Detailed information for compound 1748495

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 422.427 | Formula: C24H22O7
  • H donors: 0 H acceptors: 1 LogP: 3.37 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)[C@@]12Cc3cc(OC)c(cc3[C@H](O2)c2c(O1)cc(C)oc2=O)OC
  • InChi: 1S/C24H22O7/c1-13-9-20-21(23(25)29-13)22-17-11-19(28-4)18(27-3)10-14(17)12-24(30-20,31-22)15-5-7-16(26-2)8-6-15/h5-11,22H,12H2,1-4H3/t22-,24-/m0/s1
  • InChiKey: GTDDZWFPUABHTD-UPVQGACJSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Escherichia coli penicillin-binding protein Starlite/ChEMBL No references
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL No references
Homo sapiens bromodomain adjacent to zinc finger domain, 2B Starlite/ChEMBL No references
Schistosoma mansoni Thioredoxin glutathione reductase Starlite/ChEMBL No references
Homo sapiens multiple endocrine neoplasia I No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum expressed protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi Bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni bromodomain containing protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Possible penicillin-binding protein Get druggable targets OG5_149948 All targets in OG5_149948
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Cleft lip and palate transmembrane protein 1-like protein, putative Get druggable targets OG5_131570 All targets in OG5_131570
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis bromodomain adjacent to zinc finger domain Get druggable targets OG5_131570 All targets in OG5_131570
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K01549 ATP synthase [EC3.6.3.14], putative Get druggable targets OG5_131570 All targets in OG5_131570
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131570 All targets in OG5_131570
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium knowlesi dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 518 aa 22.0 %
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 521 aa 21.5 %
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast Thioredoxin glutathione reductase   598 aa 513 aa 25.0 %
Neospora caninum glutathione reductase, putative Thioredoxin glutathione reductase   598 aa 532 aa 34.6 %
Neospora caninum hypothetical protein Thioredoxin glutathione reductase   598 aa 485 aa 30.5 %
Plasmodium yoelii dihydrolipoamide dehydrogenase Thioredoxin glutathione reductase   598 aa 537 aa 24.2 %
Toxoplasma gondii NADPH-glutathione reductase Thioredoxin glutathione reductase   598 aa 555 aa 33.5 %
Neospora caninum Dihydrolipoyl dehydrogenase (EC 1.8.1.4), related Thioredoxin glutathione reductase   598 aa 512 aa 28.3 %
Plasmodium berghei dihydrolipoyl dehydrogenase, apicoplast, putative Thioredoxin glutathione reductase   598 aa 538 aa 25.3 %
Onchocerca volvulus Thioredoxin glutathione reductase   598 aa 533 aa 50.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0675 0.5654
Chlamydia trachomatis lysine--tRNA ligase 0.0023 0.0249 1
Loa Loa (eye worm) sugar transporter 0.0029 0.0383 0.0381
Plasmodium falciparum major facilitator superfamily domain-containing protein, putative 0.0029 0.0383 0.0322
Mycobacterium tuberculosis Probable hydrolase 0.0043 0.0675 0.1056
Trichomonas vaginalis conserved hypothetical protein 0.0209 0.4096 1
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0031 0.0425 0.0569
Schistosoma mansoni hypothetical protein 0.0026 0.0324 0.0319
Schistosoma mansoni growth hormone secretagogue receptor 0.0026 0.0324 0.0319
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0026 0.0324 0.0316
Schistosoma mansoni hypothetical protein 0.0047 0.0755 0.075
Mycobacterium ulcerans fusion protein of transposase for IS2606 and sialic acid-transport integral membrane protein NanT 0.0029 0.0383 0.5667
Toxoplasma gondii facilitative glucose transporter GT1 0.0209 0.4096 0.7043
Schistosoma mansoni adenoreceptor 0.0026 0.0324 0.0319
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0324 0.0319
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0104 0.1932 0.8794
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Brugia malayi GnHR receptor homolog 0.0026 0.0324 0.0418
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0026 0.0324 0.0319
Loa Loa (eye worm) PHD-finger family protein 0.0025 0.0291 0.028
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0324 0.0319
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0217 0.0212
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0074 0.1308 0.1304
Echinococcus granulosus sex peptide receptor 0.0026 0.0324 0.0319
Trichomonas vaginalis CAMK family protein kinase 0.0031 0.0425 0.0807
Echinococcus granulosus solute carrier family 22 0.0029 0.0383 0.0378
Plasmodium falciparum calcium-dependent protein kinase 4 0.0031 0.0425 0.0372
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0026 0.0324 0.0319
Trypanosoma cruzi hypothetical protein, conserved 0.0043 0.0675 0.5654
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Schistosoma mansoni bromodomain containing protein 0.0078 0.1398 0.1394
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Schistosoma mansoni ran 0.0021 0.0206 0.0202
Schistosoma mansoni tyrosine kinase 0.0035 0.049 0.0485
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0324 0.0319
Brugia malayi Bromodomain containing protein 0.0046 0.0732 0.0974
Brugia malayi Dopamine receptor 0.0026 0.0324 0.0418
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0035 0.049 0.0485
Echinococcus multilocularis neuropeptide FF receptor 2 0.0026 0.0324 0.0319
Echinococcus granulosus geminin 0.0166 0.3217 0.3214
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0452 0.9131 0.9131
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Brugia malayi hypothetical protein 0.0025 0.0287 0.0369
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0324 0.0319
Echinococcus granulosus tachykinin peptides receptor 99D 0.0026 0.0324 0.0319
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Brugia malayi F/Y-rich N-terminus family protein 0.0013 0.0042 0.0036
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0074 0.1298 0.1294
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0324 0.0319
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0324 0.0319
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Brugia malayi putative neuropeptide receptor NPR1 0.0026 0.0324 0.0418
Echinococcus granulosus 7TM GPCR rhodopsin 0.0026 0.0324 0.0319
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0324 0.0319
Mycobacterium leprae conserved hypothetical protein 0.0043 0.0675 0.2494
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Loa Loa (eye worm) hypothetical protein 0.0028 0.0361 0.0357
Echinococcus granulosus G protein coupled receptor 139 0.0026 0.0324 0.0319
Echinococcus granulosus g-protein coupled receptor 0.0026 0.0324 0.0319
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0324 0.0319
Onchocerca volvulus 0.0029 0.0383 0.086
Trypanosoma brucei glucose transporter, putative 0.0065 0.1115 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0324 0.0319
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0103 0.0118
Echinococcus granulosus solute carrier family 22 0.0029 0.0383 0.0378
Brugia malayi beta-lactamase 0.0043 0.0675 0.0896
Entamoeba histolytica hypothetical protein 0.0023 0.025 0.1547
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1115 0.2535
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0425 0.0421
Echinococcus granulosus metabotropic glutamate receptor 5 0.0452 0.9131 0.9131
Loa Loa (eye worm) glutamate receptor 0.0367 0.7375 0.8069
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0043 0.0675 0.0896
Brugia malayi G-protein coupled receptor 0.0026 0.0324 0.0418
Trichomonas vaginalis importin beta-1, putative 0.0023 0.025 0.0369
Brugia malayi major facilitator superfamily protein 0.0029 0.0383 0.0498
Trypanosoma cruzi extracellular receptor, putative 0.0035 0.049 0.3823
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0425 0.0421
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0733 0.0729
Schistosoma mansoni sugar transporter 0.0029 0.0383 0.0378
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0324 0.0316
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0031 0.0425 0.0372
Toxoplasma gondii prolyl-tRNA synthetase (ProRS) 0.0036 0.0517 0.0731
Giardia lamblia Sugar-proton symporter 0.0029 0.0383 0.9051
Schistosoma mansoni hypothetical protein 0.0026 0.0324 0.0319
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0026 0.0324 0.0319
Giardia lamblia Hexose transporter 0.0029 0.0383 0.9051
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.0094 0.1723 0.1855
Brugia malayi hypothetical protein 0.0026 0.0324 0.0418
Echinococcus multilocularis beta LACTamase domain containing family member 0.0043 0.0675 0.0671
Echinococcus multilocularis G-protein coupled receptor, putative 0.0026 0.0324 0.0319
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0035 0.049 0.0485
Echinococcus multilocularis geminin 0.0166 0.3217 0.3214
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0324 0.0319
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0675 0.1433
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.0037 0.0531 0.0527
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0043 0.0675 0.1056
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0043 0.0673 0.0669
Trypanosoma brucei myo-inositol/proton symporter (MIT) 0.0029 0.0383 0.2764
Brugia malayi hypothetical protein 0.0026 0.0324 0.0418
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0021 0.0217 0.0212
Loa Loa (eye worm) RGC/RGC protein kinase 0.0035 0.049 0.0498
Onchocerca volvulus 0.0029 0.0383 0.086
Loa Loa (eye worm) hypothetical protein 0.0025 0.0287 0.0275
Echinococcus granulosus solute carrier family 22 0.0029 0.0383 0.0378
Plasmodium falciparum importin beta, putative 0.0028 0.0361 0.0297
Loa Loa (eye worm) hypothetical protein 0.0046 0.0734 0.0767
Plasmodium falciparum calcium-dependent protein kinase 2 0.0031 0.0425 0.0372
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0324 0.0319
Brugia malayi RE15519p 0.0026 0.0324 0.0418
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0675 0.1433
Mycobacterium tuberculosis Probable lipase LipD 0.0043 0.0675 0.1056
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0324 0.0319
Loa Loa (eye worm) hypothetical protein 0.0035 0.049 0.0498
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0324 0.0319
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0324 0.0319
Echinococcus granulosus synaptic vesicle 2 protein 0.0029 0.0383 0.0378
Schistosoma mansoni sugar transporter 0.0029 0.0383 0.0378
Toxoplasma gondii sugar transporter ST3 0.0029 0.0383 0.0494
Brugia malayi metabotropic GABA-B receptor subtype 2 0.0035 0.049 0.0644
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0095 0.0091
Trypanosoma brucei glucose transporter, putative 0.0065 0.1115 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0206 0.0202
Schistosoma mansoni hypothetical protein 0.0025 0.0291 0.0286
Echinococcus granulosus alpha 1A adrenergic receptor 0.0026 0.0324 0.0319
Loa Loa (eye worm) hypothetical protein 0.0023 0.0249 0.0234
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.1115 1
Brugia malayi G-protein coupled receptor 0.0026 0.0324 0.0418
Echinococcus multilocularis GPCR, family 2 0.0015 0.0095 0.0091
Plasmodium vivax calcium-dependent protein kinase, putative 0.0031 0.0425 0.0372
Brugia malayi putative neuropeptide receptor 0.0026 0.0324 0.0418
Mycobacterium tuberculosis Conserved protein 0.0043 0.0675 0.1056
Echinococcus granulosus histone lysine methyltransferase setb 0.0021 0.0217 0.0212
Toxoplasma gondii histone lysine methyltransferase SET1 0.0069 0.1194 0.1925
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0249 0.0244
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.025 0.0369
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0425 0.0421
Onchocerca volvulus 0.0029 0.0383 0.086
Schistosoma mansoni hypothetical protein 0.0302 0.6027 0.6025
Brugia malayi hypothetical protein 0.0026 0.0324 0.0418
Mycobacterium tuberculosis Conserved protein 0.0043 0.0675 0.1056
Onchocerca volvulus 0.0035 0.0493 0.2472
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0324 0.0319
Echinococcus granulosus methyl CpG binding domain protein 2 0.0021 0.0201 0.0197
Brugia malayi Receptor family ligand binding region containing protein 0.0035 0.049 0.0644
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Echinococcus multilocularis nmda type glutamate receptor 0.0035 0.049 0.0485
Trypanosoma cruzi glucose transporter, putative 0.0029 0.0383 0.2764
Loa Loa (eye worm) hypothetical protein 0.0043 0.0675 0.0702
Onchocerca volvulus 0.0029 0.0383 0.086
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.025 0.0369
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Mycobacterium leprae Probable lipase LipE 0.0043 0.0675 0.2494
Plasmodium vivax importin-beta 2, putative 0.0028 0.0361 0.0297
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0324 0.0319
Trypanosoma brucei sugar transporter, putative 0.0029 0.0383 0.2764
Loa Loa (eye worm) RGC/RGC protein kinase 0.0035 0.049 0.0498
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0026 0.0324 0.0319
Entamoeba histolytica protein kinase, putative 0.0031 0.0425 0.7721
Loa Loa (eye worm) hypothetical protein 0.0035 0.049 0.0498
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Schistosoma mansoni neuropeptide F-like receptor 0.0026 0.0324 0.0319
Schistosoma mansoni amine GPCR 0.0026 0.0324 0.0319
Schistosoma mansoni hypothetical protein 0.0015 0.0095 0.0091
Brugia malayi ORL1-like opioid receptor 0.0026 0.0324 0.0418
Plasmodium vivax glutathione reductase, putative 0.0046 0.0721 0.0712
Schistosoma mansoni metabotropic glutamate receptor 0.0308 0.6142 0.614
Mycobacterium ulcerans sugar transporter 0.0029 0.0383 0.5667
Echinococcus granulosus tyrosine kinase 0.0035 0.049 0.0485
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0412 0.0407
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Echinococcus multilocularis dnaJ subfamily B 0.0494 1 1
Treponema pallidum NADH oxidase 0.0016 0.0103 1
Mycobacterium ulcerans beta-lactamase 0.0043 0.0675 1
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0029 0.038 0.0375
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0026 0.0324 0.0418
Brugia malayi hypothetical protein 0.0232 0.4578 0.6199
Trypanosoma brucei bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0517 0.4096
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1115 0.2535
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0029 0.038 0.0375
Echinococcus multilocularis neuropeptide receptor A26 0.0026 0.0324 0.0319
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Schistosoma mansoni hypothetical protein 0.0026 0.0324 0.0319
Schistosoma mansoni sugar transporter 0.0029 0.0383 0.0378
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Echinococcus granulosus beta LACTamase domain containing family member 0.0043 0.0675 0.0671
Echinococcus multilocularis g protein coupled receptor 0.0026 0.0324 0.0319
Entamoeba histolytica hypothetical protein 0.0035 0.049 1
Mycobacterium tuberculosis Probable dicarboxylic acid transport integral membrane protein KgtP (dicarboxylate transporter) 0.0029 0.0383 0.0516
Plasmodium falciparum calcium-dependent protein kinase 3 0.0031 0.0425 0.0372
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0103 0.0098
Echinococcus multilocularis sex peptide receptor 0.0026 0.0324 0.0319
Trypanosoma brucei glucose transporter, putative 0.0065 0.1115 1
Leishmania major glucose transporter, lmgt1 0.0065 0.1115 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0324 0.0319
Schistosoma mansoni myosin xvIII 0.0026 0.0324 0.0319
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0324 0.0319
Onchocerca volvulus Poor gastrulation protein homolog 0.006 0.1009 1
Schistosoma mansoni hypothetical protein 0.0033 0.0467 0.0463
Trichomonas vaginalis sugar transporter, putative 0.0065 0.1115 0.2535
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0324 0.0319
Schistosoma mansoni opsin-like receptor 0.0026 0.0324 0.0319
Mycobacterium leprae Probable prolyl tRNA synthetase ProS 0.0031 0.0412 0.1175
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0043 0.0675 1
Echinococcus multilocularis solute carrier family 22 0.0029 0.0383 0.0378
Loa Loa (eye worm) hypothetical protein 0.0029 0.0383 0.0381
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Brugia malayi sulfakinin receptor protein 0.0026 0.0324 0.0418
Leishmania major myo-inositol/proton symporter (MIT) 0.0029 0.0383 0.2764
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.025 0.1454
Onchocerca volvulus 0.0047 0.0755 0.6293
Loa Loa (eye worm) hypothetical protein 0.006 0.1009 0.1069
Brugia malayi neuropeptide F receptor 0.0026 0.0324 0.0418
Brugia malayi bifunctional aminoacyl-tRNA synthetase 0.0031 0.0412 0.0538
Loa Loa (eye worm) hypothetical protein 0.0232 0.4578 0.4993
Toxoplasma gondii protein kinase, putative 0.029 0.5772 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0026 0.0324 0.0319
Loa Loa (eye worm) hypothetical protein 0.0029 0.0383 0.0381
Echinococcus granulosus nmda type glutamate receptor 0.0035 0.049 0.0485
Brugia malayi Sugar transporter family protein 0.0029 0.0383 0.0498
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0324 0.0319
Trypanosoma cruzi hexose transporter, putative 0.0065 0.1115 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0104 0.1932 0.3374
Echinococcus multilocularis orexin receptor type 2 0.0026 0.0324 0.0319
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Brugia malayi Sugar transporter family protein 0.0029 0.0383 0.0498
Mycobacterium tuberculosis Probable lipase LipE 0.0043 0.0675 0.1056
Echinococcus granulosus snurportin 1 0.0302 0.6027 0.6025
Loa Loa (eye worm) hypothetical protein 0.0049 0.0793 0.0832
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0035 0.049 0.0485
Brugia malayi Dopamine receptor protein 2 0.0026 0.0324 0.0418
Echinococcus multilocularis solute carrier family 22 0.0029 0.0383 0.0378
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0026 0.0324 0.0319
Loa Loa (eye worm) beta-lactamase 0.0043 0.0675 0.0702
Echinococcus granulosus neuropeptide receptor 0.0026 0.0324 0.0319
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0031 0.0425 0.0556
Echinococcus granulosus serotonin receptor 0.0026 0.0324 0.0319
Trichomonas vaginalis myo-inositol transporter, putative 0.0029 0.0383 0.0701
Schistosoma mansoni biogenic amine receptor 0.0026 0.0324 0.0319
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0308 0.6142 0.614
Loa Loa (eye worm) hypothetical protein 0.0094 0.1723 0.1855
Onchocerca volvulus 0.0029 0.0383 0.086
Brugia malayi major facilitator superfamily protein 0.0029 0.0383 0.0498
Echinococcus multilocularis dro:myosuppressin receptor 0.0026 0.0324 0.0319
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0517 0.4096
Trichomonas vaginalis glucose transporter, putative 0.0029 0.0383 0.0701
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Plasmodium falciparum protein kinase 7 0.029 0.5772 0.6531
Brugia malayi Metabotropic glutamate receptor precursor. 0.0367 0.7375 1
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.4096 0.4093
Loa Loa (eye worm) hypothetical protein 0.0029 0.0383 0.0381
Mycobacterium tuberculosis Probable reductase 0.0104 0.1932 0.3374
Loa Loa (eye worm) hypothetical protein 0.0029 0.0383 0.0381
Loa Loa (eye worm) hypothetical protein 0.0031 0.0412 0.0413
Loa Loa (eye worm) CXXC zinc finger family protein 0.0035 0.0493 0.0502
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0287 0.1821
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Echinococcus multilocularis solute carrier family 2, facilitated glucose 0.0209 0.4096 0.4093
Schistosoma mansoni neuropeptide receptor 0.0026 0.0324 0.0319
Echinococcus multilocularis g-protein coupled receptor 0.0026 0.0324 0.0319
Onchocerca volvulus 0.0029 0.0383 0.086
Mycobacterium tuberculosis Probable esterase LipL 0.0043 0.0675 0.1056
Trichomonas vaginalis prolyl-tRNA synthetase, putative 0.0031 0.0412 0.0774
Echinococcus granulosus neuropeptide Y receptor 0.0026 0.0324 0.0319
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Echinococcus granulosus metabotropic glutamate receptor 2 0.0308 0.6142 0.614
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0026 0.0324 0.0319
Schistosoma mansoni ran 0.0021 0.0206 0.0202
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Loa Loa (eye worm) bromodomain containing protein 0.0021 0.0217 0.0198
Echinococcus multilocularis receptor type guanylyl cyclase 0.0035 0.049 0.0485
Schistosoma mansoni sugar transporter 0.0029 0.0383 0.0378
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0026 0.0324 0.0319
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0026 0.0324 0.0319
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0206 0.0259
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0026 0.0324 0.0319
Leishmania major lysyl-tRNA synthetase, putative 0.0023 0.0249 0.1443
Trypanosoma brucei glucose transporter 1E 0.0065 0.1115 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0287 0.1821
Loa Loa (eye worm) hypothetical protein 0.0035 0.049 0.0498
Loa Loa (eye worm) hypothetical protein 0.0043 0.0675 0.0702
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0675 0.0671
Schistosoma mansoni glutamate receptor NMDA 0.0035 0.049 0.0485
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0043 0.0675 0.0671
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0383 0.0498
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.0361 0.0455
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0031 0.0425 0.0427
Leishmania major glucose transporter, lmgt3 0.0065 0.1115 1
Brugia malayi lysyl-tRNA synthetase 0.0023 0.0249 0.0317
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0103 0.0098
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0026 0.0324 0.0319
Leishmania major hypothetical protein, conserved 0.0029 0.0383 0.2764
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0324 0.0319
Echinococcus multilocularis solute carrier family 22 0.0029 0.0383 0.0378
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Brugia malayi Serotonin receptor 0.0026 0.0324 0.0418
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Brugia malayi Serotonin receptor 0.0026 0.0324 0.0418
Echinococcus granulosus General substrate transporter 0.0179 0.3488 0.3485
Loa Loa (eye worm) hypothetical protein 0.0029 0.0383 0.0381
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0383 0.0498
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0206 0.1021
Leishmania major glucose transporter/membrane transporter D2, putative 0.0065 0.1115 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0095 0.0091
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0733 0.0729
Toxoplasma gondii sugar transporter ST2 0.0029 0.0383 0.0494
Leishmania major trypanothione reductase 0.0046 0.0721 0.6105
Schistosoma mansoni survival motor neuron protein 0.0047 0.0755 0.075
Trypanosoma cruzi sugar transporter, putative 0.0029 0.0383 0.2764
Onchocerca volvulus 0.0029 0.0383 0.086
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0026 0.0324 0.0418
Brugia malayi hypothetical protein 0.0029 0.0383 0.0498
Brugia malayi hypothetical protein 0.0026 0.0324 0.0418
Loa Loa (eye worm) hypothetical protein 0.0029 0.0383 0.0381
Schistosoma mansoni glucose transporter 0.0029 0.0383 0.0378
Brugia malayi Dopamine receptor protein 1 0.0026 0.0324 0.0418
Trypanosoma cruzi hexose transporter, putative 0.0065 0.1115 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0287 0.0212
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0675 0.1433
Onchocerca volvulus Metabotropic glutamate receptor homolog 0.006 0.1009 1
Schistosoma mansoni hypothetical protein 0.0166 0.3217 0.3214
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0206 0.0187
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0031 0.0425 0.0372
Loa Loa (eye worm) hypothetical protein 0.0053 0.0882 0.093
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0043 0.0673 0.0669
Schistosoma mansoni biogenic amine receptor 0.0026 0.0324 0.0319
Brugia malayi Sugar transporter family protein 0.0209 0.4096 0.5544
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0721 0.0752
Loa Loa (eye worm) hypothetical protein 0.0043 0.0675 0.0702
Leishmania major GTP-binding protein, putative 0.0021 0.0206 0.1021
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Loa Loa (eye worm) hypothetical protein 0.0035 0.049 0.0498
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0467 0.0613
Echinococcus multilocularis serotonin receptor 0.0026 0.0324 0.0319
Trypanosoma brucei trypanothione reductase 0.0046 0.0721 0.6105
Onchocerca volvulus 0.0035 0.049 0.2424
Plasmodium falciparum calcium-dependent protein kinase 1 0.0031 0.0425 0.0372
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0425 0.0421
Brugia malayi hypothetical protein 0.0035 0.049 0.0644
Echinococcus multilocularis Sugar transporter ERD6 protein 0.0029 0.0383 0.0378
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0026 0.0324 0.0319
Brugia malayi larval opioid receptor 0.0026 0.0324 0.0418
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0324 0.0319
Brugia malayi hypothetical protein 0.0026 0.0324 0.0418
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0206 0.0182
Echinococcus multilocularis tyrosine kinase 0.0035 0.049 0.0485
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0425 0.0421
Schistosoma mansoni neuropeptide receptor 0.0026 0.0324 0.0319
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0324 0.0319
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0031 0.0425 0.0569
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Schistosoma mansoni protein kinase 0.0031 0.0425 0.0421
Loa Loa (eye worm) hypothetical protein 0.0029 0.0383 0.0381
Plasmodium vivax proline--tRNA ligase, putative 0.0036 0.0517 0.0478
Mycobacterium tuberculosis Probable dehydrogenase 0.0104 0.1932 0.3374
Schistosoma mansoni zinc finger protein 0.0018 0.0157 0.0153
Onchocerca volvulus 0.0029 0.0383 0.086
Schistosoma mansoni opsin-like receptor 0.0026 0.0324 0.0319
Brugia malayi hypothetical protein 0.0029 0.0383 0.0498
Schistosoma mansoni glutamyl-tRNA synthetase cytoplasmic (glutamate--tRNA ligase) (glurs) 0.0031 0.0412 0.0407
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Echinococcus granulosus peptide allatostatin:somatostatin 0.0026 0.0324 0.0319
Leishmania major prolyl-tRNA synthetase, putative,bifunctional aminoacyl-tRNA synthetase, putative 0.0036 0.0517 0.4096
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0755 0.1004
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0324 0.0319
Leishmania major hypothetical protein, conserved 0.0018 0.0157 0.0541
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0095 0.0091
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0026 0.0324 0.0319
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0095 0.0091
Onchocerca volvulus 0.0035 0.049 0.2424
Schistosoma mansoni serine/threonine protein kinase 0.0031 0.0425 0.0421
Echinococcus multilocularis zinc finger protein 0.0026 0.0305 0.0301
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0103 0.0098
Schistosoma mansoni nuclear transcription factor X-box binding 1 (nfx1) 0.0029 0.0383 0.0378
Brugia malayi Tachykinin-like peptides receptor 99D 0.0026 0.0324 0.0418
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0206 0.0119
Trypanosoma brucei glucose transporter, putative 0.0065 0.1115 1
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Brugia malayi glutathione reductase 0.0046 0.0721 0.0958
Brugia malayi hypothetical protein 0.0016 0.0106 0.0122
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Entamoeba histolytica hypothetical protein 0.0023 0.0249 0.1508
Plasmodium falciparum thioredoxin reductase 0.0046 0.0721 0.0712
Loa Loa (eye worm) hypothetical protein 0.0031 0.0412 0.0413
Loa Loa (eye worm) TYRA-2 protein 0.0026 0.0324 0.0316
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0324 0.0319
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.4096 0.4093
Onchocerca volvulus 0.0043 0.0675 0.5131
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0302 0.6027 0.6587
Leishmania major protein kinase, putative 0.0031 0.0425 0.3184
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0324 0.0319
Schistosoma mansoni neuropeptide receptor 0.0026 0.0324 0.0319
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0026 0.0324 0.0319
Schistosoma mansoni neuropeptide f receptor 76f 0.0026 0.0324 0.0319
Schistosoma mansoni cpg binding protein 0.0035 0.0493 0.0489
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0026 0.0324 0.0319
Loa Loa (eye worm) hypothetical protein 0.0029 0.0383 0.0381
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0026 0.0324 0.0319
Brugia malayi AKH receptor 0.0026 0.0324 0.0418
Trypanosoma brucei glucose transporter, putative 0.0065 0.1115 1
Schistosoma mansoni glucose transport protein 0.0209 0.4096 0.4093
Onchocerca volvulus 0.0029 0.0383 0.086
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0206 0.0119
Echinococcus granulosus 7tm_1 domain containing protein 0.0026 0.0324 0.0319
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0026 0.0324 0.0418
Echinococcus granulosus hypothetical protein 0.0026 0.0324 0.0319
Loa Loa (eye worm) hypothetical protein 0.0025 0.0292 0.0281
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0324 0.0316
Echinococcus granulosus solute carrier family 22 0.0029 0.0383 0.0378
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Echinococcus multilocularis lysyl tRNA synthetase 0.0023 0.0249 0.0244
Echinococcus granulosus biogenic amine 5HT receptor 0.0026 0.0324 0.0319
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0324 0.0319
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0026 0.0324 0.0418
Schistosoma mansoni amine GPCR 0.0026 0.0324 0.0319
Mycobacterium ulcerans hypothetical protein 0.0043 0.0675 1
Giardia lamblia Prolyl-tRNA synthetase 0.0031 0.0412 1
Giardia lamblia Lysyl-tRNA synthetase 0.0023 0.0249 0.4726
Schistosoma mansoni cpg binding protein 0.0039 0.0582 0.0577
Leishmania major extracellular receptor, putative 0.0035 0.049 0.3823
Echinococcus granulosus neuropeptide s receptor 0.0026 0.0324 0.0319
Brugia malayi hypothetical protein 0.0029 0.0383 0.0498
Schistosoma mansoni hypothetical protein 0.0026 0.0324 0.0319
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0026 0.0324 0.0319
Plasmodium falciparum hexose transporter 0.0209 0.4096 0.4599
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0361 0.2549
Trypanosoma cruzi lysyl-tRNA synthetase, putative 0.0023 0.0249 0.1443
Echinococcus granulosus zinc finger protein 0.0026 0.0305 0.0301
Loa Loa (eye worm) hypothetical protein 0.0452 0.9131 1
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0031 0.0425 0.0427
Schistosoma mansoni hypothetical protein 0.0018 0.0157 0.0153
Mycobacterium tuberculosis Lysyl-tRNA synthetase 1 LysS (lysine--tRNA ligase 1) (LysRS 1) (lysine translase) 0.0019 0.0177 0.0138
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Loa Loa (eye worm) hypothetical protein 0.0085 0.1543 0.1656
Loa Loa (eye worm) sugar transporter 0.0209 0.4096 0.4463
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0026 0.0324 0.0319
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0043 0.0675 0.0702
Plasmodium vivax hexose transporter 0.0209 0.4096 0.4599
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0324 0.0319
Loa Loa (eye worm) hypothetical protein 0.0043 0.0675 0.0702
Loa Loa (eye worm) hypothetical protein 0.0029 0.0383 0.0381
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Mycobacterium ulcerans sugar-transport integral membrane protein SugI 0.0029 0.0383 0.5667
Brugia malayi Thioredoxin reductase 0.0046 0.0721 0.0958
Schistosoma mansoni amine GPCR 0.0026 0.0324 0.0319
Leishmania major importin beta-1 subunit, putative 0.0023 0.025 0.1454
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0026 0.0324 0.0319
Onchocerca volvulus 0.0043 0.0675 0.5131
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0324 0.0319
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0324 0.0319
Schistosoma mansoni hypothetical protein 0.0015 0.0095 0.0091
Brugia malayi Guanylyl cyclase protein 23 0.0035 0.049 0.0644
Onchocerca volvulus 0.0029 0.0383 0.086
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0278 0.5525 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0206 0.1021
Brugia malayi beta-lactamase family protein 0.0043 0.0675 0.0896
Plasmodium falciparum calcium-dependent protein kinase 5 0.0031 0.0425 0.0372
Brugia malayi Major Facilitator Superfamily protein 0.0029 0.0383 0.0498
Echinococcus granulosus GPCR family 3 C terminal 0.006 0.1009 0.1004
Brugia malayi hypothetical protein 0.0026 0.0324 0.0418
Trypanosoma brucei glucose transporter 2A 0.0065 0.1115 1
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0201 0.0197
Echinococcus multilocularis allatostatin A receptor 0.0026 0.0324 0.0319
Loa Loa (eye worm) hypothetical protein 0.0029 0.0383 0.0381
Toxoplasma gondii thioredoxin reductase 0.0046 0.0721 0.109
Onchocerca volvulus Putative transporter 0.0029 0.0383 0.086
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0324 0.0319
Echinococcus granulosus sodium channel protein 0.0037 0.0531 0.0527
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Plasmodium falciparum mitogen-activated protein kinase 2 0.0166 0.3205 0.3574
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0031 0.0425 0.0372
Echinococcus granulosus dro:myosuppressin receptor 0.0026 0.0324 0.0319
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0016 0.0103 0.1522
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0324 0.0319
Schistosoma mansoni protein kinase 0.0031 0.0425 0.0421
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0249 0.3686
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0116 0.2173 0.3818
Echinococcus granulosus Sugar transporter ERD6 protein 0.0029 0.0383 0.0378
Leishmania major calcium channel protein, putative,ion transporter, putative 0.0037 0.0531 0.4234
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0788 0.1049
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0383 0.0701
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0324 0.0319
Echinococcus granulosus receptor type guanylyl cyclase 0.0035 0.049 0.0485
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.1115 1
Echinococcus multilocularis importin subunit beta 1 0.0028 0.0361 0.0356
Echinococcus multilocularis cpg binding protein 0.0039 0.0582 0.0577
Trypanosoma brucei glucose transporter, putative 0.0065 0.1115 1
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0206 0.3343
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0031 0.0425 0.0421
Schistosoma mansoni amine GPCR 0.0026 0.0324 0.0319
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0209 0.4096 0.4093
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0206 0.0202
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0721 0.6105
Schistosoma mansoni hypothetical protein 0.0209 0.4096 0.4093
Loa Loa (eye worm) melatonin receptor type 1A 0.0026 0.0324 0.0316
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Schistosoma mansoni alpha-1 adrenergic receptor 0.0026 0.0324 0.0319
Schistosoma mansoni zinc finger protein 0.0026 0.0305 0.0301
Trypanosoma brucei glucose transporter, putative 0.0065 0.1115 1
Echinococcus multilocularis GPCR, family 3, C terminal 0.006 0.1009 0.1004
Mycobacterium ulcerans integral membrane transport protein 0.0029 0.0383 0.5667
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Schistosoma mansoni biogenic amine (5HT) receptor 0.0026 0.0324 0.0319
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Brugia malayi Cam kinase protein 1 0.0031 0.0425 0.0556
Loa Loa (eye worm) hypothetical protein 0.0015 0.0095 0.0065
Leishmania major hypothetical protein, conserved 0.0043 0.0675 0.5654
Echinococcus granulosus atrial natriuretic peptide receptor 0.0035 0.049 0.0485
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0116 0.2173 1
Echinococcus multilocularis solute carrier family 22 0.0029 0.0383 0.0378
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0324 0.0319
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Schistosoma mansoni hypothetical protein 0.0015 0.0095 0.0091
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.1115 0.2535
Brugia malayi Melatonin receptor type 1A 0.0026 0.0324 0.0418
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0095 0.0108
Trypanosoma brucei glucose transporter, putative 0.0065 0.1115 1
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0287 0.1821
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0026 0.0324 0.0319
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Onchocerca volvulus 0.0029 0.0383 0.086
Echinococcus granulosus fetal alzheimer antigen falz 0.0029 0.038 0.0375
Schistosoma mansoni methyl-cpg binding protein mbd 0.0021 0.0201 0.0197
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0517 0.4096
Loa Loa (eye worm) hypothetical protein 0.0043 0.0675 0.0702
Brugia malayi G protein-coupled receptor F59B2.13 0.0026 0.0324 0.0418
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0287 0.0325
Schistosoma mansoni tyrosine kinase 0.0035 0.049 0.0485
Plasmodium falciparum protein kinase 6 0.0435 0.8784 1
Echinococcus multilocularis serotonin receptor 0.0026 0.0324 0.0319
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0383 0.0701
Echinococcus multilocularis neuropeptide Y receptor 0.0026 0.0324 0.0319
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0333 0.6661 0.9029
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Echinococcus granulosus orexin receptor type 2 0.0026 0.0324 0.0319
Brugia malayi Bifunctional aminoacyl-tRNA synthetase 0.0031 0.0412 0.0538
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0035 0.049 0.0485
Echinococcus granulosus neuropeptide receptor 0.0026 0.0324 0.0319
Plasmodium vivax lysine--tRNA ligase, putative 0.0023 0.0249 0.0168
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Echinococcus granulosus neuropeptide FF receptor 2 0.0026 0.0324 0.0319
Schistosoma mansoni amine GPCR 0.0026 0.0324 0.0319
Brugia malayi hypothetical protein 0.0026 0.0324 0.0418
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0324 0.0319
Leishmania major glucose transporter, lmgt2 0.0065 0.1115 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0206 0.1021
Loa Loa (eye worm) hypothetical protein 0.0021 0.0217 0.0199
Echinococcus granulosus glutamate receptor 2 0.0035 0.049 0.0485
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Schistosoma mansoni protein kinase 0.0035 0.049 0.0485
Echinococcus multilocularis glutamate receptor 2 0.0035 0.049 0.0485
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.4096 0.4093
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Echinococcus granulosus g protein coupled receptor 0.0026 0.0324 0.0319
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0116 0.2173 0.3818
Loa Loa (eye worm) hypothetical protein 0.0029 0.0383 0.0381
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0324 0.0319
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.1115 0.2535
Schistosoma mansoni neuropeptide receptor 0.0026 0.0324 0.0319
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.4578 0.4575
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.0094 0.1723 0.1855
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.0035 0.049 0.2424
Wolbachia endosymbiont of Brugia malayi major facilitator superfamily permease 0.0029 0.0383 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0043 0.0675 0.1056
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0383 0.0701
Schistosoma mansoni glucose transport protein 0.0209 0.4096 0.4093
Loa Loa (eye worm) hypothetical protein 0.0029 0.0383 0.0381
Loa Loa (eye worm) hypothetical protein 0.0029 0.0383 0.0381
Echinococcus granulosus solute carrier family 2 facilitated glucose 0.0209 0.4096 0.4093
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0104 0.1932 0.3374
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0324 0.0319
Brugia malayi Importin beta-1 subunit 0.0028 0.0361 0.0469
Loa Loa (eye worm) hypothetical protein 0.0049 0.0788 0.0826
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0324 0.0319
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0095 0.0108
Echinococcus granulosus somatostatin receptor 0.0026 0.0324 0.0319
Schistosoma mansoni opsin-like receptor 0.0026 0.0324 0.0319
Trypanosoma brucei THT1 - hexose transporter, putative 0.0065 0.1115 1
Trypanosoma cruzi hexose transporter, putative 0.0065 0.1115 1
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0383 0.0701
Mycobacterium leprae Possible lysyl-tRNA synthetase 2 LysX 0.0023 0.0249 0.0358
Echinococcus granulosus neuropeptide receptor A26 0.0026 0.0324 0.0319
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Plasmodium falciparum lysine--tRNA ligase 0.0023 0.0249 0.0168
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0026 0.0324 0.0319
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Echinococcus multilocularis General substrate transporter 0.0179 0.3488 0.3485
Echinococcus granulosus neuropeptides capa receptor 0.0026 0.0324 0.0319
Plasmodium vivax CDK-related protein kinase 6, putative 0.0435 0.8784 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0026 0.0324 0.0316
Trypanosoma cruzi ISWI complex protein 0.0018 0.0157 0.0541
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0035 0.049 0.0485
Brugia malayi follicle stimulating hormone receptor 0.0026 0.0324 0.0418
Echinococcus granulosus fmrfamide receptor 0.0026 0.0324 0.0319
Echinococcus multilocularis synaptic vesicle 2 protein 0.0029 0.0383 0.0378
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0035 0.049 0.0485
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0324 0.0319
Mycobacterium tuberculosis Conserved protein 0.0043 0.0675 0.1056
Entamoeba histolytica prolyl-tRNA synthetase, putative 0.0031 0.0412 0.7257
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0016 0.0103 0.1522
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0788 0.0826
Trichomonas vaginalis esterase, putative 0.0043 0.0675 0.1433
Toxoplasma gondii cell-cycle-associated protein kinase MAPK, putative 0.0166 0.3205 0.5472
Onchocerca volvulus 0.0029 0.0383 0.086
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0026 0.0324 0.0319
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0031 0.0425 0.0569
Schistosoma mansoni histamine h1 receptor 0.0026 0.0324 0.0319
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0383 0.0381
Loa Loa (eye worm) hypothetical protein 0.0029 0.0383 0.0381
Plasmodium vivax hypothetical protein, conserved 0.0043 0.0675 0.0659
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0103 0.4129
Toxoplasma gondii transporter, major facilitator family protein 0.0029 0.0383 0.0494
Echinococcus granulosus cpg binding protein 0.0039 0.0582 0.0577
Brugia malayi Receptor family ligand binding region containing protein 0.0094 0.1723 0.232
Loa Loa (eye worm) RGC/RGC protein kinase 0.0035 0.049 0.0498
Plasmodium falciparum glutathione reductase 0.0046 0.0721 0.0712
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Echinococcus multilocularis G protein coupled receptor 139 0.0026 0.0324 0.0319
Plasmodium vivax sugar transporter, putative 0.0029 0.0383 0.0322
Echinococcus multilocularis neuropeptide receptor 0.0026 0.0324 0.0319
Brugia malayi hypothetical protein 0.0026 0.0324 0.0418
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.0023 0.0249 0.0366
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0287 0.0212
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.0035 0.049 0.0498
Loa Loa (eye worm) hypothetical protein 0.0043 0.0675 0.0702
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Loa Loa (eye worm) hypothetical protein 0.0035 0.049 0.0498
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0074 0.1308 0.1304
Schistosoma mansoni biogenic amine receptor 0.0026 0.0324 0.0319
Toxoplasma gondii sugar transporter ST1 0.0029 0.0383 0.0494
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.0361 0.2549
Brugia malayi RNA, U transporter 1 0.008 0.1441 0.1936
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Brugia malayi metabotropic glutamate receptor type 2 0.0179 0.3479 0.4707
Loa Loa (eye worm) glutamate receptor 0.0144 0.2765 0.3
Schistosoma mansoni metabotropic glutamate receptor 0.0179 0.3479 0.3476
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0417 0.8417 0.8416
Schistosoma mansoni hypothetical protein 0.0494 1 1
Echinococcus granulosus lysyl tRNA synthetase 0.0023 0.0249 0.0244
Trypanosoma cruzi prolyl-tRNA synthetase, putative 0.0036 0.0517 0.4096
Onchocerca volvulus 0.0029 0.0383 0.086
Echinococcus granulosus GPCR family 2 0.0015 0.0095 0.0091
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0021 0.0217 0.0212
Schistosoma mansoni glucose transport protein 0.0209 0.4096 0.4093
Brugia malayi PHD-finger family protein 0.0032 0.0439 0.0575
Schistosoma mansoni cpg binding protein 0.0039 0.0582 0.0577
Loa Loa (eye worm) hypothetical protein 0.0029 0.0383 0.0381
Entamoeba histolytica protein kinase, putative 0.0031 0.0425 0.7721
Schistosoma mansoni lysyl-tRNA synthetase 0.0023 0.0249 0.0244
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Loa Loa (eye worm) glutathione reductase 0.0046 0.0721 0.0752
Echinococcus granulosus calcium dependent protein kinase 0.0029 0.0385 0.038
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0324 0.0319
Echinococcus multilocularis neuropeptide s receptor 0.0026 0.0324 0.0319
Brugia malayi metabotropic GABA-B receptor subtype 2 0.006 0.1009 0.1349
Trypanosoma brucei lysyl-tRNA synthetase, putative 0.0023 0.0249 0.1443
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0104 0.1932 0.3374
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Brugia malayi G protein-coupled receptor 0.0026 0.0324 0.0418
Echinococcus granulosus g protein coupled receptor 0.0026 0.0324 0.0319
Loa Loa (eye worm) hypothetical protein 0.0031 0.0425 0.0427
Onchocerca volvulus 0.0029 0.0383 0.086
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0026 0.0324 0.0319
Trichomonas vaginalis glucose transporter, putative 0.0065 0.1115 0.2535
Echinococcus multilocularis snurportin 1 0.0302 0.6027 0.6025
Onchocerca volvulus 0.0043 0.0675 0.5131
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0287 0.0212
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0026 0.0324 0.0418
Plasmodium falciparum proline--tRNA ligase 0.0036 0.0517 0.0478
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0021 0.0201 0.0197
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0031 0.0425 0.0421
Trypanosoma cruzi hexose transporter 0.0065 0.1115 1
Echinococcus multilocularis sodium channel protein 0.0037 0.0531 0.0527
Echinococcus multilocularis fmrfamide receptor 0.0026 0.0324 0.0319
Echinococcus granulosus glutamate receptor 2 0.0035 0.049 0.0485
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0324 0.0319
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Trichomonas vaginalis D-aminoacylase, putative 0.0043 0.0675 0.1433
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0035 0.049 0.0485
Toxoplasma gondii ABC1 family protein 0.0043 0.0675 0.101
Loa Loa (eye worm) major facilitator superfamily transporter 0.0029 0.0383 0.0381
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0104 0.1932 0.3374
Loa Loa (eye worm) hypothetical protein 0.0033 0.0467 0.0474
Echinococcus multilocularis glutamate receptor 2 0.0035 0.049 0.0485
Toxoplasma gondii lysine-tRNA ligase 0.0023 0.0249 0.0258
Loa Loa (eye worm) hypothetical protein 0.0035 0.049 0.0498
Mycobacterium ulcerans lysyl-tRNA synthetase 0.0023 0.0249 0.3686
Onchocerca volvulus 0.0029 0.0383 0.086
Brugia malayi hypothetical protein 0.0026 0.0324 0.0418
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0031 0.0425 0.3184
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0324 0.0319
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0026 0.0324 0.0316
Trichomonas vaginalis sugar transporter, putative 0.0029 0.0383 0.0701
Brugia malayi hypothetical protein 0.0026 0.0324 0.0418
Echinococcus granulosus rhodopsin orphan GPCR 0.0026 0.0324 0.0319
Trichomonas vaginalis lysyl-tRNA synthetase, putative 0.002 0.019 0.022
Echinococcus granulosus importin subunit beta 1 0.0028 0.0361 0.0356
Schistosoma mansoni hypothetical protein 0.006 0.1009 0.1004
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0095 0.0065
Echinococcus multilocularis glutamyl tRNA synthetase cytoplasmic 0.0031 0.0412 0.0407
Schistosoma mansoni hypothetical protein 0.0015 0.0095 0.0091
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0026 0.0324 0.0316
Trypanosoma brucei hypothetical protein, conserved 0.0043 0.0675 0.5654
Loa Loa (eye worm) G-protein coupled receptor 0.0026 0.0324 0.0316
Echinococcus multilocularis calcium dependent protein kinase 0.0029 0.0385 0.038
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0026 0.0324 0.0319
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0016 0.0103 0.1522
Plasmodium vivax mitogen-activated protein kinase 2, putative 0.0166 0.3205 0.3574
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.4578 0.4575
Trichomonas vaginalis sugar transport protein, putative 0.0029 0.0383 0.0701
Echinococcus granulosus tm gpcr rhodopsin 0.0026 0.0324 0.0319
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0035 0.049 0.0485
Trichomonas vaginalis glucose transporter, putative 0.0065 0.1115 0.2535
Schistosoma mansoni protein kinase 0.0031 0.0425 0.0421
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0043 0.0675 0.1056
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.0383 0.0701
Trichomonas vaginalis penicillin-binding protein, putative 0.0043 0.0675 0.1433
Echinococcus multilocularis somatostatin receptor 0.0026 0.0324 0.0319
Mycobacterium tuberculosis Lysyl-tRNA synthetase 2 LysX 0.0019 0.0177 0.0138
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0035 0.049 0.0485
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0026 0.0324 0.0319
Schistosoma mansoni hypothetical protein 0.0166 0.3217 0.3214
Echinococcus granulosus allatostatin A receptor 0.0026 0.0324 0.0319
Echinococcus granulosus glutamyl tRNA synthetase cytoplasmic 0.0031 0.0412 0.0407
Mycobacterium ulcerans esterase/lipase LipP 0.0043 0.0675 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0026 0.0324 0.0319
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0026 0.0324 0.0319
Trypanosoma brucei ISWI complex protein 0.0018 0.0157 0.0541
Loa Loa (eye worm) hypothetical protein 0.0026 0.0324 0.0316
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0031 0.0425 0.0421
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0026 0.0324 0.0316
Echinococcus granulosus g protein coupled receptor 0.0026 0.0324 0.0319
Mycobacterium tuberculosis Probable oxidoreductase 0.0116 0.2173 0.3818
Schistosoma mansoni importin beta-1 0.0028 0.0361 0.0356
Mycobacterium ulcerans lipase LipD 0.0043 0.0675 1
Brugia malayi CXXC zinc finger family protein 0.0035 0.0493 0.0648
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0209 0.4096 0.4093
Brugia malayi neuropeptide F receptor 0.0026 0.0324 0.0418
Trypanosoma cruzi hexose transporter, putative 0.0029 0.0383 0.2764
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0721 0.114
Trichomonas vaginalis ran, putative 0.0021 0.0206 0.0259
Leishmania major hypothetical protein, conserved 0.0025 0.0287 0.1821
Loa Loa (eye worm) neuropeptide F receptor 0.0026 0.0324 0.0316
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0721 0.0712
Echinococcus multilocularis neuropeptides capa receptor 0.0026 0.0324 0.0319
Mycobacterium tuberculosis Probable conserved integral membrane transport protein 0.0029 0.0383 0.0516
Brugia malayi Bromodomain containing protein 0.0093 0.1691 0.2276
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0788 0.1049
Trypanosoma cruzi ISWI complex protein 0.0018 0.0157 0.0541
Loa Loa (eye worm) hypothetical protein 0.0035 0.049 0.0498
Brugia malayi beta-lactamase family protein 0.0043 0.0675 0.0896
Echinococcus multilocularis solute carrier family 2 facilitated glucose 0.0209 0.4096 0.4093
Trypanosoma cruzi hexose transporter, putative 0.0035 0.0507 0.3998
Onchocerca volvulus 0.0029 0.0383 0.086

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 0.3381 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 0.3548 um PUBCHEM_BIOASSAY: qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent). (Class of assay: confirmatory) [Related pubchem assays: 1002 (Confirmation Concentration-Response Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent)), 585 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) - a screen old NIH MLSMR collection), 584 (Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) - a screen of the old NIH MLSMR collection), 1003 (Confirmation Cuvette-Based Assay for Inhibitors of AmpC Beta-Lactamase (assay with detergent))] ChEMBL. No reference
Potency (functional) 1.6944 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 3.5481 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 7.0795 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins. (Class of assay: confirmatory) [Related pubchem assays: 1011 (Confirmation Concentration-Response Assay for Inhibitors of the Schistosoma mansoni Redox Cascade ), 448 (Schistosoma Mansoni Peroxiredoxins (Prx2) and thioredoxin glutathione reductase (TGR) coupled assay)] ChEMBL. No reference
Potency (functional) 10 uM PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of BAZ2B. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504391] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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