Detailed information for compound 1718963

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 463.572 | Formula: C26H33N5O3
  • H donors: 0 H acceptors: 2 LogP: 2.83 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1n1cnc(c1)C)/C=C/1\CCCN2C1=NOC[C@@H]2CC(=O)N1CCCCC1
  • InChi: 1S/C26H33N5O3/c1-19-16-30(18-27-19)23-9-8-20(14-24(23)33-2)13-21-7-6-12-31-22(17-34-28-26(21)31)15-25(32)29-10-4-3-5-11-29/h8-9,13-14,16,18,22H,3-7,10-12,15,17H2,1-2H3/b21-13+/t22-/m0/s1
  • InChiKey: OZZJJWOEGIXICC-JFLYLQGUSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens APH1B gamma secretase subunit Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Brugia malayi gamma-secretase subunit aph-1 Get druggable targets OG5_130831 All targets in OG5_130831
Echinococcus granulosus gamma secretase subunit aph 1 Get druggable targets OG5_130831 All targets in OG5_130831
Schistosoma mansoni gamma-secretase subunit aph-1 Get druggable targets OG5_130831 All targets in OG5_130831
Echinococcus multilocularis gamma secretase subunit aph 1 Get druggable targets OG5_130831 All targets in OG5_130831
Schistosoma japonicum ko:K06172 anterior pharynx defective 1, putative Get druggable targets OG5_130831 All targets in OG5_130831
Loa Loa (eye worm) gamma-secretase subunit aph-1 Get druggable targets OG5_130831 All targets in OG5_130831
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0105 0.021
Entamoeba histolytica hypothetical protein 0.0037 0.0373 0.0816
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0159 0.0358
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.068 0.1929
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0048 0.0081
Onchocerca volvulus 0.0015 0.0105 0.021
Entamoeba histolytica hypothetical protein 0.0037 0.0373 0.0816
Leishmania major glucose transporter/membrane transporter D2, putative 0.0032 0.032 0.2436
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0007 0.0012 0.0022
Trichomonas vaginalis sugar transporter, putative 0.0032 0.032 0.0698
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.032 0.0698
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0105 0.021
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0012 0.0026
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0368 0.4431 1
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0371 0.2772
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0015 0.0105 0.0235
Chlamydia trachomatis proline--tRNA ligase 0.0011 0.006 0.0148
Onchocerca volvulus 0.024 0.2868 0.6464
Brugia malayi ATP dependent DNA ligase C terminal region family protein 0.001 0.0048 0.0107
Onchocerca volvulus 0.003 0.0296 0.0644
Trypanosoma cruzi hexose transporter, putative 0.0018 0.0141 0.1055
Echinococcus multilocularis 6 phosphofructokinase 0.011 0.1276 0.1265
Mycobacterium ulcerans hypothetical protein 0.0037 0.0373 0.0841
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0048 0.0081
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0167 0.0438
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.021 0.1565
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Plasmodium falciparum protein kinase 6 0.0441 0.533 1
Trichomonas vaginalis myo-inositol transporter, putative 0.0015 0.0105 0.021
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0105 0.021
Echinococcus multilocularis Niemann Pick C1 protein 0.0143 0.1674 0.1664
Brugia malayi AMP-binding enzyme family protein 0.0024 0.022 0.0496
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0134 0.0439
Trichomonas vaginalis set domain proteins, putative 0.024 0.2868 0.6464
Loa Loa (eye worm) hypothetical protein 0.0032 0.0315 0.0711
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.0904 0.2547
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0315 0.0304
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.029 0.0544
Loa Loa (eye worm) hypothetical protein 0.0024 0.022 0.0496
Echinococcus granulosus Protein patched homolog 1 0.0043 0.045 0.124
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.022 0.0724
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0007 0.0012 0.0026
Trypanosoma brucei glucose transporter 2A 0.0032 0.032 0.2395
Toxoplasma gondii ATPase, AAA family protein 0.001 0.0048 0.0135
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.1199 0.3358
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0368 0.4431 1
Echinococcus multilocularis gamma secretase subunit aph 1 0.0296 0.3547 0.3539
Trichomonas vaginalis conserved hypothetical protein 0.0104 0.1199 0.2686
Toxoplasma gondii exonuclease III APE 0.0019 0.0159 0.0451
Loa Loa (eye worm) hypothetical protein 0.0037 0.0373 0.0841
Mycobacterium ulcerans 6-phosphofructokinase 0.011 0.1276 0.2879
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0308 0.0866
Echinococcus multilocularis muscleblind protein 1 0.0152 0.1781 0.1771
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0373 0.1021
Leishmania major protein kinase, putative 0.0032 0.0315 0.2398
Mycobacterium ulcerans lipase LipD 0.0037 0.0373 0.0841
Loa Loa (eye worm) hypothetical protein 0.0031 0.0308 0.0693
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0235
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.0904 0.7056
Brugia malayi major facilitator superfamily protein 0.0015 0.0105 0.0235
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0007 0.0012 0.0026
Trichomonas vaginalis 6-phosphofructokinase, putative 0.003 0.029 0.063
Echinococcus multilocularis General substrate transporter 0.0089 0.102 0.1009
Plasmodium falciparum mitogen-activated protein kinase 2 0.0168 0.1983 0.372
Loa Loa (eye worm) hypothetical protein 0.0053 0.0569 0.1282
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.022 0.0496
Loa Loa (eye worm) hypothetical protein 0.0024 0.022 0.0496
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0159 0.0147
Onchocerca volvulus 0.0037 0.0373 0.0817
Schistosoma mansoni protein kinase 0.0032 0.0315 0.0888
Loa Loa (eye worm) hypothetical protein 0.008 0.0904 0.2039
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0373 0.105
Echinococcus multilocularis solute carrier family 22 0.0015 0.0105 0.0093
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1276 0.2861
Loa Loa (eye worm) hypothetical protein 0.0152 0.1781 0.402
Echinococcus granulosus 6 phosphofructokinase 0.011 0.1276 0.3576
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0315 0.0304
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0007 0.0012 0.0026
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0373 0.0361
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0296 0.0805
Brugia malayi CHE-14 protein 0.0043 0.045 0.1016
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.0904 1
Loa Loa (eye worm) gamma-secretase subunit aph-1 0.0296 0.3547 0.8005
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0315 0.0858
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0146 0.0272
Schistosoma mansoni ap endonuclease 0.0019 0.0159 0.0448
Onchocerca volvulus 0.0015 0.0105 0.021
Onchocerca volvulus 0.0368 0.4431 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0012 0.0026
Echinococcus granulosus Niemann Pick C1 protein 0.0143 0.1674 0.4701
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.032 0.2395
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.0904 0.2523
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Echinococcus multilocularis Niemann Pick C1 protein 0.01 0.1149 0.1138
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.003 0.029 0.0654
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0308 0.0866
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0007 0.0012 0.0026
Brugia malayi intermediate filament protein 0.0028 0.0263 0.0592
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.022 0.1672
Entamoeba histolytica protein kinase, putative 0.0032 0.0315 0.0687
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0032 0.0316 0.0895
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0235
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1276 0.2861
Echinococcus granulosus dna polymerase kappa 0.002 0.0167 0.0438
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0328
Schistosoma mansoni topbp1 0.001 0.0048 0.0134
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.022 0.1672
Trypanosoma brucei Aph-1 protein, putative 0.0115 0.1337 1
Plasmodium vivax CDK-related protein kinase 6, putative 0.0441 0.533 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0167 0.0351
Mycobacterium ulcerans NAD-dependent DNA ligase LigA 0.001 0.0048 0.0107
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0048 0.0081
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0167 0.1246
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0308 0.0836
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0235
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0107
Onchocerca volvulus 0.0037 0.0373 0.0817
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0371 0.2772
Echinococcus granulosus lamin 0.0028 0.0263 0.071
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0368 0.4431 1
Trypanosoma brucei glucose transporter, putative 0.0032 0.032 0.2395
Loa Loa (eye worm) sugar transporter 0.0104 0.1199 0.2705
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0904 0.2564
Schistosoma mansoni glucose transport protein 0.0104 0.1199 0.338
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.068 0.1889
Trypanosoma brucei unspecified product 0.0014 0.0092 0.0685
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0371 0.0695
Onchocerca volvulus 0.0015 0.0105 0.021
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0134 0.0439
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.2511 0.5667
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0167 0.1246
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.003 0.029 0.1975
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Echinococcus multilocularis muscleblind protein 0.0152 0.1781 0.1771
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.021 0.0448
Loa Loa (eye worm) hypothetical protein 0.0013 0.0082 0.0184
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0012 0.0088
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.022 0.0496
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0235
Plasmodium vivax sugar transporter, putative 0.0015 0.0105 0.0195
Onchocerca volvulus 0.0015 0.0105 0.021
Brugia malayi 6-phosphofructokinase 0.011 0.1276 0.2879
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.021 0.059
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0007 0.0012 0.004
Onchocerca volvulus 0.0015 0.0105 0.021
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0012 0.0026
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0235
Trypanosoma cruzi FHA domain containing protein, putative 0.001 0.0048 0.0355
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Trypanosoma cruzi hexose transporter, putative 0.0015 0.0105 0.0779
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0373 0.0841
Schistosoma mansoni glucose transporter 0.0015 0.0105 0.0294
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0015 0.0105 0.0344
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0371 0.2772
Schistosoma mansoni serine/threonine protein kinase 0.0032 0.0315 0.0888
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.022 0.0724
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.021 0.0198
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0263 0.1982
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0048 0.0081
Echinococcus multilocularis musashi 0.0028 0.0263 0.0251
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0032 0.0316 0.0591
Plasmodium vivax calcium-dependent protein kinase, putative 0.0032 0.0316 0.0591
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.022 0.0471
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0007 0.0012 0.004
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0308 0.0669
Loa Loa (eye worm) hypothetical protein 0.01 0.1149 0.2592
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.022 0.0496
Loa Loa (eye worm) hypothetical protein 0.0027 0.0257 0.0578
Leishmania major ATP-dependent phosphofructokinase 0.011 0.1276 0.9708
Onchocerca volvulus 0.0015 0.0105 0.021
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0048 0.0355
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0105 0.021
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0373 0.0841
Brugia malayi hypothetical protein 0.024 0.2863 0.6462
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0167 0.0376
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1276 0.2861
Toxoplasma gondii protein kinase, putative 0.0294 0.3523 1
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.0904 0.697
Leishmania major glucose transporter, lmgt2 0.0032 0.032 0.2436
Toxoplasma gondii hypothetical protein 0.0028 0.0263 0.0744
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Schistosoma mansoni lamin 0.0028 0.0263 0.074
Brugia malayi Sugar transporter family protein 0.0015 0.0105 0.0235
Mycobacterium ulcerans sugar transporter 0.0015 0.0105 0.0235
Leishmania major DNA polymerase kappa, putative 0.002 0.0167 0.1267
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.029 0.063
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.068 0.1916
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0007 0.0012 0.0026
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0368 0.4431 1
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0371 0.0695
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0167 0.1246
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0328
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0368 0.4431 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0107
Loa Loa (eye worm) hypothetical protein 0.002 0.0167 0.0376
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0048 0.0081
Schistosoma mansoni hypothetical protein 0.0173 0.2045 0.5766
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0167 0.1246
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0012 0.0026
Trypanosoma cruzi glucose transporter, putative 0.0015 0.0105 0.0779
Leishmania major hypothetical protein, conserved 0.0015 0.0105 0.0793
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0167 0.0351
Loa Loa (eye worm) hypothetical protein 0.0013 0.0088 0.0198
Loa Loa (eye worm) phosphofructokinase 0.011 0.1276 0.2879
Toxoplasma gondii 6-phosphofructokinase 0.003 0.029 0.0823
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.0904 0.0893
Loa Loa (eye worm) hypothetical protein 0.0024 0.022 0.0496
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.1314 0.9833
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.022 0.1646
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0315 0.0858
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0233 0.2783 0.915
Echinococcus granulosus solute carrier family 22 0.0015 0.0105 0.0262
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0159 0.0298
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0007 0.0012 0.0033
Giardia lamblia Sugar-proton symporter 0.0015 0.0105 0.0235
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0167 0.1246
Loa Loa (eye worm) bifunctional aminoacyl-tRNA synthetase 0.0013 0.0082 0.0185
Schistosoma mansoni survival motor neuron protein 0.0049 0.0525 0.1478
Schistosoma mansoni sugar transporter 0.0015 0.0105 0.0294
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0007 0.0012 0.004
Trypanosoma brucei glucose transporter, putative 0.0032 0.032 0.2395
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0134 0.0439
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0373 0.1226
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0296 0.0834
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0373 0.0817
Onchocerca volvulus 0.0024 0.022 0.0471
Toxoplasma gondii ABC1 family protein 0.0037 0.0373 0.1057
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0159 0.1301
Mycobacterium leprae Probable lysyl-tRNA synthase LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0167 0.1226
Plasmodium falciparum hexose transporter 0.0104 0.1199 0.2249
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0012 0.0026
Schistosoma mansoni topbp1 0.001 0.0048 0.0134
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0007 0.0012 0.0086
Brugia malayi gamma-secretase subunit aph-1 0.0296 0.3547 0.8005
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0235
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0373 0.102
Onchocerca volvulus 0.0015 0.0105 0.021
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Trypanosoma brucei unspecified product 0.0014 0.0092 0.0685
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0032 0.0316 0.0591
Leishmania major glucose transporter, lmgt3 0.0032 0.032 0.2436
Brugia malayi phosphofructokinase 0.011 0.1276 0.2879
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0012 0.0026
Echinococcus multilocularis survival motor neuron protein 1 0.024 0.2863 0.2855
Echinococcus multilocularis protein patched 0.0043 0.045 0.0439
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.0088 0.0076
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Echinococcus multilocularis solute carrier family 22 0.0015 0.0105 0.0093
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.021 0.0472
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0106 0.0239
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0373 0.0841
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0105 0.0235
Mycobacterium ulcerans acetyl-CoA synthetase 0.0007 0.0012 0.0026
Schistosoma mansoni hypothetical protein 0.0041 0.0432 0.1215
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0308 0.0693
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0373 0.2855
Trypanosoma brucei glucose transporter 1E 0.0032 0.032 0.2395
Plasmodium falciparum replication factor C subunit 1, putative 0.001 0.0048 0.0089
Trypanosoma brucei glucose transporter, putative 0.0032 0.032 0.2395
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.029 0.063
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0904 0.1695
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0026
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.068 0.1534
Loa Loa (eye worm) hypothetical protein 0.0013 0.0082 0.0184
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0012 0.0086
Plasmodium vivax SET domain protein, putative 0.003 0.0296 0.0555
Schistosoma mansoni glucose transport protein 0.0104 0.1199 0.338
Loa Loa (eye worm) hypothetical protein 0.0037 0.0373 0.0841
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0012 0.004
Echinococcus multilocularis expressed conserved protein 0.0094 0.1075 0.1064
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0092 0.0685
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0032 0.0315 0.0858
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0368 0.4431 1
Onchocerca volvulus 0.0028 0.0263 0.0568
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0032 0.0315 0.0711
Echinococcus multilocularis lamin 0.0028 0.0263 0.0251
Schistosoma mansoni 6-phosphofructokinase 0.011 0.1276 0.3597
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.1276 0.9546
Brugia malayi Pre-SET motif family protein 0.003 0.0296 0.0668
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.1199 0.1188
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0255 0.3042 1
Brugia malayi Muscleblind-like protein 0.0152 0.1781 0.402
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.1199 0.3358
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0904 0.2039
Brugia malayi beta-lactamase 0.0037 0.0373 0.0841
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.022 0.0471
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0296 0.0834
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0904 1
Trichomonas vaginalis glucose transporter, putative 0.0032 0.032 0.0698
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.029 0.2833
Echinococcus multilocularis nibrin 0.001 0.0048 0.0036
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.045 0.0992
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.1199 0.3358
Giardia lamblia DINP protein human, muc B family 0.002 0.0167 0.0376
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0373 0.0699
Echinococcus multilocularis dna polymerase eta 0.002 0.0167 0.0155
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0373 0.105
Echinococcus granulosus synaptic vesicle 2 protein 0.0015 0.0105 0.0262
Trichomonas vaginalis conserved hypothetical protein 0.0015 0.0105 0.021
Schistosoma mansoni 6-phosphofructokinase 0.011 0.1276 0.3597
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0113 0.1314 0.2947
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0049 0.0525 0.1183
Schistosoma mansoni hypothetical protein 0.0041 0.0432 0.1215
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0296 0.0834
Mycobacterium ulcerans integral membrane transport protein 0.0015 0.0105 0.0235
Mycobacterium ulcerans hypothetical protein 0.0024 0.022 0.0496
Trypanosoma brucei unspecified product 0.002 0.0167 0.1246
Trichomonas vaginalis chromosome transmission fidelity factor, putative 0.001 0.0048 0.0081
Onchocerca volvulus 0.0015 0.0105 0.021
Brugia malayi AMP-binding enzyme family protein 0.0024 0.022 0.0496
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0235
Brugia malayi beta-lactamase family protein 0.0037 0.0373 0.0841
Brugia malayi topoisomerase 0.001 0.0048 0.0107
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.021 0.059
Trypanosoma brucei glucose transporter, putative 0.0032 0.032 0.2395
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.022 0.0496
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0167 0.0376
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.011 0.1276 0.9546
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0167 0.0155
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0368 0.4431 1
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0315 0.0304
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0159 0.0523
Onchocerca volvulus Putative transporter 0.0015 0.0105 0.021
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0007 0.0012 0.0033
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0007 0.0012 0.004
Onchocerca volvulus 0.0015 0.0105 0.021
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0105 0.0235
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0012 0.0026
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0235
Onchocerca volvulus 0.001 0.0048 0.0081
Onchocerca volvulus 0.0049 0.0525 0.116
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0368 0.4431 1
Schistosoma mansoni intermediate filament proteins 0.0028 0.0263 0.074
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0328
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0235
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0015 0.0105 0.0195
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0032 0.0316 0.0895
Echinococcus granulosus expressed conserved protein 0.0094 0.1075 0.3006
Entamoeba histolytica hypothetical protein 0.001 0.0048 0.0081
Brugia malayi beta-lactamase family protein 0.0037 0.0373 0.0841
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0048 0.0355
Loa Loa (eye worm) hypothetical protein 0.003 0.0296 0.0668
Mycobacterium ulcerans DNA polymerase IV 0.002 0.0167 0.0376
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0107
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0032 0.0315 0.0304
Loa Loa (eye worm) hypothetical protein 0.0152 0.1781 0.402
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0007 0.0012 0.0026
Echinococcus granulosus intermediate filament protein 0.0028 0.0263 0.071
Brugia malayi DKFZp564C0469 protein 0.001 0.0048 0.0107
Schistosoma mansoni hypothetical protein 0.0104 0.1199 0.338
Trichomonas vaginalis glucose transporter, putative 0.0015 0.0105 0.021
Echinococcus multilocularis solute carrier family 22 0.0015 0.0105 0.0093
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0567 0.0555
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0308 0.0296
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.021 0.0559
Entamoeba histolytica hypothetical protein 0.0037 0.0373 0.0816
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0904 0.2564
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.068 0.0669
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Trypanosoma cruzi Aph-1 protein, putative 0.0115 0.1337 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.0373 0.0841
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0371 0.2819
Toxoplasma gondii sugar transporter ST3 0.0015 0.0105 0.0296
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0373 0.0817
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Schistosoma mansoni sugar transporter 0.0015 0.0105 0.0294
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0012 0.004
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0092 0.0685
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0167 0.1246
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.01 0.1149 0.2572
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0015 0.0105 0.0779
Plasmodium falciparum calcium-dependent protein kinase 3 0.0032 0.0316 0.0591
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.068 0.1916
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0105 0.0235
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0373 0.1226
Trichomonas vaginalis sugar transporter, putative 0.0032 0.032 0.0698
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0567 0.1863
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0007 0.0012 0.004
Brugia malayi Pax transcription activation domain interacting protein 0.001 0.0048 0.0107
Echinococcus multilocularis solute carrier family 22 0.0015 0.0105 0.0093
Trichomonas vaginalis sugar transporter, putative 0.0032 0.032 0.0698
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.001 0.0048 0.0134
Schistosoma mansoni DNA polymerase eta 0.002 0.0167 0.0469
Onchocerca volvulus 0.0015 0.0105 0.021
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0373 0.2787
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0373 0.0841
Toxoplasma gondii facilitative glucose transporter GT1 0.0104 0.1199 0.3402
Echinococcus granulosus solute carrier family 22 0.0015 0.0105 0.0262
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.021 0.0594
Echinococcus granulosus nibrin 0.001 0.0048 0.0101
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0007 0.0012 0.0026
Loa Loa (eye worm) hypothetical protein 0.0023 0.021 0.0472
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0107
Toxoplasma gondii phosphofructokinase domain-containing protein 0.003 0.029 0.0823
Trichomonas vaginalis esterase, putative 0.0037 0.0373 0.0817
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0373 0.0817
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.0175 0.0368
Echinococcus granulosus gamma secretase subunit aph 1 0.0296 0.3547 1
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0015 0.0105 0.0344
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0159 0.0358
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.022 0.0496
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.022 0.0496
Brugia malayi hypothetical protein 0.0015 0.0105 0.0235
Leishmania major hypothetical protein, conserved 0.0037 0.0373 0.2834
Echinococcus multilocularis synaptic vesicle 2 protein 0.0015 0.0105 0.0093
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0167 0.1246
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0328
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0134 0.0439
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.032 0.2395
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0159 0.0333
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0012 0.0086
Trypanosoma brucei THT1 - hexose transporter, putative 0.0032 0.032 0.2395
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0159 0.0333
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1276 0.2861
Echinococcus multilocularis protein dispatched 1 0.0049 0.0525 0.0513
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0146 0.0272
Plasmodium falciparum protein kinase 7 0.0294 0.3523 0.661
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.022 0.0496
Loa Loa (eye worm) hypothetical protein 0.0037 0.0373 0.0841
Echinococcus multilocularis dna polymerase kappa 0.002 0.0167 0.0155
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0373 0.2787
Trichomonas vaginalis sugar transport protein, putative 0.0015 0.0105 0.021
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0107
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0283 0.0766
Brugia malayi Cam kinase protein 1 0.0032 0.0315 0.0711
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0373 0.1226
Trypanosoma cruzi hexose transporter, putative 0.0032 0.032 0.2395
Brugia malayi Sugar transporter family protein 0.0104 0.1199 0.2705
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0904 0.2039
Loa Loa (eye worm) major facilitator superfamily transporter 0.0015 0.0105 0.0235
Plasmodium vivax acetyl-CoA synthetase, putative 0.0007 0.0012 0.0022
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.022 0.1672
Mycobacterium tuberculosis Conserved protein 0.0037 0.0373 0.1226
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0113 0.1314 0.2947
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1276 0.2861
Echinococcus multilocularis replication factor c subunit 1 0.001 0.0048 0.0036
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0235
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.003 0.029 0.0544
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0567 0.1863
Trypanosoma brucei DNA polymerase kappa, putative 0.0014 0.0092 0.0685
Brugia malayi Niemann-Pick C1 protein precursor 0.01 0.1149 0.2592
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0012 0.0026
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.068 0.5172
Toxoplasma gondii propionate-CoA ligase 0.0007 0.0012 0.0033
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0167 0.0469
Onchocerca volvulus 0.0015 0.0105 0.021
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0373 0.1049
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0007 0.0012 0.0026
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.011 0.1276 1
Trypanosoma cruzi BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0048 0.0355
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0048 0.0081
Leishmania major myo-inositol/proton symporter (MIT) 0.0015 0.0105 0.0793
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0308 0.0693
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0015 0.0105 0.0093
Trichomonas vaginalis phosphofructokinase, putative 0.011 0.1276 0.2861
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0373 0.0361
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0373 0.1226
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0007 0.0012 0.0026
Giardia lamblia Replication factor C, subunit 1 0.001 0.0048 0.0107
Loa Loa (eye worm) hypothetical protein 0.001 0.0048 0.0107
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0368 0.4431 1
Echinococcus multilocularis lamin dm0 0.0028 0.0263 0.0251
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.029 0.063
Onchocerca volvulus 0.0015 0.0105 0.021
Echinococcus granulosus Sugar transporter ERD6 protein 0.0015 0.0105 0.0262
Trypanosoma brucei glucose transporter, putative 0.0032 0.032 0.2395
Schistosoma mansoni sugar transporter 0.0015 0.0105 0.0294
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0104 0.1199 0.1188
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0167 0.0376
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0015 0.0105 0.0663
Loa Loa (eye worm) hypothetical protein 0.0037 0.0373 0.0841
Schistosoma mansoni protein kinase 0.0032 0.0315 0.0888
Loa Loa (eye worm) hypothetical protein 0.0007 0.0012 0.0026
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0235
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0235
Loa Loa (eye worm) hypothetical protein 0.0043 0.045 0.1016
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0012 0.0086
Toxoplasma gondii transporter, major facilitator family protein 0.0015 0.0105 0.0296
Onchocerca volvulus 0.0015 0.0105 0.021
Brugia malayi 6-phosphofructokinase 0.011 0.1276 0.2879
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0368 0.4431 1
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.003 0.029 0.063
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.002 0.0167 0.0549
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0159 0.1188
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.021 0.0472
Schistosoma mansoni hypothetical protein 0.0037 0.0373 0.1049
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.1199 0.1188
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0012 0.0026
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0159 0.1188
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.029 0.0544
Schistosoma mansoni ap endonuclease 0.0019 0.0159 0.0448
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0167 0.0376
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0159 0.0907
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0104 0.1199 0.1188
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.002 0.0167 0.0549
Echinococcus granulosus solute carrier family 22 0.0015 0.0105 0.0262
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0106 0.0239
Onchocerca volvulus 0.0015 0.0105 0.021
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0159 0.0358
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0146 0.1142
Brugia malayi major facilitator superfamily protein 0.0015 0.0105 0.0235
Schistosoma mansoni lamin 0.0028 0.0263 0.074
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0371 0.2819
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.003 0.0296 0.0285
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0167 0.0469
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Plasmodium vivax hexose transporter 0.0104 0.1199 0.2249
Plasmodium falciparum calcium-dependent protein kinase 5 0.0032 0.0316 0.0591
Trypanosoma cruzi Aph-1 protein, putative 0.0115 0.1337 1
Echinococcus multilocularis geminin 0.0173 0.2045 0.2036
Plasmodium falciparum calcium-dependent protein kinase 4 0.0032 0.0316 0.0591
Trypanosoma cruzi hexose transporter, putative 0.0032 0.032 0.2395
Plasmodium vivax 6-phosphofructokinase, putative 0.003 0.029 0.0544
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0032 0.0316 0.0591
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Schistosoma mansoni hypothetical protein 0.0173 0.2045 0.5766
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0373 0.0817
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0368 0.4431 1
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.1276 0.2879
Schistosoma mansoni gamma-secretase subunit aph-1 0.0296 0.3547 1
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Entamoeba histolytica protein kinase, putative 0.0032 0.0315 0.0687
Trichomonas vaginalis replication factor C large subunit, putative 0.001 0.0048 0.0081
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0159 0.0333
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0373 0.0817
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0567 0.4389
Trypanosoma brucei sugar transporter, putative 0.0015 0.0105 0.0779
Onchocerca volvulus 0.0015 0.0105 0.021
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Echinococcus granulosus General substrate transporter 0.0089 0.102 0.2851
Mycobacterium ulcerans beta-lactamase 0.0037 0.0373 0.0841
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Schistosoma mansoni chromosome transmission fidelity factor 0.001 0.0048 0.0134
Echinococcus granulosus calcium dependent protein kinase 0.003 0.0291 0.079
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.021 0.0472
Schistosoma mansoni hypothetical protein 0.0041 0.0432 0.1215
Loa Loa (eye worm) hypothetical protein 0.0037 0.0373 0.0841
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0032 0.0315 0.2358
Onchocerca volvulus 0.0028 0.0263 0.0568
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0012 0.0026
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Toxoplasma gondii phosphofructokinase PFKII 0.003 0.029 0.0823
Schistosoma mansoni sugar transporter 0.0015 0.0105 0.0294
Loa Loa (eye worm) hypothetical protein 0.0028 0.0263 0.0592
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0168 0.1983 0.372
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0167 0.1246
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0235
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0368 0.4431 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0012 0.004
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.068 0.1534
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0263 0.0592
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0263 0.0592
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0167 0.1246
Brugia malayi Sugar transporter family protein 0.0015 0.0105 0.0235
Leishmania major DNA polymerase eta, putative 0.002 0.0167 0.1267
Loa Loa (eye worm) sugar transporter 0.0015 0.0105 0.0235
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0263 0.0492
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0371 0.1051
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.022 0.0471
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0012 0.0088
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.029 0.063
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0032 0.0315 0.0711
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0043 0.045 0.1016
Plasmodium vivax replication factor C subunit 1, putative 0.001 0.0048 0.0089
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0012 0.0026
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0167 0.1246
Plasmodium falciparum calcium-dependent protein kinase 2 0.0032 0.0316 0.0591
Echinococcus granulosus sterol regulatory element binding protein 0.0043 0.045 0.124
Leishmania major hypothetical protein, conserved 0.0113 0.1314 1
Echinococcus granulosus muscleblind protein 0.0152 0.1781 0.5006
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.029 0.063
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0159 0.1208
Schistosoma mansoni hypothetical protein 0.0049 0.0525 0.1478
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Brugia malayi hypothetical protein 0.001 0.0048 0.0107
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0159 0.0416
Entamoeba histolytica hypothetical protein 0.0023 0.021 0.0448
Trypanosoma cruzi hexose transporter, putative 0.0032 0.032 0.2395
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0007 0.0012 0.0086
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0373 0.2787
Entamoeba histolytica phosphofructokinase, putative 0.011 0.1276 0.2861
Schistosoma mansoni DNA ligase IV 0.001 0.0048 0.0134
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.022 0.1646
Mycobacterium ulcerans prolyl-tRNA synthetase 0.0011 0.006 0.0135
Trichomonas vaginalis CAMK family protein kinase 0.0032 0.0315 0.0687
Trypanosoma cruzi DNA polymerase eta, putative 0.002 0.0167 0.1246
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0235
Echinococcus multilocularis sterol regulatory element binding protein 0.0043 0.045 0.0439
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.011 0.1276 0.4195
Brugia malayi hypothetical protein 0.001 0.0048 0.0107
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0007 0.0012 0.004
Schistosoma mansoni hypothetical protein 0.0041 0.0432 0.1215
Onchocerca volvulus 0.0015 0.0105 0.021
Trichomonas vaginalis glucose transporter, putative 0.0032 0.032 0.0698
Echinococcus granulosus survival motor neuron protein 1 0.024 0.2863 0.8067
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0007 0.0012 0.0086
Leishmania major glucose transporter, lmgt1 0.0032 0.032 0.2436
Trypanosoma brucei glucose transporter, putative 0.0032 0.032 0.2395
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0567 0.1569
Entamoeba histolytica deoxycytidyl transferase, putative 0.002 0.0167 0.0351
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0167 0.1246
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.011 0.1276 1
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0015 0.0105 0.0235
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0308 0.0669
Brugia malayi AMP-binding enzyme family protein 0.0024 0.022 0.0496
Echinococcus granulosus solute carrier family 22 0.0015 0.0105 0.0262
Mycobacterium ulcerans acyl-CoA synthetase 0.0007 0.0012 0.0026
Trypanosoma brucei glucose transporter, putative 0.0032 0.032 0.2395
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0167 0.1246
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.002 0.0167 0.1267
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0263 0.0592
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.032 0.0698
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0167 0.1246
Toxoplasma gondii sugar transporter ST2 0.0015 0.0105 0.0296
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.021 0.1567
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0146 0.0328
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0373 0.1226
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0032 0.0315 0.0711
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0296 0.084
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0373 0.1226
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0167 0.1246
Mycobacterium tuberculosis Conserved protein 0.0037 0.0373 0.1226
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0159 0.0298
Echinococcus granulosus replication factor c subunit 1 0.001 0.0048 0.0101
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0146 0.0479
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0032 0.0316 0.0895
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0113 0.1314 0.9833
Echinococcus granulosus geminin 0.0173 0.2045 0.5752
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0904 0.1695
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.021 0.0393
Loa Loa (eye worm) 6-phosphofructokinase 0.011 0.1276 0.2879
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0048 0.0081
Leishmania major acetyl-CoA synthetase, putative 0.0007 0.0012 0.0088
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0168 0.1983 0.5628
Brugia malayi Major Facilitator Superfamily protein 0.0015 0.0105 0.0235
Echinococcus granulosus Niemann Pick C1 protein 0.01 0.1149 0.3216
Trypanosoma brucei glucose transporter, putative 0.0032 0.032 0.2395
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0904 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.068 0.1534
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0328
Trichomonas vaginalis phosphofructokinase, putative 0.003 0.029 0.063
Schistosoma mansoni glucose transport protein 0.0104 0.1199 0.338
Plasmodium falciparum calcium-dependent protein kinase 1 0.0032 0.0316 0.0591
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0308 0.0693
Loa Loa (eye worm) hypothetical protein 0.0031 0.0308 0.0693
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0007 0.0012 0.004
Brugia malayi lysyl-tRNA synthetase 0.0023 0.021 0.0472
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.021 0.1567
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0159 0.0358
Echinococcus multilocularis calcium dependent protein kinase 0.003 0.0291 0.028
Trypanosoma cruzi hypothetical protein, conserved 0.0113 0.1314 0.9833
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0032 0.0315 0.0858
Brugia malayi hypothetical protein 0.0015 0.0105 0.0235
Brugia malayi AMP-binding enzyme family protein 0.0007 0.0012 0.0026
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.021 0.1593
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.021 0.1892
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0296 0.0834
Entamoeba histolytica Activator 1 140 kDa subunit, putative 0.001 0.0048 0.0081
Trichomonas vaginalis RNA polymerase II ctd phosphatase, putative 0.001 0.0048 0.0081
Loa Loa (eye worm) hypothetical protein 0.0025 0.0236 0.0532
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.021 0.0393
Treponema pallidum prolyl-tRNA synthetase 0.0011 0.006 0.0103
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0101 0.1168 0.3291
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0007 0.0012 0.004
Echinococcus granulosus dna polymerase eta 0.002 0.0167 0.0438
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.0088 0.0216
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.068 0.2235
Loa Loa (eye worm) oxidoreductase 0.0007 0.0012 0.0026
Trypanosoma brucei BRCA1 C Terminus (BRCT) domain containing protein, putative 0.001 0.0048 0.0355
Trypanosoma cruzi DNA polymerase kappa, putative 0.002 0.0167 0.1246
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0263 0.0492
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0167 0.1246
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0104 0.1199 0.3358
Brugia malayi hypothetical protein 0.0037 0.0373 0.084
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0007 0.0012 0.0026
Loa Loa (eye worm) hypothetical protein 0.024 0.2863 0.6462
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0015 0.0105 0.0294
Schistosoma mansoni patched 1 0.0043 0.045 0.1269
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0167 0.1246
Trypanosoma cruzi sugar transporter, putative 0.0015 0.0105 0.0779
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0308 0.2338
Toxoplasma gondii sugar transporter ST1 0.0015 0.0105 0.0296
Mycobacterium tuberculosis Conserved protein 0.0037 0.0373 0.1226
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0159 0.1188
Schistosoma mansoni acetyl-CoA synthetase 0.0007 0.0012 0.0033
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0007 0.0012 0.0026
Mycobacterium leprae Probable lipase LipE 0.0037 0.0373 0.2855
Onchocerca volvulus 0.0037 0.0373 0.0817
Brugia malayi Pre-SET motif family protein 0.0211 0.2511 0.5667
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0.0167 0.0549
Echinococcus granulosus lamin dm0 0.0028 0.0263 0.071
Giardia lamblia Hexose transporter 0.0015 0.0105 0.0235
Brugia malayi hypothetical protein 0.0015 0.0105 0.0235
Brugia malayi Probable ClpP-like protease 0.008 0.0904 0.2039
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0.0167 0.0549
Trypanosoma cruzi hexose transporter 0.0032 0.032 0.2395
Loa Loa (eye worm) beta-lactamase 0.0037 0.0373 0.0841
Trichomonas vaginalis sugar transporter, putative 0.0015 0.0105 0.021
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0263 0.1748
Entamoeba histolytica hypothetical protein 0.0037 0.0373 0.0816
Schistosoma mansoni protein kinase 0.0032 0.0315 0.0888
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.003 0.029 0.2833
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0373 0.1226
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0167 0.1246
Mycobacterium leprae PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) 0.001 0.0048 0.0283
Loa Loa (eye worm) hypothetical protein 0.0015 0.0105 0.0235
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0296 0.0285

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 1500 nM Modulation of gamma-secretase expressed in HEK293 cells co-expressing APPsw-lon assessed as reduction of amyloid-beta-42 level by sandwich immunoassay ChEMBL. 24900409

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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