Detailed information for compound 1845996

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1102.23 | Formula: C53H79N7O18
  • H donors: 14 H acceptors: 16 LogP: 1.65 Rotable bonds: 21
    Rule of 5 violations (Lipinski): 4
  • SMILES: CCCCCCCCCCOCCOc1ccc(cc1)C(=O)N[C@H]1C[C@@H](O)[C@@H](O)NC(=O)[C@@H]2[C@@H](O)[C@H](CN2C(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]2N(C(=O)[C@@H](NC1=O)[C@H](O)C)C[C@@H](C2)O)[C@@H]([C@H](c1ccc(cc1)O)O)O)[C@H](O)C)C
  • InChi: 1S/C53H79N7O18/c1-5-6-7-8-9-10-11-12-21-77-22-23-78-35-19-15-32(16-20-35)46(69)54-36-25-38(65)49(72)58-51(74)42-43(66)28(2)26-60(42)53(76)40(30(4)62)56-50(73)41(45(68)44(67)31-13-17-33(63)18-14-31)57-48(71)37-24-34(64)27-59(37)52(75)39(29(3)61)55-47(36)70/h13-20,28-30,34,36-45,49,61-68,72H,5-12,21-27H2,1-4H3,(H,54,69)(H,55,70)(H,56,73)(H,57,71)(H,58,74)/t28-,29+,30+,34+,36-,37-,38+,39-,40-,41-,42-,43-,44-,45-,49+/m0/s1
  • InChiKey: ZRNIVDVKZGKZEJ-XMHUMVPLSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cathepsin L-like precursor 0.0307 0.2813 0.4577
Brugia malayi Cathepsin L-like precursor 0.0307 0.2813 0.4577
Entamoeba histolytica cysteine proteinase, putative 0.0307 0.2813 0.4613
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Echinococcus granulosus cathepsin L cysteine protease 0.0167 0.1454 0.1422
Schistosoma mansoni cathepsin S (C01 family) 0.0071 0.0528 0.0809
Trypanosoma cruzi cruzipain precursor, putative 0.0307 0.2813 0.4611
Plasmodium falciparum serine repeat antigen 4 0.0071 0.0528 0.0809
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0528 0.0866
Schistosoma mansoni intermediate filament proteins 0.0022 0.0048 0.0017
Brugia malayi Cathepsin L-like precursor 0.0212 0.1887 0.305
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0307 0.2813 0.4579
Entamoeba histolytica cysteine protease, putative 0.0167 0.1454 0.2385
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0095 0.0058
Trichomonas vaginalis bromodomain-containing protein, putative 0.0034 0.0169 0.0277
Schistosoma mansoni SmCB2 peptidase (C01 family) 0.0647 0.6101 1
Trypanosoma cruzi major cysteine proteinase, putative 0.0071 0.0528 0.0866
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0032 0.0146 0.0108
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0307 0.2813 0.4613
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0307 0.2813 0.4613
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.0528 0.0866
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0307 0.2813 0.4613
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0646 0.6098 0.9995
Schistosoma mansoni hypothetical protein 0.0027 0.0095 0.0095
Giardia lamblia Cathepsin B precursor 0.0071 0.0528 0.1832
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0307 0.2813 0.2786
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.004 0.0005
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0307 0.2813 0.4579
Giardia lamblia Cysteine protease 0.0071 0.0528 0.1832
Schistosoma mansoni hypothetical protein 0.0021 0.004 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0087 0.0143
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0307 0.2813 0.4613
Entamoeba histolytica cysteine protease, putative 0.0167 0.1454 0.2385
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0027 0.0095 0.0095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0307 0.2813 0.4579
Entamoeba histolytica cysteine protease, putative 0.0071 0.0528 0.0866
Mycobacterium tuberculosis Probable lipase LipE 0.0026 0.0087 0.0337
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0167 0.1454 0.2337
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0095 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0212 0.1887 0.3094
Plasmodium vivax serine-repeat antigen 4 (SERA), putative 0.0071 0.0528 0.0809
Entamoeba histolytica cysteine protease, putative 0.0167 0.1454 0.2385
Plasmodium vivax unspecified product 0.0071 0.0528 0.0809
Loa Loa (eye worm) hypothetical protein 0.0026 0.0087 0.0082
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0071 0.0528 0.0809
Loa Loa (eye worm) CYP4Cod1 0.0021 0.004 0.0005
Schistosoma mansoni hypothetical protein 0.0027 0.0095 0.0095
Echinococcus granulosus neuropeptide receptor 0.0027 0.0095 0.0058
Schistosoma mansoni opsin-like receptor 0.0027 0.0095 0.0095
Brugia malayi beta-lactamase 0.0026 0.0087 0.0082
Giardia lamblia Cathepsin B precursor 0.0249 0.2252 1
Brugia malayi ubiquitin conjugating enzyme protein 13 0.0646 0.6098 0.9995
Giardia lamblia Cathepsin L precursor 0.0071 0.0528 0.1832
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0026 0.0087 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0027 0.0095 0.0095
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0027 0.0095 0.0095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0095 0.0095
Echinococcus multilocularis sex peptide receptor 0.0027 0.0095 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0307 0.2813 0.4613
Echinococcus multilocularis neuropeptide Y receptor 0.0027 0.0095 0.0058
Echinococcus multilocularis cathepsin b 0.0647 0.6101 0.6086
Plasmodium falciparum dipeptidyl aminopeptidase 1 0.0071 0.0528 0.0809
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0027 0.0095 0.0058
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0027 0.0095 0.0095
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.004 0.0066
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0212 0.1887 0.3092
Plasmodium vivax serine-repeat antigen 3 (SERA) 0.0071 0.0528 0.0809
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0027 0.0095 0.0058
Loa Loa (eye worm) TYRA-2 protein 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Schistosoma mansoni lamin 0.0022 0.0048 0.0017
Schistosoma mansoni neuropeptide receptor 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Echinococcus granulosus sex peptide receptor 0.0027 0.0095 0.0058
Entamoeba histolytica cysteine proteinase 1, putative 0.0167 0.1454 0.2385
Onchocerca volvulus 0.0027 0.0095 0.0172
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0095 0.0095
Entamoeba histolytica cysteine protease, putative 0.0167 0.1454 0.2385
Echinococcus granulosus serotonin receptor 0.0027 0.0095 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0307 0.2813 0.4613
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0307 0.2813 0.4613
Echinococcus multilocularis snurportin 1 0.0219 0.1962 0.1932
Echinococcus multilocularis lamin dm0 0.0022 0.0048 0.001
Brugia malayi hypothetical protein 0.0027 0.0095 0.0095
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0026 0.0087 0.0082
Schistosoma mansoni P2X receptor subunit 0.0417 0.3875 0.6329
Echinococcus multilocularis neuropeptide receptor A26 0.0027 0.0095 0.0058
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0095 0.0058
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0027 0.0095 0.0095
Brugia malayi Dopamine receptor protein 2 0.0027 0.0095 0.0095
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0026 0.0087 0.0082
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0307 0.2813 0.4613
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0071 0.0528 0.0809
Trypanosoma cruzi cysteine peptidase, putative 0.0307 0.2813 0.4611
Brugia malayi Probable 3',5'-cyclic phosphodiesterase R153.1, putative 0.0028 0.0108 0.0116
Brugia malayi Cathepsin L-like precursor 0.0307 0.2813 0.4577
Giardia lamblia Hypothetical protein 0.0071 0.0528 0.1832
Echinococcus multilocularis cathepsin b 0.0647 0.6101 0.6086
Onchocerca volvulus 0.0027 0.0095 0.0172
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.0095 0.0058
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0095 0.0058
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0647 0.6101 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0034 0.0169 0.0217
Schistosoma mansoni biogenic amine receptor 0.0027 0.0095 0.0095
Plasmodium falciparum histone acetyltransferase GCN5 0.0031 0.0142 0.0172
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.0095 0.0095
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0027 0.0095 0.0095
Echinococcus multilocularis orexin receptor type 2 0.0027 0.0095 0.0058
Giardia lamblia Cathepsin L precursor 0.0071 0.0528 0.1832
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0307 0.2813 0.4579
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0071 0.0528 0.0866
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.0095 0.0095
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0028 0.0108 0.0071
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0027 0.0095 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0307 0.2813 0.4613
Loa Loa (eye worm) intermediate filament protein 0.0022 0.0048 0.0017
Schistosoma mansoni neuropeptide receptor 0.0027 0.0095 0.0095
Entamoeba histolytica cysteine protease, putative 0.0167 0.1454 0.2385
Plasmodium falciparum ubiquitin-conjugating enzyme E2 N, putative 0.0646 0.6098 1
Onchocerca volvulus 0.0027 0.0095 0.0172
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0307 0.2813 0.4613
Leishmania major cathepsin L-like protease 0.0307 0.2813 0.4613
Leishmania major ubiquitin-conjugating enzyme e2, putative 0.0646 0.6098 1
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0071 0.0528 0.0809
Loa Loa (eye worm) hypothetical protein 0.0026 0.0087 0.0082
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0528 0.0866
Schistosoma mansoni cathepsin C 0.0071 0.0528 0.0809
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0307 0.2813 0.4577
Plasmodium vivax ubiquitin-conjugating enzyme E2 N, putative 0.0646 0.6098 1
Entamoeba histolytica cysteine proteinase, putative 0.0212 0.1887 0.3094
Leishmania major hypothetical protein, conserved 0.0026 0.0087 0.0143
Trypanosoma cruzi hypothetical protein, conserved 0.0026 0.0087 0.0143
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0027 0.0095 0.0095
Schistosoma mansoni biogenic amine (5HT) receptor 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0087 0.0082
Trypanosoma cruzi cytochrome p450-like protein, putative 0.0021 0.004 0.0066
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0646 0.6098 0.9995
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0095 0.0058
Schistosoma mansoni cathepsin s 0.0096 0.0765 0.12
Echinococcus granulosus g-protein coupled receptor 0.0027 0.0095 0.0058
Echinococcus multilocularis neuropeptide receptor 0.0027 0.0095 0.0058
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0071 0.0528 0.0809
Schistosoma mansoni hypothetical protein 0.0219 0.1962 0.3174
Trypanosoma cruzi cysteine protease, putative 0.0167 0.1454 0.2384
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0027 0.0095 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L or H-like cysteine peptidase 0.0071 0.0528 0.0866
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0096 0.0765 0.12
Loa Loa (eye worm) hypothetical protein 0.0212 0.1887 0.305
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Brugia malayi hypothetical protein 0.0027 0.0095 0.0095
Onchocerca volvulus 0.0027 0.0095 0.0172
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0307 0.2813 0.4579
Echinococcus granulosus cathepsin l1 0.0307 0.2813 0.2786
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0071 0.0528 0.0866
Echinococcus granulosus peptide allatostatin:somatostatin 0.0027 0.0095 0.0058
Schistosoma mansoni P2X receptor subunit 0.0417 0.3875 0.6329
Echinococcus multilocularis 0.0021 0.004 0.0003
Brugia malayi G-protein coupled receptor 0.0027 0.0095 0.0095
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.0095 0.0058
Echinococcus multilocularis neuropeptide FF receptor 2 0.0027 0.0095 0.0058
Loa Loa (eye worm) hypothetical protein 0.0026 0.0087 0.0082
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Mycobacterium leprae conserved hypothetical protein 0.0026 0.0087 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0026 0.0087 0.0143
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Plasmodium vivax serine-repeat antigen (SERA) 0.0071 0.0528 0.0809
Schistosoma mansoni biogenic amine receptor 0.0027 0.0095 0.0095
Echinococcus multilocularis lamin 0.0022 0.0048 0.001
Giardia lamblia Cathepsin B precursor 0.0071 0.0528 0.1832
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0032 0.0146 0.0108
Entamoeba histolytica cysteine protease, putative 0.0167 0.1454 0.2385
Echinococcus multilocularis ubiquitin conjugating enzyme E2 N 0.0646 0.6098 0.6083
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0071 0.0528 0.0809
Plasmodium falciparum serine repeat antigen 5 0.0071 0.0528 0.0809
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0071 0.0528 0.0866
Onchocerca volvulus 0.0026 0.0087 0.0142
Brugia malayi Papain family cysteine protease containing protein 0.0307 0.2813 0.4577
Echinococcus multilocularis g protein coupled receptor 0.0027 0.0095 0.0058
Brugia malayi larval opioid receptor 0.0027 0.0095 0.0095
Loa Loa (eye worm) fibroinase 0.0307 0.2813 0.4577
Brugia malayi hypothetical protein 0.0027 0.0095 0.0095
Trichomonas vaginalis D-aminoacylase, putative 0.0026 0.0087 0.0143
Echinococcus granulosus cathepsin b 0.0647 0.6101 0.6086
Echinococcus granulosus cathepsin l cysteine peptidase 0.0307 0.2813 0.2786
Echinococcus granulosus biogenic amine 5HT receptor 0.0027 0.0095 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0307 0.2813 0.4579
Giardia lamblia Cathepsin L-like protease 0.0071 0.0528 0.1832
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0528 0.0866
Schistosoma mansoni alpha-1 adrenergic receptor 0.0027 0.0095 0.0095
Echinococcus granulosus histone acetyltransferase KAT2B 0.0034 0.0169 0.0132
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Leishmania major cathepsin L-like protease 0.0307 0.2813 0.4613
Trypanosoma brucei ubiquitin-protein ligase, putative 0.0646 0.6098 1
Brugia malayi fibroinase precursor 0.0071 0.0528 0.0809
Echinococcus multilocularis neuropeptides capa receptor 0.0027 0.0095 0.0058
Onchocerca volvulus 0.0027 0.0095 0.0172
Echinococcus granulosus 7tm_1 domain containing protein 0.0027 0.0095 0.0058
Brugia malayi Ubiquitin conjugating enzyme protein 13 0.0646 0.6098 0.9995
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0307 0.2813 0.2786
Plasmodium falciparum serine repeat antigen 6 0.0071 0.0528 0.0809
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Brugia malayi Melatonin receptor type 1A 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Entamoeba histolytica acetyltransferase, GNAT family 0.0031 0.0142 0.0232
Trichomonas vaginalis D-aminoacylase, putative 0.0026 0.0087 0.0143
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0034 0.0169 0.0277
Trichomonas vaginalis Clan CA, family C1, cathepsin H-like cysteine peptidase 0.0071 0.0528 0.0866
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0071 0.0528 0.0809
Brugia malayi hypothetical protein 0.0027 0.0095 0.0095
Echinococcus granulosus g protein coupled receptor 0.0027 0.0095 0.0058
Echinococcus granulosus dro:myosuppressin receptor 0.0027 0.0095 0.0058
Schistosoma mansoni biogenic amine (5HT) receptor 0.0027 0.0095 0.0095
Brugia malayi beta-lactamase family protein 0.0026 0.0087 0.0082
Echinococcus granulosus neuropeptide Y receptor 0.0027 0.0095 0.0058
Echinococcus granulosus g protein coupled receptor 0.0027 0.0095 0.0058
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0164 0.1426 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Schistosoma mansoni biogenic amine receptor 0.0027 0.0095 0.0095
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0027 0.0095 0.0095
Giardia lamblia Cathepsin L precursor 0.0071 0.0528 0.1832
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0528 0.0866
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0027 0.0095 0.0095
Mycobacterium tuberculosis Conserved protein 0.0026 0.0087 0.0337
Toxoplasma gondii cytochrome p450 superfamily protein 0.0021 0.004 0.0005
Brugia malayi G protein-coupled receptor F59B2.13 0.0027 0.0095 0.0095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0095 0.0095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0095 0.0095
Schistosoma mansoni neuropeptide F-like receptor 0.0027 0.0095 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0307 0.2813 0.4613
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Leishmania major cathepsin L-like protease 0.0307 0.2813 0.4613
Leishmania major cathepsin L-like protease 0.0307 0.2813 0.4613
Onchocerca volvulus 0.0307 0.2813 1
Plasmodium falciparum cysteine proteinase falcipain 3 0.0307 0.2813 0.4579
Loa Loa (eye worm) hypothetical protein 0.0026 0.0087 0.0082
Trypanosoma cruzi cysteine peptidase, putative 0.0096 0.0765 0.1254
Brugia malayi hypothetical protein 0.0027 0.0095 0.0095
Echinococcus multilocularis neuropeptide s receptor 0.0027 0.0095 0.0058
Echinococcus granulosus p2X purinoceptor 4 0.0417 0.3875 0.3852
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0528 0.0866
Brugia malayi Cathepsin L-like precursor 0.0307 0.2813 0.4577
Echinococcus granulosus neuropeptide receptor 0.0027 0.0095 0.0058
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0027 0.0095 0.0095
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0027 0.0095 0.0058
Toxoplasma gondii ubiquitin-conjugating enzyme subfamily protein 0.0646 0.6098 1
Schistosoma mansoni subfamily C1A unassigned peptidase (C01 family) 0.0071 0.0528 0.0809
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0307 0.2813 0.4579
Plasmodium falciparum serine repeat antigen 3 0.0071 0.0528 0.0809
Loa Loa (eye worm) hypothetical protein 0.0071 0.0528 0.0809
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0027 0.0095 0.0095
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0219 0.1962 0.3174
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Brugia malayi cahepsin L-like non-peptiedase homolog 0.0071 0.0528 0.0809
Echinococcus multilocularis allatostatin A receptor 0.0027 0.0095 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0307 0.2813 0.4613
Entamoeba histolytica cysteine proteinase, putative 0.0167 0.1454 0.2385
Brugia malayi hypothetical protein 0.0027 0.0095 0.0095
Trichomonas vaginalis penicillin-binding protein, putative 0.0026 0.0087 0.0143
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0027 0.0095 0.0058
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.105 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0095 0.0058
Echinococcus granulosus beta LACTamase domain containing family member 0.0026 0.0087 0.005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0307 0.2813 0.4577
Onchocerca volvulus Cathepsin L homolog 0.0071 0.0528 0.1737
Echinococcus granulosus neuropeptide FF receptor 2 0.0027 0.0095 0.0058
Brugia malayi cathepsin B-like cysteine proteinase 0.0647 0.6101 1
Loa Loa (eye worm) hypothetical protein 0.0096 0.0765 0.12
Schistosoma mansoni histamine h1 receptor 0.0027 0.0095 0.0095
Mycobacterium tuberculosis Conserved protein 0.0026 0.0087 0.0337
Mycobacterium tuberculosis Probable hydrolase 0.0026 0.0087 0.0337
Echinococcus granulosus ubiquitin conjugating enzyme E2 N 0.0646 0.6098 0.6083
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0071 0.0528 0.1832
Echinococcus granulosus fmrfamide receptor 0.0027 0.0095 0.0058
Brugia malayi cathepsin L-like cysteine proteinase, identical 0.0096 0.0765 0.12
Onchocerca volvulus 0.0027 0.0095 0.0172
Onchocerca volvulus 0.0307 0.2813 1
Echinococcus granulosus intermediate filament protein 0.0022 0.0048 0.001
Brugia malayi ORL1-like opioid receptor 0.0027 0.0095 0.0095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0167 0.1454 0.2338
Loa Loa (eye worm) hypothetical protein 0.0071 0.0528 0.0809
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0071 0.0528 0.1832
Brugia malayi Cathepsin L-like precursor 0.0307 0.2813 0.4577
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0307 0.2813 0.4613
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0307 0.2813 0.4613
Entamoeba histolytica cysteine protease, putative 0.0071 0.0528 0.0866
Loa Loa (eye worm) cytochrome P450 0.0021 0.004 0.0005
Trypanosoma cruzi cruzipain precursor, putative 0.0096 0.0765 0.1254
Brugia malayi Papain family cysteine protease containing protein 0.0071 0.0528 0.0809
Schistosoma mansoni cathepsin F (C01 family) 0.0212 0.1887 0.305
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0028 0.0108 0.0071
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0095 0.0058
Echinococcus granulosus cysteine protease 0.0167 0.1454 0.1422
Giardia lamblia Cathepsin B precursor 0.0071 0.0528 0.1832
Onchocerca volvulus Cathepsin F homolog 0.0307 0.2813 1
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0167 0.1454 0.2337
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0096 0.0765 0.12
Schistosoma mansoni dipeptidyl-peptidase I (C01 family) 0.0071 0.0528 0.0809
Toxoplasma gondii preprocathepsin c precursor, putative 0.0071 0.0528 0.0809
Echinococcus multilocularis cathepsin L cysteine protease 0.0307 0.2813 0.2786
Echinococcus multilocularis g protein coupled receptor 0.0027 0.0095 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.0528 0.0866
Entamoeba histolytica cysteine proteinase, putative 0.0167 0.1454 0.2385
Trypanosoma cruzi cysteine peptidase, putative 0.0307 0.2813 0.4611
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0027 0.0095 0.0058
Trypanosoma brucei Lanosterol 14-alpha demethylase 0.0021 0.004 0.0005
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0071 0.0528 0.0809
Onchocerca volvulus 0.0307 0.2813 1
Echinococcus multilocularis p2X purinoceptor 4 0.0417 0.3875 0.3852
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0249 0.2252 0.3692
Brugia malayi hypothetical protein 0.0027 0.0095 0.0095
Onchocerca volvulus Cathepsin L homolog 0.0307 0.2813 1
Mycobacterium ulcerans hypothetical protein 0.0026 0.0087 1
Trypanosoma cruzi ubiquitin-conjugating enzyme E2, putative 0.0646 0.6098 0.9995
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0647 0.6101 1
Leishmania major cathepsin L-like protease 0.0307 0.2813 0.4613
Onchocerca volvulus 0.0027 0.0095 0.0172
Entamoeba histolytica cysteine protease, putative 0.0167 0.1454 0.2385
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0307 0.2813 0.4613
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0307 0.2813 0.4613
Plasmodium vivax dipeptidyl aminopeptidase 1, putative 0.0071 0.0528 0.0809
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0027 0.0095 0.0058
Plasmodium vivax serine-repeat antigen 2 (SERA) 0.0071 0.0528 0.0809
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0071 0.0528 0.0866
Loa Loa (eye worm) hypothetical protein 0.0071 0.0528 0.0809
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Onchocerca volvulus 0.0027 0.0095 0.0172
Brugia malayi cathepsin L-like cysteine proteinase 0.0071 0.0528 0.0809
Brugia malayi Cathepsin L-like precursor 0.0307 0.2813 0.4577
Plasmodium falciparum dipeptidyl aminopeptidase 2 0.0071 0.0528 0.0809
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0095 0.0058
Brugia malayi beta-lactamase family protein 0.0026 0.0087 0.0082
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0027 0.0095 0.0058
Plasmodium falciparum serine repeat antigen 7 0.0071 0.0528 0.0809
Loa Loa (eye worm) cysteine protease 0.0307 0.2813 0.4577
Echinococcus multilocularis p2X purinoceptor 4 0.0417 0.3875 0.3852
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Echinococcus multilocularis cysteine protease 0.0307 0.2813 0.2786
Echinococcus granulosus lamin dm0 0.0022 0.0048 0.001
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0307 0.2813 0.4613
Brugia malayi Cytochrome P450 family protein 0.0021 0.004 0.0005
Echinococcus granulosus tm gpcr rhodopsin 0.0027 0.0095 0.0058
Echinococcus granulosus p2X purinoceptor 4 0.0417 0.3875 0.3852
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0307 0.2813 0.4579
Echinococcus granulosus cathepsin L cysteine proteinase 0.0307 0.2813 0.2786
Giardia lamblia Cysteine protease 0.0071 0.0528 0.1832
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0307 0.2813 0.4579
Giardia lamblia Hypothetical protein 0.0071 0.0528 0.1832
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Entamoeba histolytica hypothetical protein 0.0071 0.0528 0.0866
Echinococcus multilocularis g-protein coupled receptor 0.0027 0.0095 0.0058
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0034 0.0169 0.0217
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Schistosoma mansoni neuropeptide F-like receptor 0.0027 0.0095 0.0095
Echinococcus multilocularis fmrfamide receptor 0.0027 0.0095 0.0058
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Onchocerca volvulus Neuropeptide F receptor homolog 0.0027 0.0095 0.0172
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0167 0.1454 0.2385
Giardia lamblia Cathepsin B-like cysteine proteinase 3 precursor 0.0071 0.0528 0.1832
Plasmodium vivax serine-repeat antigen 4 (SERA) 0.0071 0.0528 0.0809
Echinococcus granulosus cathepsin L 0.0167 0.1454 0.1422
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0167 0.1454 0.2385
Onchocerca volvulus 0.0027 0.0095 0.0172
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0095 0.0095
Schistosoma mansoni subfamily C1A non-peptidase homologue (C01 family) 0.0071 0.0528 0.0809
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Echinococcus granulosus G protein coupled receptor 139 0.0027 0.0095 0.0058
Echinococcus granulosus cytochrome P450 2K1 0.0021 0.004 0.0003
Giardia lamblia Cathepsin B precursor 0.0071 0.0528 0.1832
Brugia malayi cathepsin L precursor 0.0071 0.0528 0.0809
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Echinococcus granulosus histone acetyltransferase KAT2B 0.0113 0.0931 0.0897
Trichomonas vaginalis D-aminoacylase, putative 0.0026 0.0087 0.0143
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0027 0.0095 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0528 0.0866
Brugia malayi cytochrome P450 0.0021 0.004 0.0005
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0027 0.0095 0.0095
Entamoeba histolytica cysteine protease, putative 0.0167 0.1454 0.2385
Entamoeba histolytica cysteine protease, putative 0.0167 0.1454 0.2385
Schistosoma mansoni P2X receptor subunit 0.0417 0.3875 0.6329
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Brugia malayi cathepsin Z-like cysteine proteinase 0.0071 0.0528 0.0809
Brugia malayi AKH receptor 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Trypanosoma cruzi cysteine peptidase, putative 0.0307 0.2813 0.4611
Brugia malayi Papain family cysteine protease containing protein 0.0071 0.0528 0.0809
Entamoeba histolytica cysteine protease, putative 0.0167 0.1454 0.2385
Echinococcus granulosus g protein coupled receptor 0.0027 0.0095 0.0058
Brugia malayi RNA, U transporter 1 0.0058 0.0404 0.0605
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0167 0.1454 0.2384
Mycobacterium leprae Probable lipase LipE 0.0026 0.0087 1
Entamoeba histolytica cysteine proteinase, putative 0.0307 0.2813 0.4613
Brugia malayi Cytochrome P450 family protein 0.0021 0.004 0.0005
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0071 0.0528 0.0809
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0027 0.0095 0.0095
Plasmodium falciparum cysteine proteinase falcipain 1 0.0167 0.1454 0.2338
Onchocerca volvulus 0.0307 0.2813 1
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0646 0.6098 1
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.004 0.0066
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0027 0.0095 0.0058
Brugia malayi Cathepsin L-like precursor 0.0212 0.1887 0.305
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0071 0.0528 0.0866
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0095 0.0058
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0027 0.0095 0.0095
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0167 0.1454 0.2337
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Plasmodium vivax serine-repeat antigen (SERA) 0.0071 0.0528 0.0809
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Onchocerca volvulus 0.0026 0.0087 0.0142
Loa Loa (eye worm) cyclic AMP specific phosphodiesterase PDE4D5A 0.0028 0.0108 0.0116
Brugia malayi Intermediate filament tail domain containing protein 0.0022 0.0048 0.0017
Loa Loa (eye worm) G-protein coupled receptor 0.0027 0.0095 0.0095
Trypanosoma brucei hypothetical protein, conserved 0.0026 0.0087 0.0082
Leishmania major cathepsin L-like protease 0.0307 0.2813 0.4613
Brugia malayi neuropeptide F receptor 0.0027 0.0095 0.0095
Echinococcus multilocularis beta LACTamase domain containing family member 0.0026 0.0087 0.005
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0095 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L, S or H-like cysteine peptidase 0.0071 0.0528 0.0866
Loa Loa (eye worm) hypothetical protein 0.0212 0.1887 0.305
Mycobacterium tuberculosis Probable esterase LipL 0.0026 0.0087 0.0337
Onchocerca volvulus 0.0027 0.0095 0.0172
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0027 0.0095 0.0058
Loa Loa (eye worm) hypothetical protein 0.0647 0.6101 1
Schistosoma mansoni opsin-like receptor 0.0027 0.0095 0.0095
Schistosoma mansoni camp-specific 35-cyclic phosphodiesterase 0.0032 0.0146 0.0178
Toxoplasma gondii cathepsin B 0.0249 0.2252 0.3653
Plasmodium falciparum serine repeat antigen 8 0.0071 0.0528 0.0809
Echinococcus granulosus neuropeptide Y receptor 0.0027 0.0095 0.0058
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Echinococcus granulosus neuropeptides capa receptor 0.0027 0.0095 0.0058
Onchocerca volvulus 0.0027 0.0095 0.0172
Brugia malayi Serotonin receptor 0.0027 0.0095 0.0095
Leishmania major cytochrome p450-like protein 0.0021 0.004 0.0066
Brugia malayi cathepsin F-like cysteine proteinase 0.0071 0.0528 0.0809
Plasmodium vivax serine-repeat antigen 5 (SERA) 0.0071 0.0528 0.0809
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Echinococcus multilocularis cAMP specific 3',5' cyclic phosphodiesterase 0.0032 0.0146 0.0108
Mycobacterium tuberculosis Probable lipase LipD 0.0026 0.0087 0.0337
Brugia malayi putative neuropeptide receptor 0.0027 0.0095 0.0095
Giardia lamblia Cathepsin L-like protease 0.0071 0.0528 0.1832
Brugia malayi cathepsin L-like precursor 0.0212 0.1887 0.305
Entamoeba histolytica cysteine protease, putative 0.0167 0.1454 0.2385
Entamoeba histolytica papain family cysteine protease domain containing protein 0.0071 0.0528 0.0866
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0034 0.0169 0.0217
Leishmania major lanosterol 14-alpha-demethylase, putative 0.0021 0.004 0.0066
Brugia malayi hypothetical protein 0.0027 0.0095 0.0095
Echinococcus granulosus hypothetical protein 0.0027 0.0095 0.0058
Loa Loa (eye worm) hypothetical protein 0.0071 0.0528 0.0809
Echinococcus multilocularis p2X purinoceptor 4 0.0417 0.3875 0.3852
Toxoplasma gondii 3'5'-cyclic nucleotide phosphodiesterase domain-containing protein 0.0032 0.0146 0.0178
Loa Loa (eye worm) ubiquitin conjugating enzyme protein 13 0.0646 0.6098 0.9995
Brugia malayi putative neuropeptide receptor NPR1 0.0027 0.0095 0.0095
Plasmodium falciparum serine repeat antigen 9 0.0071 0.0528 0.0809
Echinococcus multilocularis musashi 0.0022 0.0048 0.001
Onchocerca volvulus 0.0027 0.0095 0.0172
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0116 0.0962 0.1525
Loa Loa (eye worm) cathepsin B 0.0249 0.2252 0.3652
Schistosoma mansoni myosin xvIII 0.0027 0.0095 0.0095
Schistosoma mansoni opsin-like receptor 0.0027 0.0095 0.0095
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0027 0.0095 0.0058
Onchocerca volvulus 0.0307 0.2813 1
Brugia malayi acetyltransferase, GNAT family protein 0.0116 0.0962 0.1525
Schistosoma mansoni hypothetical protein 0.0027 0.0095 0.0095
Schistosoma mansoni ubiquitin conjugating enzyme 13 0.0646 0.6098 0.9995
Brugia malayi Cytochrome P450 family protein 0.0021 0.004 0.0005
Trypanosoma cruzi major cysteine proteinase, putative 0.0071 0.0528 0.0866
Plasmodium vivax dipeptidyl aminopeptidase 2, putative 0.0071 0.0528 0.0809
Giardia lamblia Cathepsin B precursor 0.0249 0.2252 1
Echinococcus multilocularis neuropeptides capa receptor 0.0027 0.0095 0.0058
Echinococcus granulosus tachykinin peptides receptor 99D 0.0027 0.0095 0.0058
Onchocerca volvulus 0.0027 0.0095 0.0172
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0307 0.2813 0.4613
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0307 0.2813 0.4613
Mycobacterium tuberculosis Conserved protein 0.0026 0.0087 0.0337
Brugia malayi Cytochrome P450 family protein 0.0021 0.004 0.0005
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0027 0.0095 0.0058
Loa Loa (eye worm) hypothetical protein 0.0212 0.1887 0.305
Plasmodium falciparum serine repeat antigen 1 0.0071 0.0528 0.0809
Giardia lamblia Dipeptidyl-peptidase I precursor 0.0071 0.0528 0.1832
Schistosoma mansoni cytochrome P450 0.0021 0.004 0.0005
Brugia malayi cathepsin F-like cysteine proteinase 0.0096 0.0765 0.12
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0307 0.2813 0.4613
Loa Loa (eye worm) hypothetical protein 0.0026 0.0087 0.0082
Onchocerca volvulus 0.0026 0.0087 0.0142
Entamoeba histolytica cysteine protease, putative 0.0071 0.0528 0.0866
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0095 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0212 0.1887 0.3094
Schistosoma mansoni amine GPCR 0.0027 0.0095 0.0095
Entamoeba histolytica cysteine protease, putative 0.0071 0.0528 0.0866
Onchocerca volvulus 0.0212 0.1887 0.665
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0307 0.2813 0.4613
Giardia lamblia Encystation-specific protease 0.0071 0.0528 0.1832
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0307 0.2813 0.4577
Onchocerca volvulus 0.0027 0.0095 0.0172
Echinococcus granulosus snurportin 1 0.0219 0.1962 0.1932
Schistosoma mansoni amine GPCR 0.0027 0.0095 0.0095
Onchocerca volvulus 0.0027 0.0095 0.0172
Mycobacterium ulcerans lipase LipD 0.0026 0.0087 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Giardia lamblia CAMP-specific 3,5-cyclic phosphodiesterase 4B 0.0032 0.0146 0.0019
Schistosoma mansoni lamin 0.0022 0.0048 0.0017
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0647 0.6101 1
Echinococcus granulosus neuropeptides capa receptor 0.0027 0.0095 0.0058
Plasmodium falciparum dipeptidyl aminopeptidase 3 0.0071 0.0528 0.0809
Echinococcus granulosus biogenic amine 5HT receptor 0.0027 0.0095 0.0058
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0307 0.2813 0.4579
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0095 0.0058
Giardia lamblia Cathepsin L precursor 0.0071 0.0528 0.1832
Loa Loa (eye worm) neuropeptide F receptor 0.0027 0.0095 0.0095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0095 0.0095
Entamoeba histolytica cysteine proteinase 2 0.0167 0.1454 0.2385
Trichomonas vaginalis conserved hypothetical protein 0.0071 0.0528 0.0866
Loa Loa (eye worm) hypothetical protein 0.0021 0.0044 0.001
Schistosoma mansoni amine GPCR 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Plasmodium vivax dipeptidyl aminopeptidase 3, putative 0.0071 0.0528 0.0809
Schistosoma mansoni adenoreceptor 0.0027 0.0095 0.0095
Schistosoma mansoni cathepsin F (C01 family) 0.0307 0.2813 0.4577
Trypanosoma cruzi cysteine peptidase, putative 0.0167 0.1454 0.2384
Brugia malayi Papain family cysteine protease containing protein 0.0167 0.1454 0.2337
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0095 0.0095
Leishmania major cytochrome p450-like protein 0.0021 0.004 0.0066
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0022 0.0048 0.0017
Trypanosoma brucei cysteine peptidase C (CPC) 0.0249 0.2252 0.3653
Trypanosoma cruzi cytochrome P450, putative 0.0021 0.004 0.0066
Echinococcus multilocularis neuropeptide receptor 0.0027 0.0095 0.0058
Schistosoma mansoni neuropeptide receptor 0.0027 0.0095 0.0095
Entamoeba histolytica cysteine protease, putative 0.0167 0.1454 0.2385
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.004 0.0005
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0307 0.2813 0.4613
Brugia malayi intermediate filament protein 0.0022 0.0048 0.0017
Echinococcus multilocularis G protein coupled receptor 139 0.0027 0.0095 0.0058
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0027 0.0095 0.0058
Loa Loa (eye worm) hypothetical protein 0.0022 0.0048 0.0017
Echinococcus multilocularis cathepsin L cysteine protease 0.0307 0.2813 0.2786
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0027 0.0095 0.0095
Leishmania major cytochrome p450-like protein 0.0021 0.004 0.0066
Echinococcus multilocularis fmrfamide receptor 0.0027 0.0095 0.0058
Trypanosoma cruzi cysteine proteinase, putative 0.0167 0.1454 0.2384
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0307 0.2813 0.4613
Plasmodium vivax vivapain-2 0.0307 0.2813 0.4579
Trypanosoma cruzi Lanosterol 14-alpha demethylase 0.0021 0.004 0.0066
Brugia malayi G-protein coupled receptor 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0071 0.0528 0.0809
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0026 0.0087 0.0337
Trypanosoma cruzi cysteine peptidase C (CPC), putative 0.0249 0.2252 0.3691
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0307 0.2813 0.4579
Echinococcus granulosus cathepsin L 0.0071 0.0528 0.0492
Schistosoma mansoni cathepsin F (C01 family) 0.0307 0.2813 0.4577
Plasmodium vivax serine-repeat antigen (SERA), putative 0.0071 0.0528 0.0809
Echinococcus granulosus p2X purinoceptor 4 0.0417 0.3875 0.3852
Giardia lamblia Cathepsin L precursor 0.0071 0.0528 0.1832
Toxoplasma gondii cathepsin CPC2 0.0071 0.0528 0.0809
Toxoplasma gondii cathepsin CPC1 0.0071 0.0528 0.0809
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0026 0.0087 0.0337
Schistosoma mansoni P2X receptor subunit 0.0417 0.3875 0.6329
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0647 0.6101 1
Loa Loa (eye worm) acetyltransferase 0.0116 0.0962 0.1525
Toxoplasma gondii cathepsin CPL 0.0307 0.2813 0.4579
Leishmania major cathepsin L-like protease 0.0307 0.2813 0.4613
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0095 0.0095
Echinococcus granulosus alpha 1A adrenergic receptor 0.0027 0.0095 0.0058
Echinococcus granulosus neuropeptide receptor A26 0.0027 0.0095 0.0058
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.0095 0.0095
Brugia malayi hypothetical protein 0.0027 0.0095 0.0095
Echinococcus granulosus 7TM GPCR rhodopsin 0.0027 0.0095 0.0058
Echinococcus granulosus cAMP specific 3'5' cyclic phosphodiesterase 0.0032 0.0146 0.0108
Echinococcus multilocularis cathepsin L 0.0071 0.0528 0.0492
Giardia lamblia Cysteine protease 0.0071 0.0528 0.1832
Brugia malayi GnHR receptor homolog 0.0027 0.0095 0.0095
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0027 0.0095 0.0095
Onchocerca volvulus 0.0307 0.2813 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0027 0.0095 0.0058
Brugia malayi neuropeptide F receptor 0.0027 0.0095 0.0095
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0116 0.0962 0.0928
Onchocerca volvulus Cathepsin L homolog 0.0307 0.2813 1
Loa Loa (eye worm) cytochrome P450 family protein 0.0021 0.004 0.0005
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0027 0.0095 0.0058
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0071 0.0528 0.0809
Onchocerca volvulus 0.0027 0.0095 0.0172
Echinococcus multilocularis serotonin receptor 0.0027 0.0095 0.0058
Brugia malayi Dopamine receptor protein 1 0.0027 0.0095 0.0095
Echinococcus granulosus cathepsin l1 0.0212 0.1887 0.1856
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0095 0.0058
Brugia malayi G protein-coupled receptor 0.0027 0.0095 0.0095
Schistosoma mansoni amine GPCR 0.0027 0.0095 0.0095
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0307 0.2813 0.4613
Echinococcus granulosus cathepsin b 0.0647 0.6101 0.6086
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0071 0.0528 0.0866
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0307 0.2813 0.4579
Schistosoma mansoni hypothetical protein 0.0027 0.0095 0.0095
Entamoeba histolytica cysteine protease, putative 0.0307 0.2813 0.4613
Giardia lamblia Cathepsin L precursor 0.0071 0.0528 0.1832
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0027 0.0095 0.0095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0167 0.1454 0.2338
Giardia lamblia Cathepsin B precursor 0.0071 0.0528 0.1832
Giardia lamblia Cathepsin B precursor 0.0249 0.2252 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0027 0.0095 0.0058
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0026 0.0087 0.0082
Entamoeba histolytica cysteine protease, putative 0.0071 0.0528 0.0866
Brugia malayi Papain family cysteine protease containing protein 0.0167 0.1454 0.2337
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Trypanosoma cruzi cysteine peptidase, putative 0.0307 0.2813 0.4611
Plasmodium vivax vivapain-2 0.0307 0.2813 0.4579
Echinococcus granulosus neuropeptide s receptor 0.0027 0.0095 0.0058
Echinococcus multilocularis cysteine protease 0.0307 0.2813 0.2786
Plasmodium vivax unspecified product 0.0096 0.0765 0.12
Brugia malayi Cathepsin L-like cysteine proteinase 0.0212 0.1887 0.305
Schistosoma mansoni growth hormone secretagogue receptor 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0096 0.0765 0.12
Brugia malayi hypothetical protein 0.0027 0.0095 0.0095
Echinococcus granulosus orexin receptor type 2 0.0027 0.0095 0.0058
Trichomonas vaginalis esterase, putative 0.0026 0.0087 0.0143
Brugia malayi Dopamine receptor 0.0027 0.0095 0.0095
Onchocerca volvulus 0.0027 0.0095 0.0172
Toxoplasma gondii ABC1 family protein 0.0026 0.0087 0.0082
Entamoeba histolytica cysteine protease, putative 0.0071 0.0528 0.0866
Loa Loa (eye worm) ctsf protein 0.0307 0.2813 0.4577
Schistosoma mansoni cathepsin B (C01 family) 0.0071 0.0528 0.0809
Echinococcus granulosus allatostatin A receptor 0.0027 0.0095 0.0058
Mycobacterium ulcerans beta-lactamase 0.0026 0.0087 1
Leishmania major cathepsin L-like protease 0.0307 0.2813 0.4613
Schistosoma mansoni amine GPCR 0.0027 0.0095 0.0095
Trichomonas vaginalis Clan CA, family C1, cathepsin B-like cysteine peptidase 0.0071 0.0528 0.0866
Schistosoma mansoni cathepsin B-like peptidase (C01 family) 0.0249 0.2252 0.3652
Loa Loa (eye worm) hypothetical protein 0.0032 0.0146 0.0178
Echinococcus multilocularis g protein coupled receptor 0.0027 0.0095 0.0058
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0027 0.0095 0.0095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0307 0.2813 0.4579
Brugia malayi cathepsin Z-like cysteine proteinase 0.0071 0.0528 0.0809
Loa Loa (eye worm) beta-lactamase 0.0026 0.0087 0.0082
Echinococcus multilocularis cathepsin L 0.0167 0.1454 0.1422
Trichomonas vaginalis Clan CA, family C1, cathepsin F-like cysteine peptidase 0.0071 0.0528 0.0866
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0026 0.0087 0.0337
Giardia lamblia Cysteine protease 0.0071 0.0528 0.1832
Echinococcus multilocularis somatostatin receptor 0.0027 0.0095 0.0058
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0307 0.2813 0.4613
Leishmania major cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like 0.0249 0.2252 0.3692
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0027 0.0095 0.0058
Trichomonas vaginalis ubiquitin-conjugating enzyme E2, putative 0.0646 0.6098 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Entamoeba histolytica cysteine protease, putative 0.0167 0.1454 0.2385
Trypanosoma cruzi cysteine proteinase, putative 0.0167 0.1454 0.2384
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0027 0.0095 0.0058
Brugia malayi Papain family cysteine protease containing protein 0.0071 0.0528 0.0809
Loa Loa (eye worm) hypothetical protein 0.0071 0.0528 0.0809
Onchocerca volvulus 0.0071 0.0528 0.1737
Echinococcus granulosus lamin 0.0022 0.0048 0.001
Brugia malayi Cathepsin L-like precursor 0.0096 0.0765 0.12
Schistosoma mansoni neuropeptide f receptor 76f 0.0027 0.0095 0.0095
Onchocerca volvulus 0.0307 0.2813 1
Echinococcus granulosus somatostatin receptor 0.0027 0.0095 0.0058
Entamoeba histolytica cysteine proteinase, putative 0.0167 0.1454 0.2385
Schistosoma mansoni neuropeptide receptor 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Plasmodium falciparum serine repeat antigen 2 0.0071 0.0528 0.0809
Echinococcus multilocularis G-protein coupled receptor, putative 0.0027 0.0095 0.0058
Echinococcus multilocularis serotonin receptor 0.0027 0.0095 0.0058
Echinococcus multilocularis neuropeptide Y receptor 0.0027 0.0095 0.0058
Brugia malayi Serotonin receptor 0.0027 0.0095 0.0095
Loa Loa (eye worm) cysteine proteinase cathepsin Z 0.0071 0.0528 0.0809
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0026 0.0087 0.0082
Plasmodium vivax unspecified product 0.0167 0.1454 0.2338
Plasmodium vivax vivapain-3 0.0167 0.1454 0.2338
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0095
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0027 0.0095 0.0095
Entamoeba histolytica ubiquitin-conjugating enzyme family protein 0.0646 0.6098 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0027 0.0095 0.0172
Brugia malayi follicle stimulating hormone receptor 0.0027 0.0095 0.0095
Brugia malayi sulfakinin receptor protein 0.0027 0.0095 0.0095
Loa Loa (eye worm) hypothetical protein 0.0026 0.0087 0.0082
Plasmodium vivax vivapain-1 0.0167 0.1454 0.2338
Loa Loa (eye worm) melatonin receptor type 1A 0.0027 0.0095 0.0095
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0027 0.0095 0.0058
Entamoeba histolytica cysteine proteinase, putative 0.0167 0.1454 0.2385
Leishmania major cysteine peptidase A (CPA) 0.0307 0.2813 0.4613
Echinococcus granulosus rhodopsin orphan GPCR 0.0027 0.0095 0.0058
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0027 0.0095 0.0095
Mycobacterium ulcerans esterase/lipase LipP 0.0026 0.0087 1
Brugia malayi RE15519p 0.0027 0.0095 0.0095
Trypanosoma brucei cytochrome P450, putative 0.0021 0.004 0.0005

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 9.5 mg kg-1 In vivo antifungal activity administered intraperitoneally against Candida albicans infections in mice. ChEMBL. 7650681
Inhibition (binding) = 71.4 % In vitro inhibition of glucan synthase obtained from C. albicans at a concentration of 10 ug/mL. ChEMBL. 7650681
MIC (functional) = 0.625 ug ml-1 Antifungal activity against Candida albicans ChEMBL. 7650681

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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