Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Proteasome, subunit alpha beta | 0.0021 | 0.0371 | 0.0464 |
Leishmania major | protein kinase, putative | 0.0071 | 0.2274 | 0.2824 |
Echinococcus multilocularis | proteasome subunit alpha type 6 | 0.0021 | 0.0371 | 0.0464 |
Leishmania major | ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative | 0.0043 | 0.1213 | 0.1493 |
Leishmania major | cytochrome p450-like protein | 0.0023 | 0.0419 | 0.0496 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0069 | 0.2194 | 0.2745 |
Trypanosoma cruzi | proteasome alpha 2 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Trypanosoma cruzi | proteasome alpha 7 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Echinococcus granulosus | Proteasome subunit alpha beta | 0.0021 | 0.0371 | 0.0464 |
Trypanosoma cruzi | proteasome beta 3 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Leishmania major | 20s proteasome beta 7 subunit, (putative) | 0.0021 | 0.0371 | 0.0436 |
Trypanosoma cruzi | ATP-dependent protease subunit HslV, putative | 0.0021 | 0.0371 | 0.0436 |
Schistosoma mansoni | proteasome subunit alpha 7 (T01 family) | 0.0021 | 0.0371 | 0.0464 |
Echinococcus granulosus | hypothetical protein | 0.007 | 0.2253 | 0.2818 |
Plasmodium vivax | proteasome subunit beta type-5, putative | 0.0218 | 0.7993 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0023 | 0.0419 | 0.0496 |
Brugia malayi | Ubiquitin carboxyl-terminal hydrolase family protein | 0.0043 | 0.1213 | 0.1213 |
Schistosoma mansoni | proteasome subunit alpha 2 (T01 family) | 0.0021 | 0.0371 | 0.0464 |
Trypanosoma brucei | proteasome beta 6 subunit | 0.0069 | 0.2194 | 0.2724 |
Echinococcus granulosus | cytochrome P450 2K1 | 0.0012 | 0.0023 | 0.0029 |
Brugia malayi | Cytochrome P450 family protein | 0.0035 | 0.0884 | 0.0884 |
Leishmania major | proteasome beta 2 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Schistosoma mansoni | proteasome subunit beta 3 (T01 family) | 0.0021 | 0.0371 | 0.0464 |
Loa Loa (eye worm) | proteasome subunit alpha type 1 | 0.0021 | 0.0371 | 0.0371 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0023 | 0.0434 | 0.0543 |
Loa Loa (eye worm) | cytochrome P450 | 0.0012 | 0.0023 | 0.0023 |
Schistosoma mansoni | lipoxygenase | 0.0023 | 0.0434 | 0.0543 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0023 | 0.0434 | 0.0543 |
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0218 | 0.7993 | 1 |
Schistosoma mansoni | rab6-interacting | 0.0023 | 0.0434 | 0.0543 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0023 | 0.0419 | 0.0496 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0434 | 0.0434 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0218 | 0.7993 | 1 |
Trypanosoma cruzi | proteasome subunit alpha type-5, putative | 0.0021 | 0.0371 | 0.0436 |
Schistosoma mansoni | lipoxygenase | 0.0064 | 0.2036 | 0.2547 |
Leishmania major | proteasome alpha 7 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Toxoplasma gondii | proteasome subunit alpha1, putative | 0.0021 | 0.0371 | 0.0436 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0043 | 0.1213 | 0.1105 |
Trypanosoma cruzi | hslVU complex proteolytic subunit, threonine peptidase, Clan T(1), family T1B | 0.0021 | 0.0371 | 0.0436 |
Trypanosoma brucei | cytochrome P450, putative | 0.0023 | 0.0419 | 0.0496 |
Brugia malayi | proteasome subunit alpha type 1 | 0.0021 | 0.0371 | 0.0371 |
Brugia malayi | Protein kinase domain containing protein | 0.0071 | 0.2274 | 0.2274 |
Leishmania major | proteasome beta 5 subunit, putative | 0.0218 | 0.7993 | 1 |
Loa Loa (eye worm) | CMGC/CLK protein kinase | 0.0071 | 0.2274 | 0.2274 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0043 | 0.1213 | 0.1105 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0071 | 0.2274 | 0.2824 |
Trypanosoma cruzi | 20S proteasome subunit | 0.0021 | 0.0371 | 0.0436 |
Leishmania major | proteasome beta-1 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Trichomonas vaginalis | CMGC family protein kinase | 0.0071 | 0.2274 | 0.2496 |
Toxoplasma gondii | proteasome subunit alpha type 5-2, putative | 0.0021 | 0.0371 | 0.0436 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0023 | 0.0419 | 0.0419 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0071 | 0.2274 | 0.2824 |
Toxoplasma gondii | proteasome subunit | 0.0021 | 0.0371 | 0.0436 |
Echinococcus granulosus | Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 | 0.0043 | 0.1213 | 0.1518 |
Plasmodium falciparum | LCCL domain-containing protein | 0.0023 | 0.0434 | 0.0083 |
Mycobacterium tuberculosis | Proteasome alpha subunit PrcA; assembles with beta subunit PrcB. | 0.0021 | 0.0371 | 0.0436 |
Schistosoma mansoni | subfamily T1A non-peptidase homologue (T01 family) | 0.0021 | 0.0371 | 0.0464 |
Leishmania major | 20s proteasome beta 7 subunit, (putative) | 0.0021 | 0.0371 | 0.0436 |
Echinococcus multilocularis | proteasome subunit alpha type 2 | 0.0021 | 0.0371 | 0.0464 |
Brugia malayi | cytochrome P450 | 0.0012 | 0.0023 | 0.0023 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0434 | 0.0434 |
Echinococcus multilocularis | Polycystic kidney disease protein | 0.0023 | 0.0434 | 0.0543 |
Echinococcus multilocularis | proteasome subunit beta (t family) proteasome (prosome macropain) subunit beta | 0.0021 | 0.0371 | 0.0464 |
Echinococcus multilocularis | 0.007 | 0.2253 | 0.2818 | |
Loa Loa (eye worm) | 20S proteasome alpha5 subunit | 0.0021 | 0.0371 | 0.0371 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0069 | 0.2194 | 0.2724 |
Leishmania major | proteasome beta 3 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Echinococcus granulosus | proteasome subunit beta type 6 | 0.0021 | 0.0371 | 0.0464 |
Mycobacterium ulcerans | proteasome PrcA | 0.0021 | 0.0371 | 0.0436 |
Echinococcus granulosus | Proteasome subunit alpha type 7 | 0.0021 | 0.0371 | 0.0464 |
Leishmania major | 20s proteasome beta 7 subunit, (putative) | 0.0021 | 0.0371 | 0.0436 |
Plasmodium falciparum | protein serine/threonine kinase-1 | 0.0071 | 0.2274 | 0.2496 |
Schistosoma mansoni | proteasome subunit alpha 1 (T01 family) | 0.0021 | 0.0371 | 0.0464 |
Brugia malayi | Proteasome subunit alpha type 7-1 | 0.0021 | 0.0371 | 0.0371 |
Echinococcus multilocularis | subfamily T1A non peptidase ue | 0.0021 | 0.0371 | 0.0464 |
Brugia malayi | proteasome subunit alpha type 3 | 0.0021 | 0.0371 | 0.0371 |
Onchocerca volvulus | Notchless protein homolog | 0.0021 | 0.0371 | 0.8547 |
Schistosoma mansoni | subfamily T1A non-peptidase homologue (T01 family) | 0.0021 | 0.0371 | 0.0464 |
Schistosoma mansoni | subfamily T1A non-peptidase homologue (T01 family) | 0.0021 | 0.0371 | 0.0464 |
Trypanosoma brucei | proteasome alpha 1 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0064 | 0.2036 | 0.2547 |
Leishmania major | proteasome alpha 7 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0064 | 0.2036 | 0.2547 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0021 | 0.0371 | 0.0464 |
Trypanosoma brucei | kinetoplastid kinetochore protein 10 | 0.0071 | 0.2274 | 0.2824 |
Trypanosoma cruzi | proteasome beta-1 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Trypanosoma cruzi | proteasome beta-1 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0021 | 0.0371 | 0.0371 |
Schistosoma mansoni | proteasome subunit beta 1 (T01 family) | 0.0069 | 0.2194 | 0.2745 |
Toxoplasma gondii | proteasome subunit beta type 1, putative | 0.0069 | 0.2194 | 0.2724 |
Loa Loa (eye worm) | proteasome subunit alpha type 7-1 | 0.0021 | 0.0371 | 0.0371 |
Trypanosoma brucei | proteasome alpha 2 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Trypanosoma brucei | proteasome subunit alpha type-5, putative | 0.0021 | 0.0371 | 0.0436 |
Schistosoma mansoni | proteasome subunit alpha 6 (T01 family) | 0.0021 | 0.0371 | 0.0464 |
Loa Loa (eye worm) | proteasome subunit alpha type 6 | 0.0021 | 0.0371 | 0.0371 |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0218 | 0.7993 | 1 |
Brugia malayi | Doublecortin family protein | 0.0023 | 0.0434 | 0.0434 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0069 | 0.2194 | 0.2392 |
Leishmania major | proteasome beta 7 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Giardia lamblia | Proteasome subunit beta type 1 | 0.0069 | 0.2194 | 0.2392 |
Schistosoma mansoni | proteasome catalytic subunit 1 (T01 family) | 0.0021 | 0.0371 | 0.0464 |
Trypanosoma brucei | ATP-dependent protease subunit HslV | 0.0021 | 0.0371 | 0.0436 |
Mycobacterium ulcerans | proteasome PrcB | 0.0218 | 0.7993 | 1 |
Trypanosoma brucei | proteasome alpha 3 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Toxoplasma gondii | proteasome subunit alpha type, putative | 0.0021 | 0.0371 | 0.0436 |
Trypanosoma cruzi | proteasome beta 2 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Trypanosoma cruzi | proteasome alpha 7 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Trypanosoma brucei | proteasome beta 3 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0021 | 0.0371 | 0.0371 |
Trypanosoma brucei | ubiquitin carboxyl-terminal hydrolase, putative | 0.0043 | 0.1213 | 0.1493 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0218 | 0.7993 | 0.7993 |
Trypanosoma brucei | proteasome beta-1 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Echinococcus granulosus | dual specificity protein kinase clk2 | 0.0071 | 0.2274 | 0.2845 |
Trypanosoma brucei | proteasome alpha 7 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0218 | 0.7993 | 1 |
Echinococcus multilocularis | proteasome (prosome macropain) subunit alpha | 0.0021 | 0.0371 | 0.0464 |
Leishmania major | proteasome alpha 2 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Trypanosoma cruzi | proteasome beta 7 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Trypanosoma cruzi | proteasome subunit beta type-5, putative | 0.0218 | 0.7993 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) subunit, beta | 0.0021 | 0.0371 | 0.0464 |
Loa Loa (eye worm) | hypothetical protein | 0.007 | 0.2253 | 0.2253 |
Toxoplasma gondii | 20S proteasome subunit beta 7, putative | 0.0021 | 0.0371 | 0.0436 |
Echinococcus granulosus | proteasome subunit alpha type 2 | 0.0021 | 0.0371 | 0.0464 |
Schistosoma mansoni | proteasome subunit alpha 4 (T01 family) | 0.0021 | 0.0371 | 0.0464 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0021 | 0.0371 | 0.0371 |
Echinococcus granulosus | proteasome subunit alpha type 6 | 0.0021 | 0.0371 | 0.0464 |
Echinococcus multilocularis | proteasome subunit beta type 7 | 0.0021 | 0.0371 | 0.0464 |
Brugia malayi | proteasome subunit alpha type 2 | 0.0021 | 0.0371 | 0.0371 |
Loa Loa (eye worm) | proteasome subunit beta type 2 | 0.0021 | 0.0371 | 0.0371 |
Schistosoma mansoni | cytochrome P450 | 0.0012 | 0.0023 | 0.0029 |
Schistosoma mansoni | polycystin 1-related | 0.0023 | 0.0434 | 0.0543 |
Giardia lamblia | Kinase, CMGC CLK | 0.0071 | 0.2274 | 0.2496 |
Trypanosoma brucei | proteasome beta 2 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0023 | 0.0419 | 0.0419 |
Schistosoma mansoni | proteasome subunit alpha 3 (T01 family) | 0.0021 | 0.0371 | 0.0464 |
Leishmania major | proteasome beta 6 subunit, putative,20S proteasome beta 6 subunit, putative | 0.0069 | 0.2194 | 0.2724 |
Onchocerca volvulus | 0.0023 | 0.0434 | 1 | |
Brugia malayi | proteasome subunit alpha type 6 | 0.0021 | 0.0371 | 0.0371 |
Trypanosoma brucei | proteasome beta 7 subunit | 0.0021 | 0.0371 | 0.0436 |
Trypanosoma brucei | kinetoplastid kinetochore protein 19 | 0.0071 | 0.2274 | 0.2824 |
Loa Loa (eye worm) | PAS-3 protein | 0.0021 | 0.0371 | 0.0371 |
Echinococcus multilocularis | dual specificity protein kinase clk2 | 0.0071 | 0.2274 | 0.2845 |
Leishmania major | hs1vu complex proteolytic subunit-like,hs1vu complex proteolytic subunit-like, threonine peptidase, Clan T(1), family T1B | 0.0021 | 0.0371 | 0.0436 |
Brugia malayi | proteasome subunit alpha type 4 | 0.0021 | 0.0371 | 0.0371 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0071 | 0.2274 | 0.2845 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0218 | 0.7993 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.0023 | 0.0023 |
Trypanosoma cruzi | proteasome subunit alpha type-1, putative | 0.0021 | 0.0371 | 0.0436 |
Echinococcus multilocularis | 20S proteasome subunit alpha 6 | 0.0021 | 0.0371 | 0.0464 |
Toxoplasma gondii | proteasome subunit beta type 2, putative | 0.0021 | 0.0371 | 0.0436 |
Brugia malayi | Cytochrome P450 family protein | 0.0023 | 0.0419 | 0.0419 |
Trichomonas vaginalis | Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase | 0.0043 | 0.1213 | 0.1105 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0021 | 0.0371 | 0.0464 |
Loa Loa (eye worm) | proteasome subunit beta type 3 | 0.0021 | 0.0371 | 0.0371 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1213 | 0.1213 |
Leishmania major | proteasome alpha 3 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Leishmania major | 20s proteasome beta 7 subunit, (putative) | 0.0021 | 0.0371 | 0.0436 |
Echinococcus multilocularis | 0.0012 | 0.0023 | 0.0029 | |
Brugia malayi | Proteasome subunit alpha type 1 | 0.0021 | 0.0371 | 0.0371 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent protease peptidase subunit | 0.0021 | 0.0371 | 0.5 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0218 | 0.7993 | 1 |
Brugia malayi | proteasome subunit beta type 2 | 0.0021 | 0.0371 | 0.0371 |
Loa Loa (eye worm) | proteasome subunit alpha type 2 | 0.0021 | 0.0371 | 0.0371 |
Schistosoma mansoni | proteasome subunit beta 4 (T01 family) | 0.0021 | 0.0371 | 0.0464 |
Toxoplasma gondii | proteasome subunit beta type, putative | 0.0218 | 0.7993 | 1 |
Toxoplasma gondii | heat shock protein hslv, putative | 0.0021 | 0.0371 | 0.0436 |
Loa Loa (eye worm) | proteasome subunit alpha type 3 | 0.0021 | 0.0371 | 0.0371 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0069 | 0.2194 | 0.2745 |
Echinococcus granulosus | ubiquitin specific protease 41 | 0.0043 | 0.1213 | 0.1518 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0043 | 0.1213 | 0.1493 |
Brugia malayi | Cytochrome P450 family protein | 0.0023 | 0.0419 | 0.0419 |
Echinococcus granulosus | proteasome subunit beta t family | 0.0021 | 0.0371 | 0.0464 |
Trypanosoma cruzi | proteasome alpha 2 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Toxoplasma gondii | proteasome subunit alpha type 1, putative | 0.0021 | 0.0371 | 0.0436 |
Trypanosoma cruzi | proteasome alpha 7 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Leishmania major | protein kinase, putative | 0.0071 | 0.2274 | 0.2824 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.027 | 1 | 1 |
Leishmania major | proteasome alpha 5 subunit, putative,20S proteasome subunit alpha 5, (putative) | 0.0021 | 0.0371 | 0.0436 |
Trypanosoma cruzi | proteasome subunit beta type-2, putative | 0.0021 | 0.0371 | 0.0436 |
Toxoplasma gondii | cell-cycle-associated protein kinase CLK, putative | 0.0071 | 0.2274 | 0.2824 |
Brugia malayi | proteasome subunit beta type 1 | 0.0069 | 0.2194 | 0.2194 |
Leishmania major | 20s proteasome beta 7 subunit, (putative) | 0.0021 | 0.0371 | 0.0436 |
Echinococcus granulosus | subfamily T1A non peptidase ue | 0.0021 | 0.0371 | 0.0464 |
Echinococcus multilocularis | proteasome subunit beta type 6 | 0.0021 | 0.0371 | 0.0464 |
Entamoeba histolytica | calcium-dependent protein kinase 2, putative | 0.0022 | 0.0392 | 0.0027 |
Plasmodium vivax | multidomain scavenger receptor, putative | 0.0023 | 0.0434 | 0.0083 |
Trypanosoma cruzi | proteasome alpha 7 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Schistosoma mansoni | ubiquitin-specific peptidase 2 (C19 family) | 0.0043 | 0.1213 | 0.1518 |
Plasmodium vivax | proteasome subunit beta type-1, putative | 0.0069 | 0.2194 | 0.2392 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0021 | 0.0371 | 0.0371 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 10, putative | 0.0071 | 0.2274 | 0.2824 |
Onchocerca volvulus | 0.0023 | 0.0434 | 1 | |
Brugia malayi | proteasome subunit beta type 3 | 0.0021 | 0.0371 | 0.0371 |
Brugia malayi | hypothetical protein | 0.0023 | 0.0434 | 0.0434 |
Echinococcus granulosus | 20S proteasome subunit alpha 6 | 0.0021 | 0.0371 | 0.0464 |
Echinococcus multilocularis | lipoxygenase domain containing protein | 0.0023 | 0.0434 | 0.0543 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0071 | 0.2274 | 0.2845 |
Trypanosoma brucei | Proteasome subunit A N-terminal signature/Proteasome subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Trypanosoma cruzi | proteasome beta 3 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Schistosoma mansoni | ubiquitin-specific peptidase 8 (C19 family) | 0.0043 | 0.1213 | 0.1518 |
Trypanosoma cruzi | proteasome alpha 3 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Plasmodium vivax | serine/threonine kinase-1, putative | 0.0071 | 0.2274 | 0.2496 |
Toxoplasma gondii | proteasome subunit alpha2, protease of the acylase family and NTN hydrolase fold, putative | 0.0021 | 0.0371 | 0.0436 |
Schistosoma mansoni | proteasome subunit beta 3 (T01 family) | 0.0021 | 0.0371 | 0.0464 |
Leishmania major | proteasome alpha 1 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Giardia lamblia | Ubiquitin carboxyl-terminal hydrolase 4 | 0.0043 | 0.1213 | 0.1105 |
Schistosoma mansoni | hypothetical protein | 0.0012 | 0.0023 | 0.0029 |
Schistosoma mansoni | proteasome subunit beta 2 (T01 family) | 0.0021 | 0.0371 | 0.0464 |
Echinococcus multilocularis | Proteasome subunit alpha type 7 | 0.0021 | 0.0371 | 0.0464 |
Loa Loa (eye worm) | doublecortin family protein | 0.0023 | 0.0434 | 0.0434 |
Echinococcus multilocularis | proteasome (prosome macropain) subunit beta type | 0.0021 | 0.0371 | 0.0464 |
Mycobacterium leprae | probable proteasome (alpha subunit) PrcA | 0.0021 | 0.0371 | 0.0436 |
Entamoeba histolytica | proteasome subunit beta type 1, putative | 0.0069 | 0.2194 | 0.2392 |
Echinococcus granulosus | proteasome subunit beta type 7 | 0.0021 | 0.0371 | 0.0464 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0023 | 0.0419 | 0.0419 |
Leishmania major | proteasome beta 2 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Echinococcus granulosus | ubiquitin carboxyl terminal hydrolase 8 | 0.0043 | 0.1213 | 0.1518 |
Schistosoma mansoni | rab6-interacting | 0.0023 | 0.0434 | 0.0543 |
Trypanosoma brucei | proteasome alpha 7 subunit | 0.0021 | 0.0371 | 0.0436 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0021 | 0.0371 | 0.0371 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0218 | 0.7993 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0035 | 0.0884 | 0.0884 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0434 | 0.0434 |
Echinococcus multilocularis | RUN | 0.0023 | 0.0434 | 0.0543 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0023 | 0.0419 | 0.0496 |
Trypanosoma cruzi | proteasome beta 6 subunit, putative | 0.0069 | 0.2194 | 0.2724 |
Echinococcus granulosus | RUN | 0.0023 | 0.0434 | 0.0543 |
Trypanosoma cruzi | proteasome alpha 1 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Trypanosoma brucei | proteasome subunit beta type-2, putative | 0.0021 | 0.0371 | 0.0436 |
Echinococcus granulosus | lipoxygenase domain containing protein | 0.0023 | 0.0434 | 0.0543 |
Echinococcus granulosus | proteasome prosome macropain subunit beta type | 0.0021 | 0.0371 | 0.0464 |
Echinococcus multilocularis | ubiquitin specific protease 41 | 0.0043 | 0.1213 | 0.1518 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0218 | 0.7993 | 1 |
Echinococcus multilocularis | Proteasome subunit alpha type 7 | 0.0021 | 0.0371 | 0.0464 |
Schistosoma mansoni | proteasome catalytic subunit 2 (T01 family) | 0.0021 | 0.0371 | 0.0464 |
Echinococcus multilocularis | ubiquitin carboxyl terminal hydrolase 8 | 0.0043 | 0.1213 | 0.1518 |
Plasmodium falciparum | proteasome subunit beta type-5 | 0.0218 | 0.7993 | 1 |
Echinococcus granulosus | proteasome prosome macropain subunit alpha | 0.0021 | 0.0371 | 0.0464 |
Trypanosoma cruzi | ubiquitin carboxyl-terminal hydrolase, putative | 0.0043 | 0.1213 | 0.1493 |
Trypanosoma cruzi | proteasome alpha 3 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Echinococcus multilocularis | Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 | 0.0043 | 0.1213 | 0.1518 |
Trypanosoma cruzi | proteasome subunit alpha type-5, putative | 0.0021 | 0.0371 | 0.0436 |
Entamoeba histolytica | ubiquitin carboxyl-terminal hydrolase domain containing protein | 0.0043 | 0.1213 | 0.1105 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0434 | 0.0543 |
Toxoplasma gondii | peptidase, T1 family protein | 0.0021 | 0.0371 | 0.0436 |
Toxoplasma gondii | proteasome subunit beta type 7 precursor, putative | 0.0021 | 0.0371 | 0.0436 |
Trypanosoma cruzi | proteasome alpha 1 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Echinococcus granulosus | proteasome prosome macropain | 0.0218 | 0.7993 | 1 |
Trypanosoma cruzi | kinetoplastid kinetochore protein 19, putative | 0.0071 | 0.2274 | 0.2824 |
Leishmania major | proteasome alpha 1 subunit, putative | 0.0021 | 0.0371 | 0.0436 |
Echinococcus granulosus | proteasome prosome macropain subunit beta | 0.0021 | 0.0371 | 0.0464 |
Brugia malayi | 20S proteasome alpha5 subunit | 0.0021 | 0.0371 | 0.0371 |
Leishmania major | 20s proteasome beta 7 subunit, (putative) | 0.0021 | 0.0371 | 0.0436 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0021 | 0.0371 | 0.0371 |
Echinococcus multilocularis | Proteasome subunit alpha type 7 | 0.0021 | 0.0371 | 0.0464 |
Plasmodium falciparum | proteasome subunit beta type-1, putative | 0.0069 | 0.2194 | 0.2392 |
Schistosoma mansoni | loxhd1 | 0.0023 | 0.0434 | 0.0543 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0218 | 0.7993 | 0.7993 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0218 | 0.7993 | 1 |
Loa Loa (eye worm) | proteasome subunit beta type 1 | 0.0069 | 0.2194 | 0.2194 |
Toxoplasma gondii | proteasome beta subunit | 0.0021 | 0.0371 | 0.0436 |
Echinococcus granulosus | Polycystic kidney disease protein | 0.0023 | 0.0434 | 0.0543 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | Neurotoxicity against Mus musculus albino (mouse) at 3 mg/kg, ip after 30 min by rotarod test | ChEMBL. | No reference | |
Activity (ADMET) | = 0 % | Neurotoxicity against Mus musculus albino (mouse) assessed as inability to climb horizontal screen at 3 mg/kg, ip after 30 min by horizontal screen test relative to control | ChEMBL. | No reference |
Activity (ADMET) | = 16.7 % | Neurotoxicity against Mus musculus albino (mouse) assessed as fall from horizontal screen at 3 mg/kg, ip after 30 min by horizontal screen test relative to control | ChEMBL. | No reference |
Activity (functional) | = 75 % | Antipsychotic activity in Mus musculus albino (mouse) assessed as ptosis at 3 mg/kg, ip relative to control | ChEMBL. | No reference |
Inhibition (functional) | Anticonvulsant activity in Mus musculus albino (mouse) assessed as inhibition of PTZ-induced seizure at 3 mg/kg, ip administered 1 hr prior to PTZ-challenge measured after 2 to 4 min relative to control | ChEMBL. | No reference | |
TIME (functional) | = 151 s | CNS depressant activity in Mus musculus albino (mouse) assessed as immobility time at 3 mg/kg, ip measured after 24 hr by forced swim test (Rvb = 120 +/- 5.1 secs) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.