Detailed information for compound 1703874

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 313.734 | Formula: C14H16ClNO5
  • H donors: 2 H acceptors: 3 LogP: 2.35 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(COC(=O)c1cc(Cl)ccc1O)NCC1CCCO1
  • InChi: 1S/C14H16ClNO5/c15-9-3-4-12(17)11(6-9)14(19)21-8-13(18)16-7-10-2-1-5-20-10/h3-4,6,10,17H,1-2,5,7-8H2,(H,16,18)
  • InChiKey: LMZXMDKNXMUPIK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0065 0.0506 0.0491
Brugia malayi steroid hormone receptor 0.0065 0.0506 0.0557
Echinococcus multilocularis ecdysone induced protein 78C 0.0065 0.0506 0.0491
Mycobacterium ulcerans polyprenyl synthetase IdsB 0.0054 0.0353 0.072
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0065 0.0506 0.0473
Echinococcus granulosus ubiquitin specific protease 41 0.0045 0.023 0.0215
Schistosoma mansoni microtubule-associated protein tau 0.0754 1 1
Loa Loa (eye worm) hypothetical protein 0.0058 0.0418 0.0491
Loa Loa (eye worm) MH2 domain-containing protein 0.0319 0.4003 0.4709
Schistosoma mansoni cellular tumor antigen P53 0.0078 0.0688 0.0655
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0065 0.0506 0.0473
Loa Loa (eye worm) hypothetical protein 0.0041 0.0183 0.0215
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0418 0.0384
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0058 0.0418 0.0384
Schistosoma mansoni hypothetical protein 0.0056 0.0383 0.0349
Loa Loa (eye worm) nuclear receptor NHR-67 0.0031 0.0034 0.0041
Loa Loa (eye worm) hypothetical protein 0.0628 0.8266 0.9723
Brugia malayi hypothetical protein 0.0034 0.0085 0.006
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0176 0.2044 0.2404
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0034 0.0085 0.007
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0065 0.0506 0.0557
Echinococcus multilocularis tar DNA binding protein 0.0128 0.138 0.1367
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0208 0.0174
Echinococcus multilocularis beta LACTamase domain containing family member 0.0041 0.0183 0.0168
Loa Loa (eye worm) latrophilin receptor protein 2 0.0056 0.0383 0.045
Onchocerca volvulus 0.0041 0.0183 0.0249
Echinococcus multilocularis tumor protein p63 0.0533 0.6951 0.6946
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0065 0.0506 0.0557
Mycobacterium tuberculosis Probable polyprenyl-diphosphate synthase GrcC2 (polyprenyl pyrophosphate synthetase) 0.0054 0.0353 0.0554
Brugia malayi cytoplasmic intermediate filament protein 0.0032 0.0059 0.0029
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0043 0.0208 0.0193
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0031 0.0034 0.0019
Schistosoma mansoni survival motor neuron protein 0.0037 0.0124 0.009
Brugia malayi nuclear receptor RXR 0.0034 0.0085 0.006
Echinococcus granulosus tumor protein p63 0.0533 0.6951 0.6946
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0264 0.3249 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0528 0.1462
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0054 0.0353 0.0376
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0532 0.6936 0.8159
Brugia malayi Intermediate filament tail domain containing protein 0.006 0.0446 0.0486
Loa Loa (eye worm) nuclear hormone receptor 0.0031 0.0034 0.0041
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0045 0.023 0.0231
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0183 0.0149
Echinococcus multilocularis thyroid hormone receptor alpha 0.0065 0.0506 0.0491
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0213 0.2542 0.406
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0155 0.0121
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0528 0.1462
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0043 0.0208 0.0193
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.006 0.0446 0.0524
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0054 0.0353 0.072
Loa Loa (eye worm) hypothetical protein 0.0056 0.0384 0.0452
Leishmania major farnesyl pyrophosphate synthase 0.0213 0.2542 1
Mycobacterium tuberculosis Probable multifunctional geranylgeranyl pyrophosphate synthetase IdsA1 (GGPP synthetase) (ggppsase) (geranylgeranyl diphosphate 0.0054 0.0353 0.0554
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0213 0.2542 0.406
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0041
Brugia malayi follicle stimulating hormone receptor 0.0532 0.6936 0.8151
Loa Loa (eye worm) hypothetical protein 0.0065 0.0506 0.0595
Loa Loa (eye worm) polyprenyl synthetase 0.0213 0.2542 0.299
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0065 0.0506 0.0595
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0085 0.006
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0043 0.0208 0.0193
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0054 0.0353 0.0338
Echinococcus granulosus thyroid hormone receptor alpha 0.0031 0.0034 0.0019
Brugia malayi Nuclear hormone receptor-like 1 0.0034 0.0085 0.006
Loa Loa (eye worm) hypothetical protein 0.0065 0.0506 0.0595
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0045 0.023 0.0215
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0065 0.0506 0.0595
Brugia malayi mbt repeat family protein 0.0049 0.029 0.0302
Brugia malayi MH2 domain containing protein 0.0319 0.4003 0.4687
Loa Loa (eye worm) hypothetical protein 0.0041 0.0183 0.0215
Schistosoma mansoni hypothetical protein 0.0487 0.6322 0.6309
Giardia lamblia Farnesyl diphosphate synthase 0.0213 0.2542 1
Brugia malayi intermediate filament protein 0.006 0.0446 0.0486
Brugia malayi hypothetical protein 0.0031 0.0044 0.0011
Schistosoma mansoni hypothetical protein 0.0039 0.0155 0.0121
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.029 0.043
Schistosoma mansoni myelin transcription factor 1 myt1 0.0056 0.0384 0.0351
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0056 0.0383 0.0368
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0065 0.0506 0.0491
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0054 0.0353 0.0415
Echinococcus granulosus lamin 0.006 0.0446 0.0431
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0041
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0054 0.0353 0.0338
Brugia malayi Pre-SET motif family protein 0.0407 0.5219 0.6123
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0031 0.0034 0.0019
Echinococcus multilocularis lamin dm0 0.006 0.0446 0.0431
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0041
Brugia malayi mbt repeat family protein 0.0049 0.029 0.0302
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0031 0.0034 0.0041
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0041
Loa Loa (eye worm) hypothetical protein 0.0048 0.028 0.0329
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0041 0.0183 0.0149
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0045 0.023 0.0215
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0418 0.0384
Echinococcus granulosus nuclear receptor nhr 48 0.0031 0.0034 0.0019
Brugia malayi photoreceptor-specific nuclear receptor 0.0065 0.0506 0.0557
Loa Loa (eye worm) steroid hormone receptor 0.0065 0.0506 0.0595
Schistosoma mansoni tar DNA-binding protein 0.0128 0.138 0.1351
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0058 0.0418 0.0384
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.029 0.0276
Schistosoma mansoni lamin 0.006 0.0446 0.0413
Schistosoma mansoni hypothetical protein 0.0056 0.0383 0.0349
Brugia malayi Polyprenyl synthetase family protein 0.0213 0.2542 0.2961
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0065 0.0506 0.0491
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0065 0.0506 0.0491
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.029 0.0276
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0066 0.0528 0.0513
Schistosoma mansoni glutathione synthetase 0.0054 0.0353 0.0319
Echinococcus granulosus tar DNA binding protein 0.0128 0.138 0.1367
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0058 0.0418 0.0996
Brugia malayi beta-lactamase 0.0041 0.0183 0.0175
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0045 0.023 0.0196
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0058 0.0418 0.0403
Schistosoma mansoni tar DNA-binding protein 0.0128 0.138 0.1351
Onchocerca volvulus 0.0065 0.0506 0.0791
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0065 0.0506 0.0491
Schistosoma mansoni hypothetical protein 0.0487 0.6322 0.6309
Loa Loa (eye worm) hypothetical protein 0.006 0.0446 0.0524
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0065 0.0506 0.0595
Brugia malayi beta-lactamase family protein 0.0041 0.0183 0.0175
Chlamydia trachomatis geranylgeranyl pyrophosphate synthase 0.0054 0.0353 0.5
Brugia malayi Pre-SET motif family protein 0.0058 0.0418 0.0453
Leishmania major solanesyl-diphosphate synthase, putative 0.0054 0.0353 0.072
Loa Loa (eye worm) hypothetical protein 0.0065 0.0506 0.0595
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0043 0.0208 0.0244
Brugia malayi RNA recognition motif domain containing protein 0.0128 0.138 0.159
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0045 0.023 0.0215
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.029 0.0257
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0041
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.029 0.0257
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0056 0.0388 0.0373
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0034 0.0085 0.0051
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0043 0.0208 0.0205
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0065 0.0506 0.0557
Schistosoma mansoni tar DNA-binding protein 0.0128 0.138 0.1351
Echinococcus granulosus farnesyl pyrophosphate synthase 0.0213 0.2542 0.253
Trypanosoma cruzi PAB1-binding protein , putative 0.0048 0.028 0.0411
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0194 0.2281 0.2269
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0054 0.0353 0.5
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0041 0.0183 0.0215
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0056 0.0384 0.0413
Onchocerca volvulus 0.0463 0.5993 1
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0213 0.2542 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0056 0.0383 0.0368
Echinococcus multilocularis musashi 0.006 0.0446 0.0431
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0208 0.0174
Loa Loa (eye worm) hypothetical protein 0.0078 0.0688 0.0809
Onchocerca volvulus Protein ultraspiracle homolog 0.0065 0.0506 0.0791
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0054 0.0353 0.0338
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0054 0.0353 0.072
Schistosoma mansoni tar DNA-binding protein 0.0128 0.138 0.1351
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.023 0.0081
Echinococcus granulosus histone lysine methyltransferase setb 0.0058 0.0418 0.0403
Wolbachia endosymbiont of Brugia malayi geranylgeranyl pyrophosphate synthase 0.0054 0.0353 0.5
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0031 0.0034 0.0019
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0056 0.0384 0.0369
Loa Loa (eye worm) TAR-binding protein 0.0128 0.138 0.1624
Trypanosoma cruzi PAB1-binding protein , putative 0.0048 0.028 0.0411
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0065 0.0506 0.0557
Brugia malayi Latrophilin receptor protein 2 0.0056 0.0383 0.0411
Loa Loa (eye worm) intermediate filament protein 0.006 0.0446 0.0524
Brugia malayi 3'5'-cyclic nucleotide phosphodiesterase family protein 0.0645 0.8501 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0056 0.0383 0.0411
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0054 0.0353 0.072
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.0213 0.2542 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0066 0.0528 0.1462
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.023 0.0199
Echinococcus multilocularis ubiquitin specific protease 41 0.0045 0.023 0.0215
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.023 0.0199
Brugia malayi Calcitonin receptor-like protein seb-1 0.0176 0.2044 0.2373
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0041 0.0183 0.0175
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0065 0.0506 0.0557
Loa Loa (eye worm) hypothetical protein 0.0121 0.1275 0.15
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0041
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.029 0.0257
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0065 0.0506 0.0595
Loa Loa (eye worm) hypothetical protein 0.0065 0.0506 0.0595
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.029 0.0276
Loa Loa (eye worm) polyprenyl synthetase 0.0054 0.0353 0.0415
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0034 0.0085 0.007
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0065 0.0506 0.0557
Echinococcus multilocularis FTZ F1 alpha 0.0065 0.0506 0.0491
Echinococcus granulosus survival motor neuron protein 1 0.0182 0.2117 0.2105
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0066 0.0528 0.1125
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0066 0.0528 0.0513
Loa Loa (eye worm) beta-lactamase 0.0041 0.0183 0.0215
Onchocerca volvulus 0.006 0.0446 0.069
Brugia malayi hypothetical protein 0.0048 0.028 0.029
Onchocerca volvulus 0.0078 0.0688 0.1096
Schistosoma mansoni nuclear hormone receptor 0.0065 0.0506 0.0473
Schistosoma mansoni lamin 0.006 0.0446 0.0413
Loa Loa (eye worm) transcription factor SMAD2 0.0319 0.4003 0.4709
Loa Loa (eye worm) hypothetical protein 0.0041 0.0183 0.0215
Loa Loa (eye worm) hypothetical protein 0.0041 0.0183 0.0215
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0043 0.0208 0.0174
Plasmodium vivax SET domain protein, putative 0.0058 0.0418 0.0996
Schistosoma mansoni thyroid hormone receptor 0.0065 0.0506 0.0473
Loa Loa (eye worm) hypothetical protein 0.0045 0.023 0.027
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0031 0.0034 0.0019
Trypanosoma cruzi polyprenyl synthase, putative 0.0054 0.0353 0.072
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0032 0.0059 0.007
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0065 0.0506 0.0491
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0031 0.0034 0.0019
Echinococcus multilocularis survival motor neuron protein 1 0.0182 0.2117 0.2105
Schistosoma mansoni hypothetical protein 0.0037 0.0124 0.009
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0065 0.0506 0.0491
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0045 0.023 0.0215
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.029 0.0276
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0065 0.0506 0.0491
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0041
Echinococcus granulosus histone acetyltransferase MYST2 0.0056 0.0384 0.0369
Brugia malayi latrophilin 2 splice variant baaae 0.0121 0.1275 0.1465
Echinococcus granulosus ecdysone induced protein 78C 0.0065 0.0506 0.0491
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0065 0.0506 0.0557
Onchocerca volvulus 0.0037 0.0124 0.0151
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0065 0.0506 0.0557
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0054 0.0353 0.0338
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0037 0.0124 0.0106
Trypanosoma brucei farnesyl pyrophosphate synthase 0.0213 0.2542 1
Brugia malayi Nuclear hormone receptor-like 1 0.0065 0.0506 0.0557
Schistosoma mansoni hypothetical protein 0.0056 0.0383 0.0349
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0041
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0407 0.5219 0.6139
Loa Loa (eye worm) hypothetical protein 0.0049 0.029 0.0342
Leishmania major polyprenyl synthase, putative 0.0054 0.0353 0.072
Onchocerca volvulus 0.0058 0.0418 0.0643
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0054 0.0353 1
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.0213 0.2542 1
Echinococcus granulosus lamin dm0 0.006 0.0446 0.0431
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.01
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0041
Schistosoma mansoni hypothetical protein 0.0299 0.3728 0.3706
Schistosoma mansoni thyroid hormone receptor 0.0065 0.0506 0.0473
Loa Loa (eye worm) hypothetical protein 0.0029 0.0015 0.0018
Schistosoma mansoni farnesyl pyrophosphate synthase 0.0213 0.2542 0.2516
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0065 0.0506 0.0557
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0065 0.0506 0.0473
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0043 0.0208 0.0193
Schistosoma mansoni hypothetical protein 0.0121 0.1275 0.1245
Echinococcus granulosus Nuclear hormone receptor HR96 0.0031 0.0034 0.0019
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0034 0.0085 0.01
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0065 0.0506 0.0491
Echinococcus multilocularis lamin 0.006 0.0446 0.0431
Loa Loa (eye worm) hypothetical protein 0.0059 0.0431 0.0506
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0058 0.0418 0.0403
Brugia malayi nuclear receptor NHR-88 0.0065 0.0506 0.0557
Loa Loa (eye worm) hypothetical protein 0.0065 0.0506 0.0595
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) 0.0213 0.2542 0.7694
Trichomonas vaginalis set domain proteins, putative 0.0463 0.5993 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0065 0.0506 0.0473
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0065 0.0506 0.0491
Echinococcus multilocularis geminin 0.0487 0.6322 0.6316
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0066 0.0528 0.1462
Brugia malayi beta-lactamase family protein 0.0041 0.0183 0.0175
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0128 0.138 0.1624
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.01
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0065 0.0506 0.0557
Echinococcus granulosus GPCR family 2 0.0056 0.0383 0.0368
Brugia malayi nuclear hormone receptor 0.0065 0.0506 0.0557
Toxoplasma gondii LsmAD domain-containing protein 0.0048 0.028 0.0411
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0054 0.0353 0.072
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0045 0.023 0.0081
Loa Loa (eye worm) hypothetical protein 0.0056 0.0383 0.045
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0045 0.023 0.3777
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0054 0.0353 0.0322
Echinococcus multilocularis microtubule associated protein 2 0.0754 1 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0034 0.0085 0.0051
Schistosoma mansoni steroid hormone receptor ad4bp 0.0065 0.0506 0.0473
Plasmodium vivax ataxin-2 like protein, putative 0.0048 0.028 0.0411
Loa Loa (eye worm) RNA binding protein 0.0128 0.138 0.1624
Echinococcus granulosus Nuclear hormone receptor HR96 0.0031 0.0034 0.0019
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0065 0.0506 0.0491
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0045 0.023 0.0196
Schistosoma mansoni coup transcription factor 0.0065 0.0506 0.0473
Trichomonas vaginalis conserved hypothetical protein 0.0045 0.023 0.0081
Echinococcus multilocularis GPCR, family 2 0.0056 0.0383 0.0368
Brugia malayi RNA binding protein 0.0128 0.138 0.159
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0045 0.023 0.0199
Trypanosoma cruzi polyprenyl synthase, putative 0.0054 0.0353 0.072
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0065 0.0506 0.0595
Brugia malayi ecdysteroid receptor 0.0442 0.5708 0.6701
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0054 0.0353 1
Schistosoma mansoni trans-prenyltransferase 0.0054 0.0353 0.0319
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0041
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0155 0.014
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0065 0.0506 0.0595
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0065 0.0506 0.0595
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0054 0.0353 0.0338
Loa Loa (eye worm) hypothetical protein 0.0442 0.5708 0.6714
Mycobacterium ulcerans polyprenyl diphosphate synthetase, GrcC1 0.0054 0.0353 0.072
Mycobacterium tuberculosis Possible polyprenyl synthetase IdsB (polyprenyl transferase) (polyprenyl diphosphate synthase) 0.0054 0.0353 0.0554
Loa Loa (eye worm) DR-78 0.0031 0.0034 0.0041
Onchocerca volvulus 0.0049 0.029 0.043
Onchocerca volvulus Bile acid receptor homolog 0.0442 0.5708 0.9521
Echinococcus multilocularis nuclear receptor nhr 48 0.0031 0.0034 0.0019
Treponema pallidum octaprenyl-diphosphate synthase 0.0054 0.0353 0.5
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0194 0.2281 0.2269
Loa Loa (eye worm) MBCTL1 0.0056 0.0384 0.0452
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0031 0.0034 0.0019
Schistosoma mansoni hypothetical protein 0.0056 0.0383 0.0349
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0054 0.0353 0.072
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0054 0.0353 0.0319
Loa Loa (eye worm) hypothetical protein 0.0041 0.0183 0.0215
Echinococcus granulosus FTZ F1 alpha 0.0065 0.0506 0.0491
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0054 0.0353 1
Onchocerca volvulus 0.0041 0.0183 0.0249
Loa Loa (eye worm) hypothetical protein 0.0065 0.0506 0.0595
Schistosoma mansoni tar DNA-binding protein 0.0128 0.138 0.1351
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.0213 0.2542 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0041 0.0183 0.0168
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0045 0.023 0.0199
Loa Loa (eye worm) hypothetical protein 0.0041 0.0183 0.0215
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0056 0.0384 0.0369
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0213 0.2542 1
Echinococcus multilocularis histone acetyltransferase MYST2 0.0056 0.0384 0.0369
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0054 0.0353 0.072
Loa Loa (eye worm) hypothetical protein 0.0645 0.8501 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.01
Trypanosoma brucei PAB1-binding protein , putative 0.0048 0.028 0.0411
Loa Loa (eye worm) hypothetical protein 0.0065 0.0506 0.0595
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0528 0.0495
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0041
Schistosoma mansoni aldehyde dehydrogenase 0.0066 0.0528 0.0495
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0065 0.0506 0.0557
Brugia malayi hypothetical protein 0.0039 0.0155 0.0143
Onchocerca volvulus 0.0041 0.0183 0.0249
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0041
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.0213 0.2542 0.253
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0176 0.2044 0.2373
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0065 0.0506 0.0491
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0031 0.0034 0.0019
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0056 0.0383 0.0368
Brugia malayi Polyprenyl synthetase family protein 0.0054 0.0353 0.0376
Echinococcus granulosus geminin 0.0487 0.6322 0.6316
Schistosoma mansoni retinoic acid receptor RXR 0.0065 0.0506 0.0473
Schistosoma mansoni intermediate filament proteins 0.006 0.0446 0.0413
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0065 0.0506 0.0791
Loa Loa (eye worm) hypothetical protein 0.0031 0.0034 0.0041
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0065 0.0506 0.0473
Toxoplasma gondii aldehyde dehydrogenase 0.0066 0.0528 0.1462
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase 0.0213 0.2542 1
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.0213 0.2542 0.406
Leishmania major hypothetical protein, conserved 0.0048 0.028 0.0411
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0065 0.0506 0.0473
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.01
Brugia malayi hypothetical protein 0.0034 0.0085 0.006
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0056 0.0383 0.0368
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0065 0.0506 0.0557
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0155 0.014
Echinococcus granulosus intermediate filament protein 0.006 0.0446 0.0431
Brugia malayi hypothetical protein 0.0182 0.2117 0.246
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0065 0.0506 0.0557
Brugia malayi TAR-binding protein 0.0128 0.138 0.159
Brugia malayi Steroid receptor seven-up type 2 0.0065 0.0506 0.0557
Schistosoma mansoni RAR-like nuclear receptor 0.0065 0.0506 0.0473
Onchocerca volvulus 0.006 0.0446 0.069
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0054 0.0353 0.0338
Loa Loa (eye worm) hypothetical protein 0.0182 0.2117 0.249
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0054 0.0353 1
Loa Loa (eye worm) hypothetical protein 0.0176 0.2044 0.2404
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.029 0.0342
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.0213 0.2542 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0065 0.0506 0.0491
Loa Loa (eye worm) hypothetical protein 0.0034 0.0085 0.01

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 25.929 uM PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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