Detailed information for compound 1791191

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 518.241 | Formula: C23H22Br2N2O2
  • H donors: 1 H acceptors: 1 LogP: 5.83 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cccc(c1)N(CC(Cn1c2ccc(cc2c2c1ccc(c2)Br)Br)O)C
  • InChi: 1S/C23H22Br2N2O2/c1-26(17-4-3-5-19(12-17)29-2)13-18(28)14-27-22-8-6-15(24)10-20(22)21-11-16(25)7-9-23(21)27/h3-12,18,28H,13-14H2,1-2H3
  • InChiKey: JTAMOOIVQBHINJ-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii heat shock protein 75, putative 0.0013 0.0138 0.0513
Trypanosoma brucei heat shock protein, putative 0.0052 0.0821 0.1183
Leishmania major heat shock protein 83-1 0.0052 0.0821 0.1183
Toxoplasma gondii P-type ATPase4, putative 0.0009 0.0064 0.0232
Mycobacterium ulcerans two component sensory transduction histidine kinase MtrB 0.0027 0.0383 0.0321
Schistosoma mansoni cpg binding protein 0.0032 0.0465 0.0461
Schistosoma mansoni pyruvate dehydrogenase 0.0348 0.5992 0.5991
Brugia malayi F/Y-rich N-terminus family protein 0.0009 0.0072 0.0046
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0009 0.0064 0.0094
Trypanosoma brucei Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0027 0.0383 0.0498
Brugia malayi Hsp90 protein 0.0013 0.0138 0.0112
Loa Loa (eye worm) hypothetical protein 0.009 0.1492 0.1489
Giardia lamblia Pms1-like protein 0.0027 0.0383 0.4211
Plasmodium vivax basic transcription factor 3b, putative 0.0036 0.0539 0.6566
Loa Loa (eye worm) RecQ helicase 0.0025 0.0343 0.034
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0138 0.0979
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0143 0.1737
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0009 0.0064 0.0232
Mycobacterium ulcerans two component sensor histidine kinase PrrB 0.0027 0.0383 0.0321
Echinococcus granulosus phospholipid transporting ATPase VA 0.0009 0.0064 0.0052
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0026 0.0322
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0009 0.0072 0.0069
Trypanosoma cruzi Calcium ATPase SERCA-like 0.0009 0.0064 0.0094
Trichomonas vaginalis helicase, putative 0.0007 0.0031 0.0005
Loa Loa (eye worm) glutaminase 2 0.0578 1 1
Toxoplasma gondii DNA topoisomerase 2, putative 0.0027 0.0383 0.1444
Loa Loa (eye worm) hypothetical protein 0.0009 0.0072 0.0069
Mycobacterium ulcerans two component regulator - sensor kinase 0.0027 0.0383 0.0321
Echinococcus multilocularis GPCR, family 2 0.0016 0.0186 0.0218
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0064 0.0052
Trypanosoma brucei heat shock protein, putative 0.0052 0.0821 0.1183
Loa Loa (eye worm) hypothetical protein 0.0007 0.0026 0.0023
Mycobacterium leprae TWO COMPONENT SENSOR HISTIDINE KINASE PRRB 0.0027 0.0383 1
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0776 0.0752
Plasmodium falciparum DNA topoisomerase 2 0.0027 0.0383 0.4211
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0026 0.0023
Loa Loa (eye worm) hypothetical protein 0.009 0.1492 0.1489
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0005
Treponema pallidum hypothetical protein 0.0009 0.0064 0.1605
Echinococcus granulosus ATP dependent DNA helicase Q1 0.001 0.009 0.0088
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0026 0.0023
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0009 0.0064 0.0784
Leishmania major heat shock protein 83-1 0.0052 0.0821 0.1183
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0025 0.0351 0.8999
Brugia malayi DIX domain containing protein 0.0009 0.0072 0.0046
Mycobacterium leprae Probable two component sensor kinase MprB 0.0027 0.0383 1
Leishmania major heat shock protein 83-1 0.0052 0.0821 0.1183
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0129 0.2163 0.3281
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0026 0.0322
Trichomonas vaginalis receptor histidine kinase, putative 0.0027 0.0383 0.0358
Trypanosoma cruzi DNA topoisomerase II, putative 0.0027 0.0383 0.0588
Schistosoma mansoni DNA topoisomerase II 0.0027 0.0383 0.038
Echinococcus granulosus cpg binding protein 0.0032 0.0465 0.0599
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0026 0.0322
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0025 0.0351 0.0444
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0009 0.0064 0.0094
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0027 0.0383 0.1444
Leishmania major heat shock protein 83-1 0.0052 0.0821 0.1183
Toxoplasma gondii heat shock protein HSP90 0.0052 0.0821 0.311
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0351 0.0326
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0072 0.0062
Mycobacterium tuberculosis Two component sensory transduction histidine kinase MtrB 0.0027 0.0383 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0005
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0064 0.0038
Echinococcus multilocularis dnaJ subfamily B 0.0426 0.7345 1
Loa Loa (eye worm) hypothetical protein 0.0375 0.6462 0.6461
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0005
Echinococcus multilocularis phospholipid transporting ATPase VA 0.0009 0.0064 0.0052
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0064 0.0038
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0026 0.0322
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0074 0.0066
Loa Loa (eye worm) hypothetical protein 0.0009 0.0064 0.0061
Plasmodium falciparum heat shock protein 90, putative 0.0013 0.0138 0.0979
Schistosoma mansoni regulator of G protein signaling 0.0009 0.0072 0.0069
Schistosoma mansoni cation-transporting atpase worm 0.0009 0.0064 0.0061
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0072 0.0062
Echinococcus multilocularis endoplasmin 0.0025 0.0351 0.0444
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0812 0.1074
Echinococcus granulosus endoplasmin 0.0025 0.0351 0.0444
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0007 0.0043 0.0022
Loa Loa (eye worm) sodium/potassium-transporting ATPase subunit alpha 0.0009 0.0064 0.0061
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0072 0.0062
Plasmodium vivax endoplasmin, putative 0.0052 0.0821 1
Entamoeba histolytica recQ family DNA helicase 0.0005 0.0003 0.0042
Schistosoma mansoni phosphoserine phosphatase 0.0009 0.0064 0.0061
Mycobacterium ulcerans two component sensor histidine kinase DevS 0.0027 0.0383 0.0321
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0185 0.3147 1
Brugia malayi Bloom's syndrome protein homolog 0.0025 0.0343 0.0317
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0186 0.0218
Echinococcus granulosus cation transporting ATPase 13A3 0.0009 0.0064 0.0052
Echinococcus multilocularis cation transporting ATPase 13A3 0.0009 0.0064 0.0052
Plasmodium falciparum heat shock protein 90 0.0052 0.0821 1
Plasmodium vivax heat shock protein 86, putative 0.0052 0.0821 1
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0005
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0351 0.0326
Plasmodium falciparum DNA topoisomerase VI, b subunit, putative 0.0027 0.0383 0.4211
Treponema pallidum chemotaxis histidine kinase (cheA) 0.0027 0.0383 1
Loa Loa (eye worm) DIX domain-containing protein 0.0009 0.0072 0.0069
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0009 0.0072 0.0062
Echinococcus multilocularis heat shock protein 90 0.0025 0.0351 0.0444
Giardia lamblia Heat shock protein HSP 90-alpha 0.0052 0.0821 1
Loa Loa (eye worm) glutaminase 0.0578 1 1
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.0375 0.6462 0.8794
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0026 0.0023
Trichomonas vaginalis heat shock protein, putative 0.0025 0.0351 0.0326
Echinococcus multilocularis heat shock protein 90 0.0052 0.0821 0.1086
Schistosoma mansoni endoplasmin 0.0052 0.0821 0.0818
Leishmania major heat shock protein 83-1 0.0052 0.0821 0.1183
Trichomonas vaginalis DNA helicase recq, putative 0.0025 0.0343 0.0317
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0072 0.0062
Mycobacterium ulcerans two component sensor histidine kinase SenX3 0.0027 0.0383 0.0321
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0009 0.0064 0.0784
Trypanosoma brucei Heat shock protein 83, putative 0.0052 0.0821 0.1183
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0026 0.0322
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0129 0.2163 0.3344
Trypanosoma cruzi heat shock protein 90, putative 0.0039 0.0596 0.0917
Loa Loa (eye worm) hypothetical protein 0.0009 0.0064 0.0061
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0031 0.0005
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.009 0.0331
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0186 0.016
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0186 0.0183
Trichomonas vaginalis heat shock protein, putative 0.0013 0.0138 0.0112
Loa Loa (eye worm) ICD-1 protein 0.0036 0.0539 0.0536
Echinococcus granulosus segment polarity protein dishevelled 0.0009 0.0072 0.0062
Echinococcus granulosus regulator of G protein signaling 7 0.0009 0.0072 0.0062
Toxoplasma gondii cation-transporting atpase family protein 0.0009 0.0064 0.0232
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.001 0.009 0.0088
Schistosoma mansoni cpg binding protein 0.0032 0.0465 0.0461
Loa Loa (eye worm) hypothetical protein 0.0009 0.0072 0.0069
Loa Loa (eye worm) Na,K-ATPase alpha subunit 0.0009 0.0064 0.0061
Echinococcus multilocularis geminin 0.0191 0.3245 0.4398
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0064 0.0052
Echinococcus granulosus heat shock protein 90 0.0025 0.0351 0.0444
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0253 0.0249
Echinococcus multilocularis transcription factor btf3 0.0036 0.0539 0.0701
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0026 0.0322
Trypanosoma brucei heat shock protein 90, putative 0.0052 0.0821 0.1183
Echinococcus multilocularis cation transporting ATPase 13A1 0.0009 0.0064 0.0052
Toxoplasma gondii Hsp90 domain-containing protein 0.0013 0.0138 0.0513
Brugia malayi potential phospholipid-transporting ATPase IIB, putative 0.0009 0.0064 0.0038
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0064 0.0052
Loa Loa (eye worm) hypothetical protein 0.0185 0.3147 0.3145
Leishmania major heat shock protein 83-1 0.0052 0.0821 0.1183
Loa Loa (eye worm) hypothetical protein 0.0016 0.0186 0.0183
Schistosoma mansoni cation-transporting atpase 13a1 (G-box binding protein) 0.0009 0.0064 0.0061
Schistosoma mansoni hypothetical protein 0.0034 0.0503 0.05
Entamoeba histolytica DNA topoisomerase II, putative 0.0027 0.0383 0.4664
Schistosoma mansoni hypothetical protein 0.0191 0.3245 0.3243
Brugia malayi E1-E2 ATPase family protein 0.0009 0.0064 0.0038
Trypanosoma cruzi hypothetical protein 0.0007 0.0026 0.0036
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative 0.0009 0.0064 0.0784
Echinococcus granulosus Pleckstrin G protein interacting region 0.0009 0.0072 0.0062
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0026 0.0322
Brugia malayi regulator of G-protein signaling egl-10 0.0009 0.0072 0.0046
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0064 0.0038
Trypanosoma brucei heat shock protein 90, putative 0.0052 0.0821 0.1183
Brugia malayi Endoplasmin precursor 0.0052 0.0821 0.0797
Giardia lamblia Sgs1 DNA helicase, putative 0.001 0.009 0.0345
Trypanosoma brucei heat shock protein, putative 0.0052 0.0821 0.1183
Trypanosoma cruzi P-type H+-ATPase, putative 0.0009 0.0064 0.0094
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0005
Brugia malayi hypothetical protein 0.0009 0.0072 0.0046
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0013 0.0138 0.0153
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein 0.0009 0.0064 0.0232
Leishmania major heat shock protein 83-1 0.0052 0.0821 0.1183
Trypanosoma brucei DNA topoisomerase II beta, putative 0.0027 0.0383 0.0498
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0026 0.0322
Trypanosoma cruzi P-type H+-ATPase, putative 0.0009 0.0064 0.0094
Echinococcus multilocularis phospholipid transporting ATPase IIB 0.0009 0.0064 0.0052
Brugia malayi CXXC zinc finger family protein 0.003 0.0435 0.0409
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0025 0.0351 0.0448
Leishmania major heat shock protein 83-1 0.0052 0.0821 0.1183
Schistosoma mansoni type V p-type atpase isoform 0.0009 0.0064 0.0061
Plasmodium vivax heat shock protein 90, putative 0.0013 0.0138 0.1686
Loa Loa (eye worm) hypothetical protein 0.0007 0.0026 0.0023
Schistosoma mansoni copper ABC transporter ATPase 0.0009 0.0064 0.0061
Leishmania major heat shock protein 83-1 0.0052 0.0821 0.1183
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0503 0.0478
Leishmania major heat shock protein 83-1 0.0052 0.0821 0.1183
Schistosoma mansoni heat shock protein 0.0052 0.0821 0.0818
Brugia malayi Sodium/potassium-transporting ATPase alpha chain, putative 0.0009 0.0064 0.0038
Toxoplasma gondii P-type ATPase PMA1 0.0009 0.0064 0.0232
Schistosoma mansoni endoplasmin 0.0052 0.0821 0.0818
Mycobacterium ulcerans two component sensor kinase MprB 0.0027 0.0383 0.0321
Loa Loa (eye worm) hypothetical protein 0.0124 0.2078 0.2075
Echinococcus granulosus DNA topoisomerase 2 alpha 0.0027 0.0383 0.0487
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0539 0.083
Toxoplasma gondii heavy metal translocating P-type ATPase subfamily protein 0.0009 0.0064 0.0232
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0007 0.0043 0.0022
Echinococcus multilocularis calcium transporting ATPase type 2C member 0.0009 0.0064 0.0052
Plasmodium falciparum endoplasmin, putative 0.004 0.0609 0.7189
Plasmodium vivax P-type ATPase4, putative 0.0009 0.0064 0.0784
Echinococcus multilocularis sarco:endoplasmic reticulum calcium ATPase 0.0009 0.0064 0.0052
Schistosoma mansoni camp-dependent rap1 guanine-nucleotide exchange factor 0.0006 0.0021 0.0017
Brugia malayi hypothetical protein 0.0009 0.0064 0.0038
Loa Loa (eye worm) heat shock protein 75 0.0013 0.0138 0.0135
Trypanosoma cruzi heat shock protein, putative 0.0013 0.0138 0.0209
Entamoeba histolytica heat shock protein 90, putative 0.0052 0.0821 1
Schistosoma mansoni Na+/K+ transporting ATPase subunit alpha 0.0009 0.0064 0.0061
Leishmania major heat shock protein 83-1 0.0052 0.0821 0.1183
Mycobacterium leprae PUTATIVE TWO COMPONENT SENSOR HISTIDINE KINASE SENX3 0.0027 0.0383 1
Echinococcus granulosus heat shock protein 90 0.0052 0.0821 0.1086
Toxoplasma gondii NAC domain-containing protein 0.0036 0.0539 0.2037
Loa Loa (eye worm) hypothetical protein 0.0027 0.0383 0.038
Schistosoma mansoni heat shock protein 0.0052 0.0821 0.0818
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 0.0009 0.0064 0.0052
Trypanosoma cruzi heat shock protein 90, putative 0.0052 0.0821 0.1266
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0539 0.0514
Onchocerca volvulus 0.0009 0.0072 0.0146
Mycobacterium tuberculosis Two component sensor histidine kinase DevS 0.0027 0.0383 1
Loa Loa (eye worm) hypothetical protein 0.0049 0.0776 0.0773
Trypanosoma brucei heat shock protein, putative 0.0052 0.0821 0.1183
Brugia malayi beta-NAC-like protein 0.0036 0.0539 0.0514
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0129 0.2163 0.3281
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0009 0.0072 0.0146
Loa Loa (eye worm) TOPoisomerase family member 0.0027 0.0383 0.038
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0383 0.4664
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0013 0.0138 0.0153
Mycobacterium ulcerans two component system response phosphate sensor kinase, PhoR 0.0027 0.0383 0.0321
Trypanosoma cruzi hypothetical protein 0.0007 0.0026 0.0036
Toxoplasma gondii phospholipid-translocating P-type ATPase, flippase subfamily protein 0.0009 0.0064 0.0232
Trypanosoma brucei heat shock protein 84, putative 0.0013 0.0138 0.0116
Echinococcus multilocularis segment polarity protein dishevelled 0.0009 0.0072 0.0062
Leishmania major heat shock protein, putative 0.0013 0.0138 0.0116
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0072 0.0046
Trichomonas vaginalis sensor histidine kinase, putative 0.0027 0.0383 0.0358
Giardia lamblia Grp94/Hsp90 0.0025 0.0351 0.3789
Schistosoma mansoni cpg binding protein 0.003 0.0435 0.0431
Echinococcus granulosus sarco:endoplasmic reticulum calcium ATPase 0.0009 0.0064 0.0052
Trypanosoma cruzi guanine nucleotide releasing protein, putative 0.0007 0.0026 0.0036
Echinococcus granulosus bloom syndrome protein 0.0025 0.0343 0.0433
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0064 0.0052
Loa Loa (eye worm) hypothetical protein 0.001 0.009 0.0087
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0009 0.0064 0.0784
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0186 0.0218
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0013 0.0138 0.0359
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL 0.0009 0.0064 0.0052
Loa Loa (eye worm) hypothetical protein 0.0009 0.0064 0.0061
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0031 0.0005
Trichomonas vaginalis DNA topoisomerase II, putative 0.0027 0.0383 0.0358
Giardia lamblia Heat shock protein HSP 90-alpha 0.0025 0.0351 0.3789
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0812 0.1074
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.02 0.0748
Echinococcus granulosus calcium transporting ATPase type 2C member 0.0009 0.0064 0.0052
Trypanosoma brucei heat shock protein, putative 0.0052 0.0821 0.1183
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0821 0.0797
Echinococcus granulosus copper transporting ATPase 1 0.0009 0.0064 0.0052
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.0375 0.6462 1
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0027 0.0383 0.0358
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0064 0.0052
Echinococcus granulosus dnaJ subfamily B 0.0426 0.7345 1
Plasmodium vivax DNA gyrase subunit B, putative 0.0027 0.0383 0.4664
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0435 0.0431
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0186 0.0218
Trypanosoma cruzi Heat shock protein 83, putative 0.0052 0.0821 0.1266
Trichomonas vaginalis heat shock protein, putative 0.004 0.0609 0.0584
Plasmodium falciparum basic transcription factor 3b, putative 0.0036 0.0539 0.6274
Trichomonas vaginalis glutaminase, putative 0.0578 1 1
Mycobacterium ulcerans two component system membrane associated sensor kinase 0.0027 0.0383 0.0321
Entamoeba histolytica transcription factor BTF3, putative 0.0036 0.0539 0.6566
Chlamydia trachomatis DNA gyrase subunit B 0.0027 0.0383 1
Chlamydia trachomatis DNA gyrase subunit B 0.0027 0.0383 1
Trichomonas vaginalis ATPase, class I, type 8B, putative 0.0009 0.0064 0.0038
Entamoeba histolytica hypothetical protein 0.0036 0.0539 0.6566
Trichomonas vaginalis DNA helicase recq1, putative 0.0025 0.0343 0.0317
Schistosoma mansoni transcription factor btf3 0.0036 0.0539 0.0536
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0009 0.0064 0.0094
Loa Loa (eye worm) ATP-dependent DNA helicase 0.001 0.009 0.0087
Echinococcus granulosus heat shock protein 0.0052 0.0821 0.1086
Plasmodium vivax heat shock protein, putative 0.0013 0.0138 0.1686
Onchocerca volvulus Putative DNA topoisomerase 2, mitochondrial 0.0027 0.0383 0.1143
Leishmania major heat shock protein 83-1 0.0052 0.0821 0.1183
Trypanosoma cruzi heat shock protein 85, putative 0.0052 0.0821 0.1266
Wolbachia endosymbiont of Brugia malayi membrane associated signal transduction histidine kinase 0.0027 0.0383 1
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0074 0.0066
Trypanosoma cruzi phospholipid-transporting ATPase-like protein, putative 0.0009 0.0064 0.0094
Echinococcus granulosus geminin 0.0191 0.3245 0.4398
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0539 0.0514
Onchocerca volvulus 0.0009 0.0064 0.0122
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0026 0.0322
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0143 0.0216
Trypanosoma cruzi Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative 0.0027 0.0383 0.0588
Loa Loa (eye worm) heat shock protein 90 0.0052 0.0821 0.0818
Brugia malayi hypothetical protein 0.009 0.1492 0.1469
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0026 0.0322
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0812 0.0809
Schistosoma mansoni cation-transporting ATPase 0.0009 0.0064 0.0061
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0031 0.0005
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0064 0.0038
Plasmodium vivax cation transporting ATPase, putative 0.0009 0.0064 0.0784
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0009 0.0064 0.0232
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0007 0.0026 0.0023
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0375 0.6462 0.8794
Brugia malayi Probable DNA topoisomerase II 0.0027 0.0383 0.0358
Brugia malayi Probable cation-transporting ATPase C10C6.6 in chromosome IV 0.0009 0.0064 0.0038
Mycobacterium ulcerans heat shock protein 90 0.0025 0.0351 0.0289
Plasmodium vivax calcium-transporting ATPase, putative 0.0009 0.0064 0.0784
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative 0.0009 0.0064 0.0784
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0052 0.0812 0.1074
Trichomonas vaginalis ATPase, class VI, type 11C, putative 0.0009 0.0064 0.0038
Entamoeba histolytica phospholipid-transporting P-type ATPase, putative 0.0009 0.0064 0.0784
Trypanosoma cruzi heat shock protein 90, putative 0.0025 0.0351 0.0538
Trypanosoma cruzi DNA topoisomerase II, putative 0.0027 0.0383 0.0588
Echinococcus multilocularis copper transporting ATPase 1 0.0009 0.0064 0.0052
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0064 0.0038
Trichomonas vaginalis receptor histidine kinase, putative 0.0027 0.0383 0.0358
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0539 0.0514
Toxoplasma gondii histone lysine methyltransferase SET1 0.0057 0.0902 0.3415
Schistosoma mansoni hypothetical protein 0.0016 0.0186 0.0183
Trypanosoma cruzi heat shock protein 85, putative 0.0052 0.0821 0.1266
Echinococcus granulosus cation transporting atpase worm 0.0009 0.0064 0.0052
Trypanosoma cruzi heat shock protein 85, putative 0.0025 0.0351 0.0538
Schistosoma mansoni ras GTP exchange factor 0.0007 0.0026 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0005
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.001 0.009 0.0331
Loa Loa (eye worm) hypothetical protein 0.0009 0.0072 0.0069
Mycobacterium ulcerans putative regultory protein 0.0027 0.0383 0.0321
Mycobacterium ulcerans glutaminase 0.0578 1 1
Schistosoma mansoni pyruvate dehydrogenase 0.0375 0.6462 0.6461
Trypanosoma brucei heat shock protein, putative 0.0052 0.0821 0.1183
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0026 0.0023
Echinococcus multilocularis cpg binding protein 0.0032 0.0465 0.0599
Trypanosoma brucei transcription factor BTF3, putative 0.0036 0.0539 0.0742
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0026 0.0322
Leishmania major developmentally regulated phosphoprotein-like protein 0.0375 0.6462 1
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0027 0.0383 0.1143
Echinococcus multilocularis bloom syndrome protein 0.0025 0.0343 0.0433
Schistosoma mansoni hypothetical protein 0.0016 0.0186 0.0183
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0064 0.0038
Trypanosoma brucei DNA topoisomerase II alpha, putative 0.0027 0.0383 0.0498
Trypanosoma brucei heat shock protein, putative 0.0052 0.0821 0.1183
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0063 0.102 0.1017
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0064 0.0038
Mycobacterium tuberculosis Conserved protein 0.0027 0.0383 1
Echinococcus multilocularis heat shock protein 0.0052 0.0821 0.1086
Trypanosoma cruzi heat shock protein 85, putative 0.0052 0.0821 0.1266
Loa Loa (eye worm) calcium ATPase 0.0009 0.0064 0.0061
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0064 0.0038
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0025 0.0351 0.8999
Mycobacterium leprae Probable two-component sensor kinase 0.0027 0.0383 1
Wolbachia endosymbiont of Brugia malayi signal transduction histidine kinase and receiver 0.0027 0.0383 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0009 0.0072 0.0069
Mycobacterium tuberculosis Two component sensor histidine kinase DosT 0.0027 0.0383 1
Schistosoma mansoni heat shock protein 0.0013 0.0138 0.0135
Brugia malayi hypothetical protein 0.0009 0.0072 0.0046
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0776 0.0752
Trypanosoma cruzi proton motive ATPase 1, putative 0.0009 0.0064 0.0094
Schistosoma mansoni dep domain containing protein 0.0009 0.0072 0.0069
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0007 0.0026 0.0023
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.001 0.009 0.0088
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative 0.0009 0.0064 0.0038
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0031 0.0005
Trypanosoma cruzi plasma membrane Ca2+ ATPase 0.0009 0.0064 0.0094
Loa Loa (eye worm) endoplasmin 0.0052 0.0821 0.0818
Schistosoma mansoni dishevelled 0.0009 0.0072 0.0069
Entamoeba histolytica calcium-transporting P-type ATPase, putative 0.0009 0.0064 0.0784
Schistosoma mansoni hypothetical protein 0.0016 0.0186 0.0183
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0031 0.0005
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0007 0.0031 0.0005
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0143 0.0122
Plasmodium vivax DNA topoisomerase II, putative 0.0027 0.0383 0.4664
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0013 0.0138 0.1686
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0026 0.0322
Loa Loa (eye worm) hypothetical protein 0.0009 0.0064 0.0061
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0005
Leishmania major basic transcription factor 3a, putative 0.0036 0.0539 0.0742
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0052 0.0812 0.1074
Echinococcus multilocularis cation transporting atpase worm 0.0009 0.0064 0.0052
Toxoplasma gondii hypothetical protein 0.0009 0.0072 0.0261
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0156 0.2633 1
Mycobacterium tuberculosis Possible two component system response sensor kinase membrane associated PhoR 0.0027 0.0383 1
Schistosoma mansoni DNA helicase recq5 0.001 0.009 0.0087
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0186 0.016
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.0027 0.0383 0.1444
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0005
Entamoeba histolytica heat shock protein 90, putative 0.0052 0.0821 1
Leishmania major heat shock protein 83-1 0.0052 0.0821 0.1183
Plasmodium vivax copper-transporting ATPase, putative 0.0009 0.0064 0.0784
Echinococcus granulosus transcription factor btf3 0.0036 0.0539 0.0701
Leishmania major heat shock protein 83-1 0.0052 0.0821 0.1183
Leishmania major heat shock protein 83-1 0.0052 0.0821 0.1183
Entamoeba histolytica cation-transporting P-typeATPase, putative 0.0009 0.0064 0.0784
Echinococcus granulosus GPCR family 2 0.0016 0.0186 0.0218
Schistosoma mansoni ATPase 0.0009 0.0064 0.0061
Trichomonas vaginalis mismatch repair protein Mlh1C (mutL homolog) 0.0027 0.0383 0.0358
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0027 0.0383 0.0588
Trypanosoma cruzi copper-transporting ATPase-like protein, putative 0.0009 0.0064 0.0094
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0186 0.0218
Trypanosoma cruzi mitochondrial DNA topoisomerase II, putative 0.0027 0.0383 0.0588
Brugia malayi kinase, mitochondrial precursor 0.0375 0.6462 0.6453
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0052 0.0812 0.0809
Trichomonas vaginalis cation-transporting ATPase, putative 0.0009 0.0064 0.0038
Mycobacterium tuberculosis Possible two component sensor kinase 0.0027 0.0383 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0007 0.0043 0.0022
Brugia malayi heat shock protein 90 0.0052 0.0821 0.0797
Echinococcus multilocularis DNA topoisomerase 2 alpha 0.0027 0.0383 0.0487
Echinococcus multilocularis phosphoserine phosphatase 0.0009 0.0064 0.0052
Toxoplasma gondii sarco/endoplasmic reticulum Ca2+-ATPase 0.0009 0.0064 0.0232
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0129 0.2163 0.8212
Wolbachia endosymbiont of Brugia malayi DNA gyrase, topoisomerase II, B subunit, GyrB 0.0027 0.0383 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0503 0.05
Mycobacterium ulcerans DNA gyrase subunit B 0.0027 0.0383 0.0321
Schistosoma mansoni eyes absent homolog 0.009 0.1492 0.1489
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.001 0.009 0.0345
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0007 0.0043 0.0039
Brugia malayi DNA topoisomerase II, alpha isozyme 0.0027 0.0383 0.0358
Trypanosoma cruzi cation-transporting ATPase, putative 0.0009 0.0064 0.0094
Echinococcus granulosus cation transporting ATPase 13A1 0.0009 0.0064 0.0052
Mycobacterium tuberculosis Two component sensor histidine kinase PrrB 0.0027 0.0383 1
Trichomonas vaginalis endoplasmin, putative 0.004 0.0609 0.0584
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0776 0.0773
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0007 0.0043 0.0022
Mycobacterium ulcerans sensor kinase from two component regulatory system 0.0027 0.0383 0.0321
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0204 0.2481
Mycobacterium ulcerans two component sensor histidine kinase TrcS 0.0027 0.0383 0.0321
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0812 0.0809
Echinococcus granulosus phospholipid transporting ATPase IIB 0.0009 0.0064 0.0052
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0013 0.0143 0.0122
Echinococcus granulosus ATP dependent DNA helicase Q5 0.001 0.009 0.0088
Schistosoma mansoni cation-transporting atpase worm 0.0009 0.0064 0.0061
Treponema pallidum DNA gyrase, subunit B (gyrB) 0.0027 0.0383 1
Schistosoma mansoni atpase class VI type 11c 0.0009 0.0064 0.0061
Entamoeba histolytica Ras guanine nucleotide exchange factor, putative 0.0007 0.0026 0.0322
Schistosoma mansoni ATPase 0.0009 0.0064 0.0061
Mycobacterium tuberculosis DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) 0.0027 0.0383 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0031 0.0005
Mycobacterium tuberculosis Two component sensor kinase [second part] 0.0027 0.0383 1
Schistosoma mansoni DNA helicase recq1 0.001 0.009 0.0087
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.0291 0.2991
Treponema pallidum cation-transporting ATPase, P-type 0.0009 0.0064 0.1605
Schistosoma mansoni dishevelled 0.0009 0.0072 0.0069
Trichomonas vaginalis phospholipid-transporting ATPase, putative 0.0009 0.0064 0.0038
Schistosoma mansoni z-protein (S1r protein) 0.0009 0.0072 0.0069
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0009 0.0064 0.0784
Plasmodium falciparum DNA gyrase subunit B 0.0027 0.0383 0.4211
Schistosoma mansoni hypothetical protein 0.0191 0.3245 0.3243
Brugia malayi DNA gyrase/topoisomerase IV, A subunit family protein 0.0027 0.0383 0.0358
Schistosoma mansoni pyruvate dehydrogenase 0.0348 0.5992 0.5991
Leishmania major heat shock protein 83-1 0.0052 0.0821 0.1183
Mycobacterium tuberculosis Two component sensor kinase MprB 0.0027 0.0383 1
Brugia malayi Na,K-ATPase alpha subunit 0.0009 0.0064 0.0038
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0052 0.0812 0.0809
Onchocerca volvulus DNA topoisomerase 2 homolog 0.0027 0.0383 0.1143
Leishmania major DNA topoisomerase ii 0.0027 0.0383 0.0498
Leishmania major mitochondrial DNA topoisomerase II 0.0027 0.0383 0.0498
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0143 0.0117
Schistosoma mansoni glutaminase 0.0578 1 1
Trichomonas vaginalis cation-transporting ATPase fungi, putative 0.0009 0.0064 0.0038
Mycobacterium tuberculosis Probable sensor protein KdpD 0.0027 0.0383 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0383 0.038
Leishmania major heat shock protein 83-1 0.0052 0.0821 0.1183
Loa Loa (eye worm) histone methyltransferase 0.0009 0.0074 0.0071
Trypanosoma brucei developmentally regulated phosphoprotein 0.0375 0.6462 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0007 0.0031 0.0005
Schistosoma mansoni hypothetical protein 0.0426 0.7345 0.7344
Toxoplasma gondii haloacid dehalogenase family hydrolase domain-containing protein 0.0009 0.0064 0.0232
Mycobacterium tuberculosis Possible two component sensor kinase TcrY 0.0027 0.0383 1
Trichomonas vaginalis two component sensor and regulator histidine kinase bacteria, putative 0.0027 0.0383 0.0358
Trypanosoma brucei heat shock protein, putative 0.0052 0.0821 0.1183
Loa Loa (eye worm) E1-E2 ATPase 0.0009 0.0064 0.0061
Loa Loa (eye worm) hypothetical protein 0.0009 0.0064 0.0061
Entamoeba histolytica hypothetical protein 0.0007 0.0026 0.0322
Echinococcus multilocularis regulator of G protein signaling 7 0.0009 0.0072 0.0062
Mycobacterium tuberculosis Probable two component sensor kinase 0.0027 0.0383 1
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0009 0.0072 0.0046
Leishmania major hypothetical protein, conserved 0.0027 0.0383 0.0498
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.009 0.0064
Brugia malayi E1-E2 ATPase family protein 0.0009 0.0064 0.0038
Treponema pallidum heat shock protein 90 0.0025 0.0351 0.916
Mycobacterium tuberculosis Two component sensor histidine kinase TrcS 0.0027 0.0383 1
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.0375 0.6462 0.8794
Trypanosoma cruzi copper-transporting ATPase, putative 0.0009 0.0064 0.0094
Brugia malayi N-terminal motif family protein 0.0185 0.3147 0.3129
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative 0.0009 0.0064 0.0784
Toxoplasma gondii heat shock protein 90, putative 0.0052 0.0821 0.311
Trypanosoma cruzi transcription factor btf3, putative 0.0036 0.0539 0.083
Trichomonas vaginalis conserved hypothetical protein 0.0007 0.0031 0.0005
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0052 0.0812 0.0788
Loa Loa (eye worm) RasGEF domain-containing protein 0.0007 0.0026 0.0023
Trichomonas vaginalis sensory transduction histidine kinase, putative 0.0027 0.0383 0.0358
Brugia malayi haloacid dehalogenase-like hydrolase family protein 0.0009 0.0064 0.0038
Onchocerca volvulus 0.003 0.0435 0.1308
Schistosoma mansoni hypothetical protein 0.0016 0.0186 0.0183
Trypanosoma brucei DNA topoisomerase ii 0.0027 0.0383 0.0498
Chlamydia trachomatis two component regulatory system sensor histidine kinase 0.0027 0.0383 1
Trichomonas vaginalis sensory transduction histidine kinase bacterial, putative 0.0027 0.0383 0.0358
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.001 0.009 0.0064

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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