Detailed information for compound 178694

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 248.301 | Formula: C12H12N2O2S
  • H donors: 3 H acceptors: 2 LogP: 1.81 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: ONC(=O)C1Sc2cccc3c2c(C1C)c[nH]3
  • InChi: 1S/C12H12N2O2S/c1-6-7-5-13-8-3-2-4-9(10(7)8)17-11(6)12(15)14-16/h2-6,11,13,16H,1H3,(H,14,15)
  • InChiKey: JHEGDBXEWZGMDP-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0017 0.0017
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0077 0.0125
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0064 0.0427 0.043
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0039 0.0228 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0012 0.0017 0.0051
Onchocerca volvulus 0.0012 0.002 0.0066
Onchocerca volvulus 0.0012 0.002 0.0066
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0021
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0077 0.0282
Echinococcus granulosus serine:threonine protein kinase Chk2 0.0049 0.0306 0.0306
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0012 0.0017 0.0014
Trichomonas vaginalis leucine-rich transmembrane proteins, putative 0.001 0.0006 0.0011
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0017 0.0017
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0097 0.0681 0.0682
Schistosoma mansoni ste20-related kinase 0.0767 0.5921 0.9549
Brugia malayi ecdysteroid receptor 0.0012 0.0017 0.0014
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0077 0.0282
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0025 0.0118 0.0112
Echinococcus granulosus RUN 0.0023 0.0104 0.0104
Trichomonas vaginalis set domain proteins, putative 0.0276 0.2085 0.7955
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0219 0.1634 0.1646
Toxoplasma gondii HEAT repeat-containing protein 0.0034 0.0187 0.2128
Plasmodium vivax pyruvate kinase 2, putative 0.002 0.0081 0.0295
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0006 0.0016
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0104 0.0105
Echinococcus multilocularis leucine rich repeat serine:threonine protein 0.1281 0.9932 1
Echinococcus granulosus pyruvate kinase 0.0039 0.0228 0.0228
Trichomonas vaginalis STE family protein kinase 0.0345 0.262 1
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0119 0.0857 0.1381
Echinococcus multilocularis leucine rich repeat containing protein 23 0.0012 0.002 0.002
Toxoplasma gondii histone lysine methyltransferase SET1 0.0065 0.043 0.4981
Brugia malayi F/Y-rich N-terminus family protein 0.0011 0.0015 0.0011
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0012 0.0017 0.0027
Trypanosoma cruzi protein phosphatase 1, regulatory subunit, putative 0.0012 0.002 0.0094
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0011 0.0008 0.0008
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0012 0.0017 0.0011
Brugia malayi Protein kinase domain containing protein 0.0011 0.0008 0.0005
Onchocerca volvulus 0.0035 0.0202 0.0942
Onchocerca volvulus 0.0019 0.0077 0.0341
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0077 0.0282
Trichomonas vaginalis protein phosphatases pp1 regulatory subunit, putative 0.001 0.0006 0.0011
Echinococcus granulosus dual specificity testis-specific protein kinase 0.0013 0.0029 0.0029
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0505 0.2845
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0351 0.1969
Onchocerca volvulus Bile acid receptor homolog 0.0012 0.0017 0.0051
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.0011 0.0008 0.0008
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0261 0.1462
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0119 0.0857 0.0862
Trichomonas vaginalis protein phosphatases pp1 regulatory subunit, putative 0.0012 0.002 0.0064
Echinococcus granulosus tyrosine protein kinase Src64B 0.0011 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0056 0.0359 0.0355
Trypanosoma cruzi dynein light chain, putative 0.001 0.0006 0.0016
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0077 0.0078
Echinococcus granulosus geminin 0.0197 0.1466 0.1466
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0119 0.0857 0.1381
Chlamydia trachomatis pyruvate kinase 0.0039 0.0228 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0077 0.0282
Trichomonas vaginalis toll, putative 0.0012 0.002 0.0064
Trypanosoma cruzi leucine rich repeat protein, putative 0.001 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0054 0.0351 0.0347
Echinococcus multilocularis histone acetyltransferase MYST2 0.0063 0.0419 0.0422
Plasmodium falciparum cysteine proteinase falcipain 3 0.0019 0.0077 0.0282
Echinococcus multilocularis serine:threonine protein kinase 3 0.0995 0.7703 0.7756
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0077 0.0282
Echinococcus granulosus tyrosine protein kinase Srms 0.0011 0.0008 0.0008
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0505 0.2845
Echinococcus granulosus tyrosine kinase 0.0011 0.0008 0.0008
Brugia malayi Importin beta-1 subunit 0.0034 0.0187 0.0185
Schistosoma mansoni tyrosine kinase 0.0011 0.0008 0.0013
Onchocerca volvulus 0.0013 0.0027 0.0099
Schistosoma mansoni peptidase 0.0011 0.0012 0.0019
Loa Loa (eye worm) hypothetical protein 0.0043 0.0261 0.0257
Onchocerca volvulus 0.0023 0.0104 0.0471
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0006 0.0016
Echinococcus multilocularis leucine rich repeat and coiled coil 0.001 0.0006 0.0007
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0012 0.0017 0.0011
Onchocerca volvulus 0.0023 0.0104 0.0471
Brugia malayi Melibiase family protein 0.0079 0.0546 0.0547
Trypanosoma brucei pyruvate kinase 1, putative 0.0039 0.0228 0.1275
Mycobacterium leprae Probable pyruvate kinase PykA 0.0039 0.0228 1
Echinococcus granulosus cysteine protease 0.001 0.0004 0.0004
Schistosoma mansoni tyrosine kinase 0.0011 0.0008 0.0013
Brugia malayi Cathepsin L-like precursor 0.0019 0.0077 0.0074
Trypanosoma brucei pyruvate kinase 1 0.0039 0.0228 0.1275
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0228 0.086
Entamoeba histolytica protein kinase, putative 0.0013 0.0024 0.0078
Echinococcus multilocularis FTZ F1 alpha 0.0012 0.0017 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0012 0.0017 0.0014
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0382 0.2911 0.2926
Brugia malayi Cathepsin L-like precursor 0.0019 0.0077 0.0074
Echinococcus multilocularis cysteine protease 0.0019 0.0077 0.0078
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0228 0.1068
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0064 0.0427 0.0427
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0012 0.0017 0.0014
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0228 0.0224
Echinococcus multilocularis thyroid hormone receptor alpha 0.0012 0.0017 0.0017
Echinococcus granulosus c src tyrosine kinase 0.0011 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0027 0.009
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0017 0.0057 0.0092
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0027 0.0138 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0351 0.1969
Brugia malayi RNA, U transporter 1 0.0095 0.0671 0.0672
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0012 0.0017 0.0017
Brugia malayi Protein kinase domain containing protein 0.0382 0.2911 0.2928
Brugia malayi Cathepsin L-like precursor 0.0019 0.0077 0.0074
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0043 0.0261 0.0422
Echinococcus multilocularis leucine rich repeat containing protein 57 0.0012 0.002 0.002
Leishmania major pyruvate kinase 0.0039 0.0228 0.1261
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0017 0.0027
Loa Loa (eye worm) pyruvate kinase-PB 0.0027 0.0137 0.0131
Onchocerca volvulus 0.0033 0.0186 0.0865
Loa Loa (eye worm) hypothetical protein 0.0035 0.0202 0.0197
Echinococcus multilocularis protein phosphatase 1 regulatory subunit 7 0.001 0.0006 0.0007
Brugia malayi Cathepsin L-like precursor 0.0019 0.0077 0.0074
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0068 0.0455 0.2559
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0011 0.0008 0.0017
Plasmodium falciparum pyruvate kinase 0.0039 0.0228 0.086
Onchocerca volvulus 0.0011 0.0008 0.0008
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0029 0.0142
Onchocerca volvulus 0.0011 0.0008 0.0008
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0012 0.0017 0.0017
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0012 0.0017 0.0017
Brugia malayi CXXC zinc finger family protein 0.0033 0.0186 0.0184
Giardia lamblia Leucine-rich repeat protein 0.0012 0.002 0.0078
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0012 0.0016 0.0016
Schistosoma mansoni ran 0.0025 0.0118 0.019
Giardia lamblia Kinase, STE STE20 0.0236 0.1767 1
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0505 0.2845
Brugia malayi SH2 domain containing protein 0.0011 0.0008 0.0005
Echinococcus multilocularis cathepsin L cysteine protease 0.0019 0.0077 0.0078
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0011
Trichomonas vaginalis conserved hypothetical protein 0.0054 0.0351 0.1327
Echinococcus granulosus pyruvate kinase 0.002 0.0081 0.0081
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0077 0.0341
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0012 0.002 0.0064
Trypanosoma brucei AIR9-like protein 0.001 0.0006 0.0016
Loa Loa (eye worm) histone methyltransferase 0.0012 0.0016 0.001
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0063 0.0419 0.0419
Schistosoma mansoni lipoxygenase 0.0023 0.0104 0.0168
Trichomonas vaginalis protein phosphatases pp1 regulatory subunit, putative 0.001 0.0006 0.0011
Brugia malayi Papain family cysteine protease containing protein 0.0019 0.0077 0.0074
Brugia malayi Leucine Rich Repeat family protein 0.001 0.0006 0.0003
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0228 0.0224
Schistosoma mansoni myelin transcription factor 1 myt1 0.0063 0.0419 0.0676
Entamoeba histolytica Ran family GTPase 0.0025 0.0118 0.0438
Trypanosoma cruzi Rab-like 5, small G protein 0.0054 0.0351 0.1969
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0017 0.0014
Schistosoma mansoni calpain 4 6 7 invertebrate 0.001 0.0006 0.001
Plasmodium vivax pyruvate kinase, putative 0.0039 0.0228 0.086
Echinococcus multilocularis pyruvate kinase 0.0031 0.0165 0.0166
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0027 0.0138 0.1545
Echinococcus multilocularis GTP binding protein Parf 0.0054 0.0351 0.0353
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0012 0.0017 0.0011
Loa Loa (eye worm) hypothetical protein 0.0054 0.0351 0.0347
Echinococcus granulosus tyrosine protein kinase Fyn 0.0011 0.0008 0.0008
Trichomonas vaginalis GTP binding protein rare7l, putative 0.0054 0.0351 0.1327
Echinococcus multilocularis pyruvate kinase 0.0039 0.0228 0.023
Echinococcus multilocularis activin receptor type 0.0013 0.0029 0.0029
Trypanosoma brucei STE20-like serine/threonine-protein kinase 1, putative 0.0236 0.1767 1
Onchocerca volvulus 0.0011 0.0008 0.0008
Echinococcus granulosus ubiquitin specific protease 41 0.0043 0.0261 0.0261
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0202 0.2304
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0202 0.0204
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0011 0.0008 0.0008
Brugia malayi Protein kinase domain containing protein 0.0011 0.0008 0.0005
Echinococcus granulosus nischarin 0.001 0.0006 0.0006
Plasmodium falciparum protein kinase, putative 0.0013 0.0029 0.0096
Schistosoma mansoni protein kinase 0.0013 0.0029 0.0046
Entamoeba histolytica hypothetical protein 0.0054 0.0351 0.1327
Schistosoma mansoni RAR-like nuclear receptor 0.0012 0.0017 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0077 0.0282
Schistosoma mansoni lipoxygenase 0.0064 0.0427 0.0689
Mycobacterium ulcerans pyruvate kinase 0.0039 0.0228 1
Echinococcus granulosus serine threonine protein kinase 0.0345 0.262 0.262
Echinococcus multilocularis leucine rich repeat containing protein 9 0.001 0.0006 0.0007
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0261 0.0986
Echinococcus multilocularis c src tyrosine kinase 0.0011 0.0008 0.0008
Schistosoma mansoni hypothetical protein 0.0023 0.0104 0.0168
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0012 0.0017 0.0017
Entamoeba histolytica protein kinase, putative 0.0049 0.0306 0.1155
Brugia malayi SRC-1 0.0011 0.0008 0.0005
Trypanosoma brucei ULK family serine/threonine-protein kinase, putative 0.0014 0.0034 0.0175
Entamoeba histolytica hypothetical protein 0.0016 0.005 0.0179
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0077 0.0282
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0019 0.0077 0.0071
Trichomonas vaginalis protein phosphatase 2C, putative 0.001 0.0006 0.0011
Echinococcus multilocularis dual specificity testis specific protein kinase 0.0013 0.0029 0.0029
Trypanosoma brucei dynein light chain 1, axonemal 0.001 0.0006 0.0016
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0063 0.0419 0.0418
Schistosoma mansoni hypothetical protein 0.001 0.0006 0.001
Echinococcus multilocularis cell polarity protein leucine rich repeat 0.0012 0.002 0.002
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0138 0.0513
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0077 0.0282
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0202 0.0204
Trypanosoma brucei protein kinase, putative 0.0013 0.0029 0.0142
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0004 0.0006
Echinococcus multilocularis pyruvate kinase 0.002 0.0081 0.0081
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0008 0.0002
Schistosoma mansoni nuclear hormone receptor 0.0012 0.0017 0.0027
Trichomonas vaginalis conserved hypothetical protein 0.0043 0.0261 0.0986
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0261 0.0263
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0012 0.0017 0.0017
Echinococcus multilocularis serine threonine protein kinase 0.0345 0.262 0.2638
Brugia malayi SH2 domain containing protein 0.0011 0.0008 0.0005
Leishmania major cathepsin L-like protease 0.0019 0.0077 0.0403
Onchocerca volvulus 0.0011 0.0008 0.0008
Loa Loa (eye worm) TK protein kinase 0.0011 0.0008 0.0002
Leishmania major cysteine peptidase A (CPA) 0.0019 0.0077 0.0403
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0228 0.1068
Leishmania major protein kinase, putative 0.0013 0.0029 0.0126
Schistosoma mansoni sex comb on midleg homolog 0.0056 0.0359 0.0579
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0025 0.0118 0.1313
Loa Loa (eye worm) pyruvate kinase 0.0039 0.0228 0.0224
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0118 0.065
Entamoeba histolytica SH2-protein kinase domain containing protein 0.0013 0.0024 0.0078
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0012 0.0017 0.0017
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0008 0.0002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0012 0.0017 0.0014
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0138 0.0513
Onchocerca volvulus 0.0019 0.0077 0.0341
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0012 0.0017 0.0017
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0021
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0043 0.0261 0.0422
Plasmodium vivax protein phosphatases PP1 regulatory subunit sds22, putative 0.0012 0.002 0.0064
Trypanosoma brucei hypothetical protein, conserved 0.0027 0.0138 0.0761
Echinococcus multilocularis pyruvate kinase 0.0039 0.0228 0.023
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0077 0.0282
Leishmania major hypothetical protein, conserved 0.0012 0.002 0.0078
Trichomonas vaginalis pyruvate kinase, putative 0.0039 0.0228 0.086
Brugia malayi photoreceptor-specific nuclear receptor 0.0012 0.0017 0.0014
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0104 0.0105
Trypanosoma cruzi cysteine peptidase, putative 0.0019 0.0077 0.0419
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0008 0.0002
Leishmania major cathepsin L-like protease 0.0074 0.0505 0.2833
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0011
Echinococcus granulosus pyruvate kinase 0.002 0.0081 0.0081
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0104 0.0104
Schistosoma mansoni cpg binding protein 0.0033 0.0186 0.03
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0104 0.0386
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0029 0.0142
Trichomonas vaginalis TKL family protein kinase 0.0016 0.005 0.0179
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0077 0.0282
Onchocerca volvulus Protein ultraspiracle homolog 0.0012 0.0017 0.0051
Schistosoma mansoni hypothetical protein 0.0197 0.1466 0.2364
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0138 0.0761
Echinococcus granulosus tyrosine protein kinase shark 0.0011 0.0008 0.0008
Toxoplasma gondii leucine-rich repeat protein LRR1 0.0012 0.002 0.0162
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0025 0.0118 0.065
Echinococcus multilocularis nischarin 0.001 0.0006 0.0007
Brugia malayi hypothetical protein 0.0054 0.0351 0.035
Brugia malayi cathepsin L-like precursor 0.0013 0.0027 0.0024
Schistosoma mansoni hypothetical protein 0.0337 0.2562 0.4132
Echinococcus multilocularis geminin 0.0197 0.1466 0.1476
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0505 0.2845
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0063 0.0419 0.0422
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0011 0.0008 0.0008
Onchocerca volvulus 0.0276 0.2085 1
Echinococcus granulosus SAM and MBT domain containing protein 0.0056 0.0359 0.0359
Loa Loa (eye worm) hypothetical protein 0.0034 0.0187 0.0182
Onchocerca volvulus Mitochondrial Rho GTPase homolog 0.0054 0.0351 0.1657
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0025 0.0118 0.065
Onchocerca volvulus 0.0097 0.0681 0.3246
Leishmania major cathepsin L-like protease 0.0019 0.0077 0.0403
Brugia malayi Pre-SET motif family protein 0.0035 0.0202 0.02
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0025 0.0118 0.0438
Echinococcus granulosus cathepsin L cysteine protease 0.001 0.0004 0.0004
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0011
Brugia malayi Tyrosine-protein kinase abl-1 0.0011 0.0008 0.0005
Loa Loa (eye worm) hypothetical protein 0.0054 0.0351 0.0347
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0025 0.0118 0.0634
Echinococcus multilocularis calcium:calmodulin dependent protein kinase I 0.0049 0.0306 0.0308
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0119 0.0857 0.1381
Schistosoma mansoni retinoic acid receptor RXR 0.0012 0.0017 0.0027
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0077 0.0282
Entamoeba histolytica serine/threonine-protein kinase 3, putative 0.0236 0.1767 0.6741
Brugia malayi Protein kinase domain containing protein 0.0011 0.0008 0.0005
Echinococcus multilocularis rab protein 3 0.0054 0.0351 0.0353
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0012 0.0017 0.0017
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.0013 0.0029 0.0261
Entamoeba histolytica protein kinase, putative 0.0345 0.262 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0025 0.0118 0.0115
Leishmania major phosphopantetheinyl transferase-like protein 0.0027 0.0138 0.0746
Plasmodium vivax ras-related protein Rab-5A, putative 0.0054 0.0351 0.1327
Schistosoma mansoni tyrosine kinase 0.0011 0.0008 0.0013
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0011
Echinococcus granulosus L aminoadipate semialdehyde 0.0097 0.0681 0.0681
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0012 0.0017 0.0027
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0505 0.2845
Trichomonas vaginalis protein phosphatase 2C, putative 0.001 0.0006 0.0011
Brugia malayi Leucine Rich Repeat family protein 0.0012 0.002 0.0017
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0261 0.0263
Entamoeba histolytica pyruvate kinase, putative 0.0027 0.0137 0.0509
Trichomonas vaginalis protein phosphatases pp1 regulatory subunit, putative 0.001 0.0006 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0077 0.0282
Echinococcus granulosus tyrosine protein kinase Lyn 0.0018 0.0068 0.0068
Schistosoma mansoni pyruvate kinase 0.0039 0.0228 0.0368
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0306 0.0493
Onchocerca volvulus 0.0019 0.0077 0.0341
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0138 0.0513
Echinococcus granulosus tyrosine protein kinase ABL1 0.0011 0.0008 0.0008
Echinococcus multilocularis pyruvate kinase 0.002 0.0081 0.0081
Trichomonas vaginalis protein phosphatases pp1 regulatory subunit, putative 0.001 0.0006 0.0011
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0243 0.1823 0.183
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0019 0.0077 0.0282
Schistosoma mansoni serine/threonine protein kinase 0.0382 0.2911 0.4695
Brugia malayi Protein kinase domain containing protein 0.0011 0.0008 0.0005
Entamoeba histolytica hypothetical protein 0.0027 0.0138 0.0513
Plasmodium vivax SET domain protein, putative 0.0035 0.0202 0.076
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0012 0.0017 0.0027
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0004 0.0006
Brugia malayi RAB, member of RAS oncogene family-like 5 0.0054 0.0351 0.035
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0008 0.0002
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0012 0.0017 0.0011
Toxoplasma gondii pyruvate kinase PyK1 0.0039 0.0228 0.2612
Trypanosoma brucei leucine-rich repeat protein (LRRP), putative 0.001 0.0006 0.0016
Echinococcus granulosus polycomb protein SCMH1 0.0056 0.0359 0.0359
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0008 0.0002
Trichomonas vaginalis leucine-rich repeat containing protein, putative 0.001 0.0006 0.0011
Echinococcus multilocularis serine:threonine protein kinase Chk2 0.0049 0.0306 0.0308
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0104 0.0386
Schistosoma mansoni steroid hormone receptor ad4bp 0.0012 0.0017 0.0027
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0012 0.0017 0.0027
Onchocerca volvulus 0.0019 0.0077 0.0341
Schistosoma mansoni hypothetical protein 0.0054 0.0351 0.0566
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0077 0.0078
Echinococcus multilocularis microtubule associated protein 2 0.0803 0.62 0.6243
Trichomonas vaginalis protein phosphatases pp1 regulatory subunit, putative 0.001 0.0006 0.0011
Echinococcus granulosus tyrosine protein kinase Fps85D 0.0011 0.0008 0.0008
Echinococcus granulosus cathepsin l1 0.0013 0.0027 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0017 0.0014
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0012 0.0017 0.0017
Brugia malayi hypothetical protein 0.0011 0.0008 0.0005
Entamoeba histolytica cysteine protease, putative 0.0019 0.0077 0.0282
Onchocerca volvulus Cathepsin L homolog 0.0019 0.0077 0.0341
Giardia lamblia Pyruvate kinase 0.002 0.0081 0.0422
Echinococcus multilocularis importin subunit beta 1 0.0034 0.0187 0.0189
Echinococcus granulosus cathepsin L cysteine proteinase 0.0019 0.0077 0.0077
Trypanosoma cruzi hypothetical protein, conserved 0.001 0.0006 0.0016
Onchocerca volvulus 0.0019 0.0077 0.0341
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0011 0.0008 0.0008
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.0011 0.0008 0.0008
Echinococcus multilocularis tyrosine protein kinase Fgr 0.0011 0.0008 0.0008
Loa Loa (eye worm) hypothetical protein 0.0097 0.0681 0.068
Schistosoma mansoni protein kinase 0.0013 0.0029 0.0046
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0505 0.2845
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0505 0.2845
Echinococcus multilocularis polycomb protein SCMH1 0.0056 0.0359 0.0361
Echinococcus granulosus rab protein 3 0.0054 0.0351 0.0351
Loa Loa (eye worm) steroid hormone receptor 0.0012 0.0017 0.0011
Echinococcus granulosus cathepsin L 0.001 0.0004 0.0004
Echinococcus multilocularis cpg binding protein 0.0035 0.0201 0.0203
Brugia malayi nuclear hormone receptor 0.0012 0.0017 0.0014
Brugia malayi Cathepsin L-like cysteine proteinase 0.0013 0.0027 0.0024
Plasmodium vivax serine/threonine-specific protein kinase, putative 0.0345 0.262 1
Echinococcus granulosus tyrosine protein kinase Src42A 0.0011 0.0008 0.0008
Entamoeba histolytica serine/threonine protein kinase STE20, putative 0.0236 0.1767 0.6741
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0077 0.0282
Echinococcus granulosus cathepsin l cysteine peptidase 0.0019 0.0077 0.0077
Echinococcus granulosus tyrosine protein kinase Fyn 0.0011 0.0008 0.0008
Toxoplasma gondii Alpha-galactosidase 0.0017 0.0057 0.0594
Leishmania major cathepsin L-like protease 0.0019 0.0077 0.0403
Leishmania major cathepsin L-like protease 0.0019 0.0077 0.0403
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0104 0.0104
Schistosoma mansoni loxhd1 0.0023 0.0104 0.0168
Toxoplasma gondii cathepsin CPL 0.0019 0.0077 0.0834
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0012 0.0017 0.0017
Brugia malayi protein-tyrosine kinase 0.0011 0.0008 0.0005
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0011 0.0008 0.0008
Schistosoma mansoni tyrosine kinase 0.0011 0.0008 0.0013
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.0011 0.0008 0.0008
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0008 0.0002
Brugia malayi Pyruvate kinase, muscle isozyme 0.0039 0.0228 0.0227
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0011 0.0008 0.0008
Echinococcus multilocularis tyrosine kinase 0.0011 0.0008 0.0008
Schistosoma mansoni cpg binding protein 0.0035 0.0201 0.0324
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0104 0.0105
Trypanosoma cruzi hypothetical protein, conserved 0.0054 0.0351 0.1969
Loa Loa (eye worm) TK/ABL protein kinase 0.0011 0.0008 0.0002
Loa Loa (eye worm) hypothetical protein 0.0063 0.0419 0.0416
Trichomonas vaginalis protein phosphatases pp1 regulatory subunit, putative 0.001 0.0006 0.0011
Schistosoma mansoni rab6-interacting 0.0023 0.0104 0.0168
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0077 0.0282
Onchocerca volvulus 0.0019 0.0077 0.0341
Loa Loa (eye worm) ctsf protein 0.0019 0.0077 0.0071
Schistosoma mansoni hypothetical protein 0.0476 0.3645 0.5878
Brugia malayi mbt repeat family protein 0.0056 0.0359 0.0358
Trichomonas vaginalis ran, putative 0.0025 0.0118 0.0438
Brugia malayi nuclear receptor NHR-88 0.0012 0.0017 0.0014
Echinococcus multilocularis neuropeptide s receptor 0.0538 0.413 0.4158
Schistosoma mansoni coup transcription factor 0.0012 0.0017 0.0027
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0012 0.0017 0.0014
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0027 0.0138 0.0513
Echinococcus multilocularis myosin iiia 0.0236 0.1767 0.1779
Schistosoma mansoni protein kinase 0.0013 0.0029 0.0046
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.0013 0.0029 0.0142
Echinococcus multilocularis tyrosine protein kinase shark 0.0011 0.0008 0.0008
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0104 0.0104
Onchocerca volvulus Pyruvate kinase homolog 0.0039 0.0228 0.1068
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0202 0.0326
Echinococcus multilocularis cysteine protease 0.0019 0.0077 0.0078
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0187 0.1042
Echinococcus granulosus neuropeptide receptor A26 0.0538 0.413 0.413
Entamoeba histolytica hypothetical protein 0.0027 0.0138 0.0513
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0104 0.0099
Loa Loa (eye worm) hypothetical protein 0.0079 0.0546 0.0544
Plasmodium vivax leucine-rich repeat protein 0.001 0.0006 0.0011
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0011
Entamoeba histolytica protein kinase domain containing protein 0.0013 0.0029 0.0096
Trichomonas vaginalis protein phosphatases pp1 regulatory subunit, putative 0.001 0.0006 0.0011
Brugia malayi Cathepsin L-like precursor 0.0019 0.0077 0.0074
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0219 0.1634 0.1634
Brugia malayi Protein kinase domain containing protein 0.1281 0.9932 1
Echinococcus granulosus cpg binding protein 0.0035 0.0201 0.0201
Trichomonas vaginalis STE family protein kinase 0.0236 0.1767 0.6741
Loa Loa (eye worm) CXXC zinc finger family protein 0.0033 0.0186 0.0181
Brugia malayi Doublecortin family protein 0.0023 0.0104 0.0102
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0228 0.1275
Brugia malayi hypothetical protein 0.0023 0.0104 0.0102
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0012 0.0016 0.0016
Leishmania major hypothetical protein, conserved 0.0054 0.0351 0.1956
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.0011 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0077 0.0282
Brugia malayi Pre-SET motif family protein 0.0243 0.1823 0.1833
Trypanosoma cruzi major cysteine proteinase, putative 0.0058 0.0381 0.2141
Plasmodium vivax vivapain-2 0.0019 0.0077 0.0282
Leishmania major hypothetical protein, conserved 0.0054 0.0351 0.1956
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0072 0.0489 0.0789
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0505 0.2845
Echinococcus granulosus microtubule associated protein 2 0.0803 0.62 0.62
Echinococcus multilocularis dnaJ subfamily B 0.0476 0.3645 0.3669
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0012 0.0017 0.0027
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0043 0.0261 0.1448
Leishmania major cathepsin L-like protease 0.0074 0.0505 0.2833
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0008 0.0002
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0079 0.0546 0.0881
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0236 0.1767 1
Echinococcus multilocularis L aminoadipate semialdehyde 0.0097 0.0681 0.0686
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0202 0.0326
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0138 0.0513
Echinococcus granulosus calcium:calmodulin dependent protein kinase I 0.0049 0.0306 0.0306
Echinococcus granulosus pyruvate kinase 0.002 0.0081 0.0081
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0019 0.0077 0.0071
Plasmodium falciparum leucine-rich repeat protein 0.0012 0.002 0.0064
Echinococcus multilocularis ubiquitin specific protease 41 0.0043 0.0261 0.0263
Leishmania major importin beta-1 subunit, putative 0.0027 0.0138 0.0746
Echinococcus multilocularis SAM and MBT domain containing protein 0.0056 0.0359 0.0361
Echinococcus granulosus tyrosine protein kinase Blk 0.0011 0.0008 0.0008
Schistosoma mansoni pyruvate kinase 0.0039 0.0228 0.0368
Schistosoma mansoni ran 0.0025 0.0118 0.019
Echinococcus multilocularis tyrosine protein kinase Fyn 0.0011 0.0008 0.0008
Schistosoma mansoni microtubule-associated protein tau 0.0803 0.62 1
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0202 0.0326
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0012 0.0017 0.0011
Plasmodium falciparum protein kinase, putative 0.0345 0.262 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.001 0.0004 0.0006
Schistosoma mansoni hypothetical protein 0.001 0.0006 0.001
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0077 0.0282
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0202 0.0326
Loa Loa (eye worm) SRC-1 0.0011 0.0008 0.0002
Schistosoma mansoni thyroid hormone receptor 0.0012 0.0017 0.0027
Entamoeba histolytica hypothetical protein 0.0054 0.0351 0.1327
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0012 0.0017 0.0014
Loa Loa (eye worm) hypothetical protein 0.0039 0.0228 0.0224
Loa Loa (eye worm) hypothetical protein 0.0023 0.0104 0.0099
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0027 0.0138 0.5
Schistosoma mansoni tyrosine kinase 0.0011 0.0008 0.0013
Schistosoma mansoni hypothetical protein 0.0358 0.2724 0.4394
Brugia malayi Leucine Rich Repeat family protein 0.0012 0.002 0.0017
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0027 0.0138 0.1545
Brugia malayi mbt repeat family protein 0.0056 0.0359 0.0358
Loa Loa (eye worm) hypothetical protein 0.0023 0.0104 0.0099
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0077 0.0282
Echinococcus multilocularis ras-related protein rab-5 0.0054 0.0351 0.0353
Echinococcus granulosus cathepsin l1 0.0019 0.0077 0.0077
Plasmodium vivax importin-beta 2, putative 0.0034 0.0187 0.0702
Schistosoma mansoni cathepsin F (C01 family) 0.0019 0.0077 0.0125
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0012 0.0017 0.0014
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0505 0.2845
Schistosoma mansoni cathepsin F (C01 family) 0.0013 0.0027 0.0044
Giardia lamblia Pyruvate kinase 0.0039 0.0228 0.1261
Brugia malayi Cathepsin L-like precursor 0.0013 0.0027 0.0024
Loa Loa (eye worm) TKL/LRRK protein kinase 0.1281 0.9932 1
Loa Loa (eye worm) hypothetical protein 0.0011 0.0008 0.0002
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.0011 0.0008 0.0013
Trypanosoma cruzi dynein light chain, putative 0.001 0.0006 0.0016
Loa Loa (eye worm) hypothetical protein 0.0019 0.0077 0.0071
Trypanosoma cruzi STE/STE20 serine/threonine-protein kinase, putative 0.0236 0.1767 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0261 0.1462
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0077 0.0282
Brugia malayi Pyruvate kinase, alpha/beta domain containing protein 0.0012 0.0017 0.0013
Brugia malayi Cathepsin L-like precursor 0.0019 0.0077 0.0074
Echinococcus granulosus activin receptor type 0.0013 0.0029 0.0029
Echinococcus multilocularis tyrosine protein kinase Abl 0.0011 0.0008 0.0008
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0043 0.0261 0.1462
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0077 0.0282
Brugia malayi steroid hormone receptor 0.0012 0.0017 0.0014
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0043 0.0261 0.026
Brugia malayi Protein kinase domain containing protein 0.0011 0.0008 0.0005
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0012 0.0017 0.0011
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0008 0.0002
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0119 0.0857 0.0857
Echinococcus granulosus GTP binding protein Parf 0.0054 0.0351 0.0351
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0119 0.0857 0.1381
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.0011 0.0008 0.0008
Echinococcus granulosus tyrosine protein kinase Fyn 0.0011 0.0008 0.0008
Brugia malayi Steroid receptor seven-up type 2 0.0012 0.0017 0.0014
Trichomonas vaginalis hypothetical protein 0.0054 0.0351 0.1327
Echinococcus multilocularis neuropeptide receptor A26 0.0538 0.413 0.4158
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0021
Plasmodium falciparum importin beta, putative 0.0034 0.0187 0.0702
Onchocerca volvulus 0.0011 0.0008 0.0008
Onchocerca volvulus Cathepsin F homolog 0.0019 0.0077 0.0341
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0012 0.0017 0.0014
Loa Loa (eye worm) STE/STE20/MST protein kinase 0.0995 0.7703 0.7754
Onchocerca volvulus 0.0012 0.002 0.0066
Leishmania major cathepsin L-like protease 0.0074 0.0505 0.2833
Leishmania major GTP-binding protein, putative 0.0025 0.0118 0.0634
Brugia malayi Nuclear hormone receptor-like 1 0.0012 0.0017 0.0014
Onchocerca volvulus 0.0012 0.0017 0.0051
Echinococcus multilocularis tyrosine protein kinase Blk 0.0011 0.0008 0.0008
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0077 0.0282
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0056 0.0359 0.0579
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0077 0.0282
Echinococcus multilocularis cathepsin L 0.001 0.0004 0.0004
Trypanosoma brucei Rab-like 5, small G protein 0.0054 0.0351 0.1969
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0505 0.2845
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0043 0.0261 0.0986
Brugia malayi Leucine Rich Repeat family protein 0.001 0.0006 0.0003
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0025 0.0118 0.0119
Schistosoma mansoni tyrosine kinase 0.0011 0.0008 0.0013
Loa Loa (eye worm) MBCTL1 0.0063 0.0419 0.0416
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0043 0.0261 0.0261
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.0011 0.0008 0.0008
Leishmania major pyruvate kinase 0.0039 0.0228 0.1261
Echinococcus granulosus pyruvate kinase 0.0039 0.0228 0.0228
Schistosoma mansoni pyruvate kinase 0.002 0.0081 0.013
Schistosoma mansoni protein phosphatases pp1 regulatory subunit 0.001 0.0006 0.001
Schistosoma mansoni importin beta-1 0.0034 0.0187 0.0302
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0187 0.0187
Leishmania major protein kinase, putative 0.0236 0.1767 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0505 0.2845
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0056 0.0359 0.1696
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0019 0.0077 0.0282
Trypanosoma cruzi pyruvate kinase 2, putative 0.0039 0.0228 0.1275
Loa Loa (eye worm) fibroinase 0.0019 0.0077 0.0071
Loa Loa (eye worm) hypothetical protein 0.0027 0.0137 0.0131
Onchocerca volvulus 0.0056 0.0359 0.1696
Toxoplasma gondii pyruvate kinase PyKII 0.002 0.0081 0.0875
Onchocerca volvulus 0.0054 0.0351 0.1657
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0505 0.2845
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0043 0.0261 0.0986
Onchocerca volvulus Peroxidasin homolog 0.0012 0.002 0.0066
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0025 0.0118 0.0438
Echinococcus granulosus neuropeptide s receptor 0.0538 0.413 0.413
Leishmania major cathepsin L-like protease 0.0019 0.0077 0.0403
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0019 0.0077 0.0282
Trypanosoma cruzi cysteine peptidase, putative 0.0074 0.0505 0.2845
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0079 0.0546 0.2074
Plasmodium falciparum pyruvate kinase 2 0.002 0.0081 0.0295
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0358 0.2724 0.2738
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0074 0.0505 0.2845
Entamoeba histolytica leucine rich repeat and phosphatase domain containing protein 0.001 0.0006 0.0011
Plasmodium falciparum ras-related protein Rab-5A 0.0054 0.0351 0.1327
Echinococcus granulosus importin subunit beta 1 0.0034 0.0187 0.0187
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0019 0.0077 0.0282
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0011
Brugia malayi Pyruvate kinase, M2 isozyme 0.0039 0.0228 0.0227
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0043 0.0261 0.0261
Plasmodium vivax vivapain-2 0.0019 0.0077 0.0282
Schistosoma mansoni cpg binding protein 0.0035 0.0201 0.0324
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0013 0.0027 0.009
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0012 0.0017 0.0027
Trypanosoma cruzi cruzipain precursor, putative 0.0074 0.0505 0.2845
Schistosoma mansoni hypothetical protein 0.0197 0.1466 0.2364
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0019 0.0077 0.0078
Echinococcus granulosus GTP binding nuclear protein Ran 0.0025 0.0118 0.0118
Loa Loa (eye worm) STE/STE20/YSK protein kinase 0.0345 0.262 0.2633
Echinococcus granulosus tyrosine kinase 0.0011 0.0008 0.0008
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0012 0.0017 0.0017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0017 0.0014
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0008 0.0002
Trichomonas vaginalis conserved hypothetical protein 0.001 0.0006 0.0011
Brugia malayi hypothetical protein 0.0023 0.0104 0.0102
Plasmodium vivax hypothetical protein, conserved 0.001 0.0006 0.0011
Echinococcus multilocularis RUN 0.0023 0.0104 0.0105
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0079 0.0546 0.0881
Schistosoma mansoni serine/threonine protein kinase 0.0345 0.262 0.4225
Onchocerca volvulus 0.0011 0.0008 0.0008
Entamoeba histolytica protein kinase, putative 0.0049 0.0306 0.1155
Schistosoma mansoni protein phosphatases pp1 regulatory subunit 0.001 0.0006 0.001
Plasmodium vivax leucine-rich repeat protein 0.001 0.0006 0.0011
Brugia malayi Cathepsin L-like precursor 0.0013 0.0027 0.0024
Trichomonas vaginalis leucine-rich repeat-containing protein, putative 0.0012 0.002 0.0064
Echinococcus granulosus dnaJ subfamily B 0.0476 0.3645 0.3645
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0012 0.0017 0.0011
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0202 0.0202
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0012 0.0017 0.0014
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.0011 0.0008 0.0008
Onchocerca volvulus 0.0019 0.0077 0.0341
Entamoeba histolytica leucine-rich repeat containing protein 0.001 0.0006 0.0011
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0077 0.0282
Echinococcus multilocularis tyrosine protein kinase Src42A 0.0011 0.0008 0.0008
Echinococcus granulosus leucine rich repeat containing protein 23 0.0012 0.002 0.002
Echinococcus multilocularis tyrosine protein kinase Src64B 0.0011 0.0008 0.0008
Echinococcus multilocularis pyruvate kinase 0.002 0.0081 0.0081
Echinococcus granulosus histone acetyltransferase MYST2 0.0063 0.0419 0.0419
Schistosoma mansoni polycystin 1-related 0.0023 0.0104 0.0168
Entamoeba histolytica cysteine proteinase, putative 0.0019 0.0077 0.0282
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0012 0.0017 0.0014
Toxoplasma gondii melibiase subfamily protein 0.0119 0.0857 1
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0077 0.0282
Echinococcus multilocularis tyrosine protein kinase Srms 0.0011 0.0008 0.0008
Echinococcus multilocularis snurportin 1 0.0358 0.2724 0.2743
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0043 0.0261 0.1448
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0097 0.0681 0.1099
Echinococcus granulosus FTZ F1 alpha 0.0012 0.0017 0.0017
Schistosoma mansoni rab6-interacting 0.0023 0.0104 0.0168
Schistosoma mansoni sex comb on midleg homolog 0.0056 0.0359 0.0579
Echinococcus granulosus snurportin 1 0.0358 0.2724 0.2724
Entamoeba histolytica cysteine proteinase, putative 0.0013 0.0027 0.009
Trichomonas vaginalis STE family protein kinase 0.0345 0.262 1
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0011
Trichomonas vaginalis leucine-rich repeat-containing protein, putative 0.0012 0.002 0.0064
Schistosoma mansoni dynein light chain 0.001 0.0006 0.001
Echinococcus multilocularis ecdysone induced protein 78C 0.0012 0.0017 0.0017
Brugia malayi Leucine Rich Repeat family protein 0.001 0.0006 0.0003
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0119 0.0857 0.0862
Loa Loa (eye worm) cysteine protease 0.0019 0.0077 0.0071
Loa Loa (eye worm) mbt repeat family protein 0.0056 0.0359 0.0355
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0019 0.0077 0.0282
Brugia malayi Ras-related protein ypt4 0.0054 0.0351 0.035
Echinococcus granulosus ecdysone induced protein 78C 0.0012 0.0017 0.0017
Trypanosoma brucei importin beta-1 subunit, putative 0.0034 0.0187 0.1042
Brugia malayi STE20-like kinase MST 0.0995 0.7703 0.7755
Loa Loa (eye worm) hypothetical protein 0.0012 0.0017 0.0011
Echinococcus granulosus serine:threonine protein kinase 3 0.0995 0.7703 0.7703
Loa Loa (eye worm) TK/FER protein kinase 0.0011 0.0008 0.0002

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) NI 0 nM Compound was tested for inhibitory activity against tryptophanyl tRNA synthetase in Staphylococcus aureus; NI means no inhibition microM ChEMBL. 12372526

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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