Deoxyguanosine kinase/deoxyadenosine kinase subunit, putative 0.0173 0.0542 0.1862
Mycobacterium ulcerans thymidylate synthase 0.0187 0.0586 0.1932
Schistosoma mansoni opsin-like receptor 0.0016 0.0031 0.0031
Trichomonas vaginalis CAMK family protein kinase 0.0095 0.0289 0.1701
Echinococcus granulosus RNA directed DNA polymerase reverse transcriptase 0.0011 0.0018 0.0018
Wolbachia endosymbiont of Brugia malayi ribonuclease HI 0.0102 0.031 1
Schistosoma mansoni hypothetical protein 0.0016 0.0031 0.0031
Trichomonas vaginalis glycogen phosphorylase, putative 0.0178 0.0557 0.331
Brugia malayi Pao retrotransposon peptidase family protein 0.0011 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Trypanosoma cruzi thymidine kinase, putative 0.0249 0.0786 0.3409
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0042 0.0365
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.0044 0.0044
Brugia malayi Galactosyltransferase family protein 0.0008 0.0008 0.0008
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0187 0.0586 0.1886
Onchocerca volvulus 0.0016 0.0031 0.0159
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0031 0.0031
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0016 0.0031 0.0031
Onchocerca volvulus 0.0016 0.0031 0.0159
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0018 0.0018
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Echinococcus granulosus thymidine kinase 0.1306 0.4207 0.4206
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0044 0.0188
Entamoeba histolytica hypothetical protein 0.0173 0.0542 0.6872
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0031 0.0031
Brugia malayi Dopamine receptor protein 2 0.0016 0.0031 0.0031
Brugia malayi reverse transcriptase 0.0011 0.0018 0.0018
Mycobacterium tuberculosis Probable glycogen phosphorylase GlgP 0.0077 0.023 0.0705
Brugia malayi hypothetical protein 0.0011 0.0018 0.0018
Brugia malayi hypothetical protein 0.0016 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0523 0.1674 0.1674
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0007 0.0005 0.0015
Echinococcus granulosus peptide allatostatin:somatostatin 0.0016 0.0031 0.0031
Schistosoma mansoni cpg binding protein 0.002 0.0047 0.0046
Brugia malayi dihydrofolate reductase family protein 0.0324 0.103 0.103
Onchocerca volvulus Glycogen phosphorylase homolog 0.0178 0.0557 0.331
Loa Loa (eye worm) CXXC zinc finger family protein 0.0019 0.0043 0.0043
Loa Loa (eye worm) thymidylate synthase 0.0187 0.0586 0.0585
Entamoeba histolytica hypothetical protein 0.0173 0.0542 0.6872
Onchocerca volvulus 0.0016 0.0031 0.0159
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.0044 0.0188
Plasmodium vivax DNA polymerase epsilon, catalytic subunit a, putative 0.0007 0.0005 0.0037
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0359 0.1143 0.4957
Loa Loa (eye worm) carboxylesterase 0.3096 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0016 0.0031 0.0031
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0013 0.0025 0.0255
Schistosoma mansoni dihydrofolate reductase 0.0324 0.103 0.1029
Mycobacterium tuberculosis Probable anthranilate phosphoribosyltransferase TrpD 0.0266 0.0841 0.2734
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0523 0.1674 0.5501
Brugia malayi Carboxylesterase family protein 0.0523 0.1674 0.1674
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0359 0.1143 0.4957
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.0044 0.0188
Schistosoma mansoni beta-14-galactosyltransferase 0.0031 0.0083 0.0082
Brugia malayi putative neuropeptide receptor NPR1 0.0016 0.0031 0.0031
Schistosoma mansoni phosphoglucomutase 0.0102 0.031 0.0309
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Brugia malayi G protein-coupled receptor F59B2.13 0.0016 0.0031 0.0031
Trichomonas vaginalis conserved hypothetical protein 0.0089 0.0269 0.1581
Echinococcus multilocularis cpg binding protein 0.002 0.0047 0.0046
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0179 0.0589
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0016 0.0031 0.0159
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0031 0.0031
Onchocerca volvulus Neuropeptide F receptor homolog 0.0016 0.0031 0.0159
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0042 0.048
Echinococcus multilocularis RNA directed DNA polymerase (reverse transcriptase) 0.0011 0.0018 0.0018
Brugia malayi hypothetical protein 0.0016 0.0031 0.0031
Echinococcus multilocularis g-protein coupled receptor 0.0016 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0031 0.0031
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0027 0.0067 0.0066
Schistosoma mansoni ap endonuclease 0.0019 0.0042 0.0042
Brugia malayi hypothetical protein 0.0089 0.0269 0.0269
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0007 0.0005 0.0018
Echinococcus multilocularis beta 1,4 N acetylgalactosaminyltransferase 0.0008 0.0008 0.0008
Brugia malayi CXXC zinc finger family protein 0.0019 0.0043 0.0043
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0036 0.0099 0.0565
Trypanosoma brucei C-8 sterol isomerase, putative 0.0718 0.2305 1
Schistosoma mansoni hypothetical protein 0.0016 0.0031 0.0031
Schistosoma mansoni scy1(yeast) protein kinase-like 0.0011 0.0018 0.0017
Entamoeba histolytica thymidine kinase, putative 0.0249 0.0786 1
Schistosoma mansoni beta-14-galactosyltransferase 34-related 0.0008 0.0008 0.0007
Brugia malayi sulfakinin receptor protein 0.0016 0.0031 0.0031
Loa Loa (eye worm) transcription factor SMAD2 0.0048 0.0137 0.0137
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0096 0.0291 0.0291
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0042 0.0042
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Echinococcus granulosus fmrfamide receptor 0.0016 0.0031 0.0031
Brugia malayi RE15519p 0.0016 0.0031 0.0031
Brugia malayi Melatonin receptor type 1A 0.0016 0.0031 0.0031
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0031 0.0031
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0031 0.0031
Trichomonas vaginalis glycogen phosphorylase, putative 0.0178 0.0557 0.331
Brugia malayi beta-1,4-galactosyltransferase VII 0.0008 0.0008 0.0008
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0016 0.0031 0.0031
Schistosoma mansoni beta-14-galactosyltransferase 0.0008 0.0008 0.0007
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0042 0.0181
Echinococcus granulosus dna polymerase eta 0.0019 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0718 0.2305 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0031 0.0031
Trypanosoma brucei Endonuclease-reverse transcriptase/Reverse transcriptase (RNA-dependent DNA polymerase), putative 0.0011 0.0018 0.0076
Brugia malayi hypothetical protein 0.0016 0.0031 0.0031
Brugia malayi serine/threonine-protein kinase plk-2 0.0095 0.0289 0.0289
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.0044 0.0501
Loa Loa (eye worm) hypothetical protein 0.0036 0.0099 0.0099
Schistosoma mansoni amine GPCR 0.0016 0.0031 0.0031
Giardia lamblia Hypothetical protein 0.0173 0.0542 0.1862
Echinococcus granulosus neuroligin 0.0523 0.1674 0.1674
Loa Loa (eye worm) hypothetical protein 0.0016 0.0031 0.0031
Brugia malayi hypothetical protein 0.0523 0.1674 0.1674
Schistosoma mansoni neuroligin 3 (S09 family) 0.0523 0.1674 0.1673
Echinococcus multilocularis sex peptide receptor 0.0016 0.0031 0.0031
Loa Loa (eye worm) hypothetical protein 0.0367 0.1169 0.1169

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) > 33 uM The compound was evaluated for its inhibitory activity against COX- 2. ChEMBL. 11128651
IC50 (binding) > 100 uM The compound was evaluated for its inhibitory activity against COX- 1. ChEMBL. 11128651

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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