TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 424.533 | Formula: C25H32N2O4
H donors: 2 H acceptors: 2 LogP: 2.95 Rotable bonds: 9
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc2c(cc1OC)CC(C2=O)CCCCCN[C@H]1CCCc2c1ccc(=O)[nH]2
InChi: 1S/C25H32N2O4/c1-30-22-14-17-13-16(25(29)19(17)15-23(22)31-2)7-4-3-5-12-26-20-8-6-9-21-18(20)10-11-24(28)27-21/h10-11,14-16,20,26H,3-9,12-13H2,1-2H3,(H,27,28)/t16?,20-/m0/s1
InChiKey: FYEUWJWPCZJKLN-FZCLLLDFSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	cell adhesion molecule	0.0415	0.0165	0.0165
Echinococcus multilocularis	roundabout 2	0.0528	0.0256	0.0256
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.0462	0.0202	0.0202
Trypanosoma brucei	N-myristoyltransferase	1.2741	1	1
Loa Loa (eye worm)	hypothetical protein	0.0668	0.0367	0.0367
Onchocerca volvulus		0.0418	0.0168	0.0253
Loa Loa (eye worm)	hypothetical protein	0.0668	0.0367	0.0367
Echinococcus granulosus	pdz domain containing protein	0.0668	0.0367	0.0367
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.032	0.0089	0.0089
Loa Loa (eye worm)	toll and interleukin 1 receptor domain-containing protein isoform f	0.0668	0.0367	0.0367
Brugia malayi	Shank2E	0.0668	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0668	0.0367	0.0367
Echinococcus multilocularis	sterile alpha and tir motif containing protein	0.0668	0.0367	0.0367
Schistosoma mansoni	titin	0.0415	0.0165	0.0165
Schistosoma mansoni	factor for adipocyte differentiation	0.032	0.0089	0.0089
Echinococcus granulosus	sterile alpha and tir motif containing protein	0.0668	0.0367	0.0367
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0465	0.0205	0.0205
Brugia malayi	hypothetical protein	0.032	0.0089	0.0089
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0415	0.0165	0.0165
Echinococcus granulosus	Fibronectin type III	0.032	0.0089	0.0089
Schistosoma mansoni	Protein aveugle	0.0668	0.0367	0.0367
Echinococcus granulosus	anosmin 1	0.032	0.0089	0.0089
Echinococcus granulosus	G1Y162 protein	0.032	0.0089	0.0089
Echinococcus granulosus	epidermal growth factor receptor	0.9908	0.7739	0.7739
Echinococcus multilocularis	transfer RNA-Phe	0.0415	0.0165	0.0165
Loa Loa (eye worm)	hypothetical protein	0.032	0.0089	0.0089
Echinococcus granulosus	Immunoglobulin	0.0348	0.0112	0.0112
Brugia malayi	hypothetical protein	0.0668	0.0367	0.0367
Plasmodium vivax	cysteine repeat modular protein 1, putative	0.0922	0.0569	0.0063
Brugia malayi	myotactin form A	0.032	0.0089	0.0089
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0415	0.0165	0.0165
Echinococcus multilocularis	epidermal growth factor receptor	0.9908	0.7739	0.7739
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0415	0.0165	0.0165
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.032	0.0089	0.0089
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0415	0.0165	0.0165
Loa Loa (eye worm)	AIDA-1b	0.0668	0.0367	0.0367
Toxoplasma gondii	GCC2 and GCC3 domain-containing protein	0.0922	0.0569	0.0963
Onchocerca volvulus		0.0668	0.0367	0.0554
Schistosoma mansoni	ephrin receptor	0.8688	0.6766	0.6766
Echinococcus granulosus	fibronectin type III domain-containing protein	0.032	0.0089	0.0089
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.5803	0.4464	0.4464
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.032	0.0089	0.0089
Brugia malayi	SPRY domain containing protein	0.032	0.0089	0.0089
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0528	0.0256	0.0256
Loa Loa (eye worm)	hypothetical protein	0.021	0.0001	0.0001
Echinococcus multilocularis	neuroglian	0.0528	0.0256	0.0256
Loa Loa (eye worm)	projectin	0.0415	0.0165	0.0165
Loa Loa (eye worm)	hypothetical protein	0.032	0.0089	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0922	0.0569	0.0569
Echinococcus multilocularis	peroxidasin	0.021	0.0001	0.0001
Schistosoma mansoni	tyrosine kinase	0.0386	0.0142	0.0142
Echinococcus granulosus	basic fibroblast growth factor receptor 1 A	0.037	0.0129	0.0129
Echinococcus multilocularis	titin	0.032	0.0089	0.0089
Schistosoma mansoni	tyrosine kinase	0.5202	0.3985	0.3985
Plasmodium vivax	hypothetical protein, conserved	0.0922	0.0569	0.0063
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0528	0.0256	0.0256
Echinococcus granulosus	Down syndrome cell adhesion molecule	0.0434	0.018	0.018
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0532	0.0258	0.0258
Echinococcus granulosus	defective proboscis extension response	0.0348	0.0112	0.0112
Brugia malayi	Lethal protein 805	0.032	0.0089	0.0089
Echinococcus multilocularis	basic fibroblast growth factor receptor 1 A	0.037	0.0129	0.0129
Schistosoma mansoni	cell adhesion molecule	0.0415	0.0165	0.0165
Schistosoma mansoni	prolyl 4-hydroxylase alpha subunit 1	0.026	0.0042	0.0042
Echinococcus multilocularis	Netrin receptor DCC	0.032	0.0089	0.0089
Schistosoma mansoni	cell adhesion molecule	0.0782	0.0458	0.0458
Loa Loa (eye worm)	hypothetical protein	0.851	0.6624	0.6624
Echinococcus granulosus	peroxidasin	0.021	0.0001	0.0001
Loa Loa (eye worm)	CAMK protein kinase	0.0418	0.0168	0.0168
Onchocerca volvulus		0.0922	0.0569	0.086
Loa Loa (eye worm)	hypothetical protein	0.4331	0.3289	0.3289
Onchocerca volvulus		0.032	0.0089	0.0135
Echinococcus granulosus	ephrin type A receptor 4 A	0.961	0.7501	0.7501
Echinococcus multilocularis	roundabout 2	0.0528	0.0256	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0668	0.0367	0.0367
Brugia malayi	Fibronectin type III domain containing protein	0.032	0.0089	0.0089
Echinococcus multilocularis	polyhomeotic proximal chromatin protein	0.0668	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0668	0.0367	0.0367
Loa Loa (eye worm)	TKL/LRRK protein kinase	0.1229	0.0815	0.0815
Loa Loa (eye worm)	TK/EPH protein kinase	1.1021	0.8627	0.8627
Echinococcus multilocularis	receptor type tyrosine protein phosphatase protein tyrosine phosphatase receptor type	0.032	0.0089	0.0089
Trypanosoma brucei	N-myristoyl transferase, putative	1.2741	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0415	0.0165	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0348	0.0112	0.0112
Onchocerca volvulus		0.032	0.0089	0.0135
Brugia malayi	Fibronectin type III domain containing protein	0.0668	0.0367	0.0367
Onchocerca volvulus		0.0668	0.0367	0.0554
Loa Loa (eye worm)	hypothetical protein	0.0922	0.0569	0.0569
Echinococcus granulosus	glycylpeptide N tetradecanoyltransferase	1.2741	1	1
Loa Loa (eye worm)	TK/ROR protein kinase	0.0273	0.0051	0.0051
Echinococcus granulosus	leucine rich repeat serine:threonine protein	0.1238	0.0821	0.0821
Plasmodium vivax	cysteine repeat modular protein 2, putative	0.0922	0.0569	0.0063
Echinococcus granulosus	anosmin 1	0.032	0.0089	0.0089
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.032	0.0089	0.0048
Onchocerca volvulus		0.851	0.6624	1
Onchocerca volvulus		0.0668	0.0367	0.0554
Echinococcus granulosus	Netrin receptor DCC	0.032	0.0089	0.0089
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0528	0.0256	0.0256
Echinococcus granulosus	roundabout 2	0.0877	0.0533	0.0533
Schistosoma mansoni	hemicentin	0.0415	0.0165	0.0165
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0668	0.0367	0.0367
Loa Loa (eye worm)	N-myristoyltransferase 2	1.2741	1	1
Brugia malayi	Immunoglobulin I-set domain containing protein	0.5803	0.4464	0.4464
Echinococcus multilocularis	fibroblast growth factor receptor 4	0.037	0.0129	0.0129
Schistosoma mansoni	tripartite motif protein trim9	0.032	0.0089	0.0089
Echinococcus multilocularis	receptor type tyrosine protein phosphatase	0.0528	0.0256	0.0256
Onchocerca volvulus		0.0668	0.0367	0.0554
Echinococcus multilocularis	titin	0.0418	0.0168	0.0168
Schistosoma mansoni	tyrosine kinase	0.9908	0.7739	0.7739
Schistosoma mansoni	titin	0.0418	0.0168	0.0168
Loa Loa (eye worm)	TK/INSR protein kinase	0.3249	0.2427	0.2427
Brugia malayi	coiled-coil like protein 1	0.0668	0.0367	0.0367
Echinococcus multilocularis	receptor type tyrosine protein phosphatase zeta	0.032	0.0089	0.0089
Brugia malayi	GCC2 and GCC3 family protein	0.0922	0.0569	0.0569
Plasmodium vivax	hypothetical protein, conserved	0.0922	0.0569	0.0063
Echinococcus granulosus	titin	0.0418	0.0168	0.0168
Loa Loa (eye worm)	hypothetical protein	0.1426	0.0972	0.0972
Echinococcus multilocularis	pdz domain containing protein	0.0668	0.0367	0.0367
Schistosoma mansoni	serine/threonine protein kinase	0.0418	0.0168	0.0168
Schistosoma mansoni	sex comb on midleg homolog	0.0668	0.0367	0.0367
Brugia malayi	protein unc-22	0.0418	0.0168	0.0168
Echinococcus multilocularis	fibronectin type III domain-containing protein	0.032	0.0089	0.0089
Schistosoma mansoni	tyrosine kinase	0.037	0.0129	0.0129
Plasmodium vivax	glycylpeptide N-tetradecanoyltransferase, putative	1.2741	1	1
Loa Loa (eye worm)	hypothetical protein	0.032	0.0089	0.0089
Echinococcus granulosus	histone acetyltransferase myst3	0.0668	0.0367	0.0367
Onchocerca volvulus		0.032	0.0089	0.0135
Echinococcus multilocularis	Down syndrome cell adhesion molecule	0.0434	0.018	0.018
Brugia malayi	Protein kinase domain containing protein	0.3249	0.2427	0.2427
Onchocerca volvulus	Tyrosine kinase homolog	0.5437	0.4172	0.6298
Echinococcus granulosus	Sterile alpha motif SAM	0.0668	0.0367	0.0367
Loa Loa (eye worm)	lethal protein 805	0.032	0.0089	0.0089
Toxoplasma gondii	oxidoreductase, 2OG-Fe(II) oxygenase family protein	0.7129	0.5522	1
Brugia malayi	protein-tyrosine phosphatase Lar-like precursor, putative	0.032	0.0089	0.0089
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.032	0.0089	0.0089
Echinococcus multilocularis	anosmin 1	0.032	0.0089	0.0089
Echinococcus granulosus	endonuclease reverse transcriptase	0.0922	0.0569	0.0569
Brugia malayi	GCC2 and GCC3 family protein	0.0922	0.0569	0.0569
Echinococcus granulosus	tyrosine protein kinase transmembrane receptor	0.0273	0.0051	0.0051
Onchocerca volvulus	Tankyrase homolog	0.0668	0.0367	0.0554
Echinococcus granulosus	polyhomeotic protein 2	0.0668	0.0367	0.0367
Brugia malayi	prolyl 4-hydroxylase	0.026	0.0042	0.0042
Schistosoma mansoni	N-myristoyltransferase	1.2741	1	1
Trypanosoma brucei	SAM domain (Sterile alpha motif), putative	0.0668	0.0367	0.0327
Echinococcus multilocularis	receptor type tyrosine protein phosphatase F	0.0528	0.0256	0.0256
Schistosoma mansoni	hypothetical protein	0.032	0.0089	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0668	0.0367	0.0367
Echinococcus granulosus	usherin	0.032	0.0089	0.0089
Loa Loa (eye worm)	hypothetical protein	0.032	0.0089	0.0089
Echinococcus multilocularis	cell adhesion molecule	0.032	0.0089	0.0089
Echinococcus granulosus	roundabout 2	0.0528	0.0256	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0668	0.0367	0.0367
Echinococcus granulosus	anosmin 1	0.032	0.0089	0.0089
Echinococcus multilocularis	Sterile alpha motif type	0.0668	0.0367	0.0367
Echinococcus multilocularis	neuroglian	0.0443	0.0187	0.0187
Trypanosoma cruzi	N-myristoyl transferase, putative	1.2741	1	1
Loa Loa (eye worm)	hypothetical protein	0.0668	0.0367	0.0367
Brugia malayi	Liprin-alpha 2	0.0668	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.032	0.0089	0.0089
Brugia malayi	bicaudal-C	0.0668	0.0367	0.0367
Giardia lamblia	Hypothetical protein	0.0922	0.0569	0.021
Echinococcus multilocularis	glycylpeptide N tetradecanoyltransferase	1.2741	1	1
Echinococcus multilocularis	usherin	0.032	0.0089	0.0089
Schistosoma mansoni	Neurotrimin precursor (hNT)	0.0348	0.0112	0.0112
Echinococcus granulosus	cell adhesion molecule	0.032	0.0089	0.0089
Echinococcus granulosus	prolyl 4 hydroxylase subunit alpha 1	0.026	0.0042	0.0042
Loa Loa (eye worm)	prolyl 4-hydroxylase 2	0.026	0.0042	0.0042
Loa Loa (eye worm)	myotactin form A	0.032	0.0089	0.0089
Loa Loa (eye worm)	hypothetical protein	0.032	0.0089	0.0089
Echinococcus multilocularis	Fibronectin, type III	0.032	0.0089	0.0089
Onchocerca volvulus		0.5164	0.3954	0.597
Brugia malayi	Protein-tyrosine phosphatase	0.032	0.0089	0.0089
Trypanosoma cruzi	hypothetical protein	0.0668	0.0367	0.0327
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0415	0.0165	0.0165
Loa Loa (eye worm)	hypothetical protein	0.032	0.0089	0.0089
Echinococcus granulosus	epidermal growth factor receptor	0.538	0.4127	0.4127
Trichomonas vaginalis	N-myristoyl transferase, putative	1.2741	1	1
Echinococcus multilocularis	anosmin 1	0.032	0.0089	0.0089
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0415	0.0165	0.0165
Leishmania major	hypothetical protein, conserved	0.032	0.0089	0.0048
Echinococcus multilocularis	ephrin type A receptor 4 A	0.961	0.7501	0.7501
Schistosoma mansoni	vesicular amine transporter	0.0369	0.0128	0.0128
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.032	0.0089	0.0089
Brugia malayi	GCC2 and GCC3 family protein	0.0922	0.0569	0.0569
Leishmania major	N-myristoyl transferase, putative	1.2741	1	1
Echinococcus multilocularis	epidermal growth factor receptor	0.538	0.4127	0.4127
Entamoeba histolytica	protein kinase, putative	0.0925	0.0572	0.0003
Echinococcus granulosus	Sterile alpha motif type	0.0668	0.0367	0.0367
Echinococcus granulosus	roundabout 2	0.0528	0.0256	0.0256
Schistosoma mansoni	phd finger protein	0.0668	0.0367	0.0367
Brugia malayi	cask-interacting protein 2	0.0668	0.0367	0.0367
Onchocerca volvulus		0.0668	0.0367	0.0554
Echinococcus multilocularis	Immunoglobulin	0.0348	0.0112	0.0112
Echinococcus multilocularis	basement membrane specific heparan sulfate	0.0348	0.0112	0.0112
Echinococcus granulosus	Netrin receptor DCC	0.032	0.0089	0.0089
Brugia malayi	Fibronectin type III domain containing protein	0.032	0.0089	0.0089
Trypanosoma cruzi	Fibronectin type III domain containing protein, putative	0.032	0.0089	0.0048
Brugia malayi	Fibronectin type III domain containing protein	0.032	0.0089	0.0089
Loa Loa (eye worm)	tnks protein	0.0668	0.0367	0.0367
Echinococcus multilocularis		0.3029	0.2251	0.2251
Onchocerca volvulus		0.0668	0.0367	0.0554
Echinococcus granulosus	neuroglian	0.0443	0.0187	0.0187
Schistosoma mansoni	lip-related protein (liprin) alpha	0.0668	0.0367	0.0367
Loa Loa (eye worm)	CAMK/MLCK protein kinase	0.0418	0.0168	0.0168
Schistosoma mansoni	protein tyrosine phosphatase	0.032	0.0089	0.0089
Brugia malayi	GCC2 and GCC3 family protein	0.0922	0.0569	0.0569
Echinococcus granulosus	fibroblast growth factor receptor 4	0.037	0.0129	0.0129
Echinococcus granulosus	sphingomyelin synthase protein 1	0.0668	0.0367	0.0367
Schistosoma mansoni	hypothetical protein	0.0668	0.0367	0.0367
Brugia malayi	Fibronectin type III domain containing protein	0.032	0.0089	0.0089
Schistosoma mansoni	tyrosine kinase	0.538	0.4127	0.4127
Schistosoma mansoni	tyrosine kinase	0.3249	0.2427	0.2427
Loa Loa (eye worm)	fibronectin type III domain-containing protein	0.032	0.0089	0.0089
Echinococcus multilocularis	leucine rich repeat serine:threonine protein	0.1229	0.0815	0.0815
Onchocerca volvulus		0.026	0.0042	0.0063
Echinococcus granulosus	Phosphotidylinositol phosphatase PTPRQ	0.032	0.0089	0.0089
Onchocerca volvulus		0.032	0.0089	0.0135
Echinococcus multilocularis	Fibronectin type III domain containing protein	0.032	0.0089	0.0089
Schistosoma mansoni	Protein aveugle	0.0668	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.032	0.0089	0.0089
Echinococcus granulosus	melanoma receptor tyrosine protein kinase	0.538	0.4127	0.4127
Echinococcus multilocularis	Phosphotidylinositol phosphatase PTPRQ	0.032	0.0089	0.0089
Onchocerca volvulus		0.032	0.0089	0.0135
Loa Loa (eye worm)	hypothetical protein	0.032	0.0089	0.0089
Brugia malayi	Furin-like cysteine rich region family protein	0.9908	0.7739	0.7739
Loa Loa (eye worm)	hypothetical protein	0.0922	0.0569	0.0569
Echinococcus granulosus	insulin growth factor 1 receptor beta	0.357	0.2682	0.2682
Loa Loa (eye worm)	hypothetical protein	0.035	0.0113	0.0113
Onchocerca volvulus		0.0415	0.0165	0.0249
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0418	0.0168	0.0168
Schistosoma mansoni	nephrin	0.0528	0.0256	0.0256
Schistosoma mansoni	nephrin	0.0763	0.0443	0.0443
Loa Loa (eye worm)	hypothetical protein	0.032	0.0089	0.0089
Echinococcus granulosus	polyhomeotic proximal chromatin protein	0.0668	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.032	0.0089	0.0089
Echinococcus multilocularis	polycomb protein SCMH1	0.0668	0.0367	0.0367
Echinococcus granulosus	polycomb protein SCMH1	0.0668	0.0367	0.0367
Onchocerca volvulus		0.0668	0.0367	0.0554
Brugia malayi	AIDA-1b	0.0668	0.0367	0.0367
Onchocerca volvulus		0.0922	0.0569	0.086
Loa Loa (eye worm)	hypothetical protein	0.0415	0.0165	0.0165
Brugia malayi	hypothetical protein	0.0668	0.0367	0.0367
Trypanosoma brucei	Fibronectin type III domain containing protein, putative	0.032	0.0089	0.0048
Plasmodium vivax	cysteine repeat modular protein 3, putative	0.0922	0.0569	0.0063
Loa Loa (eye worm)	hypothetical protein	0.0668	0.0367	0.0367
Loa Loa (eye worm)	TK/EGFR protein kinase	0.9908	0.7739	0.7739
Giardia lamblia	CEGP1 protein	0.0922	0.0569	0.021
Loa Loa (eye worm)	hypothetical protein	0.0668	0.0367	0.0367
Schistosoma mansoni	DNAj-like protein	0.0668	0.0367	0.0367
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0434	0.018	0.018
Brugia malayi	Peroxidasin	0.021	0.0001	0.0001
Trichomonas vaginalis	N-myristoyl transferase, putative	0.8372	0.6513	0.638
Brugia malayi	myotactin form B	0.032	0.0089	0.0089
Echinococcus multilocularis	tyrosine protein kinase transmembrane receptor	0.0273	0.0051	0.0051
Schistosoma mansoni	lar interacting protein (lip)-related protein	0.0668	0.0367	0.0367
Onchocerca volvulus		0.032	0.0089	0.0135
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.0528	0.0256	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0556	0.0278	0.0278
Echinococcus multilocularis	insulin receptor	0.3249	0.2427	0.2427
Schistosoma mansoni	factor for adipocyte differentiation	0.032	0.0089	0.0089
Echinococcus multilocularis	liprin alpha 2	0.0668	0.0367	0.0367
Schistosoma mansoni	hypothetical protein	0.0415	0.0165	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0922	0.0569	0.0569
Echinococcus granulosus	twitchin	0.0446	0.019	0.019
Schistosoma mansoni	defective proboscis extension response (dpr)-related	0.0348	0.0112	0.0112
Echinococcus multilocularis	anosmin 1	0.032	0.0089	0.0089
Brugia malayi	ephrin receptor 1 precursor	0.4188	0.3176	0.3176
Onchocerca volvulus		0.032	0.0089	0.0135
Echinococcus multilocularis	contactin neuroglian septate junction protein	0.0528	0.0256	0.0256
Trypanosoma brucei	Present in the outer mitochondrial membrane proteome 24	0.0668	0.0367	0.0327
Brugia malayi	Sphingomyelin synthase-related 1	0.0668	0.0367	0.0367
Schistosoma mansoni	hypothetical protein	0.0668	0.0367	0.0367
Loa Loa (eye worm)	UNCoordinated family member	0.032	0.0089	0.0089
Brugia malayi	Lethal protein 805	0.032	0.0089	0.0089
Onchocerca volvulus		0.032	0.0089	0.0135
Loa Loa (eye worm)	TK protein kinase	0.0465	0.0205	0.0205
Echinococcus multilocularis	liprin alpha 2	0.0668	0.0367	0.0367
Schistosoma mansoni	ephrin receptor	0.0498	0.0231	0.0231
Onchocerca volvulus		0.0415	0.0165	0.0249
Echinococcus multilocularis	histone acetyltransferase myst3	0.0668	0.0367	0.0367
Schistosoma mansoni	hypothetical protein	0.032	0.0089	0.0089
Onchocerca volvulus		0.032	0.0089	0.0135
Trypanosoma cruzi	N-myristoyl transferase, putative	1.2741	1	1
Loa Loa (eye worm)	hypothetical protein	0.0462	0.0202	0.0202
Echinococcus multilocularis	polyhomeotic protein 2	0.0668	0.0367	0.0367
Trypanosoma cruzi	Kinesin-13 5, putative	0.0668	0.0367	0.0327
Brugia malayi	hypothetical protein	0.0668	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.0668	0.0367	0.0367
Echinococcus multilocularis	prolyl 4 hydroxylase subunit alpha 1	0.026	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.0556	0.0278	0.0278
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.032	0.0089	0.0089
Echinococcus granulosus	Fibronectin type III domain containing protein	0.032	0.0089	0.0089
Schistosoma mansoni	receptor protein tyrosine phosphatase	0.032	0.0089	0.0089
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0528	0.0256	0.0256
Loa Loa (eye worm)	hypothetical protein	0.0415	0.0165	0.0165
Loa Loa (eye worm)	hypothetical protein	0.0348	0.0112	0.0112
Echinococcus granulosus	EG95	0.032	0.0089	0.0089
Schistosoma mansoni	titin	0.032	0.0089	0.0089
Loa Loa (eye worm)	hypothetical protein	0.0528	0.0256	0.0256
Schistosoma mansoni	tyrosine kinase	0.538	0.4127	0.4127
Onchocerca volvulus		0.032	0.0089	0.0135
Toxoplasma gondii	kringle domain-containing protein	0.0922	0.0569	0.0963
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.032	0.0089	0.0089
Plasmodium falciparum	glycylpeptide N-tetradecanoyltransferase	1.2741	1	1
Echinococcus multilocularis	roundabout 2	0.0877	0.0533	0.0533
Echinococcus granulosus	receptor type tyrosine protein phosphatase	0.032	0.0089	0.0089
Echinococcus multilocularis	Netrin receptor DCC	0.032	0.0089	0.0089
Echinococcus granulosus	liprin alpha 2	0.0668	0.0367	0.0367
Schistosoma mansoni	spingomyelin synthetase-related	0.0668	0.0367	0.0367
Echinococcus multilocularis	Immunoglobulin	0.0348	0.0112	0.0112
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0415	0.0165	0.0165
Schistosoma mansoni	tyrosine kinase	0.3249	0.2427	0.2427
Trypanosoma cruzi	hypothetical protein, conserved	0.032	0.0089	0.0048
Toxoplasma gondii	hypothetical protein	0.0922	0.0569	0.0963
Loa Loa (eye worm)	hypothetical protein	0.032	0.0089	0.0089
Echinococcus granulosus	receptor type tyrosine protein phosphatase zeta	0.032	0.0089	0.0089
Echinococcus multilocularis	insulin growth factor 1 receptor beta	0.357	0.2682	0.2682
Schistosoma mansoni	tyrosine kinase	0.5202	0.3985	0.3985
Schistosoma mansoni	neuroglian	0.0528	0.0256	0.0256
Schistosoma mansoni	sex comb on midleg homolog	0.0668	0.0367	0.0367
Echinococcus multilocularis	endonuclease reverse transcriptase	0.0922	0.0569	0.0569
Echinococcus granulosus	nephrin	0.0415	0.0165	0.0165
Echinococcus multilocularis	Sterile alpha motif SAM	0.0668	0.0367	0.0367
Schistosoma mansoni	cell adhesion molecule	0.0528	0.0256	0.0256
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0434	0.018	0.018
Trypanosoma cruzi	Kinesin-13 5, putative	0.0668	0.0367	0.0327
Schistosoma mansoni	factor for adipocyte differentiation	0.032	0.0089	0.0089
Schistosoma mansoni	cell adhesion molecule	0.0528	0.0256	0.0256
Schistosoma mansoni	myosin-binding protein-related	0.0415	0.0165	0.0165
Schistosoma mansoni	hypothetical protein	0.0922	0.0569	0.0569
Schistosoma mansoni	polyhomeotic	0.0668	0.0367	0.0367
Echinococcus multilocularis	sphingomyelin synthase protein 1	0.0668	0.0367	0.0367
Loa Loa (eye worm)	immunoglobulin I-set domain-containing protein	0.0415	0.0165	0.0165
Brugia malayi	Protein kinase domain containing protein	0.1229	0.0815	0.0815
Echinococcus granulosus	contactin	0.0528	0.0256	0.0256
Entamoeba histolytica	glycylpeptide N-tetradecanoyltransferase, putative	1.2741	1	1
Giardia lamblia	CDC72	1.2741	1	1
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 30.	0.032	0.0089	0.0089
Loa Loa (eye worm)	hypothetical protein	0.026	0.0042	0.0042
Loa Loa (eye worm)	hypothetical protein	0.032	0.0089	0.0089
Echinococcus granulosus	neuroglian	0.0528	0.0256	0.0256
Onchocerca volvulus		0.032	0.0089	0.0135
Schistosoma mansoni	tyrosine kinase	0.5202	0.3985	0.3985
Echinococcus multilocularis	Receptor type tyrosine protein phosphatase O	0.032	0.0089	0.0089
Echinococcus granulosus	liprin alpha 2	0.0668	0.0367	0.0367
Echinococcus granulosus	insulin receptor	0.3249	0.2427	0.2427
Brugia malayi	Fibronectin type III domain containing protein	0.032	0.0089	0.0089
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0528	0.0256	0.0256
Brugia malayi	sterile alpha and TIR motif containing protein 1 isoform a	0.0668	0.0367	0.0367
Loa Loa (eye worm)	hypothetical protein	0.032	0.0089	0.0089
Brugia malayi	Twik (KCNK-like) family of potassium channels, alpha subunit 32	0.032	0.0089	0.0089
Echinococcus granulosus	titin	0.0418	0.0168	0.0168
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0415	0.0165	0.0165
Schistosoma mansoni	receptor tyrosine phosphatase type r2a	0.0528	0.0256	0.0256

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

ChEMBL: CHEMBL2365089

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1747459