TDR Targets

Detailed view for ML1323

Basic information

TDR Targets ID: 255693
Mycobacterium leprae, probable proteasome (alpha subunit) PrcA
Source Database / ID: Leproma

pI: 7.1675 | Length (AA): 265 | MW (Da): 28677 | Paralog Number: 0

Signal peptide: N | GPI Anchor: | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Network

Pfam domains

PF00227 Proteasome subunit

Gene Ontology

Mouse over links to read term descriptions.

GO:0019773 proteasome core complex, alpha-subunit complex
GO:0005839 proteasome core complex
GO:0004298 threonine endopeptidase activity
GO:0051603 proteolysis involved in cellular protein catabolic process

Metabolic Pathways

Proteasome (KEGG)

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg	Target End	Template	Template Beg	Template End	Identity	Evalue	Model Score	MPQS	zDope
8	234	3mi0 (A)	8	234	95.00	0	1	1.9948	-1.46
8	244	3h4p (A)	17	244	18.00	0.0000075	1	1.08564	-0.23

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

2FHG:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

2FHH:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

3H6F:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

3H6I:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

3HF9:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

3HFA:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

3KRD:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

3MFE:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

3MI0:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

3MKA:

Resolution	Method	# Atoms	# Residues	Dep. Date	Pub. Date	Mod. Date

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_234682)

Species	Accession	Gene Product
Mycobacterium leprae	ML1323	probable proteasome (alpha subunit) PrcA
Mycobacterium tuberculosis	Rv2109c	Proteasome alpha subunit PrcA; assembles with beta subunit PrcB.
Mycobacterium ulcerans	MUL_2330	proteasome PrcA

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

Annotated phenotypes:

Affected Entity	Phenotypic quality	Occurs in	Occurs at	Evidence	Observed in	Drugs/Inhibitors
catalytic activity (GO:0003824)	decreased (PATO:0000468)	in vitro (MI:0492)		inferred from specific protein inhibition (ECO:0000020)	Mycobacterium tuberculosis	0 155263 157281 352834 531865 546212 562837 562838 562839 562840 562841 562842 562843 562844 562845 562846 562847 562848 562849 562850 562851
Annotator:	crowther@u.washington.edu.	Comment:	2007-12-28.		References:	16468985

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

Compound	Source	Reference
	Curated by TDRTargets	References
	Curated by TDRTargets	References
	Curated by TDRTargets	References
	Curated by TDRTargets	References
	Curated by TDRTargets	References
	Curated by TDRTargets	References
	Curated by TDRTargets	References
	Curated by TDRTargets	References
	Curated by TDRTargets	References
	Curated by TDRTargets	References
	Curated by TDRTargets	References
	Curated by TDRTargets	References
	Curated by TDRTargets	References
	Curated by TDRTargets	References
	Curated by TDRTargets	References
	Curated by TDRTargets	References
	Curated by TDRTargets	References
	Curated by TDRTargets	References
	Curated by TDRTargets	References
	Curated by TDRTargets	References

Predicted associations

By orthology with druggable targets

Non orthologous druggable targets

By sequence similarity to non orthologous druggable targets

No additional associated druggable targets

Ranking Plot

Putative Drugs List

Raw	Global	Species
0.0904	0.2525	1
0.0898	0.668	1
0.0827	0.9853	1
0.0865	0.5325	1
0.0894	0.4128	1
0.0791	0.5728	1
0.0926	0.2622	1
0.0789	0.6718	1
0.215333	1	1
0.114417	1	1
0.085	0.5807	1
0.0948	0.2573	1
0.0908	0.6408	1
0.0837	0.5332	1
0.0262	0.6473	1
0.0891	0.7022	1
0.0656	0.2725	1
0.0858	0.2654	1
0.0926	0.2622	1
0.0904	0.2525	1
0.163	0.8662	1
0.0794	0.7597	0.5
0.0808	0.6442	0.5
0.0906	0.3823	1
0.0837	0.6961	1
0.0865	0.4064	0.9234
0.0876	0.4227	1
0.0879	0.5211	1
0.086	0.6254	1
0.0953	0.2625	1
0.0803	0.5725	1
0.1784	0.7186	1
0.0959	0.8945	0.5
0.129023	0.368084	1
0.0802	0.3595	1
0.083	0.791	1
0.0863	0.307	1
0.087	0.4744	1
0.0834	0.3166	1
0.1712	0.6108	1
0.0834	0.4763	1
0.0938	0.2521	1
0.1711	0.4469	1
0.0827	0.9252	1
0.0863	0.4991	1
0.081	0.8534	1
0.0898	0.668	1
0.215359	0.416714	1
0.0927	0.6446	1
0.0797	0.9167	0.5
0.0858	0.9921	1
0.0825	0.2918	1
0.103219	1	1
0.0905	0.6104	1
0.0853	0.3075	1
0.0927	0.5763	1
0.0849	0.2567	1
0.0796	0.4734	1
0.088	0.3527	1
0.0884	0.5955	1
0.048	0.26	1
0.0834	0.2617	1
0.085	0.2636	1
0.0766	0.4366	1
0.0818	0.6386	1
0.0842	0.5933	1
0.0823	0.6095	1
0.0904	0.5006	1
0.0809	0.8779	1
0.0796	0.4734	1
0.083	0.8542	1
0.0867	0.6073	1
0.0845	0.3806	0.5
0.0355	0.2903	1
0.1073	0.4605	1
0.0827	0.3294	1
0.083	0.9548	1
0.0986	0.2804	0.8385
0.0758	0.3967	1
0.0821	0.4136	1
0.0814	0.9639	1
0.0863	0.4991	1
0.0816	0.7911	1
0.0821	0.4136	1
0.0812	0.5022	1
0.0796	0.4734	1
0.0884	0.3798	1
0.0727	0.3042	1
0.0799	0.4572	1
0.0947	0.9666	1
0.0838	0.511	0.5
0.0828	0.6545	1
0.0791	0.4957	1
0.0863	0.4991	1
0.1628	0.7537	1
0.1073	0.4341	1
0.0864	0.4939	0.5
0.0927	0.6446	1
0.0853	0.4599	1
0.0818	0.6448	1
0.0848	0.265	1
0.0891	0.7022	1
0.0805	0.9314	1
0.0791	0.4957	1
0.0798	0.9935	1
0.0837	0.7185	1
0.0827	0.3294	1
0.0796	0.4252	1
0.0677	0.3519	1
0.0819	0.994	1
0.0874	0.4496	1
0.0094	0.2614	0
0.0722	0.7872	1
0.0813	0.8536	1
0.0815	0.3249	1
0.0935	0.2621	1
0.081	0.8791	0.5
0.024	0.3136	1
0.0834	0.5056	1
0.0906	0.3701	1
0.0834	0.494	1
0.0945	0.6459	1
0.0366	0.5143	1
0.0889	0.3455	1
0.0827	0.6019	1
0.0922	0.2627	1
0.1667	0.6705	1
0.0805	0.3789	1
0.0889	0.6429	1
0.1726	0.6951	1
0.0308	0.4245	1
0.0812	0.4806	1
0.0892	0.3564	1
0.0863	0.4991	1
0.0945	0.6456	1
0.0879	0.9921	1
0.0853	0.3075	1
0.083	0.5034	1
0.0813	0.9707	1
0.0829	0.6075	1
0.0827	0.685	1
0.0801	0.7737	0.5
0.0849	0.5324	1
0.085	0.2636	1
0.0961	0.4268	1
0.0961	0.4268	1
0.0893	0.7269	1
0.0096	0.2611	0
0.0924	0.5121	1
0.0863	0.5018	1
0.0842	0.7126	1
0.048	0.804	1
0.0865	0.746	1
0.0804	0.8463	0.5
0.0809	0.9421	1
0.0907	0.6684	1
0.0856	0.6187	1
0.0853	0.3075	1
0.0931	0.4432	1
0.0945	0.6372	1
0.0905	0.5617	1
0.0842	0.7126	1
0.0791	0.4696	1
0.0801	0.3229	1
0.120021	1	0.5
0.0872	0.5324	1
0.0814	0.4372	1
0.048	0.3416	1
0.0797	0.4716	1
0.0884	0.3798	1
0.0845	0.9377	1
0.0865	0.4064	0.9234
0.0859	0.4106	1
0.0819	0.9539	1
0.0262	0.6473	1
0.0792	0.7331	1
0.0821	0.4298	1
0.089	0.656	1
0.0908	0.4603	1
0.0853	0.5811	1
0.0811	0.3106	1
0.0863	0.4991	1
0.0805	0.8155	1
0.120021	1	0.5
0.0853	0.3075	1
0.0843	0.4182	1
0.0803	0.2902	1
0.082	0.9838	1
0.0893	0.4306	1
0.0818	0.7501	1
0.0927	0.6457	1
0.083	0.5694	1
0.0796	0.7582	1
0.0791	0.3359	1
0.0322	0.4488	0.7895
0.0509	0.8688	1
0.0735	0.4435	1
0.0965	0.5936	1
0.0902	0.6554	1
0.0853	0.5372	1
0.0802	0.5359	1
0.0853	0.3075	1
0.0872	0.4116	1
0.0755	0.3969	1
0.0817	0.8277	1
0.083	0.6096	1
0.1593	0.3824	1
0.103219	1	1
0.082	0.2918	1
0.1667	0.6705	1
0.0801	0.5492	1
0.048	0.8553	1
0.0865	0.4064	0.9234
0.1788	0.455	0.5
0.081	0.7582	1
0.0794	0.9601	1
0.0795	0.3928	1
0.0796	0.4734	1
0.1593	0.3824	1
0.0908	0.641	1
0.082	0.8117	1
0.0946	0.3169	1
0.0802	0.5313	1
0.0797	0.888	1
0.0677	0.3519	1
0.0874	0.4496	1
0.0814	0.5955	1
0.0805	0.5682	1
0.0898	0.6559	1
0.0925	0.5854	1
0.0791	0.5728	1
0.0821	0.879	1
0.082	0.8117	1
0.0194	0.6006	1
0.0834	0.5094	1
0.110591	1	1
0.0799	0.4572	1
0.0827	0.4927	1
0.0799	0.4572	1
0.0946	0.3169	1
0.0853	0.3075	1
0.0802	0.3595	1
0.0834	0.494	1
0.0789	0.5467	1
0.0825	0.2617	1
0.1645	0.3335	1
0.0927	0.4389	1
0.0503	0.3416	1
0.0892	0.2553	1
0.0541	0.6053	1
0.0872	0.4116	1
0.0843	0.4182	1
0.0879	0.5211	1
0.0831	0.5668	1
0.1712	0.6108	1
0.0886	0.4276	1
0.1643	0.7518	1
0.0811	0.9866	1
0.0195	0.2531	0
0.0856	0.5206	1
0.0905	0.5558	1
0.081	0.8534	1
0.0796	0.4734	1
0.081	0.5457	1
0.087	0.5156	1
0.0813	0.9521	1
0.0503	0.3407	1
0.0863	0.4991	1
0.0262	0.6473	1
0.109548	1	1
0.0799	0.9181	1
0.0509	0.8688	1
0.0796	0.9006	1
0.0867	0.8822	0.5
0.0874	0.4496	1
0.086	0.7046	1
0.0825	0.6019	1
0.082	0.2918	1
0.083	0.4827	1
0.0874	0.7429	1
0.0889	0.3455	1
0.0906	0.6555	1
0.1788	0.455	0.5
0.0791	0.3359	1
0.0815	0.4804	1
0.0927	0.5684	1
0.0736	0.3969	1
0.0824	0.8387	1
0.0816	0.8314	1
0.0872	0.4187	1
0.0883	0.2527	1
0.0817	0.4874	0.4849
0.0907	0.6187	1
0.0577	0.568	0.5
0.0801	0.5571	1
0.0863	0.4991	1
0.081	0.5961	1
0.0307	0.3327	1
0.0813	0.3814	1
0.1788	0.455	0.5
0.083	0.5202	1
0.0824	0.7756	1
0.0934	0.2574	1
0.0789	0.6718	1
0.0789	0.4562	1
0.0777	0.8141	1
0.0856	0.5991	1
0.0873	0.873	1
0.0842	0.705	1
0.0829	0.3127	1
0.0825	0.9144	1
0.0808	0.4843	1
0.0791	0.8017	1
0.0924	0.503	1
0.0816	0.8305	1
0.0926	0.2622	1
0.104553	1	1
0.089	0.3088	0.6342
0.1902	0.5544	1
0.0825	0.4815	1
0.0509	0.9495	1
0.0791	0.2734	1
0.0853	0.5969	1
0.0821	0.4136	1
0.0802	0.5005	1
0.0889	0.3455	1
0.0853	0.3132	1
0.0817	0.4874	0.4849
0.0802	0.3595	1
0.084	0.767	0.5
0.0894	0.4128	1
0.0808	0.5996	1
0.0834	0.4964	1
0.0927	0.4416	1
0.0802	0.9856	1
0.0503	0.3407	1
0.088	0.3527	1
0.0906	0.3823	1
0.081	0.7582	1
0.1645	0.3335	1
0.093	0.2601	1
0.0801	0.3229	1
0.0735	0.4435	1
0.0865	0.5472	1
0.0541	0.6053	1
0.1713	0.4169	0.5
0.0738	0.7526	1
0.082	0.9694	1
0.0842	0.7126	1
0.0889	0.5339	1
0.0801	0.3229	1
0.0856	0.5206	1
0.0804	0.4967	1
0.106444	1	0.5
0.1645	0.3335	1
0.0802	0.5051	1
0.0898	0.668	1
0.0945	0.6459	1
0.0791	0.5728	1
0.0865	0.4064	0.9234
0.0803	0.2902	1
0.0827	0.768	1
0.0874	0.3492	1
0.0865	0.4064	0.9234
0.0818	0.9656	1
0.0884	0.3798	1
0.082	0.2918	1
0.0825	0.8522	1
0.0913	0.2596	1
0.1645	0.3335	1
0.0798	0.2879	1
0.08	0.958	1
0.0804	0.8463	0.5
0.0884	0.3798	1
0.0793	0.4963	1
0.0792	0.4884	0.4859
0.0852	0.957	1
0.0812	0.9572	1
0.0791	0.7367	1
0.0853	0.5969	1
0.0834	0.494	1
0.0808	0.5674	1
0.0801	0.3229	1
0.104553	1	0.5
0.0819	0.5108	1
0.0818	0.8551	1
0.0853	0.5969	1
0.0262	0.6473	1
0.111021	1	1
0.0793	0.4963	1
0.0904	0.2583	0.9996
0.1598	0.5534	0.5
0.08	0.5511	1
0.1593	0.3824	1
0.0789	0.8562	1
0.0834	0.494	1
0.129023	0.368084	1
0.1768	0.6744	1
0.0801	0.3229	1
0.0986	0.2677	0.802
0.0826	0.6409	1
0.0796	0.9211	1
0.0842	0.5764	1
0.0845	0.8482	1
0.0926	0.2622	1
0.08	0.4854	1
0.0852	0.5186	1
0.0894	0.4128	1
0.0796	0.4734	1
0.0831	0.5177	1
0.0831	0.5668	1
0.0845	0.6205	1
0.084	0.5026	1
0.0477	0.3248	1
0.0904	0.2583	0.9996
0.0959	0.8945	0.5
0.0807	0.6813	1
0.0804	0.6522	0.5
0.0884	0.3798	1
0.0799	0.9355	1
0.0824	0.316	1
0.08	0.4854	1
0.0853	0.3075	1
0.0813	0.4632	1
0.0825	0.4815	1
0.0792	0.4884	0.4859
0.0794	0.6503	1
0.082	0.2918	1
0.0865	0.5472	1
0.0872	0.4739	1
0.048	0.2599	1
0.0853	0.5516	1
0.0789	0.5355	1
0.0799	0.4718	1
0.088	0.7336	1
0.0804	0.4984	0.5
0.0858	0.9921	1
0.0972	0.6326	1
0.0886	0.9404	1
0.1593	0.3824	1
0.0927	0.6446	1
0.1628	0.7537	1
0.0817	0.9859	1
0.0308	0.4245	1
0.0796	0.7376	1
0.0308	0.4245	1
0.0801	0.5555	1
0.0514	0.2597	0.3475
0.0884	0.3798	1
0.0818	0.9656	1
0.0906	0.3701	1
0.0948	0.2573	1
0.081	0.7522	1
0.0906	0.3701	1
0.0892	0.3564	1
0.0986	0.2933	0.8774
0.0834	0.4763	1
0.0889	0.5339	1
0.0966	0.6036	1
0.0845	0.9895	1
0.0819	0.6082	1
0.079	0.9804	1
0.0809	0.8779	1
0.0863	0.4991	1
0.0896	0.9135	0.5
0.0803	0.4854	1
0.210465	1	0.5
0.0541	0.6053	1
0.0889	0.4835	1
0.0853	0.3075	1
0.0874	0.2795	1
0.0804	0.8463	0.5
0.0796	0.6454	0.4212
0.0834	0.3166	1
0.0819	0.5108	1
0.0922	0.9413	1
0.103936	0.607669	0.5
0.0835	0.2576	1
0.0805	0.5096	1
0.0834	0.494	1
0.0908	0.4603	1
0.0812	0.6347	1
0.082	0.2918	1
0.0909	0.2576	1
0.0853	0.3075	1
0.0821	0.5923	1
0.0853	0.3075	1
0.0796	0.6454	0.4212
0.0818	0.6427	1
0.0863	0.4991	1
0.0815	0.4804	1
0.0884	0.5955	1
0.0541	0.6053	1
0.0804	0.8233	1
0.0946	0.3169	1
0.0809	0.2867	1
0.0906	0.3701	1
0.0882	0.3937	1
0.0872	0.5982	1
0.0799	0.3464	1
0.0828	0.6545	1
0.024	0.3136	1
0.1799	0.7181	1
0.0813	0.5279	1
0.1757	0.9509	1
0.0863	0.4991	1
0.0827	0.768	1
0.0807	0.8781	1
0.0882	0.3937	1
0.0797	0.4868	1
0.0848	0.4957	1
0.0863	0.4991	1
0.0805	0.5104	1
0.0823	0.6095	1
0.0884	0.3798	1
0.0799	0.9181	1
0.0796	0.6454	0.4212
0.0922864	1	1
0.1628	0.7537	1
0.0858	0.2654	1
0.0266	0.313	0.5
0.0885	0.6017	1
0.0972	0.6326	1
0.1712	0.6108	1
0.081	0.8534	1
0.0821	0.4136	1
0.0799	0.4572	1
0.0945	0.5742	1
0.024	0.3136	1
0.0794	0.6254	1
0.109548	1	1
0.210465	1	0.5
0.085	0.8927	1
0.0262	0.6473	1
0.0802	0.3595	1
0.0835	0.2576	1
0.0802	0.4651	1
0.0986	0.2804	0.8385
0.0913	0.2924	1
0.0906	0.3701	1
0.085	0.3319	1
0.0913	0.2924	1
0.0794	0.9276	0.5
0.089	0.3088	0.6342
0.0872	0.5982	1
0.0889	0.6157	1
0.0892	0.3564	1
0.087	0.5633	0.5
0.0858	0.6036	1
0.0892	0.3564	1
0.0792	0.8304	1
0.0799	0.9181	1
0.0797	0.9167	0.5
0.0793	0.4764	0.5
0.0805	0.8155	1
0.0262	0.6473	1
0.0827	0.9882	1
0.0889	0.4835	1
0.0201	0.3079	1
0.0853	0.5215	1
0.0809	0.3816	1
0.0842	0.9899	1
0.0807	0.6381	1
0.084	0.8301	1
0.0845	0.3806	0.5
0.1757	0.9449	1
0.0842	0.5933	1
0.0828	0.4834	1
0.0818	0.5316	1
0.0792	0.7213	1
0.0946	0.3169	1
0.0792	0.7213	1
0.0894	0.4348	1
0.0945	0.5719	1
0.0894	0.4128	1
0.1628	0.7537	1
0.0838	0.6225	1
0.0789	0.4704	1
0.0819	0.909	1
0.0755	0.3967	1
0.0796	0.4734	1
0.0801	0.8899	1
0.0815	0.5729	1
0.0913	0.2596	1
0.0939	0.2594	1
0.0793	0.9515	0.5
0.0904	0.2583	0.9996
0.0849	0.2567	1
0.107155	1	1
0.0477	0.3248	1
0.0697	0.3969	1
0.088	0.7336	1
0.0812	0.9572	1
0.08	0.8002	0.5
0.0845	0.9895	1
0.185	0.7433	1
0.1598	0.5534	0.5
0.0821	0.5934	1
0.0933	0.4611	1
0.0856	0.6187	1
0.0813	0.5279	1
0.0838	0.6225	1
0.0858	0.5131	1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

2 literature references were collected for this gene.

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Gene identifier	ML1323 (Mycobacterium leprae), probable proteasome (alpha subunit) PrcA

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