Detailed information for compound 1821761

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 359.421 | Formula: C22H21N3O2
  • H donors: 2 H acceptors: 3 LogP: 3.14 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#CC1(CCN(CC1)CC(=O)c1c[nH]c2c1cc(O)cc2)c1ccccc1
  • InChi: 1S/C22H21N3O2/c23-15-22(16-4-2-1-3-5-16)8-10-25(11-9-22)14-21(27)19-13-24-20-7-6-17(26)12-18(19)20/h1-7,12-13,24,26H,8-11,14H2
  • InChiKey: JELZFJBDSOXQGX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni smad 0.0033 0.0081 0.0131
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0097 0.0561 0.3785
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0367 0.2576 0.7511
Schistosoma mansoni thyroid hormone receptor 0.0135 0.0842 0.136
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0137 0.0221
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0004 0.0018
Schistosoma mansoni microtubule-associated protein tau 0.0659 0.4762 0.7694
Toxoplasma gondii hypothetical protein 0.0071 0.0365 0.4693
Trichomonas vaginalis bromodomain-containing protein, putative 0.0097 0.0561 0.3785
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0132 0.0819 0.1323
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), mitochondrial 0.0071 0.0365 0.1539
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0087 0.0486 0.2047
Schistosoma mansoni zinc finger protein 0.0026 0.0031 0.005
Onchocerca volvulus Putative fad oxidoreductase 0.0071 0.0365 0.2238
Trypanosoma brucei hypothetical protein, conserved 0.0033 0.0084 0.0353
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0193 0.0812
Mycobacterium tuberculosis Conserved protein 0.0033 0.0084 0.0148
Entamoeba histolytica hypothetical protein 0.0034 0.0093 0.1907
Brugia malayi acetyltransferase, GNAT family protein 0.0325 0.2263 0.6596
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0028 0.0043 0.007
Schistosoma mansoni d-amino acid oxidase 0.085 0.6189 1
Echinococcus multilocularis tar DNA binding protein 0.0132 0.0819 0.0819
Plasmodium falciparum phd finger protein, putative 0.0032 0.0073 0.0943
Echinococcus granulosus smad 0.0033 0.0081 0.0081
Echinococcus granulosus dna polymerase eta 0.0023 0.0004 0.0004
Entamoeba histolytica hypothetical protein 0.0034 0.0093 0.1907
Echinococcus granulosus histone acetyltransferase KAT2B 0.0097 0.0561 0.0561
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0084 0.0353
Echinococcus granulosus PHD finger protein rhinoceros 0.0032 0.0073 0.0073
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0023 0.0004 0.0007
Loa Loa (eye worm) hypothetical protein 0.0126 0.0779 0.1258
Mycobacterium tuberculosis Probable esterase LipL 0.0033 0.0084 0.0148
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0004 0.0018
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0125 0.0767 0.0767
Loa Loa (eye worm) hypothetical protein 0.0033 0.0084 0.0135
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.034 0.2375 1
Schistosoma mansoni hypothetical protein 0.0116 0.0703 0.1136
Mycobacterium tuberculosis Conserved hypothetical protein 0.0023 0.0004 0.0008
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0023 0.0004 0.0018
Echinococcus granulosus microtubule associated protein 2 0.0659 0.4762 0.4762
Echinococcus multilocularis Smad4 0.0033 0.0081 0.0081
Mycobacterium leprae Possible thiamine biosynthesis oxidoreductase ThiO 0.0071 0.0365 0.0461
Trypanosoma brucei DNA polymerase eta, putative 0.0023 0.0004 0.0018
Echinococcus granulosus zinc finger protein 0.0026 0.0031 0.0031
Plasmodium falciparum ataxin-2 like protein, putative 0.0126 0.0779 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.0084 0.0135
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0087 0.0486 0.0786
Trypanosoma cruzi hypothetical protein, conserved 0.0033 0.0084 0.0353
Schistosoma mansoni hypothetical protein 0.0057 0.0259 0.0418
Plasmodium falciparum histone acetyltransferase GCN5 0.0087 0.0486 0.6236
Brugia malayi beta-lactamase family protein 0.0033 0.0084 0.0244
Echinococcus granulosus tar DNA binding protein 0.0132 0.0819 0.0819
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0043 0.007
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0087 0.0486 0.0486
Schistosoma mansoni hypothetical protein 0.0116 0.0703 0.1136
Schistosoma mansoni hypothetical protein 0.0032 0.0073 0.0119
Trichomonas vaginalis CAMK family protein kinase 0.0087 0.0486 0.328
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0116 0.0703 0.0703
Echinococcus multilocularis PHD finger protein rhinoceros 0.0032 0.0073 0.0073
Mycobacterium tuberculosis Probable D-amino acid oxidase Aao 0.0779 0.566 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0033 0.0084 0.0565
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0004 0.0018
Leishmania major hypothetical protein, conserved 0.0071 0.0365 0.1539
Loa Loa (eye worm) hypothetical protein 0.0046 0.0178 0.0288
Brugia malayi jmjC domain containing protein 0.0104 0.0614 0.179
Schistosoma mansoni smad1 5 8 and 0.0033 0.0081 0.0131
Schistosoma mansoni ATP:guanidino kinase (Smc74) 0.0071 0.0365 0.0591
Leishmania major DNA polymerase eta, putative 0.0023 0.0004 0.0018
Echinococcus multilocularis GPCR, family 2 0.0116 0.0703 0.0703
Onchocerca volvulus 0.0033 0.0084 0.0281
Trichomonas vaginalis CAMK family protein kinase 0.0087 0.0486 0.328
Loa Loa (eye worm) bromodomain containing protein 0.0024 0.0018 0.0029
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0161 0.1038 0.4369
Echinococcus multilocularis peregrin 0.0042 0.0149 0.0149
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0097 0.0561 0.7205
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0004 0.0018
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0048 0.0193 0.0812
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase 0.0071 0.0365 0.0591
Trichomonas vaginalis penicillin-binding protein, putative 0.0033 0.0084 0.0565
Loa Loa (eye worm) jmjC domain-containing protein 0.0066 0.0326 0.0527
Mycobacterium ulcerans esterase/lipase LipP 0.0033 0.0084 0.0135
Onchocerca volvulus Alhambra homolog 0.0032 0.0073 0.0209
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0125 0.0767 0.0767
Loa Loa (eye worm) hypothetical protein 0.0071 0.0365 0.0591
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0004 0.0018
Trichomonas vaginalis DNA polymerase eta, putative 0.0023 0.0004 0.0029
Schistosoma mansoni survival motor neuron protein 0.0046 0.0182 0.0293
Schistosoma mansoni hypothetical protein 0.0034 0.0093 0.015
Schistosoma mansoni DNA polymerase eta 0.0023 0.0004 0.0007
Plasmodium vivax ataxin-2 like protein, putative 0.0126 0.0779 1
Loa Loa (eye worm) hypothetical protein 0.0199 0.1324 0.2139
Mycobacterium tuberculosis Probable lipase LipD 0.0033 0.0084 0.0148
Leishmania major glycerol-3-phosphate dehydrogenase-like protein 0.0071 0.0365 0.1539
Toxoplasma gondii ABC1 family protein 0.0033 0.0084 0.1076
Echinococcus multilocularis smad 0.0033 0.0081 0.0081
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0116 0.0703 0.0703
Treponema pallidum exodeoxyribonuclease (exoA) 0.0022 0 0.5
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0325 0.2263 0.3656
Giardia lamblia Kinase, PLK 0.0087 0.0486 1
Brugia malayi beta-lactamase family protein 0.0033 0.0084 0.0244
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0104 0.0614 0.0614
Brugia malayi latrophilin 2 splice variant baaae 0.0251 0.1709 0.4983
Echinococcus granulosus peregrin 0.0042 0.0149 0.0149
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0023 0.0004 0.0004
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0033 0.0081 0.0081
Loa Loa (eye worm) RNA binding protein 0.0132 0.0819 0.1323
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0137 0.0221
Trypanosoma brucei PAB1-binding protein , putative 0.0126 0.0779 0.3279
Schistosoma mansoni serine/threonine protein kinase 0.0087 0.0486 0.0786
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0116 0.0703 0.0703
Giardia lamblia PHD finger protein 15 0.0032 0.0073 0.151
Plasmodium vivax FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0071 0.0365 0.4693
Brugia malayi Pre-SET motif family protein 0.0028 0.0043 0.0127
Onchocerca volvulus Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial homolog 0.0071 0.0365 0.2238
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0819 0.1323
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0033 0.0084 0.0148
Loa Loa (eye worm) hypothetical protein 0.0066 0.0328 0.0529
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0071 0.0365 0.1539
Echinococcus granulosus mothers against decapentaplegic 5 0.0033 0.0081 0.0081
Trichomonas vaginalis set domain proteins, putative 0.022 0.1482 1
Echinococcus multilocularis tumor protein p63 0.136 1 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0033 0.0084 0.0135
Echinococcus multilocularis survival motor neuron protein 1 0.0227 0.1531 0.1531
Loa Loa (eye worm) hypothetical protein 0.0033 0.0084 0.0135
Brugia malayi MH1 domain containing protein 0.0033 0.0081 0.0236
Loa Loa (eye worm) MH2 domain-containing protein 0.0033 0.0081 0.0131
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0022 0 0.5
Schistosoma mansoni transcription factor LCR-F1 0.0034 0.0093 0.015
Trypanosoma cruzi polo-like protein kinase, putative 0.0087 0.0486 0.2047
Trypanosoma cruzi PAB1-binding protein , putative 0.0126 0.0779 0.3279
Schistosoma mansoni hypothetical protein 0.0116 0.0703 0.1136
Loa Loa (eye worm) hypothetical protein 0.0023 0.0004 0.0007
Echinococcus multilocularis thyroid hormone receptor alpha 0.0135 0.0842 0.0842
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0004 0.0018
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0044 0.0162 0.0262
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.0084 0.0565
Brugia malayi hypothetical protein 0.0034 0.0093 0.027
Loa Loa (eye worm) hypothetical protein 0.0367 0.2576 0.4162
Trypanosoma brucei glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0071 0.0365 0.1539
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0044 0.0162 0.0262
Entamoeba histolytica NAD(FAD)-dependent dehydrogenase, putative 0.0071 0.0365 0.7516
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.0084 0.0565
Brugia malayi MH1 domain containing protein 0.0033 0.0081 0.0236
Trichomonas vaginalis D-aminoacylase, putative 0.0033 0.0084 0.0565
Brugia malayi jmjC domain containing protein 0.004 0.0137 0.0399
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.034 0.2375 1
Trichomonas vaginalis CAMK family protein kinase 0.0043 0.0158 0.1065
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0004 0.0018
Mycobacterium ulcerans lipase LipD 0.0033 0.0084 0.0135
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0033 0.0084 0.0244
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0004 0.0018
Mycobacterium tuberculosis Possible thiamine biosynthesis oxidoreductase ThiO 0.0071 0.0365 0.0646
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0004 0.0018
Echinococcus multilocularis zinc finger protein 0.0026 0.0031 0.0031
Brugia malayi beta-lactamase 0.0033 0.0084 0.0244
Leishmania major hypothetical protein, conserved 0.0126 0.0779 0.3279
Brugia malayi hypothetical protein 0.0126 0.0779 0.2271
Entamoeba histolytica hypothetical protein 0.0034 0.0093 0.1907
Brugia malayi cDNA sequence BC016226 0.0071 0.0365 0.1065
Loa Loa (eye worm) latrophilin receptor protein 2 0.0116 0.0703 0.1136
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0034 0.0093 0.0093
Brugia malayi MH2 domain containing protein 0.0481 0.343 1
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0058 0.0271 0.1141
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0033 0.0084 0.0148
Echinococcus multilocularis glycerol 3 phosphate dehydrogenase 0.0071 0.0365 0.0365
Schistosoma mansoni bromodomain containing protein 0.0067 0.0335 0.0541
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0073 0.0943
Onchocerca volvulus 0.022 0.1482 1
Brugia malayi Bromodomain containing protein 0.0042 0.0149 0.0434
Echinococcus granulosus survival motor neuron protein 1 0.0227 0.1531 0.1531
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0023 0.0004 0.0029
Onchocerca volvulus 0.0199 0.1324 0.8896
Trypanosoma brucei FAD dependent oxidoreductase, putative 0.0071 0.0365 0.1539
Plasmodium vivax SET domain protein, putative 0.0028 0.0043 0.0557
Mycobacterium ulcerans glycerol-3-phosphate dehydrogenase GlpD2 0.0071 0.0365 0.0591
Loa Loa (eye worm) hypothetical protein 0.0116 0.0703 0.1136
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0819 0.1323
Mycobacterium ulcerans beta-lactamase 0.0033 0.0084 0.0135
Giardia lamblia Histone acetyltransferase GCN5 0.0087 0.0486 0.9987
Chlamydia trachomatis D-amino acid dehydrogenase 0.0071 0.0365 0.5
Loa Loa (eye worm) hypothetical protein 0.0044 0.0162 0.0262
Echinococcus granulosus FAD dependent oxidoreductase domain containing protein 0.0071 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0251 0.1709 0.2762
Mycobacterium tuberculosis Conserved protein 0.0033 0.0084 0.0148
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0116 0.0703 0.2049
Echinococcus granulosus Smad4 0.0033 0.0081 0.0081
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0032 0.0073 0.0119
Trypanosoma brucei unspecified product 0.0023 0.0004 0.0018
Mycobacterium ulcerans thiamine biosynthesis oxidoreductase ThiO 0.0071 0.0365 0.0591
Echinococcus granulosus histone lysine methyltransferase setb 0.0044 0.0162 0.0162
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0028 0.0043 0.0043
Schistosoma mansoni glycerol-3-phosphate dehydrogenase 0.0071 0.0365 0.0591
Echinococcus granulosus jumonji domain containing protein 0.0044 0.0166 0.0166
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0033 0.0084 0.0148
Brugia malayi PHD-finger family protein 0.0032 0.0073 0.0214
Loa Loa (eye worm) Smad1 0.0033 0.0081 0.0131
Mycobacterium ulcerans hypothetical protein 0.0179 0.1173 0.1896
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0063 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.0036 0.0103 0.0166
Loa Loa (eye worm) transcription factor SMAD2 0.0481 0.343 0.5542
Schistosoma mansoni smad1 5 8 and 0.0033 0.0081 0.0131
Mycobacterium tuberculosis Probable lipase LipE 0.0033 0.0084 0.0148
Echinococcus multilocularis FAD dependent oxidoreductase domain containing protein 0.0071 0.0365 0.0365
Loa Loa (eye worm) hypothetical protein 0.0054 0.0243 0.0393
Echinococcus multilocularis mothers against decapentaplegic 5 0.0033 0.0081 0.0081
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0063 0.031 0.031
Loa Loa (eye worm) MH2 domain-containing protein 0.0481 0.343 0.5542
Echinococcus granulosus beta LACTamase domain containing family member 0.0033 0.0084 0.0084
Loa Loa (eye worm) beta-lactamase 0.0033 0.0084 0.0135
Entamoeba histolytica anaerobic glycerol-3-phosphate dehydrogenase subunit A, putative 0.0071 0.0365 0.7516
Loa Loa (eye worm) hypothetical protein 0.085 0.6189 1
Brugia malayi hypothetical protein 0.0227 0.1531 0.4463
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0033 0.0084 0.0135
Schistosoma mansoni fad oxidoreductase 0.0071 0.0365 0.0591
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0819 0.1323
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase, putative 0.0071 0.0365 0.1539
Entamoeba histolytica hypothetical protein 0.0034 0.0093 0.1907
Toxoplasma gondii FAD-dependent glycerol-3-phosphate dehydrogenase 0.0071 0.0365 0.4693
Trypanosoma cruzi L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0071 0.0365 0.1539
Trypanosoma brucei L-2-hydroxyglutarate dehydrogenase, mitochondrial, putative 0.0071 0.0365 0.1539
Trichomonas vaginalis esterase, putative 0.0033 0.0084 0.0565
Echinococcus multilocularis microtubule associated protein 2 0.0659 0.4762 0.4762
Brugia malayi pyruvate dehydrogenase phosphatase regulatory subunit precursor 0.0071 0.0365 0.1065
Trypanosoma brucei DNA polymerase IV, putative 0.0023 0.0004 0.0018
Onchocerca volvulus 0.0046 0.0182 0.096
Mycobacterium tuberculosis Conserved hypothetical protein 0.0179 0.1173 0.2073
Entamoeba histolytica acetyltransferase, GNAT family 0.0087 0.0486 0.9987
Trichomonas vaginalis CAMK family protein kinase 0.0087 0.0486 0.328
Trypanosoma brucei mitochondrial DNA polymerase beta 0.034 0.2375 1
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0161 0.1038 0.4369
Toxoplasma gondii PHD-finger domain-containing protein 0.0032 0.0073 0.0943
Brugia malayi hypothetical protein 0.0081 0.0445 0.1296
Loa Loa (eye worm) hypothetical protein 0.0071 0.0365 0.0591
Schistosoma mansoni hypothetical protein 0.0046 0.0182 0.0293
Brugia malayi dimethylglycine dehydrogenase, mitochondrial precursor, putative 0.0071 0.0365 0.1065
Brugia malayi RE18450p 0.0071 0.0365 0.1065
Brugia malayi RNA binding protein 0.0132 0.0819 0.2387
Plasmodium falciparum FAD-dependent glycerol-3-phosphate dehydrogenase, putative 0.0071 0.0365 0.4693
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0046 0.0182 0.0529
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0023 0.0004 0.0004
Loa Loa (eye worm) TAR-binding protein 0.0132 0.0819 0.1323
Loa Loa (eye worm) glycerol-3-phosphate dehydrogenase 0.0071 0.0365 0.0591
Schistosoma mansoni cellular tumor antigen P53 0.0199 0.1324 0.2139
Plasmodium vivax hypothetical protein, conserved 0.0032 0.0073 0.0943
Schistosoma mansoni smad1 5 8 and 0.0033 0.0081 0.0131
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0034 0.0093 0.0093
Plasmodium vivax hypothetical protein, conserved 0.0033 0.0084 0.1076
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0057 0.0259 0.0259
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0819 0.1323
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0004 0.0018
Schistosoma mansoni tar DNA-binding protein 0.0132 0.0819 0.1323
Onchocerca volvulus Dimethylglycine dehydrogenase, mitochondrial homolog 0.0071 0.0365 0.2238
Schistosoma mansoni kinase 0.0044 0.0166 0.0269
Echinococcus multilocularis jumonji domain containing protein 0.0044 0.0166 0.0166
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0004 0.0018
Leishmania major hypothetical protein, conserved 0.0071 0.0365 0.1539
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0048 0.0193 0.0812
Trichomonas vaginalis CAMK family protein kinase 0.0043 0.0158 0.1065
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0044 0.0162 0.0162
Schistosoma mansoni Smad4 0.0033 0.0081 0.0131
Loa Loa (eye worm) hypothetical protein 0.0033 0.0084 0.0135
Mycobacterium tuberculosis Conserved protein 0.0033 0.0084 0.0148
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0028 0.0043 0.0557
Loa Loa (eye worm) acetyltransferase 0.0325 0.2263 0.3656
Brugia malayi MH2 domain containing protein 0.0033 0.0081 0.0236
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0004 0.0013
Loa Loa (eye worm) MH1 domain-containing protein 0.0033 0.0081 0.0131
Entamoeba histolytica serine/threonine protein kinase, putative 0.0087 0.0486 1
Onchocerca volvulus 0.0033 0.0084 0.0281
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0033 0.0081 0.0131
Mycobacterium ulcerans D-amino acid oxidase Aao 0.0071 0.0365 0.0591
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0004 0.0018
Brugia malayi Smad1 0.0033 0.0081 0.0236
Schistosoma mansoni NAD dehydrogenase 0.0071 0.0365 0.0591
Trichomonas vaginalis CAMK family protein kinase 0.0087 0.0486 0.328
Brugia malayi Pre-SET motif family protein 0.0194 0.1283 0.3739
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0161 0.1038 0.4369
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0033 0.0084 0.0135
Schistosoma mansoni jumonji domain containing protein 0.0083 0.0454 0.0734
Echinococcus multilocularis dna polymerase eta 0.0023 0.0004 0.0004
Mycobacterium leprae Probable cholesterol oxidase precursor ChoD (cholesterol-O2 oxidoreductase) 0.0071 0.0365 0.0461
Loa Loa (eye worm) hypothetical protein 0.0032 0.0073 0.0119
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0057 0.0259 0.0259
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0104 0.0614 0.0614
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0116 0.0703 0.0703
Echinococcus multilocularis dna polymerase kappa 0.0023 0.0004 0.0004
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.0036 0.0036
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0004 0.0007
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0033 0.0086 0.0086
Trypanosoma brucei polo-like protein kinase 0.0087 0.0486 0.2047
Echinococcus granulosus glycerol 3 phosphate dehydrogenase 0.0071 0.0365 0.0365
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0004 0.0018
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0023 0.0004 0.0007
Echinococcus granulosus GPCR family 2 0.0116 0.0703 0.0703
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0137 0.0221
Entamoeba histolytica deoxycytidyl transferase, putative 0.0023 0.0004 0.0088
Trichomonas vaginalis CAMK family protein kinase 0.0087 0.0486 0.328
Schistosoma mansoni terminal deoxycytidyl transferase 0.0023 0.0004 0.0007
Leishmania major mitochondrial DNA polymerase beta 0.034 0.2375 1
Echinococcus granulosus dna polymerase kappa 0.0023 0.0004 0.0004
Trypanosoma cruzi DNA polymerase kappa, putative 0.0023 0.0004 0.0018
Brugia malayi PHD-finger family protein 0.0031 0.0068 0.0199
Schistosoma mansoni hypothetical protein 0.0251 0.1709 0.2762
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0137 0.0137
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0071 0.0365 0.1539
Echinococcus granulosus histone acetyltransferase KAT2B 0.0313 0.2178 0.2178
Echinococcus multilocularis beta LACTamase domain containing family member 0.0033 0.0084 0.0084
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0004 0.0018
Loa Loa (eye worm) hypothetical protein 0.0227 0.1531 0.2473
Trypanosoma cruzi PAB1-binding protein , putative 0.0126 0.0779 0.3279
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0325 0.2263 0.2263
Giardia lamblia DINP protein human, muc B family 0.0023 0.0004 0.0088
Schistosoma mansoni fad oxidoreductase 0.0071 0.0365 0.0591
Loa Loa (eye worm) hypothetical protein 0.0048 0.0191 0.0309
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0087 0.0486 0.0486
Brugia malayi Calcitonin receptor-like protein seb-1 0.0367 0.2576 0.7511
Echinococcus multilocularis lysine specific demethylase 5A 0.0038 0.0123 0.0123
Brugia malayi MH2 domain containing protein 0.0033 0.0081 0.0236
Schistosoma mansoni hypothetical protein 0.0125 0.0767 0.1239
Brugia malayi TAR-binding protein 0.0132 0.0819 0.2387
Leishmania major DNA polymerase kappa, putative 0.0023 0.0004 0.0018
Giardia lamblia Glycerol-3-phosphate dehydrogenase 0.0071 0.0365 0.7516
Leishmania major hypothetical protein, conserved 0.0033 0.0084 0.0353
Loa Loa (eye worm) PHD-finger family protein 0.0032 0.0073 0.0119
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0367 0.2576 0.4162
Mycobacterium ulcerans DNA polymerase IV 0.0023 0.0004 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.0087 0.0486 0.328
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0023 0.0004 0.0008
Trichomonas vaginalis CAMK family protein kinase 0.0087 0.0486 0.328
Mycobacterium ulcerans D-amino acid oxidase Aao 0.085 0.6189 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0097 0.0561 0.7205
Schistosoma mansoni hypothetical protein 0.0116 0.0703 0.1136
Trypanosoma cruzi polo-like protein kinase, putative 0.0087 0.0486 0.2047
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0097 0.0561 0.7205
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0033 0.0084 0.0135
Trypanosoma cruzi Present in the outer mitochondrial membrane proteome 20 0.0071 0.0365 0.1539
Loa Loa (eye worm) hypothetical protein 0.0033 0.0084 0.0135
Brugia malayi Bromodomain containing protein 0.0078 0.0416 0.1214
Brugia malayi RNA recognition motif domain containing protein 0.0132 0.0819 0.2387
Mycobacterium tuberculosis Probable hydrolase 0.0033 0.0084 0.0148
Mycobacterium ulcerans hypothetical protein 0.0033 0.0084 0.0135
Brugia malayi Latrophilin receptor protein 2 0.0116 0.0703 0.2049
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0194 0.1283 0.2072
Brugia malayi serine/threonine-protein kinase plk-2 0.0087 0.0486 0.1418
Mycobacterium leprae PROBABLE D-AMINO ACID OXIDASE AAO 0.085 0.6189 1
Toxoplasma gondii LsmAD domain-containing protein 0.0126 0.0779 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0033 0.0086 0.0086
Brugia malayi Bromodomain containing protein 0.0044 0.0161 0.047
Trypanosoma brucei DNA polymerase kappa, putative 0.0023 0.0004 0.0018
Loa Loa (eye worm) hypothetical protein 0.0071 0.0365 0.0591
Trypanosoma cruzi glycerol-3-phosphate dehydrogenase (FAD-dependent), putative 0.0071 0.0365 0.1539
Trypanosoma brucei electron transfer flavoprotein-ubiquinone oxidoreductase, putative 0.0071 0.0365 0.1539
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0048 0.0193 0.0812
Loa Loa (eye worm) hypothetical protein 0.0033 0.0084 0.0135
Brugia malayi ImpB/MucB/SamB family protein 0.0023 0.0004 0.0013
Onchocerca volvulus 0.0033 0.0084 0.0281
Schistosoma mansoni thyroid hormone receptor 0.0135 0.0842 0.136
Onchocerca volvulus Serine\/threonine kinase homolog 0.0087 0.0486 0.3077
Plasmodium falciparum ataxin-2 like protein, putative 0.0126 0.0779 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0212 0.142 0.2508
Trypanosoma cruzi FAD dependent oxidoreductase, putative 0.0071 0.0365 0.1539
Echinococcus granulosus TGF beta signal transducer SmadC 0.0033 0.0081 0.0081
Trypanosoma cruzi DNA polymerase eta, putative 0.0023 0.0004 0.0018
Toxoplasma gondii hypothetical protein 0.0055 0.0245 0.3152

Activities

Activity type Activity value Assay description Source Reference
Inhibition (binding) = 16 % Displacement of [3H]ifenprodil from Wistar rat cerebral cortex glutamate NMDA receptor GluN2B subunit at 10 uM after 120 mins by scintillation counting analysis ChEMBL. 24290063

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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