TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 345.394 | Formula: C21H19N3O2
H donors: 2 H acceptors: 2 LogP: 4.38 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Oc1ccc(cc1)C1N(NC(=O)c2c(N1C)cccc2)c1ccccc1
InChi: 1S/C21H19N3O2/c1-23-19-10-6-5-9-18(19)20(26)22-24(16-7-3-2-4-8-16)21(23)15-11-13-17(25)14-12-15/h2-14,21,25H,1H3,(H,22,26)
InChiKey: PUGVXQYWAJKSPE-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Leishmania major	proteasome alpha 7 subunit, putative	0.0021	0.0371	0.0436
Echinococcus granulosus	proteasome prosome macropain subunit alpha	0.0021	0.0371	0.0464
Brugia malayi	Proteasome A-type and B-type family protein	0.0021	0.0371	0.0371
Schistosoma mansoni	cytochrome P450	0.0012	0.0023	0.0029
Mycobacterium leprae	proteasome (beta subunit) PrcB	0.0218	0.7993	1
Trypanosoma cruzi	proteasome subunit alpha type-1, putative	0.0021	0.0371	0.0436
Toxoplasma gondii	proteasome subunit	0.0021	0.0371	0.0436
Loa Loa (eye worm)	hypothetical protein	0.0043	0.1213	0.1213
Leishmania major	cytochrome p450-like protein	0.0023	0.0419	0.0496
Brugia malayi	proteasome subunit beta type 3	0.0021	0.0371	0.0371
Plasmodium falciparum	proteasome subunit beta type-5	0.0218	0.7993	1
Mycobacterium leprae	probable proteasome (alpha subunit) PrcA	0.0021	0.0371	0.0436
Echinococcus granulosus	dual specificity protein kinase clk2	0.0071	0.2274	0.2845
Plasmodium falciparum	protein serine/threonine kinase-1	0.0071	0.2274	0.2496
Echinococcus multilocularis	Peptidase C19, ubiquitin carboxyl terminal hydrolase 2	0.0043	0.1213	0.1518
Schistosoma mansoni	hypothetical protein	0.0023	0.0434	0.0543
Schistosoma mansoni	proteasome subunit alpha 4 (T01 family)	0.0021	0.0371	0.0464
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0218	0.7993	1
Brugia malayi	Cytochrome P450 family protein	0.0023	0.0419	0.0419
Brugia malayi	20S proteasome alpha5 subunit	0.0021	0.0371	0.0371
Toxoplasma gondii	proteasome beta subunit	0.0021	0.0371	0.0436
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0021	0.0371	0.0464
Leishmania major	proteasome alpha 7 subunit, putative	0.0021	0.0371	0.0436
Trypanosoma brucei	cytochrome P450, putative	0.0023	0.0419	0.0496
Brugia malayi	Doublecortin family protein	0.0023	0.0434	0.0434
Echinococcus granulosus	lipoxygenase domain containing protein	0.0023	0.0434	0.0543
Leishmania major	proteasome alpha 1 subunit, putative	0.0021	0.0371	0.0436
Toxoplasma gondii	proteasome subunit beta type 2, putative	0.0021	0.0371	0.0436
Echinococcus granulosus	RUN	0.0023	0.0434	0.0543
Echinococcus multilocularis	proteasome (prosome macropain) subunit beta type	0.0021	0.0371	0.0464
Toxoplasma gondii	proteasome subunit alpha type 5-2, putative	0.0021	0.0371	0.0436
Echinococcus granulosus	Polycystic kidney disease protein	0.0023	0.0434	0.0543
Leishmania major	proteasome alpha 2 subunit, putative	0.0021	0.0371	0.0436
Trypanosoma brucei	proteasome beta-1 subunit, putative	0.0021	0.0371	0.0436
Schistosoma mansoni	serine/threonine protein kinase	0.0071	0.2274	0.2845
Echinococcus granulosus	hypothetical protein	0.007	0.2253	0.2818
Schistosoma mansoni	ubiquitin-specific peptidase 2 (C19 family)	0.0043	0.1213	0.1518
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0021	0.0371	0.0371
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0021	0.0371	0.0436
Toxoplasma gondii	heat shock protein hslv, putative	0.0021	0.0371	0.0436
Schistosoma mansoni	proteasome catalytic subunit 3 (T01 family)	0.0218	0.7993	1
Schistosoma mansoni	proteasome subunit beta 1 (T01 family)	0.0069	0.2194	0.2745
Mycobacterium tuberculosis	Proteasome beta subunit PrcB; assembles with alpha subunit PrcA.	0.0218	0.7993	1
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0218	0.7993	0.7993
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0021	0.0371	0.0436
Onchocerca volvulus		0.0023	0.0434	1
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0043	0.1213	0.1105
Echinococcus granulosus	proteasome subunit alpha type 2	0.0021	0.0371	0.0464
Brugia malayi	Ubiquitin carboxyl-terminal hydrolase family protein	0.0043	0.1213	0.1213
Echinococcus granulosus	proteasome subunit beta t family	0.0021	0.0371	0.0464
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0021	0.0371	0.0464
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0021	0.0371	0.0436
Onchocerca volvulus	Notchless protein homolog	0.0021	0.0371	0.8547
Trypanosoma brucei	proteasome alpha 7 subunit	0.0021	0.0371	0.0436
Echinococcus granulosus	arachidonate 5 lipoxygenase	0.0064	0.2036	0.2547
Echinococcus multilocularis	20S proteasome subunit alpha 6	0.0021	0.0371	0.0464
Brugia malayi	Proteasome A-type and B-type family protein	0.0021	0.0371	0.0371
Trypanosoma brucei	kinetoplastid kinetochore protein 19	0.0071	0.2274	0.2824
Echinococcus granulosus	proteasome subunit beta type 7	0.0021	0.0371	0.0464
Echinococcus granulosus	proteasome prosome macropain subunit beta type	0.0021	0.0371	0.0464
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0021	0.0371	0.0464
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0021	0.0371	0.0436
Schistosoma mansoni	proteasome subunit alpha 3 (T01 family)	0.0021	0.0371	0.0464
Schistosoma mansoni	polycystin 1-related	0.0023	0.0434	0.0543
Brugia malayi	Protein kinase domain containing protein	0.0071	0.2274	0.2274
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0021	0.0371	0.0464
Loa Loa (eye worm)	20S proteasome alpha5 subunit	0.0021	0.0371	0.0371
Plasmodium vivax	proteasome subunit beta type-1, putative	0.0069	0.2194	0.2392
Giardia lamblia	Ubiquitin carboxyl-terminal hydrolase 4	0.0043	0.1213	0.1105
Brugia malayi	proteasome subunit alpha type 3	0.0021	0.0371	0.0371
Loa Loa (eye worm)	proteasome subunit beta type 1	0.0069	0.2194	0.2194
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0021	0.0371	0.0464
Leishmania major	ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative	0.0043	0.1213	0.1493
Brugia malayi	Proteasome A-type and B-type family protein	0.0218	0.7993	0.7993
Schistosoma mansoni	proteasome subunit beta 4 (T01 family)	0.0021	0.0371	0.0464
Echinococcus granulosus	proteasome subunit beta type 6	0.0021	0.0371	0.0464
Echinococcus multilocularis		0.0012	0.0023	0.0029
Brugia malayi	proteasome subunit beta type 2	0.0021	0.0371	0.0371
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0021	0.0371	0.0436
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0069	0.2194	0.2745
Loa Loa (eye worm)	CMGC/CLK protein kinase	0.0071	0.2274	0.2274
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0021	0.0371	0.0464
Echinococcus multilocularis	RUN	0.0023	0.0434	0.0543
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0021	0.0371	0.0436
Trypanosoma cruzi	proteasome alpha 3 subunit, putative	0.0021	0.0371	0.0436
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0071	0.2274	0.2824
Leishmania major	proteasome beta 7 subunit, putative	0.0021	0.0371	0.0436
Entamoeba histolytica	ubiquitin carboxyl-terminal hydrolase domain containing protein	0.0043	0.1213	0.1105
Plasmodium falciparum	proteasome subunit beta type-1, putative	0.0069	0.2194	0.2392
Trypanosoma brucei	proteasome alpha 3 subunit, putative	0.0021	0.0371	0.0436
Loa Loa (eye worm)	cytochrome P450 family protein	0.0035	0.0884	0.0884
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0021	0.0371	0.0436
Echinococcus multilocularis	Proteasome, subunit alpha beta	0.0021	0.0371	0.0464
Trypanosoma cruzi	kinetoplastid kinetochore protein 10, putative	0.0071	0.2274	0.2824
Schistosoma mansoni	loxhd1	0.0023	0.0434	0.0543
Echinococcus granulosus	20S proteasome subunit alpha 6	0.0021	0.0371	0.0464
Giardia lamblia	Proteasome subunit beta type 5 precursor	0.0218	0.7993	1
Trichomonas vaginalis	CMGC family protein kinase	0.0071	0.2274	0.2496
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0071	0.2274	0.2824
Schistosoma mansoni	rab6-interacting	0.0023	0.0434	0.0543
Wolbachia endosymbiont of Brugia malayi	ATP-dependent protease peptidase subunit	0.0021	0.0371	0.5
Loa Loa (eye worm)	proteasome subunit alpha type 2	0.0021	0.0371	0.0371
Trypanosoma cruzi	proteasome alpha 2 subunit, putative	0.0021	0.0371	0.0436
Echinococcus multilocularis		0.007	0.2253	0.2818
Toxoplasma gondii	peptidase, T1 family protein	0.0021	0.0371	0.0436
Schistosoma mansoni	proteasome catalytic subunit 2 (T01 family)	0.0021	0.0371	0.0464
Trypanosoma brucei	proteasome subunit beta type-5, putative	0.0218	0.7993	1
Brugia malayi	proteasome subunit alpha type 4	0.0021	0.0371	0.0371
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0021	0.0371	0.0436
Leishmania major	protein kinase, putative	0.0071	0.2274	0.2824
Trypanosoma brucei	Proteasome subunit A N-terminal signature/Proteasome subunit, putative	0.0021	0.0371	0.0436
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0023	0.0434	0.0543
Trypanosoma cruzi	kinetoplastid kinetochore protein 19, putative	0.0071	0.2274	0.2824
Echinococcus granulosus	Proteasome subunit alpha type 7	0.0021	0.0371	0.0464
Schistosoma mansoni	serine/threonine protein kinase	0.0071	0.2274	0.2845
Leishmania major	proteasome beta 5 subunit, putative	0.0218	0.7993	1
Echinococcus multilocularis	ubiquitin carboxyl terminal hydrolase 8	0.0043	0.1213	0.1518
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0069	0.2194	0.2724
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0218	0.7993	1
Schistosoma mansoni	rab6-interacting	0.0023	0.0434	0.0543
Brugia malayi	Cytochrome P450 family protein	0.0023	0.0419	0.0419
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0043	0.1213	0.1493
Trypanosoma cruzi	ubiquitin carboxyl-terminal hydrolase, putative	0.0043	0.1213	0.1493
Trypanosoma cruzi	cytochrome P450, putative	0.0023	0.0419	0.0496
Trypanosoma cruzi	proteasome subunit beta type-2, putative	0.0021	0.0371	0.0436
Trypanosoma brucei	proteasome subunit alpha type-5, putative	0.0021	0.0371	0.0436
Brugia malayi	hypothetical protein	0.0023	0.0434	0.0434
Echinococcus multilocularis	proteasome (prosome, macropain)	0.0218	0.7993	1
Schistosoma mansoni	proteasome subunit beta 3 (T01 family)	0.0021	0.0371	0.0464
Leishmania major	proteasome beta 3 subunit, putative	0.0021	0.0371	0.0436
Trypanosoma cruzi	cytochrome P450, putative	0.0023	0.0419	0.0496
Mycobacterium tuberculosis	Proteasome alpha subunit PrcA; assembles with beta subunit PrcB.	0.0021	0.0371	0.0436
Echinococcus granulosus	lipoxygenase domain containing protein	0.0023	0.0434	0.0543
Schistosoma mansoni	proteasome subunit alpha 2 (T01 family)	0.0021	0.0371	0.0464
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0021	0.0371	0.0436
Mycobacterium ulcerans	proteasome PrcB	0.0218	0.7993	1
Echinococcus multilocularis	ubiquitin specific protease 41	0.0043	0.1213	0.1518
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0021	0.0371	0.0436
Loa Loa (eye worm)	proteasome subunit alpha type 3	0.0021	0.0371	0.0371
Trypanosoma brucei	proteasome beta 6 subunit	0.0069	0.2194	0.2724
Toxoplasma gondii	proteasome subunit beta type 1, putative	0.0069	0.2194	0.2724
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0021	0.0371	0.0436
Toxoplasma gondii	proteasome subunit alpha type, putative	0.0021	0.0371	0.0436
Giardia lamblia	Proteasome subunit beta type 1	0.0069	0.2194	0.2392
Echinococcus granulosus	Peptidase C19 ubiquitin carboxyl terminal hydrolase 2	0.0043	0.1213	0.1518
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0021	0.0371	0.0436
Echinococcus multilocularis	dual specificity protein kinase clk2	0.0071	0.2274	0.2845
Loa Loa (eye worm)	cytochrome P450	0.0012	0.0023	0.0023
Toxoplasma gondii	proteasome subunit beta type, putative	0.0218	0.7993	1
Plasmodium vivax	multidomain scavenger receptor, putative	0.0023	0.0434	0.0083
Mycobacterium ulcerans	proteasome PrcA	0.0021	0.0371	0.0436
Brugia malayi	Proteasome subunit alpha type 7-1	0.0021	0.0371	0.0371
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.0419	0.0419
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0021	0.0371	0.0371
Loa Loa (eye worm)	proteasome A-type and B-type family protein	0.0021	0.0371	0.0371
Onchocerca volvulus		0.0023	0.0434	1
Loa Loa (eye worm)	doublecortin family protein	0.0023	0.0434	0.0434
Echinococcus granulosus	proteasome subunit alpha type 6	0.0021	0.0371	0.0464
Schistosoma mansoni	proteasome subunit alpha 1 (T01 family)	0.0021	0.0371	0.0464
Schistosoma mansoni	lipoxygenase	0.0023	0.0434	0.0543
Trypanosoma cruzi	proteasome beta-1 subunit, putative	0.0021	0.0371	0.0436
Loa Loa (eye worm)	proteasome subunit beta type 2	0.0021	0.0371	0.0371
Trypanosoma cruzi	20S proteasome subunit	0.0021	0.0371	0.0436
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0021	0.0371	0.0436
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0434	0.0434
Brugia malayi	Proteasome A-type and B-type family protein	0.0021	0.0371	0.0371
Schistosoma mansoni	proteasome subunit alpha 7 (T01 family)	0.0021	0.0371	0.0464
Brugia malayi	proteasome subunit beta type 1	0.0069	0.2194	0.2194
Leishmania major	proteasome beta 2 subunit, putative	0.0021	0.0371	0.0436
Toxoplasma gondii	cell-cycle-associated protein kinase CLK, putative	0.0071	0.2274	0.2824
Echinococcus multilocularis	lipoxygenase domain containing protein	0.0023	0.0434	0.0543
Echinococcus multilocularis	proteasome subunit alpha type 2	0.0021	0.0371	0.0464
Echinococcus multilocularis	arachidonate 5 lipoxygenase	0.0064	0.2036	0.2547
Echinococcus granulosus	subfamily T1A non peptidase ue	0.0021	0.0371	0.0464
Loa Loa (eye worm)	hypothetical protein	0.007	0.2253	0.2253
Brugia malayi	proteasome subunit alpha type 1	0.0021	0.0371	0.0371
Echinococcus granulosus	proteasome prosome macropain subunit beta	0.0021	0.0371	0.0464
Echinococcus granulosus	ubiquitin carboxyl terminal hydrolase 8	0.0043	0.1213	0.1518
Echinococcus multilocularis	Proteasome subunit alpha type 7	0.0021	0.0371	0.0464
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0021	0.0371	0.0464
Brugia malayi	proteasome subunit alpha type 6	0.0021	0.0371	0.0371
Trypanosoma cruzi	hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B	0.0021	0.0371	0.0436
Leishmania major	proteasome alpha 1 subunit, putative	0.0021	0.0371	0.0436
Echinococcus multilocularis	proteasome (prosome macropain) subunit alpha	0.0021	0.0371	0.0464
Toxoplasma gondii	proteasome subunit beta type 7 precursor, putative	0.0021	0.0371	0.0436
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0023	0.0419	0.0496
Echinococcus multilocularis	subfamily T1A non peptidase ue	0.0021	0.0371	0.0464
Schistosoma mansoni	lipoxygenase	0.0064	0.2036	0.2547
Entamoeba histolytica	calcium-dependent protein kinase 2, putative	0.0022	0.0392	0.0027
Trypanosoma brucei	ATP-dependent protease subunit HslV	0.0021	0.0371	0.0436
Schistosoma mansoni	subfamily T1A non-peptidase homologue (T01 family)	0.0021	0.0371	0.0464
Toxoplasma gondii	proteasome subunit alpha type 1, putative	0.0021	0.0371	0.0436
Trypanosoma brucei	ubiquitin carboxyl-terminal hydrolase, putative	0.0043	0.1213	0.1493
Giardia lamblia	Kinase, CMGC CLK	0.0071	0.2274	0.2496
Schistosoma mansoni	proteasome subunit alpha 6 (T01 family)	0.0021	0.0371	0.0464
Loa Loa (eye worm)	proteasome subunit alpha type 7-1	0.0021	0.0371	0.0371
Schistosoma mansoni	ubiquitin-specific peptidase 8 (C19 family)	0.0043	0.1213	0.1518
Entamoeba histolytica	proteasome subunit beta type 5 precursor, putative	0.0218	0.7993	1
Loa Loa (eye worm)	proteasome subunit beta type 3	0.0021	0.0371	0.0371
Echinococcus multilocularis	proteasome subunit beta type 7	0.0021	0.0371	0.0464
Trypanosoma cruzi	proteasome beta 6 subunit, putative	0.0069	0.2194	0.2724
Loa Loa (eye worm)	PAS-3 protein	0.0021	0.0371	0.0371
Leishmania major	hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B	0.0021	0.0371	0.0436
Trypanosoma cruzi	ATP-dependent protease subunit HslV, putative	0.0021	0.0371	0.0436
Brugia malayi	Proteasome subunit alpha type 1	0.0021	0.0371	0.0371
Echinococcus multilocularis	Polycystic kidney disease protein	0.0023	0.0434	0.0543
Echinococcus granulosus	ubiquitin specific protease 41	0.0043	0.1213	0.1518
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.027	1	1
Leishmania major	protein kinase, putative	0.0071	0.2274	0.2824
Trypanosoma cruzi	proteasome beta 3 subunit, putative	0.0021	0.0371	0.0436
Trypanosoma brucei	proteasome subunit beta type-2, putative	0.0021	0.0371	0.0436
Toxoplasma gondii	20S proteasome subunit beta 7, putative	0.0021	0.0371	0.0436
Echinococcus multilocularis	proteasome (prosome, macropain) subunit, beta	0.0069	0.2194	0.2745
Trypanosoma cruzi	proteasome subunit alpha type-5, putative	0.0021	0.0371	0.0436
Loa Loa (eye worm)	cytochrome P450 family protein	0.0023	0.0419	0.0419
Echinococcus multilocularis	proteasome subunit beta type 6	0.0021	0.0371	0.0464
Brugia malayi	Cytochrome P450 family protein	0.0035	0.0884	0.0884
Echinococcus granulosus	Proteasome subunit alpha beta	0.0021	0.0371	0.0464
Trypanosoma cruzi	proteasome subunit beta type-5, putative	0.0218	0.7993	1
Plasmodium falciparum	LCCL domain-containing protein	0.0023	0.0434	0.0083
Leishmania major	20s proteasome beta 7 subunit, (putative)	0.0021	0.0371	0.0436
Trypanosoma brucei	proteasome beta 3 subunit, putative	0.0021	0.0371	0.0436
Echinococcus multilocularis	proteasome subunit alpha type 6	0.0021	0.0371	0.0464
Loa Loa (eye worm)	proteasome subunit alpha type 1	0.0021	0.0371	0.0371
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0021	0.0371	0.0436
Toxoplasma gondii	proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative	0.0021	0.0371	0.0436
Trypanosoma brucei	proteasome alpha 2 subunit, putative	0.0021	0.0371	0.0436
Trypanosoma cruzi	proteasome alpha 1 subunit, putative	0.0021	0.0371	0.0436
Trypanosoma cruzi	proteasome beta 7 subunit, putative	0.0021	0.0371	0.0436
Trypanosoma brucei	proteasome beta 2 subunit, putative	0.0021	0.0371	0.0436
Entamoeba histolytica	proteasome subunit beta type 1, putative	0.0069	0.2194	0.2392
Echinococcus granulosus	cytochrome P450 2K1	0.0012	0.0023	0.0029
Loa Loa (eye worm)	hypothetical protein	0.0023	0.0434	0.0434
Schistosoma mansoni	hypothetical protein	0.0012	0.0023	0.0029
Brugia malayi	cytochrome P450	0.0012	0.0023	0.0023
Trypanosoma brucei	kinetoplastid kinetochore protein 10	0.0071	0.2274	0.2824
Leishmania major	proteasome beta 2 subunit, putative	0.0021	0.0371	0.0436
Leishmania major	proteasome alpha 3 subunit, putative	0.0021	0.0371	0.0436
Leishmania major	proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative)	0.0021	0.0371	0.0436
Toxoplasma gondii	proteasome subunit alpha1, putative	0.0021	0.0371	0.0436
Brugia malayi	proteasome subunit alpha type 2	0.0021	0.0371	0.0371
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0021	0.0371	0.0464
Trichomonas vaginalis	conserved hypothetical protein	0.0043	0.1213	0.1105
Trichomonas vaginalis	Family T1, proteasome beta subunit, threonine peptidase	0.0069	0.2194	0.2392
Plasmodium vivax	serine/threonine kinase-1, putative	0.0071	0.2274	0.2496
Echinococcus multilocularis	proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta	0.0021	0.0371	0.0464
Trypanosoma cruzi	proteasome beta 2 subunit, putative	0.0021	0.0371	0.0436
Trypanosoma brucei	proteasome alpha 7 subunit, putative	0.0021	0.0371	0.0436
Leishmania major	proteasome beta-1 subunit, putative	0.0021	0.0371	0.0436
Schistosoma mansoni	proteasome catalytic subunit 1 (T01 family)	0.0021	0.0371	0.0464
Trypanosoma brucei	proteasome alpha 1 subunit, putative	0.0021	0.0371	0.0436
Loa Loa (eye worm)	CYP4Cod1	0.0023	0.0419	0.0419
Trichomonas vaginalis	Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase	0.0043	0.1213	0.1105
Loa Loa (eye worm)	proteasome subunit alpha type 6	0.0021	0.0371	0.0371
Schistosoma mansoni	proteasome subunit beta 2 (T01 family)	0.0021	0.0371	0.0464
Brugia malayi	Cytochrome P450 family protein	0.0012	0.0023	0.0023
Echinococcus granulosus	proteasome prosome macropain	0.0218	0.7993	1
Trypanosoma brucei	proteasome beta 7 subunit	0.0021	0.0371	0.0436
Plasmodium vivax	proteasome subunit beta type-5, putative	0.0218	0.7993	1
Brugia malayi	hypothetical protein	0.0023	0.0434	0.0434
Leishmania major	proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative	0.0069	0.2194	0.2724
Trypanosoma cruzi	proteasome alpha 7 subunit, putative	0.0021	0.0371	0.0436

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (ADMET)		Neurotoxicity against Mus musculus albino (mouse) at 3 mg/kg, ip after 30 min by rotarod test	ChEMBL.	No reference
Activity (ADMET)	= 0 %	Neurotoxicity against Mus musculus albino (mouse) assessed as inability to climb horizontal screen at 3 mg/kg, ip after 30 min by horizontal screen test relative to control	ChEMBL.	No reference
Activity (ADMET)	= 16.7 %	Neurotoxicity against Mus musculus albino (mouse) assessed as fall from horizontal screen at 3 mg/kg, ip after 30 min by horizontal screen test relative to control	ChEMBL.	No reference
Activity (functional)	= 75 %	Antipsychotic activity in Mus musculus albino (mouse) assessed as ptosis at 3 mg/kg, ip relative to control	ChEMBL.	No reference
Inhibition (functional)		Anticonvulsant activity in Mus musculus albino (mouse) assessed as inhibition of PTZ-induced seizure at 3 mg/kg, ip administered 1 hr prior to PTZ-challenge measured after 2 to 4 min relative to control	ChEMBL.	No reference
TIME (functional)	= 151 s	CNS depressant activity in Mus musculus albino (mouse) assessed as immobility time at 3 mg/kg, ip measured after 24 hr by forced swim test (Rvb = 120 +/- 5.1 secs)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL2283407

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1805661