Detailed information for compound 1796648

Basic information

Technical information
  • TDR Targets ID: 1796648
  • Name: N,N-dimethylbutan-1-amine
  • MW: 101.19 | Formula: C6H15N
  • H donors: 0 H acceptors: 0 LogP: 1.51 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN(C)C
  • InChi: 1S/C6H15N/c1-4-5-6-7(2)3/h4-6H2,1-3H3
  • InChiKey: DJEQZVQFEPKLOY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • butyl-dimethyl-amine
  • Butylamine, N,N-dimethyl-
  • 1-Butanamine, N,N-dimethyl-
  • AR 84996
  • Butylamine, N,N-dimethyl- (6CI,7CI,8CI)
  • Butyldimethylamine
  • Dimethylbutylamine
  • EINECS 213-156-1
  • N,N-DIMETHYL-N-BUTYLAMINE
  • N,N-Dimethyl-1-butanamine
  • N,N-Dimethylbutylamine
  • 39852_FLUKA
  • 369527_ALDRICH
  • N-Butyldimethylamine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0048 0.1489
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0004 0.0017
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0022 0.0069
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0079 0.0068 0.0245
Mycobacterium leprae conserved hypothetical protein 0.0079 0.0068 0.0177
Loa Loa (eye worm) acetyltransferase 0.0143 0.0134 0.2057
Brugia malayi MH1 domain containing protein 0.0019 0.0005 0.0021
Entamoeba histolytica hypothetical protein 0.0075 0.0063 0.7012
Leishmania major phosphatidylinositol 3-kinase, putative 0.0018 0.0004 0.0114
Schistosoma mansoni serine/threonine protein kinase 0.0049 0.0037 0.0136
Brugia malayi follicle stimulating hormone receptor 0.0229 0.0224 0.0866
Trypanosoma cruzi target of rapamycin kinase 3 0.0018 0.0004 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Trichomonas vaginalis glutaminase, putative 0.0547 0.0555 0.2145
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0625 0.0637 0.2459
Mycobacterium tuberculosis Probable lipase LipE 0.0079 0.0068 0.0245
Entamoeba histolytica hypothetical protein 0.0075 0.0063 0.7012
Mycobacterium leprae Conserved hypothetical protein 0.25 0.2589 1
Brugia malayi MH1 domain containing protein 0.0019 0.0005 0.0021
Trichomonas vaginalis inositol monophosphatase, putative 0.004 0.0027 0.0103
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0013 0.0048
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.0134 0.0512
Brugia malayi MH2 domain containing protein 0.0508 0.0514 0.1986
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0031 0.003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Toxoplasma gondii ABC1 family protein 0.0079 0.0068 0.3029
Mycobacterium ulcerans hypothetical protein 0.25 0.2589 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0004 0.0014
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0079 0.0068 0.0245
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0243 0.0239 0.0916
Echinococcus granulosus mitogen activated protein kinase 3 0.0049 0.0037 0.0136
Mycobacterium tuberculosis Conserved hypothetical protein 0.0159 0.0151 0.0567
Loa Loa (eye worm) glutaminase 0.0547 0.0555 0.8531
Loa Loa (eye worm) inositol-1 0.004 0.0027 0.0409
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0027 0.0879
Echinococcus multilocularis snurportin 1 0.0639 0.0651 0.0649
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0027 0.0879
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0079 0.0068 0.0245
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0013 0.0048
Mycobacterium tuberculosis Conserved protein 0.0079 0.0068 0.0245
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0049 0.0037 0.122
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0007 0.0225
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0039 0.1304
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0035 0.0022 0.0021
Schistosoma mansoni smad1 5 8 and 0.0035 0.0022 0.0077
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0068 0.2253
Onchocerca volvulus 0.0079 0.0068 0.0104
Onchocerca volvulus 0.0108 0.0098 0.015
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0013 0.0048
Loa Loa (eye worm) hypothetical protein 0.0079 0.0068 0.1041
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0028 0.0015 0.0052
Onchocerca volvulus Heat shock factor protein 2 homolog 0.0099 0.0089 0.0137
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0068 0.0262
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0068 0.0256
Loa Loa (eye worm) hypothetical protein 0.006 0.0048 0.0734
Schistosoma mansoni cpg binding protein 0.0121 0.0112 0.0425
Entamoeba histolytica acetyltransferase, GNAT family 0.0038 0.0026 0.2564
Plasmodium falciparum histone acetyltransferase GCN5 0.0038 0.0026 0.4851
Mycobacterium ulcerans hypothetical protein 0.25 0.2589 1
Entamoeba histolytica Ran family GTPase 0.0044 0.0031 0.3252
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0028 0.0015 0.0014
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0004 0.0068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0036 0.0139
Trypanosoma brucei hypothetical protein, conserved 0.0079 0.0068 0.2163
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.0029 0.1202
Echinococcus granulosus mothers against decapentaplegic 5 0.0035 0.0022 0.0077
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0037 0.0142
Echinococcus granulosus survival motor neuron protein 1 0.0528 0.0535 0.2062
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0018 0.0004 0.0008
Loa Loa (eye worm) MH2 domain-containing protein 0.0035 0.0022 0.033
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0013 0.0048
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0079 0.0068 0.0262
Loa Loa (eye worm) hypoxia-induced factor 1 0.0164 0.0156 0.24
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.0029 0.3895
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0229 0.0224 0.3446
Onchocerca volvulus 0.6142 0.6383 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0028 0.0015 0.0052
Schistosoma mansoni hypothetical protein 0.0198 0.0192 0.0734
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.004 0.0027 0.1084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Echinococcus multilocularis smad 0.0035 0.0022 0.002
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0063 0.0239
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0639 0.0651 1
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.0029 0.0113
Echinococcus granulosus smad 0.0035 0.0022 0.0077
Schistosoma mansoni inositol monophosphatase 0.004 0.0027 0.0097
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0018 0.0004 0.0116
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0198 0.0192 0.0734
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0004 0.0011
Echinococcus granulosus neuropeptide s receptor 0.1 0.1027 0.3963
Schistosoma mansoni smad1 5 8 and 0.0035 0.0022 0.0077
Brugia malayi beta-lactamase family protein 0.0079 0.0068 0.0262
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0108 0.0098 0.0377
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.03 1
Brugia malayi Thioredoxin family protein 0.25 0.2589 1
Loa Loa (eye worm) nuclear factor I 0.0019 0.0005 0.0082
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Brugia malayi Importin beta-1 subunit 0.006 0.0048 0.0185
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0024 0.0011 0.0035
Schistosoma mansoni hypothetical protein 0.0427 0.0431 0.1658
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0004 0.0017
Brugia malayi CXXC zinc finger family protein 0.0115 0.0105 0.0405
Echinococcus granulosus mitogen activated protein kinase 0.0049 0.0037 0.0136
Onchocerca volvulus Huntingtin homolog 0.041 0.0413 0.0645
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.003 0.0982
Trypanosoma cruzi hypothetical protein, conserved 0.0079 0.0068 0.2253
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0004 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0004 0.0114
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0037 0.122
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0004 0.014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0018 0.0004 0.0114
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0068 0.0262
Loa Loa (eye worm) phosphatidylinositol 3 0.0018 0.0004 0.0056
Brugia malayi glutaminase DH11.1 0.0547 0.0555 0.2145
Plasmodium vivax hypothetical protein, conserved 0.0079 0.0068 1
Loa Loa (eye worm) hypothetical protein 0.0099 0.0089 0.1362
Schistosoma mansoni lamin 0.0026 0.0013 0.0043
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0013 0.0048
Mycobacterium tuberculosis Probable esterase LipL 0.0079 0.0068 0.0245
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0004 0.0003
Brugia malayi MH1 domain containing protein 0.0035 0.0022 0.0083
Loa Loa (eye worm) hypothetical protein 0.0079 0.0068 0.1041
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Mycobacterium tuberculosis Probable hydrolase 0.0079 0.0068 0.0245
Onchocerca volvulus 0.0039 0.0026 0.0039
Plasmodium vivax importin-beta 2, putative 0.006 0.0048 0.6844
Echinococcus granulosus inositol monophosphatase 1 0.004 0.0027 0.0097
Schistosoma mansoni ran 0.0044 0.0031 0.0115
Loa Loa (eye worm) hypothetical protein 0.0625 0.0637 0.9781
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0198 0.0192 0.0734
Brugia malayi hypothetical protein 0.0075 0.0063 0.0244
Leishmania major importin beta-1 subunit, putative 0.0049 0.0036 0.1193
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0004 0.0026
Echinococcus multilocularis importin subunit beta 1 0.006 0.0048 0.0046
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0143 0.0134 0.4408
Mycobacterium leprae Probable lipase LipE 0.0079 0.0068 0.0177
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0013 0.0049
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0004 0.0003
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.004 0.0027 0.0086
Echinococcus granulosus single minded 2 0.0039 0.0026 0.0096
Loa Loa (eye worm) beta-lactamase 0.0079 0.0068 0.1041
Brugia malayi mothers against decapentaplegic homolog 3 0.0015 0.0002 0.0006
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0035 0.0022 0.002
Brugia malayi bHLH-PAS transcription factor 0.0039 0.0026 0.0101
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0018 0.0004 0.0002
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.0029 0.0113
Loa Loa (eye worm) hypothetical protein 0.0178 0.0171 0.262
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0031 0.1307
Brugia malayi MH1 domain containing protein 0.0035 0.0022 0.0083
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.003 0.0982
Loa Loa (eye worm) MH2 domain-containing protein 0.0015 0.0002 0.0024
Echinococcus granulosus beta LACTamase domain containing family member 0.0079 0.0068 0.0256
Mycobacterium tuberculosis Probable lipase LipD 0.0079 0.0068 0.0245
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0004 0.0091
Echinococcus multilocularis GPCR, family 2 0.0198 0.0192 0.019
Mycobacterium ulcerans lipase LipD 0.0079 0.0068 0.0245
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0013 0.0048
Echinococcus multilocularis microtubule associated protein 2 0.0668 0.0681 0.068
Echinococcus multilocularis mothers against decapentaplegic 5 0.0035 0.0022 0.002
Loa Loa (eye worm) hypothetical protein 0.0427 0.0431 0.6616
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0031 0.1037
Brugia malayi hypothetical protein 0.0528 0.0535 0.2067
Mycobacterium ulcerans hypothetical protein 0.0159 0.0151 0.0567
Echinococcus granulosus importin subunit beta 1 0.006 0.0048 0.0179
Onchocerca volvulus 0.0079 0.0068 0.0104
Schistosoma mansoni single-minded 0.0053 0.0041 0.0151
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0018 0.0004 0.0008
Brugia malayi HSF-type DNA-binding domain containing protein 0.0099 0.0089 0.0343
Loa Loa (eye worm) hypothetical protein 0.0198 0.0192 0.2942
Schistosoma mansoni glutaminase 0.0547 0.0555 0.214
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0031 0.4245
Trypanosoma brucei protein kinase, putative 0.0049 0.0037 0.1119
Schistosoma mansoni intermediate filament proteins 0.0026 0.0013 0.0043
Schistosoma mansoni hypothetical protein 0.0639 0.0651 0.251
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.0029 0.1202
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0027 0.0103
Schistosoma mansoni lamin 0.0026 0.0013 0.0043
Mycobacterium tuberculosis Conserved hypothetical protein 0.25 0.2589 1
Echinococcus multilocularis inositol monophosphatase 1 0.004 0.0027 0.0025
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0068 0.0262
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0035 0.0022 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0528 0.0535 0.8219
Brugia malayi Smad1 0.0035 0.0022 0.0083
Loa Loa (eye worm) transcription factor SMAD2 0.0508 0.0514 0.7899
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0011 0.0041
Echinococcus multilocularis musashi 0.0026 0.0013 0.0011
Entamoeba histolytica heat shock transcription factor, putative 0.0099 0.0089 1
Toxoplasma gondii exonuclease III APE 0.0018 0.0004 0.0036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.0185 0.0183
Brugia malayi hypoxia-induced factor 1 0.0164 0.0156 0.0603
Leishmania major hypothetical protein, conserved 0.0079 0.0068 0.2253
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0191 0.0185 0.2837
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0013 0.0048
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0198 0.0192 0.019
Echinococcus granulosus Smad4 0.0035 0.0022 0.0077
Toxoplasma gondii hypothetical protein 0.0049 0.0036 0.1536
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0079 0.0068 0.0245
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0027 0.0774
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0004 0.014
Onchocerca volvulus 0.0026 0.0013 0.0017
Trichomonas vaginalis D-aminoacylase, putative 0.0079 0.0068 0.0262
Mycobacterium ulcerans beta-lactamase 0.0079 0.0068 0.0245
Schistosoma mansoni smad 0.0035 0.0022 0.0077
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.013 0.0496
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.0185 0.0708
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0018 0.0004 0.0114
Echinococcus granulosus intermediate filament protein 0.0026 0.0013 0.0043
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.0185 0.0183
Entamoeba histolytica hypothetical protein 0.0024 0.0011 0.0801
Giardia lamblia Transglutaminase/protease, putative 0.25 0.2589 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Brugia malayi Latrophilin receptor protein 2 0.0198 0.0192 0.074
Schistosoma mansoni hypothetical protein 0.0198 0.0192 0.0734
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Leishmania major mitochondrial DNA polymerase beta 0.0302 0.03 1
Schistosoma mansoni hypothetical protein 0.25 0.2589 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.004 0.0027 0.0103
Brugia malayi intermediate filament protein 0.0026 0.0013 0.0049
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0018 0.0004 0.0014
Trichomonas vaginalis esterase, putative 0.0079 0.0068 0.0262
Leishmania major phosphatidylinositol kinase related protein, putative 0.0018 0.0004 0.0116
Loa Loa (eye worm) hypothetical protein 0.0079 0.0068 0.1041
Mycobacterium tuberculosis Long conserved protein 0.25 0.2589 1
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0048 0.1489
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Loa Loa (eye worm) hypothetical protein 0.0026 0.0012 0.0186
Schistosoma mansoni cpg binding protein 0.0121 0.0112 0.0425
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.0185 0.0708
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.003 0.0877
Mycobacterium tuberculosis Conserved protein 0.0079 0.0068 0.0245
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.0134 0.0132
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0013 0.0048
Echinococcus multilocularis Smad4 0.0035 0.0022 0.002
Brugia malayi MH2 domain containing protein 0.0015 0.0002 0.0006
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0013 0.0048
Brugia malayi Calcitonin receptor-like protein seb-1 0.0625 0.0637 0.2459
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0035 0.0022 0.0081
Echinococcus multilocularis lamin 0.0026 0.0013 0.0011
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0031 0.0115
Echinococcus granulosus serine protein kinase ATM 0.0024 0.0011 0.0035
Schistosoma mansoni ap endonuclease 0.0018 0.0004 0.0011
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0011 0.004
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0198 0.0192 0.019
Brugia malayi beta-lactamase 0.0079 0.0068 0.0262
Loa Loa (eye worm) hypothetical protein 0.0015 0.0002 0.0024
Echinococcus granulosus dnaJ subfamily B 0.1199 0.1234 0.4762
Leishmania major GTP-binding protein, putative 0.0044 0.0031 0.1037
Mycobacterium leprae Conserved hypothetical protein 0.25 0.2589 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0013 0.0194
Schistosoma mansoni microtubule-associated protein tau 0.0668 0.0681 0.2627
Loa Loa (eye worm) latrophilin receptor protein 2 0.0198 0.0192 0.2942
Brugia malayi latrophilin 2 splice variant baaae 0.0427 0.0431 0.1663
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.003 0.0982
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0049 0.0037 0.0565
Brugia malayi MH2 domain containing protein 0.0035 0.0022 0.0083
Loa Loa (eye worm) hypothetical protein 0.0079 0.0068 0.1041
Brugia malayi MAP kinase sur-1 0.0049 0.0037 0.0142
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0013 0.0048
Echinococcus granulosus microtubule associated protein 2 0.0668 0.0681 0.2627
Trichomonas vaginalis peptide N-glycanase, putative 0.25 0.2589 1
Loa Loa (eye worm) MH1 domain-containing protein 0.0035 0.0022 0.033
Schistosoma mansoni hypothetical protein 0.0198 0.0192 0.0734
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0063 0.0062
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0037 0.0142
Trichomonas vaginalis penicillin-binding protein, putative 0.0079 0.0068 0.0262
Mycobacterium ulcerans putative regulatory protein 0.0039 0.0026 0.0084
Echinococcus granulosus neuropeptide receptor A26 0.1 0.1027 0.3963
Brugia malayi RNA, U transporter 1 0.017 0.0163 0.0628
Loa Loa (eye worm) MH2 domain-containing protein 0.0508 0.0514 0.7899
Brugia malayi hypothetical protein 0.041 0.0413 0.1595
Echinococcus granulosus lamin 0.0026 0.0013 0.0043
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0018 0.0004 0.0114
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0013 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Schistosoma mansoni hypothetical protein 0.1199 0.1234 0.4762
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0079 0.0068 0.1041
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0134 0.4472
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0036 0.1193
Mycobacterium ulcerans putative transglutaminase-like protein 0.25 0.2589 1
Schistosoma mansoni hypothetical protein 0.0719 0.0735 0.2834
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0031 0.1037
Echinococcus granulosus mixed lineage leukemia protein mll 0.0028 0.0015 0.0052
Loa Loa (eye worm) MH1 domain-containing protein 0.0015 0.0002 0.0024
Echinococcus granulosus Transglutaminase 0.25 0.2589 1
Schistosoma mansoni aryl hydrocarbon receptor 0.0053 0.0041 0.0151
Mycobacterium ulcerans hypothetical protein 0.0079 0.0068 0.0245
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0037 0.0142
Brugia malayi Inositol-1 0.004 0.0027 0.0103
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0031 0.6202
Schistosoma mansoni hypothetical protein 0.0198 0.0192 0.0734
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Brugia malayi PAS domain containing protein 0.0053 0.0041 0.0157
Echinococcus multilocularis survival motor neuron protein 1 0.0528 0.0535 0.0534
Schistosoma mansoni cpg binding protein 0.0115 0.0105 0.0399
Echinococcus multilocularis mitogen activated protein kinase 3 0.0049 0.0037 0.0035
Mycobacterium ulcerans esterase/lipase LipP 0.0079 0.0068 0.0245
Trichomonas vaginalis helicase, putative 0.0026 0.0013 0.0048
Loa Loa (eye worm) glutaminase 2 0.0547 0.0555 0.8531
Loa Loa (eye worm) hypothetical protein 0.041 0.0413 0.6342
Echinococcus multilocularis geminin 0.0719 0.0735 0.0733
Entamoeba histolytica myo-inositol monophosphatase, putative 0.004 0.0027 0.2697
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.004 0.0027 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0013 0.0048
Loa Loa (eye worm) CXXC zinc finger family protein 0.0115 0.0105 0.161
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0013 0.0048
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Schistosoma mansoni Smad4 0.0035 0.0022 0.0077
Schistosoma mansoni importin beta-1 0.006 0.0048 0.0179
Schistosoma mansoni hypothetical protein 0.0719 0.0735 0.2834
Mycobacterium ulcerans glutaminase 0.0547 0.0555 0.2132
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.0029 0.0107
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0191 0.0185 0.0713
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0018 0.0004 0.0008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Entamoeba histolytica hypothetical protein 0.0075 0.0063 0.7012
Onchocerca volvulus Huntingtin homolog 0.041 0.0413 0.0645
Plasmodium falciparum importin beta, putative 0.006 0.0048 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0079 0.0068 0.0066
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0031 0.0107
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0026 0.0013 0.0048
Echinococcus granulosus snurportin 1 0.0639 0.0651 0.251
Entamoeba histolytica hypothetical protein 0.0075 0.0063 0.7012
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0024 0.0011 0.023
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0049 0.0037 0.1119
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0013 0.0194
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0024 0.0011 0.0342
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0031 0.0481
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0302 0.03 1
Loa Loa (eye worm) hypothetical protein 0.0079 0.0068 0.1041
Giardia lamblia Kinase, CMGC MAPK 0.0049 0.0037 0.0128
Toxoplasma gondii FATC domain-containing protein 0.0024 0.0011 0.0322
Schistosoma mansoni smad1 5 8 and 0.0035 0.0022 0.0077
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0198 0.0192 0.074
Echinococcus multilocularis neuropeptide receptor A26 0.1 0.1027 0.1025
Trichomonas vaginalis ran, putative 0.0044 0.0031 0.0121
Trichomonas vaginalis CMGC family protein kinase 0.0049 0.0037 0.0142
Echinococcus multilocularis serine protein kinase ATM 0.0024 0.0011 0.0009
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0018 0.0004 0.0114
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0031 0.0121
Onchocerca volvulus 0.0026 0.0013 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Schistosoma mansoni hypothetical protein 0.0108 0.0098 0.0371
Entamoeba histolytica heat shock transcription factor, putative 0.0099 0.0089 1
Echinococcus granulosus lamin dm0 0.0026 0.0013 0.0043
Echinococcus multilocularis dnaJ subfamily B 0.1199 0.1234 0.1232
Echinococcus multilocularis transfer RNA-Lys 0.0039 0.0026 0.0025
Entamoeba histolytica heat shock transcription factor, putative 0.0099 0.0089 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0063 0.0239
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0004 0.0017
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0625 0.0637 0.9781
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0302 0.03 1
Mycobacterium tuberculosis Conserved protein 0.0079 0.0068 0.0245
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.0185 0.0708
Loa Loa (eye worm) histone methyltransferase 0.0035 0.0022 0.0344
Echinococcus granulosus GPCR family 2 0.0198 0.0192 0.0734
Mycobacterium tuberculosis Conserved protein 0.25 0.2589 1
Schistosoma mansoni ran 0.0044 0.0031 0.0115
Giardia lamblia Histone acetyltransferase GCN5 0.0038 0.0026 0.0084
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0018 0.0004 0.0114
Echinococcus multilocularis Transglutaminase 0.25 0.2589 0.2588
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0036 0.0139
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0505 0.0511 0.1961
Giardia lamblia Hypothetical protein 0.25 0.2589 1
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.0134 0.0517
Loa Loa (eye worm) Smad1 0.0035 0.0022 0.033
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0018 0.0004 0.0008
Onchocerca volvulus 0.0079 0.0068 0.0104
Echinococcus multilocularis cpg binding protein 0.0121 0.0112 0.011
Schistosoma mansoni survival motor neuron protein 0.0108 0.0098 0.0371
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.0185 0.0708
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0018 0.0004 0.0114
Mycobacterium ulcerans transglutaminase family protein 0.25 0.2589 1
Onchocerca volvulus 0.0115 0.0105 0.0162
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0049 0.0037 0.1566
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0049 0.0037 0.122
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0079 0.0068 0.0256
Loa Loa (eye worm) hypothetical protein 0.0019 0.0005 0.0082
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0004 0.5
Toxoplasma gondii HEAT repeat-containing protein 0.006 0.0048 0.2085
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0013 0.0194
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0004 0.014
Loa Loa (eye worm) hypothetical protein 0.0021 0.0007 0.0107
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.0185 0.0708
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0028 0.0015 0.0014
Brugia malayi MH2 domain containing protein 0.0035 0.0022 0.0083
Schistosoma mansoni hypothetical protein 0.0075 0.0063 0.0239
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Echinococcus multilocularis mitogen activated protein kinase 0.0049 0.0037 0.0035
Echinococcus granulosus cpg binding protein 0.0121 0.0112 0.0425
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0049 0.0037 0.122
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0026 0.0013 0.0048
Entamoeba histolytica hypothetical protein 0.0049 0.0036 0.3801
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0016 0.0003 0.0004
Loa Loa (eye worm) hypothetical protein 0.041 0.0413 0.6342
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0018 0.0004 0.0114
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0049 0.0037 0.122
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0013 0.0048
Brugia malayi beta-lactamase family protein 0.0079 0.0068 0.0262
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0031 0.0933
Loa Loa (eye worm) hypothetical protein 0.0079 0.0068 0.1041
Schistosoma mansoni inositol monophosphatase 0.004 0.0027 0.0097
Mycobacterium tuberculosis Conserved hypothetical protein 0.25 0.2589 1
Echinococcus multilocularis lamin dm0 0.0026 0.0013 0.0011
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.004 0.0027 0.0879
Echinococcus granulosus TGF beta signal transducer SmadC 0.0035 0.0022 0.0077
Echinococcus granulosus geminin 0.0719 0.0735 0.2834
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0013 0.0048
Schistosoma mansoni ap endonuclease 0.0018 0.0004 0.0011
Toxoplasma gondii histone lysine methyltransferase SET1 0.0221 0.0215 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0004 0.0014
Brugia malayi hypothetical protein 0.0178 0.0171 0.0659
Echinococcus multilocularis neuropeptide s receptor 0.1 0.1027 0.1025
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0143 0.0134 0.4472
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0049 0.0037 0.122
Mycobacterium tuberculosis Hypothetical protein 0.25 0.2589 1
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0036 0.0139
Brugia malayi F/Y-rich N-terminus family protein 0.0035 0.0022 0.0085
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0018 0.0004 0.0002

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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